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PMC:7463108 / 44875-47302 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T445 19-22 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T446 33-36 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T447 127-130 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T448 224-255 Body_part denotes glial fibrillary acidic protein http://purl.org/sig/ont/fma/fma63860
T449 257-261 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T451 278-288 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T452 514-517 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T453 556-560 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T455 587-598 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T456 599-608 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T457 867-877 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T458 885-896 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T459 897-906 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T460 1184-1195 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T461 1196-1205 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T462 1346-1350 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T464 1366-1376 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T465 1518-1521 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T466 1532-1535 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T467 1640-1650 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T468 1698-1707 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T469 1708-1719 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T470 1917-1927 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T471 1994-2005 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T472 2006-2015 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T473 2158-2161 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T474 2168-2171 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T95 33-36 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T96 434-439 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T97 1532-1535 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T123 37-49 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T124 1536-1548 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T125 1734-1746 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T546 33-36 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T547 33-36 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T548 33-36 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T549 177-186 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T550 278-288 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T551 346-347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T552 348-349 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T553 445-446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T554 447-448 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T555 580-585 http://purl.obolibrary.org/obo/CLO_0002980 denotes F4/80
T556 599-608 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T557 867-877 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T558 897-906 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T559 907-914 http://purl.obolibrary.org/obo/CLO_0003797 denotes (h) [*p
T560 907-914 http://purl.obolibrary.org/obo/PR_000008725 denotes (h) [*p
T561 907-914 http://purl.obolibrary.org/obo/UBERON_0000007 denotes (h) [*p
T562 1196-1205 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T563 1366-1376 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T564 1532-1535 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T565 1532-1535 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T566 1532-1535 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T567 1640-1650 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T568 1668-1678 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T569 1698-1707 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T570 2006-2015 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T571 2274-2278 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T572 2282-2283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T461 248-255 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T462 526-534 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T464 786-794 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T466 1006-1014 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T468 1228-1236 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1627 74-78 Gene denotes CCL5 Gene:6352
1628 102-106 Gene denotes CCL2 Gene:6347
1629 224-255 Gene denotes glial fibrillary acidic protein Gene:14580
1630 257-261 Gene denotes GFAP Gene:14580
1631 323-327 Gene denotes CCR2 Gene:12772
1632 360-364 Gene denotes CCL2 Gene:20296
1633 380-397 Gene denotes μ-opioid receptor Gene:18390
1634 399-402 Gene denotes MOR Gene:18390
1635 472-476 Gene denotes CCR2 Gene:729230
1636 520-523 Gene denotes Tat Gene:6898
1637 556-560 Gene denotes GFAP Gene:2670
1638 687-690 Gene denotes Tat Gene:234724
1639 780-783 Gene denotes Tat Gene:234724
1640 847-851 Gene denotes CCL2 Gene:20296
1641 955-959 Gene denotes CCL5 Gene:20304
1642 997-1000 Gene denotes Tat Gene:234724
1643 1103-1107 Gene denotes CCL5 Gene:20304
1644 1144-1148 Gene denotes CCL2 Gene:20296
1645 1220-1223 Gene denotes Tat Gene:234724
1646 1269-1273 Gene denotes CCL5 Gene:20304
1647 1318-1322 Gene denotes CCL5 Gene:20304
1648 1346-1350 Gene denotes GFAP Gene:14580
1649 1573-1577 Gene denotes CCL5 Gene:6352
1650 1593-1597 Gene denotes CCR5 Gene:1234
1651 1621-1625 Gene denotes CCL2 Gene:6347
1652 2231-2235 Gene denotes BDNF Gene:627
1653 2243-2247 Gene denotes BDNF Gene:627
1654 2249-2254 Gene denotes mBDNF Gene:12064
1655 1406-1409 Gene denotes Tat Gene:234724
1656 2408-2412 Gene denotes Hage Gene:55510
1657 2334-2338 Gene denotes Hage Gene:55510
1658 1479-1483 Gene denotes Hage Gene:55510
1659 1298-1302 Gene denotes Hage Gene:55510
1660 741-745 Gene denotes Hage Gene:55510
1661 19-24 Species denotes HIV-1 Tax:11676
1662 301-305 Species denotes mice Tax:10090
1663 514-519 Species denotes HIV-1 Tax:11676
1664 641-645 Species denotes mice Tax:10090
1665 726-730 Species denotes mice Tax:10090
1666 774-778 Species denotes mice Tax:10090
1667 965-969 Species denotes mice Tax:10090
1668 1033-1037 Species denotes mice Tax:10090
1669 1087-1091 Species denotes mice Tax:10090
1670 1113-1117 Species denotes mice Tax:10090
1671 1283-1287 Species denotes mice Tax:10090
1672 1458-1462 Species denotes mice Tax:10090
1673 1518-1523 Species denotes HIV-1 Tax:11676
1674 127-130 Species denotes HIV Tax:12721
1675 526-534 Chemical denotes morphine MESH:D009020
1676 33-49 Disease denotes CNS inflammation MESH:D007249
1677 1532-1548 Disease denotes CNS inflammation MESH:D007249
1678 1734-1746 Disease denotes inflammation MESH:D007249
1679 2158-2171 Disease denotes HIV-1 Tat/HIV MESH:D015658

