PMC:7463108 / 101598-103588 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T25 146-149 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T26 1286-1296 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T27 1626-1629 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T28 1654-1663 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T29 1681-1691 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T30 1873-1881 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T27 636-637 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 675-676 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 744-748 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T30 793-796 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T31 1286-1296 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T32 1873-1881 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T51088 78-82 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T76461 223-227 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T96964 625-634 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T55392 647-654 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T75231 660-673 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T1452 689-696 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T55931 709-719 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T54595 768-777 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T51815 779-792 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T42352 1298-1305 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T52338 1467-1475 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T42965 1477-1486 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T60 1492-1505 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T67960 1530-1533 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T65348 1605-1613 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T94219 1778-1787 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T10937 1789-1798 Chemical denotes oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T56838 1800-1813 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T19929 1819-1824 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3507 723-726 Gene denotes KOR Gene:4986
3508 946-949 Gene denotes MOR Gene:4988
3509 1006-1009 Gene denotes MOR Gene:4988
3510 1327-1330 Gene denotes MOR Gene:4988
3511 1335-1338 Gene denotes KOR Gene:4986
3512 1565-1568 Gene denotes Tat Gene:6898
3513 638-641 Gene denotes MOR Gene:4988
3514 677-680 Gene denotes MOR Gene:4988
3515 1729-1733 Gene denotes Hage Gene:55510
3516 1696-1700 Gene denotes Hage Gene:55510
3517 1626-1631 Species denotes HIV-1 Tax:11676
3518 146-149 Species denotes HIV Tax:12721
3519 625-634 Chemical denotes methadone MESH:D008691
3520 660-673 Chemical denotes buprenorphine MESH:D002047
3521 768-777 Chemical denotes methadone MESH:D008691
3522 779-792 Chemical denotes buprenorphine MESH:D002047
3523 1467-1475 Chemical denotes morphine MESH:D009020
3524 1477-1486 Chemical denotes methadone MESH:D008691
3525 1492-1505 Chemical denotes buprenorphine MESH:D002047
3526 1530-1533 Chemical denotes ROS
3527 1539-1543 Chemical denotes Ca2+ MESH:D000069285
3528 1605-1613 Chemical denotes Morphine MESH:D009020
3529 1778-1787 Chemical denotes methadone MESH:D008691
3530 1789-1798 Chemical denotes oxycodone MESH:D010098
3531 1800-1813 Chemical denotes buprenorphine MESH:D002047
3532 236-245 Disease denotes mortality MESH:D003643
3533 284-299 Disease denotes opioid overdose MESH:D062787
3534 856-860 Disease denotes ARVs
3535 877-903 Disease denotes opioid withdrawal symptoms MESH:D013375
3536 1124-1134 Disease denotes neurotoxic MESH:D020258

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T12 432-438 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T13 432-438 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T14 443-452 http://purl.obolibrary.org/obo/GO_0051235 denotes retention

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1276 0-129 Sentence denotes Opioid substitution therapies significantly reduce the frequency of injection drug use (Kwiatkowski and Booth 2001; Pettes et al.
T1277 130-185 Sentence denotes 2010), decrease HIV transmission risk (MacArthur et al.
T1278 186-204 Sentence denotes 2012; Platt et al.
T1279 205-261 Sentence denotes 2016), and reduce drug-related mortality (Mathers et al.
T1280 262-314 Sentence denotes 2013) and the risk of opioid overdose (Volkow et al.
T1281 315-321 Sentence denotes 2014).
T1282 322-522 Sentence denotes Further, improved ARV outcomes among PWH have been reported with opioid substitution therapies, including the uptake and retention on ARV, medication adherence rates, and viral suppression (Low et al.
T1283 523-547 Sentence denotes 2016; Mukandavire et al.
T1284 548-554 Sentence denotes 2017).
T1285 555-750 Sentence denotes The two main medications used for opioid substitution therapy include methadone, a MOR full agonist, and buprenorphine, a MOR partial agonist and partial antagonist of KOR (Noble and Marie 2018).
T1286 751-1031 Sentence denotes In comparison to methadone, buprenorphine has been shown to have fewer pharmacodynamic interactions with ARVs and causes less opioid withdrawal symptoms potentially due to its partial agonism on MOR, but also due to its high affinity and long duration of MOR binding (Walsh et al.
T1287 1032-1081 Sentence denotes 1994; McCance-Katz 2005; Whelan and Remski 2012).
T1288 1082-1203 Sentence denotes Further, differential proinflammatory and neurotoxic effects have been noted for various opioid treatments (Boland et al.
T1289 1204-1224 Sentence denotes 2014; Fitting et al.
T1290 1225-1247 Sentence denotes 2014b; Carvallo et al.
T1291 1248-1274 Sentence denotes 2015; Dutta and Roy 2015).
T1292 1275-1379 Sentence denotes In primary astrocytes, agonist-selective actions at MOR and KOR can be clearly demonstrated (Bohn et al.
T1293 1380-1401 Sentence denotes 2000; Belcheva et al.
T1294 1402-1423 Sentence denotes 2003; McLennan et al.
T1295 1424-1441 Sentence denotes 2008; Hahn et al.
T1296 1442-1596 Sentence denotes 2010), and we found that morphine, methadone, and buprenorphine differentially increase ROS and [Ca2+]i alone or following Tat co-exposure (Fitting et al.
T1297 1597-1604 Sentence denotes 2014b).
T1298 1605-1707 Sentence denotes Morphine can enhance HIV-1-induced production of cytokines and specifically chemokines (El-Hage et al.
T1299 1708-1740 Sentence denotes 2008a; Dave 2012; El-Hage et al.
T1300 1741-1906 Sentence denotes 2014), while other opioids including methadone, oxycodone, buprenorphine, and DAMGO can decrease inflammatory function and decrease monocyte migration (Boland et al.
T1301 1907-1928 Sentence denotes 2014; Carvallo et al.
T1302 1929-1961 Sentence denotes 2015; Jaureguiberry-Bravo et al.
T1303 1962-1983 Sentence denotes 2016; Chilunda et al.
T1304 1984-1990 Sentence denotes 2019).

2_test

Id Subject Object Predicate Lexical cue
32876803-11391170-62958348 110-114 11391170 denotes 2001
32876803-23038795-62958349 186-190 23038795 denotes 2012
32876803-23554523-62958350 262-266 23554523 denotes 2013
32876803-24758595-62958351 315-319 24758595 denotes 2014
32876803-27343545-62958352 523-527 27343545 denotes 2016
32876803-28323752-62958353 548-552 28323752 denotes 2017
32876803-30713510-62958354 744-748 30713510 denotes 2018
32876803-8181201-62958355 1032-1036 8181201 denotes 1994
32876803-16265622-62958356 1051-1055 16265622 denotes 2005
32876803-22346191-62958357 1075-1079 22346191 denotes 2012
32876803-24644198-62958358 1204-1208 24644198 denotes 2014
32876803-25716997-62958359 1248-1252 25716997 denotes 2015
32876803-19895666-62958360 1442-1446 19895666 denotes 2010
32876803-22066570-62958361 1720-1724 22066570 denotes 2012
32876803-24732776-62958362 1741-1745 24732776 denotes 2014
32876803-24644198-62958363 1907-1911 24644198 denotes 2014
32876803-25716997-62958364 1929-1933 25716997 denotes 2015
32876803-27009099-62958365 1962-1966 27009099 denotes 2016
32876803-31473221-62958366 1984-1988 31473221 denotes 2019