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PMC:7463108 / 63836-65154 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T637 0-3 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T638 110-113 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T639 203-206 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T640 260-272 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T641 435-440 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T642 649-652 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T643 778-791 Body_part denotes aspartic acid http://purl.org/sig/ont/fma/fma82760
T644 1249-1259 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T645 1270-1277 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T155 260-272 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T152 97-106 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T153 203-216 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T154 207-216 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T722 74-77 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T723 236-237 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T724 435-440 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T725 890-898 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T726 1196-1205 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T89434 391-397 Chemical denotes toxins http://purl.obolibrary.org/obo/CHEBI_27026
T81711 709-714 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T67267 717-724 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T72419 727-733 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T15567 755-759 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T21808 761-765 Chemical denotes AMPA http://purl.obolibrary.org/obo/CHEBI_28812
T45000 767-791 Chemical denotes N-methyl-D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_31882
T26423 769-775 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T62952 776-791 Chemical denotes D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_17364
T40246 778-791 Chemical denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T198 787-791 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T34192 793-797 Chemical denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T34723 1270-1277 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45427 1285-1287 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2293 74-77 Gene denotes CD4 Gene:920
2294 655-658 Gene denotes Tat Gene:6898
2295 884-889 Gene denotes Kv1.3 Gene:3738
2296 1122-1125 Gene denotes Tat Gene:6898
2297 1158-1161 Gene denotes Tat Gene:6898
2298 1189-1195 Gene denotes GSK-3β Gene:2931
2299 400-404 Gene denotes Nath Gene:80155
2300 962-965 Gene denotes Tat Gene:6898
2301 649-654 Species denotes HIV-1 Tax:11676
2302 0-3 Species denotes HIV Tax:12721
2303 110-113 Species denotes HIV Tax:12721
2304 365-375 Chemical denotes virotoxins MESH:C026460
2305 707-759 Chemical denotes α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid MESH:D018350
2306 761-765 Chemical denotes AMPA MESH:D018350
2307 767-791 Chemical denotes N-methyl-D-aspartic acid MESH:D016202
2308 793-797 Chemical denotes NMDA MESH:D016202
2309 97-106 Disease denotes infection MESH:D007239
2310 128-133 Disease denotes Esiri
2311 203-216 Disease denotes HIV infection MESH:D015658
2312 260-279 Disease denotes white matter damage MESH:D056784
2313 414-422 Disease denotes infected MESH:D007239
2314 548-552 Disease denotes ARVs
2315 572-587 Disease denotes OL cytotoxicity MESH:D064420

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T122 792-807 http://purl.obolibrary.org/obo/GO_0004972 denotes (NMDA) receptor
T123 1196-1205 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T124 1291-1297 http://purl.obolibrary.org/obo/GO_0004683 denotes CaMKII

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T868 0-64 Sentence denotes HIV likely damages OLs through both direct and indirect actions.
T869 65-140 Sentence denotes OLs lack CD4, and reports of OL infection by HIV are variable (Esiri et al.
T870 141-162 Sentence denotes 1991; Albright et al.
T871 163-189 Sentence denotes 1996; Wohlschlaeger et al.
T872 190-298 Sentence denotes 2009); thus, HIV infection of OLs is unlikely a major avenue of OL or white matter damage (discussed below).
T873 299-486 Sentence denotes Alternatively, bystander damage to OLs through the production of “virotoxins” and “cellular toxins” (Nath 1999) by infected neighboring cells is more likely to be operative (Hauser et al.
T874 487-503 Sentence denotes 2009; Zou et al.
T875 504-523 Sentence denotes 2015; Jensen et al.
T876 524-540 Sentence denotes 2019; Zou et al.
T877 541-547 Sentence denotes 2019).
T878 548-602 Sentence denotes ARVs also contribute to OL cytotoxicity (Jensen et al.
T879 603-621 Sentence denotes 2015; Festa et al.
T880 622-641 Sentence denotes 2019; Jensen et al.
T881 642-648 Sentence denotes 2019).
T882 649-840 Sentence denotes HIV-1 Tat directly induces damage in isolated OLs through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/N-methyl-D-aspartic acid (NMDA) receptor-dependent mechanisms (Zou et al.
T883 841-910 Sentence denotes 2015) and is also associated with abnormal Kv1.3 activity (Liu et al.
T884 911-917 Sentence denotes 2017).
T885 918-1014 Sentence denotes Immature OLs are preferentially targeted by Tat compared to differentiated OLs (Khurdayan et al.
T886 1015-1032 Sentence denotes 2004; Hahn et al.
T887 1033-1049 Sentence denotes 2012; Zou et al.
T888 1050-1062 Sentence denotes 2015, 2019).
T889 1063-1311 Sentence denotes While the reasons why immature OLs are more susceptible to Tat are unclear, unlike mature OLs, Tat preferentially upregulates GSK-3β signaling in undifferentiated OLs by inhibiting Ca2+/calmodulin-dependent protein kinase II β (CaMKIIβ) (Zou et al.
T890 1312-1318 Sentence denotes 2019).

2_test

Id Subject Object Predicate Lexical cue
32876803-1657038-62958150 141-145 1657038 denotes 1991
32876803-8599205-62958151 163-167 8599205 denotes 1996
32876803-19185416-62958152 190-194 19185416 denotes 2009
32876803-10718533-62958153 405-409 10718533 denotes 1999
32876803-18756534-62958154 487-491 18756534 denotes 2009
32876803-31442414-62958155 524-528 31442414 denotes 2019
32876803-26469251-62958156 603-607 26469251 denotes 2015
32876803-31442414-62958157 642-646 31442414 denotes 2019
32876803-22865725-62958158 1033-1037 22865725 denotes 2012