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PMC:7463108 / 53402-62474 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T521 0-5 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T522 6-11 Body_part denotes Brain http://purl.org/sig/ont/fma/fma50801
T523 91-94 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T524 136-139 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T525 196-201 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T526 202-207 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T527 279-282 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T528 381-384 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T529 386-389 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T530 410-413 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T531 414-422 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T532 456-470 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T533 471-479 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T534 916-933 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T535 928-933 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T536 1106-1120 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T537 1121-1129 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T538 1518-1526 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T539 1538-1550 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T540 1972-1980 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T541 2102-2107 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T542 2122-2138 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T543 2134-2138 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T544 2150-2159 Body_part denotes astrocyte http://purl.org/sig/ont/fma/fma54537
T545 2269-2272 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T546 2491-2507 Body_part denotes zonula occludens http://purl.org/sig/ont/fma/fma67397
T547 2588-2595 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T548 2766-2769 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T549 2984-2989 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T550 3095-3100 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T551 3261-3268 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T552 3516-3519 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T553 3603-3611 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T554 3646-3651 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T555 3671-3674 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T556 3733-3738 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T557 3874-3879 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T558 4649-4660 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T559 4670-4688 Body_part denotes perivascular space http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272
T561 4696-4706 Body_part denotes parenchyma http://purl.org/sig/ont/fma/fma45732
T562 4714-4722 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T563 4801-4807 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T564 4868-4872 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T565 5005-5023 Body_part denotes perivascular space http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272
T567 5024-5034 Body_part denotes parenchyma http://purl.org/sig/ont/fma/fma45732
T568 5098-5107 Body_part denotes left-hand http://purl.org/sig/ont/fma/fma9714
T569 5200-5211 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T570 5212-5234 Body_part denotes post-capillary venules http://purl.org/sig/ont/fma/fma63191
T571 5217-5226 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T572 5336-5348 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T573 5429-5441 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T574 5460-5468 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T575 5595-5601 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T576 5605-5611 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T577 5622-5630 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T578 5783-5791 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T579 5876-5882 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T580 5886-5892 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T581 6083-6086 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T582 6088-6091 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T583 6100-6108 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T584 6194-6202 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T585 6211-6222 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T586 6239-6244 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T587 6287-6298 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T588 6308-6313 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T589 6448-6451 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T590 6473-6481 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T591 6513-6516 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T592 6756-6759 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T593 6792-6795 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T594 6818-6828 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T595 7079-7087 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T596 7133-7143 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T597 7292-7296 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T598 7318-7323 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T599 7407-7410 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T600 7465-7470 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T601 7530-7544 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T602 7545-7553 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T603 7586-7594 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T604 7648-7653 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T605 7668-7676 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T606 7718-7723 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T607 7795-7798 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T608 7843-7851 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T609 7863-7868 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T610 7976-7979 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T611 8001-8006 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T612 8076-8081 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T613 8082-8087 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T614 8205-8220 Body_part denotes tight junctions http://purl.org/sig/ont/fma/fma67397
