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PMC:7463108 / 29794-41055 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T246 85-92 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T247 97-101 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T248 260-282 Body_part denotes enteric nervous system http://purl.org/sig/ont/fma/fma66070
T249 325-328 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T250 487-491 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T251 502-507 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T252 672-675 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T253 676-680 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T254 795-798 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T255 871-875 Body_part denotes Glia http://purl.org/sig/ont/fma/fma54541
T256 876-879 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T257 891-894 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T258 939-942 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T259 997-1001 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T260 1006-1013 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T261 1026-1038 Body_part denotes neural cells http://purl.org/sig/ont/fma/fma70333
T262 1033-1038 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T263 1040-1043 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T264 1053-1064 Body_part denotes promonocyte http://purl.org/sig/ont/fma/fma83551
T265 1209-1212 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T266 1238-1245 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T267 1250-1254 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T268 1275-1285 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T269 1388-1392 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T270 1446-1449 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T271 1532-1542 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T272 1583-1587 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T273 1752-1756 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T274 1994-2003 Body_part denotes Astrocyte http://purl.org/sig/ont/fma/fma54537
T275 2050-2054 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T276 2144-2152 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T277 2185-2189 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T278 2233-2240 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T279 2245-2249 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T280 2268-2271 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T281 2394-2397 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T282 2430-2439 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T283 2503-2506 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T284 2541-2546 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T285 2562-2572 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T286 2577-2586 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T287 2597-2602 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T288 2642-2645 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T289 2682-2689 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T290 2732-2735 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T291 2750-2754 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T292 2924-2934 Body_part denotes Astrocytes http://purl.org/sig/ont/fma/fma54537
T293 2935-2938 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T294 2980-2983 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T295 3012-3022 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T296 3213-3223 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T297 3247-3257 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T298 3329-3339 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T299 3440-3450 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T300 3633-3643 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T301 3775-3785 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T302 3882-3886 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T303 3901-3911 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T304 3992-4000 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T305 4061-4071 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T306 4222-4227 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T307 4228-4232 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T308 4403-4407 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T309 4417-4427 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T310 4453-4463 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T311 4483-4492 Body_part denotes Microglia http://purl.org/sig/ont/fma/fma68923
T312 4493-4496 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T313 4577-4580 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T314 4690-4699 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T315 4751-4754 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T316 4774-4783 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T317 4877-4880 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T318 4900-4909 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T319 4973-4976 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T320 4992-4995 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T321 5034-5038 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T322 5063-5072 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T323 5236-5239 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T324 5247-5258 Body_part denotes fetal brain http://purl.org/sig/ont/fma/fma312981
T325 5259-5268 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T326 5433-5444 Body_part denotes fetal brain http://purl.org/sig/ont/fma/fma312981
T327 5445-5454 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T328 5465-5472 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T329 5473-5477 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T330 5498-5501 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T331 5634-5643 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T332 5657-5666 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T333 5671-5683 Body_part denotes neural cells http://purl.org/sig/ont/fma/fma70333
T334 5678-5683 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T335 5703-5713 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T336 5718-5727 Body_part denotes Cytokines http://purl.org/sig/ont/fma/fma84050
T337 5835-5844 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T338 5933-5937 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T339 5960-5969 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T340 6081-6088 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T341 6121-6130 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T342 6293-6302 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T343 6323-6330 Body_part denotes Neurons http://purl.org/sig/ont/fma/fma54527
T344 6331-6334 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T345 6346-6349 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T346 6364-6367 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T347 6416-6421 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T348 6551-6560 Body_part denotes Dendritic http://purl.org/sig/ont/fma/fma67314
T349 6589-6596 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T350 6823-6830 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T351 6862-6869 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T352 6900-6907 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T353 6931-6936 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T354 6986-6994 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T355 7028-7036 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T356 7170-7177 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T357 7188-7192 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T358 7399-7407 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T359 7421-7429 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T360 7538-7545 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T361 7556-7560 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T362 7604-7616 Body_part denotes White matter http://purl.org/sig/ont/fma/fma83929
T363 7864-7869 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T364 7870-7875 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T365 8016-8024 Body_part denotes Monocyte http://purl.org/sig/ont/fma/fma62864
T366 8089-8099 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T367 8220-8230 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T368 8251-8254 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T369 8276-8284 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T370 8333-8341 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T371 8368-8372 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T372 8384-8394 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T373 8413-8422 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T374 8452-8459 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T375 8470-8474 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T376 8550-8558 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T377 8583-8587 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T378 8703-8710 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T379 8721-8725 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T380 8812-8827 Body_part denotes oligodendroglia http://purl.org/sig/ont/fma/fma83665
