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PMC:7463108 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 98745-98761 Body_part denotes neurotransmitter http://purl.org/sig/ont/fma/fma302832
T2 98777-98781 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T3 99043-99060 Body_part denotes neurotransmitters http://purl.org/sig/ont/fma/fma302832
T4 99122-99130 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T5 99132-99141 Body_part denotes serotonin http://purl.org/sig/ont/fma/fma67245
T6 99171-99184 Body_part denotes acetylcholine http://purl.org/sig/ont/fma/fma61789
T7 99311-99316 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T8 99381-99395 Body_part denotes frontal cortex http://purl.org/sig/ont/fma/fma61824
T9 99401-99409 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T10 99437-99445 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T11 99450-99464 Body_part denotes norepinephrine http://purl.org/sig/ont/fma/fma61799
T12 99670-99678 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T13 99815-99818 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T14 99846-99854 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T15 99948-99956 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T16 99971-99979 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T17 99997-100005 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T18 100085-100093 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T19 100538-100547 Body_part denotes G protein http://purl.org/sig/ont/fma/fma61788
T20 100616-100620 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T21 100856-100860 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 100873-100876 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T23 100963-100967 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T24 101554-101557 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T25 101744-101747 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T26 102884-102894 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T27 103224-103227 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T28 103252-103261 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T29 103279-103289 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T30 103471-103479 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T31 104138-104142 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T32 104249-104259 Body_part denotes G proteins http://purl.org/sig/ont/fma/fma61788
T33 104423-104433 Body_part denotes G proteins http://purl.org/sig/ont/fma/fma61788
T34 104535-104538 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T35 104659-104662 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T36 104689-104698 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T37 105003-105012 Body_part denotes G protein http://purl.org/sig/ont/fma/fma61788
T38 105250-105253 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T39 105708-105711 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T40 106073-106077 Body_part denotes bile http://purl.org/sig/ont/fma/fma62971
T41 107584-107590 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T42 107654-107660 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T43 107682-107685 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T44 107759-107762 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T45 107773-107776 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T46 107816-107821 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T47 107909-107912 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T48 107935-107940 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T49 107941-107947 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T50 108107-108112 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T51 108113-108116 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T52 108211-108214 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T53 108222-108227 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T54 108313-108318 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T55 108337-108340 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T56 108431-108436 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T57 108460-108463 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T58 108522-108527 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T59 108528-108534 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T60 108668-108673 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T61 108795-108800 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T62 108882-108887 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T63 109242-109249 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 109320-109325 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T65 109367-109370 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T66 109385-109388 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T67 109412-109421 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T68 109439-109450 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T69 109462-109467 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T70 109485-109495 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T71 109501-109510 Body_part denotes pericytes http://purl.org/sig/ont/fma/fma63174
T72 109742-109753 Body_part denotes neural cell http://purl.org/sig/ont/fma/fma70333
T73 109749-109753 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T74 109782-109787 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 109992-110000 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T76 110009-110020 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T77 110110-110120 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T78 110207-110217 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T79 110373-110382 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T80 110535-110545 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T81 110547-110556 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T82 110558-110567 Body_part denotes pericytes http://purl.org/sig/ont/fma/fma63174
T83 110695-110700 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T84 110701-110705 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T85 110783-110787 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 110993-111003 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T87 111355-111360 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T36418 237-240 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T60544 261-283 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T59550 285-288 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T34528 438-441 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T34449 615-618 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T43923 656-660 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T63421 804-807 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T26171 837-840 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T51689 853-857 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T88958 1049-1052 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T13436 1239-1242 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T69159 1310-1313 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T39171 1314-1323 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T64264 1549-1554 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T26336 1555-1560 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T43402 1602-1605 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T14505 1688-1702 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T96043 1703-1711 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T51030 1769-1774 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T69233 1892-1897 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T28385 3155-3158 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T75294 3179-3182 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T79522 3343-3346 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T9454 3569-3572 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T50043 5791-5813 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T17352 5815-5818 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T59163 6748-6751 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T77573 6814-6819 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T11544 7009-7016 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T53542 7053-7058 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T32601 7129-7140 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T1467 7166-7178 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T78741 7373-7382 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T8526 7428-7432 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T98643 7592-7599 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T39647 7964-7967 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T8863 7968-7975 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53390 8252-8273 Body_part denotes hippocampal formation http://purl.org/sig/ont/fma/fma74038
T3876 8290-8309 Body_part denotes Purkinje cell layer http://purl.org/sig/ont/fma/fma83896
T20293 8290-8303 Body_part denotes Purkinje cell http://purl.org/sig/ont/fma/fma67969
T85401 8299-8303 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T76845 8457-8464 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T87068 8569-8574 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T38234 8679-8692 Body_part denotes basal ganglia http://purl.org/sig/ont/fma/fma84013
T68160 8721-8738 Body_part denotes prefrontal cortex http://purl.org/sig/ont/fma/fma224850
T55578 8764-8776 Body_part denotes hypothalamus http://purl.org/sig/ont/fma/fma62008
T64557 9072-9080 Body_part denotes Glycogen http://purl.org/sig/ont/fma/fma82747
T92926 9125-9133 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T42648 9286-9301 Body_part denotes locus coeruleus http://purl.org/sig/ont/fma/fma72478
T92921 9311-9322 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T12225 9737-9749 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T62361 9765-9768 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T70209 10054-10057 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T54610 10074-10086 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T92740 10143-10149 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T88403 10190-10193 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T91823 10403-10412 Body_part denotes astrocyte http://purl.org/sig/ont/fma/fma54537
T67325 10443-10452 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T63785 10462-10479 Body_part denotes nucleus accumbens http://purl.org/sig/ont/fma/fma61889
T89876 10481-10484 Body_part denotes NAc http://purl.org/sig/ont/fma/fma61889
T49116 10840-10850 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T72974 10855-10864 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T35339 11495-11502 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64263 11657-11660 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T50792 12225-12228 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T99017 12291-12294 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T9482 12462-12465 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T12354 12525-12528 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T67899 12713-12716 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T43924 12793-12796 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T52247 13193-13198 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T7491 13946-13949 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T33611 13972-13977 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T479 14057-14060 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T92463 14546-14549 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T48606 14648-14652 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T1997 15204-15207 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T9687 15345-15348 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T82777 15669-15672 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T78472 15724-15727 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T58755 15765-15769 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T34298 16334-16338 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T62955 16519-16522 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T46418 16793-16796 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T35666 16849-16852 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T82002 16944-16947 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T12185 17029-17032 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T88 17066-17069 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T89 17233-17236 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T90 17337-17340 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T91 17413-17416 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T92 17437-17440 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T93 17451-17454 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T94 17455-17458 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T95 17512-17517 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T96 17522-17525 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T97 17548-17553 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T98 17595-17598 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T99 17660-17663 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T100 17687-17692 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T101 17713-17716 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T102 17826-17829 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T103 17851-17854 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T104 17891-17896 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T105 17919-17922 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T106 17980-17983 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T107 17989-17992 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T108 18056-18061 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T109 18081-18087 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T110 18088-18097 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T111 18098-18101 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T112 18182-18188 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T113 18214-18217 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T114 18277-18282 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T115 18337-18342 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T116 18378-18381 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T117 18439-18442 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T118 18488-18493 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T119 18544-18547 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T120 18688-18691 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T121 18756-18759 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T122 18887-18890 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T123 18978-18981 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T124 19083-19089 Body_part denotes Concha http://purl.org/sig/ont/fma/fma61006
T125 19221-19224 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T126 19384-19387 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T127 19446-19449 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T128 19515-19518 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T129 19618-19621 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T130 19721-19724 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T131 19781-19784 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T132 19866-19869 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T133 19977-19980 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T134 20005-20011 Body_part denotes Finger http://purl.org/sig/ont/fma/fma9666
T135 20096-20099 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T136 20196-20199 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T137 20244-20247 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T138 20259-20262 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T139 20275-20278 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T140 20349-20354 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T141 20413-20416 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T142 20553-20556 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T143 20600-20603 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T144 20662-20665 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T145 20795-20800 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T146 20849-20852 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T147 20904-20907 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T148 20985-20988 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T149 20998-21001 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T150 21138-21141 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T151 21157-21162 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T152 21257-21260 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T153 21420-21425 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T154 21430-21433 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T155 21479-21484 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T156 21539-21542 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T157 21779-21783 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T158 22320-22323 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T159 22544-22552 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T160 22594-22597 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T161 22776-22779 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T162 22816-22822 Body_part denotes neuron http://purl.org/sig/ont/fma/fma54527
T163 22832-22835 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T164 22855-22858 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T165 22894-22897 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T166 22968-22972 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T167 23020-23026 Body_part denotes neuron http://purl.org/sig/ont/fma/fma54527
T168 23066-23076 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T169 23108-23115 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T170 23117-23127 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T171 23428-23435 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 23456-23460 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T173 23518-23523 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T174 23556-23568 Body_part denotes White matter http://purl.org/sig/ont/fma/fma83929
T175 23675-23686 Body_part denotes Macrophages http://purl.org/sig/ont/fma/fma63261
T176 23699-23705 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T177 23751-23754 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T178 23882-23894 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T179 23921-23933 Body_part denotes Myo-inositol http://purl.org/sig/ont/fma/fma82800
T180 23937-23944 Body_part denotes putamen http://purl.org/sig/ont/fma/fma61834
T181 24065-24074 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T182 24114-24124 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T183 24212-24222 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T184 24256-24267 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T185 24268-24277 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T186 24370-24379 Body_part denotes Cytokines http://purl.org/sig/ont/fma/fma84050
T187 24381-24391 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T188 24392-24395 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T189 24568-24577 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T190 24622-24625 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T191 24656-24660 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T192 24667-24670 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T193 24727-24737 Body_part denotes G proteins http://purl.org/sig/ont/fma/fma61788
T194 24835-24838 Body_part denotes NAc http://purl.org/sig/ont/fma/fma61889
T195 24851-24859 Body_part denotes amygdala http://purl.org/sig/ont/fma/fma61841
