PMC:7463108 / 67505-68675 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"Even though neural progenitors (Krathwohl and Kaiser 2004; Lawrence et al. 2004; Rothenaigner et al. 2007; Schwartz et al. 2007; Balinang et al. 2017), neuroblast cell lines (Ensoli et al. 1994; Rothenaigner et al. 2007), and/or immature astroglia (Atwood et al. 1993; Tornatore et al. 1994; Barat et al. 2018) can harbor HIV infection (reviewed by Hauser and Knapp 2014; Putatunda et al. 2019), the degree to which they are a source of active infection or serve as a latent viral reservoir (Blankson et al. 2002; Bruner et al. 2019) by retaining intact proviral DNA within incipient macroglial progeny is uncertain. In fact, spurious reports of HIV-infected adult neurons (Torres-Munoz et al. 2001; Canto-Nogues et al. 2005) may result from the retention of proviral genes that integrated into pluripotent neural progenitors or neuroblasts at earlier stages during maturation. Importantly, prolonged exposure to opioids can increase the production of HIV in human neural progenitor cells (hNPCs). Exposure of R5-tropic HIVBaL-infected hNPCs to morphine continuously for 21 d increased viral production compared to HIVBaL infection alone in vitro (Balinang et al. 2017).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T656","span":{"begin":152,"end":162},"obj":"Body_part"},{"id":"T657","span":{"begin":163,"end":167},"obj":"Body_part"},{"id":"T658","span":{"begin":322,"end":325},"obj":"Body_part"},{"id":"T659","span":{"begin":563,"end":566},"obj":"Body_part"},{"id":"T660","span":{"begin":646,"end":649},"obj":"Body_part"},{"id":"T661","span":{"begin":665,"end":672},"obj":"Body_part"},{"id":"T662","span":{"begin":829,"end":840},"obj":"Body_part"},{"id":"T663","span":{"begin":952,"end":955},"obj":"Body_part"},{"id":"T664","span":{"begin":983,"end":988},"obj":"Body_part"}],"attributes":[{"id":"A656","pred":"fma_id","subj":"T656","obj":"http://purl.org/sig/ont/fma/fma70563"},{"id":"A657","pred":"fma_id","subj":"T657","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A658","pred":"fma_id","subj":"T658","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A659","pred":"fma_id","subj":"T659","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A660","pred":"fma_id","subj":"T660","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A661","pred":"fma_id","subj":"T661","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A662","pred":"fma_id","subj":"T662","obj":"http://purl.org/sig/ont/fma/fma70563"},{"id":"A663","pred":"fma_id","subj":"T663","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A664","pred":"fma_id","subj":"T664","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T656","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T657","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T658","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T659","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T660","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T661","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T662","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T663","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T664","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T161","span":{"begin":322,"end":335},"obj":"Disease"},{"id":"T162","span":{"begin":326,"end":335},"obj":"Disease"},{"id":"T163","span":{"begin":444,"end":453},"obj":"Disease"},{"id":"T164","span":{"begin":1010,"end":1012},"obj":"Disease"},{"id":"T165","span":{"begin":1122,"end":1131},"obj":"Disease"}],"attributes":[{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0005109"},{"id":"A162","pred":"mondo_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A163","pred":"mondo_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A164","pred":"mondo_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/MONDO_0016654"},{"id":"A165","pred":"mondo_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T735","span":{"begin":152,"end":162},"obj":"http://purl.obolibrary.org/obo/CL_0000031"},{"id":"T736","span":{"begin":163,"end":173},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T737","span":{"begin":305,"end":309},