PMC:7463108 / 41107-41959 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T408","span":{"begin":193,"end":196},"obj":"Body_part"},{"id":"T409","span":{"begin":324,"end":334},"obj":"Body_part"},{"id":"T410","span":{"begin":471,"end":474},"obj":"Body_part"},{"id":"T411","span":{"begin":509,"end":519},"obj":"Body_part"},{"id":"T412","span":{"begin":523,"end":526},"obj":"Body_part"},{"id":"T413","span":{"begin":536,"end":539},"obj":"Body_part"},{"id":"T414","span":{"begin":540,"end":546},"obj":"Body_part"},{"id":"T415","span":{"begin":721,"end":729},"obj":"Body_part"}],"attributes":[{"id":"A408","pred":"fma_id","subj":"T408","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A409","pred":"fma_id","subj":"T409","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A410","pred":"fma_id","subj":"T410","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A411","pred":"fma_id","subj":"T411","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A412","pred":"fma_id","subj":"T412","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A413","pred":"fma_id","subj":"T413","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A414","pred":"fma_id","subj":"T414","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A415","pred":"fma_id","subj":"T415","obj":"http://purl.org/sig/ont/fma/fma67408"}],"text":"Although the extent to which astroglia display productive infection is debated (Russell et al. 2017; Ko et al. 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al. 2003; Churchill et al. 2009), infectious animal models (Eugenin et al. 2011), and/or cultured human fetal astrocytes (Tornatore et al. 1994; Liu et al. 2004; Do et al. 2014; Narasipura et al. 2014; Li et al. 2015; Nath 2015; Li et al. 2020). Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al. 2006). Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al. 2004; Do et al. 2014; Li et al. 2015; Nath 2015; Al-Harthi et al. 2019; Li et al. 2020)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T92","span":{"begin":193,"end":196},"obj":"Body_part"},{"id":"T93","span":{"begin":536,"end":539},"obj":"Body_part"},{"id":"T94","span":{"begin":540,"end":546},"obj":"Body_part"}],"attributes":[{"id":"A92","pred":"uberon_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A93","pred":"uberon_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A94","pred":"uberon_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Although the extent to which astroglia display productive infection is debated (Russell et al. 2017; Ko et al. 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al. 2003; Churchill et al. 2009), infectious animal models (Eugenin et al. 2011), and/or cultured human fetal astrocytes (Tornatore et al. 1994; Liu et al. 2004; Do et al. 2014; Narasipura et al. 2014; Li et al. 2015; Nath 2015; Li et al. 2020). Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al. 2006). Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al. 2004; Do et al. 2014; Li et al. 2015; Nath 2015; Al-Harthi et al. 2019; Li et al. 2020)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T119","span":{"begin":58,"end":67},"obj":"Disease"},{"id":"T120","span":{"begin":248,"end":258},"obj":"Disease"}],"attributes":[{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Although the extent to which astroglia display productive infection is debated (Russell et al. 2017; Ko et al. 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al. 2003; Churchill et al. 2009), infectious animal models (Eugenin et al. 2011), and/or cultured human fetal astrocytes (Tornatore et al. 1994; Liu et al. 2004; Do et al. 2014; Narasipura et al. 2014; Li et al. 2015; Nath 2015; Li et al. 2020). Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al. 2006). Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al. 2004; Do et al. 2014; Li et al. 2015; Nath 2015; Al-Harthi et al. 2019; Li et al. 