PMC:7463108 / 8030-9622
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T53390 | 222-243 | Body_part | denotes | hippocampal formation | http://purl.org/sig/ont/fma/fma74038 |
| T3876 | 260-279 | Body_part | denotes | Purkinje cell layer | http://purl.org/sig/ont/fma/fma83896 |
| T20293 | 260-273 | Body_part | denotes | Purkinje cell | http://purl.org/sig/ont/fma/fma67969 |
| T85401 | 269-273 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T76845 | 427-434 | Body_part | denotes | neurons | http://purl.org/sig/ont/fma/fma54527 |
| T87068 | 539-544 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T38234 | 649-662 | Body_part | denotes | basal ganglia | http://purl.org/sig/ont/fma/fma84013 |
| T68160 | 691-708 | Body_part | denotes | prefrontal cortex | http://purl.org/sig/ont/fma/fma224850 |
| T55578 | 734-746 | Body_part | denotes | hypothalamus | http://purl.org/sig/ont/fma/fma62008 |
| T64557 | 1042-1050 | Body_part | denotes | Glycogen | http://purl.org/sig/ont/fma/fma82747 |
| T92926 | 1095-1103 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T42648 | 1256-1271 | Body_part | denotes | locus coeruleus | http://purl.org/sig/ont/fma/fma72478 |
| T92921 | 1281-1292 | Body_part | denotes | hippocampus | http://purl.org/sig/ont/fma/fma275020 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T14 | 222-243 | Body_part | denotes | hippocampal formation | http://purl.obolibrary.org/obo/UBERON_0002421 |
| T15 | 269-279 | Body_part | denotes | cell layer | http://purl.obolibrary.org/obo/UBERON_0000119 |
| T16 | 539-544 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T17 | 691-708 | Body_part | denotes | prefrontal cortex | http://purl.obolibrary.org/obo/UBERON_0000451 |
| T18 | 702-708 | Body_part | denotes | cortex | http://purl.obolibrary.org/obo/UBERON_0001851 |
| T19 | 734-746 | Body_part | denotes | hypothalamus | http://purl.obolibrary.org/obo/UBERON_0001898 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T16 | 89-112 | Disease | denotes | neurovascular disorders | http://purl.obolibrary.org/obo/MONDO_0043218 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T28968 | 40-41 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T341 | 269-279 | http://purl.obolibrary.org/obo/UBERON_0000119 | denotes | cell layer |
| T98752 | 539-544 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T24863 | 539-544 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T98993 | 702-708 | http://purl.obolibrary.org/obo/UBERON_0001851 | denotes | cortex |
| T84522 | 762-766 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T33224 | 1091-1094 | http://purl.obolibrary.org/obo/NCBITaxon_9596 | denotes | pan |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T34 | 12-18 | Chemical | denotes | heroin | http://purl.obolibrary.org/obo/CHEBI_27808 |
| T35 | 292-299 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T36 | 868-871 | Chemical | denotes | tau | http://purl.obolibrary.org/obo/CHEBI_36355 |
| T37 | 1042-1050 | Chemical | denotes | Glycogen | http://purl.obolibrary.org/obo/CHEBI_28087 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 143 | 1077-1085 | Gene | denotes | GSK-3α/β | Gene:2931 |
| 144 | 1166-1191 | Gene | denotes | cyclin-dependent kinase-5 | Gene:1020 |
| 145 | 1193-1198 | Gene | denotes | Cdk-5 | Gene:1020 |
| 146 | 1091-1094 | Gene | denotes | pan | Gene:51816 |
| 147 | 12-18 | Chemical | denotes | heroin | MESH:D003932 |
| 148 | 19-33 | Disease | denotes | overdose death | MESH:D062787 |
| 149 | 89-112 | Disease | denotes | neurovascular disorders | MESH:D013901 |
| 150 | 114-150 | Disease | denotes | hypoxic ischemic leukoencephalopathy | MESH:D056784 |
| 151 | 172-179 | Disease | denotes | atrophy | MESH:D001284 |
| 152 | 734-746 | Disease | denotes | hypothalamus | MESH:D007029 |
| 153 | 784-803 | Disease | denotes | leukoencephalopathy | MESH:D056784 |
| 154 | 805-812 | Disease | denotes | atrophy | MESH:D001284 |
| 155 | 933-945 | Disease | denotes | opiate abuse | MESH:D009293 |
| 156 | 1446-1457 | Disease | denotes | Alzheimer’s | MESH:D000544 |
| 157 | 1550-1570 | Disease | denotes | cognitive impairment | MESH:D003072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T51458 | 234-243 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T8927 | 1166-1172 | http://purl.obolibrary.org/obo/GO_0016538 | denotes | cyclin |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T76 | 0-330 | Sentence | denotes | For delayed heroin overdose death after a survival period of 5 h or more, studies report neurovascular disorders, hypoxic ischemic leukoencephalopathy, and region-specific atrophy with neuronal losses that can include the hippocampal formation, the cerebellar Purkinje cell layer and olivary nucleus (Protass 1971; Ginsberg et al. |