T615 8349-8354 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T616 8432-8444 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T617 8490-8495 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T618 8549-8554 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T619 8574-8577 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T620 8663-8677 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T621 8678-8686 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T622 8744-8749 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T623 8853-8859 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T624 8878-8885 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T625 8922-8927 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T626 9045-9048 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T99 0-19 Body_part denotes Blood-Brain Barrier http://purl.obolibrary.org/obo/UBERON_0000120
T100 196-215 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T101 196-201 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T102 202-207 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T103 279-282 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T104 381-384 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T105 2102-2107 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T106 2984-2989 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T107 3095-3100 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T108 3516-3519 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T109 3646-3651 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T110 3733-3738 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T111 3874-3879 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T112 4649-4660 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T113 4670-4688 Body_part denotes perivascular space http://purl.obolibrary.org/obo/UBERON_0014930
T114 4696-4706 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T115 4714-4722 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T116 4801-4807 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T117 5005-5023 Body_part denotes perivascular space http://purl.obolibrary.org/obo/UBERON_0014930
T118 5024-5034 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T119 5103-5107 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T120 5212-5234 Body_part denotes post-capillary venules http://purl.obolibrary.org/obo/UBERON_0035428
T121 5217-5226 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T122 5336-5348 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T123 5336-5341 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T124 5342-5348 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T125 5429-5441 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T126 5460-5468 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T127 5561-5566 Body_part denotes Scale http://purl.obolibrary.org/obo/UBERON_0002542
T128 5595-5601 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T129 5622-5630 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T130 5783-5791 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T131 5876-5882 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T132 6239-6244 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T133 6308-6313 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T134 6513-6516 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T135 7318-7323 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T136 7465-7470 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T137 7648-7653 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T138 7718-7723 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T139 7795-7798 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T140 7863-7868 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T141 8001-8006 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T142 8076-8095 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T143 8076-8081 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T144 8082-8087 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T145 8349-8354 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T146 8490-8495 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T147 8549-8554 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T148 8744-8749 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T149 8853-8859 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T150 8922-8927 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T139 6374-6391 Disease denotes neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T140 7207-7217 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T141 7677-7680 Disease denotes MDM http://purl.obolibrary.org/obo/MONDO_0009552
T142 7976-7989 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T143 7980-7989 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T144 8853-8866 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T145 8860-8866 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T607 0-5 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T608 0-5 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T609 6-11 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T610 6-11 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Brain
T611 196-201 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T612 196-201 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T613 202-207 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T614 202-207 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T615 279-282 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T616 279-282 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T617 279-282 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T618 381-384 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T619 381-384 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T620 381-384 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T621 462-470 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T622 916-933 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T623 1112-1120 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T624 2086-2087 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T625 2096-2101 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T626 2102-2107 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T627 2102-2107 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T628 2122-2138 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T629 2150-2159 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocyte
T630 2322-2326 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T631 2706-2711 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T632 2868-2869 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T633 2937-2944 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T634 2984-2989 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T635 2984-2989 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T636 3095-3100 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T637 3095-3100 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T638 3105-3106 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T639 3287-3288 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T640 3487-3488 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T641 3516-3519 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T642 3516-3519 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T643 3516-3519 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T644 3646-3651 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T645 3646-3651 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T646 3733-3738 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T647 3733-3738 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T648 3797-3798 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T649 3874-3879 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T650 3874-3879 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T651 3956-3961 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T652 3962-3968 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brains
T653 3962-3968 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brains
T654 4042-4043 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T655 4056-4057 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T656 4388-4389 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T657 4868-4872 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T658 5317-5318 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T659 5336-5348 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessel
T660 5336-5348 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessel
T661 5605-5611 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T662 5886-5892 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T663 6011-6012 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T664 6194-6202 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T665 6239-6244 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T666 6239-6244 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T667 6308-6313 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T668 6308-6313 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T669 6473-6481 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T670 6513-6516 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T671 6513-6516 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T672 6513-6516 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T673 6818-6828 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T674 7057-7058 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T675 7079-7087 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T676 7292-7296 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T677 7318-7323 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T678 7318-7323 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T679 7339-7343 http://purl.obolibrary.org/obo/CLO_0050768 denotes TLR2
T680 7465-7470 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T681 7465-7470 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T682 7536-7544 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T683 7648-7653 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T684 7648-7653 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T685 7668-7676 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T686 7718-7723 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T687 7718-7723 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T688 7795-7798 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T689 7795-7798 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T690 7795-7798 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T691 7863-7868 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T692 7863-7868 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T693 8001-8006 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T694 8001-8006 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T695 8076-8081 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T696 8076-8081 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T697 8082-8087 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T698 8082-8087 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T699 8211-8220 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctions
T700 8349-8354 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T701 8349-8354 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T702 8379-8380 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T703 8490-8495 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T704 8490-8495 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T705 8549-8554 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T706 8549-8554 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T707 8644-8645 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T708 8669-8677 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T709 8744-8749 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T710 8744-8749 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T711 8853-8859 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T712 8922-8927 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T713 8922-8927 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T77 358-362 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T66460 414-422 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T79 471-479 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T80 1121-1129 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T11026 1274-1282 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T36538 1325-1333 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T51283 1448-1456 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T26096 1506-1510 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T88 1518-1526 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T30663 1538-1550 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T56470 1583-1591 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T4369 1880-1888 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T5483 1957-1961 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T96748 1972-1980 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T82380 2047-2052 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T97693 2256-2264 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T99 2322-2324 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T101 2400-2408 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T34792 2423-2431 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T104 2542-2550 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T7399 2588-2595 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T80740 2621-2629 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T4988 2780-2788 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T91450 2851-2859 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T19298 2945-2953 Chemical denotes dextrans http://purl.obolibrary.org/obo/CHEBI_52071
