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PMC:7463108 / 53449-55481 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T523 44-47 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T524 89-92 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T525 149-154 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T526 155-160 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T527 232-235 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T528 334-337 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T529 339-342 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T530 363-366 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T531 367-375 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T532 409-423 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T533 424-432 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T534 869-886 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T535 881-886 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T536 1059-1073 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T537 1074-1082 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T538 1471-1479 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T539 1491-1503 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T540 1925-1933 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T100 149-168 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T101 149-154 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T102 155-160 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T103 232-235 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T104 334-337 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T611 149-154 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T612 149-154 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T613 155-160 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T614 155-160 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T615 232-235 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T616 232-235 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T617 232-235 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T618 334-337 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T619 334-337 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T620 334-337 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T621 415-423 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T622 869-886 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T623 1065-1073 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T77 311-315 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T66460 367-375 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T79 424-432 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T80 1074-1082 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T11026 1227-1235 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T36538 1278-1286 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T51283 1401-1409 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T26096 1459-1463 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T88 1471-1479 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T30663 1491-1503 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T56470 1536-1544 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T4369 1833-1841 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T5483 1910-1914 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T96748 1925-1933 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T82380 2000-2005 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1983 1489-1503 Gene denotes P-glycoprotein Gene:5243
1984 1505-1509 Gene denotes P-gp Gene:5243
1985 1578-1582 Gene denotes P-gp Gene:5243
1986 1754-1758 Gene denotes P-gp Gene:5243
1987 44-47 Species denotes HIV Tax:12721
1988 89-92 Species denotes HIV Tax:12721
1989 339-342 Species denotes HIV Tax:12721
1990 1227-1235 Chemical denotes morphine MESH:D009020
1991 1278-1286 Chemical denotes morphine MESH:D009020
1992 1401-1409 Chemical denotes morphine MESH:D009020
1993 1536-1544 Chemical denotes morphine MESH:D009020
1994 1833-1841 Chemical denotes morphine MESH:D009020
1995 363-375 Disease denotes HIV proteins MESH:D015658

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T94 236-247 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T95 380-389 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T96 1464-1470 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T97 1464-1470 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T98 1489-1503 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T99 1910-1924 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T100 1915-1924 http://purl.obolibrary.org/obo/GO_0006810 denotes transport

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T744 0-175 Sentence denotes Despite growing evidence on how opiates and HIV interact to impact the neuropathology of HIV, little is known about their interactive effects on the blood-brain barrier (BBB).
T745 176-338 Sentence denotes BBB integrity and function are critical for maintaining CNS homeostasis, and mediating neuroimmune interactions with the periphery and drug delivery into the CNS.
T746 339-449 Sentence denotes HIV and many individual HIV proteins can breakdown the BBB disrupting tight junction proteins (Dallasta et al.
T747 450-468 Sentence denotes 1999; Boven et al.
T748 469-488 Sentence denotes 2000; Andras et al.
T749 489-509 Sentence denotes 2003; Mahajan et al.
T750 510-531 Sentence denotes 2008; Banerjee et al.
T751 532-551 Sentence denotes 2010; Gandhi et al.
T752 552-567 Sentence denotes 2010; Xu et al.
T753 568-586 Sentence denotes 2012; Patel et al.
T754 587-712 Sentence denotes 2017) and decreasing transendothelial electrical resistance (TEER) (an in vitro measure of barrier integrity) (Mahajan et al.
T755 713-732 Sentence denotes 2008; Gandhi et al.
T756 733-774 Sentence denotes 2010; Mishra and Singh 2014; Patel et al.
T757 775-902 Sentence denotes 2017), with resultant paracellular “leakage” of compounds/current between compromised barrier endothelial cells (Mahajan et al.
T758 903-922 Sentence denotes 2008; Gandhi et al.
T759 923-939 Sentence denotes 2010; Wen et al.
T760 940-959 Sentence denotes 2011; McLane et al.
T761 960-981 Sentence denotes 2014; Leibrand et al.
T762 982-994 Sentence denotes 2017, 2019).
T763 995-1130 Sentence denotes Although opioids can also impair the BBB through alterations in tight junction proteins and/or increased paracellular flux (Baba et al.
T764 1131-1151 Sentence denotes 1988; Mahajan et al.
T765 1152-1168 Sentence denotes 2008; Wen et al.
T766 1169-1190 Sentence denotes 2011; Leibrand et al.
T767 1191-1351 Sentence denotes 2019), others have found that it is morphine withdrawal, not the continued exposure to morphine, that most greatly disrupts BBB integrity (Sharma and Ali 2006).
T768 1352-1511 Sentence denotes In addition to perturbing paracellular dynamics, morphine may also alter the expression and/or function of drug efflux proteins, such as P-glycoprotein (P-gp).
T769 1512-1627 Sentence denotes Sub-chronic and chronic morphine exposure is reported to increase P-gp expression and/or function (Aquilante et al.
T770 1628-1648 Sentence denotes 2000; Mahajan et al.
T771 1649-1668 Sentence denotes 2008; Yousif et al.
T772 1669-1690 Sentence denotes 2008; Leibrand et al.
T773 1691-1697 Sentence denotes 2019).
T774 1698-1795 Sentence denotes Alternatively, other investigators report no changes in P-gp with chronic exposure (Chaves et al.
T775 1796-1867 Sentence denotes 2016), while some see increases upon morphine withdrawal (Yousif et al.
T776 1868-1887 Sentence denotes 2012; Chaves et al.
T777 1888-1894 Sentence denotes 2016).
T778 1895-2032 Sentence denotes Alterations in drug transport proteins would impact the central accumulation and efficacy of therapeutic drugs that are their substrates.

2_test

Id Subject Object Predicate Lexical cue
32876803-10595922-62958107 450-454 10595922 denotes 1999
32876803-10931369-62958108 469-473 10931369 denotes 2000
32876803-22197032-62958109 568-572 22197032 denotes 2012
32876803-24965120-62958110 756-760 24965120 denotes 2014
32876803-21738771-62958111 940-944 21738771 denotes 2011
32876803-24629894-62958112 960-964 24629894 denotes 2014
32876803-28057474-62958113 982-986 28057474 denotes 2017
32876803-2841613-62958114 1131-1135 2841613 denotes 1988
32876803-21738771-62958115 1169-1173 21738771 denotes 2011
32876803-17105918-62958116 1345-1349 17105918 denotes 2006
32876803-10665989-62958117 1628-1632 10665989 denotes 2000
32876803-18761714-62958118 1669-1673 18761714 denotes 2008
32876803-26554626-62958119 1796-1800 26554626 denotes 2016
32876803-22845665-62958120 1868-1872 22845665 denotes 2012
32876803-26554626-62958121 1888-1892 26554626 denotes 2016