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T738","span":{"begin":425,"end":426},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T739","span":{"begin":437,"end":443},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T740","span":{"begin":466,"end":467},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T741","span":{"begin":768,"end":773},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T742","span":{"begin":829,"end":843},"obj":"http://purl.obolibrary.org/obo/CL_0000031"},{"id":"T743","span":{"begin":959,"end":964},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T744","span":{"begin":983,"end":988},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T735","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T736","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T737","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T738","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T739","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T740","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T741","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T742","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T743","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T744","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T40596","span":{"begin":563,"end":566},"obj":"Chemical"},{"id":"T216","span":{"begin":1045,"end":1053},"obj":"Chemical"}],"attributes":[{"id":"A28135","pred":"chebi_id","subj":"T40596","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A80787","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A44519","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"subj":"T40596","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2388","span":{"begin":959,"end":964},"obj":"Species"},{"id":"2389","span":{"begin":952,"end":955},"obj":"Species"},{"id":"2390","span":{"begin":1045,"end":1053},"obj":"Chemical"},{"id":"2391","span":{"begin":315,"end":335},"obj":"Disease"},{"id":"2392","span":{"begin":444,"end":453},"obj":"Disease"},{"id":"2393","span":{"begin":646,"end":658},"obj":"Disease"},{"id":"2394","span":{"begin":1020,"end":1041},"obj":"Disease"},{"id":"2395","span":{"begin":1115,"end":1131},"obj":"Disease"}],"attributes":[{"id":"A2388","pred":"tao:has_database_id","subj":"2388","obj":"Tax:9606"},{"id":"A2389","pred":"tao:has_database_id","subj":"2389","obj":"Tax:12721"},{"id":"A2390","pred":"tao:has_database_id","subj":"2390","obj":"MESH:D009020"},{"id":"A2391","pred":"tao:has_database_id","subj":"2391","obj":"MESH:D015658"},{"id":"A2392","pred":"tao:has_database_id","subj":"2392","obj":"MESH:D007239"},{"id":"A2393","pred":"tao:has_database_id","subj":"2393","obj":"MESH:D015658"},{"id":"A2394","pred":"tao:has_database_id","subj":"2394","obj":"MESH:D007239"},{"id":"A2395","pred":"tao:has_database_id","subj":"2395","obj":"MESH:D007239"},{"subj":"2388","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2389","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2390","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2391","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2392","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2393","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2394","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2395","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T129","span":{"begin":746,"end":755},"obj":"http://purl.obolibrary.org/obo/GO_0051235"}],"attributes":[{"subj":"T129","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T931","span":{"begin":0,"end":74},"obj":"Sentence"},{"id":"T932","span":{"begin":75,"end":100},"obj":"Sentence"},{"id":"T933","span":{"begin":101,"end":122},"obj":"Sentence"},{"id":"T934","span":{"begin":123,"end":144},"obj":"Sentence"},{"id":"T935","span":{"begin":145,"end":188},"obj":"Sentence"},{"id":"T936","span":{"begin":189,"end":214},"obj":"Sentence"},{"id":"T937","span":{"begin":215,"end":262},"obj":"Sentence"},{"id":"T938","span":{"begin":263,"end":285},"obj":"Sentence"},{"id":"T939","span":{"begin":286,"end":304},"obj":"Sentence"},{"id":"T940","span":{"begin":305,"end":388},"obj":"Sentence"},{"id":"T941","span":{"begin":389,"end":507},"obj":