T381 8955-8958 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T382 8984-8987 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T383 9007-9010 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T384 9036-9039 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T385 9274-9277 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T386 9344-9351 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T387 9614-9621 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T388 9626-9630 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T389 9641-9648 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T390 9650-9660 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T391 9665-9674 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T392 9824-9829 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T393 9839-9856 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T394 9851-9856 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T395 9969-9979 Body_part denotes enkephalin http://purl.org/sig/ont/fma/fma83367
T396 10102-10112 Body_part denotes enkephalin http://purl.org/sig/ont/fma/fma83367
T397 10498-10503 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T398 10510-10525 Body_part denotes oligodendroglia http://purl.org/sig/ont/fma/fma83665
T399 10765-10768 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T400 10929-10932 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T401 10966-10977 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T402 10982-10991 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T403 11021-11043 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T404 11059-11062 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T405 11101-11126 Body_part denotes peripheral nervous system http://purl.org/sig/ont/fma/fma9903
T406 11174-11177 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T76 260-282 Body_part denotes enteric nervous system http://purl.obolibrary.org/obo/UBERON_0002005
T77 268-282 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T78 502-507 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T79 672-675 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T80 4222-4227 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T81 5253-5258 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T82 5439-5444 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T83 7604-7616 Body_part denotes White matter http://purl.obolibrary.org/obo/UBERON_0002316
T84 7864-7883 Body_part denotes Blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T85 7870-7875 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T86 9824-9829 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T87 10765-10768 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T88 11021-11043 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T89 11029-11043 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T90 11101-11126 Body_part denotes peripheral nervous system http://purl.obolibrary.org/obo/UBERON_0000010
T91 11112-11126 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T77 1426-1428 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T78 1899-1902 Disease denotes NPC http://purl.obolibrary.org/obo/MONDO_0011775|http://purl.obolibrary.org/obo/MONDO_0015459|http://purl.obolibrary.org/obo/MONDO_0018982
T81 2316-2318 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T82 2394-2407 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T83 2398-2407 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 2712-2714 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T85 2960-2962 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T86 3866-3877 Disease denotes astrocytoma http://purl.obolibrary.org/obo/MONDO_0019781|http://purl.obolibrary.org/obo/MONDO_0021636
T88 4270-4282 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T89 4519-4521 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T90 4733-4735 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T91 4816-4818 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T92 4942-4944 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T93 5013-5022 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T94 5591-5604 Disease denotes Neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T95 5818-5820 Disease denotes BV http://purl.obolibrary.org/obo/MONDO_0005316
T96 6402-6415 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T97 6460-6466 Disease denotes Injury http://purl.obolibrary.org/obo/MONDO_0021178
T98 6917-6930 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T99 7508-7521 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T100 8151-8154 Disease denotes FTC http://purl.obolibrary.org/obo/MONDO_0008566
T101 8532-8534 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T102 8642-8644 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T103 8840-8842 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T104 8951-8954 Disease denotes NPC http://purl.obolibrary.org/obo/MONDO_0011775|http://purl.obolibrary.org/obo/MONDO_0015459|http://purl.obolibrary.org/obo/MONDO_0018982
T107 8974-8976 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T108 9003-9006 Disease denotes NPC http://purl.obolibrary.org/obo/MONDO_0011775|http://purl.obolibrary.org/obo/MONDO_0015459|http://purl.obolibrary.org/obo/MONDO_0018982
T111 9150-9152 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T112 9163-9166 Disease denotes ADA http://purl.obolibrary.org/obo/MONDO_0007064
T113 9271-9273 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T114 9304-9317 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T115 9446-9448 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T116 9527-9540 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T117 9589-9602 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T118 10114-10117 Disease denotes FTC http://purl.obolibrary.org/obo/MONDO_0008566

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T335 223-229 http://purl.obolibrary.org/obo/CLO_0007900 denotes Murphy
T336 487-497 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T337 502-507 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T338 502-507 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T339 601-605 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T340 608-609 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T78283 672-675 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T342 672-675 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T343 672-675 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T344 676-686 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T345 1014-1019 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T346 1033-1038 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T347 1053-1064 http://purl.obolibrary.org/obo/CL_0000559 denotes promonocyte
T348 1217-1222 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T349 1367-1372 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T350 1410-1414 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T351 1532-1542 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T352 1562-1567 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T353 1737-1756 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation & ↑ cell
T354 1824-1829 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T355 1994-2003 http://purl.obolibrary.org/obo/CL_0000127 denotes Astrocyte
T356 2029-2034 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T357 2171-2181 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T358 2218-2223 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T359 2262-2266 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T360 2430-2439 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T361 2522-2525 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T362 2541-2546 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T363 2547-2552 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T364 2562-2572 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T365 2577-2586 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T366 2592-2596 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T367 2592-2596 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T368 2592-2596 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T369 2597-2602 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T370 2875-2880 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T371 2924-2934 http://purl.obolibrary.org/obo/CL_0000127 denotes Astrocytes
T372 2997-3002 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T373 3012-3022 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T374 3126-3130 http://purl.obolibrary.org/obo/CLO_0050768 denotes TLR2
T375 3198-3203 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T376 3213-3223 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T377 3314-3319 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T378 3329-3339 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T379 3425-3430 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T380 3440-3450 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T381 3540-3541 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T382 3618-3623 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T383 3633-3643 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T384 3758-3759 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T385 3760-3765 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T386 3775-3785 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T387 3808-3809 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T388 3848-3852 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T389 3859-3864 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T390 3882-3891 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T391 3901-3911 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T392 4046-4051 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T393 4061-4071 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T394 4208-4213 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T395 4222-4227 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T396 4222-4227 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T397 4228-4237 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T398 4239-4246 http://purl.obolibrary.org/obo/CLO_0009059 denotes SK-N-SH
