> top > docs > PMC:7463108 > spans > 12385-29719 > annotations

PMC:7463108 / 12385-29719 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T9482 77-80 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T12354 140-143 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T67899 328-331 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T43924 408-411 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T52247 808-813 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T7491 1561-1564 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T33611 1587-1592 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T479 1672-1675 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T92463 2161-2164 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T48606 2263-2267 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T1997 2819-2822 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T9687 2960-2963 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T82777 3284-3287 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T78472 3339-3342 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T58755 3380-3384 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T34298 3949-3953 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T62955 4134-4137 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T46418 4408-4411 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T35666 4464-4467 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T82002 4559-4562 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T12185 4644-4647 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T88 4681-4684 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T89 4848-4851 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T90 4952-4955 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T91 5028-5031 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T92 5052-5055 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T93 5066-5069 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T94 5070-5073 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T95 5127-5132 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T96 5137-5140 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T97 5163-5168 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T98 5210-5213 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T99 5275-5278 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T100 5302-5307 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T101 5328-5331 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T102 5441-5444 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T103 5466-5469 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T104 5506-5511 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T105 5534-5537 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T106 5595-5598 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T107 5604-5607 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T108 5671-5676 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T109 5696-5702 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T110 5703-5712 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T111 5713-5716 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T112 5797-5803 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T113 5829-5832 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T114 5892-5897 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T115 5952-5957 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T116 5993-5996 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T117 6054-6057 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T118 6103-6108 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T119 6159-6162 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T120 6303-6306 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T121 6371-6374 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T122 6502-6505 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T123 6593-6596 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T124 6698-6704 Body_part denotes Concha http://purl.org/sig/ont/fma/fma61006
T125 6836-6839 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T126 6999-7002 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T127 7061-7064 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T128 7130-7133 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T129 7233-7236 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T130 7336-7339 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T131 7396-7399 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T132 7481-7484 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T133 7592-7595 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T134 7620-7626 Body_part denotes Finger http://purl.org/sig/ont/fma/fma9666
T135 7711-7714 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T136 7811-7814 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T137 7859-7862 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T138 7874-7877 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T139 7890-7893 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T140 7964-7969 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T141 8028-8031 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T142 8168-8171 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T143 8215-8218 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T144 8277-8280 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T145 8410-8415 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T146 8464-8467 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T147 8519-8522 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T148 8600-8603 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T149 8613-8616 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T150 8753-8756 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T151 8772-8777 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T152 8872-8875 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T153 9035-9040 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T154 9045-9048 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T155 9094-9099 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T156 9154-9157 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T157 9394-9398 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T158 9935-9938 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T159 10159-10167 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T160 10209-10212 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T161 10391-10394 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T162 10431-10437 Body_part denotes neuron http://purl.org/sig/ont/fma/fma54527
T163 10447-10450 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T164 10470-10473 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T165 10509-10512 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T166 10583-10587 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T167 10635-10641 Body_part denotes neuron http://purl.org/sig/ont/fma/fma54527
T168 10681-10691 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T169 10723-10730 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T170 10732-10742 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T171 11043-11050 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 11071-11075 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T173 11133-11138 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T174 11171-11183 Body_part denotes White matter http://purl.org/sig/ont/fma/fma83929
T175 11290-11301 Body_part denotes Macrophages http://purl.org/sig/ont/fma/fma63261
T176 11314-11320 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T177 11366-11369 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T178 11497-11509 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T179 11536-11548 Body_part denotes Myo-inositol http://purl.org/sig/ont/fma/fma82800
T180 11552-11559 Body_part denotes putamen http://purl.org/sig/ont/fma/fma61834
T181 11680-11689 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T182 11729-11739 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T183 11827-11837 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T184 11871-11882 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T185 11883-11892 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T186 11985-11994 Body_part denotes Cytokines http://purl.org/sig/ont/fma/fma84050
T187 11996-12006 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T188 12007-12010 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T189 12183-12192 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T190 12237-12240 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T191 12271-12275 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T192 12282-12285 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T193 12342-12352 Body_part denotes G proteins http://purl.org/sig/ont/fma/fma61788
T194 12450-12453 Body_part denotes NAc http://purl.org/sig/ont/fma/fma61889
T195 12466-12474 Body_part denotes amygdala http://purl.org/sig/ont/fma/fma61841
T196 12489-12500 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T197 12777-12786 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T198 13021-13025 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T199 13940-13945 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T200 13946-13951 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T201 14012-14016 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T202 14034-14037 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T203 14074-14083 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T204 14090-14095 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T205 14124-14127 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T206 14148-14152 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T207 14200-14203 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T208 14776-14781 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T209 14782-14787 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T210 14847-14854 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T211 14871-14878 Body_part denotes putamen http://purl.org/sig/ont/fma/fma61834
T212 14880-14883 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T213 14885-14907 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T214 14968-14971 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T215 14973-14992 Body_part denotes cerebrospinal fluid http://purl.org/sig/ont/fma/fma20935
T216 15027-15037 Body_part denotes enkephalin http://purl.org/sig/ont/fma/fma83367
T217 15053-15070 Body_part denotes dopamine receptor http://purl.org/sig/ont/fma/fma61811
T218 15097-15100 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T219 15166-15173 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T220 15317-15320 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T221 15554-15571 Body_part denotes prefrontal cortex http://purl.org/sig/ont/fma/fma224850
T222 15846-15849 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T223 16010-16013 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T224 16025-16059 Body_part denotes peripheral blood mononuclear cells http://purl.org/sig/ont/fma/fma86713
T225 16054-16059 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T226 16084-16095 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T227 16100-16109 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T228 16139-16161 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T229 16177-16180 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T230 16219-16244 Body_part denotes peripheral nervous system http://purl.org/sig/ont/fma/fma9903
T231 16292-16295 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T232 16635-16638 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T233 16668-16671 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T234 16775-16778 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T235 16839-16850 Body_part denotes neural cell http://purl.org/sig/ont/fma/fma70333
T236 16846-16850 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T237 16947-16958 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T238 17089-17092 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T239 17102-17110 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T240 17162-17165 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T241 17166-17170 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T242 17188-17195 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T243 17212-17221 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T27 140-143 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T28 4134-4137 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T29 4464-4467 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T30 5066-5069 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T31 5163-5168 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T32 5302-5307 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T33 5506-5511 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T34 5671-5676 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T35 5892-5897 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T36 6103-6108 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T37 7620-7626 Body_part denotes Finger http://purl.obolibrary.org/obo/UBERON_0002389
T38 7964-7969 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T39 8410-8415 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T40 8772-8777 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T41 9094-9099 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T42 11171-11183 Body_part denotes White matter http://purl.obolibrary.org/obo/UBERON_0002316
T43 11314-11320 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T44 11366-11369 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T45 11497-11509 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T46 11552-11559 Body_part denotes putamen http://purl.obolibrary.org/obo/UBERON_0001874
T47 12450-12453 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T48 12454-12459 Body_part denotes Shell http://purl.obolibrary.org/obo/UBERON_0006612
T49 12466-12474 Body_part denotes amygdala http://purl.obolibrary.org/obo/UBERON_0001876
T50 13179-13183 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T51 13940-13959 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T52 13940-13945 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T53 13946-13951 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T54 14034-14037 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T55 14124-14127 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T56 14200-14203 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T57 14776-14795 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T58 14776-14781 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T59 14782-14787 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T60 14863-14878 Body_part denotes caudate-putamen http://purl.obolibrary.org/obo/UBERON_0005383
T61 14871-14878 Body_part denotes putamen http://purl.obolibrary.org/obo/UBERON_0001874
T62 14880-14883 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T63 14885-14907 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T64 14893-14907 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T65 14973-14992 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359
T66 15554-15571 Body_part denotes prefrontal cortex http://purl.obolibrary.org/obo/UBERON_0000451
T67 15565-15571 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T68 15846-15849 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T69 16036-16041 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T70 16139-16161 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T71 16147-16161 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T72 16219-16244 Body_part denotes peripheral nervous system http://purl.obolibrary.org/obo/UBERON_0000010
T73 16230-16244 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T74 16668-16671 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T75 17162-17165 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T20 467-490 Disease denotes peripheral neuropathies http://purl.obolibrary.org/obo/MONDO_0003620
T21 1075-1093 Disease denotes immune suppression http://purl.obolibrary.org/obo/MONDO_0007816
T22 1446-1481 Disease denotes acquired immune deficiency syndrome http://purl.obolibrary.org/obo/MONDO_0012268
T23 1483-1487 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T24 2668-2672 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T25 2819-2835 Disease denotes HIV encephalitis http://purl.obolibrary.org/obo/MONDO_0020689
