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PMC:7464116 / 14984-17228 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T37 115-120 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T38 178-190 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T39 178-182 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T40 448-452 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T41 453-456 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T42 532-539 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T43 675-680 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T44 835-848 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T45 835-839 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T46 863-871 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T47 1006-1010 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T48 1031-1038 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T49 1124-1132 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T50 1166-1170 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T51 1909-1923 Body_part denotes terminal ileum http://purl.org/sig/ont/fma/fma14966
T52 1935-1947 Body_part denotes renal cortex http://purl.org/sig/ont/fma/fma15581
T53 2051-2056 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T54 2090-2103 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T55 2090-2095 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T26 1918-1923 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T27 1941-1947 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T28 1997-2021 Body_part denotes Renin-Angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T29 2023-2027 Body_part denotes RAAS http://purl.obolibrary.org/obo/UBERON_0018229
T30 2051-2056 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T31 2090-2103 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T32 2090-2095 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T33 2096-2103 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T196 27-35 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T197 27-31 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T198 44-52 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T199 44-48 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T200 758-766 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T201 758-762 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T202 1584-1592 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T203 1709-1724 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T204 1715-1724 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T183 115-120 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T184 142-143 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 178-182 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T186 448-452 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T187 490-491 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 602-604 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T189 675-686 http://purl.obolibrary.org/obo/CL_0000000 denotes cells types
T190 835-839 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T191 840-848 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T192 910-917 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T193 1006-1016 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T194 1025-1030 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T195 1089-1094 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T196 1115-1123 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T197 1166-1170 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T198 1198-1200 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T199 1201-1206 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T200 1285-1290 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T201 1501-1502 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 1545-1550 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T203 1593-1598 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T204 1757-1758 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 1773-1775 http://purl.obolibrary.org/obo/CLO_0007448 denotes M1
T206 1773-1775 http://purl.obolibrary.org/obo/CLO_0050175 denotes M1
T207 1838-1846 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T208 1918-1923 http://purl.obolibrary.org/obo/UBERON_0002116 denotes ileum
T209 1941-1947 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T210 1958-1959 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T211 2051-2056 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T212 2051-2056 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T213 2090-2103 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessels
T214 2090-2103 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessels
T215 2167-2168 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T7 59-70 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T8 205-218 Chemical denotes Angiotensin I http://purl.obolibrary.org/obo/CHEBI_2718
T9 205-216 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T10 232-243 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T11 252-266 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T12 264-266 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T13 272-274 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T14 281-292 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T15 371-385 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T16 383-385 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T17 399-410 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T18 863-871 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T19 1124-1132 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T20 1339-1347 Chemical denotes glutamyl http://purl.obolibrary.org/obo/CHEBI_32483
T21 1399-1402 Chemical denotes DPP http://purl.obolibrary.org/obo/CHEBI_34680|http://purl.obolibrary.org/obo/CHEBI_60069
T23 1773-1775 Chemical denotes M1 http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826
T27 1826-1828 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T28 1847-1851 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T30 2003-2014 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T7 1166-1181 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T8 1709-1724 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T9 2037-2065 http://purl.obolibrary.org/obo/GO_0008217 denotes regulation of blood pressure
T10 2037-2047 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11 2077-2086 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T96 0-132 Sentence denotes Many studies reported that SARS-CoV-2, like SARS-CoV, uses Angiotensin converting enzyme 2 (ACE-2) to enter target cells [43,44,45].
T97 133-440 Sentence denotes ACE-2 is a carboxypeptidase expressed on the cell surface which cleaves Angiotensin I (Ang I) into Angiotensin 1–9 and Angiotensin II (Ang II) into Angiotensin 1–7, counteracting the vasoconstrictor, proliferative and fibrotic effects of Angiotensin II generated by Angiotensin converting enzyme (ACE) [46].
T98 441-606 Sentence denotes Single-cell RNA sequencing analysis demonstrated a wide distribution of ACE-2 in different tissues [12,47] and histochemical staining then confirmed these data [48].
T99 607-872 Sentence denotes However, since low levels of ACE-2 expression were found on several cells types [47], it was supposed that cellular interaction and internalization by SARS-CoV-2did not depend only on ACE-2, but depended also on other auxiliary cell membrane receptors and proteins.
T100 873-955 Sentence denotes In fact, it is recognized that ssRNA viruses tend to have multiple receptors [49].