T399 4239-4246 http://purl.obolibrary.org/obo/CLO_0050268 denotes SK-N-SH
T400 4239-4246 http://purl.obolibrary.org/obo/CLO_0052143 denotes SK-N-SH
T401 4239-4246 http://purl.obolibrary.org/obo/CLO_0052144 denotes SK-N-SH
T402 4239-4246 http://purl.obolibrary.org/obo/CLO_0052145 denotes SK-N-SH
T403 4348-4357 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T404 4417-4427 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T405 4428-4429 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T406 4430-4435 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T407 4437-4442 http://purl.obolibrary.org/obo/CLO_0009464 denotes U87MG
T408 4453-4463 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T409 4483-4492 http://purl.obolibrary.org/obo/CL_0000129 denotes Microglia
T410 4675-4680 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T411 4690-4699 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T412 4759-4764 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T413 4774-4783 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T414 4885-4890 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T415 4900-4909 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T416 4938-4940 http://purl.obolibrary.org/obo/CLO_0003358 denotes FL
T417 5050-5055 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T418 5063-5072 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T419 5240-5245 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T420 5253-5258 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T421 5253-5258 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T422 5259-5268 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T423 5426-5431 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T424 5439-5444 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T425 5439-5444 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T426 5445-5454 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T427 5634-5643 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T428 5644-5649 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T429 5657-5666 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T430 5678-5683 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T431 5811-5816 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T432 5818-5822 http://purl.obolibrary.org/obo/CLO_0052671 denotes BV-2
T433 5835-5844 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T434 5871-5880 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T435 5938-5943 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T436 5960-5969 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T437 6099-6104 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T438 6121-6130 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T439 6225-6227 http://purl.obolibrary.org/obo/CLO_0009645 denotes xc
T440 6225-6227 http://purl.obolibrary.org/obo/CLO_0050824 denotes xc
T441 6278-6283 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T442 6293-6302 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T443 6379-6384 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T444 6394-6401 http://purl.obolibrary.org/obo/CLO_0009015 denotes SH-SY5Y
T445 6394-6401 http://purl.obolibrary.org/obo/CLO_0051795 denotes SH-SY5Y
T446 6394-6401 http://purl.obolibrary.org/obo/CLO_0052135 denotes SH-SY5Y
T447 6394-6401 http://purl.obolibrary.org/obo/CLO_0052139 denotes SH-SY5Y
T448 6394-6401 http://purl.obolibrary.org/obo/CLO_0052141 denotes SH-SY5Y
T449 6416-6421 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T450 6574-6579 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T451 6640-6648 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T452 6808-6813 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T453 6833-6838 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T454 6871-6876 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T455 6909-6916 http://purl.obolibrary.org/obo/CLO_0009015 denotes SH-SY5Y
T456 6909-6916 http://purl.obolibrary.org/obo/CLO_0051795 denotes SH-SY5Y
T457 6909-6916 http://purl.obolibrary.org/obo/CLO_0052135 denotes SH-SY5Y
T458 6909-6916 http://purl.obolibrary.org/obo/CLO_0052139 denotes SH-SY5Y
T459 6909-6916 http://purl.obolibrary.org/obo/CLO_0052141 denotes SH-SY5Y
T460 6931-6936 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T461 7155-7160 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T462 7263-7273 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T463 7319-7324 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T464 7484-7485 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T465 7523-7528 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T466 7805-7815 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T467 7816-7821 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T468 7864-7869 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T469 7864-7869 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T470 7870-7875 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T471 7870-7875 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T472 7978-7982 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T473 8016-8024 http://purl.obolibrary.org/obo/CL_0000576 denotes Monocyte
T474 8050-8055 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T475 8089-8099 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T476 8205-8210 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T477 8220-8230 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T478 8310-8311 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T479 8384-8394 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T480 8413-8422 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T481 8437-8442 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T482 8688-8693 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T483 9051-9056 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T484 9066-9071 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T485 9073-9078 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T486 9329-9334 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T487 9650-9660 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T488 9665-9674 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T489 9714-9715 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T490 9741-9742 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T491 9824-9829 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T492 9824-9829 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T493 9839-9856 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T494 10218-10228 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctional
T495 10259-10261 http://purl.obolibrary.org/obo/CLO_0052906 denotes Cl
T496 10356-10364 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T497 10498-10503 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T498 10626-10663 http://purl.obolibrary.org/obo/PR_000006611 denotes terminal deoxynucleotidyl transferase
T499 10678-10686 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeling
T500 10765-10768 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T501 10765-10768 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T502 10765-10768 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T503 10982-10991 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T504 11021-11043 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T505 11021-11043 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T506 11021-11043 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T507 11101-11126 http://purl.obolibrary.org/obo/UBERON_0000010 denotes peripheral nervous system
T508 11101-11126 http://www.ebi.ac.uk/efo/EFO_0000891 denotes peripheral nervous system
T509 11216-11217 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T233 39-44 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T234 468-472 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T235 900-909 Chemical denotes Dynorphin http://purl.obolibrary.org/obo/CHEBI_4727
T236 912-919 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T237 925-933 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T238 959-968 Chemical denotes Dynorphin http://purl.obolibrary.org/obo/CHEBI_4727
T239 974-981 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T240 992-994 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T242 1006-1013 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T243 1108-1115 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T244 1148-1156 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T245 1160-1168 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T246 1175-1183 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T247 1297-1305 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T248 1433-1441 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T249 1522-1528 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T250 1548-1550 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T252 1686-1694 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T253 1773-1781 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T255 1899-1902 Chemical denotes NPC http://purl.obolibrary.org/obo/CHEBI_80552