T196 24874-24885 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T197 25162-25171 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T198 25406-25410 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T199 26325-26330 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T200 26331-26336 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T201 26397-26401 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T202 26419-26422 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T203 26459-26468 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T204 26475-26480 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T205 26509-26512 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T206 26533-26537 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T207 26585-26588 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T208 27161-27166 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T209 27167-27172 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T210 27232-27239 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T211 27256-27263 Body_part denotes putamen http://purl.org/sig/ont/fma/fma61834
T212 27265-27268 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T213 27270-27292 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T214 27353-27356 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T215 27358-27377 Body_part denotes cerebrospinal fluid http://purl.org/sig/ont/fma/fma20935
T216 27412-27422 Body_part denotes enkephalin http://purl.org/sig/ont/fma/fma83367
T217 27438-27455 Body_part denotes dopamine receptor http://purl.org/sig/ont/fma/fma61811
T218 27482-27485 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T219 27551-27558 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T220 27702-27705 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T221 27939-27956 Body_part denotes prefrontal cortex http://purl.org/sig/ont/fma/fma224850
T222 28231-28234 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T223 28395-28398 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T224 28410-28444 Body_part denotes peripheral blood mononuclear cells http://purl.org/sig/ont/fma/fma86713
T225 28439-28444 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T226 28469-28480 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T227 28485-28494 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T228 28524-28546 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T229 28562-28565 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T230 28604-28629 Body_part denotes peripheral nervous system http://purl.org/sig/ont/fma/fma9903
T231 28677-28680 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T232 29020-29023 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T233 29053-29056 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T234 29160-29163 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T235 29224-29235 Body_part denotes neural cell http://purl.org/sig/ont/fma/fma70333
T236 29231-29235 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T237 29332-29343 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T238 29474-29477 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T239 29487-29495 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T240 29547-29550 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T241 29551-29555 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T242 29573-29580 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T243 29597-29606 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T244 29771-29780 Body_part denotes Microglia http://purl.org/sig/ont/fma/fma68923
T245 29786-29793 Body_part denotes Neurons http://purl.org/sig/ont/fma/fma54527
T246 29879-29886 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T247 29891-29895 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T248 30054-30076 Body_part denotes enteric nervous system http://purl.org/sig/ont/fma/fma66070
T249 30119-30122 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T250 30281-30285 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T251 30296-30301 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T252 30466-30469 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T253 30470-30474 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T254 30589-30592 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T255 30665-30669 Body_part denotes Glia http://purl.org/sig/ont/fma/fma54541
T256 30670-30673 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T257 30685-30688 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T258 30733-30736 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T259 30791-30795 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T260 30800-30807 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T261 30820-30832 Body_part denotes neural cells http://purl.org/sig/ont/fma/fma70333
T262 30827-30832 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T263 30834-30837 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T264 30847-30858 Body_part denotes promonocyte http://purl.org/sig/ont/fma/fma83551
T265 31003-31006 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T266 31032-31039 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T267 31044-31048 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T268 31069-31079 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T269 31182-31186 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T270 31240-31243 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T271 31326-31336 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T272 31377-31381 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T273 31546-31550 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T274 31788-31797 Body_part denotes Astrocyte http://purl.org/sig/ont/fma/fma54537
T275 31844-31848 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T276 31938-31946 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T277 31979-31983 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T278 32027-32034 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T279 32039-32043 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T280 32062-32065 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T281 32188-32191 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T282 32224-32233 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T283 32297-32300 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T284 32335-32340 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T285 32356-32366 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T286 32371-32380 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T287 32391-32396 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T288 32436-32439 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T289 32476-32483 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T290 32526-32529 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T291 32544-32548 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T292 32718-32728 Body_part denotes Astrocytes http://purl.org/sig/ont/fma/fma54537
T293 32729-32732 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T294 32774-32777 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T295 32806-32816 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T296 33007-33017 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T297 33041-33051 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T298 33123-33133 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T299 33234-33244 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T300 33427-33437 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T301 33569-33579 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T302 33676-33680 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T303 33695-33705 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T304 33786-33794 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T305 33855-33865 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T306 34016-34021 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T307 34022-34026 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T308 34197-34201 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T309 34211-34221 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T310 34247-34257 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T311 34277-34286 Body_part denotes Microglia http://purl.org/sig/ont/fma/fma68923
T312 34287-34290 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T313 34371-34374 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T314 34484-34493 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T315 34545-34548 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T316 34568-34577 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T317 34671-34674 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T318 34694-34703 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T319 34767-34770 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T320 34786-34789 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T321 34828-34832 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T322 34857-34866 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T323 35030-35033 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T324 35041-35052 Body_part denotes fetal brain http://purl.org/sig/ont/fma/fma312981
T325 35053-35062 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T326 35227-35238 Body_part denotes fetal brain http://purl.org/sig/ont/fma/fma312981
T327 35239-35248 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T328 35259-35266 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T329 35267-35271 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T330 35292-35295 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T331 35428-35437 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T332 35451-35460 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T333 35465-35477 Body_part denotes neural cells http://purl.org/sig/ont/fma/fma70333
T334 35472-35477 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T335 35497-35507 Body_part denotes Chemokines http://purl.org/sig/ont/fma/fma241981
T336 35512-35521 Body_part denotes Cytokines http://purl.org/sig/ont/fma/fma84050
T337 35629-35638 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T338 35727-35731 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T339 35754-35763 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T340 35875-35882 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T341 35915-35924 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T342 36087-36096 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T343 36117-36124 Body_part denotes Neurons http://purl.org/sig/ont/fma/fma54527
T344 36125-36128 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T345 36140-36143 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T346 36158-36161 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T347 36210-36215 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T348 36345-36354 Body_part denotes Dendritic http://purl.org/sig/ont/fma/fma67314
T349 36383-36390 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T350 36617-36624 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T351 36656-36663 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T352 36694-36701 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T353 36725-36730 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T354 36780-36788 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T355 36822-36830 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T356 36964-36971 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T357 36982-36986 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T358 37193-37201 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T359 37215-37223 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T360 37332-37339 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T361 37350-37354 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T362 37398-37410 Body_part denotes White matter http://purl.org/sig/ont/fma/fma83929
T363 37658-37663 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T364 37664-37669 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T365 37810-37818 Body_part denotes Monocyte http://purl.org/sig/ont/fma/fma62864
T366 37883-37893 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T367 38014-38024 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T368 38045-38048 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T369 38070-38078 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T370 38127-38135 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T371 38162-38166 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T372 38178-38188 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T373 38207-38216 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T374 38246-38253 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T375 38264-38268 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T376 38344-38352 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T377 38377-38381 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T378 38497-38504 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T379 38515-38519 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T380 38606-38621 Body_part denotes oligodendroglia http://purl.org/sig/ont/fma/fma83665
T381 38749-38752 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T382 38778-38781 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T383 38801-38804 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T384 38830-38833 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T385 39068-39071 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T386 39138-39145 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T387 39408-39415 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T388 39420-39424 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T389 39435-39442 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T390 39444-39454 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T391 39459-39468 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T392 39618-39623 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T393 39633-39650 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T394 39645-39650 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T395 39763-39773 Body_part denotes enkephalin http://purl.org/sig/ont/fma/fma83367
T396 39896-39906 Body_part denotes enkephalin http://purl.org/sig/ont/fma/fma83367
T397 40292-40297 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T398 40304-40319 Body_part denotes oligodendroglia http://purl.org/sig/ont/fma/fma83665
T399 40559-40562 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T400 40723-40726 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T401 40760-40771 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T402 40776-40785 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T403 40815-40837 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T404 40853-40856 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T405 40895-40920 Body_part denotes peripheral nervous system http://purl.org/sig/ont/fma/fma9903
T406 40968-40971 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T407 41068-41071 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T408 41300-41303 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T409 41431-41441 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T410 41578-41581 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T411 41616-41626 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T412 41630-41633 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T413 41643-41646 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T414 41647-41653 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T415 41828-41836 Body_part denotes synapses http://purl.org/sig/ont/fma/fma67408
T416 42022-42025 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T417 42029-42032 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T418 42033-42040 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T419 42049-42059 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T420 42100-42109 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T421 42155-42162 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T422 42285-42289 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T423 42302-42311 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T424 42379-42382 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T425 42537-42541 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T426 42543-42553 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T427 42558-42567 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T428 42646-42653 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T429 42875-42879 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T430 43106-43109 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T431 43141-43144 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T432 43160-43168 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T433 43300-43304 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T434 43377-43386 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T435 43515-43525 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T436 43540-43543 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T437 44109-44118 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T438 44136-44140 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T439 44177-44180 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T440 44256-44259 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T441 44372-44382 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T442 44484-44495 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T443 44496-44505 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T444 44833-44843 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T445 44894-44897 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T446 44908-44911 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T447 45002-45005 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T448 45099-45130 Body_part denotes glial fibrillary acidic protein http://purl.org/sig/ont/fma/fma63860
T449 45132-45136 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T451 45153-45163 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T452 45389-45392 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T453 45431-45435 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T455 45462-45473 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T456 45474-45483 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T457 45742-45752 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T458 45760-45771 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T459 45772-45781 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T460 46059-46070 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T461 46071-46080 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T462 46221-46225 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T464 46241-46251 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T465 46393-46396 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T466 46407-46410 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T467 46515-46525 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T468 46573-46582 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T469 46583-46594 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T470 46792-46802 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T471 46869-46880 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T472 46881-46890 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T473 47033-47036 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T474 47043-47046 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T475 47315-47318 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T476 47344-47353 Body_part denotes Microglia http://purl.org/sig/ont/fma/fma68923
T477 47364-47374 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T478 47387-47390 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T5102 47407-47416 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T480 47552-47561 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T481 47779-47788 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T482 47978-47987 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T483 48057-48065 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T484 48310-48319 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T485 48649-48652 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T486 48677-48686 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T487 48727-48735 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T488 48776-48784 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T489 49020-49029 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T490 49094-49097 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T491 49105-49108 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T492 49309-49318 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T493 49424-49427 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T494 49453-49460 Body_part denotes Neurons http://purl.org/sig/ont/fma/fma54527