| T77 | 331-353 | Sentence | denotes | 1976; Gosztonyi et al. |
| T78 | 354-411 | Sentence | denotes | 1993), as well as other areas (Buttner 2011; Cadet et al. |
| T79 | 412-418 | Sentence | denotes | 2014). |
| T80 | 419-616 | Sentence | denotes | Loss of neurons and synaptic connections is supported by postmortem reports of smaller mean relative volumes in various brain regions in individuals with OUD, including cortical areas (Danos et al. |
| T81 | 617-637 | Sentence | denotes | 1998; Pezawas et al. |
| T82 | 638-677 | Sentence | denotes | 1998), the basal ganglia (Muller et al. |
| T83 | 678-722 | Sentence | denotes | 2015, 2019), prefrontal cortex (Cadet et al. |
| T84 | 723-761 | Sentence | denotes | 2014), and hypothalamus (Muller et al. |
| T85 | 762-768 | Sentence | denotes | 2018). |
| T86 | 769-826 | Sentence | denotes | Interestingly, leukoencephalopathy, atrophy (Cadet et al. |
| T87 | 827-993 | Sentence | denotes | 2014), and increased hyperphosphorylated tau-containing neurofibrillary tangles are reported with chronic opiate abuse compared to age-matched controls (Ramage et al. |
| T88 | 994-1014 | Sentence | denotes | 2005; Anthony et al. |
| T89 | 1015-1034 | Sentence | denotes | 2010; Kovacs et al. |
| T90 | 1035-1041 | Sentence | denotes | 2015). |
| T91 | 1042-1355 | Sentence | denotes | Glycogen synthase kinase 3 α or β (GSK-3α/β; the pan antibody used in this study does not discern α from β isoforms) and/or cyclin-dependent kinase-5 (Cdk-5) are increased in the frontal and temporal cortices, the locus coeruleus, and the hippocampus, respectively, and correlate with microgliosis (Anthony et al. |
| T92 | 1356-1362 | Sentence | denotes | 2010). |
| T93 | 1363-1498 | Sentence | denotes | Further, more prolonged use increases the risk of accelerated age-related and even Alzheimer’s-like pathological changes (Ramage et al. |
| T94 | 1499-1519 | Sentence | denotes | 2005; Anthony et al. |
| T95 | 1520-1539 | Sentence | denotes | 2010; Kovacs et al. |
| T96 | 1540-1585 | Sentence | denotes | 2015) and cognitive impairment (Gruber et al. |
| T97 | 1586-1592 | Sentence | denotes | 2007). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T12 | 131-150 | Phenotype | denotes | leukoencephalopathy | http://purl.obolibrary.org/obo/HP_0002352 |
| T13 | 185-200 | Phenotype | denotes | neuronal losses | http://purl.obolibrary.org/obo/HP_0002529 |
| T14 | 784-803 | Phenotype | denotes | leukoencephalopathy | http://purl.obolibrary.org/obo/HP_0002352 |
| T15 | 883-906 | Phenotype | denotes | neurofibrillary tangles | http://purl.obolibrary.org/obo/HP_0002185 |
| T16 | 1550-1570 | Phenotype | denotes | cognitive impairment | http://purl.obolibrary.org/obo/HP_0100543 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32876803-5559439-62957859 | 309-313 | 5559439 | denotes | 1971 |
| 32876803-1247396-62957860 | 331-335 | 1247396 | denotes | 1976 |
| 32876803-8300019-62957861 | 354-358 | 8300019 | denotes | 1993 |
| 32876803-20946118-62957862 | 393-397 | 20946118 | denotes | 2011 |
| 32876803-24292887-62957863 | 412-416 | 24292887 | denotes | 2014 |
| 32876803-9732207-62957864 | 617-621 | 9732207 | denotes | 1998 |
| 32876803-9849723-62957865 | 638-642 | 9849723 | denotes | 1998 |
| 32876803-26189034-62957866 | 678-682 | 26189034 | denotes | 2015 |
| 32876803-30173319-62957867 | 684-688 | 30173319 | denotes | 2019 |
| 32876803-24292887-62957868 | 723-727 | 24292887 | denotes | 2014 |
| 32876803-28534187-62957869 | 762-766 | 28534187 | denotes | 2018 |
| 32876803-24292887-62957870 | 827-831 | 24292887 | denotes | 2014 |
| 32876803-16008828-62957871 | 994-998 | 16008828 | denotes | 2005 |
| 32876803-21126996-62957872 | 1015-1019 | 21126996 | denotes | 2010 |
| 32876803-26254956-62957873 | 1035-1039 | 26254956 | denotes | 2015 |
| 32876803-21126996-62957874 | 1356-1360 | 21126996 | denotes | 2010 |
| 32876803-16008828-62957875 | 1499-1503 | 16008828 | denotes | 2005 |
| 32876803-21126996-62957876 | 1520-1524 | 21126996 | denotes | 2010 |
| 32876803-26254956-62957877 | 1540-1544 | 26254956 | denotes | 2015 |
| 32876803-17690984-62957878 | 1586-1590 | 17690984 | denotes | 2007 |