PMC:7463108 / 49413-53331 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"Opioid and HIV Interactive Pathology in Neurons\nBesides accentuating HIV-induced neurotoxicity via glial-mediated mechanisms, morphine appears to converge with HIV Tat to dysregulate ion homeostasis and dendritic injury through potential direct actions on neurons, even though some contributions of glia cannot be excluded in this study (Fitting et al. 2014a). Combined morphine and Tat exposure accelerates the formation of Tat-induced focal dendritic varicosities/swelling via a MOR-related mechanism that was caused by focal increases in Na+ influx and [Ca2+]i, an overload of Na+/K+-ATPase, ATP depletion, and a collapse in mitochondrial inner membrane potential (Fitting et al. 2014a). Importantly, morphine’s additive effects were mediated via a MOR-related mechanism, as the exacerbating effects of morphine were absent in neurons from MOR knockout mice, thus excluding TLR4 involvement (Fitting et al. 2014a). Further, morphine exacerbated Tat-dependent focal losses in ion homeostasis by mobilizing [Ca2+]i through ryanodine-2 (RyR2)-sensitive sites (Fitting et al. 2014a) (Fig. 2). Although morphine typically acts via MOR in an inhibitory manner by activating Gi/o-proteins (Sharma et al. 1977; Moises et al. 1994; Al-Hasani and Bruchas 2011), MOR-dependent stimulation of PI3-kinase and Ca2+ mobilization (Leopoldt et al. 1998) in neurons via the Gβγ protein subunit (Mathews et al. 2008) is presumed operative here (Fig. 2).\nFig. 2 Morphine exacerbates the excitotoxic effects of HIV Tat by mobilizing Ca2+ from ryanodine (RyR)-sensitive internal stores. (a) Tat-induced increases in [Ca2+]i were not attenuated by ryanodine, whereas ryanodine and pyruvate attenuate combined Tat and morphine-induced increases in [Ca2+]i. Nimodipine (L-type Ca2+ channel blocker) and dantrolene did not show any effects. (b) Average [Ca2+]i over 10 min indicated ryanodine significantly blocked combined Tat and morphine-induced increases in [Ca2+]i, whereas no effects were noted for nimodipine, dantrolene, or pyruvate. *p \u003c 0.05 vs. control, #p \u003c 0.05 vs. Tat 50 nM, §p \u003c 0.05 vs. TM, TM: Tat 50 nM + Morphine 500 nM. (c) Summary of HIV-1 Tat and morphine interactive neuronal injury in striatal medium spiny neurons. Combined Tat and morphine promotes structural and functional defects in dendrites via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR), N-methyl-D-aspartic acid receptors (NMDAR), and MOR, causing influxes of Na+ and/or Ca2+, compensatory increases in Na+/K+-dependent ATPase activity, and a rapid loss in ATP mobilization with an inability to extrude excess Na+ via Na+/K+-ATPase caused by mitochondrial hyperpolarization. Dysregulation of [Ca2+]i homeostasis by combined Tat and morphine appears to be mediated downstream of [Na+]i at the level of calcium mobilization, which in turn appears to be regulated via ryanodine (RyR)-sensitive sites, and enhanced by morphine exposure likely via MOR-dependent stimulation of PI3-kinase and Ca2+ mobilization via the Gβγ protein subunit. (a-b) Modified and reprinted with permission from Fitting et al. (2014a)\nGlial-derived neuronal injury is not unidirectional. Neuronal damage-associated molecular patterns (DAMPs) and dysfunction can trigger both infected and uninfected glia to become reactive, resulting in further neuronal damage and escalating pathology. Neuronal injury can reactivate HIV in latently infected microglia (Alvarez-Carbonell et al. 2019). While the events underlying the disruption of neuronal-microglial activation that trigger the emergence of latent HIV are unclear, the induction of HIV expression appears to involve the production of DAMPs by injured neurons and can be turned “on”, e.g., by methamphetamine-induced sigma-1 (σ1) receptor activation, TNF-α and IL-1β, and TLR3 activation can be turned “off” by CX3CL1/fractalkine or glucocorticoid receptor activation (Alvarez-Carbonell et al. 2017, 2019).","divisions":[{"label":"title","span":{"begin":0,"end":47}},{"label":"p","span":{"begin":48,"end":3095}},{"label":"figure","span":{"begin":1438,"end":3095}},{"label":"label","span":{"begin":1438,"end":1444}},{"label":"caption","span":{"begin":1445,"end":3095}},{"label":"p","span":{"begin":1445,"end":3095}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T493","span":{"begin":11,"end":14},"obj":"Body_part"},{"id":"T494","span":{"begin":40,"end":47},"obj":"Body_part"},{"id":"T495","span":{"begin":69,"end":72},"obj":"Body_part"},{"id":"T496","span":{"begin":160,"end":163},"obj":"Body_part"},{"id":"T497","span":{"begin":203,"end":212},"obj":"Body_part"},{"id":"T498","span":{"begin":256,"end":263},"obj":"Body_part"},{"id":"T499","span":{"begin":299,"end":303},"obj":"Body_part"},{"id":"T500","span":{"begin":443,"end":452},"obj":"Body_part"},{"id":"T501","span":{"begin":830,"end":837},"obj":"Body_part"},{"id":"T502","span":{"begin":1176,"end":1184},"obj":"Body_part"},{"id":"T503","span":{"begin":1343,"end":1350},"obj":"Body_part"},{"id":"T504","span":{"begin":1363,"end":1370},"obj":"Body_part"},{"id":"T505","span":{"begin":1493,"end":1496},"obj":"Body_part"},{"id":"T506","span":{"begin":2133,"end":2136},"obj":"Body_part"},{"id":"T507","span":{"begin":2209,"end":2216},"obj":"Body_part"},{"id":"T508","span":{"begin":2290,"end":2299},"obj":"Body_part"},{"id":"T509","span":{"begin":2387,"end":2400},"obj":"Body_part"},{"id":"T510","span":{"begin":3006,"end":3013},"obj":"Body_part"},{"id":"T511","span":{"begin":3149,"end":3157},"obj":"Body_part"},{"id":"T512","span":{"begin":3260,"end":3264},"obj":"Body_part"},{"id":"T513","span":{"begin":3348,"end":3356},"obj":"Body_part"},{"id":"T514","span":{"begin":3379,"end":3382},"obj":"Body_part"},{"id":"T515","span":{"begin":3404,"end":3413},"obj":"Body_part"},{"id":"T516","span":{"begin":3561,"end":3564},"obj":"Body_part"},{"id":"T517","span":{"begin":3595,"end":3598},"obj":"Body_part"},{"id":"T518","span":{"begin":3664,"end":3671},"obj":"Body_part"},{"id":"T519","span":{"begin":3773,"end":3777},"obj":"Body_part"}],"attributes":[{"id":"A493","pred":"fma_id","subj":"T493","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