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PMC:7463108 / 87506-92834 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T842 56-60 Body_part denotes Glia http://purl.org/sig/ont/fma/fma54541
T843 110-118 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T844 237-241 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T845 357-360 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T846 370-374 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T847 449-460 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T848 521-524 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T849 783-788 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T850 906-913 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T851 997-1000 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T852 1078-1085 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T853 1110-1141 Body_part denotes glial fibrillary acidic protein http://purl.org/sig/ont/fma/fma63860
T854 1143-1147 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T856 1172-1182 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T857 1338-1342 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T858 1380-1383 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T859 1457-1461 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T860 1496-1500 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T861 1826-1830 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T862 1845-1852 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T863 2506-2510 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T864 2594-2598 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T865 2771-2780 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T866 2846-2850 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T867 2958-2962 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T868 3146-3150 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T869 3281-3285 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T870 4281-4284 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T871 5083-5086 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T872 5095-5099 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T873 5172-5181 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T874 5255-5258 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T170 1354-1359 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T198 4916-4941 Disease denotes neurodegenerative disease http://purl.obolibrary.org/obo/MONDO_0005559

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T907 100-109 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T908 135-136 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T909 228-241 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate cell
T910 370-374 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T911 714-718 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T912 783-788 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T913 850-851 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T914 1094-1095 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T915 1172-1182 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T916 1237-1238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T917 1250-1251 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T918 1338-1342 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T919 1374-1375 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T920 1376-1377 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T921 1626-1630 http://purl.obolibrary.org/obo/CLO_0001545 denotes a 72
T922 2343-2347 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T923 2771-2780 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T924 2846-2850 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T925 4359-4368 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T926 4426-4427 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T927 4499-4503 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T928 4507-4508 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T929 4509-4510 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T930 4627-4631 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T931 4758-4761 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T932 4977-4981 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T933 5070-5079 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T934 5103-5104 