PMC:7464116 / 82225-86130 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7464116","sourcedb":"PMC","sourceid":"7464116","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7464116","text":"Overview of Therapy\nCOVID-19 treatment is essentially supportive and, in fact, specific vaccines or therapies are not yet available. The COVID-19 vaccine is considered to be an effective prophylactic strategy. About 90 institutions around the world are working on identifying a specific and safe vaccine [148]. As of 8 April 2020, the global research and development landscape for COVID-19 vaccines has included 115 vaccine candidates. Most of these are currently in the preclinical phase and only some of these (mRNA-1273 from Moderna, Ad5-nCoV from CanSino Biologicals, INO-4800 from Inovio and LV-SMENP-DC and pathogen-specific aAPC from Shenzhen Geno-Immune Medical Institute) have recently moved into clinical development [149].\nThe therapeutic protocols used for the general population have also been adopted in patients with chronic renal failure, regardless of the stage of the disease [150].\nAntiviral drugs (Lopinavir/ritonavir (200/50 mg 2 cp × 2/day), Darunavir (800 mg/day), Ritonavir (100 mg/day), Darunavir/cobicistat (800/150 mg/day)) have been effective for the management of SARS-CoV-2 infection, in asymptomatic/paucisymptomatic patients and in patients with more severe manifestations [150,151].\nHydroxychloroquine (known as an antimalarial drug) was successfully used in the early stages of the pandemic until May 26th, 2020, when AIFA suspended authorization for its use for the treatment of SARS-CoV-2 infection [152,153].\nTocilizumab (anti-IL-6 monoclonal antibody) has been used in association with steroids and/or antiviral drugs, for the treatment of more severe clinical cases and patients with rapidly and significantly increasing levels of D-dimer. The dosage is 8 mg/kg body weight with a maximum infusion dose of 800 mg for a maximum of three administrations [154,155].\nUnlike hydroxychloroquine, both antiviral drugs and tocilizumab do not require dosage adjustments in relation to the values of the glomerular filtrate [150].\nGiven the state of hypercoagulability and the high incidence of thromboembolic complications in COVID-19 patients, high doses of low molecular weight heparin have been added to the therapeutic protocols [156].\nFor kidney transplant patients, immunosuppressive therapy must be reshaped, in particular, mycophenolate, azathioprine and calcineurin inhibitors must be suspended during the active phases of the disease [150]. Tocilizumab, on the other hand, may be effective in these patients, but randomized trials are needed [157].\nFor COVID-19 patients undergoing intermittent dialysis, the methods that obtain the greatest clearance of the pro-inflammatory molecules are preferred; in patients with AKI, hemodynamically unstable and requiring dialysis, continuous dialysis treatments are preferred (CVVH with pre and post-dilution at a dose \u003e 25 mL/Kg/h), using citrate as the first choice anticoagulant (after serial assessments of serum calcium and lactic acid) and, alternatively, unfractionated heparin (constantly monitoring the patient’s APPT) [150].\nInterferons have also been proposed as a possible therapy, although the timing of their use is critical since their benefit is realized if given before or early on in infection and may actually be harmful if given in the later stages. Clinical studies are underway to test their efficacy [158].\nA recent phosphoproteomics analysis of SARS-CoV-2 infected Vero E6 cells (a cell line derived from monkey kidney epithelial cells) showed dramatic changes in phosphorylation of both host and viral proteins. Furthermore, viral infection induced the formation of casein kinase II (CK2)-containing filopodia containing budding viral particles. The authors have stated that pharmacologic inhibition of several kinases including CK2 and p38 MAP (mitogen-activated protein) kinases may be potential future COVID-19 therapies [159].\nA summary of the main contents of this paper is depicted in Table 1.","divisions":[{"label":"title","span":{"begin":0,"end":19}},{"label":"p","span":{"begin":20,"end":733}},{"label":"p","span":{"begin":734,"end":900}},{"label":"p","span":{"begin":901,"end":1215}},{"label":"p","span":{"begin":1216,"end":1445}},{"label":"p","span":{"begin":1446,"end":1801}},{"label":"p","span":{"begin":1802,"end":1959}},{"label":"p","span":{"begin":1960,"end":2169}},{"label":"p","span":{"begin":2170,"end":2488}},{"label":"p","span":{"begin":2489,"end":3015}},{"label":"p","span":{"begin":3016,"end":3310}},{"label":"p","span":{"begin":3311,"end":3836}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T431","span":{"begin":513,"end":517},"obj":"Body_part"},{"id":"T432","span":{"begin":1464,"end":1466},"obj":"Body_part"},{"id":"T433","span":{"begin":1480,"end":1488},"obj":"Body_part"},{"id":"T434","span":{"begin":1701,"end":1705},"obj":"Body_part"},{"id":"T435","span":{"begin":2110,"end":2117},"obj":"Body_part