A494","pred":"fma_id","subj":"T494","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A495","pred":"fma_id","subj":"T495","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A496","pred":"fma_id","subj":"T496","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A497","pred":"fma_id","subj":"T497","obj":"http://purl.org/sig/ont/fma/fma67314"},{"id":"A498","pred":"fma_id","subj":"T498","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A499","pred":"fma_id","subj":"T499","obj":"http://purl.org/sig/ont/fma/fma54541"},{"id":"A500","pred":"fma_id","subj":"T500","obj":"http://purl.org/sig/ont/fma/fma67314"},{"id":"A501","pred":"fma_id","subj":"T501","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A502","pred":"fma_id","subj":"T502","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A503","pred":"fma_id","subj":"T503","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A504","pred":"fma_id","subj":"T504","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A505","pred":"fma_id","subj":"T505","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A506","pred":"fma_id","subj":"T506","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A507","pred":"fma_id","subj":"T507","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A508","pred":"fma_id","subj":"T508","obj":"http://purl.org/sig/ont/fma/fma67314"},{"id":"A509","pred":"fma_id","subj":"T509","obj":"http://purl.org/sig/ont/fma/fma82760"},{"id":"A510","pred":"fma_id","subj":"T510","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A511","pred":"fma_id","subj":"T511","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A512","pred":"fma_id","subj":"T512","obj":"http://purl.org/sig/ont/fma/fma54541"},{"id":"A513","pred":"fma_id","subj":"T513","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A514","pred":"fma_id","subj":"T514","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A515","pred":"fma_id","subj":"T515","obj":"http://purl.org/sig/ont/fma/fma68923"},{"id":"A516","pred":"fma_id","subj":"T516","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A517","pred":"fma_id","subj":"T517","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A518","pred":"fma_id","subj":"T518","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A519","pred":"fma_id","subj":"T519","obj":"http://purl.org/sig/ont/fma/fma86583"},{"subj":"T493","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T494","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T495","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T496","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T497","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T498","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T499","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T500","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T501","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T502","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T503","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T504","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T505","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T506","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T507","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T508","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T509","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T510","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T511","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T512","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T513","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T514","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T515","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T516","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T517","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T518","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T519","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T134","span":{"begin":81,"end":94},"obj":"Disease"},{"id":"T135","span":{"begin":213,"end":219},"obj":"Disease"},{"id":"T136","span":{"begin":2177,"end":2183},"obj":"Disease"},{"id":"T137","span":{"begin":3119,"end":3125},"obj":"Disease"},{"id":"T138","span":{"begin":3357,"end":3363},"obj":"Disease"}],"attributes":[{"id":"A134","pred":"mondo_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/MONDO_0005527"},{"id":"A135","pred":"mondo_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A136","pred":"mondo_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A137","pred":"mondo_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A138","pred":"mondo_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T135","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T136","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T591","span":{"begin":479,"end":480},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T592","span":{"begin":614,"end":615},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T593","span":{"begin":648,"end":656},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T594","span":{"begin":750,"end":751},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T595","span":{"begin":1160,"end":1170},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T596","span":{"begin":1569,"end":1570},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T597","span":{"begin":1819,"end":1820},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T598","span":{"begin":2516,"end":2524},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T599","span":{"begin":2530,"end":2531},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T600","span":{"begin":3024,"end":3025},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T601","span":{"begin":3026,"end":3027},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T602","span":{"begin":3404,"end":3413},"obj":"http://purl.obolibrary.org/obo/CL_0000129"},{"id":"T603","span":{"begin":3513,"end":3523},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T604","span":{"begin":3751,"end":3761},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T605","span":{"begin":3789,"end":3799},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T606","span":{"begin":