"Sentence"},{"id":"T942","span":{"begin":508,"end":527},"obj":"Sentence"},{"id":"T943","span":{"begin":528,"end":616},"obj":"Sentence"},{"id":"T944","span":{"begin":617,"end":693},"obj":"Sentence"},{"id":"T945","span":{"begin":694,"end":719},"obj":"Sentence"},{"id":"T946","span":{"begin":720,"end":877},"obj":"Sentence"},{"id":"T947","span":{"begin":878,"end":997},"obj":"Sentence"},{"id":"T948","span":{"begin":998,"end":1163},"obj":"Sentence"},{"id":"T949","span":{"begin":1164,"end":1170},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T931","pred":"source","obj":"LitCovid-sentences"},{"subj":"T932","pred":"source","obj":"LitCovid-sentences"},{"subj":"T933","pred":"source","obj":"LitCovid-sentences"},{"subj":"T934","pred":"source","obj":"LitCovid-sentences"},{"subj":"T935","pred":"source","obj":"LitCovid-sentences"},{"subj":"T936","pred":"source","obj":"LitCovid-sentences"},{"subj":"T937","pred":"source","obj":"LitCovid-sentences"},{"subj":"T938","pred":"source","obj":"LitCovid-sentences"},{"subj":"T939","pred":"source","obj":"LitCovid-sentences"},{"subj":"T940","pred":"source","obj":"LitCovid-sentences"},{"subj":"T941","pred":"source","obj":"LitCovid-sentences"},{"subj":"T942","pred":"source","obj":"LitCovid-sentences"},{"subj":"T943","pred":"source","obj":"LitCovid-sentences"},{"subj":"T944","pred":"source","obj":"LitCovid-sentences"},{"subj":"T945","pred":"source","obj":"LitCovid-sentences"},{"subj":"T946","pred":"source","obj":"LitCovid-sentences"},{"subj":"T947","pred":"source","obj":"LitCovid-sentences"},{"subj":"T948","pred":"source","obj":"LitCovid-sentences"},{"subj":"T949","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32876803-18090275-62958187","span":{"begin":101,"end":105},"obj":"18090275"},{"id":"32876803-28099189-62958188","span":{"begin":145,"end":149},"obj":"28099189"},{"id":"32876803-8178451-62958189","span":{"begin":189,"end":193},"obj":"8178451"},{"id":"32876803-18090275-62958190","span":{"begin":215,"end":219},"obj":"18090275"},{"id":"32876803-8267293-62958191","span":{"begin":263,"end":267},"obj":"8267293"},{"id":"32876803-8254781-62958192","span":{"begin":286,"end":290},"obj":"8254781"},{"id":"32876803-29464785-62958193","span":{"begin":305,"end":309},"obj":"29464785"},{"id":"32876803-25175867-62958194","span":{"begin":366,"end":370},"obj":"25175867"},{"id":"32876803-30899112-62958195","span":{"begin":389,"end":393},"obj":"30899112"},{"id":"32876803-11818490-62958196","span":{"begin":508,"end":512},"obj":"11818490"},{"id":"32876803-30700913-62958197","span":{"begin":528,"end":532},"obj":"30700913"},{"id":"32876803-11556545-62958198","span":{"begin":694,"end":698},"obj":"11556545"},{"id":"32876803-16055948-62958199","span":{"begin":720,"end":724},"obj":"16055948"},{"id":"32876803-28099189-62958200","span":{"begin":1164,"end":1168},"obj":"28099189"}],"attributes":[{"subj":"32876803-18090275-62958187","pred":"source","obj":"2_test"},{"subj":"32876803-28099189-62958188","pred":"source","obj":"2_test"},{"subj":"32876803-8178451-62958189","pred":"source","obj":"2_test"},{"subj":"32876803-18090275-62958190","pred":"source","obj":"2_test"},{"subj":"32876803-8267293-62958191","pred":"source","obj":"2_test"},{"subj":"32876803-8254781-62958192","pred":"source","obj":"2_test"},{"subj":"32876803-29464785-62958193","pred":"source","obj":"2_test"},{"subj":"32876803-25175867-62958194","pred":"source","obj":"2_test"},{"subj":"32876803-30899112-62958195","pred":"source","obj":"2_test"},{"subj":"32876803-11818490-62958196","pred":"source","obj":"2_test"},{"subj":"32876803-30700913-62958197","pred":"source","obj":"2_test"},{"subj":"32876803-11556545-62958198","pred":"source","obj":"2_test"},{"subj":"32876803-16055948-62958199","pred":"source","obj":"2_test"},{"subj":"32876803-28099189-62958200","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d7ec93","default":true},{"id":"LitCovid-PD-MONDO","color":"#e793ec"},{"id":"LitCovid-PD-CLO","color":"#93eccd"},{"id":"LitCovid-PD-CHEBI","color":"#ecb393"},{"id":"LitCovid-PubTator","color":"#9993ec"},{"id":"LitCovid-PD-GO-BP","color":"#a6ec93"},{"id":"LitCovid-sentences","color":"#ec93c0"},{"id":"2_test","color":"#93daec"}]}]}}