> top > docs > PMC:7463108 > spans > 49461-52508 > annotations

PMC:7463108 / 49461-52508 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T495 21-24 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T496 112-115 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T497 155-164 Body_part denotes dendritic http://purl.org/sig/ont/fma/fma67314
T498 208-215 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T499 251-255 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T500 395-404 Body_part denotes dendritic http://purl.org/sig/ont/fma/fma67314
T501 782-789 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T502 1128-1136 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T503 1295-1302 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T504 1315-1322 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T505 1445-1448 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T506 2085-2088 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T507 2161-2168 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T508 2242-2251 Body_part denotes dendrites http://purl.org/sig/ont/fma/fma67314
T509 2339-2352 Body_part denotes aspartic acid http://purl.org/sig/ont/fma/fma82760
T510 2958-2965 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T134 33-46 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T135 165-171 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T136 2129-2135 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T591 431-432 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T592 566-567 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T593 600-608 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T594 702-703 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T595 1112-1122 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T596 1521-1522 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T597 1771-1772 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T598 2468-2476 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T599 2482-2483 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T600 2976-2977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T601 2978-2979 http://purl.obolibrary.org/obo/CLO_0001021 denotes b

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T19918 78-86 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T97552 135-138 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T32116 322-330 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T64562 493-495 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T5757 532-534 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T9480 547-550 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T12334 758-766 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T12 879-887 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T64066 930-933 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T15 976-985 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T80163 1053-1061 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T11885 1128-1136 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T19 1178-1180 Chemical denotes Al http://purl.obolibrary.org/obo/CHEBI_28984
T22795 1315-1322 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T56524 1397-1405 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T22 1477-1486 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T54050 1488-1491 Chemical denotes RyR http://purl.obolibrary.org/obo/CHEBI_8925
T24 1580-1589 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T4899 1599-1608 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T26 1613-1621 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T553 1649-1657 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61869 1688-1698 Chemical denotes Nimodipine http://purl.obolibrary.org/obo/CHEBI_7575
T41653 1733-1743 Chemical denotes dantrolene http://purl.obolibrary.org/obo/CHEBI_4317
T31 1812-1821 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T4654 1861-1869 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T47424 1934-1944 Chemical denotes nimodipine http://purl.obolibrary.org/obo/CHEBI_7575
T96207 1946-1956 Chemical denotes dantrolene http://purl.obolibrary.org/obo/CHEBI_4317
T9447 1961-1969 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T14570 2033-2035 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T32988 2037-2039 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T39702 2053-2061 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T69404 2099-2107 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T44 2187-2195 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T46 2258-2263 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T68016 2266-2273 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T48 2276-2282 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T50651 2304-2308 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T52793 2328-2352 Chemical denotes N-methyl-D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_31882
T29928 2330-2336 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T65599 2337-2352 Chemical denotes D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_17364
