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PMC:7463108 / 59485-60776 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T581 0-3 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T582 5-8 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T583 17-25 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T584 111-119 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T585 128-139 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T586 156-161 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T587 204-215 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T588 225-230 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T589 365-368 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T590 390-398 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T591 430-433 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T592 673-676 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T593 709-712 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T594 735-745 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T595 996-1004 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T596 1050-1060 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T597 1209-1213 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T598 1235-1240 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T132 156-161 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T133 225-230 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T134 430-433 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T135 1235-1240 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T139 291-308 Disease denotes neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T140 1124-1134 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T664 111-119 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T665 156-161 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T666 156-161 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T667 225-230 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T668 225-230 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T669 390-398 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T670 430-433 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T671 430-433 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T672 430-433 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T673 735-745 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T674 974-975 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T675 996-1004 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T676 1209-1213 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T677 1235-1240 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T678 1235-1240 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T679 1256-1260 http://purl.obolibrary.org/obo/CLO_0050768 denotes TLR2

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T26139 17-25 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T163 378-386 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T58500 694-696 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T54779 723-731 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T168 922-924 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T7125 945-953 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T51995 957-970 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T172 1150-1158 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2183 370-373 Gene denotes Tat Gene:6898
2184 677-680 Gene denotes Tat Gene:6898
2185 715-718 Gene denotes Tat Gene:6898
2186 802-806 Gene denotes CCL2 Gene:6347
2187 811-815 Gene denotes CCL5 Gene:6352
2188 885-888 Gene denotes MOR Gene:4988
2189 937-940 Gene denotes Tat Gene:6898
2190 1035-1039 Gene denotes CCL5 Gene:6352
2191 1166-1169 Gene denotes Tat Gene:234724
2192 1256-1260 Gene denotes TLR2 Gene:24088
2193 1265-1269 Gene denotes TLR4 Gene:21898
2194 902-906 Gene denotes Hage Gene:55510
2195 709-714 Species denotes HIV-1 Tax:11676
2196 1121-1134 Species denotes S. pneumoniae Tax:1313
2197 1144-1148 Species denotes mice Tax:10090
2198 0-3 Species denotes HIV Tax:12721
2199 365-368 Species denotes HIV Tax:12721
2200 673-676 Species denotes HIV Tax:12721
2201 378-386 Chemical denotes morphine MESH:D009020
2202 723-731 Chemical denotes morphine MESH:D009020
2203 945-953 Chemical denotes morphine MESH:D009020
2204 957-970 Chemical denotes buprenorphine MESH:D002047
2205 1150-1158 Chemical denotes morphine MESH:D009020
2206 5-25 Disease denotes HIV-1 viral proteins
2207 194-202 Disease denotes infected MESH:D007239
2209 1135-1143 Disease denotes infected MESH:D007239

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T107 1202-1225 http://purl.obolibrary.org/obo/GO_0050900 denotes immune cell trafficking

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T806 0-162 Sentence denotes HIV, HIV-1 viral proteins, and opiate-induced barrier dysfunction is associated with increased infiltration of monocyte-derived macrophages (MDMs) into the brain.
T807 163-309 Sentence denotes Enhanced influx of peripheral (infected) macrophages into the brain can serve to replenish viral reservoirs and further promote neuroinflammation.
T808 310-448 Sentence denotes Several studies have examined the individual impact of HIV, Tat, or morphine on monocyte adhesion or migration into the CNS (Nottet et al.
T809 449-464 Sentence denotes 1996; Wu et al.
T810 465-491 Sentence denotes 2000; Fischer-Smith et al.
T811 492-510 Sentence denotes 2001; Pello et al.
T812 511-532 Sentence denotes 2006; Williams et al.
T813 533-560 Sentence denotes 2013a, 2014; Strazza et al.
T814 561-582 Sentence denotes 2016; Leibrand et al.
T815 583-604 Sentence denotes 2017; Chilunda et al.
T816 605-611 Sentence denotes 2019).
T817 612-693 Sentence denotes However, fewer studies have examined the combined effects of HIV/Tat and opiates.
T818 694-852 Sentence denotes Co-exposure of HIV-1 Tat and morphine on astrocytes increases the production of chemoattractants, primarily CCL2 and CCL5, and increases microglial migration.
T819 853-913 Sentence denotes These effects were inhibited by MOR blockade (El-Hage et al.
T820 914-921 Sentence denotes 2006b).
T821 922-1076 Sentence denotes Co-exposure of Tat and morphine or buprenorphine to a BBB model increases monocyte transmigration in response to CCL5 and other chemokines (Mahajan et al.
T822 1077-1110 Sentence denotes 2008; Jaureguiberry-Bravo et. al.
T823 1111-1117 Sentence denotes 2016).
T824 1118-1291 Sentence denotes In S. pneumoniae-infected mice, morphine and/or Tat exposure significantly enhances immune cell trafficking into the brain via actions at TLR2 and TLR4 (Dutta and Roy 2015).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T48 1124-1134 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32876803-8558009-62958123 449-453 8558009 denotes 1996
32876803-24862333-62958125 540-544 24862333 denotes 2014
32876803-28057474-62958126 583-587 28057474 denotes 2017
32876803-31473221-62958127 605-609 31473221 denotes 2019
32876803-27009099-62958128 1111-1115 27009099 denotes 2016