T26 2823-2835 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T27 2837-2841 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T28 3180-3184 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T29 3221-3231 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T30 3236-3240 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T31 3284-3307 Disease denotes HIV-associated dementia http://purl.obolibrary.org/obo/MONDO_0020689
T32 3299-3307 Disease denotes dementia http://purl.obolibrary.org/obo/MONDO_0001627
T33 4103-4112 Disease denotes tauopathy http://purl.obolibrary.org/obo/MONDO_0005574
T34 4138-4150 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T35 5028-5044 Disease denotes HIV encephalitis http://purl.obolibrary.org/obo/MONDO_0020689
T36 5032-5044 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T37 5046-5050 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T38 5052-5065 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T39 5056-5065 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 5612-5616 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T41 5763-5765 Disease denotes R2 http://purl.obolibrary.org/obo/MONDO_0019903
T42 5988-5992 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T43 6253-6269 Disease denotes hypersensitivity http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271
T45 7850-7854 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T46 7883-7887 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T47 8321-8325 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T48 8387-8391 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T49 8581-8599 Disease denotes Sensory Neuropathy http://purl.obolibrary.org/obo/MONDO_0002321
T50 8589-8599 Disease denotes Neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T51 8617-8635 Disease denotes sensory neuropathy http://purl.obolibrary.org/obo/MONDO_0002321
T52 8625-8635 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T53 9313-9316 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T54 9390-9393 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T55 9584-9587 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T56 9761-9764 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T57 9887-9890 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T58 10059-10062 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T59 10168-10174 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T60 10505-10508 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T61 10617-10620 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T62 11028-11031 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T63 11119-11132 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T64 11511-11514 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T65 11596-11613 Disease denotes Neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T66 12098-12117 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T67 12108-12117 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T68 12568-12585 Disease denotes Neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T69 12893-12903 Disease denotes Neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T70 14104-14114 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T71 14204-14213 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72 14218-14228 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T73 15091-15095 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T74 15097-15113 Disease denotes HIV encephalitis http://purl.obolibrary.org/obo/MONDO_0020689
T75 15101-15113 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T76 16703-16712 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T58219 34-35 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41182 140-143 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T77891 140-143 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T63860 140-143 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T93692 808-813 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T68688 1537-1547 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T79627 1587-1592 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T33018 1841-1850 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T73862 2263-2272 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T23496 2294-2298 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T37874 2612-2616 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T54483 2935-2938 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T12730 2947-2948 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73274 3109-3112 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T70101 3140-3141 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22068 3246-3247 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T80547 3797-3801 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T72479 3816-3820 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T44553 4020-4023 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T1442 4134-4137 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T9138 4134-4137 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T36989 4134-4137 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T90278 4464-4467 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T48453 4464-4467 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T23922 4464-4467 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T93134 4637-4642 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T83255 4822-4827 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T23448 4925-4930 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T112 4987-4990 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T113 4998-5003 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T114 5066-5069 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T115 5066-5069 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T116 5066-5069 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T117 5127-5132 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T118 5145-5150 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T119 5163-5168 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T120 5163-5168 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T121 5199-5209 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T122 5232-5236 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T123 5248-5258 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T124 5284-5289 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T125 5302-5307 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T126 5302-5307 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T127 5405-5415 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T128 5416-5421 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T129 5483-5487 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T130 5488-5493 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T131 5506-5511 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T132 5506-5511 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T133 5566-5568 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T134 5589-5593 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T135 5648-5652 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T136 5653-5658 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T137 5671-5676 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T138 5671-5676 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T139 5696-5702 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T140 5790-5792 http://purl.obolibrary.org/obo/CLO_0008697 denotes R1
T141 5790-5792 http://purl.obolibrary.org/obo/CLO_0052381 denotes R1
T142 5797-5803 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T143 5804-5809 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T144 5892-5897 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T145 5892-5897 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T146 5948-5951 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T147 5952-5957 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T148 5958-5963 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T149 6085-6090 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T150 6103-6108 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T151 6103-6108 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T152 6326-6331 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T153 6468-6473 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T154 6475-6481 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T155 6568-6573 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T156 6691-6696 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T157 6787-6792 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T158 6947-6952 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T159 6967-6971 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T160 7176-7181 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T161 7197-7201 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T162 7359-7364 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T163 7446-7451 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T164 7539-7544 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T165 7612-7619 http://www.ebi.ac.uk/efo/EFO_0000881 denotes Digital
T166 7635-7639 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T167 7665-7670 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T168 7766-7771 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T169 7789-7793 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T170 7945-7950 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T171 7964-7969 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T172 7964-7969 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T173 8140-8145 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T174 8246-8251 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T175 8371-8374 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T176 8392-8397 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T177 8410-8415 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T178 8410-8415 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T179 8550-8555 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T180 8681-8686 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T181 8745-8751 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T182 8772-8777 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T183 8772-8777 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T184 8930-8945 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T185 9019-9022 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T186 9028-9031 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T187 9033-9040 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T188 9094-9099 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T189 9094-9099 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T190 9100-9115 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T191 9278-9281 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T192 9317-9332 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T193 9394-9398 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T194 9532-9535 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T195 9632-9647 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T196 9711-9714 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T197 9830-9833 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T198 10352-10357 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T199 10480-10486 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T200 10581-10582 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T201 10596-10598 http://purl.obolibrary.org/obo/CLO_0001869 denotes BB
T202 10630-10631 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T203 10681-10691 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T204 10692-10707 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T205 10732-10742 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T206 10847-10852 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T207 10854-10858 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T208 10854-10858 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T209 10863-10869 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T210 11087-11102 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T211 11104-11109 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T212 11111-11118 http://purl.obolibrary.org/obo/CLO_0009015 denotes SH-SY5Y
T213 11111-11118 http://purl.obolibrary.org/obo/CLO_0051795 denotes SH-SY5Y
T214 11111-11118 http://purl.obolibrary.org/obo/CLO_0052135 denotes SH-SY5Y
T215 11111-11118 http://purl.obolibrary.org/obo/CLO_0052139 denotes SH-SY5Y
T216 11111-11118 http://purl.obolibrary.org/obo/CLO_0052141 denotes SH-SY5Y
T217 11133-11147 http://purl.obolibrary.org/obo/CL_0001034 denotes cells in vitro
T218 11326-11341 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T219 11366-11369 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T220 11366-11369 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T221 11366-11369 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T222 11560-11575 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T223 11680-11689 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T224 11690-11695 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T225 11705-11710 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T226 11705-11710 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T227 11827-11837 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T228 11883-11892 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T229 11956-11961 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T230 12144-12148 http://purl.obolibrary.org/obo/CLO_0050768 denotes TLR2
T231 12161-12166 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T232 12168-12172 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T233 12168-12172 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T234 12183-12192 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T235 12291-12296 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T236 12291-12296 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T237 12528-12533 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T238 12543-12548 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T239 12543-12548 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T240 12852-12857 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T241 12867-12872 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T242 12867-12872 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T243 12887-12891 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T244 13031-13036 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T245 13031-13036 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T246 13062-13066 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T247 13179-13183 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T248 13191-13196 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T249 13206-13211 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T250 13206-13211 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T251 13371-13376 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T252 13386-13391 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T253 13386-13391 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T254 13516-13524 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T255 13547-13552 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T256 13554-13559 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T257 13569-13576 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T258 13699-13714 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T259 13809-13814 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T260 13824-13831 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T261 13940-13945 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T262 13940-13945 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T263 13946-13951 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T264 13946-13951 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T265 13960-13965 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T266 13974-13981 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T267 14012-14016 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T268 14034-14037 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T269 14034-14037 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T270 14034-14037 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T271 14074-14083 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T272 14088-14095 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T273 14124-14127 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T274 14124-14127 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T275 14124-14127 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T276 14146-14152 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T277 14193-14198 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T278 14200-14203 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T279 14200-14203 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T280 14200-14203 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T281 14231-14236 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T282 14231-14236 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T283 14396-14405 http://purl.obolibrary.org/obo/UBERON_0000955 denotes in brains
