PMC:7463108 / 61446-62474
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T612 | 32-37 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T613 | 38-43 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T614 | 161-176 | Body_part | denotes | tight junctions | http://purl.org/sig/ont/fma/fma67397 |
| T615 | 305-310 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T616 | 388-400 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T617 | 446-451 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T618 | 505-510 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T619 | 530-533 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T620 | 619-633 | Body_part | denotes | tight junction | http://purl.org/sig/ont/fma/fma67397 |
| T621 | 634-642 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T622 | 700-705 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T623 | 809-815 | Body_part | denotes | breast | http://purl.org/sig/ont/fma/fma9601 |
| T624 | 834-841 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T625 | 878-883 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T626 | 1001-1004 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T142 | 32-51 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T143 | 32-37 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T144 | 38-43 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T145 | 305-310 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T146 | 446-451 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T147 | 505-510 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T148 | 700-705 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T149 | 809-815 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T150 | 878-883 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T144 | 809-822 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T145 | 816-822 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T695 | 32-37 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T696 | 32-37 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T697 | 38-43 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T698 | 38-43 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T699 | 167-176 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junctions |
| T700 | 305-310 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T701 | 305-310 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T702 | 335-336 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T703 | 446-451 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T704 | 446-451 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T705 | 505-510 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T706 | 505-510 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T707 | 600-601 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T708 | 625-633 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junction |
| T709 | 700-705 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T710 | 700-705 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T711 | 809-815 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T712 | 878-883 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T713 | 878-883 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T6618 | 388-400 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T70131 | 634-642 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T182 | 834-841 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T37664 | 899-904 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T184 | 931-936 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2217 | 386-400 | Gene | denotes | P-glycoprotein | Gene:5243 |
| 2218 | 402-406 | Gene | denotes | P-gp | Gene:5243 |
| 2219 | 788-792 | Gene | denotes | P-gp | Gene:5243 |
| 2220 | 809-841 | Gene | denotes | breast cancer resistance protein | Gene:9429 |
| 2221 | 843-847 | Gene | denotes | Bcrp | Gene:9429 |
| 2222 | 530-533 | Species | denotes | HIV | Tax:12721 |
| 2223 | 1001-1004 | Species | denotes | HIV | Tax:12721 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T112 | 357-363 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
| T113 | 357-363 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
| T114 | 386-400 | http://purl.obolibrary.org/obo/GO_0008559 | denotes | P-glycoprotein |
| T115 | 415-423 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | effluxes |
| T116 | 415-423 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | effluxes |
| T117 | 602-611 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | breakdown |
| T118 | 747-753 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
| T119 | 747-753 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
| T120 | 754-765 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporter |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T830 | 100-311 | Sentence | denotes | Under normal conditions (represented above the dotted line), tight junctions are intact which restricts the leakage of paracellular, typically small hydrophilic, compounds, across the barrier and into the brain. |
| T831 | 312-511 | Sentence | denotes | Additionally, there is a basal expression of efflux transporters, such as P-glycoprotein (P-gp), which effluxes substrates out of the brain, serving to restrict overall accumulation within the brain. |
| T832 | 512-706 | Sentence | denotes | In the setting of HIV and opiate exposure (represented below the dotted line), there is a breakdown of the tight junction proteins and increased leakage of paracellular compounds into the brain. |
| T833 | 707-1028 | Sentence | denotes | Additionally, opiate exposure increases efflux transporter expression, including P-gp and potentially breast cancer resistance protein (Bcrp), thereby restricting overall brain penetration of drugs (like many antiretroviral drugs) which are substrates for these transporters and in response to HIV and/or opioid exposure. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T49 | 809-822 | Phenotype | denotes | breast cancer | http://purl.obolibrary.org/obo/HP_0003002 |