T256 1946-1954 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T257 2131-2139 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T258 2323-2331 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T259 2350-2356 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T260 2380-2386 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T261 2446-2454 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T263 2475-2481 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T264 2719-2727 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T265 2767-2775 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T267 2967-2975 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T268 3113-3121 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T269 3147-3155 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T271 3182-3190 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T273 3269-3277 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T274 3297-3299 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T276 3373-3381 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T277 3485-3493 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T278 3506-3508 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T280 3536-3538 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T283 3609-3617 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T285 3676-3683 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T286 3689-3696 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T287 3713-3723 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T288 3727-3734 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T289 3744-3751 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T290 3754-3756 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T293 3813-3821 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T294 3848-3850 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T296 3959-3967 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T297 4005-4008 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T298 4134-4139 Chemical denotes DPDPE http://purl.obolibrary.org/obo/CHEBI_73356
T299 4154-4162 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T300 4168-4176 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T301 4239-4241 Chemical denotes SK http://purl.obolibrary.org/obo/CHEBI_144702
T302 4244-4246 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T304 4327-4335 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T305 4528-4541 Chemical denotes Endomorphin-1 http://purl.obolibrary.org/obo/CHEBI_80156
T306 4544-4557 Chemical denotes Endomorphin-2 http://purl.obolibrary.org/obo/CHEBI_80157
T307 4563-4571 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T308 4629-4642 Chemical denotes Endomorphin-1 http://purl.obolibrary.org/obo/CHEBI_80156
T309 4740-4748 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T310 4825-4832 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T311 4847-4855 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T312 4859-4868 Chemical denotes Dynorphin http://purl.obolibrary.org/obo/CHEBI_4727
T313 4869-4871 Chemical denotes Al http://purl.obolibrary.org/obo/CHEBI_28984
T314 4938-4940 Chemical denotes FL http://purl.obolibrary.org/obo/CHEBI_91150
T315 5034-5036 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T317 5045-5047 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T319 5115-5122 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T320 5128-5136 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T321 5140-5147 Chemical denotes Cocaine http://purl.obolibrary.org/obo/CHEBI_27958
T322 5154-5161 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T323 5184-5195 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T324 5202-5209 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T325 5218-5225 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T327 5350-5357 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T328 5534-5541 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T329 5547-5554 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T330 5579-5586 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T331 5606-5613 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T332 5739-5747 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T333 5788-5790 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T335 5796-5801 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T336 5796-5798 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T337 5892-5900 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T338 6028-6036 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T339 6041-6044 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T340 6046-6048 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T341 6065-6069 Chemical denotes H2O2 http://purl.obolibrary.org/obo/CHEBI_16240
T342 6081-6088 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T343 6161-6170 Chemical denotes Glutamate http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237
T345 6190-6198 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T346 6201-6210 Chemical denotes Glutamate http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237
T348 6229-6236 Chemical denotes cystine http://purl.obolibrary.org/obo/CHEBI_17376
T349 6237-6246 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T351 6353-6361 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T352 6394-6396 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T354 6478-6486 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T355 6505-6507 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T356 6663-6666 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T357 6697-6705 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T358 6758-6766 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T360 6791-6807 Chemical denotes allopregnanolone http://purl.obolibrary.org/obo/CHEBI_50169
T361 6909-6911 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T363 7015-7023 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T364 7057-7065 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T366 7225-7233 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T367 7386-7394 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T368 7480-7482 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T371 7499-7507 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T373 7693-7701 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T374 7726-7734 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T376 7955-7963 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T377 7978-7980 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T379 8159-8167 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T380 8320-8328 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T381 8377-8380 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T382 8428-8436 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T384 8539-8547 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T385 8679-8687 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T387 8862-8870 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T388 8938-8946 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T390 8951-8954 Chemical denotes NPC http://purl.obolibrary.org/obo/CHEBI_80552
T391 8955-8958 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T392 8990-8998 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T394 9003-9006 Chemical denotes NPC http://purl.obolibrary.org/obo/CHEBI_80552
T395 9007-9010 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T396 9042-9050 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T398 9126-9130 Chemical denotes GABA http://purl.obolibrary.org/obo/CHEBI_16865
T399 9163-9166 Chemical denotes ADA http://purl.obolibrary.org/obo/CHEBI_39048
T400 9168-9170 Chemical denotes MN http://purl.obolibrary.org/obo/CHEBI_141442
T401 9195-9203 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T402 9213-9221 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T404 9320-9328 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T406 9455-9463 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T407 9474-9479 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T408 9482-9490 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T409 9543-9551 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T410 9880-9887 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T412 9936-9941 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T413 9961-9964 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T414 10066-10078 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T415 10080-10085 Chemical denotes DPDPE http://purl.obolibrary.org/obo/CHEBI_73356
T416 10119-10132 Chemical denotes emtricitabine http://purl.obolibrary.org/obo/CHEBI_31536
T417 10134-10138 Chemical denotes GABA http://purl.obolibrary.org/obo/CHEBI_16865
T418 10155-10159 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T419 10175-10182 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T421 10199-10207 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T422 10238-10246 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T423 10259-10261 Chemical denotes Cl http://purl.obolibrary.org/obo/CHEBI_23116
T424 10401-10403 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T425 10422-10428 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T426 10527-10530 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T427 10532-10555 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T428 10541-10547 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T429 10608-10617 Chemical denotes tenofovir http://purl.obolibrary.org/obo/CHEBI_134504|http://purl.obolibrary.org/obo/CHEBI_63625|http://purl.obolibrary.org/obo/CHEBI_63716
T432 10664-10668 Chemical denotes dUTP http://purl.obolibrary.org/obo/CHEBI_17625|http://purl.obolibrary.org/obo/CHEBI_61555
T434 10693-10703 Chemical denotes zidovudine http://purl.obolibrary.org/obo/CHEBI_10110

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1170 921-924 Gene denotes KOR Gene:4986
1171 970-973 Gene denotes KOR Gene:4986
1172 985-990 Gene denotes TNF-α Gene:7124
1173 992-996 Gene denotes IL-6 Gene:3569
