PMC:7463108 / 53402-62474
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T521 | 0-5 | Body_part | denotes | Blood | http://purl.org/sig/ont/fma/fma9670 |
T522 | 6-11 | Body_part | denotes | Brain | http://purl.org/sig/ont/fma/fma50801 |
T523 | 91-94 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T524 | 136-139 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T525 | 196-201 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T526 | 202-207 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T527 | 279-282 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
T528 | 381-384 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
T529 | 386-389 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T530 | 410-413 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T531 | 414-422 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T532 | 456-470 | Body_part | denotes | tight junction | http://purl.org/sig/ont/fma/fma67397 |
T533 | 471-479 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T534 | 916-933 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
T535 | 928-933 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T536 | 1106-1120 | Body_part | denotes | tight junction | http://purl.org/sig/ont/fma/fma67397 |
T537 | 1121-1129 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T538 | 1518-1526 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T539 | 1538-1550 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T540 | 1972-1980 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T541 | 2102-2107 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T542 | 2122-2138 | Body_part | denotes | endothelial cell | http://purl.org/sig/ont/fma/fma66772 |
T543 | 2134-2138 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T544 | 2150-2159 | Body_part | denotes | astrocyte | http://purl.org/sig/ont/fma/fma54537 |
T545 | 2269-2272 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T546 | 2491-2507 | Body_part | denotes | zonula occludens | http://purl.org/sig/ont/fma/fma67397 |
T547 | 2588-2595 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T548 | 2766-2769 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T549 | 2984-2989 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T550 | 3095-3100 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T551 | 3261-3268 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T552 | 3516-3519 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
T553 | 3603-3611 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T554 | 3646-3651 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T555 | 3671-3674 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T556 | 3733-3738 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T557 | 3874-3879 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T558 | 4649-4660 | Body_part | denotes | vasculature | http://purl.org/sig/ont/fma/fma69050 |
T559 | 4670-4688 | Body_part | denotes | perivascular space | http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272 |
T561 | 4696-4706 | Body_part | denotes | parenchyma | http://purl.org/sig/ont/fma/fma45732 |
T562 | 4714-4722 | Body_part | denotes | striatum | http://purl.org/sig/ont/fma/fma77618 |
T563 | 4801-4807 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T564 | 4868-4872 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T565 | 5005-5023 | Body_part | denotes | perivascular space | http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272 |
T567 | 5024-5034 | Body_part | denotes | parenchyma | http://purl.org/sig/ont/fma/fma45732 |
T568 | 5098-5107 | Body_part | denotes | left-hand | http://purl.org/sig/ont/fma/fma9714 |
T569 | 5200-5211 | Body_part | denotes | capillaries | http://purl.org/sig/ont/fma/fma63194 |
T570 | 5212-5234 | Body_part | denotes | post-capillary venules | http://purl.org/sig/ont/fma/fma63191 |
T571 | 5217-5226 | Body_part | denotes | capillary | http://purl.org/sig/ont/fma/fma63194 |
T572 | 5336-5348 | Body_part | denotes | blood vessel | http://purl.org/sig/ont/fma/fma63183 |
T573 | 5429-5441 | Body_part | denotes | white matter | http://purl.org/sig/ont/fma/fma83929 |
T574 | 5460-5468 | Body_part | denotes | striatum | http://purl.org/sig/ont/fma/fma77618 |
T575 | 5595-5601 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T576 | 5605-5611 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
T577 | 5622-5630 | Body_part | denotes | striatum | http://purl.org/sig/ont/fma/fma77618 |
T578 | 5783-5791 | Body_part | denotes | striatum | http://purl.org/sig/ont/fma/fma77618 |
T579 | 5876-5882 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T580 | 5886-5892 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
T581 | 6083-6086 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T582 | 6088-6091 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T583 | 6100-6108 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T584 | 6194-6202 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
T585 | 6211-6222 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T586 | 6239-6244 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T587 | 6287-6298 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T588 | 6308-6313 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T589 | 6448-6451 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T590 | 6473-6481 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
T591 | 6513-6516 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
T592 | 6756-6759 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T593 | 6792-6795 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T594 | 6818-6828 | Body_part | denotes | astrocytes | http://purl.org/sig/ont/fma/fma54537 |
T595 | 7079-7087 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
T596 | 7133-7143 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
T597 | 7292-7296 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T598 | 7318-7323 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T599 | 7407-7410 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T600 | 7465-7470 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T601 | 7530-7544 | Body_part | denotes | tight junction | http://purl.org/sig/ont/fma/fma67397 |
T602 | 7545-7553 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T603 | 7586-7594 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T604 | 7648-7653 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T605 | 7668-7676 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