T101 956-1133 Sentence denotes Qi et al. analyzed the expression of ACE-2 on 119 cell types from 13 human tissues and the coexpression characteristics of the ssRNA human viral receptors and membrane proteins.
T102 1134-1260 Sentence denotes Pearson correlation analysis of gene expression matrices showed 94 genes were found to be significantly correlated with ACE-2.
T103 1261-1453 Sentence denotes Among these, the coding genes of the peptidases alanylaminopeptidase (ANPEP), glutamyl aminopeptidase (ENPEP) and dipeptidyl peptidase 4 (DPP 4) showed the highest correlation with ACE-2 [12].
T104 1454-1747 Sentence denotes While both ANPEP and DPP4 are already known as a target receptors for other coronaviruses (human coronavirus 229E, swine epidemic diarrhea virus, canine coronavirus, feline coronavirus, for ANPEP and MERS-CoV for DPP4), the relationship between ENPEP and viral infection is not yet known [12].
T105 1748-1878 Sentence denotes ENPEP is a member of the M1 family of endopeptidases which are mammalian type II integral membrane zinc-containing endopeptidases.
T106 1879-2109 Sentence denotes It is mainly expressed in the terminal ileum and in the renal cortex and plays a role in the catabolic pathway of the Renin-Angiotensin system (RAAS), in the regulation of blood pressure and in the formation of blood vessels [50].
T107 2110-2244 Sentence denotes While the observations of Qi et al. suggest ENPEP may be a coronavirus receptor, further investigation is needed to confirm this [12].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T74 1584-1592 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
540 59-90 Gene denotes Angiotensin converting enzyme 2 Gene:59272
541 92-97 Gene denotes ACE-2 Gene:59272
542 133-138 Gene denotes ACE-2 Gene:59272
543 371-385 Gene denotes Angiotensin II Gene:183
544 399-428 Gene denotes Angiotensin converting enzyme Gene:1636
545 430-433 Gene denotes ACE Gene:1636
546 513-518 Gene denotes ACE-2 Gene:59272
547 636-641 Gene denotes ACE-2 Gene:59272
548 791-796 Gene denotes ACE-2 Gene:59272
549 993-998 Gene denotes ACE-2 Gene:59272
550 1254-1259 Gene denotes ACE-2 Gene:59272
551 1339-1362 Gene denotes glutamyl aminopeptidase Gene:2028
552 1364-1369 Gene denotes ENPEP Gene:2028
553 1375-1397 Gene denotes dipeptidyl peptidase 4 Gene:1803
554 1399-1404 Gene denotes DPP 4 Gene:1803
555 1442-1447 Gene denotes ACE-2 Gene:59272
556 1475-1479 Gene denotes DPP4 Gene:1803
557 1667-1671 Gene denotes DPP4 Gene:1803
558 1699-1704 Gene denotes ENPEP Gene:2028
559 1748-1753 Gene denotes ENPEP Gene:2028
560 2154-2159 Gene denotes ENPEP Gene:2028
561 27-37 Species denotes SARS-CoV-2 Tax:2697049
562 44-52 Species denotes SARS-CoV Tax:694009
563 758-768 Species denotes SARS-CoV-2 Tax:2697049
564 904-917 Species denotes ssRNA viruses Tax:439488
565 1025-1030 Species denotes human Tax:9606
566 1089-1094 Species denotes human Tax:9606
567 1530-1543 Species denotes coronaviruses Tax:11118
568 1545-1567 Species denotes human coronavirus 229E Tax:11137
569 1569-1574 Species denotes swine Tax:9823
570 1600-1618 Species denotes canine coronavirus Tax:11153
571 1620-1638 Species denotes feline coronavirus Tax:12663
572 1654-1662 Species denotes MERS-CoV Tax:1335626
573 1811-1820 Species denotes mammalian Tax:9606
574 2169-2180 Species denotes coronavirus Tax:11118
575 232-247 Chemical denotes Angiotensin 1–9
576 1584-1592 Disease denotes diarrhea MESH:D003967
577 1709-1724 Disease denotes viral infection MESH:D001102

2_test

Id Subject Object Predicate Lexical cue
32759645-32142651-58096167 122-124 32142651 denotes 43
32759645-32132184-58096168 125-127 32132184 denotes 44
32759645-32100877-58096169 128-130 32100877 denotes 45
32759645-17021266-58096170 436-438 17021266 denotes 46
32759645-30102334-58096171 951-953 30102334 denotes 49