1174 1144-1147 Gene denotes KOR Gene:4986
1175 1171-1174 Gene denotes KOR Gene:4986
1176 1186-1191 Gene denotes TNF-α Gene:7124
1177 1213-1216 Gene denotes p24 Gene:140767
1178 1286-1290 Gene denotes Tat1 Gene:72472
1179 1310-1314 Gene denotes CCL5 Gene:20304
1180 1316-1320 Gene denotes CCL2 Gene:20296
1181 1334-1341 Gene denotes Beclin1 Gene:56208
1182 1452-1455 Gene denotes Tat Gene:6898
1183 1483-1487 Gene denotes CCR5 Gene:1234
1184 1548-1552 Gene denotes IL-6 Gene:3569
1185 1557-1561 Gene denotes CCL5 Gene:6352
1186 1650-1653 Gene denotes MOR Gene:18390
1187 1655-1658 Gene denotes DOR Gene:18386
1188 1660-1663 Gene denotes KOR Gene:18387
1189 1675-1679 Gene denotes Tat1 Gene:72472
1190 1707-1710 Gene denotes DOR Gene:18386
1191 1718-1721 Gene denotes KOR Gene:18387
1192 1727-1736 Gene denotes Caspase-3 Gene:12367
1193 1766-1769 Gene denotes Tat Gene:234724
1194 1786-1789 Gene denotes DOR Gene:18386
1195 1791-1794 Gene denotes KOR Gene:18387
1196 1807-1810 Gene denotes Tat Gene:234724
1197 1875-1878 Gene denotes MOR Gene:18390
1198 1935-1939 Gene denotes Tat1 Gene:72472
1199 1957-1960 Gene denotes MOR Gene:18390
1200 2079-2082 Gene denotes MOR Gene:18390
1201 2087-2091 Gene denotes CCR5 Gene:12774
1202 2166-2170 Gene denotes CCR5 Gene:12774
1203 2202-2206 Gene denotes BDNF Gene:12064
1204 2284-2287 Gene denotes MOR Gene:4988
1205 2288-2292 Gene denotes CCR5 Gene:1234
1206 2362-2365 Gene denotes MOR Gene:4988
1207 2366-2370 Gene denotes CCR5 Gene:1234
1208 2457-2460 Gene denotes MOR Gene:4988
1209 2461-2465 Gene denotes CCR5 Gene:1234
1210 2507-2512 Gene denotes gp160 Gene:2028
1211 2517-2521 Gene denotes CCR5 Gene:1234
1212 2522-2525 Gene denotes CD4 Gene:920
1213 2736-2739 Gene denotes p24 Gene:140767
1214 2746-2749 Gene denotes Tat Gene:6898
1215 8180-8204 Gene denotes lular ARV concentrations Gene:6347
1342 1118-1121 Gene denotes U69 Gene:26779
1343 1108-1111 Gene denotes U50 Gene:692088
1344 912-915 Gene denotes U50 Gene:692088
1346 4755-4758 Gene denotes p24 Gene:140767
1347 2337-2340 Gene denotes MOR Gene:4988
1354 1592-1596 Gene denotes Hage Gene:55510
1355 939-944 Species denotes HIV-1 Tax:11676
1356 1014-1019 Species denotes Human Tax:9606
1357 1217-1222 Species denotes Human Tax:9606
1358 1367-1372 Species denotes Mouse Tax:10090
1359 1446-1451 Species denotes HIV-1 Tax:11676
1360 1562-1567 Species denotes Human Tax:9606
1361 1824-1829 Species denotes Mouse Tax:10090
1362 2029-2034 Species denotes Mouse Tax:10090
1363 2218-2223 Species denotes Mouse Tax:10090
1364 2547-2552 Species denotes Human Tax:9606
1365 2875-2880 Species denotes Human Tax:9606
1366 8205-8210 Species denotes Human Tax:9606
1370 8688-8693 Species denotes Mouse Tax:10090
1405 795-798 Species denotes HIV Tax:12721
1406 876-879 Species denotes HIV Tax:12721
1407 891-894 Species denotes HIV Tax:12721
1408 1209-1212 Species denotes HIV Tax:12721
1409 2268-2271 Species denotes HIV Tax:12721
1410 2503-2506 Species denotes HIV Tax:12721
1411 2642-2645 Species denotes HIV Tax:12721
1412 2732-2735 Species denotes HIV Tax:12721
1413 2935-2938 Species denotes HIV Tax:12721
1414 4751-4754 Species denotes HIV Tax:12721
1437 1040-1052 Disease denotes HIV-infected MESH:D015658
1438 1757-1762 Disease denotes death MESH:D003643
1439 2008-2028 Disease denotes immature glial death MESH:D003643
1440 2387-2407 Disease denotes blocks HIV infection MESH:D015658
1441 2694-2710 Disease denotes astroglia HIVBaL
1458 2537-2540 CellLine denotes HEK CVCL:M624
1459 2588-2596 CellLine denotes HEK-293T CVCL:0063
1469 9708-9715 Gene denotes Clade B
1482 10015-10018 Gene denotes DOR Gene:58476
1483 10161-10165 Gene denotes Iba1 Gene:199
1484 10167-10209 Gene denotes ionized calcium-binding adapter molecule 1 Gene:199
1485 10211-10216 Gene denotes JAM-1 Gene:50848
1486 10218-10248 Gene denotes junctional adhesion molecule-1 Gene:50848
1487 10250-10254 Gene denotes KCC2 Gene:57468
1488 10256-10278 Gene denotes K+-Cl− cotransporter 2 Gene:57468
1489 10280-10283 Gene denotes KOR Gene:4986
1490 10285-10302 Gene denotes κ-opioid receptor Gene:4986
1491 10376-10379 Gene denotes MOR Gene:4988
1492 10381-10398 Gene denotes μ-opioid receptor Gene:4988
1493 10331-10334 Disease denotes ΔΨm
1497 10929-10932 Species denotes HIV Tax:12721
1498 11059-11062 Species denotes HIV Tax:12721
1499 11174-11177 Species denotes HIV Tax:12721
1501 325-328 Species denotes HIV Tax:12721

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T48 1357-1366 http://purl.obolibrary.org/obo/GO_0016236 denotes Autophagy
T49 1357-1366 http://purl.obolibrary.org/obo/GO_0006914 denotes Autophagy
T50 1752-1762 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T51 2144-2161 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T52 2850-2874 http://purl.obolibrary.org/obo/GO_0030182 denotes neuronal differentiation
T53 3558-3571 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T54 4270-4282 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T55 4348-4357 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T56 5871-5880 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T57 6444-6455 http://purl.obolibrary.org/obo/GO_0042592 denotes Homeostasis
T58 6986-7003 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T59 7028-7045 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T60 7256-7260 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T61 7294-7300 http://purl.obolibrary.org/obo/GO_0016538 denotes Cyclin
T62 7399-7416 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T63 7421-7438 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T64 8333-8350 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T65 8550-8567 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T66 8955-8968 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T67 8959-8968 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T68 9007-9020 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T69 9011-9020 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T421 0-116 Sentence denotes Prior reviews have outlined how opiate drugs likely exacerbate neuroHIV pathology in neurons and glia (Hauser et al.
T422 117-156 Sentence denotes 2005; Dutta and Roy 2012; Hauser et al.
T423 157-175 Sentence denotes 2012; Reddy et al.
T424 176-215 Sentence denotes 2012; Hauser and Knapp 2014; Liu et al.
T425 216-236 Sentence denotes 2016a; Murphy et al.
T426 237-310 Sentence denotes 2019) including in the enteric nervous system (Galligan 2015; Meng et al.
T427 311-317 Sentence denotes 2015).
T428 318-607 Sentence denotes Opioid-HIV pathophysiological interactions are complex and differ depending on the timing and duration of co-exposure, the pharmacology of the opioid drug involved, the cell types and brain regions targeted, host and viral genetics, and are highly contextual (Hauser and Knapp 2014, 2018).
T429 608-725 Sentence denotes A summary of the cellular and molecular interactions in various CNS cell types is also reviewed in detail in Table 2.
T430 726-780 Sentence denotes Table 2 Cellular and molecular interactions (in vitro)
T431 781-864 Sentence denotes Major effects HIV pathogena ARV Opioids Outcome Model system (in vitro) Citation(s)
T432 865-875 Sentence denotes Mixed-Glia
T433 876-909 Sentence denotes HIV expression HIV No • Dynorphin
T434 910-919 Sentence denotes • U50,488
T435 920-956 Sentence denotes (KOR agonists) • ↑ HIV-1 expression,
T436 957-1087 Sentence denotes • Dynorphin (KOR agonist) ↑ TNF-α, IL-6 mRNA and protein Human fetal neural cells, HIV-infected promonocyte (U1) line (Chao et al.
T437 1088-1093 Sentence denotes 1995)
T438 1094-1115 Sentence denotes HIVSF162 No • U50,488
T439 1116-1125 Sentence denotes • U69,593
T440 1126-1142 Sentence denotes • Dynorphin1–17;
T441 1143-1157 Sentence denotes (KOR agonists)
T442 1158-1267 Sentence denotes • Morphine • KOR agonists ± TNF-α differentially ↓ HIV p24 Human, primary mixed neurons and glia (Chao et al.
T443 1268-1274 Sentence denotes 1998a)
T444 1275-1320 Sentence denotes Chemokines Tat1–86 No Morphine • ↑ CCL5, CCL2
T445 1321-1352 Sentence denotes • ↑ [Ca2+]i (Beclin1 dependent)
T446 1353-1409 Sentence denotes • ↓ Autophagy Mouse, primary mixed glia (Lapierre et al.
T447 1410-1415 Sentence denotes 2018)
T448 1416-1478 Sentence denotes HIVSF162 (R5) No Morphine • ↑ HIV-1 Tat-induced LTR expression
T449 1479-1543 Sentence denotes • ↑ CCR5 expression (inhibited by bivalent ligand in astrocytes)
T450 1544-1552 Sentence denotes • ↑ IL-6
T451 1553-1603 Sentence denotes • ↑ CCL5 Human, primary mixed glia (El-Hage et al.
T452 1604-1609 Sentence denotes 2013)
T453 1610-1794 Sentence denotes Glial restricted precursors: survival & MOR, DOR, KOR expression Tat1–72 No Morphine (acting via DOR and/or KOR) • ↑ Caspase-3 activation & ↑ cell death by Tat or morphine via DOR, KOR
T454 1795-1868 Sentence denotes • No opioid-Tat interactions Mouse, primary glial precursors (Buch et al.
T455 1869-1874 Sentence denotes 2007)
T456 1875-1898 Sentence denotes MOR expression in NPCs;
T457 1899-1989 Sentence denotes NPC survival and developmental fate Tat1–72 No Morphine • MOR expressed by subsets of NPCs
T458 1990-2072 Sentence denotes • ↑ Astrocyte and immature glial death Mouse, primary mixed glia (Khurdayan et al.
T459 2073-2078 Sentence denotes 2004)
T460 2079-2261 Sentence denotes MOR and CCR5 interactions Tat1–86 (from HIVIIIB) No Morphine • ↓ Neuronal survival via CCR5 activation in glia (rescued by BDNF treatment) Mouse, primary neurons and glia (Kim et al.
T461 2262-2267 Sentence denotes 2018)
T462 2268-2331 Sentence denotes HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine
T463 2332-2454 Sentence denotes CCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine
T464 2455-2615 Sentence denotes • MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al.
