PMC:7463108 / 109385-110420
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T66 | 0-3 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T67 | 27-36 | Body_part | denotes | microglia | http://purl.org/sig/ont/fma/fma68923 |
| T68 | 54-65 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T69 | 77-82 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T70 | 100-110 | Body_part | denotes | astrocytes | http://purl.org/sig/ont/fma/fma54537 |
| T71 | 116-125 | Body_part | denotes | pericytes | http://purl.org/sig/ont/fma/fma63174 |
| T72 | 357-368 | Body_part | denotes | neural cell | http://purl.org/sig/ont/fma/fma70333 |
| T73 | 364-368 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T74 | 397-402 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T75 | 607-615 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T76 | 624-635 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T77 | 725-735 | Body_part | denotes | astrocytes | http://purl.org/sig/ont/fma/fma54537 |
| T78 | 822-832 | Body_part | denotes | astrocytes | http://purl.org/sig/ont/fma/fma54537 |
| T79 | 988-997 | Body_part | denotes | microglia | http://purl.org/sig/ont/fma/fma68923 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T209 | 77-82 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T210 | 259-268 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T86 | 27-36 | http://purl.obolibrary.org/obo/CL_0000129 | denotes | microglia |
| T87 | 77-82 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T88 | 77-82 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T89 | 100-110 | http://purl.obolibrary.org/obo/CL_0000127 | denotes | astrocytes |
| T90 | 364-374 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell types |
| T91 | 397-402 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T92 | 607-615 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T93 | 642-643 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T94 | 725-735 | http://purl.obolibrary.org/obo/CL_0000127 | denotes | astrocytes |
| T95 | 771-772 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T96 | 822-832 | http://purl.obolibrary.org/obo/CL_0000127 | denotes | astrocytes |
| T97 | 988-997 | http://purl.obolibrary.org/obo/CL_0000129 | denotes | microglia |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T25269 | 308-313 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T54061 | 439-449 | Chemical | denotes | nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
| T71638 | 450-482 | Chemical | denotes | reverse transcriptase inhibitors | http://purl.obolibrary.org/obo/CHEBI_53756|http://purl.obolibrary.org/obo/CHEBI_59897 |
| T38912 | 458-482 | Chemical | denotes | transcriptase inhibitors | http://purl.obolibrary.org/obo/CHEBI_37416 |
| T147 | 472-482 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T31350 | 499-509 | Chemical | denotes | nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
| T149 | 510-542 | Chemical | denotes | reverse transcriptase inhibitors | http://purl.obolibrary.org/obo/CHEBI_53756|http://purl.obolibrary.org/obo/CHEBI_59897 |
| T20701 | 518-542 | Chemical | denotes | transcriptase inhibitors | http://purl.obolibrary.org/obo/CHEBI_37416 |
| T94314 | 532-542 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T20334 | 648-653 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T8519 | 869-878 | Chemical | denotes | darunavir | http://purl.obolibrary.org/obo/CHEBI_367163 |
| T1783 | 883-894 | Chemical | denotes | raltegravir | http://purl.obolibrary.org/obo/CHEBI_82960 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 3671 | 0-3 | Species | denotes | HIV | Tax:12721 |
| 3672 | 869-878 | Chemical | denotes | darunavir | MESH:D000069454 |
| 3673 | 883-894 | Chemical | denotes | raltegravir | MESH:D000068898 |
| 3674 | 138-146 | Disease | denotes | infected | MESH:D007239 |
| 3675 | 259-268 | Disease | denotes | infection | MESH:D007239 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T33 | 458-471 | http://purl.obolibrary.org/obo/GO_0003968 | denotes | transcriptase |
| T34 | 458-471 | http://purl.obolibrary.org/obo/GO_0003899 | denotes | transcriptase |
| T35 | 518-531 | http://purl.obolibrary.org/obo/GO_0003968 | denotes | transcriptase |
| T36 | 518-531 | http://purl.obolibrary.org/obo/GO_0003899 | denotes | transcriptase |
| T37 | 571-599 | http://purl.obolibrary.org/obo/GO_1903901 | denotes | inhibiting viral replication |
| T38 | 582-599 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T39 | 582-599 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T40 | 692-717 | http://purl.obolibrary.org/obo/GO_1903901 | denotes | inhibit viral replication |
| T41 | 700-717 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T42 | 700-717 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1369 | 0-170 | Sentence | denotes | HIV preferentially infects microglia and perivascular macrophages within the brain, although BMECs, astrocytes, and pericytes can also be infected (Kramer-Hammerle et al. |
| T1370 | 171-177 | Sentence | denotes | 2005). |
| T1371 | 178-269 | Sentence | denotes | Achieving optimal intracellular ARV concentrations are essential to suppress the infection. |
| T1372 | 270-429 | Sentence | denotes | Few studies have examined whether ARV drugs differentially accumulate within different neural cell types and especially within cells of the neurovascular unit. |
| T1373 | 430-748 | Sentence | denotes | Although nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are efficacious in inhibiting viral replication within monocyte-derived macrophages, only a few drugs within each ARV class can effectively inhibit viral replication within astrocytes (Gray et al. |
| T1374 | 749-833 | Sentence | denotes | 2013), which could be a result of poor intracellular accumulation within astrocytes. |
| T1375 | 834-1028 | Sentence | denotes | In vitro studies have demonstrated darunavir and raltegravir intracellular concentrations to be approximately 100-fold lower (with higher EC50 values) in microglia than in PBMCs (Asahchop et al. |
| T1376 | 1029-1035 | Sentence | denotes | 2017). |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32876803-15885841-62958392 | 171-175 | 15885841 | denotes | 2005 |
| 32876803-23614033-62958393 | 749-753 | 23614033 | denotes | 2013 |
| 32876803-29037245-62958394 | 1029-1033 | 29037245 | denotes | 2017 |