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PMC:7463108 / 84814-86608 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T818 34-37 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T819 57-61 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T820 121-125 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T821 295-302 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T822 331-338 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T823 632-635 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T824 652-662 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T825 671-680 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T826 875-885 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T827 890-899 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T828 1000-1003 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T829 1013-1023 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T830 1109-1112 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T831 1128-1137 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T832 1283-1292 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T833 1298-1301 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T834 1481-1486 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T835 1505-1508 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T188 638-647 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T189 1443-1452 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T190 1502-1504 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T191 1526-1528 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T192 1559-1561 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T193 1595-1597 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T194 1623-1625 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T876 51-56 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T877 79-80 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T878 121-125 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T879 179-180 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T880 198-199 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T881 230-231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T882 232-240 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T883 405-406 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T884 536-537 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T885 652-662 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T886 671-680 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T887 703-704 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T888 772-780 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T889 875-885 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T890 890-899 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T891 1013-1023 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T892 1128-1137 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T893 1283-1292 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T894 1433-1435 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T895 1481-1486 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T896 1652-1653 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T897 1654-1655 http://purl.obolibrary.org/obo/CLO_0001021 denotes b

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5718 65-74 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T295 99-109 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T15052 168-176 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T60468 295-302 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T47897 331-338 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43994 375-381 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T54004 449-457 Chemical denotes triazole http://purl.obolibrary.org/obo/CHEBI_38597
T59698 481-487 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T303 547-552 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T2279 826-835 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T26201 905-913 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T43395 959-968 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T30455 1040-1048 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T96445 1086-1096 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T81282 1157-1165 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T78388 1309-1317 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T13049 1531-1539 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3701 1564-1573 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T318 1575-1578 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T15381 1604-1607 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T24754 1632-1635 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T5763 1638-1648 Chemical denotes naltrexone http://purl.obolibrary.org/obo/CHEBI_7465

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2881 90-94 Gene denotes CCR5 Gene:1234
2882 95-98 Gene denotes MOR Gene:4988
2883 200-203 Gene denotes MOR Gene:4988
2884 204-208 Gene denotes CCR5 Gene:1234
2885 314-317 Gene denotes MOR Gene:4988
2886 350-354 Gene denotes CCR5 Gene:1234
2887 582-585 Gene denotes MOR Gene:4988
2888 590-594 Gene denotes CCR5 Gene:1234
2889 742-745 Gene denotes Tat Gene:6898
2890 1242-1245 Gene denotes MOR Gene:4988
2891 1250-1254 Gene denotes CCR5 Gene:1234
2892 1776-1780 Gene denotes Hage Gene:55510
2893 1335-1339 Gene denotes Hage Gene:55510
2894 34-39 Species denotes HIV-1 Tax:11676
2895 51-56 Species denotes human Tax:9606
2896 1505-1510 Species denotes HIV-1 Tax:11676
2897 1000-1003 Species denotes HIV Tax:12721
2898 1109-1112 Species denotes HIV Tax:12721
2899 1298-1301 Species denotes HIV Tax:12721
2900 168-176 Chemical denotes morphine MESH:D009020
2901 449-457 Chemical denotes triazole MESH:D014230
2902 905-913 Chemical denotes morphine MESH:D009020
2903 959-968 Chemical denotes maraviroc MESH:D000077592
2904 1040-1048 Chemical denotes morphine MESH:D009020
2905 1157-1165 Chemical denotes morphine MESH:D009020
2906 1309-1317 Chemical denotes morphine MESH:D009020
2907 1531-1539 Chemical denotes morphine MESH:D009020
2908 1638-1648 Chemical denotes naltrexone MESH:D009271
2909 632-647 Disease denotes HIV-1 infection MESH:D015658
2910 1443-1452 Disease denotes infection MESH:D007239
2911 1472-1480 Disease denotes infected MESH:D007239

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T169 1228-1238 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1139 0-284 Sentence denotes Fig. 5 Differential inhibition of HIV-1 entry into human glia by maraviroc and a bivalent CCR5-MOR antagonist (BVL) with cell-specific interactions in combination with morphine. (a) Construction of a MOR-CCR5 heterodimer model in a membrane (gray), and aqueous surrounds (red) system.
T1140 285-620 Sentence denotes The green protein represents MOR and the blue protein represents CCR5, while the bivalent ligand is colored in yellow. (b) Different binding pocket (green) for the triazole moiety of the bivalent ligand yellow) at 0 ns and 6.0 ns. (c) Construction of a chemical probe that interacts with both the MOR and CCR5 receptors simultaneously.
T1141 621-794 Sentence denotes To monitor HIV-1 infection (d) astrocytes and (e) microglia were transfected with a pBlue3′LTR-luc reporter sensitive to Tat expression and luciferase activity was measured.
T1142 795-936 Sentence denotes Data indicate that maraviroc’s antiviral effects are completely negated in both astrocytes and microglia when morphine is present (red bars).
T1143 937-1059 Sentence denotes Interestingly, unlike maraviroc, the bivalent compound blocked HIV entry in astrocytes irrespective of morphine treatment.
T1144 1060-1177 Sentence denotes By contrast, the bivalent antagonist exacerbated HIV infectivity in microglia in the presence of morphine (red bars).
T1145 1178-1346 Sentence denotes The findings reveal fundamental differences in co-regulation of MOR and CCR5 expression in astroglia and microglia upon HIV and/or morphine exposure (see El-Hage et al.
T1146 1347-1353 Sentence denotes 2013).
T1147 1354-1794 Sentence denotes Values are luminescence intensity ± SEM from 3 to 5 independent experiments at 18 h post-infection (*p < 0.005 vs. un-infected cells; $p < 0.05 vs. R5 HIV-1; #p < 0.05 vs. R5 + morphine (M); ¶p < 0.05 vs. R5 + maraviroc (MVC); §p < 0.05 vs. R5 + M + MVC; ¥p < 0.05 vs. R5 + M + MVC + naltrexone). (a–b) Modified and reprinted with permission from Arnatt et al. (2016). (c–e) Modified and reprinted with permission from El-Hage et al. (2013)

2_test

Id Subject Object Predicate Lexical cue
32876803-27720326-62958290 1716-1720 27720326 denotes 2016