PMC:7464116 / 14984-17228
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T37 | 115-120 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T38 | 178-190 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
T39 | 178-182 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T40 | 448-452 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T41 | 453-456 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T42 | 532-539 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T43 | 675-680 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T44 | 835-848 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
T45 | 835-839 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T46 | 863-871 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T47 | 1006-1010 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T48 | 1031-1038 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T49 | 1124-1132 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T50 | 1166-1170 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
T51 | 1909-1923 | Body_part | denotes | terminal ileum | http://purl.org/sig/ont/fma/fma14966 |
T52 | 1935-1947 | Body_part | denotes | renal cortex | http://purl.org/sig/ont/fma/fma15581 |
T53 | 2051-2056 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T54 | 2090-2103 | Body_part | denotes | blood vessels | http://purl.org/sig/ont/fma/fma63183 |
T55 | 2090-2095 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T26 | 1918-1923 | Body_part | denotes | ileum | http://purl.obolibrary.org/obo/UBERON_0002116 |
T27 | 1941-1947 | Body_part | denotes | cortex | http://purl.obolibrary.org/obo/UBERON_0001851 |
T28 | 1997-2021 | Body_part | denotes | Renin-Angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
T29 | 2023-2027 | Body_part | denotes | RAAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
T30 | 2051-2056 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T31 | 2090-2103 | Body_part | denotes | blood vessels | http://purl.obolibrary.org/obo/UBERON_0001981 |
T32 | 2090-2095 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T33 | 2096-2103 | Body_part | denotes | vessels | http://purl.obolibrary.org/obo/UBERON_0000055 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T196 | 27-35 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T197 | 27-31 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T198 | 44-52 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T199 | 44-48 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T200 | 758-766 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T201 | 758-762 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T202 | 1584-1592 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
T203 | 1709-1724 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
T204 | 1715-1724 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T183 | 115-120 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T184 | 142-143 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T185 | 178-182 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T186 | 448-452 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T187 | 490-491 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T188 | 602-604 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
T189 | 675-686 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells types |
T190 | 835-839 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T191 | 840-848 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T192 | 910-917 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T193 | 1006-1016 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell types |
T194 | 1025-1030 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T195 | 1089-1094 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T196 | 1115-1123 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T197 | 1166-1170 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T198 | 1198-1200 | http://purl.obolibrary.org/obo/CLO_0001527 | denotes | 94 |
T199 | 1201-1206 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
T200 | 1285-1290 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
T201 | 1501-1502 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T202 | 1545-1550 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T203 | 1593-1598 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T204 | 1757-1758 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T205 | 1773-1775 | http://purl.obolibrary.org/obo/CLO_0007448 | denotes | M1 |
T206 | 1773-1775 | http://purl.obolibrary.org/obo/CLO_0050175 | denotes | M1 |
T207 | 1838-1846 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T208 | 1918-1923 | http://purl.obolibrary.org/obo/UBERON_0002116 | denotes | ileum |
T209 | 1941-1947 | http://purl.obolibrary.org/obo/UBERON_0001851 | denotes | cortex |
T210 | 1958-1959 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T211 | 2051-2056 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T212 | 2051-2056 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T213 | 2090-2103 | http://purl.obolibrary.org/obo/UBERON_0001981 | denotes | blood vessels |
T214 | 2090-2103 | http://www.ebi.ac.uk/efo/EFO_0000817 | denotes | blood vessels |
T215 | 2167-2168 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T7 | 59-70 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
T8 | 205-218 | Chemical | denotes | Angiotensin I | http://purl.obolibrary.org/obo/CHEBI_2718 |
T9 | 205-216 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
T10 | 232-243 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
T11 | 252-266 | Chemical | denotes | Angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719 |
T12 | 264-266 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T13 | 272-274 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T14 | 281-292 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
T15 | 371-385 | Chemical | denotes | Angiotensin II | http://purl.obolibrary.org/obo/CHEBI_2719 |
T16 | 383-385 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T17 | 399-410 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
T18 | 863-871 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T19 | 1124-1132 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T20 | 1339-1347 | Chemical | denotes | glutamyl | http://purl.obolibrary.org/obo/CHEBI_32483 |
T21 | 1399-1402 | Chemical | denotes | DPP | http://purl.obolibrary.org/obo/CHEBI_34680|http://purl.obolibrary.org/obo/CHEBI_60069 |