T606 | 7718-7723 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T607 | 7795-7798 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
T608 | 7843-7851 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T609 | 7863-7868 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T610 | 7976-7979 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T611 | 8001-8006 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T612 | 8076-8081 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T613 | 8082-8087 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T614 | 8205-8220 | Body_part | denotes | tight junctions | http://purl.org/sig/ont/fma/fma67397 |
T615 | 8349-8354 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T616 | 8432-8444 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T617 | 8490-8495 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T618 | 8549-8554 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T619 | 8574-8577 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T620 | 8663-8677 | Body_part | denotes | tight junction | http://purl.org/sig/ont/fma/fma67397 |
T621 | 8678-8686 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T622 | 8744-8749 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T623 | 8853-8859 | Body_part | denotes | breast | http://purl.org/sig/ont/fma/fma9601 |
T624 | 8878-8885 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T625 | 8922-8927 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
T626 | 9045-9048 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T99 | 0-19 | Body_part | denotes | Blood-Brain Barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
T100 | 196-215 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
T101 | 196-201 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T102 | 202-207 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T103 | 279-282 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
T104 | 381-384 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
T105 | 2102-2107 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T106 | 2984-2989 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T107 | 3095-3100 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T108 | 3516-3519 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
T109 | 3646-3651 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T110 | 3733-3738 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T111 | 3874-3879 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T112 | 4649-4660 | Body_part | denotes | vasculature | http://purl.obolibrary.org/obo/UBERON_0002049 |
T113 | 4670-4688 | Body_part | denotes | perivascular space | http://purl.obolibrary.org/obo/UBERON_0014930 |
T114 | 4696-4706 | Body_part | denotes | parenchyma | http://purl.obolibrary.org/obo/UBERON_0000353 |
T115 | 4714-4722 | Body_part | denotes | striatum | http://purl.obolibrary.org/obo/UBERON_0002435 |
T116 | 4801-4807 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T117 | 5005-5023 | Body_part | denotes | perivascular space | http://purl.obolibrary.org/obo/UBERON_0014930 |
T118 | 5024-5034 | Body_part | denotes | parenchyma | http://purl.obolibrary.org/obo/UBERON_0000353 |
T119 | 5103-5107 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
T120 | 5212-5234 | Body_part | denotes | post-capillary venules | http://purl.obolibrary.org/obo/UBERON_0035428 |
T121 | 5217-5226 | Body_part | denotes | capillary | http://purl.obolibrary.org/obo/UBERON_0001982 |
T122 | 5336-5348 | Body_part | denotes | blood vessel | http://purl.obolibrary.org/obo/UBERON_0001981 |
T123 | 5336-5341 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T124 | 5342-5348 | Body_part | denotes | vessel | http://purl.obolibrary.org/obo/UBERON_0000055 |
T125 | 5429-5441 | Body_part | denotes | white matter | http://purl.obolibrary.org/obo/UBERON_0002316 |
T126 | 5460-5468 | Body_part | denotes | striatum | http://purl.obolibrary.org/obo/UBERON_0002435 |
T127 | 5561-5566 | Body_part | denotes | Scale | http://purl.obolibrary.org/obo/UBERON_0002542 |
T128 | 5595-5601 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T129 | 5622-5630 | Body_part | denotes | striatum | http://purl.obolibrary.org/obo/UBERON_0002435 |
T130 | 5783-5791 | Body_part | denotes | striatum | http://purl.obolibrary.org/obo/UBERON_0002435 |
T131 | 5876-5882 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
T132 | 6239-6244 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T133 | 6308-6313 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T134 | 6513-6516 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
T135 | 7318-7323 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T136 | 7465-7470 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T137 | 7648-7653 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T138 | 7718-7723 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T139 | 7795-7798 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
T140 | 7863-7868 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T141 | 8001-8006 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T142 | 8076-8095 | Body_part | denotes | blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
T143 | 8076-8081 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T144 | 8082-8087 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T145 | 8349-8354 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T146 | 8490-8495 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T147 | 8549-8554 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T148 | 8744-8749 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
T149 | 8853-8859 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T150 | 8922-8927 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T139 | 6374-6391 | Disease | denotes | neuroinflammation | http://purl.obolibrary.org/obo/MONDO_0004466 |
T140 | 7207-7217 | Disease | denotes | pneumoniae | http://purl.obolibrary.org/obo/MONDO_0005249 |
T141 | 7677-7680 | Disease | denotes | MDM | http://purl.obolibrary.org/obo/MONDO_0009552 |
T142 | 7976-7989 | Disease | denotes | HIV infection | http://purl.obolibrary.org/obo/MONDO_0005109 |
T143 | 7980-7989 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T144 | 8853-8866 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T145 | 8860-8866 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T607 | 0-5 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | Blood |