"},{"id":"T436","span":{"begin":2174,"end":2180},"obj":"Body_part"},{"id":"T437","span":{"begin":2407,"end":2411},"obj":"Body_part"},{"id":"T438","span":{"begin":2892,"end":2897},"obj":"Body_part"},{"id":"T439","span":{"begin":2958,"end":2965},"obj":"Body_part"},{"id":"T440","span":{"begin":3378,"end":3383},"obj":"Body_part"},{"id":"T441","span":{"begin":3387,"end":3391},"obj":"Body_part"},{"id":"T442","span":{"begin":3417,"end":3423},"obj":"Body_part"},{"id":"T443","span":{"begin":3424,"end":3440},"obj":"Body_part"},{"id":"T444","span":{"begin":3435,"end":3440},"obj":"Body_part"},{"id":"T445","span":{"begin":3508,"end":3516},"obj":"Body_part"},{"id":"T446","span":{"begin":3747,"end":3750},"obj":"Body_part"},{"id":"T447","span":{"begin":3770,"end":3777},"obj":"Body_part"}],"attributes":[{"id":"A431","pred":"fma_id","subj":"T431","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A432","pred":"fma_id","subj":"T432","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A433","pred":"fma_id","subj":"T433","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A434","pred":"fma_id","subj":"T434","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A435","pred":"fma_id","subj":"T435","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A436","pred":"fma_id","subj":"T436","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A437","pred":"fma_id","subj":"T437","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A438","pred":"fma_id","subj":"T438","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A439","pred":"fma_id","subj":"T439","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A440","pred":"fma_id","subj":"T440","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A441","pred":"fma_id","subj":"T441","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A442","pred":"fma_id","subj":"T442","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A443","pred":"fma_id","subj":"T443","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A444","pred":"fma_id","subj":"T444","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A445","pred":"fma_id","subj":"T445","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A446","pred":"fma_id","subj":"T446","obj":"http://purl.org/sig/ont/fma/fma67847"},{"id":"A447","pred":"fma_id","subj":"T447","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T431","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T432","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T433","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T434","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T435","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T436","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T438","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T440","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T441","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T442","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T443","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T444","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T445","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T446","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T447","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T240","span":{"begin":2174,"end":2180},"obj":"Body_part"},{"id":"T241","span":{"begin":2407,"end":2411},"obj":"Body_part"},{"id":"T242","span":{"begin":2892,"end":2897},"obj":"Body_part"},{"id":"T243","span":{"begin":3417,"end":3423},"obj":"Body_part"}],"attributes":[{"id":"A240","pred":"uberon_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A241","pred":"uberon_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A242","pred":"uberon_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A243","pred":"uberon_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T771","span":{"begin":20,"end":28},"obj":"Disease"},{"id":"T772","span":{"begin":137,"end":145},"obj":"Disease"},{"id":"T773","span":{"begin":381,"end":389},"obj":"Disease"},{"id":"T774","span":{"begin":537,"end":540},"obj":"Disease"},{"id":"T775","span":{"begin":832,"end":853},"obj":"Disease"},{"id":"T776","span":{"begin":840,"end":853},"obj":"Disease"},{"id":"T777","span":{"begin":1093,"end":1101},"obj":"Disease"},{"id":"T778","span":{"begin":1093,"end":1097},"obj":"Disease"},{"id":"T779","span":{"begin":1104,"end":1113},"obj":"Disease"},{"id":"T780","span":{"begin":1414,"end":1422},"obj":"Disease"},{"id":"T781","span":{"begin":1414,"end":1418},"obj":"Disease"},{"id":"T782","span":{"begin":1425,"end":1434},"obj":"Disease"},{"id":"T783","span":{"begin":1979,"end":1997},"obj":"Disease"},{"id":"T784","span":{"begin":2056,"end":2064},"obj":"Disease"},{"id":"T785","span":{"begin":2493,"end":2501},"obj":"Disease"},{"id":"T786","span":{"begin":2658,"end":2661},"obj":"Disease"},{"id":"T787","span":{"begin":3183,"end":3192},"obj":"Disease"},{"id":"T788","span":{"begin":3350,"end":3358},"obj":"Disease"},{"id":"T789","span":{"begin":3350,"end":3354},"obj":"Disease"},{"id":"T790","span":{"begin":3531,"end":3546},"obj":"Disease"},{"id":"T791