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PMC:7463108 / 50858-52508 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T505 48-51 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T506 688-691 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T507 764-771 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T508 845-854 Body_part denotes dendrites http://purl.org/sig/ont/fma/fma67314
T509 942-955 Body_part denotes aspartic acid http://purl.org/sig/ont/fma/fma82760
T510 1561-1568 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T136 732-738 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T596 124-125 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T597 374-375 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T598 1071-1079 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T599 1085-1086 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T600 1579-1580 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T601 1581-1582 http://purl.obolibrary.org/obo/CLO_0001021 denotes b

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T56524 0-8 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T22 80-89 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T54050 91-94 Chemical denotes RyR http://purl.obolibrary.org/obo/CHEBI_8925
T24 183-192 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T4899 202-211 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T26 216-224 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T553 252-260 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61869 291-301 Chemical denotes Nimodipine http://purl.obolibrary.org/obo/CHEBI_7575
T41653 336-346 Chemical denotes dantrolene http://purl.obolibrary.org/obo/CHEBI_4317
T31 415-424 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T4654 464-472 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T47424 537-547 Chemical denotes nimodipine http://purl.obolibrary.org/obo/CHEBI_7575
T96207 549-559 Chemical denotes dantrolene http://purl.obolibrary.org/obo/CHEBI_4317
T9447 564-572 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T14570 636-638 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T32988 640-642 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T39702 656-664 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T69404 702-710 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T44 790-798 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T46 861-866 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T68016 869-876 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T48 879-885 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T50651 907-911 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T52793 931-955 Chemical denotes N-methyl-D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_31882
T29928 933-939 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T65599 940-955 Chemical denotes D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_17364
T6522 942-955 Chemical denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T67050 951-955 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T85819 1004-1006 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T58 1047-1049 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T79856 1101-1104 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T12888 1154-1156 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T38030 1162-1164 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T87801 1276-1284 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3614 1323-1325 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T82906 1345-1352 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T40213 1409-1418 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T28773 1420-1423 Chemical denotes RyR http://purl.obolibrary.org/obo/CHEBI_8925
T21964 1458-1466 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T33921 1561-1568 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1839 91-94 Gene denotes RyR Gene:6262
1840 127-130 Gene denotes Tat Gene:6898
1841 694-697 Gene denotes Tat Gene:6898
1842 979-982 Gene denotes MOR Gene:4988
1843 1420-1423 Gene denotes RyR Gene:6262
1844 1487-1490 Gene denotes MOR Gene:4988
1845 1268-1271 Gene denotes Tat Gene:6898
1846 782-785 Gene denotes Tat Gene:6898
1847 644-647 Gene denotes Tat Gene:6898
1848 611-614 Gene denotes Tat Gene:6898
1849 456-459 Gene denotes Tat Gene:6898
1850 244-247 Gene denotes Tat Gene:6898
1851 52-55 Gene denotes Tat Gene:6898
1852 688-693 Species denotes HIV-1 Tax:11676
1853 48-51 Species denotes HIV Tax:12721
1854 0-8 Chemical denotes Morphine MESH:D009020
1855 70-74 Chemical denotes Ca2+ MESH:D000069285
1856 80-89 Chemical denotes ryanodine MESH:D012433
1857 153-157 Chemical denotes Ca2+ MESH:D000069285
1858 183-192 Chemical denotes ryanodine MESH:D012433
1859 202-211 Chemical denotes ryanodine MESH:D012433
1860 216-224 Chemical denotes pyruvate MESH:D019289
1861 252-260 Chemical denotes morphine MESH:D009020
1862 283-287 Chemical denotes Ca2+ MESH:D000069285
1863 291-301 Chemical denotes Nimodipine MESH:D009553
1864 310-314 Chemical denotes Ca2+ MESH:D000069285
1865 336-346 Chemical denotes dantrolene MESH:D003620
1866 386-390 Chemical denotes Ca2+ MESH:D000069285
1867 415-424 Chemical denotes ryanodine MESH:D012433
1868 464-472 Chemical denotes morphine MESH:D009020
1869 495-499 Chemical denotes Ca2+ MESH:D000069285
1870 537-547 Chemical denotes nimodipine MESH:D009553
1871 549-559 Chemical denotes dantrolene MESH:D003620
1872 564-572 Chemical denotes pyruvate MESH:D019289
1873 656-664 Chemical denotes Morphine MESH:D009020
1874 702-710 Chemical denotes morphine MESH:D009020
1875 1237-1241 Chemical denotes Ca2+ MESH:D000069285
1876 1276-1284 Chemical denotes morphine MESH:D009020
1877 1345-1352 Chemical denotes calcium MESH:D002118
1878 1409-1418 Chemical denotes ryanodine MESH:D012433
1879 1458-1466 Chemical denotes morphine MESH:D009020
1880 1531-1535 Chemical denotes Ca2+ MESH:D000069285
1881 723-738 Disease denotes neuronal injury MESH:D009410

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T90 1244-1255 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T91 1345-1365 http://purl.obolibrary.org/obo/GO_0051209 denotes calcium mobilization

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T732 291-643 Sentence denotes Nimodipine (L-type Ca2+ channel blocker) and dantrolene did not show any effects. (b) Average [Ca2+]i over 10 min indicated ryanodine significantly blocked combined Tat and morphine-induced increases in [Ca2+]i, whereas no effects were noted for nimodipine, dantrolene, or pyruvate. *p < 0.05 vs. control, #p < 0.05 vs. Tat 50 nM, §p < 0.05 vs. TM, TM:
T733 644-772 Sentence denotes Tat 50 nM + Morphine 500 nM. (c) Summary of HIV-1 Tat and morphine interactive neuronal injury in striatal medium spiny neurons.
T734 773-1218 Sentence denotes Combined Tat and morphine promotes structural and functional defects in dendrites via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR), N-methyl-D-aspartic acid receptors (NMDAR), and MOR, causing influxes of Na+ and/or Ca2+, compensatory increases in Na+/K+-dependent ATPase activity, and a rapid loss in ATP mobilization with an inability to extrude excess Na+ via Na+/K+-ATPase caused by mitochondrial hyperpolarization.
T735 1219-1650 Sentence denotes Dysregulation of [Ca2+]i homeostasis by combined Tat and morphine appears to be mediated downstream of [Na+]i at the level of calcium mobilization, which in turn appears to be regulated via ryanodine (RyR)-sensitive sites, and enhanced by morphine exposure likely via MOR-dependent stimulation of PI3-kinase and Ca2+ mobilization via the Gβγ protein subunit. (a-b) Modified and reprinted with permission from Fitting et al. (2014a)