T495 49482-49485 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T496 49573-49576 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T497 49616-49625 Body_part denotes dendritic http://purl.org/sig/ont/fma/fma67314
T498 49669-49676 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T499 49712-49716 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T500 49856-49865 Body_part denotes dendritic http://purl.org/sig/ont/fma/fma67314
T501 50243-50250 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T502 50589-50597 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T503 50756-50763 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T504 50776-50783 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T505 50906-50909 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T506 51546-51549 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T507 51622-51629 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T508 51703-51712 Body_part denotes dendrites http://purl.org/sig/ont/fma/fma67314
T509 51800-51813 Body_part denotes aspartic acid http://purl.org/sig/ont/fma/fma82760
T510 52419-52426 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T511 52562-52570 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T512 52673-52677 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T513 52761-52769 Body_part denotes Neuronal http://purl.org/sig/ont/fma/fma54527
T514 52792-52795 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T515 52817-52826 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T516 52974-52977 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T517 53008-53011 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T518 53077-53084 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T519 53186-53190 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T520 53384-53387 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T521 53402-53407 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T522 53408-53413 Body_part denotes Brain http://purl.org/sig/ont/fma/fma50801
T523 53493-53496 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T524 53538-53541 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T525 53598-53603 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T526 53604-53609 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T527 53681-53684 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T528 53783-53786 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T529 53788-53791 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T530 53812-53815 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T531 53816-53824 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T532 53858-53872 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T533 53873-53881 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T534 54318-54335 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T535 54330-54335 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T536 54508-54522 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T537 54523-54531 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T538 54920-54928 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T539 54940-54952 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T540 55374-55382 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T541 55504-55509 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T542 55524-55540 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T543 55536-55540 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T544 55552-55561 Body_part denotes astrocyte http://purl.org/sig/ont/fma/fma54537
T545 55671-55674 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T546 55893-55909 Body_part denotes zonula occludens http://purl.org/sig/ont/fma/fma67397
T547 55990-55997 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T548 56168-56171 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T549 56386-56391 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T550 56497-56502 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T551 56663-56670 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T552 56918-56921 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T553 57005-57013 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T554 57048-57053 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T555 57073-57076 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T556 57135-57140 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T557 57276-57281 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T558 58051-58062 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T559 58072-58090 Body_part denotes perivascular space http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272
T561 58098-58108 Body_part denotes parenchyma http://purl.org/sig/ont/fma/fma45732
T562 58116-58124 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T563 58203-58209 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T564 58270-58274 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T565 58407-58425 Body_part denotes perivascular space http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272
T567 58426-58436 Body_part denotes parenchyma http://purl.org/sig/ont/fma/fma45732
T568 58500-58509 Body_part denotes left-hand http://purl.org/sig/ont/fma/fma9714
T569 58602-58613 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T570 58614-58636 Body_part denotes post-capillary venules http://purl.org/sig/ont/fma/fma63191
T571 58619-58628 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T572 58738-58750 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T573 58831-58843 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T574 58862-58870 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T575 58997-59003 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T576 59007-59013 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T577 59024-59032 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T578 59185-59193 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T579 59278-59284 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T580 59288-59294 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T581 59485-59488 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T582 59490-59493 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T583 59502-59510 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T584 59596-59604 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T585 59613-59624 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T586 59641-59646 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T587 59689-59700 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T588 59710-59715 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T589 59850-59853 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T590 59875-59883 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T591 59915-59918 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T592 60158-60161 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T593 60194-60197 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T594 60220-60230 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T595 60481-60489 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T596 60535-60545 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T597 60694-60698 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T598 60720-60725 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T599 60809-60812 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T600 60867-60872 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T601 60932-60946 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T602 60947-60955 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T603 60988-60996 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T604 61050-61055 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T605 61070-61078 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T606 61120-61125 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T607 61197-61200 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T608 61245-61253 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T609 61265-61270 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T610 61378-61381 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T611 61403-61408 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T612 61478-61483 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T613 61484-61489 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T614 61607-61622 Body_part denotes tight junctions http://purl.org/sig/ont/fma/fma67397
T615 61751-61756 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T616 61834-61846 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T617 61892-61897 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T618 61951-61956 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T619 61976-61979 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T620 62065-62079 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T621 62080-62088 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T622 62146-62151 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T623 62255-62261 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T624 62280-62287 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T625 62324-62329 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T626 62447-62450 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T627 62476-62488 Body_part denotes White Matter http://purl.org/sig/ont/fma/fma83929
T628 62516-62519 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T629 62530-62542 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T630 62645-62649 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T631 62772-62784 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T632 62801-62805 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T633 62892-62904 Body_part denotes White matter http://purl.org/sig/ont/fma/fma83929
T634 63272-63275 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T635 63361-63377 Body_part denotes oligodendrocytes http://purl.org/sig/ont/fma/fma54540
T636 63458-63466 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T637 63836-63839 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T638 63946-63949 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T639 64039-64042 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T640 64096-64108 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T641 64271-64276 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T642 64485-64488 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T643 64614-64627 Body_part denotes aspartic acid http://purl.org/sig/ont/fma/fma82760
T644 65085-65095 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T645 65106-65113 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T646 65243-65255 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T647 65379-65385 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T648 65580-65600 Body_part denotes myelin basic protein http://purl.org/sig/ont/fma/fma242151
T649 65660-65667 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T650 66302-66314 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T651 66539-66545 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T652 66849-66860 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T653 66873-66879 Body_part denotes myelin http://purl.org/sig/ont/fma/fma62977
T654 67424-67427 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T655 67468-67471 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T656 67657-67667 Body_part denotes neuroblast http://purl.org/sig/ont/fma/fma70563
T657 67668-67672 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T658 67827-67830 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T659 68068-68071 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T660 68151-68154 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T661 68170-68177 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T662 68334-68345 Body_part denotes neuroblasts http://purl.org/sig/ont/fma/fma70563
T663 68457-68460 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T664 68488-68493 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T665 68712-68715 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T666 68765-68782 Body_part denotes neural stem cells http://purl.org/sig/ont/fma/fma86684
T667 68777-68782 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T668 68789-68792 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T669 69080-69083 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T670 69176-69186 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T671 69181-69186 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T672 69211-69218 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T673 69256-69269 Body_part denotes dentate gyrus http://purl.org/sig/ont/fma/fma61922
T674 69284-69287 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T675 69323-69332 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T676 69444-69449 Body_part denotes Notch http://purl.org/sig/ont/fma/fma75036
T677 69486-69490 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T678 69542-69549 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T679 69619-69627 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T680 69715-69718 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T681 69812-69815 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T682 69870-69883 Body_part denotes dentate gyrus http://purl.org/sig/ont/fma/fma61922
T683 69909-69912 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T684 69940-69947 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T685 69952-69956 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T686 70124-70128 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T687 70236-70243 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T688 70248-70252 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T689 70406-70409 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T690 70469-70476 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T691 70481-70485 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T692 70567-70570 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T693 70571-70574 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T694 70575-70583 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T695 70744-70754 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T696 70938-70942 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T697 70964-70975 Body_part denotes spinal cord http://purl.org/sig/ont/fma/fma7647
T698 71152-71156 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T699 71450-71453 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T700 71548-71551 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T701 71629-71632 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T702 71847-71852 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T703 71981-71988 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T704 71993-72003 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T705 72291-72294 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T706 72700-72703 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T707 72819-72830 Body_part denotes neural cell http://purl.org/sig/ont/fma/fma70333
T708 72826-72830 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T709 72841-72844 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T710 72908-72911 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T711 73085-73088 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T712 73521-73524 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T713 73539-73542 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T714 73580-73583 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T715 73624-73627 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T716 73836-73839 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T717 73872-73876 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T718 73983-73987 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T719 74165-74168 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T720 74178-74189 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T721 74554-74558 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T722 74779-74786 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T723 74909-74917 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T724 74977-74985 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T725 75017-75022 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T726 75212-75214 Body_part denotes A2 http://purl.org/sig/ont/fma/fma66595
T727 75227-75237 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T728 75528-75531 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T729 75737-75740 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T730 75839-75842 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T731 75860-75863 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T732 75949-75953 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T733 75981-75984 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T734 76009-76012 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T735 76047-76050 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T736 76376-76379 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T737 76423-76427 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T738 76488-76491 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T739 76657-76660 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T740 76707-76711 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T741 76774-76777 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T742 77018-77021 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T743 77138-77141 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T744 77180-77184 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T745 77250-77254 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T746 77321-77324 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T747 77552-77561 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T748 77628-77631 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T749 77816-77820 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T750 77847-77850 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T751 77998-78002 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T752 78087-78112 Body_part denotes neurotransmitter receptor http://purl.org/sig/ont/fma/fma67184
T753 78147-78150 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T754 78185-78189 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T755 78503-78506 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T756 78507-78516 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T757 78636-78639 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T758 78710-78713 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T759 78793-78797 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T760 78863-78866 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T761 78934-78937 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T762 79040-79043 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T763 79115-79119 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T764 79403-79411 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T765 79473-79478 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T766 79621-79624 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T767 79821-79824 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T768 79949-79970 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T769 80028-80037 Body_part denotes G Protein http://purl.org/sig/ont/fma/fma61788
T770 80030-80037 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T771 80107-80122 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T772 80285-80288 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T773 80289-80293 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T774 80322-80325 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T775 80616-80625 Body_part denotes Chemokine http://purl.org/sig/ont/fma/fma241981
T776 80697-80700 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T777 80715-80718 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T778 80830-80839 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T779 81190-81199 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T780 81408-81417 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T781 81682-81686 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T782 81891-81900 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T783 81933-81943 Body_part denotes enkephalin http://purl.org/sig/ont/fma/fma83367
