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PMC:7463108 / 44868-47302 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T445 26-29 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T446 40-43 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T447 134-137 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T448 231-262 Body_part denotes glial fibrillary acidic protein http://purl.org/sig/ont/fma/fma63860
T449 264-268 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T451 285-295 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T452 521-524 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T453 563-567 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T455 594-605 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T456 606-615 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T457 874-884 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T458 892-903 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T459 904-913 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T460 1191-1202 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T461 1203-1212 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T462 1353-1357 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T464 1373-1383 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T465 1525-1528 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T466 1539-1542 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T467 1647-1657 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T468 1705-1714 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T469 1715-1726 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T470 1924-1934 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T471 2001-2012 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T472 2013-2022 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T473 2165-2168 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T474 2175-2178 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T95 40-43 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T96 441-446 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T97 1539-1542 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T123 44-56 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T124 1543-1555 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T125 1741-1753 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T546 40-43 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T547 40-43 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T548 40-43 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T549 184-193 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T550 285-295 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T551 353-354 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T552 355-356 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T553 452-453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T554 454-455 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T555 587-592 http://purl.obolibrary.org/obo/CLO_0002980 denotes F4/80
T556 606-615 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T557 874-884 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T558 904-913 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T559 914-921 http://purl.obolibrary.org/obo/CLO_0003797 denotes (h) [*p
T560 914-921 http://purl.obolibrary.org/obo/PR_000008725 denotes (h) [*p
T561 914-921 http://purl.obolibrary.org/obo/UBERON_0000007 denotes (h) [*p
T562 1203-1212 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T563 1373-1383 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T564 1539-1542 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T565 1539-1542 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T566 1539-1542 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T567 1647-1657 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T568 1675-1685 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T569 1705-1714 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T570 2013-2022 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T571 2281-2285 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T572 2289-2290 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T461 255-262 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T462 533-541 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T464 793-801 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T466 1013-1021 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T468 1235-1243 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1627 81-85 Gene denotes CCL5 Gene:6352
1628 109-113 Gene denotes CCL2 Gene:6347
1629 231-262 Gene denotes glial fibrillary acidic protein Gene:14580
1630 264-268 Gene denotes GFAP Gene:14580
1631 330-334 Gene denotes CCR2 Gene:12772
1632 367-371 Gene denotes CCL2 Gene:20296
1633 387-404 Gene denotes μ-opioid receptor Gene:18390
1634 406-409 Gene denotes MOR Gene:18390
1635 479-483 Gene denotes CCR2 Gene:729230
1636 527-530 Gene denotes Tat Gene:6898
1637 563-567 Gene denotes GFAP Gene:2670
1638 694-697 Gene denotes Tat Gene:234724
1639 787-790 Gene denotes Tat Gene:234724
1640 854-858 Gene denotes CCL2 Gene:20296
1641 962-966 Gene denotes CCL5 Gene:20304
1642 1004-1007 Gene denotes Tat Gene:234724
1643 1110-1114 Gene denotes CCL5 Gene:20304
1644 1151-1155 Gene denotes CCL2 Gene:20296
1645 1227-1230 Gene denotes Tat Gene:234724
1646 1276-1280 Gene denotes CCL5 Gene:20304
1647 1325-1329 Gene denotes CCL5 Gene:20304
1648 1353-1357 Gene denotes GFAP Gene:14580
1649 1580-1584 Gene denotes CCL5 Gene:6352
1650 1600-1604 Gene denotes CCR5 Gene:1234
1651 1628-1632 Gene denotes CCL2 Gene:6347
1652 2238-2242 Gene denotes BDNF Gene:627
1653 2250-2254 Gene denotes BDNF Gene:627
1654 2256-2261 Gene denotes mBDNF Gene:12064
1655 1413-1416 Gene denotes Tat Gene:234724
1656 2415-2419 Gene denotes Hage Gene:55510
1657 2341-2345 Gene denotes Hage Gene:55510
1658 1486-1490 Gene denotes Hage Gene:55510
1659 1305-1309 Gene denotes Hage Gene:55510
1660 748-752 Gene denotes Hage Gene:55510
1661 26-31 Species denotes HIV-1 Tax:11676
1662 308-312 Species denotes mice Tax:10090
1663 521-526 Species denotes HIV-1 Tax:11676
1664 648-652 Species denotes mice Tax:10090
1665 733-737 Species denotes mice Tax:10090
1666 781-785 Species denotes mice Tax:10090
1667 972-976 Species denotes mice Tax:10090
1668 1040-1044 Species denotes mice Tax:10090
1669 1094-1098 Species denotes mice Tax:10090
1670 1120-1124 Species denotes mice Tax:10090
1671 1290-1294 Species denotes mice Tax:10090
1672 1465-1469 Species denotes mice Tax:10090
1673 1525-1530 Species denotes HIV-1 Tax:11676
1674 134-137 Species denotes HIV Tax:12721
1675 533-541 Chemical denotes morphine MESH:D009020
1676 40-56 Disease denotes CNS inflammation MESH:D007249
1677 1539-1555 Disease denotes CNS inflammation MESH:D007249
1678 1741-1753 Disease denotes inflammation MESH:D007249
1679 2165-2178 Disease denotes HIV-1 Tat/HIV MESH:D015658