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T935 5262-5263 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T37512 110-118 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T67699 389-397 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T334 679-687 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T85477 810-818 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T68690 1011-1019 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T74954 1134-1141 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30670 1394-1402 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T20723 1582-1590 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T15211 1704-1712 Chemical denotes naloxone http://purl.obolibrary.org/obo/CHEBI_7459
T22372 1730-1738 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T96389 1980-1988 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T350 2032-2040 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T37556 2160-2168 Chemical denotes naloxone http://purl.obolibrary.org/obo/CHEBI_7459
T353 2252-2260 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T17637 2476-2478 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T37828 2982-2990 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T7043 3221-3229 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T89089 3445-3453 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T362 3714-3722 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T6684 3830-3838 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61446 3976-3984 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T49943 4086-4094 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T370 4718-4720 Chemical denotes CC http://purl.obolibrary.org/obo/CHEBI_28940
T17030 4845-4853 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3011 16-20 Gene denotes BDNF Gene:627
3012 22-27 Gene denotes mBDNF Gene:12064
3013 41-45 Gene denotes CCR5 Gene:1234
3108 970-974 Gene denotes CCR5 Gene:1234
3109 979-983 Gene denotes BDNF Gene:627
3110 1110-1141 Gene denotes glial fibrillary acidic protein Gene:2670
3111 1143-1147 Gene denotes GFAP Gene:2670
3112 1212-1229 Gene denotes μ-opioid receptor Gene:4988
3113 1231-1234 Gene denotes MOR Gene:4988
3114 1244-1248 Gene denotes CCR5 Gene:1234
3115 1386-1389 Gene denotes Tat Gene:6898
3116 1436-1440 Gene denotes CCR5 Gene:1234
3117 1501-1504 Gene denotes MSN Gene:4478
3118 1518-1521 Gene denotes Tat Gene:6898
3119 1600-1603 Gene denotes Tat Gene:6898
3120 1680-1683 Gene denotes Tat Gene:6898
3121 1866-1869 Gene denotes Tat Gene:6898
3122 2094-2097 Gene denotes Tat Gene:6898
3123 2277-2280 Gene denotes MOR Gene:4988
3124 2533-2537 Gene denotes CCR5 Gene:1234
3125 2568-2572 Gene denotes CCR5 Gene:1234
3126 2604-2608 Gene denotes CCR5 Gene:1234
3127 2658-2662 Gene denotes BDNF Gene:627
3128 2678-2682 Gene denotes BDNF Gene:627
3129 2731-2735 Gene denotes BDNF Gene:627
3130 2782-2787 Gene denotes mBDNF Gene:12064
3131 2858-2863 Gene denotes mBDNF Gene:12064
3132 2872-2876 Gene denotes BDNF Gene:627
3133 2976-2979 Gene denotes Tat Gene:6898
3134 3023-3027 Gene denotes BDNF Gene:627
3135 3032-3037 Gene denotes mBDNF Gene:12064
3136 3068-3072 Gene denotes BDNF Gene:627
3137 3073-3078 Gene denotes mBDNF Gene:12064
3138 3136-3140 Gene denotes CCR5 Gene:1234
3139 3258-3262 Gene denotes BDNF Gene:627
3140 3355-3359 Gene denotes BDNF Gene:627
3141 3360-3365 Gene denotes mBDNF Gene:12064
3142 3486-3490 Gene denotes BDNF Gene:627
3143 3491-3496 Gene denotes mBDNF Gene:12064
3144 3638-3642 Gene denotes CCR5 Gene:1234
3145 3664-3669 Gene denotes mBDNF Gene:12064
3146 3706-3709 Gene denotes Tat Gene:6898
3147 3761-3764 Gene denotes MSN Gene:4478
3148 3805-3808 Gene denotes Tat Gene:6898
3149 3880-3883 Gene denotes Tat Gene:6898
3150 3922-3925 Gene denotes Tat Gene:6898
3151 4017-4022 Gene denotes mBDNF Gene:12064
3152 4078-4081 Gene denotes Tat Gene:6898
3153 4177-4180 Gene denotes Tat Gene:6898
3154 4263-4267 Gene denotes CCR5 Gene:1234
3155 4377-4380 Gene denotes MOR Gene:4988
3156 4395-4399 Gene denotes CCR5 Gene:1234
3157 4413-4416 Gene denotes MOR Gene:4988
3158 4428-4432 Gene denotes BDNF Gene:627
3159 3795-3800 Gene denotes mBDNF Gene:12064
3160 2695-2700 Gene denotes mBDNF Gene:12064
3161 2109-2112 Gene denotes MSN Gene:4478
3162 3822-3825 Gene denotes Tat Gene:6898
3163 3437-3440 Gene denotes Tat Gene:6898
3164 2184-2187 Gene denotes Tat Gene:6898
3165 1003-1006 Gene denotes Tat Gene:6898