T94726 3029-3037 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T77966 3163-3171 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T99250 3239-3243 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T76004 3261-3268 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T118 3308-3316 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T75473 3401-3409 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T72889 3474-3478 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T123 3588-3592 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T54933 3603-3611 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T125 3685-3693 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T127 3850-3856 Chemical denotes tracer http://purl.obolibrary.org/obo/CHEBI_35204
T88715 3986-3994 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T13546 4085-4093 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T66413 4221-4229 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T134 4319-4327 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T136 4377-4385 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T138 4515-4523 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T81225 4540-4548 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T142 4569-4577 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T37279 4837-4850 Chemical denotes Hoechst 33342 http://purl.obolibrary.org/obo/CHEBI_51232
T79767 4873-4879 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T42686 4934-4937 Chemical denotes DIC http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092
T5674 5063-5071 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61069 5515-5520 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T21571 5668-5676 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T2284 5713-5725 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T19714 5734-5742 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T29469 5756-5766 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T20462 5846-5854 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T49655 5970-5978 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T84615 5995-6003 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T26139 6100-6108 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T163 6461-6469 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T58500 6777-6779 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T54779 6806-6814 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T168 7005-7007 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T7125 7028-7036 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T51995 7040-7053 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T172 7233-7241 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T20102 7545-7553 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T81863 7586-7594 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T957 7629-7638 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T7188 7828-7832 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T43871 7843-7851 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T179 7909-7913 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T6618 8432-8444 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T70131 8678-8686 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T182 8878-8885 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37664 8943-8948 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T184 8975-8980 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1983 1536-1550 Gene denotes P-glycoprotein Gene:5243
1984 1552-1556 Gene denotes P-gp Gene:5243
1985 1625-1629 Gene denotes P-gp Gene:5243
1986 1801-1805 Gene denotes P-gp Gene:5243
1987 91-94 Species denotes HIV Tax:12721
1988 136-139 Species denotes HIV Tax:12721
1989 386-389 Species denotes HIV Tax:12721
1990 1274-1282 Chemical denotes morphine MESH:D009020
1991 1325-1333 Chemical denotes morphine MESH:D009020
1992 1448-1456 Chemical denotes morphine MESH:D009020
1993 1583-1591 Chemical denotes morphine MESH:D009020
1994 1880-1888 Chemical denotes morphine MESH:D009020
1995 410-422 Disease denotes HIV proteins MESH:D015658
2041 3772-3775 Gene denotes Tat Gene:234724
2042 3883-3886 Gene denotes Tat Gene:234724
2043 3912-3915 Gene denotes Tat Gene:234724
2044 4010-4013 Gene denotes Tat Gene:234724
2045 4278-4281 Gene denotes Tat Gene:234724
2046 4288-4291 Gene denotes Tat Gene:234724
2047 4470-4473 Gene denotes Tat Gene:234724
2048 4490-4493 Gene denotes Tat Gene:234724
2049 4510-4513 Gene denotes Tat Gene:234724
2050 4535-4538 Gene denotes Tat Gene:234724
2051 5654-5657 Gene denotes Tat Gene:234724
2052 5925-5928 Gene denotes Tat Gene:234724
2053 5945-5948 Gene denotes Tat Gene:234724
2054 5965-5968 Gene denotes Tat Gene:234724
2055 5990-5993 Gene denotes Tat Gene:234724
2056 3677-3680 Gene denotes Tat Gene:6898
2057 3950-3953 Gene denotes Tat Gene:234724
2058 3671-3676 Species denotes HIV-1 Tax:11676
2059 3926-3930 Species denotes mice Tax:10090
2060 3956-3961 Species denotes mouse Tax:10090
2061 4024-4028 Species denotes mice Tax:10090
2062 4549-4553 Species denotes mice Tax:10090
2063 4597-4608 Species denotes horseradish Tax:3704
2064 5080-5084 Species denotes mice Tax:10090
2065 5506-5510 Species denotes mice Tax:10090
2066 6004-6008 Species denotes mice Tax:10090
2067 3685-3693 Chemical denotes morphine MESH:D009020
2068 3986-3994 Chemical denotes morphine MESH:D009020
2069 4085-4093 Chemical denotes morphine MESH:D009020
2070 4221-4229 Chemical denotes morphine MESH:D009020
2071 4319-4327 Chemical denotes morphine MESH:D009020
2072 4377-4385 Chemical denotes morphine MESH:D009020
2073 4515-4523 Chemical denotes morphine MESH:D009020
2074 4540-4548 Chemical denotes morphine MESH:D009020
2075 4569-4577 Chemical denotes morphine MESH:D009020
2076 4837-4850 Chemical denotes Hoechst 33342 MESH:C017807
2077 5063-5071 Chemical denotes morphine MESH:D009020
2078 5668-5676 Chemical denotes morphine MESH:D009020
2079 5713-5725 Chemical denotes dolutegravir MESH:C562325
2080 5734-5742 Chemical denotes abacavir MESH:C106538
2081 5756-5766 Chemical denotes lamivudine MESH:D019259
2082 5846-5854 Chemical denotes morphine MESH:D009020
2083 5970-5978 Chemical denotes morphine MESH:D009020
2084 5995-6003 Chemical denotes morphine MESH:D009020
2085 3701-3710 Disease denotes leakiness MESH:C535298
2121 2275-2278 Gene denotes Tat Gene:6898