3869,"end":3879},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T591","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T592","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T593","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T594","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T595","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T596","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T597","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T598","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T599","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T600","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T601","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T602","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T603","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T604","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T605","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T606","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T19918","span":{"begin":126,"end":134},"obj":"Chemical"},{"id":"T97552","span":{"begin":183,"end":186},"obj":"Chemical"},{"id":"T32116","span":{"begin":370,"end":378},"obj":"Chemical"},{"id":"T64562","span":{"begin":541,"end":543},"obj":"Chemical"},{"id":"T5757","span":{"begin":580,"end":582},"obj":"Chemical"},{"id":"T9480","span":{"begin":595,"end":598},"obj":"Chemical"},{"id":"T12334","span":{"begin":806,"end":814},"obj":"Chemical"},{"id":"T12","span":{"begin":927,"end":935},"obj":"Chemical"},{"id":"T64066","span":{"begin":978,"end":981},"obj":"Chemical"},{"id":"T15","span":{"begin":1024,"end":1033},"obj":"Chemical"},{"id":"T80163","span":{"begin":1101,"end":1109},"obj":"Chemical"},{"id":"T11885","span":{"begin":1176,"end":1184},"obj":"Chemical"},{"id":"T19","span":{"begin":1226,"end":1228},"obj":"Chemical"},{"id":"T22795","span":{"begin":1363,"end":1370},"obj":"Chemical"},{"id":"T56524","span":{"begin":1445,"end":1453},"obj":"Chemical"},{"id":"T22","span":{"begin":1525,"end":1534},"obj":"Chemical"},{"id":"T54050","span":{"begin":1536,"end":1539},"obj":"Chemical"},{"id":"T24","span":{"begin":1628,"end":1637},"obj":"Chemical"},{"id":"T4899","span":{"begin":1647,"end":1656},"obj":"Chemical"},{"id":"T26","span":{"begin":1661,"end":1669},"obj":"Chemical"},{"id":"T553","span":{"begin":1697,"end":1705},"obj":"Chemical"},{"id":"T61869","span":{"begin":1736,"end":1746},"obj":"Chemical"},{"id":"T41653","span":{"begin":1781,"end":1791},"obj":"Chemical"},{"id":"T31","span":{"begin":1860,"end":1869},"obj":"Chemical"},{"id":"T4654","span":{"begin":1909,"end":1917},"obj":"Chemical"},{"id":"T47424","span":{"begin":1982,"end":1992},"obj":"Chemical"},{"id":"T96207","span":{"begin":1994,"end":2004},"obj":"Chemical"},{"id":"T9447","span":{"begin":2009,"end":2017},"obj":"Chemical"},{"id":"T14570","span":{"begin":2081,"end":2083},"obj":"Chemical"},{"id":"T32988","span":{"begin":2085,"end":2087},"obj":"Chemical"},{"id":"T39702","span":{"begin":2101,"end":2109},"obj":"Chemical"},{"id":"T69404","span":{"begin":2147,"end":2155},"obj":"Chemical"},{"id":"T44","span":{"begin":2235,"end":2243},"obj":"Chemical"},{"id":"T46","span":{"begin":2306,"end":2311},"obj":"Chemical"},{"id":"T68016","span":{"begin":2314,"end":2321},"obj":"Chemical"},{"id":"T48","span":{"begin":2324,"end":2330},"obj":"Chemical"},{"id":"T50651","span":{"begin":2352,"end":2356},"obj":"Chemical"},{"id":"T52793","span":{"begin":2376,"end":2400},"obj":"Chemical"},{"id":"T29928","span":{"begin":2378,"end":2384},"obj":"Chemical"},{"id":"T65599","span":{"begin":2385,"end":2400},"obj":"Chemical"},{"id":"T6522","span":{"begin":2387,"end":2400},"obj":"Chemical"},{"id":"T67050","span":{"begin":2396,"end":2400},"obj":"Chemical"},{"id":"T85819","span":{"begin":2449,"end":2451},"obj":"Chemical"},{"id":"T58","span":{"begin":2492,"end":2494},"obj":"Chemical"},{"id":"T79856","span":{"begin":2546,"end":2549},"obj":"Chemical"},{"id":"T12888","span":{"begin":2599,"end":2601},"obj":"Chemical"},{"id":"T38030","span":{"begin":2607,"end":2609},"obj":"Chemical"},{"id":"T87801","span":{"begin":2721,"end":2729},"obj":"Chemical"},{"id":"T3614","span":{"begin":2768,"end":2770},"obj":"Chemical"},{"id":"T82906","span":{"begin":2790,"end":2797},"obj":"Chemical"},{"id":"T40213","span":{"begin":2854,"end":2863},"obj":"Chemical"},{"id":"T28773","span":{"begin":2865,"end":2868},"obj":"Chemical"},{"id":"T21964","span":{"begin":2903,"end":2911},"obj":"Chemical"},{"id":"T33921","span":{"begin":3006,"end":3013},"obj":"Chemical"},{"id":"T3867","span":{"begin":3705,"end":3720},"obj":"Chemical"},{"id":"T74","span":{"begin":3773,"end":3775},"obj":"Chemical"},{"id":"T37470","span":{"begin":3845,"end":3859},"obj":"Chemical"}],"attributes":[{"id":"A29017","pred":"chebi_id","subj":"T19918","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A28033","pred":"chebi_id","subj":"T19918","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A56782","pred":"chebi_id","subj":"T97552","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A96099","pred":"chebi_id","subj":"T32116","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A93790","pred":"chebi_id","subj":"T32116","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A88457","pred":"chebi_id","subj":"T64562","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A13351","pred":"chebi_id","subj":"T5757","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A21099","pred":"chebi_id","subj":"T9480","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"},{"id":"A72149","pred":"chebi_id","subj":"T9480","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"},{"id":"A67395","pred":"chebi_id","subj":"T12334","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A37698","pred":"chebi_id","subj":"T12334","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A47292","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A11080","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A14742","pred":"chebi_id","subj":"T64066","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A56038","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_8925"},{"id":"A1384","pred":"chebi_id","subj":"T80163","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