PMC:7464116 / 30745-32151
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T201 | 44-55 | Body_part | denotes | erythrocyte | http://purl.org/sig/ont/fma/fma62845 |
| T202 | 76-85 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T203 | 159-181 | Body_part | denotes | glomerular capillaries | http://purl.org/sig/ont/fma/fma274259 |
| T204 | 204-215 | Body_part | denotes | Erythrocyte | http://purl.org/sig/ont/fma/fma62845 |
| T205 | 293-304 | Body_part | denotes | erythrocyte | http://purl.org/sig/ont/fma/fma62845 |
| T206 | 499-511 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T207 | 589-606 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T208 | 601-606 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T209 | 614-620 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T210 | 696-707 | Body_part | denotes | endothelium | http://purl.org/sig/ont/fma/fma63916 |
| T211 | 1240-1245 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T212 | 1265-1269 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T213 | 1346-1358 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T214 | 1383-1400 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T215 | 1395-1400 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T85 | 159-181 | Body_part | denotes | glomerular capillaries | http://purl.obolibrary.org/obo/UBERON_0004212 |
| T86 | 614-620 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T87 | 696-707 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
| T88 | 960-966 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T335 | 185-193 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T336 | 251-263 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T337 | 324-335 | Disease | denotes | hypotension | http://purl.obolibrary.org/obo/MONDO_0005468 |
| T338 | 370-382 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T339 | 739-747 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T340 | 739-743 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T341 | 907-915 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T342 | 907-911 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T343 | 918-927 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T344 | 1212-1220 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T345 | 1212-1216 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T443 | 44-55 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocyte |
| T444 | 204-215 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | Erythrocyte |
| T445 | 278-279 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T446 | 293-304 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocyte |
| T447 | 398-408 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T448 | 499-511 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T449 | 512-515 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T450 | 537-538 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T451 | 589-606 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T452 | 614-620 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T453 | 614-620 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T454 | 614-620 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T455 | 696-707 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| T456 | 960-966 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organs |
| T457 | 1168-1169 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T458 | 1183-1186 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T459 | 1196-1197 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T460 | 1240-1245 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T461 | 1265-1269 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T462 | 1330-1331 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T463 | 1383-1400 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T86 | 858-863 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T87 | 1346-1358 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T63 | 44-66 | http://purl.obolibrary.org/obo/GO_0034117 | denotes | erythrocyte aggregates |
| T64 | 204-227 | http://purl.obolibrary.org/obo/GO_0034117 | denotes | Erythrocyte aggregation |
| T65 | 251-263 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T66 | 370-382 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T67 | 387-408 | http://purl.obolibrary.org/obo/GO_0006956 | denotes | complement activation |
| T68 | 1223-1239 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | invasion of host |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T188 | 0-203 | Sentence | denotes | Su et al. [66] demonstrated the presence of erythrocyte aggregates, without platelets or fibrinoid fragments, which obstructs the lumen of the peritubular and glomerular capillaries in COVID-19 patients. |
| T189 | 204-448 | Sentence | denotes | Erythrocyte aggregation, presumably induced by inflammation (reflected by a high rate of erythrocyte sedimentation) and hypotension, can potentiate oxidative stress, inflammation and complement activation, aggravating microvascular damage [64]. |
| T190 | 449-575 | Sentence | denotes | Furthermore, occlusion of microvascular lumens by erythrocytes has been associated with a variety of endothelial lesions [66]. |
| T191 | 576-674 | Sentence | denotes | Normally, in endothelial cells of the kidney, only ACE is expressed without detectable ACE-2 [79]. |
| T192 | 675-750 | Sentence | denotes | Therefore, the renal endothelium cannot be infected directly by SARS-CoV-2. |
| T193 | 751-869 | Sentence | denotes | However, this cannot be totally excluded, since ACE-2expressioncan be changed in pathological states or by drugs [66]. |
| T194 | 870-1065 | Sentence | denotes | Varga et al. recently concluded that SARS-CoV-2 infection induces endothelitis in various organs, directly and indirectly, and that could explain the systemic impairment of microcirculation [80]. |
| T195 | 1066-1158 | Sentence | denotes | Further studies are necessary to better understand the genesis of renal endothelial lesions. |
| T196 | 1159-1406 | Sentence | denotes | Of note, a recent study has proposed a new route for SARS-CoV-2 invasion of host cells via an alternative cell receptor known as CD147 (and also called basigin), which is a transmembrane glycoprotein and is expressed on all endothelial cells [81]. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T108 | 324-335 | Phenotype | denotes | hypotension | http://purl.obolibrary.org/obo/HP_0002615 |
| T109 | 352-368 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 948 | 627-630 | Gene | denotes | ACE | Gene:1636 |
| 949 | 663-668 | Gene | denotes | ACE-2 | Gene:59272 |
| 950 | 799-804 | Gene | denotes | ACE-2 | Gene:59272 |
| 951 | 1288-1293 | Gene | denotes | CD147 | Gene:682 |
| 952 | 194-202 | Species | denotes | patients | Tax:9606 |
| 953 | 739-749 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 954 | 1212-1222 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 955 | 159-181 | Disease | denotes | glomerular capillaries | MESH:D007674 |
| 956 | 185-193 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 957 | 251-263 | Disease | denotes | inflammation | MESH:D007249 |
| 958 | 324-335 | Disease | denotes | hypotension | MESH:D007022 |
| 959 | 370-382 | Disease | denotes | inflammation | MESH:D007249 |
| 960 | 718-726 | Disease | denotes | infected | MESH:D007239 |
| 961 | 907-927 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 962 | 936-948 | Disease | denotes | endothelitis | |
| 963 | 1132-1157 | Disease | denotes | renal endothelial lesions | MESH:D007674 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32759645-32327202-58096209 | 11-13 | 32327202 | denotes | 66 |
| 32759645-32366514-58096210 | 444-446 | 32366514 | denotes | 64 |
| 32759645-32327202-58096211 | 571-573 | 32327202 | denotes | 66 |
| 32759645-25664248-58096212 | 670-672 | 25664248 | denotes | 79 |
| 32759645-32327202-58096213 | 865-867 | 32327202 | denotes | 66 |