2122 2312-2317 Gene denotes TNF-α Gene:7124
2123 2322-2326 Gene denotes IL-8 Gene:3576
2124 2412-2415 Gene denotes Tat Gene:6898
2125 2436-2439 Gene denotes Tat Gene:6898
2126 2478-2483 Gene denotes JAM-2 Gene:58494
2127 2511-2515 Gene denotes ZO-1 Gene:7082
2128 2557-2560 Gene denotes Tat Gene:6898
2129 2579-2587 Gene denotes occludin Gene:100506658
2130 2644-2647 Gene denotes Tat Gene:6898
2131 2772-2775 Gene denotes Tat Gene:6898
2132 2884-2887 Gene denotes Tat Gene:6898
2133 3270-3274 Gene denotes P-gp Gene:5243
2134 3502-3506 Gene denotes P-gp Gene:5243
2135 2691-2694 Gene denotes Tat Gene:234724
2136 2096-2101 Species denotes human Tax:9606
2137 2269-2274 Species denotes HIV-1 Tax:11676
2138 2706-2711 Species denotes mouse Tax:10090
2139 2766-2771 Species denotes HIV-1 Tax:11676
2140 2695-2705 Species denotes transgenic Tax:10090
2141 2256-2264 Chemical denotes morphine MESH:D009020
2142 2400-2408 Chemical denotes morphine MESH:D009020
2143 2423-2431 Chemical denotes Morphine MESH:D009020
2144 2542-2550 Chemical denotes morphine MESH:D009020
2145 2621-2629 Chemical denotes morphine MESH:D009020
2146 2780-2788 Chemical denotes morphine MESH:D009020
2147 2851-2859 Chemical denotes morphine MESH:D009020
2148 2945-2953 Chemical denotes dextrans MESH:D003911
2149 3029-3037 Chemical denotes Morphine MESH:D009020
2150 3163-3171 Chemical denotes Morphine MESH:D009020
2151 3308-3316 Chemical denotes morphine MESH:D009020
2152 3401-3409 Chemical denotes morphine MESH:D009020
2153 3561-3569 Chemical denotes morphine MESH:D009020
2154 2359-2368 Disease denotes tightness MESH:C536920
2155 3083-3087 Disease denotes ARVs
2183 6453-6456 Gene denotes Tat Gene:6898
2184 6760-6763 Gene denotes Tat Gene:6898
2185 6798-6801 Gene denotes Tat Gene:6898
2186 6885-6889 Gene denotes CCL2 Gene:6347
2187 6894-6898 Gene denotes CCL5 Gene:6352
2188 6968-6971 Gene denotes MOR Gene:4988
2189 7020-7023 Gene denotes Tat Gene:6898
2190 7118-7122 Gene denotes CCL5 Gene:6352
2191 7249-7252 Gene denotes Tat Gene:234724
2192 7339-7343 Gene denotes TLR2 Gene:24088
2193 7348-7352 Gene denotes TLR4 Gene:21898
2194 6985-6989 Gene denotes Hage Gene:55510
2195 6792-6797 Species denotes HIV-1 Tax:11676
2196 7204-7217 Species denotes S. pneumoniae Tax:1313
2197 7227-7231 Species denotes mice Tax:10090
2198 6083-6086 Species denotes HIV Tax:12721
2199 6448-6451 Species denotes HIV Tax:12721
2200 6756-6759 Species denotes HIV Tax:12721
2201 6461-6469 Chemical denotes morphine MESH:D009020
2202 6806-6814 Chemical denotes morphine MESH:D009020
2203 7028-7036 Chemical denotes morphine MESH:D009020
2204 7040-7053 Chemical denotes buprenorphine MESH:D002047
2205 7233-7241 Chemical denotes morphine MESH:D009020
2206 6088-6108 Disease denotes HIV-1 viral proteins
2207 6277-6285 Disease denotes infected MESH:D007239
2209 7218-7226 Disease denotes infected MESH:D007239
2217 8430-8444 Gene denotes P-glycoprotein Gene:5243
2218 8446-8450 Gene denotes P-gp Gene:5243
2219 8832-8836 Gene denotes P-gp Gene:5243
2220 8853-8885 Gene denotes breast cancer resistance protein Gene:9429
2221 8887-8891 Gene denotes Bcrp Gene:9429
2222 8574-8577 Species denotes HIV Tax:12721
2223 9045-9048 Species denotes HIV Tax:12721
2228 7677-7680 Gene denotes MDM Gene:57152
2229 7407-7410 Species denotes HIV Tax:12721
2230 7734-7742 Disease denotes infected MESH:D007239
2231 7976-7989 Disease denotes HIV infection MESH:D015658

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T94 283-294 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T95 427-436 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T96 1511-1517 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T97 1511-1517 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T98 1536-1550 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T99 1957-1971 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T100 1962-1971 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T101 3244-3250 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T102 3244-3250 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T103 3251-3260 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T104 3588-3602 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T105 3593-3602 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T106 4597-4625 http://purl.obolibrary.org/obo/GO_0004601 denotes horseradish peroxidase (HRP)
T107 7285-7308 http://purl.obolibrary.org/obo/GO_0050900 denotes immune cell trafficking
T108 7442-7453 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T109 7472-7481 http://purl.obolibrary.org/obo/GO_0009056 denotes Breakdown
T110 7828-7842 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T111 7833-7842 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T112 8401-8407 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T113 8401-8407 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T114 8430-8444 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T115 8459-8467 http://purl.obolibrary.org/obo/GO_0140352 denotes effluxes
T116 8459-8467 http://purl.obolibrary.org/obo/GO_0140115 denotes effluxes
T117 8646-8655 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T118 8791-8797 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T119 8791-8797 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T120 8798-8809 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T743 0-46 Sentence denotes Blood-Brain Barrier and the Neurovascular Unit
T744 47-222 Sentence denotes Despite growing evidence on how opiates and HIV interact to impact the neuropathology of HIV, little is known about their interactive effects on the blood-brain barrier (BBB).
T745 223-385 Sentence denotes BBB integrity and function are critical for maintaining CNS homeostasis, and mediating neuroimmune interactions with the periphery and drug delivery into the CNS.
T746 386-496 Sentence denotes HIV and many individual HIV proteins can breakdown the BBB disrupting tight junction proteins (Dallasta et al.
T747 497-515 Sentence denotes 1999; Boven et al.
T748 516-535 Sentence denotes 2000; Andras et al.
T749 536-556 Sentence denotes 2003; Mahajan et al.
T750 557-578 Sentence denotes 2008; Banerjee et al.
T751 579-598 Sentence denotes 2010; Gandhi et al.
T752 599-614 Sentence denotes 2010; Xu et al.
T753 615-633 Sentence denotes 2012; Patel et al.
T754 634-759 Sentence denotes 2017) and decreasing transendothelial electrical resistance (TEER) (an in vitro measure of barrier integrity) (Mahajan et al.
T755 760-779 Sentence denotes 2008; Gandhi et al.
T756 780-821 Sentence denotes 2010; Mishra and Singh 2014; Patel et al.
T757 822-949 Sentence denotes 2017), with resultant paracellular “leakage” of compounds/current between compromised barrier endothelial cells (Mahajan et al.
