PMC:7463108 / 76-1528
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T36418 | 161-164 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T60544 | 185-207 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
| T59550 | 209-212 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
| T34528 | 362-365 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T34449 | 539-542 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T43923 | 580-584 | Body_part | denotes | HAND | http://purl.org/sig/ont/fma/fma9712 |
| T63421 | 728-731 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T26171 | 761-764 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T51689 | 777-781 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T88958 | 973-976 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T13436 | 1163-1166 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T69159 | 1234-1237 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T39171 | 1238-1247 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 185-207 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T2 | 193-207 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
| T3 | 209-212 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 137-153 | Disease | denotes | immunodeficiency | http://purl.obolibrary.org/obo/MONDO_0021094 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9974 | 131-136 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T45969 | 154-159 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T24986 | 185-207 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
| T38936 | 185-207 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
| T51456 | 185-207 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
| T39921 | 209-212 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T78273 | 209-212 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T61752 | 209-212 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
| T57883 | 777-781 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T35359 | 899-900 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T81874 | 901-906 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focus |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 11 | 1206-1223 | Gene | denotes | μ-opioid receptor | Gene:4988 |
| 12 | 1225-1228 | Gene | denotes | MOR | Gene:4988 |
| 13 | 131-159 | Species | denotes | human immunodeficiency virus | Tax:12721 |
| 14 | 761-766 | Species | denotes | HIV-1 | Tax:11676 |
| 15 | 1163-1168 | Species | denotes | HIV-1 | Tax:11676 |
| 16 | 161-164 | Species | denotes | HIV | Tax:12721 |
| 17 | 362-365 | Species | denotes | HIV | Tax:12721 |
| 18 | 728-731 | Species | denotes | HIV | Tax:12721 |
| 19 | 973-976 | Species | denotes | HIV | Tax:12721 |
| 20 | 1234-1237 | Species | denotes | HIV | Tax:12721 |
| 21 | 526-578 | Disease | denotes | neuroHIV and HIV-associated neurocognitive disorders | MESH:D020943 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T96803 | 989-1001 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-214 | Sentence | denotes | With the current national opioid crisis, it is critical to examine the mechanisms underlying pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in the central nervous system (CNS). |
| T4 | 215-403 | Sentence | denotes | Recent advances in experimental models, methodology, and our understanding of disease processes at the molecular and cellular levels reveal opioid-HIV interactions with increasing clarity. |
| T5 | 404-611 | Sentence | denotes | However, despite the substantial new insight, the unique impact of opioids on the severity, progression, and prognosis of neuroHIV and HIV-associated neurocognitive disorders (HAND) are not fully understood. |
| T6 | 612-837 | Sentence | denotes | In this review, we explore, in detail, what is currently known about mechanisms underlying opioid interactions with HIV, with emphasis on individual HIV-1-expressed gene products at the molecular, cellular and systems levels. |
| T7 | 838-1089 | Sentence | denotes | Furthermore, we review preclinical and clinical studies with a focus on key considerations when addressing questions of whether opioid-HIV interactive pathogenesis results in unique structural or functional deficits not seen with either disease alone. |
| T8 | 1090-1292 | Sentence | denotes | These considerations include, understanding the combined consequences of HIV-1 genetic variants, host variants, and μ-opioid receptor (MOR) and HIV chemokine co-receptor interactions on the comorbidity. |
| T9 | 1293-1452 | Sentence | denotes | Lastly, we present topics that need to be considered in the future to better understand the unique contributions of opioids to the pathophysiology of neuroHIV. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 137-153 | Phenotype | denotes | immunodeficiency | http://purl.obolibrary.org/obo/HP_0002721 |