T23 | 1773-1775 | Chemical | denotes | M1 | http://purl.obolibrary.org/obo/CHEBI_51079|http://purl.obolibrary.org/obo/CHEBI_139019|http://purl.obolibrary.org/obo/CHEBI_140152|http://purl.obolibrary.org/obo/CHEBI_34826 |
T27 | 1826-1828 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T28 | 1847-1851 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
T30 | 2003-2014 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T7 | 1166-1181 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T8 | 1709-1724 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
T9 | 2037-2065 | http://purl.obolibrary.org/obo/GO_0008217 | denotes | regulation of blood pressure |
T10 | 2037-2047 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T11 | 2077-2086 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T96 | 0-132 | Sentence | denotes | Many studies reported that SARS-CoV-2, like SARS-CoV, uses Angiotensin converting enzyme 2 (ACE-2) to enter target cells [43,44,45]. |
T97 | 133-440 | Sentence | denotes | ACE-2 is a carboxypeptidase expressed on the cell surface which cleaves Angiotensin I (Ang I) into Angiotensin 1–9 and Angiotensin II (Ang II) into Angiotensin 1–7, counteracting the vasoconstrictor, proliferative and fibrotic effects of Angiotensin II generated by Angiotensin converting enzyme (ACE) [46]. |
T98 | 441-606 | Sentence | denotes | Single-cell RNA sequencing analysis demonstrated a wide distribution of ACE-2 in different tissues [12,47] and histochemical staining then confirmed these data [48]. |
T99 | 607-872 | Sentence | denotes | However, since low levels of ACE-2 expression were found on several cells types [47], it was supposed that cellular interaction and internalization by SARS-CoV-2did not depend only on ACE-2, but depended also on other auxiliary cell membrane receptors and proteins. |
T100 | 873-955 | Sentence | denotes | In fact, it is recognized that ssRNA viruses tend to have multiple receptors [49]. |
T101 | 956-1133 | Sentence | denotes | Qi et al. analyzed the expression of ACE-2 on 119 cell types from 13 human tissues and the coexpression characteristics of the ssRNA human viral receptors and membrane proteins. |
T102 | 1134-1260 | Sentence | denotes | Pearson correlation analysis of gene expression matrices showed 94 genes were found to be significantly correlated with ACE-2. |
T103 | 1261-1453 | Sentence | denotes | Among these, the coding genes of the peptidases alanylaminopeptidase (ANPEP), glutamyl aminopeptidase (ENPEP) and dipeptidyl peptidase 4 (DPP 4) showed the highest correlation with ACE-2 [12]. |
T104 | 1454-1747 | Sentence | denotes | While both ANPEP and DPP4 are already known as a target receptors for other coronaviruses (human coronavirus 229E, swine epidemic diarrhea virus, canine coronavirus, feline coronavirus, for ANPEP and MERS-CoV for DPP4), the relationship between ENPEP and viral infection is not yet known [12]. |
T105 | 1748-1878 | Sentence | denotes | ENPEP is a member of the M1 family of endopeptidases which are mammalian type II integral membrane zinc-containing endopeptidases. |
T106 | 1879-2109 | Sentence | denotes | It is mainly expressed in the terminal ileum and in the renal cortex and plays a role in the catabolic pathway of the Renin-Angiotensin system (RAAS), in the regulation of blood pressure and in the formation of blood vessels [50]. |
T107 | 2110-2244 | Sentence | denotes | While the observations of Qi et al. suggest ENPEP may be a coronavirus receptor, further investigation is needed to confirm this [12]. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T74 | 1584-1592 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
540 | 59-90 | Gene | denotes | Angiotensin converting enzyme 2 | Gene:59272 |
541 | 92-97 | Gene | denotes | ACE-2 | Gene:59272 |
542 | 133-138 | Gene | denotes | ACE-2 | Gene:59272 |
543 | 371-385 | Gene | denotes | Angiotensin II | Gene:183 |
544 | 399-428 | Gene | denotes | Angiotensin converting enzyme | Gene:1636 |
545 | 430-433 | Gene | denotes | ACE | Gene:1636 |
546 | 513-518 | Gene | denotes | ACE-2 | Gene:59272 |
547 | 636-641 | Gene | denotes | ACE-2 | Gene:59272 |
548 | 791-796 | Gene | denotes | ACE-2 | Gene:59272 |
549 | 993-998 | Gene | denotes | ACE-2 | Gene:59272 |
550 | 1254-1259 | Gene | denotes | ACE-2 | Gene:59272 |
551 | 1339-1362 | Gene | denotes | glutamyl aminopeptidase | Gene:2028 |
552 | 1364-1369 | Gene | denotes | ENPEP | Gene:2028 |
553 | 1375-1397 | Gene | denotes | dipeptidyl peptidase 4 | Gene:1803 |
554 | 1399-1404 | Gene | denotes | DPP 4 | Gene:1803 |
555 | 1442-1447 | Gene | denotes | ACE-2 | Gene:59272 |
556 | 1475-1479 | Gene | denotes | DPP4 | Gene:1803 |
557 | 1667-1671 | Gene | denotes | DPP4 | Gene:1803 |
558 | 1699-1704 | Gene | denotes | ENPEP | Gene:2028 |
559 | 1748-1753 | Gene | denotes | ENPEP | Gene:2028 |
560 | 2154-2159 | Gene | denotes | ENPEP | Gene:2028 |
561 | 27-37 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
562 | 44-52 | Species | denotes | SARS-CoV | Tax:694009 |
563 | 758-768 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
564 | 904-917 | Species | denotes | ssRNA viruses | Tax:439488 |
565 | 1025-1030 | Species | denotes | human | Tax:9606 |
566 | 1089-1094 | Species | denotes | human | Tax:9606 |
567 | 1530-1543 | Species | denotes | coronaviruses | Tax:11118 |
568 | 1545-1567 | Species | denotes | human coronavirus 229E | Tax:11137 |
569 | 1569-1574 | Species | denotes | swine | Tax:9823 |
570 | 1600-1618 | Species | denotes | canine coronavirus | Tax:11153 |
571 | 1620-1638 | Species | denotes | feline coronavirus | Tax:12663 |
572 | 1654-1662 | Species | denotes | MERS-CoV | Tax:1335626 |
573 | 1811-1820 | Species | denotes | mammalian | Tax:9606 |
574 | 2169-2180 | Species | denotes | coronavirus | Tax:11118 |
575 | 232-247 | Chemical | denotes | Angiotensin 1–9 | |
576 | 1584-1592 | Disease | denotes | diarrhea | MESH:D003967 |
577 | 1709-1724 | Disease | denotes | viral infection | MESH:D001102 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32759645-32142651-58096167 | 122-124 | 32142651 | denotes | 43 |
32759645-32132184-58096168 | 125-127 | 32132184 | denotes | 44 |
32759645-32100877-58096169 | 128-130 | 32100877 | denotes | 45 |
32759645-17021266-58096170 | 436-438 | 17021266 | denotes | 46 |
32759645-30102334-58096171 | 951-953 | 30102334 | denotes | 49 |