T758 950-969 Sentence denotes 2008; Gandhi et al.
T759 970-986 Sentence denotes 2010; Wen et al.
T760 987-1006 Sentence denotes 2011; McLane et al.
T761 1007-1028 Sentence denotes 2014; Leibrand et al.
T762 1029-1041 Sentence denotes 2017, 2019).
T763 1042-1177 Sentence denotes Although opioids can also impair the BBB through alterations in tight junction proteins and/or increased paracellular flux (Baba et al.
T764 1178-1198 Sentence denotes 1988; Mahajan et al.
T765 1199-1215 Sentence denotes 2008; Wen et al.
T766 1216-1237 Sentence denotes 2011; Leibrand et al.
T767 1238-1398 Sentence denotes 2019), others have found that it is morphine withdrawal, not the continued exposure to morphine, that most greatly disrupts BBB integrity (Sharma and Ali 2006).
T768 1399-1558 Sentence denotes In addition to perturbing paracellular dynamics, morphine may also alter the expression and/or function of drug efflux proteins, such as P-glycoprotein (P-gp).
T769 1559-1674 Sentence denotes Sub-chronic and chronic morphine exposure is reported to increase P-gp expression and/or function (Aquilante et al.
T770 1675-1695 Sentence denotes 2000; Mahajan et al.
T771 1696-1715 Sentence denotes 2008; Yousif et al.
T772 1716-1737 Sentence denotes 2008; Leibrand et al.
T773 1738-1744 Sentence denotes 2019).
T774 1745-1842 Sentence denotes Alternatively, other investigators report no changes in P-gp with chronic exposure (Chaves et al.
T775 1843-1914 Sentence denotes 2016), while some see increases upon morphine withdrawal (Yousif et al.
T776 1915-1934 Sentence denotes 2012; Chaves et al.
T777 1935-1941 Sentence denotes 2016).
T778 1942-2079 Sentence denotes Alterations in drug transport proteins would impact the central accumulation and efficacy of therapeutic drugs that are their substrates.
T779 2080-2422 Sentence denotes Using a primary human brain microvascular endothelial cell (BMEC) and astrocyte co-culture model, Mahajan et al. (2008) were among the first to demonstrate that co-exposure to morphine and HIV-1 Tat resulted in greater increases in TNF-α and IL-8 levels and decreases in barrier tightness (measured by TEER) than either morphine or Tat alone.
T780 2423-2663 Sentence denotes Morphine and Tat co-exposure also additively increased JAM-2, while zonula occludens-1 (ZO-1) levels were decreased by morphine or by Tat individually, and occludin protein levels were decreased by morphine alone but not Tat (Mahajan et al.
T781 2664-2670 Sentence denotes 2008).
T782 2671-2832 Sentence denotes Using the inducible Tat transgenic mouse model, Leibrand et al. (2019), also demonstrated that HIV-1 Tat and morphine act independently to disrupt BBB integrity.
T783 2833-3006 Sentence denotes In these studies, morphine, and to a lesser extent Tat, exposure increased the leakage of fluorescently labeled dextrans from the circulation into the brain (Leibrand et al.
T784 3007-3028 Sentence denotes 2017, 2019) (Fig. 3).
T785 3029-3146 Sentence denotes Morphine exposure decreased the penetration of select ARVs in the brain, in a region-specific manner (Leibrand et al.
T786 3147-3162 Sentence denotes 2019) (Fig. 3).
T787 3163-3366 Sentence denotes Morphine exposure also resulted in increased expression and function of the drug efflux transport protein, P-gp, suggesting a mechanism by which morphine decreased the ARV concentrations (Leibrand et al.
T788 3367-3373 Sentence denotes 2019).
T789 3374-3520 Sentence denotes This finding suggests that morphine exposure could impact the efficient delivery of any therapeutic drug that is a substrate of P-gp into the CNS.
T790 3521-3652 Sentence denotes Future research should also investigate morphine’s impact on other drug transport proteins important for ARV delivery to the brain.
T791 3653-3754 Sentence denotes Fig. 3 Effects of HIV-1 Tat and morphine on BBB leakiness and on antiretroviral brain concentrations.