3166 997-1002 Species denotes HIV-1 Tax:11676
3167 1380-1385 Species denotes HIV-1 Tax:11676
3168 4281-4286 Species denotes HIV-1 Tax:11676
3169 1011-1019 Chemical denotes morphine MESH:D009020
3170 1394-1402 Chemical denotes morphine MESH:D009020
3171 1582-1590 Chemical denotes morphine MESH:D009020
3172 1704-1712 Chemical denotes naloxone MESH:D009270
3173 1718-1726 Chemical denotes Naloxone MESH:D009270
3174 1730-1738 Chemical denotes morphine MESH:D009020
3175 1980-1988 Chemical denotes morphine MESH:D009020
3176 2032-2040 Chemical denotes morphine MESH:D009020
3177 2160-2168 Chemical denotes naloxone MESH:D009270
3178 2252-2260 Chemical denotes morphine MESH:D009020
3179 2982-2990 Chemical denotes morphine MESH:D009020
3180 3221-3229 Chemical denotes morphine MESH:D009020
3181 3445-3453 Chemical denotes morphine MESH:D009020
3182 3714-3722 Chemical denotes morphine MESH:D009020
3183 3830-3838 Chemical denotes morphine MESH:D009020
3184 3976-3984 Chemical denotes morphine MESH:D009020
3185 4086-4094 Chemical denotes morphine MESH:D009020
3186 1040-1052 Disease denotes cytotoxicity MESH:D064420
3187 1525-1535 Disease denotes neurotoxic MESH:D020258
3188 1612-1620 Disease denotes toxicity MESH:D064420
3189 1813-1830 Disease denotes CCR5-deficit glia MESH:D009461
3190 1952-1960 Disease denotes toxicity MESH:D064420
3191 2188-2196 Disease denotes toxicity MESH:D064420
3192 2354-2364 Disease denotes neurotoxic MESH:D020258
3193 2382-2401 Disease denotes CCR5-deficient MSNs MESH:D007153
3194 2851-2856 Disease denotes death MESH:D003643
3195 2937-2962 Disease denotes CCR5-deficient mixed glia MESH:D060085
3196 3266-3285 Disease denotes CCR5-deficient glia MESH:D007153
3197 3548-3563 Disease denotes CCR5 deficiency MESH:D007153
3198 3894-3904 Disease denotes neurotoxic MESH:D020258
3199 4095-4103 Disease denotes toxicity MESH:D064420
3200 4291-4308 Disease denotes opiate neurotoxic MESH:D020258
3201 4332-4347 Disease denotes CCR5 deficiency MESH:D007153
3223 87-91 Gene denotes BDNF Gene:627
3224 93-98 Gene denotes mBDNF Gene:12064
3225 138-142 Gene denotes TrkB Gene:4915
3226 191-195 Gene denotes BDNF Gene:627
3227 201-205 Gene denotes BDNF Gene:627
3228 213-219 Gene denotes p75NTR Gene:4804
3229 334-338 Gene denotes BDNF Gene:627
3230 430-434 Gene denotes BDNF Gene:627
3231 527-532 Gene denotes gp120 Gene:3700
3232 568-573 Gene denotes mBDNF Gene:12064
3233 628-632 Gene denotes CCR5 Gene:1234
3234 673-676 Gene denotes Tat Gene:6898
3235 802-805 Gene denotes Tat Gene:6898
3236 873-878 Gene denotes mBDNF Gene:12064
3237 921-925 Gene denotes CCR5 Gene:1234
3238 563-567 Gene denotes BDNF Gene:627
3239 521-526 Species denotes HIV-1 Tax:11676
3240 810-818 Chemical denotes morphine MESH:D009020
3241 242-247 Disease denotes death MESH:D003643
3242 357-369 Disease denotes HIV-infected MESH:D015658
3243 730-745 Disease denotes CCR5-deficiency MESH:D007153
3256 4839-4842 Gene denotes Tat Gene:6898
3257 5036-5040 Gene denotes CCR5 Gene:1234
3258 5066-5069 Gene denotes MOR Gene:4988
3259 5105-5109 Gene denotes BDNF Gene:627
3260 5206-5209 Gene denotes MOR Gene:4988
3261 5214-5218 Gene denotes CCR5 Gene:1234
3262 4742-4747 Gene denotes mBDNF Gene:12064
3263 5083-5086 Species denotes HIV Tax:12721
3264 5255-5258 Species denotes HIV Tax:12721
3265 4845-4853 Chemical denotes morphine MESH:D009020
3266 4809-4830 Disease denotes glial CCR5 deficiency MESH:D005910
3267 4916-4941 Disease denotes neurodegenerative disease MESH:D019636

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T171 237-247 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T172 1770-1787 http://purl.obolibrary.org/obo/GO_0043524 denotes neuronal survival
T173 2835-2856 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T174 2846-2856 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T175 4359-4368 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T176 4469-4486 http://purl.obolibrary.org/obo/GO_0043524 denotes neuronal survival
T177 4786-4798 http://purl.obolibrary.org/obo/GO_0043066 denotes pro-survival
T178 5070-5079 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1157 0-79 Sentence denotes Enhanced Mature BDNF (mBDNF) Produced by CCR5 Deficient Glia is Neuroprotective
T1158 80-257 Sentence denotes Mature BDNF (mBDNF) activates tyrosine receptor kinase B (TrkB) and is neuroprotective, while the precursor to BDNF, pro-BDNF, binds p75NTR and can activate cell death pathways.