T784 82045-82048 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T785 82428-82431 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T786 82451-82460 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T787 82529-82532 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T788 82649-82652 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T789 82695-82699 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T790 82717-82726 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T791 82754-82764 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T792 82805-82815 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T793 82860-82863 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T794 82941-82944 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T795 82958-82968 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T796 83091-83100 Body_part denotes astrocyte http://purl.org/sig/ont/fma/fma54537
T797 83232-83243 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T798 83244-83253 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T799 83426-83436 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T800 83449-83458 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T801 83496-83500 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T802 83662-83665 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T803 83705-83715 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T804 83724-83733 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T805 83842-83852 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T806 83857-83866 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T807 84033-84036 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T808 84046-84056 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T809 84112-84115 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T810 84151-84160 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T811 84335-84345 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T812 84376-84385 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T813 84425-84428 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T814 84590-84600 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T815 84613-84622 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T816 84723-84726 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T817 84742-84746 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T818 84848-84851 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T819 84871-84875 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T820 84935-84939 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T821 85109-85116 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T822 85145-85152 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T823 85446-85449 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T824 85466-85476 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T825 85485-85494 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T826 85689-85699 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T827 85704-85713 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T828 85814-85817 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T829 85827-85837 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T830 85923-85926 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T831 85942-85951 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T832 86097-86106 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T833 86112-86115 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T834 86295-86300 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T835 86319-86322 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T836 86646-86650 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T837 86660-86667 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T838 86822-86826 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T839 86836-86843 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T840 87182-87186 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T841 87297-87301 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T842 87562-87566 Body_part denotes Glia http://purl.org/sig/ont/fma/fma54541
T843 87616-87624 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T844 87743-87747 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T845 87863-87866 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T846 87876-87880 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T847 87955-87966 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T848 88027-88030 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T849 88289-88294 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T850 88412-88419 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T851 88503-88506 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T852 88584-88591 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T853 88616-88647 Body_part denotes glial fibrillary acidic protein http://purl.org/sig/ont/fma/fma63860
T854 88649-88653 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T856 88678-88688 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T857 88844-88848 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T858 88886-88889 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T859 88963-88967 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T860 89002-89006 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T861 89332-89336 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T862 89351-89358 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T863 90012-90016 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T864 90100-90104 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T865 90277-90286 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T866 90352-90356 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T867 90464-90468 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T868 90652-90656 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T869 90787-90791 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T870 91787-91790 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T871 92589-92592 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T872 92601-92605 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T873 92678-92687 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T874 92761-92764 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T875 92841-92844 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T876 92918-92921 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T877 92978-92981 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T878 93231-93234 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T879 94086-94090 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T880 94344-94347 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T881 94401-94405 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T882 94465-94476 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T883 94481-94485 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T884 94602-94612 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T885 94624-94635 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T886 94665-94676 Body_part denotes enkephalins http://purl.org/sig/ont/fma/fma83367
T887 94733-94742 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T888 94822-94834 Body_part denotes Granulocytes http://purl.org/sig/ont/fma/fma62854
T889 94953-94964 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T890 95032-95066 Body_part denotes peripheral blood mononuclear cells http://purl.org/sig/ont/fma/fma86713
T891 95061-95066 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T892 95215-95224 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T893 95234-95247 Body_part denotes interleukin-1 http://purl.org/sig/ont/fma/fma86583
T894 95250-95254 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T895 95363-95373 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T896 95398-95403 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T897 95509-95518 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T898 95558-95562 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T899 95592-95595 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T900 95601-95604 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T901 95664-95669 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T902 95706-95709 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T903 95768-95771 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T904 96137-96140 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T905 96229-96232 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T906 96343-96347 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T907 96389-96400 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T908 96405-96413 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T909 96498-96506 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T910 96516-96520 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T911 96535-96546 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T912 96631-96634 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T913 96746-96751 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T914 96757-96761 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T915 96804-96807 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T916 96867-96871 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T917 97054-97057 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T918 97470-97479 Body_part denotes pituitary http://purl.org/sig/ont/fma/fma13889
T919 97494-97498 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T920 97538-97546 Body_part denotes dopamine http://purl.org/sig/ont/fma/fma67238
T921 97657-97661 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T922 97663-97693 Body_part denotes corticotropin releasing factor http://purl.org/sig/ont/fma/fma83354
T923 98401-98405 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T924 98446-98449 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T925 98489-98493 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T926 98502-98505 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T927 98519-98527 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 261-283 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T2 269-283 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T3 285-288 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T4 1549-1568 Body_part denotes Blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T5 1555-1560 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T6 1769-1774 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T7 1892-1897 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T8 5791-5813 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T9 5799-5813 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T10 5815-5818 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T11 6814-6819 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T12 7053-7058 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T13 7166-7178 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T14 8252-8273 Body_part denotes hippocampal formation http://purl.obolibrary.org/obo/UBERON_0002421
T15 8299-8309 Body_part denotes cell layer http://purl.obolibrary.org/obo/UBERON_0000119
T16 8569-8574 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T17 8721-8738 Body_part denotes prefrontal cortex http://purl.obolibrary.org/obo/UBERON_0000451
T18 8732-8738 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T19 8764-8776 Body_part denotes hypothalamus http://purl.obolibrary.org/obo/UBERON_0001898
T20 9737-9749 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T21 9765-9768 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T22 10074-10086 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T23 10143-10149 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T24 10190-10193 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T25 10462-10479 Body_part denotes nucleus accumbens http://purl.obolibrary.org/obo/UBERON_0001882
T26 10481-10484 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T27 12525-12528 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T28 16519-16522 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T29 16849-16852 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T30 17451-17454 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T31 17548-17553 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T32 17687-17692 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T33 17891-17896 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T34 18056-18061 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T35 18277-18282 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T36 18488-18493 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T37 20005-20011 Body_part denotes Finger http://purl.obolibrary.org/obo/UBERON_0002389
T38 20349-20354 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T39 20795-20800 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T40 21157-21162 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T41 21479-21484 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T42 23556-23568 Body_part denotes White matter http://purl.obolibrary.org/obo/UBERON_0002316
T43 23699-23705 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T44 23751-23754 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T45 23882-23894 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T46 23937-23944 Body_part denotes putamen http://purl.obolibrary.org/obo/UBERON_0001874
T47 24835-24838 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T48 24839-24844 Body_part denotes Shell http://purl.obolibrary.org/obo/UBERON_0006612
T49 24851-24859 Body_part denotes amygdala http://purl.obolibrary.org/obo/UBERON_0001876
T50 25564-25568 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T51 26325-26344 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T52 26325-26330 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T53 26331-26336 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T54 26419-26422 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T55 26509-26512 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T56 26585-26588 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T57 27161-27180 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T58 27161-27166 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T59 27167-27172 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T60 27248-27263 Body_part denotes caudate-putamen http://purl.obolibrary.org/obo/UBERON_0005383
T61 27256-27263 Body_part denotes putamen http://purl.obolibrary.org/obo/UBERON_0001874
T62 27265-27268 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T63 27270-27292 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T64 27278-27292 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T65 27358-27377 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359
T66 27939-27956 Body_part denotes prefrontal cortex http://purl.obolibrary.org/obo/UBERON_0000451
T67 27950-27956 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T68 28231-28234 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T69 28421-28426 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T70 28524-28546 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T71 28532-28546 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T72 28604-28629 Body_part denotes peripheral nervous system http://purl.obolibrary.org/obo/UBERON_0000010
T73 28615-28629 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T74 29053-29056 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T75 29547-29550 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T76 30054-30076 Body_part denotes enteric nervous system http://purl.obolibrary.org/obo/UBERON_0002005
T77 30062-30076 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T78 30296-30301 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T79 30466-30469 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T80 34016-34021 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T81 35047-35052 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T82 35233-35238 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T83 37398-37410 Body_part denotes White matter http://purl.obolibrary.org/obo/UBERON_0002316
T84 37658-37677 Body_part denotes Blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T85 37664-37669 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T86 39618-39623 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T87 40559-40562 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T88 40815-40837 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T89 40823-40837 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T90 40895-40920 Body_part denotes peripheral nervous system http://purl.obolibrary.org/obo/UBERON_0000010
T91 40906-40920 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T92 41300-41303 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T93 41643-41646 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T94 41647-41653 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T95 44908-44911 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T96 45309-45314 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T97 46407-46410 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T98 49105-49108 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T99 53402-53421 Body_part denotes Blood-Brain Barrier http://purl.obolibrary.org/obo/UBERON_0000120
T100 53598-53617 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T101 53598-53603 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T102 53604-53609 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T103 53681-53684 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T104 53783-53786 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T105 55504-55509 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T106 56386-56391 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T107 56497-56502 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T108 56918-56921 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T109 57048-57053 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T110 57135-57140 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T111 57276-57281 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T112 58051-58062 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T113 58072-58090 Body_part denotes perivascular space http://purl.obolibrary.org/obo/UBERON_0014930
T114 58098-58108 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T115 58116-58124 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T116 58203-58209 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T117 58407-58425 Body_part denotes perivascular space http://purl.obolibrary.org/obo/UBERON_0014930
T118 58426-58436 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T119 58505-58509 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T120 58614-58636 Body_part denotes post-capillary venules http://purl.obolibrary.org/obo/UBERON_0035428
T121 58619-58628 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T122 58738-58750 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T123 58738-58743 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T124 58744-58750 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T125 58831-58843 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T126 58862-58870 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T127 58963-58968 Body_part denotes Scale http://purl.obolibrary.org/obo/UBERON_0002542
T128 58997-59003 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T129 59024-59032 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T130 59185-59193 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T131 59278-59284 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T132 59641-59646 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T133 59710-59715 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T134 59915-59918 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T135 60720-60725 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T136 60867-60872 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T137 61050-61055 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T138 61120-61125 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T139 61197-61200 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T140 61265-61270 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T141 61403-61408 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T142 61478-61497 Body_part denotes blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T143 61478-61483 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T144 61484-61489 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T145 61751-61756 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T146 61892-61897 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T147 61951-61956 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T148 62146-62151 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T149 62255-62261 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T150 62324-62329 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T151 62476-62488 Body_part denotes White Matter http://purl.obolibrary.org/obo/UBERON_0002316