T608 | 0-5 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | Blood |
T609 | 6-11 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | Brain |
T610 | 6-11 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | Brain |
T611 | 196-201 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T612 | 196-201 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T613 | 202-207 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T614 | 202-207 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T615 | 279-282 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
T616 | 279-282 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
T617 | 279-282 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
T618 | 381-384 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
T619 | 381-384 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
T620 | 381-384 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
T621 | 462-470 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junction |
T622 | 916-933 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
T623 | 1112-1120 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junction |
T624 | 2086-2087 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T625 | 2096-2101 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T626 | 2102-2107 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T627 | 2102-2107 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T628 | 2122-2138 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cell |
T629 | 2150-2159 | http://purl.obolibrary.org/obo/CL_0000127 | denotes | astrocyte |
T630 | 2322-2326 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
T631 | 2706-2711 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T632 | 2868-2869 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T633 | 2937-2944 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | labeled |
T634 | 2984-2989 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T635 | 2984-2989 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T636 | 3095-3100 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T637 | 3095-3100 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T638 | 3105-3106 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T639 | 3287-3288 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T640 | 3487-3488 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T641 | 3516-3519 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
T642 | 3516-3519 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
T643 | 3516-3519 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
T644 | 3646-3651 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T645 | 3646-3651 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T646 | 3733-3738 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T647 | 3733-3738 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T648 | 3797-3798 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T649 | 3874-3879 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T650 | 3874-3879 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T651 | 3956-3961 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T652 | 3962-3968 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brains |
T653 | 3962-3968 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brains |
T654 | 4042-4043 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T655 | 4056-4057 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T656 | 4388-4389 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T657 | 4868-4872 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T658 | 5317-5318 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T659 | 5336-5348 | http://purl.obolibrary.org/obo/UBERON_0001981 | denotes | blood vessel |
T660 | 5336-5348 | http://www.ebi.ac.uk/efo/EFO_0000817 | denotes | blood vessel |
T661 | 5605-5611 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
T662 | 5886-5892 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
T663 | 6011-6012 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T664 | 6194-6202 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
T665 | 6239-6244 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T666 | 6239-6244 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T667 | 6308-6313 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T668 | 6308-6313 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T669 | 6473-6481 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
T670 | 6513-6516 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
T671 | 6513-6516 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
T672 | 6513-6516 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
T673 | 6818-6828 | http://purl.obolibrary.org/obo/CL_0000127 | denotes | astrocytes |
T674 | 7057-7058 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T675 | 7079-7087 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
T676 | 7292-7296 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T677 | 7318-7323 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T678 | 7318-7323 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T679 | 7339-7343 | http://purl.obolibrary.org/obo/CLO_0050768 | denotes | TLR2 |
T680 | 7465-7470 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T681 | 7465-7470 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T682 | 7536-7544 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junction |
T683 | 7648-7653 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T684 | 7648-7653 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T685 | 7668-7676 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
T686 | 7718-7723 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T687 | 7718-7723 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T688 | 7795-7798 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
T689 | 7795-7798 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
T690 | 7795-7798 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
