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PMC:7463108 / 80662-82590 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T776 35-38 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T777 53-56 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T778 168-177 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T779 528-537 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T780 746-755 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T781 1020-1024 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T782 1229-1238 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T783 1271-1281 Body_part denotes enkephalin http://purl.org/sig/ont/fma/fma83367
T784 1383-1386 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T785 1766-1769 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T786 1789-1798 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T787 1867-1870 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T185 35-48 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T186 39-48 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T187 1356-1358 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T835 422-431 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T836 657-667 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T837 746-755 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T838 886-896 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T839 1141-1142 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T840 1229-1238 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T841 1291-1292 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T842 1492-1495 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T843 1529-1538 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T844 1627-1637 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T845 1641-1642 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T846 1780-1788 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T847 1808-1817 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T7532 1263-1266 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T266 1283-1288 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T91089 1297-1303 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T50812 1882-1886 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2763 202-205 Gene denotes MOR Gene:4988
2764 210-214 Gene denotes CCR5 Gene:1234
2765 218-223 Gene denotes CXCR4 Gene:7852
2766 645-648 Gene denotes MOR Gene:4988
2767 653-656 Gene denotes DOR Gene:58476
2768 699-703 Gene denotes CCR5 Gene:1234
2769 722-726 Gene denotes CCL3 Gene:6348
2770 728-732 Gene denotes CCL4 Gene:6351
2771 738-742 Gene denotes CCL5 Gene:6352
2772 867-870 Gene denotes MOR Gene:4988
2773 881-885 Gene denotes PKCζ Gene:5590
2774 901-905 Gene denotes CCR5 Gene:1234
2775 976-979 Gene denotes MOR Gene:4988
2776 1006-1010 Gene denotes CCL2 Gene:6347
2777 1015-1019 Gene denotes CCL4 Gene:6351
2778 1096-1101 Gene denotes CCR2b Gene:729230
2779 1103-1107 Gene denotes CCR3 Gene:1232
2780 1113-1117 Gene denotes CCR5 Gene:1234
2781 1195-1199 Gene denotes CCR5 Gene:1234
2782 1204-1209 Gene denotes CXCR4 Gene:7852
2783 1224-1228 Gene denotes CD14 Gene:929
2784 1293-1296 Gene denotes MOR Gene:4988
2785 1413-1418 Gene denotes CXCR4 Gene:7852
2786 1484-1487 Gene denotes MOR Gene:4988
2787 1514-1517 Gene denotes KOR Gene:4986
2788 1614-1617 Gene denotes KOR Gene:4986
2789 1621-1626 Gene denotes CXCR4 Gene:7852
2790 1789-1807 Gene denotes chemokine receptor Gene:7852
2791 1383-1386 Species denotes HIV Tax:12721
2792 1766-1769 Species denotes HIV Tax:12721
2793 1867-1870 Species denotes HIV Tax:12721
2794 528-546 Gene denotes chemokine receptor Gene:7852
2795 1253-1261 Chemical denotes N-MePhe4
2796 1263-1281 Chemical denotes Gly-ol]-enkephalin
2797 1524-1528 Chemical denotes Ca2+ MESH:D000069285
2798 35-48 Disease denotes HIV infection MESH:D015658
2799 53-74 Disease denotes HIV neuropathogenesis MESH:D015658

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T160 218-223 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T161 422-431 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T162 906-921 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T163 1204-1209 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T164 1413-1418 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T165 1529-1538 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T166 1621-1626 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T167 1808-1817 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1098 0-264 Sentence denotes The ability of opiates to modulate HIV infection and HIV neuropathogenesis/disease progression may be partly due to the interactive effects seen between the opioid and chemokine receptors, specifically MOR and CCR5 or CXCR4 (Rogers and Peterson 2003; Steele et al.
T1099 265-283 Sentence denotes 2003; Szabo et al.
T1100 284-313 Sentence denotes 2003; Festa and Meucci 2012).
T1101 314-446 Sentence denotes The potential mechanisms for this interaction can include heterologous cross-desensitization via downstream signaling (Rogers et al.
T1102 447-466 Sentence denotes 2000; Steele et al.
T1103 467-484 Sentence denotes 2002; Song et al.
T1104 485-597 Sentence denotes 2011) and/or potentially via direct opioid-chemokine receptor dimeric or heteromeric interactions (Suzuki et al.
T1105 598-615 Sentence denotes 2002; Chen et al.
T1106 616-644 Sentence denotes 2004; Nash and Meucci 2014).
T1107 645-769 Sentence denotes MOR and DOR activation can heterologously desensitize CCR5 responsiveness to CCL3, CCL4, and CCL5 in monocytes (Grimm et al.
T1108 770-788 Sentence denotes 1998; Szabo et al.
T1109 789-806 Sentence denotes 2003; Chen et al.
T1110 807-813 Sentence denotes 2004).
T1111 814-953 Sentence denotes The cross-desensitization appears to be regulated by MOR-dependent PKCζ activation and CCR5 phosphorylation and downregulation (Song et al.
T1112 954-960 Sentence denotes 2011).
T1113 961-1133 Sentence denotes Alternatively, MOR-induced downregulation of CCL2 and CCL4 mRNA reciprocally upregulates the expression of their associated receptors, CCR2b, CCR3, and CCR5 (Mahajan et al.
T1114 1134-1140 Sentence denotes 2005).
T1115 1141-1401 Sentence denotes A previous study reported significant upregulation of CCR5 and CXCR4 expression in CD14 monocytes with [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO), a MOR ligand, exposure with enhanced replication of both X4- and R5-tropic viral strains of HIV (Steele et al.
T1116 1402-1408 Sentence denotes 2003).
T1117 1409-1688 Sentence denotes For CXCR4, bidirectional heterologous desensitization is less evident with MOR but has been reported for KOR, with Ca2+ signaling experiments suggesting that cross-desensitization occurs within seconds of KOR or CXCR4 activation in a concentration-dependent manner (Finley et al.
T1118 1689-1695 Sentence denotes 2008).
T1119 1696-1928 Sentence denotes Thus, opiates acting at different opioid receptors in the presence of HIV appear to activate chemokine receptor signaling and can contribute to the synergistic effects of HIV and opioid drug co-exposure seen in neuroHIV progression.

2_test

Id Subject Object Predicate Lexical cue
32876803-12615205-62958273 245-249 12615205 denotes 2003
32876803-12726730-62958274 265-269 12726730 denotes 2003
32876803-12972507-62958275 284-288 12972507 denotes 2003
32876803-22591369-62958276 307-311 22591369 denotes 2012
32876803-11268344-62958277 447-451 11268344 denotes 2000
32876803-12486875-62958278 467-471 12486875 denotes 2002
32876803-21454526-62958279 485-489 21454526 denotes 2011
32876803-12413885-62958280 598-602 12413885 denotes 2002
32876803-14729105-62958281 616-620 14729105 denotes 2004
32876803-9670044-62958282 770-774 9670044 denotes 1998
32876803-12972507-62958283 789-793 12972507 denotes 2003
32876803-14729105-62958284 807-811 14729105 denotes 2004
32876803-21454526-62958285 954-958 21454526 denotes 2011
32876803-15893700-62958286 1134-1138 15893700 denotes 2005
32876803-12726730-62958287 1402-1406 12726730 denotes 2003