T152 62530-62542 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T153 62772-62784 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T154 62892-62904 Body_part denotes White matter http://purl.obolibrary.org/obo/UBERON_0002316
T155 64096-64108 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T156 65243-65255 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T157 65379-65385 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T158 65580-65586 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T159 66302-66314 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T160 66539-66545 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T161 66873-66879 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345
T162 69264-69269 Body_part denotes gyrus http://purl.obolibrary.org/obo/UBERON_0000200
T163 69812-69815 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T164 69878-69883 Body_part denotes gyrus http://purl.obolibrary.org/obo/UBERON_0000200
T165 70964-70975 Body_part denotes spinal cord http://purl.obolibrary.org/obo/UBERON_0002240
T166 72841-72844 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T167 75017-75022 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T168 80285-80288 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T169 82649-82652 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T170 88860-88865 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T171 95043-95048 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T172 95398-95403 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T173 95664-95669 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T174 96229-96232 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T175 96405-96413 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T176 96498-96506 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T177 96746-96751 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T178 97054-97057 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T179 98502-98505 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T180 98812-98815 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T181 98816-98821 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T182 99311-99316 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T183 99376-99379 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T184 99381-99395 Body_part denotes frontal cortex http://purl.obolibrary.org/obo/UBERON_0001870
T185 99389-99395 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T186 99401-99409 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T187 99619-99622 Body_part denotes NAc http://purl.obolibrary.org/obo/UBERON_0001882
T188 99997-100005 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T189 100873-100876 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T190 105250-105253 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T191 105708-105711 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T192 106073-106077 Body_part denotes bile http://purl.obolibrary.org/obo/UBERON_0001970
T193 107654-107660 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T194 107682-107685 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T195 107816-107821 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T196 107935-107940 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T197 107941-107947 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T198 108107-108112 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T199 108222-108227 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T200 108313-108318 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T201 108431-108436 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T202 108522-108527 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T203 108528-108534 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T204 108668-108673 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T205 108795-108800 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T206 108882-108887 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T207 109320-109325 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T208 109367-109370 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T209 109462-109467 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T210 110695-110700 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 213-229 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T2 1958-1970 Disease denotes Opioid abuse http://purl.obolibrary.org/obo/MONDO_0001225
T3 3131-3147 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T4 3702-3710 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 3855-3863 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 3891-3900 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 3993-4005 Disease denotes opioid abuse http://purl.obolibrary.org/obo/MONDO_0001225
T8 4033-4043 Disease denotes depression http://purl.obolibrary.org/obo/MONDO_0002050
T9 4365-4373 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 5743-5755 Disease denotes Opioid Abuse http://purl.obolibrary.org/obo/MONDO_0001225
T11 5771-5783 Disease denotes opioid abuse http://purl.obolibrary.org/obo/MONDO_0001225
T12 6012-6030 Disease denotes sleep disturbances http://purl.obolibrary.org/obo/MONDO_0003406
T13 7053-7064 Disease denotes brain edema http://purl.obolibrary.org/obo/MONDO_0006684
T14 7675-7678 Disease denotes RNS http://purl.obolibrary.org/obo/MONDO_0009821|http://purl.obolibrary.org/obo/MONDO_0019105
T16 8119-8142 Disease denotes neurovascular disorders http://purl.obolibrary.org/obo/MONDO_0043218
T17 9856-9868 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T18 10601-10613 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T19 12155-12167 Disease denotes opioid abuse http://purl.obolibrary.org/obo/MONDO_0001225
T20 12852-12875 Disease denotes peripheral neuropathies http://purl.obolibrary.org/obo/MONDO_0003620
T21 13460-13478 Disease denotes immune suppression http://purl.obolibrary.org/obo/MONDO_0007816
T22 13831-13866 Disease denotes acquired immune deficiency syndrome http://purl.obolibrary.org/obo/MONDO_0012268
T23 13868-13872 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T24 15053-15057 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T25 15204-15220 Disease denotes HIV encephalitis http://purl.obolibrary.org/obo/MONDO_0020689
T26 15208-15220 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T27 15222-15226 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T28 15565-15569 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T29 15606-15616 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T30 15621-15625 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T31 15669-15692 Disease denotes HIV-associated dementia http://purl.obolibrary.org/obo/MONDO_0020689
T32 15684-15692 Disease denotes dementia http://purl.obolibrary.org/obo/MONDO_0001627
T33 16488-16497 Disease denotes tauopathy http://purl.obolibrary.org/obo/MONDO_0005574
T34 16523-16535 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T35 17413-17429 Disease denotes HIV encephalitis http://purl.obolibrary.org/obo/MONDO_0020689
T36 17417-17429 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T37 17431-17435 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T38 17437-17450 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T39 17441-17450 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 17997-18001 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T41 18148-18150 Disease denotes R2 http://purl.obolibrary.org/obo/MONDO_0019903
T42 18373-18377 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T43 18638-18654 Disease denotes hypersensitivity http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271
T45 20235-20239 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T46 20268-20272 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T47 20706-20710 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T48 20772-20776 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T49 20966-20984 Disease denotes Sensory Neuropathy http://purl.obolibrary.org/obo/MONDO_0002321
T50 20974-20984 Disease denotes Neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T51 21002-21020 Disease denotes sensory neuropathy http://purl.obolibrary.org/obo/MONDO_0002321
T52 21010-21020 Disease denotes neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T53 21698-21701 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T54 21775-21778 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T55 21969-21972 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T56 22146-22149 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T57 22272-22275 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T58 22444-22447 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T59 22553-22559 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T60 22890-22893 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T61 23002-23005 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T62 23413-23416 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T63 23504-23517 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T64 23896-23899 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T65 23981-23998 Disease denotes Neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T66 24483-24502 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T67 24493-24502 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T68 24953-24970 Disease denotes Neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T69 25278-25288 Disease denotes Neuropathy http://purl.obolibrary.org/obo/MONDO_0005244
T70 26489-26499 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T71 26589-26598 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72 26603-26613 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T73 27476-27480 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T74 27482-27498 Disease denotes HIV encephalitis http://purl.obolibrary.org/obo/MONDO_0020689
T75 27486-27498 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T76 29088-29097 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77 31220-31222 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T78 31693-31696 Disease denotes NPC http://purl.obolibrary.org/obo/MONDO_0011775|http://purl.obolibrary.org/obo/MONDO_0015459|http://purl.obolibrary.org/obo/MONDO_0018982
T81 32110-32112 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T82 32188-32201 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T83 32192-32201 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 32506-32508 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T85 32754-32756 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T86 33660-33671 Disease denotes astrocytoma http://purl.obolibrary.org/obo/MONDO_0019781|http://purl.obolibrary.org/obo/MONDO_0021636
T88 34064-34076 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T89 34313-34315 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T90 34527-34529 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T91 34610-34612 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T92 34736-34738 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T93 34807-34816 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T94 35385-35398 Disease denotes Neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T95 35612-35614 Disease denotes BV http://purl.obolibrary.org/obo/MONDO_0005316
T96 36196-36209 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T97 36254-36260 Disease denotes Injury http://purl.obolibrary.org/obo/MONDO_0021178
T98 36711-36724 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T99 37302-37315 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T100 37945-37948 Disease denotes FTC http://purl.obolibrary.org/obo/MONDO_0008566
T101 38326-38328 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T102 38436-38438 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T103 38634-38636 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T104 38745-38748 Disease denotes NPC http://purl.obolibrary.org/obo/MONDO_0011775|http://purl.obolibrary.org/obo/MONDO_0015459|http://purl.obolibrary.org/obo/MONDO_0018982
T107 38768-38770 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T108 38797-38800 Disease denotes NPC http://purl.obolibrary.org/obo/MONDO_0011775|http://purl.obolibrary.org/obo/MONDO_0015459|http://purl.obolibrary.org/obo/MONDO_0018982
T111 38944-38946 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T112 38957-38960 Disease denotes ADA http://purl.obolibrary.org/obo/MONDO_0007064
T113 39065-39067 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T114 39098-39111 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T115 39240-39242 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T116 39321-39334 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T117 39383-39396 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T118 39908-39911 Disease denotes FTC http://purl.obolibrary.org/obo/MONDO_0008566
T119 41165-41174 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T120 41355-41365 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T121 43182-43195 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T122 44270-44282 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T123 44912-44924 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T124 46411-46423 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T125 46609-46621 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T126 47621-47624 Disease denotes RNS http://purl.obolibrary.org/obo/MONDO_0009821|http://purl.obolibrary.org/obo/MONDO_0019105
T128 48350-48353 Disease denotes RNS http://purl.obolibrary.org/obo/MONDO_0009821|http://purl.obolibrary.org/obo/MONDO_0019105
T130 48429-48432 Disease denotes UPS http://purl.obolibrary.org/obo/MONDO_0002142
T131 48632-48635 Disease denotes UPS http://purl.obolibrary.org/obo/MONDO_0002142
T132 48872-48875 Disease denotes UPS http://purl.obolibrary.org/obo/MONDO_0002142
T133 49354-49366 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T134 49494-49507 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T135 49626-49632 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T136 51590-51596 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T137 52532-52538 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T138 52770-52776 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T139 59776-59793 Disease denotes neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T140 60609-60619 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T141 61079-61082 Disease denotes MDM http://purl.obolibrary.org/obo/MONDO_0009552
T142 61378-61391 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T143 61382-61391 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T144 62255-62268 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T145 62262-62268 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T146 63117-63127 Disease denotes depression http://purl.obolibrary.org/obo/MONDO_0002050
T147 63189-63205 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T148 63214-63217 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T149 63351-63357 Disease denotes Injury http://purl.obolibrary.org/obo/MONDO_0021178
T150 63526-63532 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T151 63797-63801 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T152 63933-63942 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T153 64039-64052 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T154 64043-64052 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T155 65155-65167 Disease denotes Opioid abuse http://purl.obolibrary.org/obo/MONDO_0001225
T156 65429-65446 Disease denotes opiate dependence http://purl.obolibrary.org/obo/MONDO_0005530
T157 65640-65647 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T158 66339-66348 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T159 66615-66618 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T160 66760-66763 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T161 67827-67840 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T162 67831-67840 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T163 67949-67958 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T164 68515-68517 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T165 68627-68636 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T166 71872-71881 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T167 71887-71889 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T168 72281-72283 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T169 72291-72304 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T170 72295-72304 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T171 72690-72692 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T172 74224-74255 Disease denotes severe combined immunodeficient http://purl.obolibrary.org/obo/MONDO_0015974
T173 74262-74266 Disease denotes SCID http://purl.obolibrary.org/obo/MONDO_0015974
T174 76154-76156 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T175 76366-76368 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T176 76405-76413 Disease denotes hepatoma http://purl.obolibrary.org/obo/MONDO_0007256
T177 76636-76638 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T178 76643-76645 Disease denotes R4 http://purl.obolibrary.org/obo/MONDO_0015439
T179 77289-77298 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T180 77309-77311 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T181 77415-77424 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T182 79318-79333 Disease denotes drug dependence http://purl.obolibrary.org/obo/MONDO_0005303
T183 79827-79836 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T184 80550-80554 Disease denotes HIVE http://purl.obolibrary.org/obo/MONDO_0020689
T185 80697-80710 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T186 80701-80710 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T187 82018-82020 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T188 85452-85461 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T189 86257-86266 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T190 86316-86318 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T191 86340-86342 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T192 86373-86375 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T193 86409-86411 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T194 86437-86439 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T195 86856-86869 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T196 86998-87011 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T197 87254-87267 Disease denotes neurotoxicity http://purl.obolibrary.org/obo/MONDO_0005527
T198 92422-92447 Disease denotes neurodegenerative disease http://purl.obolibrary.org/obo/MONDO_0005559
T199 93808-93827 Disease denotes neurologic diseases http://purl.obolibrary.org/obo/MONDO_0005071
T200 94344-94357 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T201 94348-94357 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T202 94781-94798 Disease denotes neuroinflammation http://purl.obolibrary.org/obo/MONDO_0004466
T203 95131-95143 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T204 95159-95177 Disease denotes multiple sclerosis http://purl.obolibrary.org/obo/MONDO_0005301
T205 97470-97479 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T206 98230-98248 Disease denotes immune suppression http://purl.obolibrary.org/obo/MONDO_0007816
T207 98446-98459 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T208 98450-98459 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T209 100118-100130 Disease denotes opioid abuse http://purl.obolibrary.org/obo/MONDO_0001225
T210 109644-109653 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T211 111231-111234 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T212 111389-111392 Disease denotes SIV http://purl.obolibrary.org/obo/MONDO_0010029
T213 111393-111402 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T214 112535-112538 Disease denotes R21 http://purl.obolibrary.org/obo/MONDO_0015437

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 98777-98781 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T2 99065-99071 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T3 99122-99130 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T4 99132-99141 http://purl.obolibrary.org/obo/CHEBI_28790 denotes serotonin
