PMC:7464876 / 53833-54870
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7464876","sourcedb":"PMC","sourceid":"7464876","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7464876","text":"In regard to its ESCRT dependency and cell-imaging studies, HBV has been viewed as a MVB-budding virus [20,21,22,23,24,67]. However, the tracing of viral proteins or particles within the MVB/endosomal system does not mandatorily ascertain their use as viral exit portals. Rather, HBV progeny particles and proteins have been shown to be destructed within the endo-lysosomal system [68,69,70]. Many viruses have been shown to hijack and recruit the ESCRT machinery to wrap membranes around new virus particles at their particular budding sites [25]. Consistent with this, we found that Vps4A, the terminal ATPase of the ESCRT machinery, was specifically recruited by the HBV-specific ER-associated CS structure. In addition, the functional inactivation of the ESCRT-II complex inhibited the HBV release prior to N-glycan processing occurring within the Golgi complex. While the precise itinerary of HBV out of the cell remains to be decoded, our results altogether implicate that ESCRT-driven HBV assembly and budding may occur at the ER.","tracks":[{"project":"2_test","denotations":[{"id":"32806600-17553870-20296273","span":{"begin":104,"end":106},"obj":"17553870"},{"id":"32806600-17551004-20296274","span":{"begin":107,"end":109},"obj":"17551004"},{"id":"32806600-24614091-20296275","span":{"begin":110,"end":112},"obj":"24614091"},{"id":"32806600-26719264-20296276","span":{"begin":113,"end":115},"obj":"26719264"},{"id":"32806600-26431433-20296277","span":{"begin":116,"end":118},"obj":"26431433"},{"id":"32806600-26109732-20296278","span":{"begin":119,"end":121},"obj":"26109732"},{"id":"32806600-25770103-20296279","span":{"begin":382,"end":384},"obj":"25770103"},{"id":"32806600-22461906-20296280","span":{"begin":385,"end":387},"obj":"22461906"},{"id":"32806600-29876903-20296281","span":{"begin":388,"end":390},"obj":"29876903"}],"attributes":[{"subj":"32806600-17553870-20296273","pred":"source","obj":"2_test"},{"subj":"32806600-17551004-20296274","pred":"source","obj":"2_test"},{"subj":"32806600-24614091-20296275","pred":"source","obj":"2_test"},{"subj":"32806600-26719264-20296276","pred":"source","obj":"2_test"},{"subj":"32806600-26431433-20296277","pred":"source","obj":"2_test"},{"subj":"32806600-26109732-20296278","pred":"source","obj":"2_test"},{"subj":"32806600-25770103-20296279","pred":"source","obj":"2_test"},{"subj":"32806600-22461906-20296280","pred":"source","obj":"2_test"},{"subj":"32806600-29876903-20296281","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#c693ec","default":true}]}]}}