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PMC:7463108 / 98612-100232 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 133-149 Body_part denotes neurotransmitter http://purl.org/sig/ont/fma/fma302832
T2 165-169 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T3 431-448 Body_part denotes neurotransmitters http://purl.org/sig/ont/fma/fma302832
T4 510-518 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T5 520-529 Body_part denotes serotonin http://purl.org/sig/ont/fma/fma67245
T6 559-572 Body_part denotes acetylcholine http://purl.org/sig/ont/fma/fma61789
T7 699-704 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T8 769-783 Body_part denotes frontal cortex http://purl.org/sig/ont/fma/fma61824
T9 789-797 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T10 825-833 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T11 838-852 Body_part denotes norepinephrine http://purl.org/sig/ont/fma/fma61799
T12 1058-1066 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T13 1203-1206 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T14 1234-1242 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T15 1336-1344 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T16 1359-1367 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T17 1385-1393 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T18 1473-1481 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T180 200-203 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T181 204-209 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T182 699-704 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T183 764-767 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T184 769-783 Body_part denotes frontal cortex http://purl.obolibrary.org/obo/UBERON_0001870
T185 777-783 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T186 789-797 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T187 1007-1010 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T188 1385-1393 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T209 1506-1518 Disease denotes opioid abuse http://purl.obolibrary.org/obo/MONDO_0001225

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 165-169 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T2 453-459 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T3 510-518 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T4 520-529 http://purl.obolibrary.org/obo/CHEBI_28790 denotes serotonin
T5 699-704 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6 699-704 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T7 777-783 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T8 825-833 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T9 991-999 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T10 1027-1028 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1058-1066 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T12 1234-1242 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T13 1336-1344 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T14 1359-1367 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T15 1473-1481 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T21762 133-149 Chemical denotes neurotransmitter http://purl.obolibrary.org/obo/CHEBI_25512
T99163 284-290 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T98849 431-448 Chemical denotes neurotransmitters http://purl.obolibrary.org/obo/CHEBI_25512
T88345 475-483 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T94074 510-518 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T30597 520-529 Chemical denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546
T23157 546-550 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T53196 552-556 Chemical denotes GABA http://purl.obolibrary.org/obo/CHEBI_16865
T93729 559-572 Chemical denotes acetylcholine http://purl.obolibrary.org/obo/CHEBI_15355
T22491 574-583 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T393 589-598 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T66783 618-626 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T81259 825-833 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T41515 838-852 Chemical denotes norepinephrine http://purl.obolibrary.org/obo/CHEBI_18357|http://purl.obolibrary.org/obo/CHEBI_33569
T87195 940-946 Chemical denotes Heroin http://purl.obolibrary.org/obo/CHEBI_27808
T2127 1058-1066 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T24088 1234-1242 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T62096 1336-1344 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T44600 1359-1367 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T93735 1473-1481 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T22751 1534-1538 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3431 1203-1206 Species denotes HIV Tax:12721
3432 1262-1266 Gene denotes Nath Gene:80155
3433 284-290 Chemical denotes heroin MESH:D003932
3434 475-483 Chemical denotes morphine MESH:D009020
3435 510-518 Chemical denotes dopamine MESH:D004298
3436 520-529 Chemical denotes serotonin MESH:D012701
3437 531-550 Chemical denotes γ-aminobutyric acid MESH:D005680
3438 552-556 Chemical denotes GABA MESH:D005680
3439 559-572 Chemical denotes acetylcholine MESH:D000109
3440 574-583 Chemical denotes aspartate MESH:D001224
3441 589-598 Chemical denotes glutamate MESH:D018698
3442 618-626 Chemical denotes morphine MESH:D009020
3443 825-833 Chemical denotes dopamine MESH:D004298
3444 838-852 Chemical denotes norepinephrine MESH:D009638
3445 940-946 Chemical denotes Heroin MESH:D003932
3446 1058-1066 Chemical denotes dopamine MESH:D004298
3447 1234-1242 Chemical denotes dopamine MESH:D004298
3448 1336-1344 Chemical denotes dopamine MESH:D004298
3449 1359-1367 Chemical denotes dopamine MESH:D004298
3450 1473-1481 Chemical denotes dopamine MESH:D004298
3451 1506-1529 Disease denotes opioid abuse tendencies MESH:D009293

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 133-160 http://purl.obolibrary.org/obo/GO_0042133 denotes neurotransmitter metabolism
T2 150-160 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T3 165-180 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T4 1058-1079 http://purl.obolibrary.org/obo/GO_0042416 denotes dopamine biosynthesis
T5 1067-1079 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T6 1243-1260 http://purl.obolibrary.org/obo/GO_0007268 denotes neurotransmission
T7 1359-1377 http://purl.obolibrary.org/obo/GO_0015872 denotes dopamine transport
T8 1368-1377 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T9 1547-1556 http://purl.obolibrary.org/obo/GO_0007610 denotes behaviors

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1250 0-181 Sentence denotes Additionally, the nature of opiate exposure in the context of neuroHIV needs to be considered as it may induce different outcomes on neurotransmitter metabolism and gene expression.
T1251 182-325 Sentence denotes Specifically, the NAc shell demonstrates molecular and structural changes associated with intravenous heroin self-administration (Jacobs et al.
T1252 326-332 Sentence denotes 2005).
T1253 333-640 Sentence denotes Moreover, earlier studies have reported differential alterations in the turnover rates of various neurotransmitters for active versus passive morphine administration, including dopamine, serotonin, γ-aminobutyric acid (GABA), acetylcholine, aspartate, and glutamate during exposure to morphine (Smith et al.
T1254 641-653 Sentence denotes 1982, 1984).
T1255 654-932 Sentence denotes The disruptions were noticed specifically in brain regions involved in reinforcement processes, including the NAc, frontal cortex, and striatum, and encompassed increased dopamine and norepinephrine levels and turnover, which are central in opiate reward processes (Smith et al.
T1256 933-939 Sentence denotes 1982).
T1257 940-1181 Sentence denotes Heroin abuse is known to downregulate dopaminergic activity in the NAc and may reflect a compensatory reduction in of dopamine biosynthesis in response to excessive dopaminergic stimulation resulting from chronic opiate exposure (Kish et al.
T1258 1182-1188 Sentence denotes 2001).
T1259 1189-1273 Sentence denotes Additionally, HIV is known to interfere with dopamine neurotransmission (Nath et al.
T1260 1274-1295 Sentence denotes 2000b; Gaskill et al.
T1261 1296-1406 Sentence denotes 2017) causing reductions in presynaptic dopamine terminals and dopamine transport in the striatum (Wang et al.
T1262 1407-1425 Sentence denotes 2004; Chang et al.
T1263 1426-1444 Sentence denotes 2008; Midde et al.
T1264 1445-1457 Sentence denotes 2012, 2015).
T1265 1458-1620 Sentence denotes The decline in dopamine function may exacerbate opioid abuse tendencies and drug-seeking behaviors as the rewarding effects of opioids are discounted by neuroHIV.

2_test

Id Subject Object Predicate Lexical cue
32876803-15849023-62958336 326-330 15849023 denotes 2005
32876803-6123120-62958337 641-645 6123120 denotes 1982
32876803-6538688-62958338 647-651 6538688 denotes 1984
32876803-6123120-62958339 933-937 6123120 denotes 1982
32876803-11282256-62958340 1182-1186 11282256 denotes 2001
32876803-15319273-62958342 1407-1411 15319273 denotes 2004
32876803-18579413-62958343 1426-1430 18579413 denotes 2008