T691 | 7863-7868 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T692 | 7863-7868 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T693 | 8001-8006 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T694 | 8001-8006 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T695 | 8076-8081 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T696 | 8076-8081 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T697 | 8082-8087 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T698 | 8082-8087 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T699 | 8211-8220 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junctions |
T700 | 8349-8354 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T701 | 8349-8354 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T702 | 8379-8380 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T703 | 8490-8495 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T704 | 8490-8495 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T705 | 8549-8554 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T706 | 8549-8554 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T707 | 8644-8645 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T708 | 8669-8677 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junction |
T709 | 8744-8749 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T710 | 8744-8749 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
T711 | 8853-8859 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
T712 | 8922-8927 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
T713 | 8922-8927 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T77 | 358-362 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T66460 | 414-422 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T79 | 471-479 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T80 | 1121-1129 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T11026 | 1274-1282 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T36538 | 1325-1333 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T51283 | 1448-1456 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T26096 | 1506-1510 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T88 | 1518-1526 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T30663 | 1538-1550 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T56470 | 1583-1591 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T4369 | 1880-1888 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T5483 | 1957-1961 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T96748 | 1972-1980 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T82380 | 2047-2052 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T97693 | 2256-2264 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T99 | 2322-2324 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T101 | 2400-2408 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T34792 | 2423-2431 | Chemical | denotes | Morphine | http://purl.obolibrary.org/obo/CHEBI_17303 |
T104 | 2542-2550 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T7399 | 2588-2595 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T80740 | 2621-2629 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T4988 | 2780-2788 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T91450 | 2851-2859 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T19298 | 2945-2953 | Chemical | denotes | dextrans | http://purl.obolibrary.org/obo/CHEBI_52071 |
T94726 | 3029-3037 | Chemical | denotes | Morphine | http://purl.obolibrary.org/obo/CHEBI_17303 |
T77966 | 3163-3171 | Chemical | denotes | Morphine | http://purl.obolibrary.org/obo/CHEBI_17303 |
T99250 | 3239-3243 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T76004 | 3261-3268 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T118 | 3308-3316 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T75473 | 3401-3409 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T72889 | 3474-3478 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T123 | 3588-3592 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T54933 | 3603-3611 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T125 | 3685-3693 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T127 | 3850-3856 | Chemical | denotes | tracer | http://purl.obolibrary.org/obo/CHEBI_35204 |
T88715 | 3986-3994 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T13546 | 4085-4093 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T66413 | 4221-4229 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T134 | 4319-4327 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T136 | 4377-4385 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T138 | 4515-4523 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T81225 | 4540-4548 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T142 | 4569-4577 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T37279 | 4837-4850 | Chemical | denotes | Hoechst 33342 | http://purl.obolibrary.org/obo/CHEBI_51232 |
T79767 | 4873-4879 | Chemical | denotes | nuclei | http://purl.obolibrary.org/obo/CHEBI_33252 |
T42686 | 4934-4937 | Chemical | denotes | DIC | http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092 |
T5674 | 5063-5071 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T61069 | 5515-5520 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
T21571 | 5668-5676 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T2284 | 5713-5725 | Chemical | denotes | dolutegravir | http://purl.obolibrary.org/obo/CHEBI_76010 |
T19714 | 5734-5742 | Chemical | denotes | abacavir | http://purl.obolibrary.org/obo/CHEBI_421707 |
T29469 | 5756-5766 | Chemical | denotes | lamivudine | http://purl.obolibrary.org/obo/CHEBI_63577 |
T20462 | 5846-5854 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T49655 | 5970-5978 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T84615 | 5995-6003 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T26139 | 6100-6108 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T163 | 6461-6469 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T58500 | 6777-6779 | Chemical | denotes | Co | http://purl.obolibrary.org/obo/CHEBI_27638 |
T54779 | 6806-6814 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T168 | 7005-7007 | Chemical | denotes | Co | http://purl.obolibrary.org/obo/CHEBI_27638 |
T7125 | 7028-7036 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T51995 | 7040-7053 | Chemical | denotes | buprenorphine | http://purl.obolibrary.org/obo/CHEBI_3216 |
T172 | 7233-7241 | Chemical | denotes | morphine | http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097 |