T284 14396-14405 http://www.ebi.ac.uk/efo/EFO_0000302 denotes in brains
T285 14426-14433 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T286 14434-14439 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T287 14448-14455 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T288 14567-14575 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T289 14576-14581 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T290 14591-14596 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T291 14591-14596 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T292 14633-14634 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T293 14660-14661 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T294 14699-14700 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T295 14776-14781 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T296 14776-14781 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T297 14782-14787 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T298 14782-14787 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T299 14811-14812 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T300 14880-14883 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T301 14880-14883 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T302 14880-14883 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T303 14885-14907 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T304 14885-14907 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T305 14885-14907 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T306 15053-15061 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T307 15174-15175 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T308 15565-15571 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T309 15608-15609 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T310 15634-15635 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T311 15756-15757 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T312 15846-15849 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T313 15846-15849 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T314 15846-15849 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T315 16025-16059 http://purl.obolibrary.org/obo/CL_0000842 denotes peripheral blood mononuclear cells
T316 16025-16059 http://purl.obolibrary.org/obo/CL_2000001 denotes peripheral blood mononuclear cells
T317 16100-16109 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T318 16139-16161 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T319 16139-16161 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T320 16139-16161 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T321 16219-16244 http://purl.obolibrary.org/obo/UBERON_0000010 denotes peripheral nervous system
T322 16219-16244 http://www.ebi.ac.uk/efo/EFO_0000891 denotes peripheral nervous system
T323 16334-16335 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T324 16668-16671 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T325 16668-16671 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T326 16668-16671 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T327 16726-16727 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 16846-16850 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T329 17162-17165 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T330 17162-17165 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T331 17162-17165 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T332 17166-17176 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T333 17212-17221 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T50 278-282 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T51 362-367 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T52 512-517 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T53 1365-1373 Chemical denotes cofactor http://purl.obolibrary.org/obo/CHEBI_23357
T54 1634-1636 Chemical denotes Ho http://purl.obolibrary.org/obo/CHEBI_49648
T55 2091-2094 Chemical denotes Guo http://purl.obolibrary.org/obo/CHEBI_16750
T56 2460-2469 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T57 2481-2489 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T59 2575-2583 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61 2893-2899 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T62 3016-3022 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T63 3562-3567 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T64 4800-4805 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T65 4976-4980 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T66 5085-5089 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T67 5375-5379 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T68 5476-5478 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T69 5555-5564 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T70 5727-5734 Chemical denotes codeine http://purl.obolibrary.org/obo/CHEBI_16714|http://purl.obolibrary.org/obo/CHEBI_57871
T72 5736-5744 Chemical denotes fentanyl http://purl.obolibrary.org/obo/CHEBI_119915
T73 5746-5754 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T75 5852-5858 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T76 5883-5886 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T78 5921-5924 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T81 6185-6192 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T83 6205-6212 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T85 6280-6288 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T86 6390-6396 Chemical denotes Heroin http://purl.obolibrary.org/obo/CHEBI_27808
T87 6404-6411 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T89 6520-6526 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T90 6619-6626 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T92 6639-6646 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T94 6759-6768 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T95 6880-6896 Chemical denotes anticholinergics http://purl.obolibrary.org/obo/CHEBI_48873
T96 6915-6926 Chemical denotes anxiolytics http://purl.obolibrary.org/obo/CHEBI_35474
T97 6931-6946 Chemical denotes anticonvulsants http://purl.obolibrary.org/obo/CHEBI_35623
T98 7013-7020 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T100 7022-7029 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T102 7031-7037 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T103 7164-7171 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T105 7257-7266 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T106 7321-7330 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T107 7437-7441 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T108 7511-7517 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T109 8092-8099 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T111 8101-8108 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T113 8824-8832 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T114 8983-8991 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T115 9217-9225 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T116 9293-9296 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T117 9302-9310 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T119 9468-9476 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T120 9623-9631 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T122 9779-9787 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T124 9905-9913 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T126 9944-9952 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T128 10108-10116 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T130 10221-10229 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T131 10259-10262 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T132 10325-10338 Chemical denotes Sphingomyelin http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_62490|http://purl.obolibrary.org/obo/CHEBI_89482|http://purl.obolibrary.org/obo/CHEBI_89483|http://purl.obolibrary.org/obo/CHEBI_89488|http://purl.obolibrary.org/obo/CHEBI_89490|http://purl.obolibrary.org/obo/CHEBI_89491
T139 10343-10351 Chemical denotes Ceramide http://purl.obolibrary.org/obo/CHEBI_17761
T140 10398-10406 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T141 10456-10464 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T143 10488-10491 Chemical denotes Guo http://purl.obolibrary.org/obo/CHEBI_16750
T144 10520-10528 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T145 10596-10598 Chemical denotes BB http://purl.obolibrary.org/obo/CHEBI_53109
T146 10604-10612 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T148 10664-10672 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T150 10793-10801 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T151 10854-10858 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T152 10871-10874 Chemical denotes PFC http://purl.obolibrary.org/obo/CHEBI_134091
T153 10941-10949 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T154 11008-11016 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T155 11043-11050 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T156 11111-11113 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T158 11209-11217 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T159 11370-11381 Chemical denotes metabolites http://purl.obolibrary.org/obo/CHEBI_25212
T160 11398-11406 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T161 11485-11493 Chemical denotes Creatine http://purl.obolibrary.org/obo/CHEBI_16919
T162 11517-11525 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T164 11540-11548 Chemical denotes inositol http://purl.obolibrary.org/obo/CHEBI_24848
T165 11625-11633 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T166 11783-11791 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T167 11916-11924 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T169 12034-12042 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T170 12072-12080 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T171 12128-12130 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T173 12168-12172 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T174 12344-12352 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T175 12366-12374 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T176 12400-12408 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T177 12410-12415 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T178 12433-12436 Chemical denotes GTP http://purl.obolibrary.org/obo/CHEBI_15996|http://purl.obolibrary.org/obo/CHEBI_37565
T180 12476-12479 Chemical denotes PFC http://purl.obolibrary.org/obo/CHEBI_134091
T181 12507-12515 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T183 12587-12595 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T185 12664-12672 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T186 12769-12772 Chemical denotes CPP http://purl.obolibrary.org/obo/CHEBI_34603
T187 12942-12950 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T188 13068-13076 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T189 13106-13114 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T190 13234-13242 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T191 13285-13293 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T192 13444-13453 Chemical denotes Oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T193 13619-13627 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T194 13749-13758 Chemical denotes Oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T195 13873-13881 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T196 14045-14053 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T197 14133-14141 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T199 14184-14192 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T201 14283-14286 Chemical denotes ABC http://purl.obolibrary.org/obo/CHEBI_421707
T202 14287-14290 Chemical denotes 3TC http://purl.obolibrary.org/obo/CHEBI_63577
T203 14291-14299 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T204 14358-14366 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T205 14385-14395 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T206 14409-14417 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T208 14508-14516 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T209 14732-14735 Chemical denotes ABC http://purl.obolibrary.org/obo/CHEBI_421707
T210 14737-14745 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T211 14847-14854 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T212 14909-14912 Chemical denotes CPP http://purl.obolibrary.org/obo/CHEBI_34603
T213 14994-14999 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T214 15019-15022 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T215 15053-15061 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T217 15077-15089 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T218 15166-15173 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T219 15194-15198 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T220 15264-15271 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T222 15288-15296 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T223 15300-15303 Chemical denotes 3TC http://purl.obolibrary.org/obo/CHEBI_63577
T224 15305-15315 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T225 15327-15329 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T226 15362-15364 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T227 15549-15552 Chemical denotes PFC http://purl.obolibrary.org/obo/CHEBI_134091
T228 15641-15644 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T229 15646-15669 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T230 15655-15661 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T231 15768-15778 Chemical denotes zidovudine http://purl.obolibrary.org/obo/CHEBI_10110
T232 17102-17110 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
228 1533-1536 Gene denotes MOR Gene:4988
229 1664-1667 Gene denotes MOR Gene:4988
230 1705-1709 Gene denotes CCR5 Gene:1234
231 1774-1779 Gene denotes CXCR4 Gene:7852
232 2021-2024 Gene denotes MOR Gene:4988
233 2025-2029 Gene denotes CCR5 Gene:1234
234 2033-2038 Gene denotes CXCR4 Gene:7852
235 2335-2338 Gene denotes Tat Gene:6898
236 2450-2454 Gene denotes CCR5 Gene:12774
237 2562-2565 Gene denotes Tat Gene:234724
238 333-337 Gene denotes Nath Gene:80155
240 1714-1718 Gene denotes Hage Gene:55510
241 56-62 Species denotes People Tax:9606
242 739-745 Species denotes Lemons Tax:2708
243 2593-2597 Species denotes mice Tax:10090
244 77-80 Species denotes HIV Tax:12721
245 328-331 Species denotes HIV Tax:12721
246 408-411 Species denotes HIV Tax:12721
247 1561-1564 Species denotes HIV Tax:12721
248 1672-1675 Species denotes HIV Tax:12721
249 2161-2164 Species denotes HIV Tax:12721
250 2358-2366 Chemical denotes morphine MESH:D009020
251 2460-2469 Chemical denotes maraviroc MESH:D000077592
252 2481-2489 Chemical denotes morphine MESH:D009020
253 2575-2583 Chemical denotes morphine MESH:D009020
254 63-71 Disease denotes infected MESH:D007239
255 441-445 Disease denotes pain MESH:D010146
256 467-490 Disease denotes peripheral neuropathies MESH:D010523
258 1455-1481 Disease denotes immune deficiency syndrome MESH:D007153
259 1483-1487 Disease denotes AIDS MESH:D000163
524 4987-4990 Gene denotes CD4 Gene:920
525 5097-5100 Gene denotes OST Gene:1650
526 5141-5144 Gene denotes p24 Gene:140767
527 5232-5236 Gene denotes CD68 Gene:968
528 5387-5390 Gene denotes OST Gene:1650
529 5483-5487 Gene denotes CD68 Gene:968
530 5589-5593 Gene denotes CD68 Gene:968
531 5648-5652 Gene denotes CD68 Gene:968
532 5778-5783 Gene denotes TNF-α Gene:7124
533 5867-5873 Gene denotes MIP-1α Gene:6348
534 5875-5881 Gene denotes MIP-1β Gene:6351
535 5883-5888 Gene denotes MCP-2 Gene:6355
536 5929-5933 Gene denotes CCR5 Gene:1234
