PMC:7463108 / 96985-98611
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T917 | 69-72 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
| T918 | 485-494 | Body_part | denotes | pituitary | http://purl.org/sig/ont/fma/fma13889 |
| T919 | 509-513 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T920 | 553-561 | Body_part | denotes | dopamine | http://purl.org/sig/ont/fma/fma67238 |
| T921 | 672-676 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T922 | 678-708 | Body_part | denotes | corticotropin releasing factor | http://purl.org/sig/ont/fma/fma83354 |
| T923 | 1416-1420 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T924 | 1461-1464 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T925 | 1504-1508 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T926 | 1517-1520 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
| T927 | 1534-1542 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T178 | 69-72 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T179 | 1517-1520 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T205 | 485-494 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
| T206 | 1245-1263 | Disease | denotes | immune suppression | http://purl.obolibrary.org/obo/MONDO_0007816 |
| T207 | 1461-1474 | Disease | denotes | HIV infection | http://purl.obolibrary.org/obo/MONDO_0005109 |
| T208 | 1465-1474 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T972 | 69-72 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T973 | 69-72 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T974 | 69-72 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
| T975 | 128-129 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T976 | 553-561 | http://purl.obolibrary.org/obo/CHEBI_18243 | denotes | dopamine |
| T977 | 654-663 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T978 | 744-745 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T979 | 1015-1025 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T980 | 1188-1198 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T981 | 1517-1520 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T982 | 1517-1520 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T983 | 1517-1520 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T389 | 151-155 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T93960 | 186-190 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T19189 | 397-401 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T97969 | 504-507 | Chemical | denotes | HPA | http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342 |
| T44514 | 553-561 | Chemical | denotes | dopamine | http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905 |
| T14707 | 668-671 | Chemical | denotes | HPA | http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342 |
| T29525 | 678-708 | Chemical | denotes | corticotropin releasing factor | http://purl.obolibrary.org/obo/CHEBI_65311 |
| T403 | 678-691 | Chemical | denotes | corticotropin | http://purl.obolibrary.org/obo/CHEBI_3892 |
| T13587 | 903-911 | Chemical | denotes | cortisol | http://purl.obolibrary.org/obo/CHEBI_17650 |
| T405 | 1011-1014 | Chemical | denotes | HPA | http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342 |
| T18273 | 1184-1187 | Chemical | denotes | HPA | http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342 |
| T40484 | 1337-1341 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T60355 | 1342-1351 | Chemical | denotes | methadone | http://purl.obolibrary.org/obo/CHEBI_6807 |
| T52802 | 1412-1415 | Chemical | denotes | HPA | http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342 |
| T84484 | 1500-1503 | Chemical | denotes | HPA | http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 3397 | 678-708 | Gene | denotes | corticotropin releasing factor | Gene:1392 |
| 3398 | 553-561 | Chemical | denotes | dopamine | MESH:D004298 |
| 3399 | 903-911 | Chemical | denotes | cortisol | MESH:D006854 |
| 3400 | 1342-1351 | Chemical | denotes | methadone | MESH:D008691 |
| 3401 | 472-502 | Disease | denotes | hypothalamic-pituitary-adrenal | MESH:D007029 |
| 3402 | 504-507 | Disease | denotes | HPA | MESH:D010661 |
| 3403 | 668-671 | Disease | denotes | HPA | MESH:D010661 |