T20102 | 7545-7553 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T81863 | 7586-7594 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T957 | 7629-7638 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T7188 | 7828-7832 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T43871 | 7843-7851 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T179 | 7909-7913 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T6618 | 8432-8444 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T70131 | 8678-8686 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T182 | 8878-8885 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T37664 | 8943-8948 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T184 | 8975-8980 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1983 | 1536-1550 | Gene | denotes | P-glycoprotein | Gene:5243 |
1984 | 1552-1556 | Gene | denotes | P-gp | Gene:5243 |
1985 | 1625-1629 | Gene | denotes | P-gp | Gene:5243 |
1986 | 1801-1805 | Gene | denotes | P-gp | Gene:5243 |
1987 | 91-94 | Species | denotes | HIV | Tax:12721 |
1988 | 136-139 | Species | denotes | HIV | Tax:12721 |
1989 | 386-389 | Species | denotes | HIV | Tax:12721 |
1990 | 1274-1282 | Chemical | denotes | morphine | MESH:D009020 |
1991 | 1325-1333 | Chemical | denotes | morphine | MESH:D009020 |
1992 | 1448-1456 | Chemical | denotes | morphine | MESH:D009020 |
1993 | 1583-1591 | Chemical | denotes | morphine | MESH:D009020 |
1994 | 1880-1888 | Chemical | denotes | morphine | MESH:D009020 |
1995 | 410-422 | Disease | denotes | HIV proteins | MESH:D015658 |
2041 | 3772-3775 | Gene | denotes | Tat | Gene:234724 |
2042 | 3883-3886 | Gene | denotes | Tat | Gene:234724 |
2043 | 3912-3915 | Gene | denotes | Tat | Gene:234724 |
2044 | 4010-4013 | Gene | denotes | Tat | Gene:234724 |
2045 | 4278-4281 | Gene | denotes | Tat | Gene:234724 |
2046 | 4288-4291 | Gene | denotes | Tat | Gene:234724 |
2047 | 4470-4473 | Gene | denotes | Tat | Gene:234724 |
2048 | 4490-4493 | Gene | denotes | Tat | Gene:234724 |
2049 | 4510-4513 | Gene | denotes | Tat | Gene:234724 |
2050 | 4535-4538 | Gene | denotes | Tat | Gene:234724 |
2051 | 5654-5657 | Gene | denotes | Tat | Gene:234724 |
2052 | 5925-5928 | Gene | denotes | Tat | Gene:234724 |
2053 | 5945-5948 | Gene | denotes | Tat | Gene:234724 |
2054 | 5965-5968 | Gene | denotes | Tat | Gene:234724 |
2055 | 5990-5993 | Gene | denotes | Tat | Gene:234724 |
2056 | 3677-3680 | Gene | denotes | Tat | Gene:6898 |
2057 | 3950-3953 | Gene | denotes | Tat | Gene:234724 |
2058 | 3671-3676 | Species | denotes | HIV-1 | Tax:11676 |
2059 | 3926-3930 | Species | denotes | mice | Tax:10090 |
2060 | 3956-3961 | Species | denotes | mouse | Tax:10090 |
2061 | 4024-4028 | Species | denotes | mice | Tax:10090 |
2062 | 4549-4553 | Species | denotes | mice | Tax:10090 |
2063 | 4597-4608 | Species | denotes | horseradish | Tax:3704 |
2064 | 5080-5084 | Species | denotes | mice | Tax:10090 |
2065 | 5506-5510 | Species | denotes | mice | Tax:10090 |
2066 | 6004-6008 | Species | denotes | mice | Tax:10090 |
2067 | 3685-3693 | Chemical | denotes | morphine | MESH:D009020 |
2068 | 3986-3994 | Chemical | denotes | morphine | MESH:D009020 |
2069 | 4085-4093 | Chemical | denotes | morphine | MESH:D009020 |
2070 | 4221-4229 | Chemical | denotes | morphine | MESH:D009020 |
2071 | 4319-4327 | Chemical | denotes | morphine | MESH:D009020 |
2072 | 4377-4385 | Chemical | denotes | morphine | MESH:D009020 |
2073 | 4515-4523 | Chemical | denotes | morphine | MESH:D009020 |
2074 | 4540-4548 | Chemical | denotes | morphine | MESH:D009020 |
2075 | 4569-4577 | Chemical | denotes | morphine | MESH:D009020 |
2076 | 4837-4850 | Chemical | denotes | Hoechst 33342 | MESH:C017807 |
2077 | 5063-5071 | Chemical | denotes | morphine | MESH:D009020 |
2078 | 5668-5676 | Chemical | denotes | morphine | MESH:D009020 |
2079 | 5713-5725 | Chemical | denotes | dolutegravir | MESH:C562325 |
2080 | 5734-5742 | Chemical | denotes | abacavir | MESH:C106538 |
2081 | 5756-5766 | Chemical | denotes | lamivudine | MESH:D019259 |
2082 | 5846-5854 | Chemical | denotes | morphine | MESH:D009020 |
2083 | 5970-5978 | Chemical | denotes | morphine | MESH:D009020 |
2084 | 5995-6003 | Chemical | denotes | morphine | MESH:D009020 |
2085 | 3701-3710 | Disease | denotes | leakiness | MESH:C535298 |
2121 | 2275-2278 | Gene | denotes | Tat | Gene:6898 |
2122 | 2312-2317 | Gene | denotes | TNF-α | Gene:7124 |
2123 | 2322-2326 | Gene | denotes | IL-8 | Gene:3576 |
2124 | 2412-2415 | Gene | denotes | Tat | Gene:6898 |
2125 | 2436-2439 | Gene | denotes | Tat | Gene:6898 |
2126 | 2478-2483 | Gene | denotes | JAM-2 | Gene:58494 |
2127 | 2511-2515 | Gene | denotes | ZO-1 | Gene:7082 |
2128 | 2557-2560 | Gene | denotes | Tat | Gene:6898 |
2129 | 2579-2587 | Gene | denotes | occludin | Gene:100506658 |
2130 | 2644-2647 | Gene | denotes | Tat | Gene:6898 |
2131 | 2772-2775 | Gene | denotes | Tat | Gene:6898 |
2132 | 2884-2887 | Gene | denotes | Tat | Gene:6898 |
2133 | 3270-3274 | Gene | denotes | P-gp | Gene:5243 |
2134 | 3502-3506 | Gene | denotes | P-gp | Gene:5243 |
2135 | 2691-2694 | Gene | denotes | Tat | Gene:234724 |
2136 | 2096-2101 | Species | denotes | human | Tax:9606 |
2137 | 2269-2274 | Species | denotes | HIV-1 | Tax:11676 |
2138 | 2706-2711 | Species | denotes | mouse | Tax:10090 |
2139 | 2766-2771 | Species | denotes | HIV-1 | Tax:11676 |
2140 | 2695-2705 | Species | denotes | transgenic | Tax:10090 |
2141 | 2256-2264 | Chemical | denotes | morphine | MESH:D009020 |
2142 | 2400-2408 | Chemical | denotes | morphine | MESH:D009020 |
2143 | 2423-2431 | Chemical | denotes | Morphine | MESH:D009020 |
2144 | 2542-2550 | Chemical | denotes | morphine | MESH:D009020 |
2145 | 2621-2629 | Chemical | denotes | morphine | MESH:D009020 |
2146 | 2780-2788 | Chemical | denotes | morphine | MESH:D009020 |
2147 | 2851-2859 | Chemical | denotes | morphine | MESH:D009020 |
2148 | 2945-2953 | Chemical | denotes | dextrans | MESH:D003911 |
2149 | 3029-3037 | Chemical | denotes | Morphine | MESH:D009020 |
2150 | 3163-3171 | Chemical | denotes | Morphine | MESH:D009020 |
2151 | 3308-3316 | Chemical | denotes | morphine | MESH:D009020 |
2152 | 3401-3409 | Chemical | denotes | morphine | MESH:D009020 |
2153 | 3561-3569 | Chemical | denotes | morphine | MESH:D009020 |
2154 | 2359-2368 | Disease | denotes | tightness | MESH:C536920 |
2155 | 3083-3087 | Disease | denotes | ARVs | |
2183 | 6453-6456 | Gene | denotes | Tat | Gene:6898 |
