PMC:7463108 / 72924-73537 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T711","span":{"begin":161,"end":164},"obj":"Body_part"},{"id":"T712","span":{"begin":597,"end":600},"obj":"Body_part"}],"attributes":[{"id":"A711","pred":"fma_id","subj":"T711","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A712","pred":"fma_id","subj":"T712","obj":"http://purl.org/sig/ont/fma/fma278683"}],"text":"The interplay of complex host and viral genetic differences is likely to play a huge role in determining pathologic outcomes in PWH. For example, differences in HIV strains/variants (Rao et al. 2013) and human/host genetic variability (Proudnikov et al. 2012), pharmacokinetics (Kuhlman et al. 1996; Eap et al. 2002; Elkader and Sproule 2005; Kharasch 2017; Kringen et al. 2017), and sex (Zubieta et al. 2002; Taylor and Davies 2010; Venuto et al. 2014; Marinho et al. 2019) all contribute to variability in responsiveness. The following subsections will focus on key factors affecting opioid and HIV comorbidity."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T781","span":{"begin":78,"end":79},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T782","span":{"begin":204,"end":209},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T783","span":{"begin":555,"end":560},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"}],"text":"The interplay of complex host and viral genetic differences is likely to play a huge role in determining pathologic outcomes in PWH. For example, differences in HIV strains/variants (Rao et al. 2013) and human/host genetic variability (Proudnikov et al. 2012), pharmacokinetics (Kuhlman et al. 1996; Eap et al. 2002; Elkader and Sproule 2005; Kharasch 2017; Kringen et al. 2017), and sex (Zubieta et al. 2002; Taylor and Davies 2010; Venuto et al. 2014; Marinho et al. 2019) all contribute to variability in responsiveness. The following subsections will focus on key factors affecting opioid and HIV comorbidity."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2509","span":{"begin":300,"end":303},"obj":"Gene"},{"id":"2510","span":{"begin":183,"end":186},"obj":"Gene"},{"id":"2511","span":{"begin":204,"end":209},"obj":"Species"},{"id":"2512","span":{"begin":161,"end":164},"obj":"Species"},{"id":"2513","span":{"begin":597,"end":600},"obj":"Species"}],"attributes":[{"id":"A2509","pred":"tao:has_database_id","subj":"2509","obj":"Gene:2028"},{"id":"A2510","pred":"tao:has_database_id","subj":"2510","obj":"Gene:314"},{"id":"A2511","pred":"tao:has_database_id","subj":"2511","obj":"Tax:9606"},{"id":"A2512","pred":"tao:has_database_id","subj":"2512","obj":"Tax:12721"},{"id":"A2513","pred":"tao:has_database_id","subj":"2513","obj":"Tax:12721"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The interplay of complex host and viral genetic differences is likely to play a huge role in determining pathologic outcomes in PWH. For example, differences in HIV strains/variants (Rao et al. 2013) and human/host genetic variability (Proudnikov et al. 2012), pharmacokinetics (Kuhlman et al. 1996; Eap et al. 2002; Elkader and Sproule 2005; Kharasch 2017; Kringen et al. 2017), and sex (Zubieta et al. 2002; Taylor and Davies 2010; Venuto et al. 2014; Marinho et al. 2019) all contribute to variability in responsiveness. The following subsections will focus on key factors affecting opioid and HIV comorbidity."}

{"project":"LitCovid-sentences","denotations":[{"id":"T992","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"T993","span":{"begin":133,"end":193},"obj":"Sentence"},{"id":"T994","span":{"begin":194,"end":253},"obj":"Sentence"},{"id":"T995","span":{"begin":254,"end":293},"obj":"Sentence"},{"id":"T996","span":{"begin":294,"end":310},"obj":"Sentence"},{"id":"T997","span":{"begin":311,"end":372},"obj":"Sentence"},{"id":"T998","span":{"begin":373,"end":403},"obj":"Sentence"},{"id":"T999","span":{"begin":404,"end":447},"obj":"Sentence"},{"id":"T1000","span":{"begin":448,"end":468},"obj":"Sentence"},{"id":"T1001","span":{"begin":469,"end":523},"obj":"Sentence"},{"id":"T1002","span":{"begin":524,"end":613},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The interplay of complex host and viral genetic differences is likely to play a huge role in determining pathologic outcomes in PWH. For example, differences in HIV strains/variants (Rao et al. 2013) and human/host genetic variability (Proudnikov et al. 2012), pharmacokinetics (Kuhlman et al. 1996; Eap et al. 2002; Elkader and Sproule 2005; Kharasch 2017; Kringen et al. 2017), and sex (Zubieta et al. 2002; Taylor and Davies 2010; Venuto et al. 2014; Marinho et al. 2019) all contribute to variability in responsiveness. The following subsections will focus on key factors affecting opioid and HIV comorbidity."}

{"project":"2_test","denotations":[{"id":"32876803-23758766-62958219","span":{"begin":194,"end":198},"obj":"23758766"},{"id":"32876803-22457278-62958220","span":{"begin":254,"end":258},"obj":"22457278"},{"id":"32876803-8889672-62958221","span":{"begin":294,"end":298},"obj":"8889672"},{"id":"32876803-12405865-62958222","span":{"begin":311,"end":315},"obj":"12405865"},{"id":"32876803-15966752-62958223","span":{"begin":337,"end":341},"obj":"15966752"},{"id":"32876803-28263461-62958224","span":{"begin":352,"end":356},"obj":"28263461"},{"id":"32876803-28723731-62958225","span":{"begin":373,"end":377},"obj":"28723731"},{"id":"32876803-12077205-62958226","span":{"begin":404,"end":408},"obj":"12077205"},{"id":"32876803-20543610-62958227","span":{"begin":428,"end":432},"obj":"20543610"},{"id":"32876803-25159623-62958228","span":{"begin":448,"end":452},"obj":"25159623"},{"id":"32876803-30712401-62958229","span":{"begin":469,"end":473},"obj":"30712401"}],"text":"The interplay of complex host and viral genetic differences is likely to play a huge role in determining pathologic outcomes in PWH. For example, differences in HIV strains/variants (Rao et al. 2013) and human/host genetic variability (Proudnikov et al. 2012), pharmacokinetics (Kuhlman et al. 1996; Eap et al. 2002; Elkader and Sproule 2005; Kharasch 2017; Kringen et al. 2017), and sex (Zubieta et al. 2002; Taylor and Davies 2010; Venuto et al. 2014; Marinho et al. 2019) all contribute to variability in responsiveness. The following subsections will focus on key factors affecting opioid and HIV comorbidity."}