T1159 258-414 Sentence denotes Based on findings of significant, reversible reductions in glially produced BDNF after exposure to HIV-infected cell supernatant ± morphine (Masvekar et al.
T1160 415-487 Sentence denotes 2014), altered BDNF processing in lymphocytes from PWH (Avdoshina et al.
T1161 488-547 Sentence denotes 2011), and following exposure to HIV-1 gp120 (Bachis et al.
T1162 548-713 Sentence denotes 2012), the pro-BDNF:mBDNF ratio was analyzed in supernatants from wild-type vs. CCR5-null striatal glial cultures exposed to Tat ± morphine for 6 or 24 h (Kim et al.
T1163 714-729 Sentence denotes 2018) (Fig. 6).
T1164 730-954 Sentence denotes CCR5-deficiency reduced this ratio by over 2-fold in cells treated with Tat and morphine after 6 h (Fig. 6), indicating a relative increase in mBDNF that may partially protect neurons in the CCR5-deficient glial environment.
T1165 955-1093 Sentence denotes Fig. 6 Role of CCR5 and BDNF in mediating HIV-1 Tat and morphine-induced interactive cytotoxicity in striatal medium spiny neurons (MSNs).
T1166 1094-1379 Sentence denotes A proportion of glial fibrillary acidic protein (GFAP)-immunolabeled striatal astrocytes display punctate patterns of μ-opioid receptor (MOR) (a) and CCR5 (b) (43.8 ± 2.4%) immunofluorescence—with some faint immunoreactivity extending into the cell processes; scale bars = 10 μm (a-b).
T1167 1380-1468 Sentence denotes HIV-1 Tat and morphine are no longer toxic to MSNs when CCR5 is deleted from glia (c-f).
T1168 1469-1717 Sentence denotes In C57BL/J wild-type mixed glia-MSN co-cultures, Tat is neurotoxic (*p = 0.001 vs. controls), and co-exposure to morphine enhanced Tat-induced toxicity over a 72-h period (**p < 0.001 vs. controls, p < 0.05 vs. Tat) and antagonized by naloxone (c).
T1169 1718-1792 Sentence denotes Naloxone or morphine by themselves had no effect on neuronal survival (c).
T1170 1793-2017 Sentence denotes In co-cultures with CCR5-deficit glia and wild-type neurons, exposure to Tat by itself is significantly toxic (*p < 0.001 vs. controls); however, the enhanced toxicity seen with combined morphine exposure was eliminated (d).
T1171 2018-2140 Sentence denotes Unexpectedly, morphine co-treatment entirely abolished the toxic effects of Tat, restoring MSN survival to control levels.
T1172 2141-2342 Sentence denotes Pre-treatment with naloxone re-established Tat toxicity, suggesting that the paradoxical protective effects of morphine are mediated by MOR (or perhaps another opioid receptor type) (d) (see Kim et al.
T1173 2343-2349 Sentence denotes 2018).
T1174 2350-2475 Sentence denotes The neurotoxic patterns seen in CCR5-deficient MSNs and wild-type glial co-cultures are similar to wild-type co-cultures (e).
T1175 2476-2603 Sentence denotes Co-cultures in which MSNs and glia are both deficient in CCR5 are similar to those in which CCR5 is only deficient in glia (f).
T1176 2604-2730 Sentence denotes CCR5 deletion alters the expression and processing of BDNF precursor (pro-BDNF) to mature (mBDNF) by mixed-glial cultures (g).