2184 | 6760-6763 | Gene | denotes | Tat | Gene:6898 |
2185 | 6798-6801 | Gene | denotes | Tat | Gene:6898 |
2186 | 6885-6889 | Gene | denotes | CCL2 | Gene:6347 |
2187 | 6894-6898 | Gene | denotes | CCL5 | Gene:6352 |
2188 | 6968-6971 | Gene | denotes | MOR | Gene:4988 |
2189 | 7020-7023 | Gene | denotes | Tat | Gene:6898 |
2190 | 7118-7122 | Gene | denotes | CCL5 | Gene:6352 |
2191 | 7249-7252 | Gene | denotes | Tat | Gene:234724 |
2192 | 7339-7343 | Gene | denotes | TLR2 | Gene:24088 |
2193 | 7348-7352 | Gene | denotes | TLR4 | Gene:21898 |
2194 | 6985-6989 | Gene | denotes | Hage | Gene:55510 |
2195 | 6792-6797 | Species | denotes | HIV-1 | Tax:11676 |
2196 | 7204-7217 | Species | denotes | S. pneumoniae | Tax:1313 |
2197 | 7227-7231 | Species | denotes | mice | Tax:10090 |
2198 | 6083-6086 | Species | denotes | HIV | Tax:12721 |
2199 | 6448-6451 | Species | denotes | HIV | Tax:12721 |
2200 | 6756-6759 | Species | denotes | HIV | Tax:12721 |
2201 | 6461-6469 | Chemical | denotes | morphine | MESH:D009020 |
2202 | 6806-6814 | Chemical | denotes | morphine | MESH:D009020 |
2203 | 7028-7036 | Chemical | denotes | morphine | MESH:D009020 |
2204 | 7040-7053 | Chemical | denotes | buprenorphine | MESH:D002047 |
2205 | 7233-7241 | Chemical | denotes | morphine | MESH:D009020 |
2206 | 6088-6108 | Disease | denotes | HIV-1 viral proteins | |
2207 | 6277-6285 | Disease | denotes | infected | MESH:D007239 |
2209 | 7218-7226 | Disease | denotes | infected | MESH:D007239 |
2217 | 8430-8444 | Gene | denotes | P-glycoprotein | Gene:5243 |
2218 | 8446-8450 | Gene | denotes | P-gp | Gene:5243 |
2219 | 8832-8836 | Gene | denotes | P-gp | Gene:5243 |
2220 | 8853-8885 | Gene | denotes | breast cancer resistance protein | Gene:9429 |
2221 | 8887-8891 | Gene | denotes | Bcrp | Gene:9429 |
2222 | 8574-8577 | Species | denotes | HIV | Tax:12721 |
2223 | 9045-9048 | Species | denotes | HIV | Tax:12721 |
2228 | 7677-7680 | Gene | denotes | MDM | Gene:57152 |
2229 | 7407-7410 | Species | denotes | HIV | Tax:12721 |
2230 | 7734-7742 | Disease | denotes | infected | MESH:D007239 |
2231 | 7976-7989 | Disease | denotes | HIV infection | MESH:D015658 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T94 | 283-294 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
T95 | 427-436 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | breakdown |
T96 | 1511-1517 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T97 | 1511-1517 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T98 | 1536-1550 | http://purl.obolibrary.org/obo/GO_0008559 | denotes | P-glycoprotein |
T99 | 1957-1971 | http://purl.obolibrary.org/obo/GO_0015893 | denotes | drug transport |
T100 | 1962-1971 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
T101 | 3244-3250 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T102 | 3244-3250 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T103 | 3251-3260 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
T104 | 3588-3602 | http://purl.obolibrary.org/obo/GO_0015893 | denotes | drug transport |
T105 | 3593-3602 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
T106 | 4597-4625 | http://purl.obolibrary.org/obo/GO_0004601 | denotes | horseradish peroxidase (HRP) |
T107 | 7285-7308 | http://purl.obolibrary.org/obo/GO_0050900 | denotes | immune cell trafficking |
T108 | 7442-7453 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
T109 | 7472-7481 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | Breakdown |
T110 | 7828-7842 | http://purl.obolibrary.org/obo/GO_0015893 | denotes | drug transport |
T111 | 7833-7842 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
T112 | 8401-8407 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T113 | 8401-8407 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T114 | 8430-8444 | http://purl.obolibrary.org/obo/GO_0008559 | denotes | P-glycoprotein |
T115 | 8459-8467 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | effluxes |
T116 | 8459-8467 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | effluxes |
T117 | 8646-8655 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | breakdown |
T118 | 8791-8797 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T119 | 8791-8797 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T120 | 8798-8809 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transporter |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T743 | 0-46 | Sentence | denotes | Blood-Brain Barrier and the Neurovascular Unit |
T744 | 47-222 | Sentence | denotes | Despite growing evidence on how opiates and HIV interact to impact the neuropathology of HIV, little is known about their interactive effects on the blood-brain barrier (BBB). |
T745 | 223-385 | Sentence | denotes | BBB integrity and function are critical for maintaining CNS homeostasis, and mediating neuroimmune interactions with the periphery and drug delivery into the CNS. |
T746 | 386-496 | Sentence | denotes | HIV and many individual HIV proteins can breakdown the BBB disrupting tight junction proteins (Dallasta et al. |
T747 | 497-515 | Sentence | denotes | 1999; Boven et al. |
T748 | 516-535 | Sentence | denotes | 2000; Andras et al. |
T749 | 536-556 | Sentence | denotes | 2003; Mahajan et al. |
T750 | 557-578 | Sentence | denotes | 2008; Banerjee et al. |
T751 | 579-598 | Sentence | denotes | 2010; Gandhi et al. |
T752 | 599-614 | Sentence | denotes | 2010; Xu et al. |
T753 | 615-633 | Sentence | denotes | 2012; Patel et al. |
T754 | 634-759 | Sentence | denotes | 2017) and decreasing transendothelial electrical resistance (TEER) (an in vitro measure of barrier integrity) (Mahajan et al. |
T755 | 760-779 | Sentence | denotes | 2008; Gandhi et al. |
T756 | 780-821 | Sentence | denotes | 2010; Mishra and Singh 2014; Patel et al. |
T757 | 822-949 | Sentence | denotes | 2017), with resultant paracellular “leakage” of compounds/current between compromised barrier endothelial cells (Mahajan et al. |
T758 | 950-969 | Sentence | denotes | 2008; Gandhi et al. |
T759 | 970-986 | Sentence | denotes | 2010; Wen et al. |
T760 | 987-1006 | Sentence | denotes | 2011; McLane et al. |
T761 | 1007-1028 | Sentence | denotes | 2014; Leibrand et al. |
T762 | 1029-1041 | Sentence | denotes | 2017, 2019). |
T763 | 1042-1177 | Sentence | denotes | Although opioids can also impair the BBB through alterations in tight junction proteins and/or increased paracellular flux (Baba et al. |
