PMC:7464876 / 2324-3539
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7464876","sourcedb":"PMC","sourceid":"7464876","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7464876","text":"HBV is a hepatotropic, enveloped virus that replicates by protein-primed reverse transcription. Its genome merely encompasses four overlapping open reading frames (ORF) encoding the polymerase/reverse transcriptase (Pol), the capsid-forming core protein and its cognate secretory precore protein, as well as the regulatory X protein and three related envelope proteins [4,5,6]. The envelope proteins accomplish virion attachment to hepatocytes via binding to the liver cell-specific sodium taurocholate cotransporting polypeptide (NTCP) [7]. After HBV uptake and disassembly, the viral nucleocapsid (NC) is delivered to the nucleus where the partially double-stranded viral genome is complemented into a covalently closed circular DNA. This replication intermediate serves as a template for viral RNA transcription. The formation of progeny virions begins with the assembly of the icosahedral NC that selectively incorporates the viral pregenomic RNA (pgRNA) together with the viral polymerase, thereby warranting the synthesis of the progeny DNA genome through reverse transcription of the pgRNA. Mature NCs can then be enclosed by the viral envelope, composed of cellular lipids and viral glycoproteins [2,4,5,6].","tracks":[{"project":"2_test","denotations":[{"id":"32806600-26134841-20296155","span":{"begin":370,"end":371},"obj":"26134841"},{"id":"32806600-18339439-20296156","span":{"begin":372,"end":373},"obj":"18339439"},{"id":"32806600-27084037-20296157","span":{"begin":374,"end":375},"obj":"27084037"},{"id":"32806600-22965171-20296158","span":{"begin":1206,"end":1207},"obj":"22965171"},{"id":"32806600-26134841-20296159","span":{"begin":1208,"end":1209},"obj":"26134841"},{"id":"32806600-18339439-20296160","span":{"begin":1210,"end":1211},"obj":"18339439"},{"id":"32806600-27084037-20296161","span":{"begin":1212,"end":1213},"obj":"27084037"}],"attributes":[{"subj":"32806600-26134841-20296155","pred":"source","obj":"2_test"},{"subj":"32806600-18339439-20296156","pred":"source","obj":"2_test"},{"subj":"32806600-27084037-20296157","pred":"source","obj":"2_test"},{"subj":"32806600-22965171-20296158","pred":"source","obj":"2_test"},{"subj":"32806600-26134841-20296159","pred":"source","obj":"2_test"},{"subj":"32806600-18339439-20296160","pred":"source","obj":"2_test"},{"subj":"32806600-27084037-20296161","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ece1","default":true}]}]}}