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PMC:7463108 / 93932-95637 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T879 154-158 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T880 412-415 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T881 469-473 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T882 533-544 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T883 549-553 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T884 670-680 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T885 692-703 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T886 733-744 Body_part denotes enkephalins http://purl.org/sig/ont/fma/fma83367
T887 801-810 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T888 890-902 Body_part denotes Granulocytes http://purl.org/sig/ont/fma/fma62854
T889 1021-1032 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T890 1100-1134 Body_part denotes peripheral blood mononuclear cells http://purl.org/sig/ont/fma/fma86713
T891 1129-1134 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T892 1283-1292 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T893 1302-1315 Body_part denotes interleukin-1 http://purl.org/sig/ont/fma/fma86583
T894 1318-1322 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T895 1431-1441 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T896 1466-1471 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T897 1577-1586 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T898 1626-1630 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T899 1660-1663 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T900 1669-1672 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T171 1111-1116 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T172 1466-1471 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T200 412-425 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T201 416-425 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T202 849-866 Disease denotes neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T203 1199-1211 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T204 1227-1245 Disease denotes multiple sclerosis http://purl.obolibrary.org/obo/MONDO_0005301

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T946 315-316 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T947 523-532 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T948 837-845 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T949 955-956 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T950 1100-1134 http://purl.obolibrary.org/obo/CL_0000842 denotes peripheral blood mononuclear cells
T951 1100-1134 http://purl.obolibrary.org/obo/CL_2000001 denotes peripheral blood mononuclear cells
T952 1302-1315 http://purl.obolibrary.org/obo/PR_000001091 denotes interleukin-1
T953 1431-1441 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T954 1466-1471 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T955 1466-1471 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T956 1577-1586 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T71926 837-845 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T56974 1008-1014 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T15446 1318-1320 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T383 1517-1519 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3325 148-153 Gene denotes OPRK1 Gene:18387
3326 481-486 Gene denotes OPRK1 Gene:4986
3327 717-728 Gene denotes β-endorphin Gene:5443
3328 942-953 Gene denotes β-endorphin Gene:5443
3329 970-973 Gene denotes MOR Gene:4988
3330 993-996 Gene denotes KOR Gene:4986
3331 1074-1085 Gene denotes β-endorphin Gene:5443
3332 1302-1316 Gene denotes interleukin-1β Gene:3553
3333 1318-1323 Gene denotes IL-1β Gene:3552
3334 1394-1407 Gene denotes proenkephalin Gene:5179
3338 224-234 Species denotes transgenic Tax:10090
3341 412-425 Disease denotes HIV infection MESH:D015658
3342 1199-1211 Disease denotes inflammation MESH:D007249
3343 1227-1245 Disease denotes multiple sclerosis MESH:D009103

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T181 1199-1211 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1201 0-105 Sentence denotes Postmortem clinical studies indicate the endogenous opioid system is disrupted in neuroHIV (Gelman et al.
T1202 106-126 Sentence denotes 2012; Yuferov et al.
T1203 127-133 Sentence denotes 2014).
T1204 134-210 Sentence denotes Specifically, OPRK1 mRNA is significantly upregulated in PWH (Yuferov et al.
T1205 211-271 Sentence denotes 2014) and in transgenic neuroHIV rodent models (Chang et al.
T1206 272-292 Sentence denotes 2007; Fitting et al.
T1207 293-441 Sentence denotes 2010b) potentially as a compensatory neuroprotective function in response to inflammatory processes in the presence of HIV infection (Yuferov et al.
T1208 442-448 Sentence denotes 2014).
T1209 449-632 Sentence denotes The upregulation of mRNA coding OPRK1 is triggered by factors released by activated macrophages and glia and is supported by mechanistic studies in dorsal root ganglia (Puehler et al.
T1210 633-656 Sentence denotes 2006; Gabrilovac et al.
T1211 657-663 Sentence denotes 2012).
T1212 664-882 Sentence denotes Since leukocytes, including macrophages, can express β-endorphin and enkephalins, it is important to consider the potential influence of leukocyte-derived endogenous opioid peptides in neuroinflammation (Rittner et al.
T1213 883-889 Sentence denotes 2001).
T1214 890-1060 Sentence denotes Granulocytes express about 10-fold higher levels of β-endorphin, a preferential MOR and lower affinity KOR endogenous ligand, than lymphocytes (Pallinger and Csaba 2008).
T1215 1061-1157 Sentence denotes Increases in β-endorphin expression by peripheral blood mononuclear cells (PBMCs) (Gironi et al.
T1216 1158-1177 Sentence denotes 2000; Gironi et al.
T1217 1178-1246 Sentence denotes 2003), coincide with inflammation and relapse in multiple sclerosis.
T1218 1247-1597 Sentence denotes Moreover, increases in inflammatory cytokines, such as interleukin-1β (IL-1β), have been demonstrated to differentially increase the expression of proenkephalin transcripts in primary astrocytes cultured from different brain regions (Ruzicka and Akil 1997) and increase IL-10-stimulated β-endorphin expression in cultured primary microglia (Wu et al.
T1219 1598-1604 Sentence denotes 2017).
T1220 1605-1698 Sentence denotes Interestingly, OPRM1 mRNA levels do not differ between HIV+ and HIV− subjects (Yuferov et al.
T1221 1699-1705 Sentence denotes 2014).

2_test

Id Subject Object Predicate Lexical cue
32876803-22391864-62958305 106-110 22391864 denotes 2012
32876803-24405578-62958306 127-131 24405578 denotes 2014
32876803-24405578-62958307 211-215 24405578 denotes 2014
32876803-17553897-62958308 272-276 17553897 denotes 2007
32876803-24405578-62958309 442-446 24405578 denotes 2014
32876803-11506126-62958310 883-887 11506126 denotes 2001
32876803-18005034-62958311 1054-1058 18005034 denotes 2008
32876803-29084866-62958312 1598-1602 29084866 denotes 2017
32876803-24405578-62958313 1699-1703 24405578 denotes 2014