537 6217-6220 Gene denotes OST Gene:1650
538 6783-6786 Gene denotes OST Gene:1650
539 7754-7757 Gene denotes OST Gene:1650
540 7795-7799 Gene denotes PENK Gene:5179
541 7842-7846 Gene denotes PENK Gene:5179
542 7991-7996 Gene denotes OPRM1 Gene:4988
543 8049-8052 Gene denotes MOR Gene:4988
544 8185-8190 Gene denotes OPRM1 Gene:4988
545 8330-8334 Gene denotes CCL2 Gene:6347
546 8342-8346 Gene denotes CCL5 Gene:6352
547 8356-8361 Gene denotes CXCR4 Gene:7852
548 8363-8367 Gene denotes CCR5 Gene:1234
549 8436-8440 Gene denotes OPRK Gene:4986
550 8445-8449 Gene denotes PDYN Gene:5173
551 8481-8485 Gene denotes OPRK Gene:4986
552 8490-8494 Gene denotes PDYN Gene:5173
553 9019-9022 Gene denotes CD4 Gene:713807
554 9278-9281 Gene denotes CD4 Gene:920
555 9532-9535 Gene denotes CD4 Gene:920
556 9711-9714 Gene denotes CD4 Gene:713807
557 9830-9833 Gene denotes CD4 Gene:713807
558 10285-10290 Gene denotes PSD95 Gene:1742
559 10576-10582 Gene denotes PDGF-B Gene:703173
560 10625-10631 Gene denotes PDGF-B Gene:703173
561 10782-10786 Gene denotes Tat1 Gene:72472
562 11051-11056 Gene denotes HSPA5 Gene:14828
563 11065-11070 Gene denotes HSPA5 Gene:14828
564 11614-11618 Gene denotes Tat1 Gene:72472
565 11668-11672 Gene denotes Iba1 Gene:114737
566 11697-11700 Gene denotes Tat Gene:234724
567 11740-11744 Gene denotes Tat1 Gene:72472
568 11819-11823 Gene denotes CCL2 Gene:20296
569 11854-11858 Gene denotes CCR5 Gene:12774
570 11863-11867 Gene denotes CCL2 Gene:20296
571 11895-11899 Gene denotes CCL2 Gene:20296
572 11927-11930 Gene denotes Tat Gene:234724
573 12092-12095 Gene denotes Tat Gene:234724
574 12122-12126 Gene denotes TNFα Gene:21926
575 12128-12132 Gene denotes IL-6 Gene:16193
576 12134-12138 Gene denotes CCL2 Gene:20296
577 12144-12148 Gene denotes TLR2 Gene:24088
578 12150-12154 Gene denotes TLR4 Gene:21898
579 12156-12160 Gene denotes TLR9 Gene:81897
580 12222-12225 Gene denotes MOR Gene:4988
581 12247-12252 Gene denotes gp120 Gene:3700
582 12317-12320 Gene denotes MOR Gene:4988
583 12353-12357 Gene denotes Tat1 Gene:116369
584 12461-12464 Gene denotes CPu Gene:56373
585 12535-12538 Gene denotes Tat Gene:234724
586 12653-12657 Gene denotes Tat1 Gene:72472
587 12838-12842 Gene denotes CCR5 Gene:12774
588 12859-12862 Gene denotes Tat Gene:234724
589 13016-13020 Gene denotes Brd4 Gene:362844
590 13038-13043 Gene denotes gp120 Gene:3700
591 13095-13099 Gene denotes Tat1 Gene:170566
592 13198-13201 Gene denotes Tat Gene:234724
593 13274-13278 Gene denotes Tat1 Gene:72472
594 13378-13381 Gene denotes Tat Gene:234724
595 13433-13437 Gene denotes Tat1 Gene:72472
596 13561-13564 Gene denotes Tat Gene:234724
597 13738-13742 Gene denotes Tat1 Gene:116369
598 13816-13819 Gene denotes Tat Gene:234724
599 13967-13970 Gene denotes Tat Gene:234724
600 14153-14158 Gene denotes CXCR4 Gene:7852
601 14163-14167 Gene denotes CCR5 Gene:1234
602 14441-14444 Gene denotes Tat Gene:234724
603 14497-14501 Gene denotes Tat1 Gene:72472
604 14583-14586 Gene denotes Tat Gene:234724
605 4637-4642 Species denotes human Tax:9606
606 4822-4827 Species denotes Human Tax:9606
607 4925-4930 Species denotes Human Tax:9606
608 4932-4938 Species denotes Lemons Tax:2708
609 4998-5003 Species denotes Human Tax:9606
610 5145-5150 Species denotes Human Tax:9606
611 5284-5289 Species denotes Human Tax:9606
612 5416-5421 Species denotes Human Tax:9606
613 5488-5493 Species denotes Human Tax:9606
614 5653-5658 Species denotes Human Tax:9606
615 5804-5809 Species denotes Human Tax:9606
616 5958-5963 Species denotes Human Tax:9606
617 6085-6090 Species denotes Human Tax:9606
618 6194-6203 Species denotes marijuana Tax:3483
619 6326-6331 Species denotes Human Tax:9606
620 6468-6473 Species denotes Human Tax:9606
621 6568-6573 Species denotes Human Tax:9606
622 6628-6637 Species denotes marijuana Tax:3483
623 6691-6696 Species denotes Human Tax:9606
624 6787-6792 Species denotes Human Tax:9606
625 6947-6952 Species denotes Human Tax:9606
626 7107-7112 Species denotes women Tax:9606
627 7176-7181 Species denotes Human Tax:9606
628 7359-7364 Species denotes Human Tax:9606
629 7446-7451 Species denotes Human Tax:9606
630 7539-7544 Species denotes Human Tax:9606
631 7665-7670 Species denotes Human Tax:9606
632 7766-7771 Species denotes Human Tax:9606
633 7945-7950 Species denotes Human Tax:9606
634 8111-8118 Species denotes tobacco Tax:4097
635 8140-8145 Species denotes Human Tax:9606
636 8246-8251 Species denotes Human Tax:9606
637 8392-8397 Species denotes Human Tax:9606
638 8550-8555 Species denotes Human Tax:9606
639 8681-8686 Species denotes Human Tax:9606
640 8930-8945 Species denotes Rhesus macaques Tax:9544
641 9100-9115 Species denotes Rhesus macaques Tax:9544
642 9317-9332 Species denotes Rhesus macaques Tax:9544
643 9632-9647 Species denotes Rhesus macaques Tax:9544
644 10209-10214 Species denotes HIV-1 Tax:11676
645 10352-10357 Species denotes Mouse Tax:10090
646 10465-10468 Species denotes Rat Tax:10116
647 10470-10475 Species denotes HIV-1 Tax:11676
648 10692-10707 Species denotes Rhesus macaques Tax:9544
649 10847-10852 Species denotes Mouse Tax:10090
650 11087-11102 Species denotes Rhesus macaques Tax:9544
651 11104-11109 Species denotes Human Tax:9606
652 11326-11341 Species denotes Rhesus macaques Tax:9544
653 11560-11575 Species denotes Rhesus macaques Tax:9544
654 11690-11695 Species denotes Mouse Tax:10090
655 11956-11961 Species denotes Mouse Tax:10090
656 12161-12166 Species denotes Mouse Tax:10090
657 12237-12242 Species denotes HIV-1 Tax:11676
658 12276-12280 Species denotes Rats Tax:10116
659 12282-12287 Species denotes HIV-1 Tax:11676
660 12523-12527 Species denotes mice Tax:10090
661 12528-12533 Species denotes Mouse Tax:10090
662 12852-12857 Species denotes Mouse Tax:10090
663 13026-13029 Species denotes Rat Tax:10116
664 13191-13196 Species denotes Mouse Tax:10090
665 13371-13376 Species denotes Mouse Tax:10090
666 13554-13559 Species denotes Mouse Tax:10090
667 13699-13714 Species denotes Rhesus macaques Tax:9544
668 13809-13814 Species denotes Mouse Tax:10090
669 13960-13965 Species denotes Mouse Tax:10090
670 14101-14114 Species denotes S. pneumoniae Tax:1313
671 14193-14198 Species denotes Mouse Tax:10090
672 14215-14228 Species denotes S. pneumoniae Tax:1313
673 14434-14439 Species denotes Mouse Tax:10090
674 14576-14581 Species denotes Mouse Tax:10090
675 4559-4562 Species denotes HIV Tax:12721
676 4644-4647 Species denotes HIV Tax:12721
677 5137-5140 Species denotes HIV Tax:12721
678 5275-5278 Species denotes HIV Tax:12721
679 5441-5444 Species denotes HIV Tax:12721
680 5534-5537 Species denotes HIV Tax:12721
681 5604-5607 Species denotes HIV Tax:12721
682 5993-5996 Species denotes HIV Tax:12721
683 6054-6057 Species denotes HIV Tax:12721
684 6159-6162 Species denotes HIV Tax:12721
685 6303-6306 Species denotes HIV Tax:12721
686 6502-6505 Species denotes HIV Tax:12721
687 6593-6596 Species denotes HIV Tax:12721
688 7061-7064 Species denotes HIV Tax:12721
689 7130-7133 Species denotes HIV Tax:12721
690 7336-7339 Species denotes HIV Tax:12721
691 7396-7399 Species denotes HIV Tax:12721
692 7481-7484 Species denotes HIV Tax:12721
693 7592-7595 Species denotes HIV Tax:12721
694 7711-7714 Species denotes HIV Tax:12721
695 7811-7814 Species denotes HIV Tax:12721
696 7859-7862 Species denotes HIV Tax:12721
697 7874-7877 Species denotes HIV Tax:12721
698 7890-7893 Species denotes HIV Tax:12721
699 8028-8031 Species denotes HIV Tax:12721
700 8168-8171 Species denotes HIV Tax:12721
701 8215-8218 Species denotes HIV Tax:12721
702 8277-8280 Species denotes HIV Tax:12721
703 8464-8467 Species denotes HIV Tax:12721
704 8519-8522 Species denotes HIV Tax:12721
705 8753-8756 Species denotes HIV Tax:12721
706 8811-8815 Species denotes SHIV Tax:57667
707 9154-9157 Species denotes HIV Tax:12721
708 9204-9208 Species denotes SHIV Tax:57667
709 9455-9459 Species denotes SHIV Tax:57667
710 10391-10394 Species denotes HIV Tax:12721
711 10447-10450 Species denotes HIV Tax:12721
712 12007-12010 Species denotes HIV Tax:12721
713 11511-11514 Gene denotes SIV Gene:8114
714 11028-11031 Gene denotes SIV Gene:8114
715 10617-10620 Gene denotes SIV Gene:8114
716 10059-10062 Gene denotes SIV Gene:8114
717 9887-9890 Gene denotes SIV Gene:8114
718 9761-9764 Gene denotes SIV Gene:8114
719 9584-9587 Gene denotes SIV Gene:8114
720 9390-9393 Gene denotes SIV Gene:8114
721 9313-9316 Gene denotes SIV Gene:8114
722 7720-7723 Gene denotes OST Gene:1650
723 7604-7607 Gene denotes OST Gene:1650
724 7490-7493 Gene denotes OST Gene:1650
725 7408-7411 Gene denotes OST Gene:1650
726 7252-7255 Gene denotes OST Gene:1650
727 6754-6757 Gene denotes OST Gene:1650
728 12904-12909 Gene denotes gp120 Gene:3700
729 10203-10208 Gene denotes gp120 Gene:3700
730 9726-9729 Gene denotes nef Gene:6285
732 14275-14278 Gene denotes Tat Gene:6898
733 14038-14041 Gene denotes Tat Gene:6898
734 13866-13869 Gene denotes Tat Gene:6898
735 12519-12522 Gene denotes Tat Gene:6898
736 12011-12014 Gene denotes Tat Gene:6898
737 11059-11062 Gene denotes Tat Gene:6898
738 10513-10516 Gene denotes Tat Gene:6898
739 9604-9607 Gene denotes tat Gene:6898
740 9545-9548 Gene denotes tat Gene:6898
741 11966-11970 Gene denotes Hage Gene:55510
742 5948-5951 Gene denotes CD4 Gene:920
743 9935-9938 Gene denotes CSF Gene:3918
744 9045-9048 Gene denotes CSF Gene:3918
745 8872-8875 Gene denotes CSF Gene:3918
746 12942-12950 Chemical denotes Morphine MESH:D009020
747 13068-13076 Chemical denotes Morphine MESH:D009020
748 13106-13114 Chemical denotes Morphine MESH:D009020
749 14341-14353 Chemical denotes Dolutegravir MESH:C562325
750 14358-14366 Chemical denotes abacavir MESH:C106538
751 14385-14395 Chemical denotes lamivudine MESH:D019259
752 14409-14417 Chemical denotes morphine MESH:D009020
753 14508-14516 Chemical denotes Morphine MESH:D009020
754 4667-4695 Disease denotes ARV adherence HIV cART • SUD MESH:D015658
755 4723-4727 Disease denotes pain MESH:D010146
756 4811-4815 Disease denotes pain MESH:D010146
757 4848-4860 Disease denotes HIV cART OUD MESH:D015658
758 4952-4959 Disease denotes HIV ARV MESH:D015658
759 5028-5077 Disease denotes HIV encephalitis (HIVE) HIV infection CNS HIV ZDV MESH:D015658
760 5210-5229 Disease denotes HIV • ARV • ZDV OUD MESH:D015658
761 5328-5343 Disease denotes HIV • ARV • ZDV MESH:D015658
762 5713-5725 Disease denotes HIV cART OUD MESH:D015658
763 5829-5836 Disease denotes HIV ARV MESH:D015658
764 5921-5924 Disease denotes LPS MESH:C536528
765 6253-6269 Disease denotes hypersensitivity MESH:D004342
766 6355-6374 Disease denotes Learning-memory HIV MESH:D007859
767 6434-6467 Disease denotes Learning slope • ↓ Delayed recall MESH:D008569
768 6535-6567 Disease denotes Recall memory • ↓ Working memory MESH:D008569
769 6817-6862 Disease denotes Cognitive function HIV cART OUD • ↓ Cognitive MESH:D003072
770 6973-7011 Disease denotes Memory Cognitive function HIV cART SUD MESH:D015658
771 7203-7236 Disease denotes Visual and cognitive function HIV MESH:D003072
772 8581-8635 Disease denotes Sensory Neuropathy HIV cART SUD HIV sensory neuropathy MESH:D000699
773 10075-10084 Disease denotes mortality MESH:D003643
774 10159-10174 Disease denotes Neuronal injury MESH:D009410
775 10310-10338 Disease denotes withdrawal • ↑ Sphingomyelin MESH:D013375
776 11119-11132 Disease denotes neuroblastoma MESH:D009447
777 11149-11157 Disease denotes Pendyala
778 11264-11285 Disease denotes demyelinating lesions MESH:D003711
779 12083-12088 Disease denotes death MESH:D003643
780 12108-12117 Disease denotes infection MESH:D007239
781 12893-12903 Disease denotes Neuropathy MESH:D009422
782 12993-13011 Disease denotes Mechanic allodynia MESH:D006930
783 14115-14123 Disease denotes infected MESH:D007239
784 14204-14213 Disease denotes infection MESH:D007239
785 11111-11118 CellLine denotes SH-SY5Y CVCL:0019
786 8044-8048 Mutation denotes C17T rs1799972
787 10020-10024 Mutation denotes R50G p.R50G
789 14627-14634 Gene denotes Clade B
804 14818-14822 Gene denotes Brd4 Gene:23476
805 14824-14856 Gene denotes Bromodomain-containing protein 4 Gene:23476
806 14858-14861 Gene denotes CPu Gene:1361
807 15141-15146 Gene denotes HSPA5 Gene:3309
808 15250-15254 Gene denotes Iba1 Gene:199
809 15256-15298 Gene denotes ionized calcium-binding adapter molecule 1 Gene:199
810 15417-15420 Gene denotes MOR Gene:4988
811 15422-15439 Gene denotes μ-opioid receptor Gene:4988
812 15489-15492 Gene denotes OST Gene:1650
813 15573-15577 Gene denotes PENK Gene:5179
814 15579-15595 Gene denotes preproenkephalin Gene:5179
815 14968-14971 Gene denotes CSF Gene:3918
816 15724-15734 Species denotes transgenic Tax:10090
817 15097-15113 Disease denotes HIV encephalitis MESH:D004660
821 16010-16013 Species denotes HIV Tax:12721
822 16177-16180 Species denotes HIV Tax:12721
823 16292-16295 Species denotes HIV Tax:12721
843 2935-2938 Gene denotes CD4 Gene:920
844 4020-4023 Gene denotes CD4 Gene:920
845 2960-2963 Species denotes HIV Tax:12721
846 4408-4411 Species denotes HIV Tax:12721
847 2893-2899 Chemical denotes heroin MESH:D003932
848 3016-3022 Chemical denotes heroin MESH:D003932
849 2668-2672 Disease denotes AIDS MESH:D000163
850 2782-2794 Disease denotes opiate abuse MESH:D009293
851 2819-2835 Disease denotes HIV encephalitis MESH:D004660
852 3169-3174 Disease denotes death MESH:D003643
853 3180-3184 Disease denotes AIDS MESH:D000163
854 3207-3231 Disease denotes opportunistic infections MESH:D009894
855 3284-3307 Disease denotes HIV-associated dementia MESH:D015526
856 3309-3312 Disease denotes HAD MESH:C535310
857 3339-3378 Disease denotes HIV-associated neurocognitive disorders MESH:D020943
858 3661-3681 Disease denotes cognitive impairment MESH:D003072
859 4103-4112 Disease denotes tauopathy MESH:D024801
860 4138-4150 Disease denotes inflammation MESH:D007249
861 4289-4326 Disease denotes deficits in memory and working memory MESH:D008569
867 16780-16789 Species denotes Churchill Tax:868862
868 16635-16638 Species denotes HIV Tax:12721
869 16775-16778 Species denotes HIV Tax:12721
870 17089-17092 Species denotes HIV Tax:12721
871 16703-16712 Disease denotes infection MESH:D007239

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T71218 392-404 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T29450 642-650 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior
T85138 1430-1442 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T40073 1774-1779 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T73616 1841-1850 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T73908 2033-2038 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T70017 4138-4150 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18180 4301-4307 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T79044 4320-4326 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T60696 6142-6158 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T35984 6253-6269 http://purl.obolibrary.org/obo/GO_0002524 denotes hypersensitivity
T69969 6355-6370 http://purl.obolibrary.org/obo/GO_0007611 denotes Learning-memory
T74458 6355-6363 http://purl.obolibrary.org/obo/GO_0007612 denotes Learning
T70873 6364-6370 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T14119 6422-6430 http://purl.obolibrary.org/obo/GO_0007612 denotes learning
T38670 6434-6442 http://purl.obolibrary.org/obo/GO_0007612 denotes Learning
T338 6542-6548 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T64140 6561-6567 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T84433 6973-6979 http://purl.obolibrary.org/obo/GO_0007613 denotes Memory
T61490 7051-7057 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T75389 8356-8361 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T57833 10431-10446 http://purl.obolibrary.org/obo/GO_0043524 denotes neuron survival
T93715 10635-10650 http://purl.obolibrary.org/obo/GO_0043524 denotes neuron survival
T1026 10760-10781 http://purl.obolibrary.org/obo/GO_0007268 denotes Synaptic transmission
T99406 14005-14028 http://purl.obolibrary.org/obo/GO_0050900 denotes Immune cell trafficking
T43 14153-14158 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T44 14479-14496 http://purl.obolibrary.org/obo/GO_0007623 denotes Circadian rhythms
T45 14914-14942 http://purl.obolibrary.org/obo/GO_1990708 denotes conditioned place preference
T46 16389-16402 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T47 16455-16468 http://purl.obolibrary.org/obo/GO_0006412 denotes translational

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T137 0-55 Sentence denotes Preclinical and Clinical Findings—a Complicated Picture
T138 56-170 Sentence denotes People infected with HIV (PWH) with OUD have an increased incidence of neuroHIV and CNS complications (Bell et al.