T5 99311-99316 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6 99311-99316 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T7 99389-99395 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T8 99437-99445 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T9 99603-99611 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T10 99639-99640 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 99670-99678 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T12 99846-99854 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T13 99948-99956 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T14 99971-99979 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T15 100085-100093 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T16 100382-100390 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T17 100422-100429 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T18 100548-100557 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T19 100616-100620 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20 100723-100731 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T21 100828-100829 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 100856-100865 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T23 100873-100876 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T24 100873-100876 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T25 100963-100972 http://purl.obolibrary.org/obo/CL_0000000 denotes cell-type
T26 101322-101329 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T27 102234-102235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 102273-102274 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 102342-102346 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T30 102391-102394 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T31 102884-102894 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T32 103471-103479 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T33 103638-103639 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 103839-103848 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T35 104120-104130 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T36 104138-104147 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T37 104166-104167 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 104186-104195 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T39 104235-104245 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T40 104363-104375 http://purl.obolibrary.org/obo/OBI_0000245 denotes organization
T41 104384-104393 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T42 104449-104452 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T43 104510-104514 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T44 104543-104546 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T45 104689-104698 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T46 105250-105253 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T47 105250-105253 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T48 105283-105286 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T49 105708-105711 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T50 105708-105711 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T51 105955-105961 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T52 106639-106640 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 107537-107544 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T54 107584-107590 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T55 107682-107685 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T56 107682-107685 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T57 107816-107821 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T58 107816-107821 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T59 107870-107880 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T60 107935-107940 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T61 107935-107940 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T62 108107-108112 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T63 108107-108112 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T64 108137-108138 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 108222-108227 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T66 108222-108227 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T67 108313-108318 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T68 108313-108318 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T69 108431-108436 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T70 108431-108436 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T71 108522-108527 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T72 108522-108527 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T73 108553-108559 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T74 108668-108673 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T75 108668-108673 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T76 108684-108685 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T77 108795-108800 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T78 108795-108800 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T79 108882-108887 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T80 108882-108887 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T81 109320-109325 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T82 109320-109325 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T83 109367-109370 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T84 109367-109370 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T85 109371-109377 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T86 109412-109421 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T87 109462-109467 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T88 109462-109467 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T89 109485-109495 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T90 109749-109759 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T91 109782-109787 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T92 109992-110000 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T93 110027-110028 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 110110-110120 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T95 110156-110157 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 110207-110217 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T97 110373-110382 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T98 110529-110534 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T99 110535-110545 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T100 110547-110556 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T101 110695-110700 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T102 110695-110700 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T103 110701-110711 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T104 110783-110792 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T105 110993-111003 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T106 111158-111159 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T107 111355-111360 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T108 111513-111514 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 111558-111561 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T110 111708-111715 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T111 112296-112305 http://purl.obolibrary.org/obo/OBI_0000245 denotes organized
T9974 207-212 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T45969 230-235 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T24986 261-283 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T38936 261-283 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T51456 261-283 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T39921 285-288 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T78273 285-288 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T61752 285-288 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T57883 853-857 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T35359 975-976 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T81874 977-982 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T47640 1549-1554 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T18975 1549-1554 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T73965 1555-1560 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T21933 1555-1560 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T54654 1694-1702 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T9825 1769-1774 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T35601 1769-1774 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T50159 1892-1897 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T45065 1892-1897 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T38360 1999-2002 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T32967 2270-2271 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1467 2670-2671 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26888 2710-2714 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T527 2777-2780 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T63036 2858-2861 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T6940 2979-2980 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67342 3044-3049 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T90565 3125-3130 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T67865 3148-3153 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T82806 3354-3355 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91511 3470-3471 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54607 3744-3750 http://purl.obolibrary.org/obo/CLO_0009882 denotes Becker
T85246 4125-4131 http://purl.obolibrary.org/obo/CLO_0009882 denotes Becker
T25029 4313-4316 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6401 4545-4548 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T10276 4821-4824 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T87813 5112-5115 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T15123 5189-5192 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T56574 5676-5679 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T16931 5687-5688 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46447 5791-5813 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T4426 5791-5813 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T16238 5791-5813 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T71114 5815-5818 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T75797 5815-5818 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T24892 5815-5818 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T31624 6344-6348 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T67954 6814-6819 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T23415 6814-6819 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T85547 7053-7058 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T35015 7053-7058 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T89758 7532-7542 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T74178 8023-8027 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T28968 8070-8071 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T341 8299-8309 http://purl.obolibrary.org/obo/UBERON_0000119 denotes cell layer
T98752 8569-8574 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T24863 8569-8574 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T98993 8732-8738 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T84522 8792-8796 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T33224 9121-9124 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T8189 9673-9675 http://purl.obolibrary.org/obo/CLO_0050160 denotes T2
T95684 9765-9768 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T53516 9765-9768 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T23483 9765-9768 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T99017 9964-9966 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T26720 9964-9966 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T98729 10009-10010 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8555 10190-10193 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T18804 10190-10193 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T44390 10190-10193 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T44837 10260-10269 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T4348 10403-10412 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocyte
T86955 10840-10850 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T88392 10855-10864 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T3020 11051-11055 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T61584 11266-11276 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T24766 11469-11470 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10043 11633-11634 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92174 11726-11727 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T57736 12013-12022 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T75304 12029-12030 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58860 12252-12253 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58219 12419-12420 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41182 12525-12528 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T77891 12525-12528 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T63860 12525-12528 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T93692 13193-13198 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T68688 13922-13932 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T79627 13972-13977 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T33018 14226-14235 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T73862 14648-14657 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T23496 14679-14683 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T37874 14997-15001 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T54483 15320-15323 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T12730 15332-15333 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73274 15494-15497 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T70101 15525-15526 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22068 15631-15632 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T80547 16182-16186 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T72479 16201-16205 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T44553 16405-16408 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T1442 16519-16522 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T9138 16519-16522 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T36989 16519-16522 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T90278 16849-16852 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T48453 16849-16852 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T23922 16849-16852 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T93134 17022-17027 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T83255 17207-17212 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T23448 17310-17315 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T112 17372-17375 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T113 17383-17388 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T114 17451-17454 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T115 17451-17454 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T116 17451-17454 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T117 17512-17517 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T118 17530-17535 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T119 17548-17553 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T120 17548-17553 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T121 17584-17594 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T122 17617-17621 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T123 17633-17643 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T124 17669-17674 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T125 17687-17692 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T126 17687-17692 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T127 17790-17800 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T128 17801-17806 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T129 17868-17872 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T130 17873-17878 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T131 17891-17896 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T132 17891-17896 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T133 17951-17953 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T134 17974-17978 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T135 18033-18037 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T136 18038-18043 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T137 18056-18061 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T138 18056-18061 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T139 18081-18087 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T140 18175-18177 http://purl.obolibrary.org/obo/CLO_0008697 denotes R1
T141 18175-18177 http://purl.obolibrary.org/obo/CLO_0052381 denotes R1
T142 18182-18188 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T143 18189-18194 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T144 18277-18282 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T145 18277-18282 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T146 18333-18336 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T147 18337-18342 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T148 18343-18348 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T149 18470-18475 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T150 18488-18493 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T151 18488-18493 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T152 18711-18716 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T153 18853-18858 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T154 18860-18866 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T155 18953-18958 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T156 19076-19081 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T157 19172-19177 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T158 19332-19337 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T159 19352-19356 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T160 19561-19566 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T161 19582-19586 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T162 19744-19749 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T163 19831-19836 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T164 19924-19929 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T165 19997-20004 http://www.ebi.ac.uk/efo/EFO_0000881 denotes Digital
T166 20020-20024 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T167 20050-20055 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T168 20151-20156 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T169 20174-20178 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T170 20330-20335 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T171 20349-20354 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T172 20349-20354 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T173 20525-20530 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T174 20631-20636 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T175 20756-20759 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T176 20777-20782 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T177 20795-20800 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T178 20795-20800 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T179 20935-20940 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T180 21066-21071 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T181 21130-21136 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T182 21157-21162 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T183 21157-21162 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T184 21315-21330 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T185 21404-21407 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T186 21413-21416 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T187 21418-21425 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T188 21479-21484 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T189 21479-21484 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T190 21485-21500 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T191 21663-21666 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T192 21702-21717 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T193 21779-21783 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T194 21917-21920 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T195 22017-22032 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T196 22096-22099 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T197 22215-22218 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T198 22737-22742 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T199 22865-22871 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T200 22966-22967 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T201 22981-22983 http://purl.obolibrary.org/obo/CLO_0001869 denotes BB