T792 3755-4045 Sentence denotes After 14 days of Tat induction, there was a significant increase in the 10 kDa (Cascade Blue®) tracer leakage into the brain in Tat + placebo as compared to Tat − placebo mice (*p < 0.05) and in Tat − mouse brains upon exposure to morphine as compared to Tat − placebo mice (*p < 0.05) (a).
T793 4046-4394 Sentence denotes There was a significant main effect of morphine, resulting in reduced integrity of the BBB and increased leakage of the higher molecular weight (40 kDa and 70 kDa) tracers in morphine-exposed groups as compared to the those groups (Tat + and Tat − together) not exposed to morphine (placebo) (#p < 0.05; significant main effect of morphine) (b, c).
T794 4395-4554 Sentence denotes Data represent the fold change in mean fluorescence intensity ± SEM; n = 8 Tat−/placebo, n = 6 Tat+/placebo, n = 9 Tat−/morphine, and n = 7 Tat+/morphine mice.
T795 4555-4730 Sentence denotes Additionally, morphine exposure increased horseradish peroxidase (HRP) extravasation from the vasculature into the perivascular space and/or parenchyma in the striatum (d, e).
T796 4731-4968 Sentence denotes HRP antigenicity was detected by indirect immunofluorescence (red) in tissue sections counterstained with Hoechst 33342 (blue) to reveal cell nuclei and visualized by differential interference contrast (DIC)-enhanced confocal microscopy.
T797 4969-5130 Sentence denotes HRP extravasation into the striatal perivascular space/parenchyma was especially prevalent in morphine-exposed mice (arrowheads; left-hand panels in e versus d).
T798 5131-5401 Sentence denotes The dotted lines (············) indicate the approximate edge of the capillaries/post-capillary venules; while intermittent dotted lines (· · · · · · ·) indicate the approximate edge of a partly sectioned blood vessel that appears partially outside the plane of section.
T799 5402-5469 Sentence denotes The asterisks (*) indicate white matter tracts within the striatum.
T800 5470-5521 Sentence denotes Representative samples from ≥ n = 4 mice per group.
T801 5522-5560 Sentence denotes All images are the same magnification.
T802 5561-5579 Sentence denotes Scale bar = 10 μm.
T803 5580-5637 Sentence denotes Antiretroviral tissue-to-plasma ratios in striatum (f–g).
T804 5638-5856 Sentence denotes Irrespective of Tat exposure, morphine significantly reduced the levels of dolutegravir (f) and abacavir (g), but not lamivudine (h), within the striatum, as compared to placebo. (* p < 0.05; main effect for morphine).
T805 5857-6082 Sentence denotes Data represent the tissue-to-plasma ratios ± SEM sampled from n = 9 Tat−/placebo, n = 9 Tat+/placebo, n = 6 Tat−/morphine, and n = 8 Tat+/morphine mice. (a–h) Modified and reprinted with permission from Leibrand et al. (2019)
T806 6083-6245 Sentence denotes HIV, HIV-1 viral proteins, and opiate-induced barrier dysfunction is associated with increased infiltration of monocyte-derived macrophages (MDMs) into the brain.
T807 6246-6392 Sentence denotes Enhanced influx of peripheral (infected) macrophages into the brain can serve to replenish viral reservoirs and further promote neuroinflammation.
T808 6393-6531 Sentence denotes Several studies have examined the individual impact of HIV, Tat, or morphine on monocyte adhesion or migration into the CNS (Nottet et al.
T809 6532-6547 Sentence denotes 1996; Wu et al.
T810 6548-6574 Sentence denotes 2000; Fischer-Smith et al.
T811 6575-6593 Sentence denotes 2001; Pello et al.
T812 6594-6615 Sentence denotes 2006; Williams et al.
T813 6616-6643 Sentence denotes 2013a, 2014; Strazza et al.
T814 6644-6665 Sentence denotes 2016; Leibrand et al.
T815 6666-6687 Sentence denotes 2017; Chilunda et al.
T816 6688-6694 Sentence denotes 2019).
T817 6695-6776 Sentence denotes However, fewer studies have examined the combined effects of HIV/Tat and opiates.
T818 6777-6935 Sentence denotes Co-exposure of HIV-1 Tat and morphine on astrocytes increases the production of chemoattractants, primarily CCL2 and CCL5, and increases microglial migration.
T819 6936-6996 Sentence denotes These effects were inhibited by MOR blockade (El-Hage et al.
T820 6997-7004 Sentence denotes 2006b).