T764 | 1178-1198 | Sentence | denotes | 1988; Mahajan et al. |
T765 | 1199-1215 | Sentence | denotes | 2008; Wen et al. |
T766 | 1216-1237 | Sentence | denotes | 2011; Leibrand et al. |
T767 | 1238-1398 | Sentence | denotes | 2019), others have found that it is morphine withdrawal, not the continued exposure to morphine, that most greatly disrupts BBB integrity (Sharma and Ali 2006). |
T768 | 1399-1558 | Sentence | denotes | In addition to perturbing paracellular dynamics, morphine may also alter the expression and/or function of drug efflux proteins, such as P-glycoprotein (P-gp). |
T769 | 1559-1674 | Sentence | denotes | Sub-chronic and chronic morphine exposure is reported to increase P-gp expression and/or function (Aquilante et al. |
T770 | 1675-1695 | Sentence | denotes | 2000; Mahajan et al. |
T771 | 1696-1715 | Sentence | denotes | 2008; Yousif et al. |
T772 | 1716-1737 | Sentence | denotes | 2008; Leibrand et al. |
T773 | 1738-1744 | Sentence | denotes | 2019). |
T774 | 1745-1842 | Sentence | denotes | Alternatively, other investigators report no changes in P-gp with chronic exposure (Chaves et al. |
T775 | 1843-1914 | Sentence | denotes | 2016), while some see increases upon morphine withdrawal (Yousif et al. |
T776 | 1915-1934 | Sentence | denotes | 2012; Chaves et al. |
T777 | 1935-1941 | Sentence | denotes | 2016). |
T778 | 1942-2079 | Sentence | denotes | Alterations in drug transport proteins would impact the central accumulation and efficacy of therapeutic drugs that are their substrates. |
T779 | 2080-2422 | Sentence | denotes | Using a primary human brain microvascular endothelial cell (BMEC) and astrocyte co-culture model, Mahajan et al. (2008) were among the first to demonstrate that co-exposure to morphine and HIV-1 Tat resulted in greater increases in TNF-α and IL-8 levels and decreases in barrier tightness (measured by TEER) than either morphine or Tat alone. |
T780 | 2423-2663 | Sentence | denotes | Morphine and Tat co-exposure also additively increased JAM-2, while zonula occludens-1 (ZO-1) levels were decreased by morphine or by Tat individually, and occludin protein levels were decreased by morphine alone but not Tat (Mahajan et al. |
T781 | 2664-2670 | Sentence | denotes | 2008). |
T782 | 2671-2832 | Sentence | denotes | Using the inducible Tat transgenic mouse model, Leibrand et al. (2019), also demonstrated that HIV-1 Tat and morphine act independently to disrupt BBB integrity. |
T783 | 2833-3006 | Sentence | denotes | In these studies, morphine, and to a lesser extent Tat, exposure increased the leakage of fluorescently labeled dextrans from the circulation into the brain (Leibrand et al. |
T784 | 3007-3028 | Sentence | denotes | 2017, 2019) (Fig. 3). |
T785 | 3029-3146 | Sentence | denotes | Morphine exposure decreased the penetration of select ARVs in the brain, in a region-specific manner (Leibrand et al. |
T786 | 3147-3162 | Sentence | denotes | 2019) (Fig. 3). |
T787 | 3163-3366 | Sentence | denotes | Morphine exposure also resulted in increased expression and function of the drug efflux transport protein, P-gp, suggesting a mechanism by which morphine decreased the ARV concentrations (Leibrand et al. |
T788 | 3367-3373 | Sentence | denotes | 2019). |
T789 | 3374-3520 | Sentence | denotes | This finding suggests that morphine exposure could impact the efficient delivery of any therapeutic drug that is a substrate of P-gp into the CNS. |
T790 | 3521-3652 | Sentence | denotes | Future research should also investigate morphine’s impact on other drug transport proteins important for ARV delivery to the brain. |
T791 | 3653-3754 | Sentence | denotes | Fig. 3 Effects of HIV-1 Tat and morphine on BBB leakiness and on antiretroviral brain concentrations. |
T792 | 3755-4045 | Sentence | denotes | After 14 days of Tat induction, there was a significant increase in the 10 kDa (Cascade Blue®) tracer leakage into the brain in Tat + placebo as compared to Tat − placebo mice (*p < 0.05) and in Tat − mouse brains upon exposure to morphine as compared to Tat − placebo mice (*p < 0.05) (a). |
T793 | 4046-4394 | Sentence | denotes | There was a significant main effect of morphine, resulting in reduced integrity of the BBB and increased leakage of the higher molecular weight (40 kDa and 70 kDa) tracers in morphine-exposed groups as compared to the those groups (Tat + and Tat − together) not exposed to morphine (placebo) (#p < 0.05; significant main effect of morphine) (b, c). |
T794 | 4395-4554 | Sentence | denotes | Data represent the fold change in mean fluorescence intensity ± SEM; n = 8 Tat−/placebo, n = 6 Tat+/placebo, n = 9 Tat−/morphine, and n = 7 Tat+/morphine mice. |
T795 | 4555-4730 | Sentence | denotes | Additionally, morphine exposure increased horseradish peroxidase (HRP) extravasation from the vasculature into the perivascular space and/or parenchyma in the striatum (d, e). |
T796 | 4731-4968 | Sentence | denotes | HRP antigenicity was detected by indirect immunofluorescence (red) in tissue sections counterstained with Hoechst 33342 (blue) to reveal cell nuclei and visualized by differential interference contrast (DIC)-enhanced confocal microscopy. |
T797 | 4969-5130 | Sentence | denotes | HRP extravasation into the striatal perivascular space/parenchyma was especially prevalent in morphine-exposed mice (arrowheads; left-hand panels in e versus d). |
T798 | 5131-5401 | Sentence | denotes | The dotted lines (············) indicate the approximate edge of the capillaries/post-capillary venules; while intermittent dotted lines (· · · · · · ·) indicate the approximate edge of a partly sectioned blood vessel that appears partially outside the plane of section. |
T799 | 5402-5469 | Sentence | denotes | The asterisks (*) indicate white matter tracts within the striatum. |
T800 | 5470-5521 | Sentence | denotes | Representative samples from ≥ n = 4 mice per group. |
T801 | 5522-5560 | Sentence | denotes | All images are the same magnification. |
T802 | 5561-5579 | Sentence | denotes | Scale bar = 10 μm. |
T803 | 5580-5637 | Sentence | denotes | Antiretroviral tissue-to-plasma ratios in striatum (f–g). |
T804 | 5638-5856 | Sentence | denotes | Irrespective of Tat exposure, morphine significantly reduced the levels of dolutegravir (f) and abacavir (g), but not lamivudine (h), within the striatum, as compared to placebo. (* p < 0.05; main effect for morphine). |