T139 171-188 Sentence denotes 1998; Nath et al.
T140 189-222 Sentence denotes 1999, 2000a, 2002; Anthony et al.
T141 223-241 Sentence denotes 2008; Meyer et al.
T142 242-260 Sentence denotes 2013; Smith et al.
T143 261-267 Sentence denotes 2014).
T144 268-344 Sentence denotes Injection drug use increases the probability of contracting HIV (Nath et al.
T145 345-412 Sentence denotes 1999) and opioid drugs intrinsically alter the pathogenesis of HIV.
T146 413-550 Sentence denotes PWH who develop intractable pain syndromes related to peripheral neuropathies often receive opioid drugs for treatment (Mirsattari et al.
T147 551-569 Sentence denotes 1999; Denis et al.
T148 570-576 Sentence denotes 2019).
T149 577-752 Sentence denotes PWH who misuse opioids are more likely to undertake risky sexual behavior and are less likely to adhere to combined antiretroviral (ARV) therapy (cART) regimens (Lemons et al.
T150 753-759 Sentence denotes 2019).
T151 760-923 Sentence denotes Opioid receptors are widely expressed on immune cells and opioids can modulate immune function (Donahoe and Falek 1988; Plotnikoff 1988; Rouveix 1992; Adler et al.
T152 924-962 Sentence denotes 1993; Carr and Serou 1995; Carr et al.
T153 963-981 Sentence denotes 1996; Sheng et al.
T154 982-1003 Sentence denotes 1997; Banerjee et al.
T155 1004-1024 Sentence denotes 2011; Purohit et al.
T156 1025-1108 Sentence denotes 2012), which typically (but not always) result in immune suppression (Wybran et al.
T157 1109-1131 Sentence denotes 1979; McDonough et al.
T158 1132-1182 Sentence denotes 1980, 1981; Donahoe and Falek 1988; Donahoe et al.
T159 1183-1201 Sentence denotes 1991; Falek et al.
T160 1202-1221 Sentence denotes 1991; Novick et al.
T161 1222-1239 Sentence denotes 1991; Chao et al.
T162 1240-1262 Sentence denotes 1996a; Peterson et al.
T163 1263-1307 Sentence denotes 1998; Rogers and Peterson 2003; Stein et al.
T164 1308-1324 Sentence denotes 2003; Roy et al.
T165 1325-1345 Sentence denotes 2006; Rittner et al.
T166 1346-1352 Sentence denotes 2008).
T167 1353-1609 Sentence denotes The “opiate cofactor hypothesis” proposes opioids contribute directly to the pathogenesis of acquired immune deficiency syndrome (AIDS) (Donahoe and Vlahov 1998), in part, because MOR activation can increase HIV replication in immune cells (Peterson et al.
T168 1610-1643 Sentence denotes 1990, 1992, 1993, 1999; Ho et al.
T169 1644-1650 Sentence denotes 2003).
T170 1651-1725 Sentence denotes Furthermore, MOR and HIV co-receptors, including both CCR5 (El-Hage et al.
T171 1726-1743 Sentence denotes 2013; Yuan et al.
T172 1744-1763 Sentence denotes 2013; Arnatt et al.
T173 1764-1795 Sentence denotes 2016) and CXCR4 (Pitcher et al.
T174 1796-1911 Sentence denotes 2014) can interact via convergent downstream signaling and perhaps via direct molecular interactions (Rogers et al.
T175 1912-1957 Sentence denotes 2000; Rogers and Peterson 2003; Steele et al.
T176 1958-1975 Sentence denotes 2003; Chen et al.
T177 1976-1993 Sentence denotes 2004; Song et al.
T178 1994-2013 Sentence denotes 2011; Arnatt et al.
T179 2014-2020 Sentence denotes 2016).
T180 2021-2101 Sentence denotes MOR-CCR5 or CXCR4 interactions are highly contextual and can promote (Guo et al.
T181 2102-2121 Sentence denotes 2002; Steele et al.
T182 2122-2154 Sentence denotes 2003) or inhibit (Strazza et al.
T183 2155-2252 Sentence denotes 2014) HIV expression, depending on the nature and duration of exposure (see Fig. 9; Berman et al.
T184 2253-2293 Sentence denotes 2006) and cell type involved (Kim et al.
T185 2294-2300 Sentence denotes 2018).
T186 2301-2405 Sentence denotes Depending on the outcome measure, Tat expression reduces morphine’s efficacy and potency (Fitting et al.
T187 2406-2429 Sentence denotes 2012, 2016; Hahn et al.
T188 2430-2436 Sentence denotes 2016).
T189 2437-2611 Sentence denotes Antagonizing CCR5 with maraviroc reinstates morphine potency in an antinociceptive assay and restores physical dependence in Tat exposed, morphine-tolerant mice (Gonek et al.
T190 2612-2618 Sentence denotes 2018).
T191 2619-2724 Sentence denotes Epidemiological studies suggest OUD can increase AIDS progression (Donahoe and Vlahov 1998; Dronda et al.
T192 2725-2747 Sentence denotes 2004; Meijerink et al.
T193 2748-2760 Sentence denotes 2014, 2015).
T194 2761-2855 Sentence denotes In the pre-cART era, opiate abuse was found to exacerbate HIV encephalitis (HIVE) (Bell et al.
T195 2856-2868 Sentence denotes 1998, 2002).
T196 2869-3040 Sentence denotes In Indonesian injection heroin abusers who lacked access to cART, CD4 counts (a measure of HIV progression) were reduced compared to PWH not using heroin (Meijerink et al.
T197 3041-3047 Sentence denotes 2014).
T198 3048-3401 Sentence denotes However, with the introduction of cART, the clinical picture has significantly changed with a 50% decline in the rate of death from AIDS, reduced incidence of opportunistic infections and HIVE, and a 40–50% decrease in the incidence of HIV-associated dementia (HAD), the most severe form of HIV-associated neurocognitive disorders (HAND) (Maschke et al.
T199 3402-3423 Sentence denotes 2000; McArthur et al.
T200 3424-3443 Sentence denotes 2010; Saylor et al.
T201 3444-3450 Sentence denotes 2016).
T202 3451-3611 Sentence denotes Nevertheless, chronic opiate exposure (which almost always is confounded by the use of other illicit and legal drugs) in PWH can worsen neuroHIV (Anthony et al.
T203 3612-3629 Sentence denotes 2005; Bell et al.
T204 3630-3650 Sentence denotes 2006; Anthony et al.
T205 3651-3707 Sentence denotes 2008) and cognitive impairment (Rodriguez Salgado et al.
T206 3708-3757 Sentence denotes 2006; Martin-Thormeyer and Paul 2009; Byrd et al.
T207 3758-3776 Sentence denotes 2011; Smith et al.
T208 3777-3796 Sentence denotes 2014; Martin et al.
T209 3797-3815 Sentence denotes 2018; Rubin et al.
T210 3816-3916 Sentence denotes 2018) despite cART, even though some studies fail to show that opioids worsen neuroHIV (Royal et al.
T211 3917-3939 Sentence denotes 1991; Applebaum et al.
T212 3940-3968 Sentence denotes 2010) or HAND (Martin et al.
T213 3969-3975 Sentence denotes 2019).
T214 3976-4059 Sentence denotes Opiate exposure in cART-treated PWH worsens CD4 counts and viral loads (Ryan et al.
T215 4060-4126 Sentence denotes 2004), neuropathology (including increased tauopathy; Smith et al.
T216 4127-4166 Sentence denotes 2014), CNS inflammation (Anthony et al.
T217 4167-4191 Sentence denotes 2005, 2008; Smith et al.
T218 4192-4235 Sentence denotes 2014), and neurocognition (Applebaum et al.
T219 4236-4253 Sentence denotes 2009; Byrd et al.
T220 4254-4272 Sentence denotes 2011; Meyer et al.
T221 4273-4339 Sentence denotes 2013) including deficits in memory and working memory (Byrd et al.
T222 4340-4346 Sentence denotes 2011).
T223 4347-4502 Sentence denotes Table 1 gives an overview on reported interactive effects of HIV and opioids in some of the clinical and preclinical CNS studies referenced in this review.