T6522 2339-2352 Chemical denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T67050 2348-2352 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T85819 2401-2403 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T58 2444-2446 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T79856 2498-2501 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T12888 2551-2553 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T38030 2559-2561 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T87801 2673-2681 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3614 2720-2722 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T82906 2742-2749 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T40213 2806-2815 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T28773 2817-2820 Chemical denotes RyR http://purl.obolibrary.org/obo/CHEBI_8925
T21964 2855-2863 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T33921 2958-2965 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1839 1488-1491 Gene denotes RyR Gene:6262
1840 1524-1527 Gene denotes Tat Gene:6898
1841 2091-2094 Gene denotes Tat Gene:6898
1842 2376-2379 Gene denotes MOR Gene:4988
1843 2817-2820 Gene denotes RyR Gene:6262
1844 2884-2887 Gene denotes MOR Gene:4988
1845 2665-2668 Gene denotes Tat Gene:6898
1846 2179-2182 Gene denotes Tat Gene:6898
1847 2041-2044 Gene denotes Tat Gene:6898
1848 2008-2011 Gene denotes Tat Gene:6898
1849 1853-1856 Gene denotes Tat Gene:6898
1850 1641-1644 Gene denotes Tat Gene:6898
1851 1449-1452 Gene denotes Tat Gene:6898
1852 2085-2090 Species denotes HIV-1 Tax:11676
1853 1445-1448 Species denotes HIV Tax:12721
1854 1397-1405 Chemical denotes Morphine MESH:D009020
1855 1467-1471 Chemical denotes Ca2+ MESH:D000069285
1856 1477-1486 Chemical denotes ryanodine MESH:D012433
1857 1550-1554 Chemical denotes Ca2+ MESH:D000069285
1858 1580-1589 Chemical denotes ryanodine MESH:D012433
1859 1599-1608 Chemical denotes ryanodine MESH:D012433
1860 1613-1621 Chemical denotes pyruvate MESH:D019289
1861 1649-1657 Chemical denotes morphine MESH:D009020
1862 1680-1684 Chemical denotes Ca2+ MESH:D000069285
1863 1688-1698 Chemical denotes Nimodipine MESH:D009553
1864 1707-1711 Chemical denotes Ca2+ MESH:D000069285
1865 1733-1743 Chemical denotes dantrolene MESH:D003620
1866 1783-1787 Chemical denotes Ca2+ MESH:D000069285
1867 1812-1821 Chemical denotes ryanodine MESH:D012433
1868 1861-1869 Chemical denotes morphine MESH:D009020
1869 1892-1896 Chemical denotes Ca2+ MESH:D000069285
1870 1934-1944 Chemical denotes nimodipine MESH:D009553
1871 1946-1956 Chemical denotes dantrolene MESH:D003620
1872 1961-1969 Chemical denotes pyruvate MESH:D019289
1873 2053-2061 Chemical denotes Morphine MESH:D009020
1874 2099-2107 Chemical denotes morphine MESH:D009020
1875 2634-2638 Chemical denotes Ca2+ MESH:D000069285
1876 2673-2681 Chemical denotes morphine MESH:D009020
1877 2742-2749 Chemical denotes calcium MESH:D002118
1878 2806-2815 Chemical denotes ryanodine MESH:D012433
1879 2855-2863 Chemical denotes morphine MESH:D009020
1880 2928-2932 Chemical denotes Ca2+ MESH:D000069285
1881 2120-2135 Disease denotes neuronal injury MESH:D009410
1910 335-338 Gene denotes Tat Gene:6898
1911 377-380 Gene denotes Tat Gene:6898
1912 433-436 Gene denotes MOR Gene:4988
1913 704-707 Gene denotes MOR Gene:18390
1914 795-798 Gene denotes MOR Gene:18390
1915 829-833 Gene denotes TLR4 Gene:21898
1916 900-903 Gene denotes Tat Gene:234724
1917 989-993 Gene denotes RyR2 Gene:6262
1918 1081-1084 Gene denotes MOR Gene:18390
1919 1207-1210 Gene denotes MOR Gene:18390
1920 116-119 Gene denotes Tat Gene:6898
1921 808-812 Species denotes mice Tax:10090
1922 21-24 Species denotes HIV Tax:12721
1923 112-115 Species denotes HIV Tax:12721
1924 78-86 Chemical denotes morphine MESH:D009020
1925 322-330 Chemical denotes morphine MESH:D009020
1926 509-513 Chemical denotes Ca2+ MESH:D000069285
1927 547-550 Chemical denotes ATP MESH:D000255
1928 656-664 Chemical denotes morphine MESH:D009020
1929 758-766 Chemical denotes morphine MESH:D009020
1930 879-887 Chemical denotes morphine MESH:D009020
1931 961-965 Chemical denotes Ca2+ MESH:D000069285
1932 976-985 Chemical denotes ryanodine MESH:D012433
1933 1053-1061 Chemical denotes morphine MESH:D009020
1934 1251-1255 Chemical denotes Ca2+ MESH:D000069285
1935 33-56 Disease denotes neurotoxicity via glial MESH:D020258
1936 155-171 Disease denotes dendritic injury MESH:D007635
1937 389-426 Disease denotes focal dendritic varicosities/swelling MESH:D014647

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T85 135-150 http://purl.obolibrary.org/obo/GO_0050801 denotes ion homeostasis
T86 139-150 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T87 364-373 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T88 930-945 http://purl.obolibrary.org/obo/GO_0050801 denotes ion homeostasis
T89 934-945 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T90 2641-2652 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T91 2742-2762 http://purl.obolibrary.org/obo/GO_0051209 denotes calcium mobilization