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T75 37-49 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T76 177-195 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascades
T77 177-186 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T78 1536-1548 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T79 1621-1636 http://purl.obolibrary.org/obo/GO_0071605 denotes CCL2 production
T80 1734-1746 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T687 197-471 Sentence denotes Subpopulations of striatal glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in wildtype mice normally express CCR2 immunoreactivity (a-b; arrows), CCL2 (c; arrow), or μ-opioid receptor (MOR) (d; arrows) immunoreactivity (scale bars a-b = 25 μm; c-d = 15 μm).
T688 472-752 Sentence denotes CCR2 deletion (−/−) significantly reduces HIV-1 Tat ± morphine-induced increases in GFAP+ astroglia (e) and F4/80+ macrophages/microglia (f) compared to wild type (+/+) mice at sites near (300 ± 100 μm) the site of Tat injection (*p < 0.05 vs. wild type mice) (see, El-Hage et al.
T689 753-760 Sentence denotes 2006a).
T690 761-1309 Sentence denotes In wild-type mice, Tat ± morphine administration markedly increases the proportion of CCL2 immunoreactive astrocytes (g) or macrophages/microglia (h) [*p < 0.05 vs. other groups in wild-type or CCL5(−/−) mice; bp < 0.05 vs. vehicle- or Tat plus morphine-treated wild-type mice; #p < 0.05 vs. equivalent treatment in wild-type mice], while in CCL5 null mice, significant increases in CCL2 immunoreactivity were only seen in macrophages/microglia co-exposed to Tat and morphine (§p < 0.05 vs. vehicle injected CCL5 knockout mice) (see, El-Hage et al.
T691 1310-1317 Sentence denotes 2008a).
T692 1318-1490 Sentence denotes CCL5 expression in striatal GFAP-immunoreactive astrocytes (arrows) increases following Tat injections (i, j) compared to wild-type control mice (not shown) (El-Hage et al.
T693 1491-1498 Sentence denotes 2008a).
T694 1499-1751 Sentence denotes Opioids exacerbate HIV-1-induced CNS inflammation, in part, by increasing CCL5 and augmenting CCR5-dependent increases in CCL2 production by astrocytes resulting in the activation and recruitment of microglia/macrophages and spiraling inflammation (k).
T695 1752-1857 Sentence denotes Additional factors likely mediate the proinflammatory cascade, but these are less well substantiated (?).
T696 1858-2273 Sentence denotes Moreover, autocrine and reciprocal paracrine (astroglial ↔ macrophage/microglial) intercellular, feedback amplification mechanisms from macrophages/microglia are likely to be operative (dashed red arrow) (also see, Kang and Hebert 2011) and occur elsewhere within the cascade (not shown); effects of HIV-1 Tat/HIV, red arrows; sites of opioid convergence, blue arrows; pro-BDNF:mature BDNF (mBDNF) ratio (Kim et al.
T697 2274-2427 Sentence denotes 2018). (a-f) Modified and reprinted with permission from El-Hage et al. (2006a). (g-k) Modified and reprinted with permission from El-Hage et al. (2008a)

2_test

Id Subject Object Predicate Lexical cue
32876803-21234816-62958096 2089-2093 21234816 denotes 2011