A59922","pred":"chebi_id","subj":"T80163","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A32459","pred":"chebi_id","subj":"T11885","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A34933","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_28984"},{"id":"A68913","pred":"chebi_id","subj":"T22795","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A26049","pred":"chebi_id","subj":"T56524","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A81340","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_8925"},{"id":"A74573","pred":"chebi_id","subj":"T54050","obj":"http://purl.obolibrary.org/obo/CHEBI_8925"},{"id":"A81421","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_8925"},{"id":"A8650","pred":"chebi_id","subj":"T4899","obj":"http://purl.obolibrary.org/obo/CHEBI_8925"},{"id":"A11430","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_15361"},{"id":"A93822","pred":"chebi_id","subj":"T553","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A79081","pred":"chebi_id","subj":"T553","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A4161","pred":"chebi_id","subj":"T61869","obj":"http://purl.obolibrary.org/obo/CHEBI_7575"},{"id":"A26912","pred":"chebi_id","subj":"T41653","obj":"http://purl.obolibrary.org/obo/CHEBI_4317"},{"id":"A90192","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_8925"},{"id":"A38269","pred":"chebi_id","subj":"T4654","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A80836","pred":"chebi_id","subj":"T4654","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A52381","pred":"chebi_id","subj":"T47424","obj":"http://purl.obolibrary.org/obo/CHEBI_7575"},{"id":"A15680","pred":"chebi_id","subj":"T96207","obj":"http://purl.obolibrary.org/obo/CHEBI_4317"},{"id":"A86907","pred":"chebi_id","subj":"T9447","obj":"http://purl.obolibrary.org/obo/CHEBI_15361"},{"id":"A27922","pred":"chebi_id","subj":"T14570","obj":"http://purl.obolibrary.org/obo/CHEBI_55460"},{"id":"A14500","pred":"chebi_id","subj":"T14570","obj":"http://purl.obolibrary.org/obo/CHEBI_74861"},{"id":"A81486","pred":"chebi_id","subj":"T32988","obj":"http://purl.obolibrary.org/obo/CHEBI_55460"},{"id":"A17965","pred":"chebi_id","subj":"T32988","obj":"http://purl.obolibrary.org/obo/CHEBI_74861"},{"id":"A88529","pred":"chebi_id","subj":"T39702","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A10551","pred":"chebi_id","subj":"T69404","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A99903","pred":"chebi_id","subj":"T69404","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A16112","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A54549","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A86165","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A34785","pred":"chebi_id","subj":"T68016","obj":"http://purl.obolibrary.org/obo/CHEBI_43176"},{"id":"A57821","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A67272","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A90758","pred":"chebi_id","subj":"T50651","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A12309","pred":"chebi_id","subj":"T52793","obj":"http://purl.obolibrary.org/obo/CHEBI_31882"},{"id":"A87712","pred":"chebi_id","subj":"T29928","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A89905","pred":"chebi_id","subj":"T29928","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A79281","pred":"chebi_id","subj":"T65599","obj":"http://purl.obolibrary.org/obo/CHEBI_17364"},{"id":"A88755","pred":"chebi_id","subj":"T6522","obj":"http://purl.obolibrary.org/obo/CHEBI_22660"},{"id":"A71303","pred":"chebi_id","subj":"T67050","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A78718","pred":"chebi_id","subj":"T85819","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A22860","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A57290","pred":"chebi_id","subj":"T79856","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"},{"id":"A23527","pred":"chebi_id","subj":"T79856","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"},{"id":"A36730","pred":"chebi_id","subj":"T12888","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A38780","pred":"chebi_id","subj":"T38030","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A31631","pred":"chebi_id","subj":"T87801","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A57561","pred":"chebi_id","subj":"T87801","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A9116","pred":"chebi_id","subj":"T3614","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A62223","pred":"chebi_id","subj":"T82906","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A79628","pred":"chebi_id","subj":"T82906","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A90940","pred":"chebi_id","subj":"T40213","obj":"http://purl.obolibrary.org/obo/CHEBI_8925"},{"id":"A64637","pred":"chebi_id","subj":"T28773","obj":"http://purl.obolibrary.org/obo/CHEBI_8925"},{"id":"A8239","pred":"chebi_id","subj":"T21964","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A39229","pred":"chebi_id","subj":"T21964","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A88652","pred":"chebi_id","subj":"T33921","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A40751","pred":"chebi_id","subj":"T3867","obj":"http://purl.obolibrary.org/obo/CHEBI_6809"},{"id":"A77495","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A54785","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A5169","pred":"chebi_id","subj":"T37470","obj":"http://purl.obolibrary.org/obo/CHEBI_24261"},{"subj":"T19918","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T97552","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T32116","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T64562","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5757","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9480","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12334","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T64066","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T80163","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11885","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T22795","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T56524","