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T718 0-304 Sentence denotes Besides accentuating HIV-induced neurotoxicity via glial-mediated mechanisms, morphine appears to converge with HIV Tat to dysregulate ion homeostasis and dendritic injury through potential direct actions on neurons, even though some contributions of glia cannot be excluded in this study (Fitting et al.
T719 305-312 Sentence denotes 2014a).
T720 313-634 Sentence denotes Combined morphine and Tat exposure accelerates the formation of Tat-induced focal dendritic varicosities/swelling via a MOR-related mechanism that was caused by focal increases in Na+ influx and [Ca2+]i, an overload of Na+/K+-ATPase, ATP depletion, and a collapse in mitochondrial inner membrane potential (Fitting et al.
T721 635-642 Sentence denotes 2014a).
T722 643-861 Sentence denotes Importantly, morphine’s additive effects were mediated via a MOR-related mechanism, as the exacerbating effects of morphine were absent in neurons from MOR knockout mice, thus excluding TLR4 involvement (Fitting et al.
T723 862-869 Sentence denotes 2014a).
T724 870-1026 Sentence denotes Further, morphine exacerbated Tat-dependent focal losses in ion homeostasis by mobilizing [Ca2+]i through ryanodine-2 (RyR2)-sensitive sites (Fitting et al.
T725 1027-1043 Sentence denotes 2014a) (Fig. 2).
T726 1044-1151 Sentence denotes Although morphine typically acts via MOR in an inhibitory manner by activating Gi/o-proteins (Sharma et al.
T727 1152-1171 Sentence denotes 1977; Moises et al.
T728 1172-1285 Sentence denotes 1994; Al-Hasani and Bruchas 2011), MOR-dependent stimulation of PI3-kinase and Ca2+ mobilization (Leopoldt et al.
T729 1286-1346 Sentence denotes 1998) in neurons via the Gβγ protein subunit (Mathews et al.
T730 1347-1389 Sentence denotes 2008) is presumed operative here (Fig. 2).
T731 1390-1687 Sentence denotes Fig. 2 Morphine exacerbates the excitotoxic effects of HIV Tat by mobilizing Ca2+ from ryanodine (RyR)-sensitive internal stores. (a) Tat-induced increases in [Ca2+]i were not attenuated by ryanodine, whereas ryanodine and pyruvate attenuate combined Tat and morphine-induced increases in [Ca2+]i.
T732 1688-2040 Sentence denotes Nimodipine (L-type Ca2+ channel blocker) and dantrolene did not show any effects. (b) Average [Ca2+]i over 10 min indicated ryanodine significantly blocked combined Tat and morphine-induced increases in [Ca2+]i, whereas no effects were noted for nimodipine, dantrolene, or pyruvate. *p < 0.05 vs. control, #p < 0.05 vs. Tat 50 nM, §p < 0.05 vs. TM, TM:
T733 2041-2169 Sentence denotes Tat 50 nM + Morphine 500 nM. (c) Summary of HIV-1 Tat and morphine interactive neuronal injury in striatal medium spiny neurons.
T734 2170-2615 Sentence denotes Combined Tat and morphine promotes structural and functional defects in dendrites via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR), N-methyl-D-aspartic acid receptors (NMDAR), and MOR, causing influxes of Na+ and/or Ca2+, compensatory increases in Na+/K+-dependent ATPase activity, and a rapid loss in ATP mobilization with an inability to extrude excess Na+ via Na+/K+-ATPase caused by mitochondrial hyperpolarization.
T735 2616-3047 Sentence denotes Dysregulation of [Ca2+]i homeostasis by combined Tat and morphine appears to be mediated downstream of [Na+]i at the level of calcium mobilization, which in turn appears to be regulated via ryanodine (RyR)-sensitive sites, and enhanced by morphine exposure likely via MOR-dependent stimulation of PI3-kinase and Ca2+ mobilization via the Gβγ protein subunit. (a-b) Modified and reprinted with permission from Fitting et al. (2014a)

2_test

Id Subject Object Predicate Lexical cue
32876803-269396-62958101 1152-1156 269396 denotes 1977
32876803-7931552-62958102 1172-1176 7931552 denotes 1994
32876803-22020140-62958103 1200-1204 22020140 denotes 2011