PMC:7463108 / 82591-83491 JSONTXT

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    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T788","span":{"begin":58,"end":61},"obj":"Body_part"},{"id":"T789","span":{"begin":104,"end":108},"obj":"Body_part"},{"id":"T790","span":{"begin":126,"end":135},"obj":"Body_part"},{"id":"T791","span":{"begin":163,"end":173},"obj":"Body_part"},{"id":"T792","span":{"begin":214,"end":224},"obj":"Body_part"},{"id":"T793","span":{"begin":269,"end":272},"obj":"Body_part"},{"id":"T794","span":{"begin":350,"end":353},"obj":"Body_part"},{"id":"T795","span":{"begin":367,"end":377},"obj":"Body_part"},{"id":"T796","span":{"begin":500,"end":509},"obj":"Body_part"},{"id":"T797","span":{"begin":641,"end":652},"obj":"Body_part"},{"id":"T798","span":{"begin":653,"end":662},"obj":"Body_part"},{"id":"T799","span":{"begin":835,"end":845},"obj":"Body_part"},{"id":"T800","span":{"begin":858,"end":867},"obj":"Body_part"}],"attributes":[{"id":"A788","pred":"fma_id","subj":"T788","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A789","pred":"fma_id","subj":"T789","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A790","pred":"fma_id","subj":"T790","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A791","pred":"fma_id","subj":"T791","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A792","pred":"fma_id","subj":"T792","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A793","pred":"fma_id","subj":"T793","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A794","pred":"fma_id","subj":"T794","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A795","pred":"fma_id","subj":"T795","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A796","pred":"fma_id","subj":"T796","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A797","pred":"fma_id","subj":"T797","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A798","pred":"fma_id","subj":"T798","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A799","pred":"fma_id","subj":"T799","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A800","pred":"fma_id","subj":"T800","obj":"http://purl.org/sig/ont/fma/fma68923"}],"text":"The ability of opiates to modulate CCR5 expression in the CNS has been demonstrated to occur in various cell types, including microglia (Bokhari et al. 2009), and astrocytes (Mahajan et al. 2002). Specifically, in astrocytes MOR activation enhanced CCR5 and additional HIV-1 entry co-receptor (CCR3 and CXCR2) expression, whereas local production of HIV-1 protective chemokines (IL-8, CCL4) was inhibited (Mahajan et al. 2002). Deletion of CCR5 significantly attenuates morphine-induced increases in astrocyte CCL2 immunoreactivity in Tat transgenic mice (El-Hage et al. 2008a) (Fig. 1). Interestingly, the proportion of CCL2 immunoreactive macrophages/microglia in CCL5(−/−) mice after Tat and morphine co-administration still showed a significant upregulation, suggesting CCL5 regulates Tat and morphine-induced increases in CCL2 in astrocytes, but not in microglia (El-Hage et al. 2008a) (Fig. 1)."}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T169","span":{"begin":58,"end":61},"obj":"Body_part"}],"attributes":[{"id":"A169","pred":"uberon_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"}],"text":"The ability of opiates to modulate CCR5 expression in the CNS has been demonstrated to occur in various cell types, including microglia (Bokhari et al. 2009), and astrocytes (Mahajan et al. 2002). Specifically, in astrocytes MOR activation enhanced CCR5 and additional HIV-1 entry co-receptor (CCR3 and CXCR2) expression, whereas local production of HIV-1 protective chemokines (IL-8, CCL4) was inhibited (Mahajan et al. 2002). Deletion of CCR5 significantly attenuates morphine-induced increases in astrocyte CCL2 immunoreactivity in Tat transgenic mice (El-Hage et al. 2008a) (Fig. 1). Interestingly, the proportion of CCL2 immunoreactive macrophages/microglia in CCL5(−/−) mice after Tat and morphine co-administration still showed a significant upregulation, suggesting CCL5 regulates Tat and morphine-induced increases in CCL2 in astrocytes, but not in microglia (El-Hage et al. 2008a) (Fig. 1)."