PMC:7464116 / 35149-36023 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T234","span":{"begin":312,"end":324},"obj":"Body_part"},{"id":"T235","span":{"begin":387,"end":397},"obj":"Body_part"},{"id":"T236","span":{"begin":537,"end":542},"obj":"Body_part"},{"id":"T237","span":{"begin":544,"end":555},"obj":"Body_part"},{"id":"T238","span":{"begin":626,"end":646},"obj":"Body_part"},{"id":"T239","span":{"begin":670,"end":681},"obj":"Body_part"},{"id":"T240","span":{"begin":685,"end":693},"obj":"Body_part"},{"id":"T241","span":{"begin":740,"end":751},"obj":"Body_part"},{"id":"T242","span":{"begin":792,"end":803},"obj":"Body_part"}],"attributes":[{"id":"A234","pred":"fma_id","subj":"T234","obj":"http://purl.org/sig/ont/fma/fma70977"},{"id":"A235","pred":"fma_id","subj":"T235","obj":"http://purl.org/sig/ont/fma/fma9639"},{"id":"A236","pred":"fma_id","subj":"T236","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A237","pred":"fma_id","subj":"T237","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma274259"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma63194"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T101","span":{"begin":260,"end":275},"obj":"Body_part"},{"id":"T102","span":{"begin":387,"end":397},"obj":"Body_part"},{"id":"T103","span":{"begin":626,"end":646},"obj":"Body_part"},{"id":"T104","span":{"begin":637,"end":646},"obj":"Body_part"},{"id":"T105","span":{"begin":780,"end":803},"obj":"Body_part"}],"attributes":[{"id":"A101","pred":"uberon_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/UBERON_0004134"},{"id":"A102","pred":"uberon_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"A103","pred":"uberon_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/UBERON_0004212"},{"id":"A104","pred":"uberon_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/UBERON_0001982"},{"id":"A105","pred":"uberon_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/UBERON_0005272"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T385","span":{"begin":221,"end":234},"obj":"Disease"}],"attributes":[{"id":"A385","pred":"mondo_id","subj":"T385","obj":"http://purl.obolibrary.org/obo/MONDO_0001106"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T503","span":{"begin":260,"end":275},"obj":"http://purl.obolibrary.org/obo/UBERON_0004134"},{"id":"T504","span":{"begin":387,"end":397},"obj":"http://purl.obolibrary.org/obo/UBERON_0000483"},{"id":"T505","span":{"begin":537,"end":542},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T506","span":{"begin":544,"end":555},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T507","span":{"begin":670,"end":681},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T508","span":{"begin":740,"end":751},"obj":"http://purl.obolibrary.org/obo/CL_0000232"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T90","span":{"begin":0,"end":5},"obj":"Chemical"}],"attributes":[{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T80","span":{"begin":356,"end":364},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T81","span":{"begin":356,"end":364},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T82","span":{"begin":356,"end":364},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T83","span":{"begin":356,"end":364},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T84","span":{"begin":544,"end":566},"obj":"http://purl.obolibrary.org/obo/GO_0034117"},{"id":"T85","span":{"begin":740,"end":763},"obj":"http://purl.obolibrary.org/obo/GO_0034117"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T216","span":{"begin":0,"end":235},"obj":"Sentence"},{"id":"T217","span":{"begin":236,"end":543},"obj":"Sentence"},{"id":"T218","span":{"begin":544,"end":874},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T127","span":{"begin":89,"end":104},"obj":"Phenotype"},{"id":"T128","span":{"begin":206,"end":234},"obj":"Phenotype"}],"attributes":[{"id":"A127","pred":"hp_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/HP_0000092"},{"id":"A128","pred":"hp_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/HP_0012622"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1083","span":{"begin":35,"end":46},"obj":"Chemical"},{"id":"1084","span":{"begin":51,"end":56},"obj":"Chemical"},{"id":"1085","span":{"begin":89,"end":104},"obj":"Disease"},{"id":"1086","span":{"begin":109,"end":129},"obj":"Disease"},{"id":"1087","span":{"begin":172,"end":184},"obj":"Disease"},{"id":"1088","span":{"begin":221,"end":234},"obj":"Disease"},{"id":"1089","span":{"begin":329,"end":350},"obj":"Disease"},{"id":"1090","span":{"begin":356,"end":364},"obj":"Disease"},{"id":"1091","span":{"begin":595,"end":606},"obj":"Disease"},{"id":"1092","span":{"begin":722,"end":729},"obj":"Disease"},{"id":"1093","span":{"begin":838,"end":865},"obj":"Disease"}],"attributes":[{"id":"A1083","pred":"tao:has_database_id","subj":"1083","obj":"MESH:D006416"},{"id":"A1084","pred":"tao:has_database_id","subj":"1084","obj":"MESH:D004801"},{"id":"A1085","pred":"tao:has_database_id","subj":"1085","obj":"MESH:D000230"},{"id":"A1086","pred":"tao:has_database_id","subj":"1086","obj":"MESH:D017563"},{"id":"A1087","pred":"tao:has_database_id","subj":"1087","obj":"MESH:D007674"},{"id":"A1088","pred":"tao:has_database_id","subj":"1088","obj":"MESH:D051437"},{"id":"A1089","pred":"tao:has_database_id","subj":"1089","obj":"MESH:C536522"},{"id":"A1090","pred":"tao:has_database_id","subj":"1090","obj":"MESH:D009336"},{"id":"A1091","pred":"tao:has_database_id","subj":"1091","obj":"MESH:D000402"},{"id":"A1092","pred":"tao:has_database_id","subj":"1092","obj":"MESH:D013927"},{"id":"A1093","pred":"tao:has_database_id","subj":"1093","obj":"MESH:D007674"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}

{"project":"2_test","denotations":[{"id":"32759645-32327202-58096222","span":{"begin":870,"end":872},"obj":"32327202"}],"text":"Light microscopy examination using Hematoxylin and Eosin staining may show the extent of tubular atrophy and interstitial disease, these are strong histological markers of renal damage and may also predict progression of renal failure. Using light microscopy, proximal tubule injurywas observed with the loss of brush border and vacuolar degeneration with necrosis and detachment of the epithelium observed in the lumen of the tubules; dilatation of the tubular lumen was also noted together with cellular debris resulting from necrosed cells. Erythrocyte aggregates were also observed, causing obstruction of peritubular and glomerular capillary loops, with no obvious erythrocyte or platelet fragmentation or any fibrin thrombi, and less erythrocyte aggregation was observed in peritubular capillaries in those cases with predominantly glomerular loop obstruction [65,66]."}