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T54050","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4899","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T553","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T61869","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T41653","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4654","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T47424","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T96207","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9447","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T14570","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T32988","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T39702","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T69404","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T68016","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T50651","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T52793","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T29928","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T65599","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6522","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T67050","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T85819","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T79856","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12888","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38030","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T87801","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3614","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T82906","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40213","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T28773","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T21964","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T33921","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3867","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T37470","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1795","span":{"begin":11,"end":14},"obj":"Species"},{"id":"1839","span":{"begin":1536,"end":1539},"obj":"Gene"},{"id":"1840","span":{"begin":1572,"end":1575},"obj":"Gene"},{"id":"1841","span":{"begin":2139,"end":2142},"obj":"Gene"},{"id":"1842","span":{"begin":2424,"end":2427},"obj":"Gene"},{"id":"1843","span":{"begin":2865,"end":2868},"obj":"Gene"},{"id":"1844","span":{"begin":2932,"end":2935},"obj":"Gene"},{"id":"1845","span":{"begin":2713,"end":2716},"obj":"Gene"},{"id":"1846","span":{"begin":2227,"end":2230},"obj":"Gene"},{"id":"1847","span":{"begin":2089,"end":2092},"obj":"Gene"},{"id":"1848","span":{"begin":2056,"end":2059},"obj":"Gene"},{"id":"1849","span":{"begin":1901,"end":1904},"obj":"Gene"},{"id":"1850","span":{"begin":1689,"end":1692},"obj":"Gene"},{"id":"1851","span":{"begin":1497,"end":1500},"obj":"Gene"},{"id":"1852","span":{"begin":2133,"end":2138},"obj":"Species"},{"id":"1853","span":{"begin":1493,"end":1496},"obj":"Species"},{"id":"1854","span":{"begin":1445,"end":1453},"obj":"Chemical"},{"id":"1855","span":{"begin":1515,"end":1519},"obj":"Chemical"},{"id":"1856","span":{"begin":1525,"end":1534},"obj":"Chemical"},{"id":"1857","span":{"begin":1598,"end":1602},"obj":"Chemical"},{"id":"1858","span":{"begin":1628,"end":1637},"obj":"Chemical"},{"id":"1859","span":{"begin":1647,"end":1656},"obj":"Chemical"},{"id":"1860","span":{"begin":1661,"end":1669},"obj":"Chemical"},{"id":"1861","span":{"begin":1697,"end":1705},"obj":"Chemical"},{"id":"1862","span":{"begin":1728,"end":1732},"obj":"Chemical"},{"id":"1863","span":{"begin":1736,"end":1746},"obj":"Chemical"},{"id":"1864","span":{"begin":1755,"end":1759},"obj":"Chemical"},{"id":"1865","span":{"begin":1781,"end":1791},"obj":"Chemical"},{"id":"1866","span":{"begin":1831,"end":1835},"obj":"Chemical"},{"id":"1867","span":{"begin":1860,"end":1869},"obj":"Chemical"},{"id":"1868","span":{"begin":1909,"end":1917},"obj":"Chemical"},{"id":"1869","span":{"begin":1940,"end":1944},"obj":"Chemical"},{"id":"1870","span":{"begin":1982,"end":1992},"obj":"Chemical"},{"id":"1871","span":{"begin":1994,"end":2004},"obj":"Chemical"},{"id":"1872","span":{"begin":2009,"end":2017},"obj":"Chemical"},{"id":"1873","span":{"begin":2101,"end":2109},"obj":"Chemical"},{"id":"1874","span":{"begin":2147,"end":2155},"obj":"Chemical"},{"id":"1875","span":{"begin":2682,"end":2686},"obj":"Chemical"},{"id":"1876","span":{"begin":2721,"end":2729},"obj":"Chemical"},{"id":"1877","span":{"begin":2790,"end":2797},"obj":"Chemical"},{"id":"1878","span":{"begin":2854,"end":2863},"obj":"Chemical"},{"id":"1879","span":{"begin":2903,"end":2911},"obj":"Chemical"},{"id":"1880","span":{"begin":2976,"end":2980},"obj":"Chemical"},{"id":"1881","span":{"begin":2168,"end":2183},"obj":"Disease"},{"id":"1910","span":{"begin":383,"end":386},"obj":"Gene"},{"id":"1911","span":{"begin":425,"end":428},"obj":"Gene"},{"id":"1912","span":{"begin":481,"end":484},"obj":"Gene"},{"id":"1913","span":{"begin":752,"end":755},"obj":"Gene"},{"id":"1914","span":{"begin":843,"end":846},"obj":"Gene"},{"id":"1915","span":{"begin":877,"end":881},"obj":"Gene"},{"id":"1916","span":{"begin":948,"end":951},"obj":"Gene"},{"id":"1917","span":{"begin":1037,"end":1041},"obj":"Gene"},{"id":"1918","span":{"begin":1129,"end":1132},"obj":"Gene"},{"id":"1919","span":{"begin":1255,"end":1258},"obj":"Gene"},{"id":"1920","span":{"begin":164,"end":167},"obj":"Gene"},{"id":"1921","span":{"begin":856,"end":860},"obj":"Species"},{"id":"1922","span":{"begin":69,"end":72},"obj":"Species"},{"id":"1923","span":{"begin":160,"end":163},"obj":"Species"},{"id":"1924","span":{"begin":126,"end":134},"obj":"Chemical"},{"id":"1925","span":{"begin":370,"end":378},"obj":"Chemical"},{"id":"1926","span":{"begin":557,"end":561},"obj":"Chemical"},{"id":"1927","span":{"begin":595,"end":598},"obj":"Chemical"},{"id":"1928","span":{"begin":704,"end":712},"obj":"Chemical"},{"id":"1929","span":{"begin":806,"end":814},"obj":"Chemical"},{"id":"1930","span":{"begin":927,"end":935},"obj":"Chemical"},{"id":"1931","span":{"begin":1009,"end":1013},"obj":"Chemical"},{"id":"1932","span":{"begin":1024,"end