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T848","span":{"begin":58,"end":61},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T849","span":{"begin":58,"end":61},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T850","span":{"begin":58,"end":61},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T851","span":{"begin":62,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T852","span":{"begin":104,"end":114},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T853","span":{"begin":126,"end":135},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T854","span":{"begin":163,"end":173},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T855","span":{"begin":214,"end":224},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T856","span":{"begin":229,"end":239},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T857","span":{"begin":379,"end":383},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T858","span":{"begin":500,"end":509},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T859","span":{"begin":653,"end":662},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T860","span":{"begin":735,"end":736},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T861","span":{"begin":835,"end":845},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T862","span":{"begin":858,"end":867},"obj":"http://purl.obolibrary.org/obo/CL_0000129"}],"text":"The ability of opiates to modulate CCR5 expression in the CNS has been demonstrated to occur in various cell types, including microglia (Bokhari et al. 2009), and astrocytes (Mahajan et al. 2002). Specifically, in astrocytes MOR activation enhanced CCR5 and additional HIV-1 entry co-receptor (CCR3 and CXCR2) expression, whereas local production of HIV-1 protective chemokines (IL-8, CCL4) was inhibited (Mahajan et al. 2002). Deletion of CCR5 significantly attenuates morphine-induced increases in astrocyte CCL2 immunoreactivity in Tat transgenic mice (El-Hage et al. 2008a) (Fig. 1). Interestingly, the proportion of CCL2 immunoreactive macrophages/microglia in CCL5(−/−) mice after Tat and morphine co-administration still showed a significant upregulation, suggesting CCL5 regulates Tat and morphine-induced increases in CCL2 in astrocytes, but not in microglia (El-Hage et al. 2008a) (Fig. 1)."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T75121","span":{"begin":379,"end":381},"obj":"Chemical"},{"id":"T89703","span":{"begin":470,"end":478},"obj":"Chemical"},{"id":"T17203","span":{"begin":695,"end":703},"obj":"Chemical"},{"id":"T275","span":{"begin":797,"end":805},"obj":"Chemical"}],"attributes":[{"id":"A26755","pred":"chebi_id","subj":"T75121","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A78378","pred":"chebi_id","subj":"T75121","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A59576","pred":"chebi_id","subj":"T89703","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A94338","pred":"chebi_id","subj":"T89703","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A11357","pred":"chebi_id","subj":"T17203","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A69951","pred":"chebi_id","subj":"T17203","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A44233","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A10420","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"}],"text":"The ability of opiates to modulate CCR5 expression in the CNS has been demonstrated to occur in various cell types, including microglia (Bokhari et al. 2009), and astrocytes (Mahajan et al. 2002). Specifically, in astrocytes MOR activation enhanced CCR5 and additional HIV-1 entry co-receptor (CCR3 and CXCR2) expression, whereas local production of HIV-1 protective chemokines (IL-8, CCL4) was inhibited (Mahajan et al. 2002). Deletion of CCR5 significantly attenuates morphine-induced increases in astrocyte CCL2 immunoreactivity in Tat transgenic mice (El-Hage et al. 2008a) (Fig. 1). Interestingly, the proportion of CCL2 immunoreactive macrophages/microglia in CCL5(−/−) mice after Tat and morphine co-administration still showed a significant upregulation, suggesting CCL5 regulates Tat and morphine-induced increases in CCL2 in astrocytes, but not in microglia (El-Hage et al. 2008a) (Fig. 1)."}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"2825","span":{"begin":35,"end":39},"obj":"Gene"},{"id":"2826","span":{"begin":225,"end":228},"obj":"Gene"},{"id":"2827","span":{"begin":249,"end":253},"obj":"Gene"},{"id":"2828","span":{"begin":294,"end":298},"obj":"Gene"},{"id":"2829","span":{"begin":303,"end":308},"obj":"Gene"},{"id":"2830","span":{"begin":379,"end":383},"obj":"Gene"},{"id":"2831","span":{"begin":385,"end":389},"obj":"Gene"},{"id":"2832","span":{"begin":440,"end":444},"obj":"Gene"},{"id":"2833","span":{"begin":510,"end":514},"obj":"Gene"},{"id":"2834","span":{"begin":535,"end":538},"obj":"Gene"},{"id":"2835","span":{"begin":621,"end":625},"obj":"Gene"},{"id":"2836","span":{"begin":666,"end":670},"obj":"Gene"},{"id":"2837","span":{"begin":774,"end":778},"obj":"Gene"},{"id":"2838","span":{"begin":789,"end":792},"obj":"Gene"},{"id":"2839","span":{"begin":827,"end":831},"obj":"Gene"},{"id":"2840","span":{"begin":687,"end":690},"obj":"Gene"},{"id":"2841","span":{"begin":872,"end":876},"obj":"Gene"},{"id":"2842","span":{"begin":559,"end":563},"obj":"Gene"},{"id":"2843","span":{"begin":269,"end":274},"obj":"Species"},{"id":"2844","span":{"begin":350,"end":355},"obj":"Species"},{"id":"2845","span":{"begin":539,"end":554},"obj":"Species"},{"id":"2846","span":{"begin":676,"end":680},"obj":"Species"},{"id":"2847","span":{"begin":470,"end":478},"obj":"Chemical"},{"id":"2848","span":{"begin":695,"end":703},"obj":"Chemical"},{"id":"2849","span":{"begin":797,"end":805},"obj":"Chemical"}],"attributes":[{"id":"A2825","pred":"tao:has_database_id","subj":"2825","obj":"Gene:1234"},{"id":"A2826","pred":"tao:has_database_id","subj":"2826","obj":"Gene:4988"},{"id":"A2827","pred":"tao:has_database_id","subj":"2827","obj":"Gene:1234"},{"id":"A2828","pred":"tao:has_database_id","subj":"2828","obj":"Gene:1232"},{"id":"A2829","pred":"tao:has_database_id","subj":"2829","obj":"Gene:3579"},{"id":"A2830","pred":"tao:has_database_id","subj":"2830","obj":"Gene:3576"},{"id":"A2831","pred":"tao:has_database_id","subj":"2831","obj":"Gene:6351"},{"id":"A2832","pred":"tao:has_database_id","subj":"2832","obj":"Gene:12774"},{"id":"A2833","pred":"tao:has_database_id","subj":"2833","obj":"Gene:20296"},{"id":"A2834","pred":"tao:has_database_id","subj":"2834","obj":"Gene:234724"},{"id":"A2835","pred":"tao:has_database_id","subj":"2835","obj":"Gene:20296"},{"id":"A2836","pred":"tao:has_database_id","subj":"2836","obj":"Gene:20304"},{"id":"A2837","pred":"tao:has_database_id","subj":"2837","obj":"Gene:20304"},{"id":"A2838","pred":"tao:has_database_id","subj":"2838","obj":"Gene:234724"},{"id":"A2839","pred":"tao:has_database_id","subj":"2839","obj":"Gene:20296"},{"id":"A2840","pred":"tao:has_database_id","subj":"2840","obj":"Gene:234724"},{"id":"A2841","pred":"tao:has_database_id","subj":"2841","obj":"Gene:55510"},{"id":"A2842","pred":"tao:has_database_id","subj":"2842","obj":"Gene:55510"},{"id":"A2843","pred":"tao:has_database_id","subj":"2843","obj":"Tax:11676"},{"id":"A2844","pred":"tao:has_database_id","subj":"2844","obj":"Tax:11676"},{"id":"A2845","pred":"tao:has_database_id","subj":"2845","obj":"Tax:10090"},{"id":"A2846","pred":"tao:has_database_id","subj":"2846","obj":"Tax:10090"},{"id":"A2847","pred":"tao:has_database_id","subj":"2847","obj":"MESH:D009020"},{"id":"A2848","pred":"tao:has_database_id","subj":"2848","obj":"MESH:D009020"},{"id":"A2849","pred":"tao:has_database_id","subj":"2849","obj":"MESH:D009020"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The ability of opiates to modulate CCR5 expression in the CNS has been demonstrated to occur in various cell types, including microglia (Bokhari et al. 2009), and astrocytes (Mahajan et al. 2002). Specifically, in astrocytes MOR activation enhanced CCR5 and additional HIV-1 entry co-receptor (CCR3 and CXCR2) expression, whereas local production of HIV-1 protective chemokines (IL-8, CCL4) was inhibited (Mahajan et al. 2002). Deletion of CCR5 significantly attenuates morphine-induced increases in astrocyte CCL2 immunoreactivity in Tat transgenic mice (El-Hage et al. 2008a) (Fig. 1). Interestingly, the proportion of CCL2 immunoreactive macrophages/microglia in CCL5(−/−) mice after Tat and morphine co-administration still showed a significant upregulation, suggesting CCL5 regulates Tat and morphine-induced increases in CCL2 in astrocytes, but not in microglia (El-Hage et al. 2008a) (Fig. 1)."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T1120","span":{"begin":0,"end":151},"obj":"Sentence"},{"id":"T1121","span":{"begin":152,"end":189},"obj":"Sentence"},{"id":"T1122","span":{"begin":190,"end":196},"obj":"Sentence"},{"id":"T1123","span":{"begin":197,"end":420},"obj":"Sentence"},{"id":"T1124","span":{"begin":421,"end":427},"obj":"Sentence"},{"id":"T1125","span":{"begin":428,"end":570},"obj":"Sentence"},{"id":"T1126","span":{"begin":571,"end":587},"obj":"Sentence"},{"id":"T1127","span":{"begin":588,"end":883},"obj":"Sentence"},{"id":"T1128","span":{"begin":884,"end":900},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The ability of opiates to modulate CCR5 expression in the CNS has been demonstrated to occur in various cell types, including microglia (Bokhari et al. 2009), and astrocytes (Mahajan et al. 2002). Specifically, in astrocytes MOR activation enhanced CCR5 and additional HIV-1 entry co-receptor (CCR3 and CXCR2) expression, whereas local production of HIV-1 protective chemokines (IL-8, CCL4) was inhibited (Mahajan et al. 2002). Deletion of CCR5 significantly attenuates morphine-induced increases in astrocyte CCL2 immunoreactivity in Tat transgenic mice (El-Hage et al. 2008a) (Fig. 1). Interestingly, the proportion of CCL2 immunoreactive macrophages/microglia in CCL5(−/−) mice after Tat and morphine co-administration still showed a significant upregulation, suggesting CCL5 regulates Tat and morphine-induced increases in CCL2 in astrocytes, but not in microglia (El-Hage et al. 2008a) (Fig. 1)."}