PMC:7463108 / 9623-10203 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12225","span":{"begin":114,"end":126},"obj":"Body_part"},{"id":"T62361","span":{"begin":142,"end":145},"obj":"Body_part"},{"id":"T70209","span":{"begin":431,"end":434},"obj":"Body_part"},{"id":"T54610","span":{"begin":451,"end":463},"obj":"Body_part"},{"id":"T92740","span":{"begin":520,"end":526},"obj":"Body_part"},{"id":"T88403","span":{"begin":567,"end":570},"obj":"Body_part"}],"attributes":[{"id":"A66583","pred":"fma_id","subj":"T12225","obj":"http://purl.org/sig/ont/fma/fma83929"},{"id":"A24894","pred":"fma_id","subj":"T62361","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A88653","pred":"fma_id","subj":"T70209","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A19954","pred":"fma_id","subj":"T54610","obj":"http://purl.org/sig/ont/fma/fma83929"},{"id":"A31994","pred":"fma_id","subj":"T92740","obj":"http://purl.org/sig/ont/fma/fma62977"},{"id":"A78119","pred":"fma_id","subj":"T88403","obj":"http://purl.org/sig/ont/fma/fma55675"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T20","span":{"begin":114,"end":126},"obj":"Body_part"},{"id":"T21","span":{"begin":142,"end":145},"obj":"Body_part"},{"id":"T22","span":{"begin":451,"end":463},"obj":"Body_part"},{"id":"T23","span":{"begin":520,"end":526},"obj":"Body_part"},{"id":"T24","span":{"begin":567,"end":570},"obj":"Body_part"}],"attributes":[{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0002316"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0002316"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0000345"},{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T17","span":{"begin":233,"end":245},"obj":"Disease"}],"attributes":[{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T8189","span":{"begin":50,"end":52},"obj":"http://purl.obolibrary.org/obo/CLO_0050160"},{"id":"T95684","span":{"begin":142,"end":145},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T53516","span":{"begin":142,"end":145},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T23483","span":{"begin":142,"end":145},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T99017","span":{"begin":341,"end":343},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T26720","span":{"begin":341,"end":343},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T98729","span":{"begin":386,"end":387},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8555","span":{"begin":567,"end":570},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T18804","span":{"begin":567,"end":570},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T44390","span":{"begin":567,"end":570},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T38","span":{"begin":10,"end":16},"obj":"Chemical"},{"id":"T39","span":{"begin":50,"end":52},"obj":"Chemical"},{"id":"T41","span":{"begin":341,"end":343},"obj":"Chemical"}],"attributes":[{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_27808"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_29298"},{"id":"A40","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_75710"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}

{"project":"LitCovid-PubTator","denotations":[{"id":"161","span":{"begin":431,"end":434},"obj":"Species"},{"id":"162","span":{"begin":10,"end":16},"obj":"Chemical"},{"id":"163","span":{"begin":233,"end":245},"obj":"Disease"}],"attributes":[{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"Tax:12721"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"MESH:D003932"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T19813","span":{"begin":233,"end":245},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}

{"project":"LitCovid-sentences","denotations":[{"id":"T98","span":{"begin":0,"end":280},"obj":"Sentence"},{"id":"T99","span":{"begin":281,"end":298},"obj":"Sentence"},{"id":"T100","span":{"begin":299,"end":315},"obj":"Sentence"},{"id":"T101","span":{"begin":316,"end":334},"obj":"Sentence"},{"id":"T102","span":{"begin":335,"end":350},"obj":"Sentence"},{"id":"T103","span":{"begin":351,"end":369},"obj":"Sentence"},{"id":"T104","span":{"begin":370,"end":376},"obj":"Sentence"},{"id":"T105","span":{"begin":377,"end":580},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}

{"project":"2_test","denotations":[{"id":"32876803-20558415-62957879","span":{"begin":281,"end":285},"obj":"20558415"},{"id":"32876803-21070508-62957880","span":{"begin":299,"end":303},"obj":"21070508"},{"id":"32876803-23650554-62957881","span":{"begin":316,"end":320},"obj":"23650554"},{"id":"32876803-25035700-62957882","span":{"begin":335,"end":339},"obj":"25035700"},{"id":"32876803-26794650-62957883","span":{"begin":351,"end":355},"obj":"26794650"},{"id":"32876803-28424016-62957884","span":{"begin":370,"end":374},"obj":"28424016"}],"text":"Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes."}