PMC:7463108 / 106191-106492 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"The boosted protease inhibitor combination, atazanavir/ritonavir, inhibits CYP 3A4 and UGT 1A1, leading to increases in overall systemic exposure of buprenorphine and norbuprenorphine and also results in symptoms of opioid excess, such as increased sedation and impaired cognition (McCance-Katz et al.","tracks":[{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T91","span":{"begin":12,"end":30},"obj":"Chemical"},{"id":"T93","span":{"begin":21,"end":30},"obj":"Chemical"},{"id":"T84290","span":{"begin":44,"end":54},"obj":"Chemical"},{"id":"T94858","span":{"begin":55,"end":64},"obj":"Chemical"},{"id":"T64009","span":{"begin":75,"end":78},"obj":"Chemical"},{"id":"T31065","span":{"begin":149,"end":162},"obj":"Chemical"}],"attributes":[{"id":"A67777","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_37670"},{"id":"A2159","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_60258"},{"id":"A27095","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A3788","pred":"chebi_id","subj":"T84290","obj":"http://purl.obolibrary.org/obo/CHEBI_37924"},{"id":"A92040","pred":"chebi_id","subj":"T94858","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A36824","pred":"chebi_id","subj":"T64009","obj":"http://purl.obolibrary.org/obo/CHEBI_38559"},{"id":"A93307","pred":"chebi_id","subj":"T31065","obj":"http://purl.obolibrary.org/obo/CHEBI_3216"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T84290","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T94858","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T64009","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31065","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"3597","span":{"begin":75,"end":82},"obj":"Gene"},{"id":"3598","span":{"begin":87,"end":94},"obj":"Gene"},{"id":"3604","span":{"begin":44,"end":54},"obj":"Chemical"},{"id":"3605","span":{"begin":55,"end":64},"obj":"Chemical"},{"id":"3606","span":{"begin":149,"end":162},"obj":"Chemical"},{"id":"3607","span":{"begin":167,"end":183},"obj":"Chemical"}],"attributes":[{"id":"A3597","pred":"tao:has_database_id","subj":"3597","obj":"Gene:1576"},{"id":"A3598","pred":"tao:has_database_id","subj":"3598","obj":"Gene:54658"},{"id":"A3604","pred":"tao:has_database_id","subj":"3604","obj":"MESH:D000069446"},{"id":"A3605","pred":"tao:has_database_id","subj":"3605","obj":"MESH:D019438"},{"id":"A3606","pred":"tao:has_database_id","subj":"3606","obj":"MESH:D002047"},{"id":"A3607","pred":"tao:has_database_id","subj":"3607","obj":"MESH:C043585"},{"subj":"3597","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3598","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3604","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3605","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3606","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3607","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T24","span":{"begin":271,"end":280},"obj":"http://purl.obolibrary.org/obo/GO_0050890"}],"attributes":[{"subj":"T24","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1335","span":{"begin":0,"end":301},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1335","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-CHEBI","color":"#93daec","default":true},{"id":"LitCovid-PubTator","color":"#ece493"},{"id":"LitCovid-PD-GO-BP","color":"#c993ec"},{"id":"LitCovid-sentences","color":"#93ecaf"}]}]}}