","span":{"begin":3537,"end":3546},"obj":"Disease"},{"id":"T792","span":{"begin":3811,"end":3819},"obj":"Disease"}],"attributes":[{"id":"A771","pred":"mondo_id","subj":"T771","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A772","pred":"mondo_id","subj":"T772","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A773","pred":"mondo_id","subj":"T773","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A774","pred":"mondo_id","subj":"T774","obj":"http://purl.obolibrary.org/obo/MONDO_0011194"},{"id":"A775","pred":"mondo_id","subj":"T775","obj":"http://purl.obolibrary.org/obo/MONDO_0024327"},{"id":"A776","pred":"mondo_id","subj":"T776","obj":"http://purl.obolibrary.org/obo/MONDO_0001106"},{"id":"A777","pred":"mondo_id","subj":"T777","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A778","pred":"mondo_id","subj":"T778","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A779","pred":"mondo_id","subj":"T779","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A780","pred":"mondo_id","subj":"T780","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A781","pred":"mondo_id","subj":"T781","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A782","pred":"mondo_id","subj":"T782","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A783","pred":"mondo_id","subj":"T783","obj":"http://purl.obolibrary.org/obo/MONDO_0002305"},{"id":"A784","pred":"mondo_id","subj":"T784","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A785","pred":"mondo_id","subj":"T785","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A786","pred":"mondo_id","subj":"T786","obj":"http://purl.obolibrary.org/obo/MONDO_0002492"},{"id":"A787","pred":"mondo_id","subj":"T787","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A788","pred":"mondo_id","subj":"T788","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A789","pred":"mondo_id","subj":"T789","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A790","pred":"mondo_id","subj":"T790","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A791","pred":"mondo_id","subj":"T791","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A792","pred":"mondo_id","subj":"T792","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T771","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T772","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T773","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T774","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T775","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T776","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T777","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T778","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T779","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T780","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T781","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T782","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T783","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T784","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T785","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T786","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T787","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T788","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T789","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T790","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T791","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T792","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T930","span":{"begin":276,"end":277},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T931","span":{"begin":305,"end":308},"obj":"http://purl.obolibrary.org/obo/CLO_0001079"},{"id":"T932","span":{"begin":399,"end":402},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T933","span":{"begin":951,"end":953},"obj":"http://purl.obolibrary.org/obo/PR_000005794"},{"id":"T934","span":{"begin":1490,"end":1493},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T935","span":{"begin":1718,"end":1719},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T936","span":{"begin":1756,"end":1757},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T937","span":{"begin":2174,"end":2180},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T938","span":{"begin":2174,"end":2180},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T939","span":{"begin":2174,"end":2180},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T940","span":{"begin":2345,"end":2351},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T941","span":{"begin":2793,"end":2794},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T942","span":{"begin":3055,"end":3056},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T943","span":{"begin":3284,"end":3288},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T944","span":{"begin":3311,"end":3312},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T945","span":{"begin":3370,"end":3383},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T946","span":{"begin":3385,"end":3386},