T224 4503-4544 Sentence denotes Table 1 Clinical and preclinical findings
T225 4545-4617 Sentence denotes Major effects HIV pathogena ARV Opioids Outcome Model system Citation(s)
T226 4618-4643 Sentence denotes Clinical findings (human)
T227 4644-4695 Sentence denotes HIV progression and/or ARV adherence HIV cART • SUD
T228 4696-4751 Sentence denotes • Prescription opioids for pain • ↑ Viral load with SUD
T229 4752-4769 Sentence denotes • ↓ ARV adherence
T230 4770-4841 Sentence denotes • ↑ Frequency of prescription drugs with pain + SUD Human (Denis et al.
T231 4842-4847 Sentence denotes 2019)
T232 4848-4890 Sentence denotes HIV cART OUD • ↓ Lasting viral suppression
T233 4891-4945 Sentence denotes • ↓ Adherence to cART for 3 years Human (Lemons et al.
T234 4946-4951 Sentence denotes 2019)
T235 4952-5021 Sentence denotes HIV ARV naive Injection drug use ↓ CD4 counts Human (Meijerink et al.
T236 5022-5027 Sentence denotes 2014)
T237 5028-5051 Sentence denotes HIV encephalitis (HIVE)
T238 5052-5132 Sentence denotes HIV infection CNS HIV ZDV Former drug use (+ OST) • ↑ Multinucleated giant cells
T239 5133-5181 Sentence denotes • ↑ HIV p24 Human, postmortem brain (Bell et al.
T240 5182-5187 Sentence denotes 1998)
T241 5188-5219 Sentence denotes Microglial activation HIV • ARV
T242 5220-5321 Sentence denotes • ZDV OUD ↑ CD68 microglial activation only in non-OUD HIV+ PWH Human, postmortem brain (Smith et al.
T243 5322-5327 Sentence denotes 2014)
T244 5328-5337 Sentence denotes HIV • ARV
T245 5338-5434 Sentence denotes • ZDV, other monotherapies Injection drug use (+ OST) ↑ Microglial activation Human (Bell et al.
T246 5435-5440 Sentence denotes 2002)
T247 5441-5478 Sentence denotes HIV No info Drug use • ↑ MHC class II
T248 5479-5527 Sentence denotes • ↑ CD68 Human, postmortem brain (Anthony et al.
T249 5528-5533 Sentence denotes 2005)
T250 5534-5625 Sentence denotes HIV No info OUD (44% methadone, 36% other opiates) • ↓ CD68, HLA-D in HIV and HIVE with OUD
T251 5626-5689 Sentence denotes • No effect of IDU on CD68 Human, postmortem brain (Byrd et al.
T252 5690-5695 Sentence denotes 2012)
T253 5696-5822 Sentence denotes Plasma cytokines HIV cART OUD (codeine, fentanyl, morphine) ↑ sTNF-R2, not sCD14, TNF-α, sTNF-R1, in plasma Human (Ryan et al.
T254 5823-5828 Sentence denotes 2004)
T255 5829-5924 Sentence denotes HIV ARV naive Reported heroin use • ↓ MIP-1α, MIP-1β, MCP-2 in blood after stimulation with LPS
T256 5925-5981 Sentence denotes • ↑ CCR5 expression in CD4 cells Human (Meijerink et al.
T257 5982-5987 Sentence denotes 2015)
T258 5988-6049 Sentence denotes HIVE HIV No info OUD • ↑ Parenchymal inflammatory infiltrates
T259 6050-6126 Sentence denotes • ↑ HIV PCR amplification products Human, postmortem brain (Gosztonyi et al.
T260 6127-6132 Sentence denotes 1993)
T261 6133-6297 Sentence denotes Aberrant immune responses HIV No info SUD (opioids, alcohol, marijuana, cocaine) (+ OST) • ↑ Autoantibodies and delayed hypersensitivity to neural antigens OUD only
T262 6298-6348 Sentence denotes • No HIV effect/interaction Human (Jankovic et al.
T263 6349-6354 Sentence denotes 1991)
T264 6355-6448 Sentence denotes Learning-memory HIV 50-70% on cART Heroin, crack/cocaine • ↓ Total learning; ↓ Learning slope
T265 6449-6495 Sentence denotes • ↓ Delayed recall Human, female (Meyer et al.
T266 6496-6501 Sentence denotes 2013)
T267 6502-6548 Sentence denotes HIV cART Reported heroin use • ↓ Recall memory
T268 6549-6586 Sentence denotes • ↓ Working memory Human (Byrd et al.
T269 6587-6592 Sentence denotes 2011)
T270 6593-6671 Sentence denotes HIV No info SUD (opioids, alcohol, marijuana, cocaine) • ↓ Complex figure copy
T271 6672-6711 Sentence denotes • ↓ Delayed recall Human (Concha et al.
T272 6712-6717 Sentence denotes 1997)
T273 6718-6810 Sentence denotes Neuropsychological performance cART OST (methadone) No effect of OST Human (Applebaum et al.
T274 6811-6816 Sentence denotes 2010)
T275 6817-6966 Sentence denotes Cognitive function HIV cART OUD • ↓ Cognitive performance with anticholinergics, but not opioids, anxiolytics, or anticonvulsants Human (Rubin et al.
T276 6967-6972 Sentence denotes 2018)
T277 6973-6979 Sentence denotes Memory
T278 6980-7065 Sentence denotes Cognitive function HIV cART SUD (alcohol, cocaine, heroin) • ↓ Working memory in HIV+
T279 7066-7140 Sentence denotes • ↓ Spatial and verbal response times in women, irrespective of HIV status
T280 7141-7196 Sentence denotes • ↑ Response time with cocaine use Human (Martin et al.
T281 7197-7202 Sentence denotes 2018)
T282 7203-7330 Sentence denotes Visual and cognitive function HIV No info OUD (+ OST, methadone) • ↑ Pattern-shift visual evoked potential delay with methadone
T283 7331-7377 Sentence denotes • No HIV effect/interaction Human (Bauer 1998)
T284 7378-7480 Sentence denotes Transmission risk HIV No info OST ↓ Frequency of injection drug use Human (Kwiatkowski and Booth 2001)
T285 7481-7527 Sentence denotes HIV cART OST • ↓ Frequency of heroin injection
T286 7528-7559 Sentence denotes • ↑ On ARV Human (Pettes et al.
T287 7560-7565 Sentence denotes 2010)
T288 7566-7639 Sentence denotes Motor and visual function HIV No info OST • ↓ Digital Finger-Tapping test
T289 7640-7690 Sentence denotes • ↓ Visual motor pursuit Human (Silberstein et al.
T290 7691-7696 Sentence denotes 1993)
T291 7697-7788 Sentence denotes ARV adherence HIV cART OST • ↑ ARV adherence in PWH with OST vs. OUD Human (Mazhnaya et al.
T292 7789-7794 Sentence denotes 2018)
T293 7795-7863 Sentence denotes PENK expression HIV Pre- and post-cART SUD • ↓ PENK in HIVE vs. HIV−
T294 7864-7894 Sentence denotes • ↓ DRD2L HIV+ vs. HIVE & HIV−
T295 7895-7920 Sentence denotes • ↓ DRD2L correlates with
T296 7921-7984 Sentence denotes ↑ cognitive performance Human, post mortem brain (Gelman et al.
T297 7985-7990 Sentence denotes 2012)
T298 7991-8161 Sentence denotes OPRM1 polymorphisms, splice variants HIV No info SUD C17T MOR polymorphism correlates with ↑ risk of cocaine, alcohol & tobacco (but not opiate) use Human (Crystal et al.
T299 8162-8167 Sentence denotes 2012)
T300 8168-8270 Sentence denotes HIV cART No Some OPRM1 polymorphisms may alter HIV severity / response to ARV Human (Proudnikov et al.
T301 8271-8276 Sentence denotes 2012)
T302 8277-8325 Sentence denotes HIV No info MOR-1K expression • ↑ MOR-1K in HIVE
T303 8326-8429 Sentence denotes • ↑ CCL2, CCL6, CCL5, but not CXCR4, CCR5 or CD4 receptor in HIVE Human, postmortem brain (Dever et al.
T304 8430-8435 Sentence denotes 2014)
T305 8436-8574 Sentence denotes OPRK and PDYN polymorphisms HIV cART No Some OPRK and PDYN polymorphisms may alter HIV severity / response to ARV Human (Proudnikov et al.
T306 8575-8580 Sentence denotes 2013)
T307 8581-8708 Sentence denotes Sensory Neuropathy HIV cART SUD HIV sensory neuropathy- regardless of SUD (trends, not significant) Human (Robinson-Papp et al.
T308 8709-8714 Sentence denotes 2010)
T309 8715-8752 Sentence denotes Preclinical in vivo findings (animal)
T310 8753-8886 Sentence denotes HIV entry into the brain Mixture of SIV17-EFr, SHIVKU_1B, SHIV89.6P No Morphine (5 mg/kg i.m., b.i.d., ≤ 56 weeks) • ↑ CSF viral load
T311 8887-8959 Sentence denotes • ↑ Viral migration through BBB for SHIVKU Rhesus macaques (Kumar et al.
T312 8960-8965 Sentence denotes 2006)
T313 8966-9040 Sentence denotes SIVmacR71/17E No Morphine (3 mg/kg i.m., q.i.d.) • ↑ CD4+ and CD8+ T cells
T314 9041-9059 Sentence denotes • ↑ CSF viral load
T315 9060-9131 Sentence denotes • ↑ Infiltration of MDMs into the brain Rhesus macaques (Bokhari et al.
T316 9132-9138 Sentence denotes 2011).
T317 9139-9288 Sentence denotes Viral load and HIV progression Mixture of SIV17-EFr, SHIVKU _1B, SHIV89.6P No Morphine (5 mg/kg, i.m., t.i.d., 20 weeks) • ↑ Viral load; ↓ CD4 counts
T318 9289-9355 Sentence denotes • ↑ ROS with morphine + SIV Rhesus macaques (Perez-Casanova et al.
T319 9356-9383 Sentence denotes 2007; Perez-Casanova et al.
T320 9384-9389 Sentence denotes 2008)
T321 9390-9476 Sentence denotes SIV gene mutation/evolutiontat Mixture of SIV17-EFr, SHIVKU _1B, SHIV89.6P No Morphine
T322 9477-9542 Sentence denotes (5 mg/kg, i.m., t.i.d., 20–56 weeks) • ↑ Viral load; ↓ CD4 counts
T323 9543-9599 Sentence denotes • tat evolution—inverse correlation with SIV progression
T324 9600-9681 Sentence denotes • ↓ tat diversity with morphine Rhesus macaques (Noel and Kumar 2006; Noel et al.
T325 9682-9688 Sentence denotes 2006b)
T326 9689-9721 Sentence denotes nef • ↑ Viral load; ↓ CD4 counts
T327 9722-9800 Sentence denotes • ↓ nef evolution; no correlation with SIV progression ± morphine (Noel et al.
