PMC:7463108 / 1529-1928
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T64264 | 20-25 | Body_part | denotes | Blood | http://purl.org/sig/ont/fma/fma9670 |
| T26336 | 26-31 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T43402 | 73-76 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T14505 | 159-173 | Body_part | denotes | tight junction | http://purl.org/sig/ont/fma/fma67397 |
| T96043 | 174-182 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T51030 | 240-245 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T69233 | 363-368 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T4 | 20-39 | Body_part | denotes | Blood-brain barrier | http://purl.obolibrary.org/obo/UBERON_0000120 |
| T5 | 26-31 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T6 | 240-245 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T7 | 363-368 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T47640 | 20-25 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | Blood |
| T18975 | 20-25 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | Blood |
| T73965 | 26-31 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T21933 | 26-31 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T54654 | 165-173 | http://purl.obolibrary.org/obo/UBERON_0007651 | denotes | junction |
| T9825 | 240-245 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T35601 | 240-245 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T50159 | 363-368 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T45065 | 363-368 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 174-182 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T2 | 393-398 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 24 | 317-341 | Gene | denotes | some efflux transporters | |
| 25 | 73-76 | Species | denotes | HIV | Tax:12721 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T85650 | 146-155 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | breakdown |
| T12576 | 322-328 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
| T35890 | 322-328 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 0-67 | Sentence | denotes | Graphical Abstract Blood-brain barrier and the neurovascular unit. |
| T11 | 68-246 | Sentence | denotes | With HIV and opiate co-exposure (represented below the dotted line), there is breakdown of tight junction proteins and increased leakage of paracellular compounds into the brain. |
| T12 | 247-399 | Sentence | denotes | Despite this, opiate exposure selectively increases the expression of some efflux transporters, thereby restricting brain penetration of specific drugs. |