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T947","span":{"begin":3387,"end":3396},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T948","span":{"begin":3410,"end":3416},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9479"},{"id":"T949","span":{"begin":3417,"end":3423},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T950","span":{"begin":3417,"end":3423},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T951","span":{"begin":3417,"end":3423},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T952","span":{"begin":3424,"end":3434},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T953","span":{"begin":3435,"end":3440},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T954","span":{"begin":3760,"end":3769},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T955","span":{"begin":3837,"end":3838},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T930","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T931","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T932","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T933","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T934","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T935","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T936","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T937","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T938","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T939","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T940","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T941","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T942","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T943","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T944","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T945","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T946","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T947","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T948","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T949","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T950","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T951","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T952","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T953","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T954","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T955","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T96197","span":{"begin":597,"end":599},"obj":"Chemical"},{"id":"T12865","span":{"begin":911,"end":916},"obj":"Chemical"},{"id":"T69633","span":{"begin":918,"end":927},"obj":"Chemical"},{"id":"T79","span":{"begin":928,"end":937},"obj":"Chemical"},{"id":"T30120","span":{"begin":964,"end":973},"obj":"Chemical"},{"id":"T31323","span":{"begin":1012,"end":1021},"obj":"Chemical"},{"id":"T25808","span":{"begin":1022,"end":1032},"obj":"Chemical"},{"id":"T5776","span":{"begin":1248,"end":1260},"obj":"Chemical"},{"id":"T84","span":{"begin":1261,"end":1265},"obj":"Chemical"},{"id":"T53955","span":{"begin":1464,"end":1466},"obj":"Chemical"},{"id":"T59409","span":{"begin":1524,"end":1532},"obj":"Chemical"},{"id":"T40321","span":{"begin":1540,"end":1555},"obj":"Chemical"},{"id":"T35540","span":{"begin":1540,"end":1549},"obj":"Chemical"},{"id":"T69824","span":{"begin":1550,"end":1555},"obj":"Chemical"},{"id":"T38518","span":{"begin":1809,"end":1827},"obj":"Chemical"},{"id":"T92","span":{"begin":1834,"end":1849},"obj":"Chemical"},{"id":"T31846","span":{"begin":1834,"end":1843},"obj":"Chemical"},{"id":"T29182","span":{"begin":1844,"end":1849},"obj":"Chemical"},{"id":"T95","span":{"begin":1854,"end":1865},"obj":"Chemical"},{"id":"T96","span":{"begin":2110,"end":2117},"obj":"Chemical"},{"id":"T62823","span":{"begin":2261,"end":2274},"obj":"Chemical"},{"id":"T98","span":{"begin":2276,"end":2288},"obj":"Chemical"},{"id":"T99","span":{"begin":2293,"end":2315},"obj":"Chemical"},{"id":"T78373","span":{"begin":2293,"end":2304},"obj":"Chemical"},{"id":"T86520","span":{"begin":2305,"end":2315},"obj":"Chemical"},{"id":"T74720","span":{"begin":2616,"end":2625},"obj":"Chemical"},{"id":"T47606","span":{"begin":2821,"end":2828},"obj":"Chemical"},{"id":"T82750","span":{"begin":2849,"end":2862},"obj":"Chemical"},{"id":"T84545","span":{"begin":2898,"end":2905},"obj":"Chemical"},{"id":"T78945","span":{"begin":2917,"end":2921},"obj":"Chemical"},{"id":"T10647","span":{"begin":2958,"end":2965},"obj":"Chemical"},{"id":"T52509","span":{"begin":3508,"end":3516},"obj":"Chemical"},{"id":"T96792","span":{"begin":3586,"end":3588},"obj":"Chemical"},{"id":"T44921","span":{"begin":3747,"end":3750},"obj":"Chemical"},{"id":"T91233","span":{"begin":3752,"end":3759},"obj":"Chemical"},{"id":"T44799","span":{"begin":3770,"end":3777},"obj":"Chemical"}],"attributes":[{"id":"A37717","pred":"chebi_id","subj":"T96197","obj":"http://purl.obolibrary.org/obo/CHEBI_73579"},{"id":"A77768","pred":"chebi_id","subj":"T12865","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A88464","pred":"chebi_id","subj":"T69633","