| 3404 | 1011-1014 | Disease | denotes | HPA | MESH:D010661 |
| 3405 | 1184-1187 | Disease | denotes | HPA | MESH:D010661 |
| 3406 | 1412-1415 | Disease | denotes | HPA | MESH:D010661 |
| 3407 | 1461-1474 | Disease | denotes | HIV infection | MESH:D015658 |
| 3408 | 1500-1503 | Disease | denotes | HPA | MESH:D010661 |
| 3409 | 1521-1529 | Disease | denotes | toxicity | MESH:D064420 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T182 | 725-740 | http://purl.obolibrary.org/obo/GO_0006694 | denotes | steroidogenesis |
| T183 | 1534-1553 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | cytokine production |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1236 | 0-222 | Sentence | denotes | Opiate self-administration as seen with addiction can have different CNS consequences than “steady-state” (e.g., continuous via a pump or time-release drug implant) exposure to the same drug (Kreek 1987, 2001; Kreek et al. |
| T1237 | 223-338 | Sentence | denotes | 2002), and we predict the pharmacokinetic differences in opiate exposure will markedly impact neuroHIV progression. |
| T1238 | 339-594 | Sentence | denotes | Differential effects based on “on-off” and “steady-state” drug administration schedules have been reported for the stress-responsive hypothalamic-pituitary-adrenal (HPA) axis, the endogenous opioid system, and the dopamine system (Kreek 1973; Kreek et al. |
| T1239 | 595-614 | Sentence | denotes | 2002; George et al. |
| T1240 | 615-621 | Sentence | denotes | 2012). |
| T1241 | 622-816 | Sentence | denotes | Acute opiate exposure typically activates the HPA axis, corticotropin releasing factor, and peripheral steroidogenesis in a species-dependent manner (Koob and Kreek 2007; Cleck and Blendy 2008). |
| T1242 | 817-943 | Sentence | denotes | Alternatively, chronic self-administration of short-acting opiates suppresses diurnal cortisol rhythmicity (Facchinetti et al. |
| T1243 | 944-962 | Sentence | denotes | 1984; Vuong et al. |
| T1244 | 963-1084 | Sentence | denotes | 2010), while opiate withdrawal typically evokes HPA activation (Culpepper-Morgan and Kreek 1997; Kreek 2007; Paris et al. |
| T1245 | 1085-1091 | Sentence | denotes | 2020). |
| T1246 | 1092-1282 | Sentence | denotes | The daily, repeated bouts of relative withdrawal seen with opiate addiction cause sustained HPA activation, stress (Koob and Kreek 2007; Koob 2020), and immune suppression (Eisenstein 2019). |
| T1247 | 1283-1434 | Sentence | denotes | Importantly, maintenance therapy with the long-acting drug methadone achieves steady-dose opiate levels and normalization of the HPA axis (Kreek 1973). |
| T1248 | 1435-1567 | Sentence | denotes | Further, it is known that HIV infection significantly alters the HPA axis, due to CNS toxicity and cytokine production (Costa et al. |
| T1249 | 1568-1626 | Sentence | denotes | 2000; George and Bhangoo 2013; Chrousos and Zapanti 2014). |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32876803-3125471-62958318 | 198-202 | 3125471 | denotes | 1987 |
| 32876803-11458539-62958319 | 204-208 | 11458539 | denotes | 2001 |
| 32876803-12209151-62958320 | 223-227 | 12209151 | denotes | 2002 |
| 32876803-4739193-62958321 | 576-580 | 4739193 | denotes | 1973 |
| 32876803-12209151-62958322 | 595-599 | 12209151 | denotes | 2002 |
| 32876803-22108506-62958323 | 615-619 | 22108506 | denotes | 2012 |
| 32876803-17671276-62958324 | 787-791 | 17671276 | denotes | 2007 |
| 32876803-18246196-62958325 | 810-814 | 18246196 | denotes | 2008 |
| 32876803-6320568-62958326 | 944-948 | 6320568 | denotes | 1984 |
| 32876803-19903933-62958327 | 963-967 | 19903933 | denotes | 2010 |
| 32876803-9030816-62958328 | 1054-1058 | 9030816 | denotes | 1997 |
| 32876803-18286797-62958329 | 1066-1070 | 18286797 | denotes | 2007 |
| 32876803-17671276-62958330 | 1223-1227 | 17671276 | denotes | 2007 |
| 32876803-31400808-62958331 | 1234-1238 | 31400808 | denotes | 2020 |
| 32876803-31921165-62958332 | 1276-1280 | 31921165 | denotes | 2019 |
| 32876803-4739193-62958333 | 1428-1432 | 4739193 | denotes | 1973 |
| 32876803-11085902-62958334 | 1568-1572 | 11085902 | denotes | 2000 |
| 32876803-23728720-62958335 | 1593-1597 | 23728720 | denotes | 2013 |