PMC:7463108 / 39587-40497 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"ARV, antiretroviral(s); BMVEC, brain vascular endothelial cells; [Ca2+]i intracellular calcium concentration; 8-CAC, 8-carboxamidocyclazocine; DAMGO, D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DCF, dihydro-dichlorofluorescein; DOR, δ-opioid receptor; DHE, dihydroethidium; DTG, dolutegravir; DPDPE, [D-Pen2,D-Pen5]enkephalin; FTC, emtricitabine; GABA, γ-aminobutyric acid; Iba1, ionized calcium-binding adapter molecule 1; JAM-1, junctional adhesion molecule-1; KCC2, K+-Cl− cotransporter 2; KOR, κ-opioid receptor; LTR, long terminal repeat; ΔΨm, mitochondrial inner membrane potential; MOR, μ-opioid receptor; [Na+]i, intracellular sodium concentration; nor-BNI, nor-binaltorphimine; NPCs, neural progenitor cells; OLs, oligodendroglia; ROS, reactive oxygen species; TEER, transendothelial electrical resistance; TFV, tenofovir; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; ZDV, zidovudine","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T392","span":{"begin":31,"end":36},"obj":"Body_part"},{"id":"T393","span":{"begin":46,"end":63},"obj":"Body_part"},{"id":"T394","span":{"begin":58,"end":63},"obj":"Body_part"},{"id":"T395","span":{"begin":176,"end":186},"obj":"Body_part"},{"id":"T396","span":{"begin":309,"end":319},"obj":"Body_part"},{"id":"T397","span":{"begin":705,"end":710},"obj":"Body_part"},{"id":"T398","span":{"begin":717,"end":732},"obj":"Body_part"}],"attributes":[{"id":"A392","pred":"fma_id","subj":"T392","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A393","pred":"fma_id","subj":"T393","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A394","pred":"fma_id","subj":"T394","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A395","pred":"fma_id","subj":"T395","obj":"http://purl.org/sig/ont/fma/fma83367"},{"id":"A396","pred":"fma_id","subj":"T396","obj":"http://purl.org/sig/ont/fma/fma83367"},{"id":"A397","pred":"fma_id","subj":"T397","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A398","pred":"fma_id","subj":"T398","obj":"http://purl.org/sig/ont/fma/fma83665"},{"subj":"T392","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T393","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T394","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T395","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T396","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T397","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T398","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T86","span":{"begin":31,"end":36},"obj":"Body_part"}],"attributes":[{"id":"A86","pred":"uberon_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T118","span":{"begin":321,"end":324},"obj":"Disease"}],"attributes":[{"id":"A118","pred":"mondo_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/MONDO_0008566"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T491","span":{"begin":31,"end":36},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T492","span":{"begin":31,"end":36},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T493","span":{"begin":46,"end":63},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T494","span":{"begin":425,"end":435},"obj":"http://purl.obolibrary.org/obo/UBERON_0007651"},{"id":"T495","span":{"begin":466,"end":468},"obj":"http://purl.obolibrary.org/obo/CLO_0052906"},{"id":"T496","span":{"begin":563,"end":571},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T497","span":{"begin":705,"end":710},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T498","span":{"begin":833,"end":870},"obj":"http://purl.obolibrary.org/obo/PR_000006611"},{"id":"T499","span":{"begin":885,"end":893},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"}],"attributes":[{"subj":"T491","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T492","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T493","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T494","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T495","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T496","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T497","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T498","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T499","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T410","span":{"begin":87,"end":94},"obj":"Chemical"},{"id":"T412","span":{"begin":143,"end":148},"obj":"Chemical"},{"id":"T413","span":{"begin":168,"end":171},"obj":"Chemical"},{"id":"T414","span":{"begin":273,"end":285},"obj":"Chemical"},{"id":"T415","span":{"begin":287,"end":292},"obj":"Chemical"},{"id":"T416","span":{"begin":326,"end":339},"obj":"Chemical"},{"id":"T417","span":{"begin":341,"end":345},"obj":"Chemical"},{"id":"T418","span":{"begin":362,"end":366},"obj":"Chemical"},{"id":"T419","span":{"begin":382,"end":389},"obj":"Chemical"},{"id":"T421","span":{"begin":406,"end":414},"obj":"Chemical"},{"id":"T422","span":{"begin":445,"end":453},"obj":"Chemical"},{"id":"T423","span":{"begin":466,"end":468},"obj":"Chemical"},{"id":"T424","span":{"begin":608,"end":610},"obj":"Chemical"},{"id":"T425","span":{"begin":629,"end":635},"obj":"Chemical"},{"id":"T426","span":{"begin":734,"end":737},"obj":"Chemical"},{"id":"T427","span":{"begin":739,"end":762},"obj":"Chemical"},{"id":"T428","span":{"begin":748,"end":754},"obj":"Chemical"},{"id":"T429","span":{"begin":815,"end":824},"obj":"Chemical"},{"id":"T432","span":{"begin":871,"end":875},"obj":"Chemical"},{"id":"T434","span":{"begin":900,"end":910},"obj":"Chemical"}],"attributes":[{"id":"A410","pred":"chebi_id","subj":"T410","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A411","pred":"chebi_id","subj":"T410","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A412","pred":"chebi_id","subj":"T412","obj":"http://purl.obolibrary.org/obo/CHEBI_272"},{"id":"A413","pred":"chebi_id","subj":"T413","obj":"http://purl.obolibrary.org/obo/CHEBI_15428"},{"id":"A414","pred":"chebi_id","subj":"T414","obj":"http://purl.obolibrary.org/obo/CHEBI_76010"},{"id":"A415","pred":"chebi_id","subj":"T415","obj":"http://purl.obolibrary.org/obo/CHEBI_73356"},{"id":"A416","pred":"chebi_id","subj":"T416","obj":"http://purl.obolibrary.org/obo/CHEBI_31536"},{"id":"A417","pred":"chebi_id","subj":"T417","obj":"http://purl.obolibrary.org/obo/CHEBI_16865"},{"id":"A418","pred":"chebi_id","subj":"T418","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A419","pred":"chebi_id","subj":"T419","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A420","pred":"chebi_id","subj":"T419","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A421","pred":"chebi_id","subj":"T421","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A422","pred":"chebi_id","subj":"T422","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A423","pred":"chebi_id","subj":"T423","obj":"http://purl.obolibrary.org/obo/CHEBI_23116"},{"id":"A424","pred":"chebi_id","subj":"T424","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A425","pred":"chebi_id","subj":"T425","obj":"http://purl.obolibrary.org/obo/CHEBI_26708"},{"id":"A426","pred":"chebi_id","subj":"T426","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A427","pred":"chebi_id","subj":"T427","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A428","pred":"chebi_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A429","pred":"chebi_id","subj":"T429","obj":"http://purl.obolibrary.org/obo/CHEBI_134504"},{"id":"A430","pred":"chebi_id","subj":"T429","obj":"http://purl.obolibrary.org/obo/CHEBI_63625"},{"id":"A431","pred":"chebi_id","subj":"T429","obj":"http://purl.obolibrary.org/obo/CHEBI_63716"},{"id":"A432","pred":"chebi_id","subj":"T432","obj":"http://purl.obolibrary.org/obo/CHEBI_17625"},{"id":"A433","pred":"chebi_id","subj":"T432","obj":"http://purl.obolibrary.org/obo/CHEBI_61555"},{"id":"A434","pred":"chebi_id","subj":"T434","obj":"http://purl.obolibrary.org/obo/CHEBI_10110"},{"subj":"T410","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T412","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T413","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T414","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T415","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T416","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T417","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T418","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T419","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T421","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T422","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T423","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T424","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T425","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T426","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T427","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T428","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T429","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T432","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T434","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1482","span":{"begin":222,"end":225},"obj":"Gene"},{"id":"1483","span":{"begin":368,"end":372},"obj":"Gene"},{"id":"1484","span":{"begin":374,"end":416},"obj":"Gene"},{"id":"1485","span":{"begin":418,"end":423},"obj":"Gene"},{"id":"1486","span":{"begin":425,"end":455},"obj":"Gene"},{"id":"1487","span":{"begin":457,"end":461},"obj":"Gene"},{"id":"1488","span":{"begin":463,"end":485},"obj":"Gene"},{"id":"1489","span":{"begin":487,"end":490},"obj":"Gene"},{"id":"1490","span":{"begin":492,"end":509},"obj":"Gene"},{"id":"1491","span":{"begin":583,"end":586},"obj":"Gene"},{"id":"1492","span":{"begin":588,"end":605},"obj":"Gene"},{"id":"1493","span":{"begin":538,"end":541},"obj":"Disease"}],"attributes":[{"id":"A1482","pred":"tao:has_database_id","subj":"1482","obj":"Gene:58476"},{"id":"A1483","pred":"tao:has_database_id","subj":"1483","obj":"Gene:199"},{"id":"A1484","pred":"tao:has_database_id","subj":"1484","obj":"Gene:199"},{"id":"A1485","pred":"tao:has_database_id","subj":"1485","obj":"Gene:50848"},{"id":"A1486","pred":"tao:has_database_id","subj":"1486","obj":"Gene:50848"},{"id":"A1487","pred":"tao:has_database_id","subj":"1487","obj":"Gene:57468"},{"id":"A1488","pred":"tao:has_database_id","subj":"1488","obj":"Gene:57468"},{"id":"A1489","pred":"tao:has_database_id","subj":"1489","obj":"Gene:4986"},{"id":"A1490","pred":"tao:has_database_id","subj":"1490","obj":"Gene:4986"},{"id":"A1491","pred":"tao:has_database_id","subj":"1491","obj":"Gene:4988"},{"id":"A1492","pred":"tao:has_database_id","subj":"1492","obj":"Gene:4988"},{"subj":"1482","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1483","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1484","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1485","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1486","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1487","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1488","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1489","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1490","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1491","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1492","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1493","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T615","span":{"begin":0,"end":910},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T615","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecea","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecd093"},{"id":"LitCovid-PD-MONDO","color":"#b693ec"},{"id":"LitCovid-PD-CLO","color":"#93ec9c"},{"id":"LitCovid-PD-CHEBI","color":"#ec93a3"},{"id":"LitCovid-PubTator","color":"#93bdec"},{"id":"LitCovid-sentences","color":"#d7ec93"}]}]}}