T1177 2731-3045 Sentence denotes BDNF is expressed by both astroglia and microglia; mBDNF is neuroprotective, while pro-BDNF can promote programmed cell death. mBDNF and pro-BDNF levels were analyzed in conditioned media from wild-type or CCR5-deficient mixed glia treated with Tat ± morphine after 6 h or 24 h to assess pro-BDNF and mBDNF levels.
T1178 3046-3211 Sentence denotes The proportion of pro-BDNF/mBDNF levels was significantly higher in wild-type compared to CCR5-null glia at 24 h (lower row; g), suggesting reduced neuronal support.
T1179 3212-3414 Sentence denotes Although morphine significantly decreased pro-BDNF in CCR5-deficient glia at both 6 h and 24 h compared to control levels (not shown), the pro-BDNF/mBDNF ratios were unaltered (upper and lower rows; g).
T1180 3415-3653 Sentence denotes By contrast, combined Tat and morphine significantly decreased the pro-BDNF/mBDNF ratio at 6 h, suggesting transient protection with CCR5 deficiency that was not fully sustained at 24 h (p = 0.17) (*p < 0.05, wild-type vs. CCR5-null) (g).
T1181 3654-3737 Sentence denotes Exogenous mBDNF is neuroprotective against combined Tat and morphine treatment (h).
T1182 3738-3879 Sentence denotes Wild-type, mixed glial-MSN co-cultures were treated with mBDNF and Tat, or combined Tat and morphine (represented by dotted survival curves).
T1183 3880-4000 Sentence denotes Tat alone was neurotoxic (*p < 0.05), and Tat was significantly worsened by co-exposing MSNs to morphine (**p < 0.0001).
T1184 4001-4194 Sentence denotes The addition of mBDNF (50 ng/ml; 72 h) fully protected MSNs against combined Tat and morphine toxicity, but only tended to protect (albeit not significantly) MSNs treated with Tat alone (#)(h).
T1185 4195-4498 Sentence denotes Overall, the results in c-h suggest (1) an important role for glial CCR5 in mediating HIV-1 and opiate neurotoxic interactions, (2) that CCR5 deficiency influences signaling through MOR, and (3) that CCR5 (and perhaps MOR) act via a BDNF intermediary to promote or obstruct neuronal survival (Kim et al.
T1186 4499-4731 Sentence denotes 2018). (a-b) Modified and reprinted with permission from Podhaizer et al. (2012). (c-h) Modified and reprinted from Kim et al. (2018), which is an open access article distributed under the terms of the Creative Commons CC BY license
T1187 4732-4960 Sentence denotes Exogenous mBDNF treatment has been found to mimic the pro-survival effect of glial CCR5 deficiency against Tat ± morphine, and its neuroprotective effects have been supported in other neurodegenerative disease models (Cai et al.
T1188 4961-4976 Sentence denotes 2014; Xu et al.
T1189 4977-4983 Sentence denotes 2018).
T1190 4984-5127 Sentence denotes Collectively, the findings suggest that the loss of CCR5 may fundamentally change MOR signaling in HIV-exposed glia in a BDNF-dependent manner.
T1191 5128-5328 Sentence denotes Thus, overall the interaction of opioid and chemokine receptors, specifically MOR and CCR5, may alter the neuropathogenesis of HIV in a qualitatively unique manner not seen with either disorder alone.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T61 4916-4941 Phenotype denotes neurodegenerative disease http://purl.obolibrary.org/obo/HP_0002180

2_test

Id Subject Object Predicate Lexical cue
32876803-24949623-62958291 415-419 24949623 denotes 2014
32876803-21422985-62958292 488-492 21422985 denotes 2011
32876803-22787033-62958293 548-552 22787033 denotes 2012
32876803-22101471-62958294 4574-4578 22101471 denotes 2012
32876803-24818146-62958295 4961-4965 24818146 denotes 2014
32876803-30323150-62958296 4977-4981 30323150 denotes 2018