T465 2616-2635 Sentence denotes 2013; Arnatt et al.
T466 2636-2641 Sentence denotes 2016)
T467 2642-2789 Sentence denotes HIV expression and maturational fate of neurons and astroglia HIVBaL (R5) No Morphine • ↑ HIV p24 and ↑ Tat mRNA levels with morphine after 21 days
T468 2790-2917 Sentence denotes • ↓ Proliferation of neural progenitors; ↑ astroglial and ↑ neuronal differentiation Human, neural progenitors (Balinang et al.
T469 2918-2923 Sentence denotes 2017)
T470 2924-2934 Sentence denotes Astrocytes
T471 2935-2987 Sentence denotes HIV expression HIVSF162 (R5) No Morphine • ↑ HIV p24
T472 2988-3040 Sentence denotes • ↑ CCL2 Human, primary astrocytes (Rodriguez et al.
T473 3041-3046 Sentence denotes 2017)
T474 3047-3101 Sentence denotes Toll-like receptor (TLR) expression/function • Tat1–72
T475 3102-3162 Sentence denotes • gp120 No Morphine • ↑ TLR2 with Tat, Tat + morphine, gp120
T476 3163-3239 Sentence denotes • ↓ TLR9 with Tat, morphine, gp120 Mouse, primary astrocytes (El-Hage et al.
T477 3240-3246 Sentence denotes 2011a)
T478 3247-3292 Sentence denotes Chemokines Tat1–72 No Morphine • ↑ CCL5, CCL2
T479 3293-3301 Sentence denotes • ↑ IL-6
T480 3302-3355 Sentence denotes • ↑ [Ca2+]i Mouse, primary astrocytes (El-Hage et al.
T481 3356-3361 Sentence denotes 2005)
T482 3362-3390 Sentence denotes Tat1–72 No Morphine • ↑ CCL2
T483 3391-3399 Sentence denotes • ↑ CCL5
T484 3400-3466 Sentence denotes • ↑ Microglial migration Mouse, primary astrocytes (El-Hage et al.
T485 3467-3473 Sentence denotes 2006a)
T486 3474-3519 Sentence denotes Tat1–72 No Morphine • ↑ CCL2, ↑ IL-6, ↑ TNF-α
T487 3520-3531 Sentence denotes • ↑ [Ca2+]i
T488 3532-3571 Sentence denotes • ↑ NF-κB trafficking and transcription
T489 3572-3659 Sentence denotes • No interaction / acceleration with morphine Mouse, primary astrocytes (El-Hage et al.
T490 3660-3666 Sentence denotes 2008b)
T491 3667-3697 Sentence denotes Tat No • U50,488 (KOR agonist)
T492 3698-3741 Sentence denotes • Nor-BNI (KOR antagonist) • U50,488 ↓ CCL2
T493 3742-3799 Sentence denotes • U50,488 ↓ NF-κB Human, primary astrocytes (Sheng et al.
T494 3800-3805 Sentence denotes 2003)
T495 3806-3843 Sentence denotes N/A No Morphine • ↑ CCR5, CCR3, CXCR2
T496 3844-3927 Sentence denotes • ↓ IL-8, CCL4 Human, astrocytoma U87 cell line, primary astrocytes (Mahajan et al.
T497 3928-3933 Sentence denotes 2002)
T498 3934-3943 Sentence denotes • Tat1–86
T499 3944-4087 Sentence denotes • gp120IIIB No Morphine Regional differences in cytokine and ROS production —differed for each insult Mouse, primary astrocytes (Fitting et al.
T500 4088-4094 Sentence denotes 2010a)
T501 4095-4139 Sentence denotes Oxidative stress / damage Tat1–72 No • DPDPE
T502 4140-4148 Sentence denotes • SNC-80
T503 4149-4263 Sentence denotes (DOR agonists) DOR agonists ↓ Tat-induced oxidative stress Human derived brain cell line (SK-N-SH) (Wallace et al.
T504 4264-4269 Sentence denotes 2006)
T505 4270-4314 Sentence denotes Inflammation, maturation /plasticity • Tat86
T506 4315-4476 Sentence denotes • Tat101 No Morphine ↓ β-catenin signaling and variably decreases TrkB, BDNF, and NLRP1 mRNA in fetal astrocytes b Human, U87MG and fetal astrocytes (Chen et al.
T507 4477-4482 Sentence denotes 2020)
T508 4483-4492 Sentence denotes Microglia
T509 4493-4541 Sentence denotes HIV replication HIVSF162 (R5) No • Endomorphin-1
T510 4542-4557 Sentence denotes • Endomorphin-2
T511 4558-4626 Sentence denotes (MOR agonists) • ↑ HIV p24 with endomorphin-1, but not endomorphin-2
T512 4627-4716 Sentence denotes • Endomorphin-1 acts via MOR, but not DOR / KOR Human, primary microglia (Peterson et al.
T513 4717-4722 Sentence denotes 1999)
T514 4723-4799 Sentence denotes HIVSF162 (R5) No Morphine ↑ HIV p24 Human, primary microglia (El-Hage et al.
T515 4800-4805 Sentence denotes 2014)
T516 4806-4856 Sentence denotes HIVSF162 (R5) No • U50,488; U69,593 (KOR agonists)
T517 4857-4922 Sentence denotes • Dynorphin Al-13 ↓ HIV p24 Human, primary microglia (Chao et al.
T518 4923-4929 Sentence denotes 1996b)
T519 4930-4945 Sentence denotes • HIVJR-FL (R5)
T520 4946-4987 Sentence denotes • gp120 No β-endorphin • ↑ HIV expression
T521 4988-5023 Sentence denotes • ↑ HIV p24 (14-day post infection)
T522 5024-5087 Sentence denotes • gp120 ↑ IL-1, TNF, IL-6 Human, fetal microglia (Sundar et al.
T523 5088-5093 Sentence denotes 1995)
T524 5094-5137 Sentence denotes HIVSF162 No • 8-CAC, U50,488 (KOR agonists)
T525 5138-5195 Sentence denotes • Cocaine • KOR agonist ↓ p24; blocked by KOR antagonists
T526 5196-5283 Sentence denotes • KOR agonist negates cocaine-induced ↑ HIV Human, fetal brain microglia (Gekker et al.
T527 5284-5289 Sentence denotes 2004)
T528 5290-5317 Sentence denotes HIVSF162 No OPRL1 antisense
T529 5318-5394 Sentence denotes Nociceptin / orphanin FQ (OPRL1 agonist) • OPRL1 antisense (and sense) ↓ p24
T530 5395-5490 Sentence denotes • Nociceptin, no effect on p24 Human, fetal brain microglia and mixed neurons/glia (Chao et al.