":1033},"obj":"Chemical"},{"id":"1933","span":{"begin":1101,"end":1109},"obj":"Chemical"},{"id":"1934","span":{"begin":1299,"end":1303},"obj":"Chemical"},{"id":"1935","span":{"begin":81,"end":104},"obj":"Disease"},{"id":"1936","span":{"begin":203,"end":219},"obj":"Disease"},{"id":"1937","span":{"begin":437,"end":474},"obj":"Disease"},{"id":"1953","span":{"begin":3763,"end":3768},"obj":"Gene"},{"id":"1954","span":{"begin":3773,"end":3778},"obj":"Gene"},{"id":"1955","span":{"begin":3784,"end":3788},"obj":"Gene"},{"id":"1956","span":{"begin":3823,"end":3829},"obj":"Gene"},{"id":"1957","span":{"begin":3830,"end":3841},"obj":"Gene"},{"id":"1958","span":{"begin":3845,"end":3868},"obj":"Gene"},{"id":"1959","span":{"begin":3379,"end":3382},"obj":"Species"},{"id":"1960","span":{"begin":3561,"end":3564},"obj":"Species"},{"id":"1961","span":{"begin":3595,"end":3598},"obj":"Species"},{"id":"1962","span":{"begin":3705,"end":3720},"obj":"Chemical"},{"id":"1963","span":{"begin":3110,"end":3125},"obj":"Disease"},{"id":"1964","span":{"begin":3236,"end":3244},"obj":"Disease"},{"id":"1965","span":{"begin":3306,"end":3321},"obj":"Disease"},{"id":"1966","span":{"begin":3348,"end":3363},"obj":"Disease"},{"id":"1967","span":{"begin":3395,"end":3403},"obj":"Disease"}],"attributes":[{"id":"A1795","pred":"tao:has_database_id","subj":"1795","obj":"Tax:12721"},{"id":"A1839","pred":"tao:has_database_id","subj":"1839","obj":"Gene:6262"},{"id":"A1840","pred":"tao:has_database_id","subj":"1840","obj":"Gene:6898"},{"id":"A1841","pred":"tao:has_database_id","subj":"1841","obj":"Gene:6898"},{"id":"A1842","pred":"tao:has_database_id","subj":"1842","obj":"Gene:4988"},{"id":"A1843","pred":"tao:has_database_id","subj":"1843","obj":"Gene:6262"},{"id":"A1844","pred":"tao:has_database_id","subj":"1844","obj":"Gene:4988"},{"id":"A1845","pred":"tao:has_database_id","subj":"1845","obj":"Gene:6898"},{"id":"A1846","pred":"tao:has_database_id","subj":"1846","obj":"Gene:6898"},{"id":"A1847","pred":"tao:has_database_id","subj":"1847","obj":"Gene:6898"},{"id":"A1848","pred":"tao:has_database_id","subj":"1848","obj":"Gene:6898"},{"id":"A1849","pred":"tao:has_database_id","subj":"1849","obj":"Gene:6898"},{"id":"A1850","pred":"tao:has_database_id","subj":"1850","obj":"Gene:6898"},{"id":"A1851","pred":"tao:has_database_id","subj":"1851","obj":"Gene:6898"},{"id":"A1852","pred":"tao:has_database_id","subj":"1852","obj":"Tax:11676"},{"id":"A1853","pred":"tao:has_database_id","subj":"1853","obj":"Tax:12721"},{"id":"A1854","pred":"tao:has_database_id","subj":"1854","obj":"MESH:D009020"},{"id":"A1855","pred":"tao:has_database_id","subj":"1855","obj":"MESH:D000069285"},{"id":"A1856","pred":"tao:has_database_id","subj":"1856","obj":"MESH:D012433"},{"id":"A1857","pred":"tao:has_database_id","subj":"1857","obj":"MESH:D000069285"},{"id":"A1858","pred":"tao:has_database_id","subj":"1858","obj":"MESH:D012433"},{"id":"A1859","pred":"tao:has_database_id","subj":"1859","obj":"MESH:D012433"},{"id":"A1860","pred":"tao:has_database_id","subj":"1860","obj":"MESH:D019289"},{"id":"A1861","pred":"tao:has_database_id","subj":"1861","obj":"MESH:D009020"},{"id":"A1862","pred":"tao:has_database_id","subj":"1862","obj":"MESH:D000069285"},{"id":"A1863","pred":"tao:has_database_id","subj":"1863","obj":"MESH:D009553"},{"id":"A1864","pred":"tao:has_database_id","subj":"1864","obj":"MESH:D000069285"},{"id":"A1865","pred":"tao:has_database_id","subj":"1865","obj":"MESH:D003620"},{"id":"A1866","pred":"tao:has_database_id","subj":"1866","obj":"MESH:D000069285"},{"id":"A1867","pred":"tao:has_database_id","subj":"1867","obj":"MESH:D012433"},{"id":"A1868","pred":"tao:has_database_id","subj":"1868","obj":"MESH:D009020"},{"id":"A1869","pred":"tao:has_database_id","subj":"1869","obj":"MESH:D000069285"},{"id":"A1870","pred":"tao:has_database_id","subj":"1870","obj":"MESH:D009553"},{"id":"A1871","pred":"tao:has_database_id","subj":"1871","obj":"MESH:D003620"},{"id":"A1872","pred":"tao:has_database_id","subj":"1872","obj":"MESH:D019289"},{"id":"A1873","pred":"tao:has_database_id","subj":"1873","obj":"MESH:D009020"},{"id":"A1874","pred":"tao:has_database_id","subj":"1874","obj":"MESH:D009020"},{"id":"A1875","pred":"tao:has_database_id","subj":"1875","obj":"MESH:D000069285"},{"id":"A1876","pred":"tao:has_database_id","subj":"1876","obj":"MESH:D009020"},{"id":"A1877","pred":"tao:has_database_id","subj":"1877","obj":"MESH:D002118"},{"id":"A1878","pred":"tao:has_database_id","subj":"1878","obj":"MESH:D012433"},{"id":"A1879","pred":"tao:has_database_id","subj":"1879","obj":"MESH:D009020"},{"id":"A1880","pred":"tao:has_database_id","subj":"1880","obj":"MESH:D000069285"},{"id":"A1881","pred":"tao:has_database_id","subj":"1881","obj":"MESH:D009410"},{"id":"A1910","pred":"tao:has_database_id","subj":"1910","obj":"Gene:6898"},{"id":"A1911","pred":"tao:has_database_id","subj":"1911","obj":"Gene:6898"},{"id":"A1912","pred":"tao:has_database_id","subj":"1912","obj":"Gene:4988"},{"id":"A1913","pred":"tao:has_database_id","subj":"1913","obj":"Gene:18390"},{"id":"A1914","pred":"tao:has_database_id","subj":"1914","obj":"Gene:18390"},{"id":"A1915","pred":"tao:has_database_id","subj":"1915","obj":"Gene:21898"},{"id":"A1916","pred":"tao:has_database_id","subj":"1916","obj":"Gene:234724"},{"id":"A1917","pred":"tao:has_database_id","subj":"1917","obj":"Gene:6262"},{"id":"A1918","pred":"tao:has_database_id","subj":"1918","obj":"Gene:18390"},{"id":"A1919","pred":"tao:has_database_id","subj":"1919","obj":"Gene:18390"},{"id":"A1920","pred":"tao:has_database_id","subj":"1920","obj":"Gene:6898"},{"id":"A1921","pred":"tao:has_database_id","subj":"1921","obj":"Tax:10090"},{"id":"A1922","pred":"tao:has_database_id","subj":"1922","obj":"Tax:12721"},{"id":"A1923","pred":"tao:has_database_id","subj":"1923","obj":"Tax:12721"},{"id":"A1924","pred":"tao:has_database_id","subj":"1924","obj":"MESH:D009020"},{"id":"A1925","pred":"tao:has_database_id","subj":"1925","obj":"MESH:D009020"},{"id":"A1926","pred":"tao:has_database_id","subj":"1926","obj":"MESH:D000069285"},{"id":"A1927","pred":"tao:has_database_id","subj":"1927","obj":"MESH:D000255"},{"id":"A1928","pred":"tao:has_database_id","subj":"1928","obj":"MESH:D009020"},{"id":"A1929","pred":"tao:has_database_id","subj":"1929","obj":"MESH:D009020"},{"id":"A1930","pred":"tao:has_database_id","subj":"1930","obj":"MESH:D009020"},{"id":"A1931","pred":"tao:has_database_id","subj":"1931","obj":"MESH:D000069285"},{"id":"A1932","pred":"tao:has_database_id","subj":"1932","obj":"MESH:D012433"},{"id":"A1933","pred":"tao:has_database_id","subj":"1933","obj":"MESH:D009020"},{"id":"A1934","pred":"tao:has_database_id","subj":"1934","obj":"MESH:D000069285"},{"id":"A1935","pred":"tao:has_database_id","subj":"1935","obj":"MESH:D020258"},{"id":"A1936","pred":"tao:has_database_id","subj":"1936","obj":"MESH:D007635"},{"id":"A1937","pred":"tao:has_database_id","subj":"1937","obj":"MESH:D014647"},{"id":"A1953","pred":"tao:has_database_id","subj":"1953","obj":"Gene:7124"},{"id":"A1954","pred":"tao:has_database_id","subj":"1954","obj":"Gene:3552"},{"id":"A1955","pred":"tao:has_database_id","subj":"1955","obj":"Gene:7098"},{"id":"A1956","pred":"tao:has_database_id","subj":"1956","obj":"Gene:6376"},{"id":"A1957","pred":"tao:has_database_id","subj":"1957","obj":"Gene:6376"},{"id":"A1958","pred":"tao:has_database_id","subj":"1958","obj":"Gene:2908"},{"id":"A1959","pred":"tao:has_database_id","subj":"1959","obj":"Tax:12721"},{"id":"A1960","pred":"tao:has_database_id","subj":"1960","obj":"Tax:12721"},{"id":"A1961","pred":"tao:has_database_id","subj":"1961","obj":"Tax:12721"},{"id":"A1962","pred":"tao:has_database_id","subj":"1962","obj":"MESH:D008694"},{"id":"A1963","pred":"tao:has_database_id","subj":"1963","obj":"MESH:D009410"},{"id":"A1964","pred":"tao:has_database_id","subj":"1964","obj":"MESH:D007239"},{"id":"A1965","pred":"tao:has_database_id","subj":"1965","obj":"MESH:D009410"},{"id":"A1966","pred":"tao:has_database_id","subj":"1966","obj":"MESH:D009410"},{"id":"A1967","pred":"tao:has_database_id","subj":"1967","obj":"MESH:D007239"},{"subj":"1795","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1839","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1840","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1841","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1842","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1843","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1844","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1845","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1846","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1847","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1848","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1849","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1850","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1851","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1852","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1853","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1854","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1855","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1856","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1857","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1858","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1859","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1860","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1861","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1862","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1863","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1864","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1865","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1866","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1867","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1868","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1869","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1870","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1871","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1872","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1873","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1874","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1875","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1876","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1877","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1878","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1879","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1880","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1881","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1910","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1911","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1912","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1913","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1914","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1915","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1916","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1917","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1918","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1919","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1920","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1921","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1922","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1923","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1924","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1925","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1926","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1927","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1928","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1929","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1930","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1931","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1932","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1933","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1934","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1935","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1936","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1937","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