2020)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T510","span":{"begin":193,"end":196},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T511","span":{"begin":193,"end":196},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T512","span":{"begin":193,"end":196},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T513","span":{"begin":259,"end":265},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T514","span":{"begin":312,"end":317},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T515","span":{"begin":324,"end":334},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T516","span":{"begin":416,"end":418},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T517","span":{"begin":416,"end":418},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T518","span":{"begin":443,"end":445},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T519","span":{"begin":443,"end":445},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T520","span":{"begin":509,"end":519},"obj":"http://purl.obolibrary.org/obo/CL_0000127"},{"id":"T521","span":{"begin":536,"end":539},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T522","span":{"begin":536,"end":539},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T523","span":{"begin":536,"end":539},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T524","span":{"begin":651,"end":654},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T525","span":{"begin":786,"end":788},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T526","span":{"begin":786,"end":788},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T16796","span":{"begin":836,"end":838},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T528","span":{"begin":836,"end":838},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"}],"text":"Although the extent to which astroglia display productive infection is debated (Russell et al. 2017; Ko et al. 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al. 2003; Churchill et al. 2009), infectious animal models (Eugenin et al. 2011), and/or cultured human fetal astrocytes (Tornatore et al. 1994; Liu et al. 2004; Do et al. 2014; Narasipura et al. 2014; Li et al. 2015; Nath 2015; Li et al. 2020). Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al. 2006). Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al. 2004; Do et al. 2014; Li et al. 2015; Nath 2015; Al-Harthi et al. 2019; Li et al. 2020)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T435","span":{"begin":101,"end":103},"obj":"Chemical"},{"id":"T436","span":{"begin":416,"end":418},"obj":"Chemical"},{"id":"T437","span":{"begin":443,"end":445},"obj":"Chemical"},{"id":"T438","span":{"begin":786,"end":788},"obj":"Chemical"},{"id":"T439","span":{"begin":813,"end":815},"obj":"Chemical"},{"id":"T440","span":{"begin":836,"end":838},"obj":"Chemical"}],"attributes":[{"id":"A435","pred":"chebi_id","subj":"T435","obj":"http://purl.obolibrary.org/obo/CHEBI_59348"},{"id":"A436","pred":"chebi_id","subj":"T436","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A437","pred":"chebi_id","subj":"T437","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A438","pred":"chebi_id","subj":"T438","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A439","pred":"chebi_id","subj":"T439","obj":"http://purl.obolibrary.org/obo/CHEBI_28984"},{"id":"A440","pred":"chebi_id","subj":"T440","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"}],"text":"Although the extent to which astroglia display productive infection is debated (Russell et al. 2017; Ko et al. 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al. 2003; Churchill et al. 2009), infectious animal models (Eugenin et al. 2011), and/or cultured human fetal astrocytes (Tornatore et al. 1994; Liu et al. 2004; Do et al. 2014; Narasipura et al. 2014; Li et al. 2015; Nath 2015; Li et al. 2020). Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al. 2006). Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al. 2004; Do et al. 2014; Li et al. 2015; Nath 2015; Al-Harthi et al. 2019; Li et al. 2020)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1514","span":{"begin":651,"end":654},"obj":"Gene"},{"id":"1517","span":{"begin":224,"end":233},"obj":"Species"},{"id":"1518","span":{"begin":312,"end":317},"obj":"Species"},{"id":"1519","span":{"begin":581,"end":590},"obj":"Species"},{"id":"1520","span":{"begin":471,"end":474},"obj":"Species"},{"id":"1521","span":{"begin":58,"end":67},"obj":"Disease"},{"id":"1523","span":{"begin":523,"end":535},"obj":"Disease"}],"attributes":[{"id":"A1514","pred":"tao:has_database_id","subj":"1514","obj":"Gene:920"},{"id":"A1517","pred":"tao:has_database_id","subj":"1517","obj":"Tax:868862"},{"id":"A1518","pred":"tao:has_database_id","subj":"1518","obj":"Tax:9606"},{"id":"A1519","pred":"tao:has_database_id","subj":"1519","obj":"Tax:868862"},{"id":"A1520","pred":"tao:has_database_id","subj":"1520","obj":"Tax:12721"},{"id":"A1521","pred":"tao:has_database_id","subj":"1521","obj":"MESH:D007239"},{"id":"A1523","pred":"tao:has_database_id","subj":"1523","obj":"MESH:D015658"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Although the extent to which astroglia display productive infection is debated (Russell et al. 2017; Ko et al. 