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PMC:7463108 / 60777-62474 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T599 32-35 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T600 90-95 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T601 155-169 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T602 170-178 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T603 211-219 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T604 273-278 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T605 293-301 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T606 343-348 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T607 420-423 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T608 468-476 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T609 488-493 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T610 601-604 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T611 626-631 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T612 701-706 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T613 707-712 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T614 830-845 Body_part denotes tight junctions http://purl.org/sig/ont/fma/fma67397
T615 974-979 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T616 1057-1069 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T617 1115-1120 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T618 1174-1179 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T619 1199-1202 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T620 1288-1302 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T621 1303-1311 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T622 1369-1374 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T623 1478-1484 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T624 1503-1510 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T625 1547-1552 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T626 1670-1673 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T136 90-95 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T137 273-278 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T138 343-348 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T139 420-423 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T140 488-493 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T141 626-631 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T142 701-720 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T143 701-706 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T144 707-712 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T145 974-979 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T146 1115-1120 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T147 1174-1179 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T148 1369-1374 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T149 1478-1484 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T150 1547-1552 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T141 302-305 Disease denotes MDM http://purl.obolibrary.org/obo/MONDO_0009552
T142 601-614 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T143 605-614 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T144 1478-1491 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T145 1485-1491 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T680 90-95 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T681 90-95 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T682 161-169 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T683 273-278 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T684 273-278 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T685 293-301 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T686 343-348 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T687 343-348 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T688 420-423 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T689 420-423 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T690 420-423 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T691 488-493 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T692 488-493 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T693 626-631 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T694 626-631 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T695 701-706 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T696 701-706 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T697 707-712 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T698 707-712 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T699 836-845 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctions
T700 974-979 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T701 974-979 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T702 1004-1005 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T703 1115-1120 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T704 1115-1120 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T705 1174-1179 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T706 1174-1179 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T707 1269-1270 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T708 1294-1302 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T709 1369-1374 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T710 1369-1374 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T711 1478-1484 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T712 1547-1552 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T713 1547-1552 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T20102 170-178 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T81863 211-219 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T957 254-263 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T7188 453-457 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T43871 468-476 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T179 534-538 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T6618 1057-1069 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T70131 1303-1311 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T182 1503-1510 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37664 1568-1573 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T184 1600-1605 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2217 1055-1069 Gene denotes P-glycoprotein Gene:5243
2218 1071-1075 Gene denotes P-gp Gene:5243
2219 1457-1461 Gene denotes P-gp Gene:5243
2220 1478-1510 Gene denotes breast cancer resistance protein Gene:9429
2221 1512-1516 Gene denotes Bcrp Gene:9429
2222 1199-1202 Species denotes HIV Tax:12721
2223 1670-1673 Species denotes HIV Tax:12721
2228 302-305 Gene denotes MDM Gene:57152
2229 32-35 Species denotes HIV Tax:12721
2230 359-367 Disease denotes infected MESH:D007239
2231 601-614 Disease denotes HIV infection MESH:D015658

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T108 67-78 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T109 97-106 http://purl.obolibrary.org/obo/GO_0009056 denotes Breakdown
T110 453-467 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T111 458-467 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T112 1026-1032 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T113 1026-1032 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T114 1055-1069 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T115 1084-1092 http://purl.obolibrary.org/obo/GO_0140352 denotes effluxes
T116 1084-1092 http://purl.obolibrary.org/obo/GO_0140115 denotes effluxes
T117 1271-1280 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T118 1416-1422 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T119 1416-1422 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T120 1423-1434 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T825 0-96 Sentence denotes Taken together, BBB damage from HIV and/or opiates can disrupt the homeostasis within the brain.
T826 97-424 Sentence denotes Breakdown of paracellular processes, through decreases in tight junction proteins and increased cellular adhesion proteins, increased leakage of circulating molecules into the brain and increased monocyte/MDM adhesion and transmigration into the brain, which if infected, can serve to replenish viral reservoirs within the CNS.
T827 425-554 Sentence denotes Furthermore, alterations in drug transport proteins within the brain can decrease ARV efficacy by decreasing drug concentrations.
T828 555-661 Sentence denotes Collectively, these changes serve to maintain HIV infection within the brain (see Fig. 4; Tables 1 and 2).
T829 662-768 Sentence denotes Fig. 4 Schematic representation of the blood-brain barrier and other components of the neurovascular unit.
T830 769-980 Sentence denotes Under normal conditions (represented above the dotted line), tight junctions are intact which restricts the leakage of paracellular, typically small hydrophilic, compounds, across the barrier and into the brain.
T831 981-1180 Sentence denotes Additionally, there is a basal expression of efflux transporters, such as P-glycoprotein (P-gp), which effluxes substrates out of the brain, serving to restrict overall accumulation within the brain.
T832 1181-1375 Sentence denotes In the setting of HIV and opiate exposure (represented below the dotted line), there is a breakdown of the tight junction proteins and increased leakage of paracellular compounds into the brain.
T833 1376-1697 Sentence denotes Additionally, opiate exposure increases efflux transporter expression, including P-gp and potentially breast cancer resistance protein (Bcrp), thereby restricting overall brain penetration of drugs (like many antiretroviral drugs) which are substrates for these transporters and in response to HIV and/or opioid exposure.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T49 1478-1491 Phenotype denotes breast cancer http://purl.obolibrary.org/obo/HP_0003002