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A37362","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A76239","pred":"chebi_id","subj":"T30120","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A52000","pred":"chebi_id","subj":"T31323","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A77121","pred":"chebi_id","subj":"T25808","obj":"http://purl.obolibrary.org/obo/CHEBI_72291"},{"id":"A19614","pred":"chebi_id","subj":"T5776","obj":"http://purl.obolibrary.org/obo/CHEBI_38068"},{"id":"A32129","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A81642","pred":"chebi_id","subj":"T53955","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A5405","pred":"chebi_id","subj":"T53955","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A74367","pred":"chebi_id","subj":"T59409","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A93428","pred":"chebi_id","subj":"T40321","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A46905","pred":"chebi_id","subj":"T35540","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A98612","pred":"chebi_id","subj":"T69824","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A18203","pred":"chebi_id","subj":"T38518","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A53259","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A38794","pred":"chebi_id","subj":"T31846","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A5030","pred":"chebi_id","subj":"T29182","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A51992","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"},{"id":"A73645","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A36414","pred":"chebi_id","subj":"T62823","obj":"http://purl.obolibrary.org/obo/CHEBI_62932"},{"id":"A25136","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_2948"},{"id":"A72434","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_37153"},{"id":"A1066","pred":"chebi_id","subj":"T78373","obj":"http://purl.obolibrary.org/obo/CHEBI_53439"},{"id":"A95801","pred":"chebi_id","subj":"T86520","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A39867","pred":"chebi_id","subj":"T74720","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A5023","pred":"chebi_id","subj":"T47606","obj":"http://purl.obolibrary.org/obo/CHEBI_133748"},{"id":"A78776","pred":"chebi_id","subj":"T47606","obj":"http://purl.obolibrary.org/obo/CHEBI_16947"},{"id":"A80400","pred":"chebi_id","subj":"T47606","obj":"http://purl.obolibrary.org/obo/CHEBI_50744"},{"id":"A51439","pred":"chebi_id","subj":"T82750","obj":"http://purl.obolibrary.org/obo/CHEBI_50249"},{"id":"A20776","pred":"chebi_id","subj":"T84545","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A82635","pred":"chebi_id","subj":"T84545","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A5944","pred":"chebi_id","subj":"T78945","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A1473","pred":"chebi_id","subj":"T10647","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A54152","pred":"chebi_id","subj":"T52509","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A43972","pred":"chebi_id","subj":"T96792","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A31716","pred":"chebi_id","subj":"T44921","obj":"http://purl.obolibrary.org/obo/CHEBI_6716"},{"id":"A596","pred":"chebi_id","subj":"T91233","obj":"http://purl.obolibrary.org/obo/CHEBI_52290"},{"id":"A33189","pred":"chebi_id","subj":"T44799","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T96197","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12865","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T69633","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T30120","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31323","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25808","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5776","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T53955","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T59409","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40321","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T35540","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T69824","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38518","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31846","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T29182","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T62823","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T78373","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T86520","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74720","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T47606","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T82750","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T84545","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T78945","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10647","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T52509","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T96792","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T44921","