PMC:7463108 / 44803-45218 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"L5, and IL-6 transcription in astrocytes (El-Hage et al. 2008b).\nFig. 1 Opioids exacerbate HIV-1-induced CNS inflammation, in part, by augmenting CCL5-dependent increases in CCL2—key sites of opioid-HIV convergent interactions in glial inflammatory signaling cascades. Subpopulations of striatal glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in wildtype mice normally express CCR2 immunoreactivit","divisions":[{"label":"label","span":{"begin":65,"end":71}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T444","span":{"begin":30,"end":40},"obj":"Body_part"},{"id":"T445","span":{"begin":91,"end":94},"obj":"Body_part"},{"id":"T446","span":{"begin":105,"end":108},"obj":"Body_part"},{"id":"T447","span":{"begin":199,"end":202},"obj":"Body_part"},{"id":"T448","span":{"begin":296,"end":327},"obj":"Body_part"},{"id":"T449","span":{"begin":329,"end":333},"obj":"Body_part"},{"id":"T451","span":{"begin":350,"end":360},"obj":"Body_part"}],"attributes":[{"id":"A444","pred":"fma_id","subj":"T444","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A445","pred":"fma_id","subj":"T445","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A446","pred":"fma_id","subj":"T446","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A447","pred":"fma_id","subj":"T447","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A448","pred":"fma_id","subj":"T448","obj":"http://purl.org/sig/ont/fma/fma63860"},{"id":"A449","pred":"fma_id","subj":"T449","obj":"http://purl.org/sig/ont/fma/fma67326"},{"id":"A450","pred":"fma_id","subj":"T449","obj":"http://purl.org/sig/ont/fma/fma63860"},{"id":"A451","pred":"fma_id","subj":"T451","obj":"http://purl.org/sig/ont/fma/fma54537"},{"subj":"T444","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T445","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T446","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T447","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T448","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T449","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T451","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T95","span":{"begin":105,"end":108},"obj":"Body_part"}],"attributes":[{"id":"A95","pred":"uberon_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T123","span":{"begin":109,"end":121},"obj":"Disease"}],"attributes":[{"id":"A123","pred":"mondo_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T545","span":{"begin":30,"end":40},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T546","span":{"begin":105,"end":108},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T547","span":{"begin":105,"end":108},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T548","span":{"begin":105,"end":108},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T549","span":{"begin":249,"end":258},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T550","span":{"begin":350,"end":360},"obj":"http://purl.obolibrary.org/obo/CL_0000127"}],"attributes":[{"subj":"T545","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T546","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T547","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T548","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T549","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T550","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T459","span":{"begin":8,"end":10},"obj":"Chemical"},{"id":"T461","span":{"begin":320,"end":327},"obj":"Chemical"}],"attributes":[{"id":"A459","pred":"chebi_id","subj":"T459","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A460","pred":"chebi_id","subj":"T459","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A461","pred":"chebi_id","subj":"T461","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T459","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T461","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1627","span":{"begin":146,"end":150},"obj":"Gene"},{"id":"1628","span":{"begin":174,"end":178},"obj":"Gene"},{"id":"1629","span":{"begin":296,"end":327},"obj":"Gene"},{"id":"1630","span":{"begin":329,"end":333},"obj":"Gene"},{"id":"1631","span":{"begin":395,"end":399},"obj":"Gene"},{"id":"1661","span":{"begin":91,"end":96},"obj":"Species"},{"id":"1662","span":{"begin":373,"end":377},"obj":"Species"},{"id":"1674","span":{"begin":199,"end":202},"obj":"Species"},{"id":"1676","span":{"begin":105,"end":121},"obj":"Disease"},{"id":"1717","span":{"begin":8,"end":12},"obj":"Gene"},{"id":"1722","span":{"begin":45,"end":49},"obj":"Gene"}],"attributes":[{"id":"A1627","pred":"tao:has_database_id","subj":"1627","obj":"Gene:6352"},{"id":"A1628","pred":"tao:has_database_id","subj":"1628","obj":"Gene:6347"},{"id":"A1629","pred":"tao:has_database_id","subj":"1629","obj":"Gene:14580"},{"id":"A1630","pred":"tao:has_database_id","subj":"1630","obj":"Gene:14580"},{"id":"A1631","pred":"tao:has_database_id","subj":"1631","obj":"Gene:12772"},{"id":"A1661","pred":"tao:has_database_id","subj":"1661","obj":"Tax:11676"},{"id":"A1662","pred":"tao:has_database_id","subj":"1662","obj":"Tax:10090"},{"id":"A1674","pred":"tao:has_database_id","subj":"1674","obj":"Tax:12721"},{"id":"A1676","pred":"tao:has_database_id","subj":"1676","obj":"MESH:D007249"},{"id":"A1717","pred":"tao:has_database_id","subj":"1717","obj":"Gene:3569"},{"id":"A1722","pred":"tao:has_database_id","subj":"1722","obj":"Gene:55510"},{"subj":"1627","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1628","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1629","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1630","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1631","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1661","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1662","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1674","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1676","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1717","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1722","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T74","span":{"begin":13,"end":26},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T75","span":{"begin":109,"end":121},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T76","span":{"begin":249,"end":267},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T77","span":{"begin":249,"end":258},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"attributes":[{"subj":"T74","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T685","span":{"begin":57,"end":64},"obj":"Sentence"},{"id":"T686","span":{"begin":65,"end":268},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T685","pred":"source","obj":"LitCovid-sentences"},{"subj":"T686","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d7ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#e793ec"},{"id":"LitCovid-PD-MONDO","color":"#93eccd"},{"id":"LitCovid-PD-CLO","color":"#ecb393"},{"id":"LitCovid-PD-CHEBI","color":"#9993ec"},{"id":"LitCovid-PubTator","color":"#a7ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93c1"},{"id":"LitCovid-sentences","color":"#93dbec"}]}]}}