T328 9801-9807 Sentence denotes 2006a)
T329 9808-9840 Sentence denotes env • ↑ Viral load; ↓ CD4 counts
T330 9841-9913 Sentence denotes • ↑ env evolution (V4 region) correlates with SIV progression + morphine
T331 9914-9973 Sentence denotes • ↑ env evolution in CSF with morphine (Rivera-Amill et al.
T332 9974-9986 Sentence denotes 2007, 2010b)
T333 9987-10084 Sentence denotes vpr • ↓ vpr evolution and/or Vpr R50G mutation—inverse correlation with SIV progression/mortality
T334 10085-10152 Sentence denotes • ↓ vpr evolution with morphine (Noel and Kumar 2007; Rivera et al.
T335 10153-10158 Sentence denotes 2013)
T336 10159-10280 Sentence denotes Neuronal injury, survival, oxidative stress gp120 HIV-1LAV No Morphine (25 mg pellet, 5–7 days) • ↑ ROS during withdrawal
T337 10281-10320 Sentence denotes • ↓ PSD95 during chronic and withdrawal
T338 10321-10338 Sentence denotes • ↑ Sphingomyelin
T339 10339-10384 Sentence denotes • ↓ Ceramide Mouse, gp120 tgb (Bandaru et al.
T340 10385-10390 Sentence denotes 2011)
T341 10391-10498 Sentence denotes HIV No Morphine (37.5 mg s.c, 5 days) ↓ neuron survival HIV tg + morphine Rat, HIV-1 tg, female (Guo et al.
T342 10499-10504 Sentence denotes 2012)
T343 10505-10508 Sentence denotes SIV
T344 10509-10620 Sentence denotes HIV Tat No Morphine (3 mg/kg i.m., q.i.d., 3 weeks) • ↑ miR-29b, ↓ PDGF-B mRNA, ↑ PDGF-BB with morphine and SIV
T345 10621-10753 Sentence denotes • ↓ PDGF-B, ↓ neuron survival with CM from morphine-treated astrocytes Rhesus macaques; Ratb, primary neurons, astrocytes (Hu et al.
T346 10754-10759 Sentence denotes 2012)
T347 10760-10912 Sentence denotes Synaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)
T348 10913-10926 Sentence denotes SIVmacR71/17E
T349 10927-11005 Sentence denotes Tat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)
T350 11006-11056 Sentence denotes • Morphine in vitro • SIV ↑ Synaptic protein HSPA5
T351 11057-11103 Sentence denotes • Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;
T352 11104-11110 Sentence denotes Human,
T353 11111-11164 Sentence denotes SH-SY5Y neuroblastoma cells in vitro (Pendyala et al.
T354 11165-11170 Sentence denotes 2015)
T355 11171-11285 Sentence denotes White matter effects SIVmacR71/17E No Morphine (3 mg/kg i.m., q.i.d., ≤ 59 weeks) • ↑ Focal, demyelinating lesions
T356 11286-11358 Sentence denotes • ↑ Macrophages in areas of myelin loss Rhesus macaques (Marcario et al.
T357 11359-11365 Sentence denotes 2008),
T358 11366-11480 Sentence denotes CNS metabolites SIVsmm9 No info Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., ≤ 4 years) • ↑ Survival time
T359 11481-11531 Sentence denotes • ↑ Creatine in white matter (SIV + morphine only)
T360 11532-11589 Sentence denotes • ↑ Myo-inositol in putamen Rhesus macaques (Cloak et al.
T361 11590-11595 Sentence denotes 2011)
T362 11596-11722 Sentence denotes Neuroinflammation Tat1–86 No Morphine (10 mg/kg i.p., b.i.d., 5 days) ↑ Iba1+ 3-NT+ microglia Mouse, Tat tg, males (Zou et al.
T363 11723-11728 Sentence denotes 2011)
T364 11729-11747 Sentence denotes Chemokines Tat1–72
T365 11748-11858 Sentence denotes (25 μg intrastriatal injection) No Morphine (25 mg pellet, 5 days) • ↑ CCL2 in astrocytes is regulated by CCR5
T366 11859-11892 Sentence denotes • ↑ CCL2 in macrophages/microglia
T367 11893-11977 Sentence denotes • CCL2-knockout blocks morphine + Tat-induced glial reactivity Mouse (El-Hage et al.
T368 11978-11984 Sentence denotes 2008a)
T369 11985-12117 Sentence denotes Cytokines, Chemokines HIV Tat (10 μg/kg i.v.) No Morphine (25, 75 mg pellet, 6 days) • Morphine ↑ death in Tat + bacterial infection
T370 12118-12139 Sentence denotes • ↑ TNFα, IL-6, CCL2,
T371 12140-12215 Sentence denotes • ↑ TLR2, TLR4, TLR9 Mouse, male, in vivo; microglia in vitro (Dutta et al.
T372 12216-12221 Sentence denotes 2012)
T373 12222-12310 Sentence denotes MOR expression HIV-1IIIB gp120 (X4) No MOR ↑ MOR mRNA Rats, HIV-1 tg males (Chang et al.
T374 12311-12316 Sentence denotes 2007)
T375 12317-12397 Sentence denotes MOR-coupling efficacy to G proteins Tat1–86 No • Morphine (acute, 10 mg/kg i.p.)
T376 12398-12561 Sentence denotes • Morphine, DAMGO (ex vivo) ↓ [35S]GTPγS binding in NAc Shell, CPu, amygdala, PFC, but not hippocampus, with morphine in Tat mice Mouse, Tat tg, males (Hahn et al.
T377 12562-12567 Sentence denotes 2016)
T378 12568-12764 Sentence denotes Neuroinflammation; morphine tolerance (antinociception), physical withdrawal, reward Tat1–86 No Morphine (75 mg pellet, 5 days) • ↑ Tolerance (↓ anti-nociceptive potency and ↓ withdrawal symptoms)
T379 12765-12810 Sentence denotes • ↑ CPP and cytokines (24 h after withdrawal)
T380 12811-12886 Sentence denotes • Above effects reduced by CCR5 blockade Mouse, Tat tg, males (Gonek et al.
T381 12887-12892 Sentence denotes 2018)
T382 12893-13011 Sentence denotes Neuropathy gp120 (0.2 μg), q.d. intrathecally No Morphine (3 μg, intrathecally, b.i.d., 5 days) • ↑ Mechanic allodynia
T383 13012-13061 Sentence denotes • ↑ Brd4 mRNA Rat, males, gp120 (Takahashi et al.
T384 13062-13067 Sentence denotes 2018)
T385 13068-13227 Sentence denotes Morphine efficacy, potency Tat1–86 No Morphine (acute, 2–8 mg/kg s.c.) ↓ Antinociceptive potency and efficacy (tail flick) Mouse, Tat tg, males (Fitting et al.
T386 13228-13233 Sentence denotes 2012)
T387 13234-13346 Sentence denotes Morphine tolerance, physical dependence Tat1–86 No Morphine (75 mg pellet, 4 days) • ↑ Antinociceptive tolerance
T388 13347-13407 Sentence denotes • ↓ Physical dependence Mouse, Tat tg, males (Fitting et al.
T389 13408-13413 Sentence denotes 2016)
T390 13414-13595 Sentence denotes Locomotor function Tat1–86 No Oxycodone (0–10 mg/kg, i.p., 15 min prior behavioral assay) ↑ Locomotor activity, center entries (open field) Mouse, Tat tg, females (Salahuddin et al.
T391 13596-13601 Sentence denotes 2020)
T392 13602-13731 Sentence denotes SIVmacR71/17E No Morphine (escalating doses of 1–2.5 mg/kg i.m., q.i.d., 59 weeks) ↓ Motor skill Rhesus macaques (Marcario et al.
T393 13732-13737 Sentence denotes 2016)
T394 13738-13845 Sentence denotes Tat1–86 No Oxycodone (acute, 0.1–10 mg/kg, i.p.) ↑ Psychomotor effects Mouse, Tat tg, females (Paris et al.
T395 13846-13851 Sentence denotes 2020)
T396 13852-13998 Sentence denotes BBB integrity Tat No Morphine (25 mg pellet, 5 days) ↑ Dextran extravasation across the blood-brain barrier Mouse, Tat tg females (Leibrand et al.
T397 13999-14004 Sentence denotes 2019)
T398 14005-14141 Sentence denotes Immune cell trafficking into CNS Tat No Morphine • ↑ Infiltration of monocytes and T cells into S. pneumoniae-infected CNS with morphine
T399 14142-14257 Sentence denotes • ↑ T cell CXCR4 and CCR5 expression with morphine Mouse, CNS infection (S. pneumoniae), males (Dutta and Roy 2015)
T400 14258-14282 Sentence denotes ARV accumulation Tat DTG
T401 14283-14286 Sentence denotes ABC
T402 14287-14472 Sentence denotes 3TC Morphine (2 mg/day, s.c.. osmotic pump, 5 days) ↓ Dolutegravir and abacavir, but no change in lamivudine in brains of morphine-treated animals Mouse, Tat tg females (Leibrand et al.
T403 14473-14478 Sentence denotes 2019)
T404 14479-14611 Sentence denotes Circadian rhythms Tat1–86 No Morphine (25 mg pellet, last 5 days) ↓ Total wheel-running activity Mouse, Tat tg, males (Duncan et al.
T405 14612-14617 Sentence denotes 2008)
T406 14618-14731 Sentence denotes aassumed Clade B, unless noted otherwise; b sex not reported; c authors reported a trend that was not significant
T407 14732-15778 Sentence denotes ABC, abacavir; ARV, antiretroviral(s); BBB, blood-brain barrier; b.i.d., twice a day; Brd4, Bromodomain-containing protein 4; CPu, caudate-putamen; CNS, central nervous system; CPP, conditioned place preference; CM, conditioned medium; CSF, cerebrospinal fluid; DAMGO [D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DRD2L, type 2 dopamine receptor; DTG, dolutegravir; HIVE, HIV encephalitis (typically seen pre-cART); HSPA5, heat shock 70-kDa protein A 5; IDU, injection drug use; i.m., intramuscularly; i.p., intraperitoneal; Iba1, ionized calcium-binding adapter molecule 1; 3TC, lamivudine; MHC class II, major histocompatibility class II; mIPSC, miniature inhibitory postsynaptic currents; MOR, μ-opioid receptor; No info, information not provided or uncertain; OST, opioid substitution therapy; OUD, opioid use disorder; PFC, prefrontal cortex; PENK, preproenkephalin; q.d., once a day; q.i.d., four times a day; ROS, reactive oxygen species; s.c., subcutaneous; SUD, substance use disorder; tg, transgenic; t.i.d., three times a day; ZDV, zidovudine
T408 15779-15934 Sentence denotes For practicality, Tables 1 and 2 are limited to key studies in the CNS with emphasis on neuropathological or neuroimmune rather than psychosocial outcomes.
T409 15935-16379 Sentence denotes With deference toward the excellent studies we excluded: (1) on opioid and HIV effects on peripheral blood mononuclear cells (PBMCs), or on isolated lymphocytes and monocytes, not directly related to the central nervous system or BBB; (2) on HIV or opioid and ARV interactions in the peripheral nervous system; and (3) studies not directly examining opioid-HIV interactions (irrespective of whether a positive or negative interaction was found)
T410 16380-16611 Sentence denotes Although translational, “bench-to-bedside”, research is important, reverse-translational approaches and multiple preclinical models are essential to better understand complex disease and improve established therapies (Singer 2019).