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al. 2003; Churchill et al. 2009), infectious animal models (Eugenin et al. 2011), and/or cultured human fetal astrocytes (Tornatore et al. 1994; Liu et al. 2004; Do et al. 2014; Narasipura et al. 2014; Li et al. 2015; Nath 2015; Li et al. 2020). Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al. 2006). Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al. 2004; Do et al. 2014; Li et al. 2015; Nath 2015; Al-Harthi et al. 2019; Li et al. 2020)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T619","span":{"begin":0,"end":94},"obj":"Sentence"},{"id":"T620","span":{"begin":95,"end":110},"obj":"Sentence"},{"id":"T621","span":{"begin":111,"end":217},"obj":"Sentence"},{"id":"T622","span":{"begin":218,"end":240},"obj":"Sentence"},{"id":"T623","span":{"begin":241,"end":288},"obj":"Sentence"},{"id":"T624","span":{"begin":289,"end":352},"obj":"Sentence"},{"id":"T625","span":{"begin":353,"end":369},"obj":"Sentence"},{"id":"T626","span":{"begin":370,"end":385},"obj":"Sentence"},{"id":"T627","span":{"begin":386,"end":409},"obj":"Sentence"},{"id":"T628","span":{"begin":410,"end":425},"obj":"Sentence"},{"id":"T629","span":{"begin":426,"end":452},"obj":"Sentence"},{"id":"T630","span":{"begin":453,"end":459},"obj":"Sentence"},{"id":"T631","span":{"begin":460,"end":597},"obj":"Sentence"},{"id":"T632","span":{"begin":598,"end":604},"obj":"Sentence"},{"id":"T633","span":{"begin":605,"end":763},"obj":"Sentence"},{"id":"T634","span":{"begin":764,"end":779},"obj":"Sentence"},{"id":"T635","span":{"begin":780,"end":795},"obj":"Sentence"},{"id":"T636","span":{"begin":796,"end":829},"obj":"Sentence"},{"id":"T637","span":{"begin":830,"end":845},"obj":"Sentence"},{"id":"T638","span":{"begin":846,"end":852},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Although the extent to which astroglia display productive infection is debated (Russell et al. 2017; Ko et al. 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al. 2003; Churchill et al. 2009), infectious animal models (Eugenin et al. 2011), and/or cultured human fetal astrocytes (Tornatore et al. 1994; Liu et al. 2004; Do et al. 2014; Narasipura et al. 2014; Li et al. 2015; Nath 2015; Li et al. 2020). Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al. 2006). Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al. 2004; Do et al. 2014; Li et al. 2015; Nath 2015; Al-Harthi et al. 2019; Li et al. 2020)."}

{"project":"2_test","denotations":[{"id":"32876803-28178524-62958062","span":{"begin":95,"end":99},"obj":"28178524"},{"id":"32876803-30194646-62958063","span":{"begin":111,"end":115},"obj":"30194646"},{"id":"32876803-15049431-62958064","span":{"begin":218,"end":222},"obj":"15049431"},{"id":"32876803-19743454-62958065","span":{"begin":241,"end":245},"obj":"19743454"},{"id":"32876803-21715610-62958066","span":{"begin":289,"end":293},"obj":"21715610"},{"id":"32876803-8254781-62958067","span":{"begin":353,"end":357},"obj":"8254781"},{"id":"32876803-15047828-62958068","span":{"begin":370,"end":374},"obj":"15047828"},{"id":"32876803-24965444-62958069","span":{"begin":386,"end":390},"obj":"24965444"},{"id":"32876803-24352441-62958070","span":{"begin":410,"end":414},"obj":"24352441"},{"id":"32876803-25985398-62958071","span":{"begin":426,"end":430},"obj":"25985398"},{"id":"32876803-15047828-62958072","span":{"begin":764,"end":768},"obj":"15047828"},{"id":"32876803-24965444-62958073","span":{"begin":780,"end":784},"obj":"24965444"},{"id":"32876803-25985398-62958074","span":{"begin":796,"end":800},"obj":"25985398"}],"text":"Although the extent to which astroglia display productive infection is debated (Russell et al. 2017; Ko et al. 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al. 2003; Churchill et al. 2009), infectious animal models (Eugenin et al. 2011), and/or cultured human fetal astrocytes (Tornatore et al. 1994; Liu et al. 2004; Do et al. 2014; Narasipura et al. 2014; Li et al. 2015; Nath 2015; Li et al. 2020). Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al. 2006). Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al. 2004; Do et al. 2014; Li et al. 2015; Nath 2015; Al-Harthi et al. 2019; Li et al. 2020)."}