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T75 44-56 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T76 184-202 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascades
T77 184-193 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T78 1543-1555 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T79 1628-1643 http://purl.obolibrary.org/obo/GO_0071605 denotes CCL2 production
T80 1741-1753 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T686 0-203 Sentence denotes Fig. 1 Opioids exacerbate HIV-1-induced CNS inflammation, in part, by augmenting CCL5-dependent increases in CCL2—key sites of opioid-HIV convergent interactions in glial inflammatory signaling cascades.
T687 204-478 Sentence denotes Subpopulations of striatal glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in wildtype mice normally express CCR2 immunoreactivity (a-b; arrows), CCL2 (c; arrow), or μ-opioid receptor (MOR) (d; arrows) immunoreactivity (scale bars a-b = 25 μm; c-d = 15 μm).
T688 479-759 Sentence denotes CCR2 deletion (−/−) significantly reduces HIV-1 Tat ± morphine-induced increases in GFAP+ astroglia (e) and F4/80+ macrophages/microglia (f) compared to wild type (+/+) mice at sites near (300 ± 100 μm) the site of Tat injection (*p < 0.05 vs. wild type mice) (see, El-Hage et al.
T689 760-767 Sentence denotes 2006a).
T690 768-1316 Sentence denotes In wild-type mice, Tat ± morphine administration markedly increases the proportion of CCL2 immunoreactive astrocytes (g) or macrophages/microglia (h) [*p < 0.05 vs. other groups in wild-type or CCL5(−/−) mice; bp < 0.05 vs. vehicle- or Tat plus morphine-treated wild-type mice; #p < 0.05 vs. equivalent treatment in wild-type mice], while in CCL5 null mice, significant increases in CCL2 immunoreactivity were only seen in macrophages/microglia co-exposed to Tat and morphine (§p < 0.05 vs. vehicle injected CCL5 knockout mice) (see, El-Hage et al.
T691 1317-1324 Sentence denotes 2008a).
T692 1325-1497 Sentence denotes CCL5 expression in striatal GFAP-immunoreactive astrocytes (arrows) increases following Tat injections (i, j) compared to wild-type control mice (not shown) (El-Hage et al.
T693 1498-1505 Sentence denotes 2008a).
T694 1506-1758 Sentence denotes Opioids exacerbate HIV-1-induced CNS inflammation, in part, by increasing CCL5 and augmenting CCR5-dependent increases in CCL2 production by astrocytes resulting in the activation and recruitment of microglia/macrophages and spiraling inflammation (k).
T695 1759-1864 Sentence denotes Additional factors likely mediate the proinflammatory cascade, but these are less well substantiated (?).
T696 1865-2280 Sentence denotes Moreover, autocrine and reciprocal paracrine (astroglial ↔ macrophage/microglial) intercellular, feedback amplification mechanisms from macrophages/microglia are likely to be operative (dashed red arrow) (also see, Kang and Hebert 2011) and occur elsewhere within the cascade (not shown); effects of HIV-1 Tat/HIV, red arrows; sites of opioid convergence, blue arrows; pro-BDNF:mature BDNF (mBDNF) ratio (Kim et al.
T697 2281-2434 Sentence denotes 2018). (a-f) Modified and reprinted with permission from El-Hage et al. (2006a). (g-k) Modified and reprinted with permission from El-Hage et al. (2008a)

2_test

Id Subject Object Predicate Lexical cue
32876803-21234816-62958096 2096-2100 21234816 denotes 2011