T411 16612-16796 Sentence denotes Evidence suggests that HIV compartmentalizes within the CNS early during the course of the infection establishing a separate reservoir harboring “intact proviral” HIV (Churchill et al.
T412 16797-16816 Sentence denotes 2016; Bruner et al.
T413 16817-16877 Sentence denotes 2019) within resident neural cell populations (Bednar et al.
T414 16878-16901 Sentence denotes 2015; Sturdevant et al.
T415 16902-16923 Sentence denotes 2015; Veenhuis et al.
T416 16924-16980 Sentence denotes 2019) and perivascular macrophages (Fischer-Smith et al.
T417 16981-16999 Sentence denotes 2001; Burdo et al.
T418 17000-17033 Sentence denotes 2013; Rappaport and Volsky 2015).
T419 17034-17334 Sentence denotes Preclinical studies assessing opioid interactions with HIV or viral proteins permit mechanistic understanding of how particular CNS cell types, including neurons, astroglia, and microglia are affected and contribute to accentuating effects of opiates on neuroHIV, which are discussed in detail below.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T17 441-445 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T18 467-490 Phenotype denotes peripheral neuropathies http://purl.obolibrary.org/obo/HP_0009830
T19 1455-1472 Phenotype denotes immune deficiency http://purl.obolibrary.org/obo/HP_0002721
T20 2823-2835 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T21 3207-3231 Phenotype denotes opportunistic infections http://purl.obolibrary.org/obo/HP_0031690
T22 3299-3307 Phenotype denotes dementia http://purl.obolibrary.org/obo/HP_0000726
T23 3661-3681 Phenotype denotes cognitive impairment http://purl.obolibrary.org/obo/HP_0100543
T24 4723-4727 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T25 4811-4815 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T26 5032-5044 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T27 6253-6269 Phenotype denotes hypersensitivity http://purl.obolibrary.org/obo/HP_0041092
T28 8581-8599 Phenotype denotes Sensory Neuropathy http://purl.obolibrary.org/obo/HP_0000763
T29 8617-8635 Phenotype denotes sensory neuropathy http://purl.obolibrary.org/obo/HP_0000763
T30 10186-10202 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T31 11119-11132 Phenotype denotes neuroblastoma http://purl.obolibrary.org/obo/HP_0003006
T32 11264-11277 Phenotype denotes demyelinating http://purl.obolibrary.org/obo/HP_0011096
T33 12893-12903 Phenotype denotes Neuropathy http://purl.obolibrary.org/obo/HP_0009830
T34 13002-13011 Phenotype denotes allodynia http://purl.obolibrary.org/obo/HP_0012533
T35 14104-14114 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T36 14218-14228 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T37 15101-15113 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T38 15153-15158 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273

2_test

Id Subject Object Predicate Lexical cue
32876803-9827765-62957912 171-175 9827765 denotes 1998
32876803-12394784-62957913 202-206 12394784 denotes 2002
32876803-17981630-62957914 223-227 17981630 denotes 2008
32876803-23392462-62957915 242-246 23392462 denotes 2013
32876803-15613188-62957916 551-555 15613188 denotes 1999
32876803-31658202-62957917 570-574 31658202 denotes 2019
32876803-30383590-62957918 753-757 30383590 denotes 2019
32876803-3041744-62957919 874-878 3041744 denotes 1988
32876803-1301643-62957920 905-909 1301643 denotes 1992
32876803-8237587-62957921 924-928 8237587 denotes 1993
32876803-8655291-62957922 945-949 8655291 denotes 1995
32876803-8985308-62957923 963-967 8985308 denotes 1996
32876803-22527633-62957924 1025-1029 22527633 denotes 2012
32876803-224107-62957925 1109-1113 224107 denotes 1979
32876803-6253568-62957926 1132-1136 6253568 denotes 1980
32876803-6783926-62957927 1138-1142 6783926 denotes 1981
32876803-3041744-62957928 1162-1166 3041744 denotes 1988
32876803-1950728-62957929 1183-1187 1950728 denotes 1991
32876803-1950730-62957930 1222-1226 1950730 denotes 1991
32876803-9610674-62957932 1263-1267 9610674 denotes 1998
32876803-12615205-62957933 1289-1293 12615205 denotes 2003
32876803-12894165-62957934 1308-1312 12894165 denotes 2003
32876803-18040793-62957935 1325-1329 18040793 denotes 2006
32876803-18397920-62957936 1346-1350 18397920 denotes 2008
32876803-9610676-62957937 1509-1513 9610676 denotes 1998
32876803-2174676-62957938 1610-1614 2174676 denotes 1990
32876803-1460095-62957939 1616-1620 1460095 denotes 1992
32876803-8237594-62957940 1622-1626 8237594 denotes 1993
32876803-10218868-62957941 1628-1632 10218868 denotes 1999
32876803-14560041-62957942 1644-1648 14560041 denotes 2003
32876803-23682308-62957943 1744-1748 23682308 denotes 2013
32876803-27720326-62957944 1764-1768 27720326 denotes 2016
32876803-24401274-62957945 1796-1800 24401274 denotes 2014
32876803-11268344-62957946 1912-1916 11268344 denotes 2000
32876803-12615205-62957947 1938-1942 12615205 denotes 2003
32876803-12726730-62957948 1958-1962 12726730 denotes 2003
32876803-14729105-62957949 1976-1980 14729105 denotes 2004
32876803-21454526-62957950 1994-1998 21454526 denotes 2011
32876803-27720326-62957951 2014-2018 27720326 denotes 2016
32876803-12425430-62957952 2102-2106 12425430 denotes 2002
32876803-12726730-62957953 2122-2126 12726730 denotes 2003
32876803-25338959-62957954 2155-2159 25338959 denotes 2014
32876803-18040811-62957955 2253-2257 18040811 denotes 2006
32876803-9610676-62957956 2705-2709 9610676 denotes 1998
32876803-15577659-62957957 2725-2729 15577659 denotes 2004
32876803-24388495-62957958 2748-2752 24388495 denotes 2014
32876803-25834861-62957959 2754-2758 25834861 denotes 2015
32876803-9827765-62957960 2856-2860 9827765 denotes 1998
32876803-12394781-62957961 2862-2866 12394781 denotes 2002
32876803-24388495-62957962 3041-3045 24388495 denotes 2014
32876803-10945813-62957963 3402-3406 10945813 denotes 2000
32876803-20517932-62957964 3424-3428 20517932 denotes 2010
32876803-26965674-62957965 3444-3448 26965674 denotes 2016
32876803-15885069-62957966 3612-3616 15885069 denotes 2005
32876803-18040783-62957967 3630-3634 18040783 denotes 2006
32876803-17981630-62957968 3651-3655 17981630 denotes 2008
32876803-16783132-62957969 3708-3712 16783132 denotes 2006
32876803-19468837-62957970 3740-3744 19468837 denotes 2009
32876803-21725250-62957971 3758-3762 21725250 denotes 2011
32876803-29781879-62957972 3816-3820 29781879 denotes 2018
32876803-1745346-62957973 3917-3921 1745346 denotes 1991
32876803-19890760-62957974 3940-3944 19890760 denotes 2010
32876803-31259761-62957975 3969-3973 31259761 denotes 2019
32876803-15000697-62957976 4060-4064 15000697 denotes 2004
32876803-15885069-62957977 4167-4171 15885069 denotes 2005
32876803-17981630-62957978 4173-4177 17981630 denotes 2008
32876803-19519229-62957979 4236-4240 19519229 denotes 2009
32876803-21725250-62957980 4254-4258 21725250 denotes 2011
32876803-23392462-62957981 4273-4277 23392462 denotes 2013
32876803-21725250-62957982 4340-4344 21725250 denotes 2011
32876803-30383590-62957984 4946-4950 30383590 denotes 2019
32876803-24388495-62957985 5022-5026 24388495 denotes 2014
32876803-9827765-62957986 5182-5186 9827765 denotes 1998
32876803-12394781-62957987 5435-5439 12394781 denotes 2002
32876803-15885069-62957988 5528-5532 15885069 denotes 2005
32876803-15000697-62957989 5823-5827 15000697 denotes 2004
32876803-25834861-62957990 5982-5986 25834861 denotes 2015
32876803-8300019-62957991 6127-6131 8300019 denotes 1993
32876803-1938173-62957992 6349-6353 1938173 denotes 1991
32876803-23392462-62957993 6496-6500 23392462 denotes 2013
32876803-21725250-62957994 6587-6591 21725250 denotes 2011
32876803-9057169-62957995 6712-6716 9057169 denotes 1997
32876803-19890760-62957996 6811-6815 19890760 denotes 2010
32876803-29781879-62957997 6967-6971 29781879 denotes 2018
32876803-9649966-62957998 7372-7376 9649966 denotes 1998
32876803-11391170-62957999 7475-7479 11391170 denotes 2001
32876803-8112557-62958000 7691-7695 8112557 denotes 1993
32876803-30312275-62958001 7789-7793 30312275 denotes 2018
32876803-22391864-62958002 7985-7989 22391864 denotes 2012
32876803-21070507-62958003 8162-8166 21070507 denotes 2012
32876803-22457278-62958004 8271-8275 22457278 denotes 2012
32876803-23392455-62958005 8575-8579 23392455 denotes 2013
32876803-20851521-62958006 8709-8713 20851521 denotes 2010
32876803-16876224-62958007 8960-8964 16876224 denotes 2006
32876803-21431470-62958008 9132-9136 21431470 denotes 2011
32876803-17725417-62958009 9356-9360 17725417 denotes 2007
32876803-17934700-62958010 9384-9388 17934700 denotes 2008
32876803-17011009-62958013 9974-9978 17011009 denotes 2007
32876803-17064752-62958014 10133-10137 17064752 denotes 2007
32876803-24074576-62958015 10153-10157 24074576 denotes 2013
32876803-21748284-62958016 10385-10389 21748284 denotes 2011
32876803-22591370-62958017 10499-10503 22591370 denotes 2012
32876803-18247128-62958018 11359-11363 18247128 denotes 2008
32876803-20938808-62958019 11590-11594 20938808 denotes 2011
32876803-17553897-62958020 12311-12315 17553897 denotes 2007
32876803-29465625-62958021 13062-13066 29465625 denotes 2018
32876803-27039332-62958022 13732-13736 27039332 denotes 2016
32876803-18784333-62958023 14612-14616 18784333 denotes 2008
32876803-31668223-62958024 16605-16609 31668223 denotes 2019
32876803-26616417-62958025 16797-16801 26616417 denotes 2016
32876803-30700913-62958026 16817-16821 30700913 denotes 2019
32876803-25914150-62958027 16878-16882 25914150 denotes 2015
32876803-25811757-62958028 16902-16906 25811757 denotes 2015
32876803-30734905-62958029 16924-16928 30734905 denotes 2019
32876803-23772617-62958030 17000-17004 23772617 denotes 2013