T531 5491-5497 Sentence denotes 1998b)
T532 5498-5523 Sentence denotes HIV expression • HIVSF162
T533 5524-5586 Sentence denotes • Tat ZDV U50,488 (KOR agonist) • ↓ p24 on day 14 with U50,488
T534 5587-5614 Sentence denotes • ↓ Neurotoxicity (U50,488)
T535 5615-5696 Sentence denotes • ↓ Quinolinate by microglia Human, fetal microglia and neural cells (Chao et al.
T536 5697-5702 Sentence denotes 2000)
T537 5703-5756 Sentence denotes Chemokines and Cytokines Tat1–72 No Morphine • ↑ CCR5
T538 5757-5774 Sentence denotes • ↑ CD11b, ↑ CD40
T539 5775-5801 Sentence denotes • ↑ TNF-α, ↑ IL-6, ↑ IP-10
T540 5802-5860 Sentence denotes • ↑ iNOS Mouse, BV-2 and primary microglia (Bokhari et al.
T541 5861-5866 Sentence denotes 2009)
T542 5867-5924 Sentence denotes MOR signaling Tat1–72 No Morphine • ↑ MOR (intracellular)
T543 5925-5993 Sentence denotes • ↑ MOR mRNA Mouse, N9 and primary microglia (Turchan-Cholewo et al.
T544 5994-5999 Sentence denotes 2008)
T545 6000-6076 Sentence denotes Oxidative Stress Tat1–72 No Morphine • ↑ ROS [O2− (DHE), ↑ HO2•, H2O2 (DCF)]
T546 6077-6154 Sentence denotes • ↑ Protein carbonyls Mouse, N9 and primary microglia (Turchan-Cholewo et al.
T547 6155-6160 Sentence denotes 2009)
T548 6161-6316 Sentence denotes Glutamate release Tat1–72 No Morphine ↑ Glutamate release via ↑ xc− cystine-glutamate antiporter expression/function Mouse, primary microglia (Gupta et al.
T549 6317-6322 Sentence denotes 2010)
T550 6323-6330 Sentence denotes Neurons
T551 6331-6437 Sentence denotes HIV expression HIV No Morphine ↑ HIV expression Human derived, SH-SY5Y neuroblastoma cells (Squinto et al.
T552 6438-6443 Sentence denotes 1990)
T553 6444-6499 Sentence denotes Homeostasis and Injury Tat1–86 No Morphine • ↑ [Ca2+]i,
T554 6500-6510 Sentence denotes • ↑ [Na+]i
T555 6511-6546 Sentence denotes • ↓ ΔΨm (mitochondrial) instability
T556 6547-6612 Sentence denotes • ↑ Dendritic degeneration Mouse, primary neurons (Fitting et al.
T557 6613-6619 Sentence denotes 2014a)
T558 6620-6685 Sentence denotes Mitochondrial inner membrane potential and ROS • Tat1–86, Tat1–72
T559 6686-6960 Sentence denotes • gp120 No Morphine ↑ ΔΨm instability and oxidative stress ↑ with Tat + morphine, ↑ neuroprotection with allopregnanolone Human, primary neurons ; mouse, striatal medium spiny neurons; mouse, striatal medium spiny neurons, SH-SY5Y neuroblastoma cells (Turchan-Cholewo et al.
T560 6961-6979 Sentence denotes 2006; Paris et al.
T561 6980-6985 Sentence denotes 2020)
T562 6986-7101 Sentence denotes Neuronal survival Tat1–86 No Morphine • ↓ Neuronal survival from Tat + morphine and ↓ glial CX3CL1 rescued by CX3CL
T563 7102-7207 Sentence denotes • CX3CL1 (fractalkine) regulates microglial motility Mouse, primary neurons and mixed glia (Suzuki et al.
T564 7208-7213 Sentence denotes 2011)
T565 7214-7251 Sentence denotes Tat1–86 No Morphine • ↓ Proliferation
T566 7252-7273 Sentence denotes • ↑ ERK1/2 activation
T567 7274-7289 Sentence denotes • ↑ p53 and p21
T568 7290-7359 Sentence denotes • ↓ Cyclin D1 and Akt levels Human, neuronal precursors (Malik et al.
T569 7360-7365 Sentence denotes 2014)
T570 7366-7416 Sentence denotes Tat1–72, Tat1–86 No Morphine • ↓ Neuronal survival
T571 7417-7576 Sentence denotes • ↑ Neuronal survival with ibudilast (AV411) (inhibiting glial NF-κB blocks Tat ± morphine neurotoxicity) Mouse, primary neurons and mixed glia (Gurwell et al.
T572 7577-7597 Sentence denotes 2001; El-Hage et al.
T573 7598-7603 Sentence denotes 2014)
T574 7604-7643 Sentence denotes White matter/oligodendroglial pathology
T575 7644-7769 Sentence denotes Changes in OL survival and morphology Tat1–86 No Morphine (25 mg pellet, 7 days); morphine (in vitro) • ↑ Degeneration of OLs
T576 7770-7790 Sentence denotes • ↑ TUNEL reactivity
T577 7791-7857 Sentence denotes • ↑ Caspase-3 activation Mouse, Tat tg; primary OLs (Hauser et al.
T578 7858-7863 Sentence denotes 2009)
T579 7864-7910 Sentence denotes Blood-brain barrier and the neurovascular unit
T580 7911-7973 Sentence denotes BBB model integrity and function Tat1–86 No Morphine • ↑ TNF-α
T581 7974-7982 Sentence denotes • ↑ IL-8
T582 7983-7990 Sentence denotes • ↓TEER
T583 7991-8011 Sentence denotes • ↑ JAM-2 expression
T584 8012-8115 Sentence denotes • ↑ Monocyte transmigration with CCL5 Human, using primary BMVEC and primary astrocytes (Mahajan et al.
T585 8116-8121 Sentence denotes 2008)
T586 8122-8150 Sentence denotes ARV accumulation Tat1–86 DTG
T587 8151-8154 Sentence denotes FTC
T588 8155-8244 Sentence denotes TFV Morphine • ↓ Intracellular ARV concentrations Human, primary astrocytes (Patel et al.
T589 8245-8250 Sentence denotes 2019)
T590 8251-8275 Sentence denotes HIV-1 strain differences
T591 8276-8372 Sentence denotes Neuronal Survival Tat1–86 (clades B & C) No Morphine • ↓ Neuronal survival via MOR on mixed glia
T592 8373-8394 Sentence denotes • ↑ ROS in astrocytes
T593 8395-8486 Sentence denotes • ↑ Iba1 and 3-NT microglia with morphine Mouse, primary neurons and mixed glia (Zou et al.