T202 23015-23016 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T203 23066-23076 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T204 23077-23092 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T205 23117-23127 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T206 23232-23237 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T207 23239-23243 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T208 23239-23243 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T209 23248-23254 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T210 23472-23487 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T211 23489-23494 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T212 23496-23503 http://purl.obolibrary.org/obo/CLO_0009015 denotes SH-SY5Y
T213 23496-23503 http://purl.obolibrary.org/obo/CLO_0051795 denotes SH-SY5Y
T214 23496-23503 http://purl.obolibrary.org/obo/CLO_0052135 denotes SH-SY5Y
T215 23496-23503 http://purl.obolibrary.org/obo/CLO_0052139 denotes SH-SY5Y
T216 23496-23503 http://purl.obolibrary.org/obo/CLO_0052141 denotes SH-SY5Y
T217 23518-23532 http://purl.obolibrary.org/obo/CL_0001034 denotes cells in vitro
T218 23711-23726 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T219 23751-23754 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T220 23751-23754 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T221 23751-23754 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T222 23945-23960 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T223 24065-24074 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T224 24075-24080 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T225 24090-24095 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T226 24090-24095 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T227 24212-24222 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T228 24268-24277 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T229 24341-24346 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T230 24529-24533 http://purl.obolibrary.org/obo/CLO_0050768 denotes TLR2
T231 24546-24551 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T232 24553-24557 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T233 24553-24557 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T234 24568-24577 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T235 24676-24681 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T236 24676-24681 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T237 24913-24918 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T238 24928-24933 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T239 24928-24933 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T240 25237-25242 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T241 25252-25257 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T242 25252-25257 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T243 25272-25276 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T244 25416-25421 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T245 25416-25421 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T246 25447-25451 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T247 25564-25568 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T248 25576-25581 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T249 25591-25596 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T250 25591-25596 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T251 25756-25761 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T252 25771-25776 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T253 25771-25776 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T254 25901-25909 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T255 25932-25937 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T256 25939-25944 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T257 25954-25961 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T258 26084-26099 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes Rhesus macaques
T259 26194-26199 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T260 26209-26216 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T261 26325-26330 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T262 26325-26330 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T263 26331-26336 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T264 26331-26336 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T265 26345-26350 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T266 26359-26366 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T267 26397-26401 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T268 26419-26422 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T269 26419-26422 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T270 26419-26422 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T271 26459-26468 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T272 26473-26480 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T273 26509-26512 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T274 26509-26512 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T275 26509-26512 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T276 26531-26537 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T277 26578-26583 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T278 26585-26588 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T279 26585-26588 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T280 26585-26588 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T281 26616-26621 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T282 26616-26621 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T283 26781-26790 http://purl.obolibrary.org/obo/UBERON_0000955 denotes in brains
T284 26781-26790 http://www.ebi.ac.uk/efo/EFO_0000302 denotes in brains
T285 26811-26818 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T286 26819-26824 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T287 26833-26840 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T288 26952-26960 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T289 26961-26966 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T290 26976-26981 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T291 26976-26981 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T292 27018-27019 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T293 27045-27046 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T294 27084-27085 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T295 27161-27166 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T296 27161-27166 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T297 27167-27172 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T298 27167-27172 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T299 27196-27197 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T300 27265-27268 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T301 27265-27268 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T302 27265-27268 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T303 27270-27292 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T304 27270-27292 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T305 27270-27292 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T306 27438-27446 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T307 27559-27560 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T308 27950-27956 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T309 27993-27994 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T310 28019-28020 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T311 28141-28142 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T312 28231-28234 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T313 28231-28234 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T314 28231-28234 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T315 28410-28444 http://purl.obolibrary.org/obo/CL_0000842 denotes peripheral blood mononuclear cells
T316 28410-28444 http://purl.obolibrary.org/obo/CL_2000001 denotes peripheral blood mononuclear cells
T317 28485-28494 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T318 28524-28546 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T319 28524-28546 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T320 28524-28546 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T321 28604-28629 http://purl.obolibrary.org/obo/UBERON_0000010 denotes peripheral nervous system
T322 28604-28629 http://www.ebi.ac.uk/efo/EFO_0000891 denotes peripheral nervous system
T323 28719-28720 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T324 29053-29056 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T325 29053-29056 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T326 29053-29056 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T327 29111-29112 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 29231-29235 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T329 29547-29550 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T330 29547-29550 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T331 29547-29550 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T332 29551-29561 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T333 29597-29606 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T334 29771-29780 http://purl.obolibrary.org/obo/CL_0000129 denotes Microglia
T335 30017-30023 http://purl.obolibrary.org/obo/CLO_0007900 denotes Murphy
T336 30281-30291 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T337 30296-30301 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T338 30296-30301 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T339 30395-30399 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T340 30402-30403 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T78283 30466-30469 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T342 30466-30469 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T343 30466-30469 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T344 30470-30480 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T345 30808-30813 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T346 30827-30832 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T347 30847-30858 http://purl.obolibrary.org/obo/CL_0000559 denotes promonocyte
T348 31011-31016 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T349 31161-31166 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T350 31204-31208 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T351 31326-31336 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T352 31356-31361 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T353 31531-31550 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation & ↑ cell
T354 31618-31623 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T355 31788-31797 http://purl.obolibrary.org/obo/CL_0000127 denotes Astrocyte
T356 31823-31828 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T357 31965-31975 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T358 32012-32017 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T359 32056-32060 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T360 32224-32233 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T361 32316-32319 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T362 32335-32340 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T363 32341-32346 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T364 32356-32366 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T365 32371-32380 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T366 32386-32390 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T367 32386-32390 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T368 32386-32390 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T369 32391-32396 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T370 32669-32674 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T371 32718-32728 http://purl.obolibrary.org/obo/CL_0000127 denotes Astrocytes
T372 32791-32796 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T373 32806-32816 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T374 32920-32924 http://purl.obolibrary.org/obo/CLO_0050768 denotes TLR2
T375 32992-32997 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T376 33007-33017 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T377 33108-33113 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T378 33123-33133 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T379 33219-33224 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T380 33234-33244 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T381 33334-33335 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T382 33412-33417 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T383 33427-33437 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T384 33552-33553 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T385 33554-33559 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T386 33569-33579 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T387 33602-33603 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T388 33642-33646 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T389 33653-33658 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T390 33676-33685 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T391 33695-33705 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T392 33840-33845 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T393 33855-33865 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T394 34002-34007 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T395 34016-34021 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T396 34016-34021 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T397 34022-34031 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T398 34033-34040 http://purl.obolibrary.org/obo/CLO_0009059 denotes SK-N-SH
T399 34033-34040 http://purl.obolibrary.org/obo/CLO_0050268 denotes SK-N-SH
T400 34033-34040 http://purl.obolibrary.org/obo/CLO_0052143 denotes SK-N-SH
T401 34033-34040 http://purl.obolibrary.org/obo/CLO_0052144 denotes SK-N-SH
T402 34033-34040 http://purl.obolibrary.org/obo/CLO_0052145 denotes SK-N-SH
T403 34142-34151 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T404 34211-34221 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T405 34222-34223 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T406 34224-34229 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T407 34231-34236 http://purl.obolibrary.org/obo/CLO_0009464 denotes U87MG
T408 34247-34257 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T409 34277-34286 http://purl.obolibrary.org/obo/CL_0000129 denotes Microglia
T410 34469-34474 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T411 34484-34493 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T412 34553-34558 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T413 34568-34577 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T414 34679-34684 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T415 34694-34703 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T416 34732-34734 http://purl.obolibrary.org/obo/CLO_0003358 denotes FL
T417 34844-34849 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T418 34857-34866 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T419 35034-35039 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T420 35047-35052 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T421 35047-35052 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T422 35053-35062 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T423 35220-35225 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T424 35233-35238 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T425 35233-35238 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T426 35239-35248 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T427 35428-35437 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T428 35438-35443 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T429 35451-35460 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T430 35472-35477 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T431 35605-35610 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T432 35612-35616 http://purl.obolibrary.org/obo/CLO_0052671 denotes BV-2
T433 35629-35638 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T434 35665-35674 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T435 35732-35737 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T436 35754-35763 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T437 35893-35898 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T438 35915-35924 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T439 36019-36021 http://purl.obolibrary.org/obo/CLO_0009645 denotes xc
T440 36019-36021 http://purl.obolibrary.org/obo/CLO_0050824 denotes xc
T441 36072-36077 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T442 36087-36096 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T443 36173-36178 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T444 36188-36195 http://purl.obolibrary.org/obo/CLO_0009015 denotes SH-SY5Y
T445 36188-36195 http://purl.obolibrary.org/obo/CLO_0051795 denotes SH-SY5Y
T446 36188-36195 http://purl.obolibrary.org/obo/CLO_0052135 denotes SH-SY5Y
T447 36188-36195 http://purl.obolibrary.org/obo/CLO_0052139 denotes SH-SY5Y
T448 36188-36195 http://purl.obolibrary.org/obo/CLO_0052141 denotes SH-SY5Y
T449 36210-36215 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T450 36368-36373 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T451 36434-36442 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T452 36602-36607 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T453 36627-36632 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T454 36665-36670 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T455 36703-36710 http://purl.obolibrary.org/obo/CLO_0009015 denotes SH-SY5Y
T456 36703-36710 http://purl.obolibrary.org/obo/CLO_0051795 denotes SH-SY5Y
T457 36703-36710 http://purl.obolibrary.org/obo/CLO_0052135 denotes SH-SY5Y
T458 36703-36710 http://purl.obolibrary.org/obo/CLO_0052139 denotes SH-SY5Y
T459 36703-36710 http://purl.obolibrary.org/obo/CLO_0052141 denotes SH-SY5Y
T460 36725-36730 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T461 36949-36954 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T462 37057-37067 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T463 37113-37118 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T464 37278-37279 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T465 37317-37322 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T466 37599-37609 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T467 37610-37615 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T468 37658-37663 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T469 37658-37663 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T470 37664-37669 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T471 37664-37669 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T472 37772-37776 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T473 37810-37818 http://purl.obolibrary.org/obo/CL_0000576 denotes Monocyte