1953","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1954","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1955","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1956","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1957","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1958","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1959","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1960","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1961","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1962","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1963","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1964","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1965","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1966","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1967","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T85","span":{"begin":183,"end":198},"obj":"http://purl.obolibrary.org/obo/GO_0050801"},{"id":"T86","span":{"begin":187,"end":198},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T87","span":{"begin":412,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T88","span":{"begin":978,"end":993},"obj":"http://purl.obolibrary.org/obo/GO_0050801"},{"id":"T89","span":{"begin":982,"end":993},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T90","span":{"begin":2689,"end":2700},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T91","span":{"begin":2790,"end":2810},"obj":"http://purl.obolibrary.org/obo/GO_0051209"},{"id":"T92","span":{"begin":3845,"end":3879},"obj":"http://purl.obolibrary.org/obo/GO_0004883"},{"id":"T93","span":{"begin":3845,"end":3879},"obj":"http://purl.obolibrary.org/obo/GO_0004879"}],"attributes":[{"subj":"T85","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T717","span":{"begin":0,"end":47},"obj":"Sentence"},{"id":"T718","span":{"begin":48,"end":352},"obj":"Sentence"},{"id":"T719","span":{"begin":353,"end":360},"obj":"Sentence"},{"id":"T720","span":{"begin":361,"end":682},"obj":"Sentence"},{"id":"T721","span":{"begin":683,"end":690},"obj":"Sentence"},{"id":"T722","span":{"begin":691,"end":909},"obj":"Sentence"},{"id":"T723","span":{"begin":910,"end":917},"obj":"Sentence"},{"id":"T724","span":{"begin":918,"end":1074},"obj":"Sentence"},{"id":"T725","span":{"begin":1075,"end":1091},"obj":"Sentence"},{"id":"T726","span":{"begin":1092,"end":1199},"obj":"Sentence"},{"id":"T727","span":{"begin":1200,"end":1219},"obj":"Sentence"},{"id":"T728","span":{"begin":1220,"end":1333},"obj":"Sentence"},{"id":"T729","span":{"begin":1334,"end":1394},"obj":"Sentence"},{"id":"T730","span":{"begin":1395,"end":1437},"obj":"Sentence"},{"id":"T731","span":{"begin":1438,"end":1735},"obj":"Sentence"},{"id":"T732","span":{"begin":1736,"end":2088},"obj":"Sentence"},{"id":"T733","span":{"begin":2089,"end":2217},"obj":"Sentence"},{"id":"T734","span":{"begin":2218,"end":2663},"obj":"Sentence"},{"id":"T735","span":{"begin":2664,"end":3095},"obj":"Sentence"},{"id":"T736","span":{"begin":3096,"end":3148},"obj":"Sentence"},{"id":"T737","span":{"begin":3149,"end":3347},"obj":"Sentence"},{"id":"T738","span":{"begin":3348,"end":3439},"obj":"Sentence"},{"id":"T739","span":{"begin":3440,"end":3446},"obj":"Sentence"},{"id":"T740","span":{"begin":3447,"end":3905},"obj":"Sentence"},{"id":"T741","span":{"begin":3906,"end":3918},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T717","pred":"source","obj":"LitCovid-sentences"},{"subj":"T718","pred":"source","obj":"LitCovid-sentences"},{"subj":"T719","pred":"source","obj":"LitCovid-sentences"},{"subj":"T720","pred":"source","obj":"LitCovid-sentences"},{"subj":"T721","pred":"source","obj":"LitCovid-sentences"},{"subj":"T722","pred":"source","obj":"LitCovid-sentences"},{"subj":"T723","pred":"source","obj":"LitCovid-sentences"},{"subj":"T724","pred":"source","obj":"LitCovid-sentences"},{"subj":"T725","pred":"source","obj":"LitCovid-sentences"},{"subj":"T726","pred":"source","obj":"LitCovid-sentences"},{"subj":"T727","pred":"source","obj":"LitCovid-sentences"},{"subj":"T728","pred":"source","obj":"LitCovid-sentences"},{"subj":"T729","pred":"source","obj":"LitCovid-sentences"},{"subj":"T730","pred":"source","obj":"LitCovid-sentences"},{"subj":"T731","pred":"source","obj":"LitCovid-sentences"},{"subj":"T732","pred":"source","obj":"LitCovid-sentences"},{"subj":"T733","pred":"source","obj":"LitCovid-sentences"},{"subj":"T734","pred":"source","obj":"LitCovid-sentences"},{"subj":"T735","pred":"source","obj":"LitCovid-sentences"},{"subj":"T736","pred":"source","obj":"LitCovid-sentences"},{"subj":"T737","pred":"source","obj":"LitCovid-sentences"},{"subj":"T738","pred":"source","obj":"LitCovid-sentences"},{"subj":"T739","pred":"source","obj":"LitCovid-sentences"},{"subj":"T740","pred":"source","obj":"LitCovid-sentences"},{"subj":"T741","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32876803-269396-62958101","span":{"begin":1200,"end":1204},"obj":"269396"},{"id":"32876803-7931552-62958102","span":{"begin":1220,"end":1224},"obj":"7931552"},{"id":"32876803-22020140-62958103","span":{"begin":1248,"end":1252},"obj":"22020140"},{"id":"32876803-31887215-62958104","span":{"begin":3440,"end":3444},"obj":"31887215"},{"id":"32876803-28166799-62958105","span":{"begin":3906,"end":3910},"obj":"28166799"},{"id":"32876803-31887215-62958106","span":{"begin":3912,"end":3916},"obj":"31887215"}],"attributes":[{"subj":"32876803-269396-62958101","pred":"source","obj":"2_test"},{"subj":"32876803-7931552-62958102","pred":"source","obj":"2_test"},{"subj":"32876803-22020140-62958103","pred":"source","obj":"2_test"},{"subj":"32876803-31887215-62958104","pred":"source","obj":"2_test"},{"subj":"32876803-28166799-62958105","pred":"source","obj":"2_test"},{"subj":"32876803-31887215-62958106","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#b393ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#93ec99"},{"id":"LitCovid-PD-CLO","color":"#ec93a6"},{"id":"LitCovid-PD-CHEBI","color":"#93c0ec"},{"id":"LitCovid-PubTator","color":"#daec93"},{"id":"LitCovid-PD-GO-BP","color":"#e493ec"},{"id":"LitCovid-sentences","color":"#93ecca"},{"id":"2_test","color":"#ecb093"}]}]}}