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T91233","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T44799","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T114","span":{"begin":1933,"end":1952},"obj":"http://purl.obolibrary.org/obo/GO_0003094"},{"id":"T115","span":{"begin":2293,"end":2304},"obj":"http://purl.obolibrary.org/obo/GO_0004723"},{"id":"T116","span":{"begin":2293,"end":2304},"obj":"http://purl.obolibrary.org/obo/GO_0004722"},{"id":"T117","span":{"begin":3469,"end":3484},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T118","span":{"begin":3531,"end":3546},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T119","span":{"begin":3559,"end":3568},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T120","span":{"begin":3627,"end":3634},"obj":"http://purl.obolibrary.org/obo/GO_0007114"}],"attributes":[{"subj":"T114","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T492","span":{"begin":0,"end":19},"obj":"Sentence"},{"id":"T493","span":{"begin":20,"end":132},"obj":"Sentence"},{"id":"T494","span":{"begin":133,"end":209},"obj":"Sentence"},{"id":"T495","span":{"begin":210,"end":310},"obj":"Sentence"},{"id":"T496","span":{"begin":311,"end":435},"obj":"Sentence"},{"id":"T497","span":{"begin":436,"end":733},"obj":"Sentence"},{"id":"T498","span":{"begin":734,"end":900},"obj":"Sentence"},{"id":"T499","span":{"begin":901,"end":1215},"obj":"Sentence"},{"id":"T500","span":{"begin":1216,"end":1445},"obj":"Sentence"},{"id":"T501","span":{"begin":1446,"end":1678},"obj":"Sentence"},{"id":"T502","span":{"begin":1679,"end":1801},"obj":"Sentence"},{"id":"T503","span":{"begin":1802,"end":1959},"obj":"Sentence"},{"id":"T504","span":{"begin":1960,"end":2169},"obj":"Sentence"},{"id":"T505","span":{"begin":2170,"end":2380},"obj":"Sentence"},{"id":"T506","span":{"begin":2381,"end":2488},"obj":"Sentence"},{"id":"T507","span":{"begin":2489,"end":3015},"obj":"Sentence"},{"id":"T508","span":{"begin":3016,"end":3250},"obj":"Sentence"},{"id":"T509","span":{"begin":3251,"end":3310},"obj":"Sentence"},{"id":"T510","span":{"begin":3311,"end":3517},"obj":"Sentence"},{"id":"T511","span":{"begin":3518,"end":3651},"obj":"Sentence"},{"id":"T512","span":{"begin":3652,"end":3836},"obj":"Sentence"},{"id":"T513","span":{"begin":3837,"end":3905},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T492","pred":"source","obj":"LitCovid-sentences"},{"subj":"T493","pred":"source","obj":"LitCovid-sentences"},{"subj":"T494","pred":"source","obj":"LitCovid-sentences"},{"subj":"T495","pred":"source","obj":"LitCovid-sentences"},{"subj":"T496","pred":"source","obj":"LitCovid-sentences"},{"subj":"T497","pred":"source","obj":"LitCovid-sentences"},{"subj":"T498","pred":"source","obj":"LitCovid-sentences"},{"subj":"T499","pred":"source","obj":"LitCovid-sentences"},{"subj":"T500","pred":"source","obj":"LitCovid-sentences"},{"subj":"T501","pred":"source","obj":"LitCovid-sentences"},{"subj":"T502","pred":"source","obj":"LitCovid-sentences"},{"subj":"T503","pred":"source","obj":"LitCovid-sentences"},{"subj":"T504","pred":"source","obj":"LitCovid-sentences"},{"subj":"T505","pred":"source","obj":"LitCovid-sentences"},{"subj":"T506","pred":"source","obj":"LitCovid-sentences"},{"subj":"T507","pred":"source","obj":"LitCovid-sentences"},{"subj":"T508","pred":"source","obj":"LitCovid-sentences"},{"subj":"T509","pred":"source","obj":"LitCovid-sentences"},{"subj":"T510","pred":"source","obj":"LitCovid-sentences"},{"subj":"T511","pred":"source","obj":"LitCovid-sentences"},{"subj":"T512","pred":"source","obj":"LitCovid-sentences"},{"subj":"T513","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T325","span":{"begin":832,"end":853},"obj":"Phenotype"},{"id":"T326","span":{"begin":1979,"end":1997},"obj":"Phenotype"},{"id":"T327","span":{"begin":2024,"end":2038},"obj":"Phenotype"},{"id":"T328","span":{"begin":2658,"end":2661},"obj":"Phenotype"}],"attributes":[{"id":"A325","pred":"hp_id","subj":"T325","obj":"http://purl.obolibrary.org/obo/HP_0003774"},{"id":"A326","pred":"hp_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/HP_0100724"},{"id":"A327","pred":"hp_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/HP_0001907"},{"id":"A328","pred":"hp_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/HP_0001919"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2451","span":{"begin":537,"end":540},"obj":"Gene"},{"id":"2452","span":{"begin":541,"end":545},"obj":"Species"},{"id":"2453","span":{"begin":20,"end":28},"obj":"Disease"},{"id":"2454","span":{"begin":137,"end":145},"obj":"Disease"},{"id":"2455","span":{"begin":381,"end":389},"obj":"Disease"},{"id":"2458","span":{"begin":818,"end":826},"obj":"Species"},{"id":"2459","span":{"begin":832,"end":853},"obj":"Disease"},{"id":"2467","span":{"begin":1148,"end":1156},"obj":"Species"},{"id":"2468","span":{"begin":1164,"end":1172},"obj":"Species"},{"id":"2469","span":{"begin":918,"end":937},"obj":"Chemical"},{"id":"2470","span":{"begin":964,"end":973},"obj":"Chemical"},{"id":"2471","span":{"begin":988,"end":997},"obj":"Chemical"},{"id":"2472","span":{"