PMC:7463108 / 92881-93289 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T876","span":{"begin":37,"end":40},"obj":"Body_part"},{"id":"T877","span":{"begin":97,"end":100},"obj":"Body_part"},{"id":"T878","span":{"begin":350,"end":353},"obj":"Body_part"}],"attributes":[{"id":"A876","pred":"fma_id","subj":"T876","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A877","pred":"fma_id","subj":"T877","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A878","pred":"fma_id","subj":"T878","obj":"http://purl.org/sig/ont/fma/fma278683"}],"text":"Little is known about the effects of HIV on the endogenous opioid system and the extent to which HIV might disrupt the expression and function of opioid peptides and receptors, and vice versa. Because opiate drugs act exclusively by mimicking endogenous peptides and engaging opioid receptors, it is likely that endogenous opioids also interact with HIV to some extent to affect the pathogenesis of neuroHIV."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T936","span":{"begin":153,"end":161},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T937","span":{"begin":254,"end":262},"obj":"http://purl.obolibrary.org/obo/PR_000018263"}],"text":"Little is known about the effects of HIV on the endogenous opioid system and the extent to which HIV might disrupt the expression and function of opioid peptides and receptors, and vice versa. Because opiate drugs act exclusively by mimicking endogenous peptides and engaging opioid receptors, it is likely that endogenous opioids also interact with HIV to some extent to affect the pathogenesis of neuroHIV."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3742","span":{"begin":153,"end":161},"obj":"Chemical"},{"id":"T88543","span":{"begin":208,"end":213},"obj":"Chemical"},{"id":"T375","span":{"begin":254,"end":262},"obj":"Chemical"}],"attributes":[{"id":"A82731","pred":"chebi_id","subj":"T3742","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A35814","pred":"chebi_id","subj":"T88543","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A88128","pred":"chebi_id","subj":"T375","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"Little is known about the effects of HIV on the endogenous opioid system and the extent to which HIV might disrupt the expression and function of opioid peptides and receptors, and vice versa. Because opiate drugs act exclusively by mimicking endogenous peptides and engaging opioid receptors, it is likely that endogenous opioids also interact with HIV to some extent to affect the pathogenesis of neuroHIV."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3273","span":{"begin":37,"end":40},"obj":"Species"},{"id":"3274","span":{"begin":97,"end":100},"obj":"Species"},{"id":"3275","span":{"begin":350,"end":353},"obj":"Species"}],"attributes":[{"id":"A3273","pred":"tao:has_database_id","subj":"3273","obj":"Tax:12721"},{"id":"A3274","pred":"tao:has_database_id","subj":"3274","obj":"Tax:12721"},{"id":"A3275","pred":"tao:has_database_id","subj":"3275","obj":"Tax:12721"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Little is known about the effects of HIV on the endogenous opioid system and the extent to which HIV might disrupt the expression and function of opioid peptides and receptors, and vice versa. Because opiate drugs act exclusively by mimicking endogenous peptides and engaging opioid receptors, it is likely that endogenous opioids also interact with HIV to some extent to affect the pathogenesis of neuroHIV."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T179","span":{"begin":383,"end":395},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"Little is known about the effects of HIV on the endogenous opioid system and the extent to which HIV might disrupt the expression and function of opioid peptides and receptors, and vice versa. Because opiate drugs act exclusively by mimicking endogenous peptides and engaging opioid receptors, it is likely that endogenous opioids also interact with HIV to some extent to affect the pathogenesis of neuroHIV."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1193","span":{"begin":0,"end":192},"obj":"Sentence"},{"id":"T1194","span":{"begin":193,"end":408},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Little is known about the effects of HIV on the endogenous opioid system and the extent to which HIV might disrupt the expression and function of opioid peptides and receptors, and vice versa. Because opiate drugs act exclusively by mimicking endogenous peptides and engaging opioid receptors, it is likely that endogenous opioids also interact with HIV to some extent to affect the pathogenesis of neuroHIV."}