T594 8487-8492 Sentence denotes 2011)
T595 8493-8504 Sentence denotes • gp120IIIB
T596 8505-8519 Sentence denotes • gp120MN (X4)
T597 8520-8743 Sentence denotes • gp120ADA (R5) No Morphine ↓ Neuronal survival in presence of glia with gp120MN and transiently with gp120IIIB (X4), not R5-tropic gp120, in combination with morphine Mouse, primary neurons and mixed glia (Podhaizer et al.
T598 8744-8749 Sentence denotes 2012)
T599 8750-8843 Sentence denotes Proliferation and maturational fate of neural progenitors and oligodendroglia • HIVSF162 (R5)
T600 8844-8946 Sentence denotes • HIVIIIB (X4) No Morphine • ↓ Proliferation of immature neural and OL progenitors with Tat + morphine
T601 8947-8998 Sentence denotes • ↓ NPC DNA synthesis with R5-tropic HIV + morphine
T602 8999-9119 Sentence denotes • ↑ NPC DNA synthesis with X4-tropic HIV + morphine Mouse, Tat tg; Mouse, Human, primary neural progenitors (Hahn et al.
T603 9120-9125 Sentence denotes 2012)
T604 9126-9153 Sentence denotes GABA function • HIVBaL (R5)
T605 9154-9181 Sentence denotes • gp120 (ADA, MN, and IIIB)
T606 9182-9244 Sentence denotes • Tat1–86 No Morphine • Tat or morphine ↓ KCC2 levels via CCR5
T607 9245-9374 Sentence denotes • ↑ KCC2 prevents Tat and R5 HIV, gp120, but not X4, gp120 neurotoxicity ± morphine Human, primary neurons, hNPCs (Barbour et al.
T608 9375-9380 Sentence denotes 2020)
T609 9381-9433 Sentence denotes Astroglial CCL5 and neuroprotection • gp120IIIB (X4)
T610 9434-9471 Sentence denotes • gp120BaL (R5) No • Morphine (10 μM)
T611 9472-9540 Sentence denotes • DAMGO • Morphine ↑ astroglial CCL5 blocking gp120BaL neurotoxicity
T612 9541-9692 Sentence denotes • Morphine (or CXCL12) does not block gp120IIIB neurotoxicity Rat, mixed neurons and glia; isolated neurons, astrocytes and microglia (Avdoshina et al.
T613 9693-9698 Sentence denotes 2010)
T614 9699-9792 Sentence denotes aassumed Clade B, unless noted otherwise, b statistical findings for some results are unclear
T615 9793-10703 Sentence denotes ARV, antiretroviral(s); BMVEC, brain vascular endothelial cells; [Ca2+]i intracellular calcium concentration; 8-CAC, 8-carboxamidocyclazocine; DAMGO, D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DCF, dihydro-dichlorofluorescein; DOR, δ-opioid receptor; DHE, dihydroethidium; DTG, dolutegravir; DPDPE, [D-Pen2,D-Pen5]enkephalin; FTC, emtricitabine; GABA, γ-aminobutyric acid; Iba1, ionized calcium-binding adapter molecule 1; JAM-1, junctional adhesion molecule-1; KCC2, K+-Cl− cotransporter 2; KOR, κ-opioid receptor; LTR, long terminal repeat; ΔΨm, mitochondrial inner membrane potential; MOR, μ-opioid receptor; [Na+]i, intracellular sodium concentration; nor-BNI, nor-binaltorphimine; NPCs, neural progenitor cells; OLs, oligodendroglia; ROS, reactive oxygen species; TEER, transendothelial electrical resistance; TFV, tenofovir; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; ZDV, zidovudine
T616 10704-10853 Sentence denotes For practicality, the table is limited to key studies in the CNS with emphasis on neuropathological or neuroimmune rather than psychosocial outcomes.
T617 10854-11261 Sentence denotes With deference toward the excellent studies we excluded: (1) on opioid and HIV effects on PBMCs, or on isolated lymphocytes and monocytes, not directly related to the central nervous system or BBB; (2) on HIV or opioid and ARV interactions in the peripheral nervous system; and (3) studies not directly examining opioid-HIV interactions (irrespective of whether a positive or negative interaction was found)

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T39 3866-3877 Phenotype denotes astrocytoma http://purl.obolibrary.org/obo/HP_0009592
T40 4095-4111 Phenotype denotes Oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T41 4191-4207 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T42 6000-6016 Phenotype denotes Oxidative Stress http://purl.obolibrary.org/obo/HP_0025464
T43 6402-6415 Phenotype denotes neuroblastoma http://purl.obolibrary.org/obo/HP_0003006
T44 6728-6744 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T45 6917-6930 Phenotype denotes neuroblastoma http://purl.obolibrary.org/obo/HP_0003006

2_test

Id Subject Object Predicate Lexical cue
32876803-16260386-62958031 117-121 16260386 denotes 2005
32876803-22591371-62958032 137-141 22591371 denotes 2012
32876803-22591368-62958033 157-161 22591368 denotes 2012
32876803-22666564-62958034 176-180 22666564 denotes 2012
32876803-25175867-62958035 199-203 25175867 denotes 2014
32876803-31681322-62958037 237-241 31681322 denotes 2019
32876803-25817054-62958038 293-297 25817054 denotes 2015
32876803-26167159-62958039 311-315 26167159 denotes 2015
32876803-25175867-62958040 595-599 25175867 denotes 2014
32876803-29410949-62958041 601-605 29410949 denotes 2018
32876803-7668162-62958042 1088-1092 7668162 denotes 1995
32876803-23682308-62958043 2616-2620 23682308 denotes 2013
32876803-27720326-62958044 2636-2640 27720326 denotes 2016
32876803-28099189-62958045 2918-2922 28099189 denotes 2017
32876803-16168488-62958046 4264-4268 16168488 denotes 2006
32876803-10218868-62958047 4717-4721 10218868 denotes 1999
32876803-24732776-62958048 4800-4804 24732776 denotes 2014
32876803-7560019-62958050 5088-5092 7560019 denotes 1995
32876803-14757849-62958051 5284-5288 14757849 denotes 2004
32876803-10665828-62958053 5697-5701 10665828 denotes 2000
32876803-2252636-62958054 6438-6442 2252636 denotes 1990
32876803-16697650-62958055 6961-6965 16697650 denotes 2006
32876803-24469921-62958056 7360-7364 24469921 denotes 2014
32876803-24732776-62958057 7598-7602 24732776 denotes 2014
32876803-18756534-62958058 7858-7862 18756534 denotes 2009
32876803-22101471-62958059 8744-8748 22101471 denotes 2012
32876803-22865725-62958060 9120-9124 22865725 denotes 2012
32876803-20578038-62958061 9693-9697 20578038 denotes 2010