begin":1012,"end":1032},"obj":"Chemical"},{"id":"2473","span":{"begin":1093,"end":1113},"obj":"Disease"},{"id":"2477","span":{"begin":1216,"end":1234},"obj":"Chemical"},{"id":"2478","span":{"begin":1352,"end":1356},"obj":"Chemical"},{"id":"2479","span":{"begin":1414,"end":1434},"obj":"Disease"},{"id":"2484","span":{"begin":1464,"end":1468},"obj":"Gene"},{"id":"2485","span":{"begin":1609,"end":1617},"obj":"Species"},{"id":"2486","span":{"begin":1446,"end":1457},"obj":"Chemical"},{"id":"2487","span":{"begin":1524,"end":1532},"obj":"Chemical"},{"id":"2490","span":{"begin":1809,"end":1827},"obj":"Chemical"},{"id":"2491","span":{"begin":1854,"end":1865},"obj":"Chemical"},{"id":"2497","span":{"begin":2065,"end":2073},"obj":"Species"},{"id":"2498","span":{"begin":2089,"end":2117},"obj":"Chemical"},{"id":"2499","span":{"begin":1979,"end":1997},"obj":"Disease"},{"id":"2500","span":{"begin":2024,"end":2052},"obj":"Disease"},{"id":"2501","span":{"begin":2056,"end":2064},"obj":"Disease"},{"id":"2507","span":{"begin":2192,"end":2200},"obj":"Species"},{"id":"2508","span":{"begin":2439,"end":2447},"obj":"Species"},{"id":"2509","span":{"begin":2261,"end":2274},"obj":"Chemical"},{"id":"2510","span":{"begin":2276,"end":2288},"obj":"Chemical"},{"id":"2511","span":{"begin":2381,"end":2392},"obj":"Chemical"},{"id":"2520","span":{"begin":2502,"end":2510},"obj":"Species"},{"id":"2521","span":{"begin":2644,"end":2652},"obj":"Species"},{"id":"2522","span":{"begin":2993,"end":3000},"obj":"Species"},{"id":"2523","span":{"begin":2821,"end":2828},"obj":"Chemical"},{"id":"2524","span":{"begin":2898,"end":2905},"obj":"Chemical"},{"id":"2525","span":{"begin":2910,"end":2921},"obj":"Chemical"},{"id":"2526","span":{"begin":2958,"end":2965},"obj":"Chemical"},{"id":"2527","span":{"begin":2493,"end":2501},"obj":"Disease"},{"id":"2529","span":{"begin":3183,"end":3192},"obj":"Disease"},{"id":"2535","span":{"begin":3743,"end":3746},"obj":"Gene"},{"id":"2536","span":{"begin":3350,"end":3369},"obj":"Disease"},{"id":"2537","span":{"begin":3531,"end":3546},"obj":"Disease"},{"id":"2538","span":{"begin":3811,"end":3819},"obj":"Disease"},{"id":"2539","span":{"begin":3375,"end":3377},"obj":"CellLine"}],"attributes":[{"id":"A2451","pred":"tao:has_database_id","subj":"2451","obj":"Gene:8081"},{"id":"A2452","pred":"tao:has_database_id","subj":"2452","obj":"Tax:2697049"},{"id":"A2453","pred":"tao:has_database_id","subj":"2453","obj":"MESH:C000657245"},{"id":"A2454","pred":"tao:has_database_id","subj":"2454","obj":"MESH:C000657245"},{"id":"A2455","pred":"tao:has_database_id","subj":"2455","obj":"MESH:C000657245"},{"id":"A2458","pred":"tao:has_database_id","subj":"2458","obj":"Tax:9606"},{"id":"A2459","pred":"tao:has_database_id","subj":"2459","obj":"MESH:D007676"},{"id":"A2467","pred":"tao:has_database_id","subj":"2467","obj":"Tax:9606"},{"id":"A2468","pred":"tao:has_database_id","subj":"2468","obj":"Tax:9606"},{"id":"A2469","pred":"tao:has_database_id","subj":"2469","obj":"MESH:C558899"},{"id":"A2470","pred":"tao:has_database_id","subj":"2470","obj":"MESH:D000069454"},{"id":"A2471","pred":"tao:has_database_id","subj":"2471","obj":"MESH:D019438"},{"id":"A2473","pred":"tao:has_database_id","subj":"2473","obj":"MESH:C000657245"},{"id":"A2477","pred":"tao:has_database_id","subj":"2477","obj":"MESH:D006886"},{"id":"A2479","pred":"tao:has_database_id","subj":"2479","obj":"MESH:C000657245"},{"id":"A2484","pred":"tao:has_database_id","subj":"2484","obj":"Gene:3569"},{"id":"A2485","pred":"tao:has_database_id","subj":"2485","obj":"Tax:9606"},{"id":"A2486","pred":"tao:has_database_id","subj":"2486","obj":"MESH:C502936"},{"id":"A2487","pred":"tao:has_database_id","subj":"2487","obj":"MESH:D013256"},{"id":"A2490","pred":"tao:has_database_id","subj":"2490","obj":"MESH:D006886"},{"id":"A2491","pred":"tao:has_database_id","subj":"2491","obj":"MESH:C502936"},{"id":"A2497","pred":"tao:has_database_id","subj":"2497","obj":"Tax:9606"},{"id":"A2498","pred":"tao:has_database_id","subj":"2498","obj":"MESH:D006495"},{"id":"A2499","pred":"tao:has_database_id","subj":"2499","obj":"MESH:D019851"},{"id":"A2500","pred":"tao:has_database_id","subj":"2500","obj":"MESH:D013923"},{"id":"A2501","pred":"tao:has_database_id","subj":"2501","obj":"MESH:C000657245"},{"id":"A2507","pred":"tao:has_database_id","subj":"2507","obj":"Tax:9606"},{"id":"A2508","pred":"tao:has_database_id","subj":"2508","obj":"Tax:9606"},{"id":"A2509","pred":"tao:has_database_id","subj":"2509","obj":"MESH:D009173"},{"id":"A2510","pred":"tao:has_database_id","subj":"2510","obj":"MESH:D001379"},{"id":"A2511","pred":"tao:has_database_id","subj":"2511","obj":"MESH:C502936"},{"id":"A2520","pred":"tao:has_database_id","subj":"2520","obj":"Tax:9606"},{"id":"A2521","pred":"tao:has_database_id","subj":"2521","obj":"Tax:9606"},{"id":"A2522","pred":"tao:has_database_id","subj":"2522","obj":"Tax:9606"},{"id":"A2523","pred":"tao:has_database_id","subj":"2523","obj":"MESH:D019343"},{"id":"A2524","pred":"tao:has_database_id","subj":"2524","obj":"MESH:D002118"},{"id":"A2525","pred":"tao:has