T805 | 5857-6082 | Sentence | denotes | Data represent the tissue-to-plasma ratios ± SEM sampled from n = 9 Tat−/placebo, n = 9 Tat+/placebo, n = 6 Tat−/morphine, and n = 8 Tat+/morphine mice. (a–h) Modified and reprinted with permission from Leibrand et al. (2019) |
T806 | 6083-6245 | Sentence | denotes | HIV, HIV-1 viral proteins, and opiate-induced barrier dysfunction is associated with increased infiltration of monocyte-derived macrophages (MDMs) into the brain. |
T807 | 6246-6392 | Sentence | denotes | Enhanced influx of peripheral (infected) macrophages into the brain can serve to replenish viral reservoirs and further promote neuroinflammation. |
T808 | 6393-6531 | Sentence | denotes | Several studies have examined the individual impact of HIV, Tat, or morphine on monocyte adhesion or migration into the CNS (Nottet et al. |
T809 | 6532-6547 | Sentence | denotes | 1996; Wu et al. |
T810 | 6548-6574 | Sentence | denotes | 2000; Fischer-Smith et al. |
T811 | 6575-6593 | Sentence | denotes | 2001; Pello et al. |
T812 | 6594-6615 | Sentence | denotes | 2006; Williams et al. |
T813 | 6616-6643 | Sentence | denotes | 2013a, 2014; Strazza et al. |
T814 | 6644-6665 | Sentence | denotes | 2016; Leibrand et al. |
T815 | 6666-6687 | Sentence | denotes | 2017; Chilunda et al. |
T816 | 6688-6694 | Sentence | denotes | 2019). |
T817 | 6695-6776 | Sentence | denotes | However, fewer studies have examined the combined effects of HIV/Tat and opiates. |
T818 | 6777-6935 | Sentence | denotes | Co-exposure of HIV-1 Tat and morphine on astrocytes increases the production of chemoattractants, primarily CCL2 and CCL5, and increases microglial migration. |
T819 | 6936-6996 | Sentence | denotes | These effects were inhibited by MOR blockade (El-Hage et al. |
T820 | 6997-7004 | Sentence | denotes | 2006b). |
T821 | 7005-7159 | Sentence | denotes | Co-exposure of Tat and morphine or buprenorphine to a BBB model increases monocyte transmigration in response to CCL5 and other chemokines (Mahajan et al. |
T822 | 7160-7193 | Sentence | denotes | 2008; Jaureguiberry-Bravo et. al. |
T823 | 7194-7200 | Sentence | denotes | 2016). |
T824 | 7201-7374 | Sentence | denotes | In S. pneumoniae-infected mice, morphine and/or Tat exposure significantly enhances immune cell trafficking into the brain via actions at TLR2 and TLR4 (Dutta and Roy 2015). |
T825 | 7375-7471 | Sentence | denotes | Taken together, BBB damage from HIV and/or opiates can disrupt the homeostasis within the brain. |
T826 | 7472-7799 | Sentence | denotes | Breakdown of paracellular processes, through decreases in tight junction proteins and increased cellular adhesion proteins, increased leakage of circulating molecules into the brain and increased monocyte/MDM adhesion and transmigration into the brain, which if infected, can serve to replenish viral reservoirs within the CNS. |
T827 | 7800-7929 | Sentence | denotes | Furthermore, alterations in drug transport proteins within the brain can decrease ARV efficacy by decreasing drug concentrations. |
T828 | 7930-8036 | Sentence | denotes | Collectively, these changes serve to maintain HIV infection within the brain (see Fig. 4; Tables 1 and 2). |
T829 | 8037-8143 | Sentence | denotes | Fig. 4 Schematic representation of the blood-brain barrier and other components of the neurovascular unit. |
T830 | 8144-8355 | Sentence | denotes | Under normal conditions (represented above the dotted line), tight junctions are intact which restricts the leakage of paracellular, typically small hydrophilic, compounds, across the barrier and into the brain. |
T831 | 8356-8555 | Sentence | denotes | Additionally, there is a basal expression of efflux transporters, such as P-glycoprotein (P-gp), which effluxes substrates out of the brain, serving to restrict overall accumulation within the brain. |
T832 | 8556-8750 | Sentence | denotes | In the setting of HIV and opiate exposure (represented below the dotted line), there is a breakdown of the tight junction proteins and increased leakage of paracellular compounds into the brain. |
T833 | 8751-9072 | Sentence | denotes | Additionally, opiate exposure increases efflux transporter expression, including P-gp and potentially breast cancer resistance protein (Bcrp), thereby restricting overall brain penetration of drugs (like many antiretroviral drugs) which are substrates for these transporters and in response to HIV and/or opioid exposure. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T46 | 4670-4688 | Phenotype | denotes | perivascular space | http://purl.obolibrary.org/obo/HP_0012520 |
T47 | 5005-5023 | Phenotype | denotes | perivascular space | http://purl.obolibrary.org/obo/HP_0012520 |
T48 | 7207-7217 | Phenotype | denotes | pneumoniae | http://purl.obolibrary.org/obo/HP_0002090 |
T49 | 8853-8866 | Phenotype | denotes | breast cancer | http://purl.obolibrary.org/obo/HP_0003002 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32876803-10595922-62958107 | 497-501 | 10595922 | denotes | 1999 |
32876803-10931369-62958108 | 516-520 | 10931369 | denotes | 2000 |
32876803-22197032-62958109 | 615-619 | 22197032 | denotes | 2012 |
32876803-24965120-62958110 | 803-807 | 24965120 | denotes | 2014 |
32876803-21738771-62958111 | 987-991 | 21738771 | denotes | 2011 |
32876803-24629894-62958112 | 1007-1011 | 24629894 | denotes | 2014 |
32876803-28057474-62958113 | 1029-1033 | 28057474 | denotes | 2017 |
32876803-2841613-62958114 | 1178-1182 | 2841613 | denotes | 1988 |
32876803-21738771-62958115 | 1216-1220 | 21738771 | denotes | 2011 |
32876803-17105918-62958116 | 1392-1396 | 17105918 | denotes | 2006 |
32876803-10665989-62958117 | 1675-1679 | 10665989 | denotes | 2000 |
32876803-18761714-62958118 | 1716-1720 | 18761714 | denotes | 2008 |
32876803-26554626-62958119 | 1843-1847 | 26554626 | denotes | 2016 |
32876803-22845665-62958120 | 1915-1919 | 22845665 | denotes | 2012 |
32876803-26554626-62958121 | 1935-1939 | 26554626 | denotes | 2016 |
32876803-28057474-62958122 | 3007-3011 | 28057474 | denotes | 2017 |
32876803-8558009-62958123 | 6532-6536 | 8558009 | denotes | 1996 |
32876803-24862333-62958125 | 6623-6627 | 24862333 | denotes | 2014 |
32876803-28057474-62958126 | 6666-6670 | 28057474 | denotes | 2017 |
32876803-31473221-62958127 | 6688-6692 | 31473221 | denotes | 2019 |
32876803-27009099-62958128 | 7194-7198 | 27009099 | denotes | 2016 |