T821 7005-7159 Sentence denotes Co-exposure of Tat and morphine or buprenorphine to a BBB model increases monocyte transmigration in response to CCL5 and other chemokines (Mahajan et al.
T822 7160-7193 Sentence denotes 2008; Jaureguiberry-Bravo et. al.
T823 7194-7200 Sentence denotes 2016).
T824 7201-7374 Sentence denotes In S. pneumoniae-infected mice, morphine and/or Tat exposure significantly enhances immune cell trafficking into the brain via actions at TLR2 and TLR4 (Dutta and Roy 2015).
T825 7375-7471 Sentence denotes Taken together, BBB damage from HIV and/or opiates can disrupt the homeostasis within the brain.
T826 7472-7799 Sentence denotes Breakdown of paracellular processes, through decreases in tight junction proteins and increased cellular adhesion proteins, increased leakage of circulating molecules into the brain and increased monocyte/MDM adhesion and transmigration into the brain, which if infected, can serve to replenish viral reservoirs within the CNS.
T827 7800-7929 Sentence denotes Furthermore, alterations in drug transport proteins within the brain can decrease ARV efficacy by decreasing drug concentrations.
T828 7930-8036 Sentence denotes Collectively, these changes serve to maintain HIV infection within the brain (see Fig. 4; Tables 1 and 2).
T829 8037-8143 Sentence denotes Fig. 4 Schematic representation of the blood-brain barrier and other components of the neurovascular unit.
T830 8144-8355 Sentence denotes Under normal conditions (represented above the dotted line), tight junctions are intact which restricts the leakage of paracellular, typically small hydrophilic, compounds, across the barrier and into the brain.
T831 8356-8555 Sentence denotes Additionally, there is a basal expression of efflux transporters, such as P-glycoprotein (P-gp), which effluxes substrates out of the brain, serving to restrict overall accumulation within the brain.
T832 8556-8750 Sentence denotes In the setting of HIV and opiate exposure (represented below the dotted line), there is a breakdown of the tight junction proteins and increased leakage of paracellular compounds into the brain.
T833 8751-9072 Sentence denotes Additionally, opiate exposure increases efflux transporter expression, including P-gp and potentially breast cancer resistance protein (Bcrp), thereby restricting overall brain penetration of drugs (like many antiretroviral drugs) which are substrates for these transporters and in response to HIV and/or opioid exposure.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T46 4670-4688 Phenotype denotes perivascular space http://purl.obolibrary.org/obo/HP_0012520
T47 5005-5023 Phenotype denotes perivascular space http://purl.obolibrary.org/obo/HP_0012520
T48 7207-7217 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T49 8853-8866 Phenotype denotes breast cancer http://purl.obolibrary.org/obo/HP_0003002

2_test

Id Subject Object Predicate Lexical cue
32876803-10595922-62958107 497-501 10595922 denotes 1999
32876803-10931369-62958108 516-520 10931369 denotes 2000
32876803-22197032-62958109 615-619 22197032 denotes 2012
32876803-24965120-62958110 803-807 24965120 denotes 2014
32876803-21738771-62958111 987-991 21738771 denotes 2011
32876803-24629894-62958112 1007-1011 24629894 denotes 2014
32876803-28057474-62958113 1029-1033 28057474 denotes 2017
32876803-2841613-62958114 1178-1182 2841613 denotes 1988
32876803-21738771-62958115 1216-1220 21738771 denotes 2011
32876803-17105918-62958116 1392-1396 17105918 denotes 2006
32876803-10665989-62958117 1675-1679 10665989 denotes 2000
32876803-18761714-62958118 1716-1720 18761714 denotes 2008
32876803-26554626-62958119 1843-1847 26554626 denotes 2016
32876803-22845665-62958120 1915-1919 22845665 denotes 2012
32876803-26554626-62958121 1935-1939 26554626 denotes 2016
32876803-28057474-62958122 3007-3011 28057474 denotes 2017
32876803-8558009-62958123 6532-6536 8558009 denotes 1996
32876803-24862333-62958125 6623-6627 24862333 denotes 2014
32876803-28057474-62958126 6666-6670 28057474 denotes 2017
32876803-31473221-62958127 6688-6692 31473221 denotes 2019
32876803-27009099-62958128 7194-7198 27009099 denotes 2016