_database_id","subj":"2525","obj":"MESH:D019344"},{"id":"A2526","pred":"tao:has_database_id","subj":"2526","obj":"MESH:D006493"},{"id":"A2527","pred":"tao:has_database_id","subj":"2527","obj":"MESH:C000657245"},{"id":"A2529","pred":"tao:has_database_id","subj":"2529","obj":"MESH:D007239"},{"id":"A2535","pred":"tao:has_database_id","subj":"2535","obj":"Gene:1432"},{"id":"A2536","pred":"tao:has_database_id","subj":"2536","obj":"MESH:C000657245"},{"id":"A2537","pred":"tao:has_database_id","subj":"2537","obj":"MESH:D001102"},{"id":"A2538","pred":"tao:has_database_id","subj":"2538","obj":"MESH:C000657245"},{"id":"A2539","pred":"tao:has_database_id","subj":"2539","obj":"CVCL:4582"},{"subj":"2451","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2452","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2453","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2454","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2455","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2458","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2459","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2467","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2468","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2469","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2470","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2471","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2472","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2473","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2477","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2478","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2479","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2484","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2485","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2486","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2487","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2490","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2491","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2497","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2498","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2499","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2500","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2501","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2507","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2508","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2509","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2510","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2511","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2520","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2521","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2522","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2523","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2524","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2525","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2526","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2527","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2529","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2535","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2536","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2537","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2538","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2539","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32759645-32347054-58096284","span":{"begin":305,"end":308},"obj":"32347054"},{"id":"32759645-32273591-58096285","span":{"begin":728,"end":731},"obj":"32273591"},{"id":"32759645-32075365-58096286","span":{"begin":1436,"end":1439},"obj":"32075365"},{"id":"32759645-32324363-58096287","span":{"begin":1440,"end":1443},"obj":"32324363"},{"id":"32759645-32234467-58096288","span":{"begin":1792,"end":1795},"obj":"32234467"},{"id":"32759645-32376398-58096289","span":{"begin":1796,"end":1799},"obj":"32376398"},{"id":"32759645-32646977-58096290","span":{"begin":3305,"end":3308},"obj":"32646977"}],"attributes":[{"subj":"32759645-32347054-58096284","pred":"source","obj":"2_test"},{"subj":"32759645-32273591-58096285","pred":"source","obj":"2_test"},{"subj":"32759645-32075365-58096286","pred":"source","obj":"2_test"},{"subj":"32759645-32324363-58096287","pred":"source","obj":"2_test"},{"subj":"32759645-32234467-58096288","pred":"source","obj":"2_test"},{"subj":"32759645-32376398-58096289","pred":"source","obj":"2_test"},{"subj":"32759645-32646977-58096290","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecd7","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecbd93"},{"id":"LitCovid-PD-MONDO","color":"#a393ec"},{"id":"LitCovid-PD-CLO","color":"#9cec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93b6"},{"id":"LitCovid-PD-GO-BP","color":"#93d0ec"},{"id":"LitCovid-sentences","color":"#eaec93"},{"id":"LitCovid-PD-HP","color":"#d493ec"},{"id":"LitCovid-PubTator","color":"#93ecba"},{"id":"2_test","color":"#eca093"}]}]}}