T474 37844-37849 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T475 37883-37893 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T476 37999-38004 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T477 38014-38024 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T478 38104-38105 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T479 38178-38188 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T480 38207-38216 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T481 38231-38236 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T482 38482-38487 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T483 38845-38850 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T484 38860-38865 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T485 38867-38872 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T486 39123-39128 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T487 39444-39454 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T488 39459-39468 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T489 39508-39509 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T490 39535-39536 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T491 39618-39623 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T492 39618-39623 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T493 39633-39650 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T494 40012-40022 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctional
T495 40053-40055 http://purl.obolibrary.org/obo/CLO_0052906 denotes Cl
T496 40150-40158 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T497 40292-40297 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T498 40420-40457 http://purl.obolibrary.org/obo/PR_000006611 denotes terminal deoxynucleotidyl transferase
T499 40472-40480 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeling
T500 40559-40562 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T501 40559-40562 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T502 40559-40562 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T503 40776-40785 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T504 40815-40837 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T505 40815-40837 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T506 40815-40837 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T507 40895-40920 http://purl.obolibrary.org/obo/UBERON_0000010 denotes peripheral nervous system
T508 40895-40920 http://www.ebi.ac.uk/efo/EFO_0000891 denotes peripheral nervous system
T509 41010-41011 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T510 41300-41303 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T511 41300-41303 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T512 41300-41303 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T513 41366-41372 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T514 41419-41424 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T515 41431-41441 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T516 41523-41525 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T517 41523-41525 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T518 41550-41552 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T519 41550-41552 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T520 41616-41626 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T521 41643-41646 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T522 41643-41646 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T523 41643-41646 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T524 41758-41761 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T525 41893-41895 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T526 41893-41895 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T16796 41943-41945 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T528 41943-41945 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T529 42049-42059 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T530 42302-42311 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T531 42491-42497 http://purl.obolibrary.org/obo/CLO_0007900 denotes Murphy
T532 42543-42553 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T533 42558-42567 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T534 42901-42902 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T535 42980-42984 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T536 43032-43040 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T537 43377-43386 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T538 43515-43525 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T539 43923-43931 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T540 44229-44230 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T541 44372-44382 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T542 44470-44480 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T543 44496-44505 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T544 44744-44745 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T545 44833-44843 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T546 44908-44911 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T547 44908-44911 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T548 44908-44911 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T549 45052-45061 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T550 45153-45163 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T551 45221-45222 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T552 45223-45224 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T553 45320-45321 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T554 45322-45323 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T555 45455-45460 http://purl.obolibrary.org/obo/CLO_0002980 denotes F4/80
T556 45474-45483 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T557 45742-45752 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T558 45772-45781 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T559 45782-45789 http://purl.obolibrary.org/obo/CLO_0003797 denotes (h) [*p
T560 45782-45789 http://purl.obolibrary.org/obo/PR_000008725 denotes (h) [*p
T561 45782-45789 http://purl.obolibrary.org/obo/UBERON_0000007 denotes (h) [*p
T562 46071-46080 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T563 46241-46251 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T564 46407-46410 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T565 46407-46410 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T566 46407-46410 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T567 46515-46525 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T568 46543-46553 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T569 46573-46582 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T570 46881-46890 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T571 47149-47153 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T572 47157-47158 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T573 47344-47353 http://purl.obolibrary.org/obo/CL_0000129 denotes Microglia
T574 47364-47374 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T575 47407-47416 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T576 47779-47788 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T577 47888-47890 http://purl.obolibrary.org/obo/CLO_0009645 denotes xc
T578 47888-47890 http://purl.obolibrary.org/obo/CLO_0050824 denotes xc
T579 48248-48256 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T580 48310-48319 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T581 48606-48614 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T582 48677-48686 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T583 48692-48693 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T584 48916-48917 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T585 48959-48960 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T586 49020-49029 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T587 49105-49108 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T588 49105-49108 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T589 49105-49108 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T590 49309-49318 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T591 49892-49893 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T592 50027-50028 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T593 50061-50069 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T594 50163-50164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T595 50573-50583 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T596 50982-50983 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T597 51232-51233 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T598 51929-51937 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T599 51943-51944 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T600 52437-52438 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T601 52439-52440 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T602 52817-52826 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T603 52926-52936 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T604 53164-53174 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T605 53202-53212 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T606 53282-53292 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T607 53402-53407 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T608 53402-53407 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T609 53408-53413 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T610 53408-53413 http://www.ebi.ac.uk/efo/EFO_0000302 denotes Brain
T611 53598-53603 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T612 53598-53603 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T613 53604-53609 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T614 53604-53609 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T615 53681-53684 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T616 53681-53684 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T617 53681-53684 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T618 53783-53786 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T619 53783-53786 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T620 53783-53786 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T621 53864-53872 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T622 54318-54335 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T623 54514-54522 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T624 55488-55489 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T625 55498-55503 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T626 55504-55509 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T627 55504-55509 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T628 55524-55540 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T629 55552-55561 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocyte
T630 55724-55728 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T631 56108-56113 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T632 56270-56271 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T633 56339-56346 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T634 56386-56391 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T635 56386-56391 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T636 56497-56502 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T637 56497-56502 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T638 56507-56508 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T639 56689-56690 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T640 56889-56890 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T641 56918-56921 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T642 56918-56921 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T643 56918-56921 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T644 57048-57053 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T645 57048-57053 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T646 57135-57140 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T647 57135-57140 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T648 57199-57200 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T649 57276-57281 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T650 57276-57281 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T651 57358-57363 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T652 57364-57370 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brains
T653 57364-57370 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brains
T654 57444-57445 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T655 57458-57459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T656 57790-57791 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T657 58270-58274 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T658 58719-58720 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T659 58738-58750 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessel
T660 58738-58750 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessel
T661 59007-59013 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T662 59288-59294 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T663 59413-59414 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T664 59596-59604 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T665 59641-59646 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T666 59641-59646 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T667 59710-59715 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T668 59710-59715 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T669 59875-59883 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T670 59915-59918 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T671 59915-59918 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T672 59915-59918 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T673 60220-60230 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T674 60459-60460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T675 60481-60489 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T676 60694-60698 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T677 60720-60725 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T678 60720-60725 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T679 60741-60745 http://purl.obolibrary.org/obo/CLO_0050768 denotes TLR2
T680 60867-60872 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T681 60867-60872 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T682 60938-60946 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T683 61050-61055 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T684 61050-61055 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T685 61070-61078 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T686 61120-61125 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T687 61120-61125 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T688 61197-61200 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T689 61197-61200 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T690 61197-61200 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T691 61265-61270 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T692 61265-61270 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T693 61403-61408 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T694 61403-61408 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T695 61478-61483 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T696 61478-61483 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T697 61484-61489 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T698 61484-61489 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T699 61613-61622 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junctions
T700 61751-61756 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T701 61751-61756 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T702 61781-61782 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T703 61892-61897 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T704 61892-61897 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T705 61951-61956 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T706 61951-61956 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T707 62046-62047 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T708 62071-62079 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T709 62146-62151 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T710 62146-62151 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T711 62255-62261 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T712 62324-62329 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T713 62324-62329 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T714 63206-63211 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T715 63229-63244 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes rhesus macaques
T716 63285-63294 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T717 63658-63664 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T718 63755-63758 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T719 63787-63793 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brains
T720 63787-63793 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brains
T721 63812-63815 http://purl.obolibrary.org/obo/CLO_0002742 denotes Del
T722 63910-63913 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T723 64072-64073 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T724 64271-64276 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T725 64726-64734 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T726 65032-65041 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T727 65344-65346 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T728 65344-65346 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T729 65461-65465 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T730 65686-65690 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T731 66158-66168 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T732 66628-66643 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes rhesus macaques
T733 67124-67134 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T734 67388-67398 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T735 67657-67667 http://purl.obolibrary.org/obo/CL_0000031 denotes neuroblast
T736 67668-67678 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T737 67810-67814 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T738 67930-67931 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T739 67942-67948 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T740 67971-67972 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T741 68273-68278 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T742 68334-68348 http://purl.obolibrary.org/obo/CL_0000031 denotes neuroblasts at
T743 68464-68469 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T744 68488-68493 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T745 68765-68782 http://purl.obolibrary.org/obo/CL_0000047 denotes neural stem cells
T746 68889-68893 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T747 68895-68898 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T748 69176-69186 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T749 69368-69370 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T750 69368-69370 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T751 69484-69490 http://purl.obolibrary.org/obo/CLO_0001020 denotes a cell
T752 69516-69526 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T753 69532-69541 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T754 69606-69615 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T755 69650-69652 http://purl.obolibrary.org/obo/CLO_0001869 denotes BB
T756 69812-69815 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T757 69812-69815 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T758 69812-69815 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T759 70124-70128 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T760 70338-70342 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T761 70358-70362 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T762 70728-70729 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T763 70744-70754 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T764 70790-70800 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T765 70964-70975 http://purl.obolibrary.org/obo/UBERON_0002240 denotes spinal cord
T766 71152-71156 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T767 71204-71205 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T768 71306-71311 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T769 71417-71419 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T770 71823-71828 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T771 71847-71852 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T772 71993-72003 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T773 72349-72350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T774 72595-72597 http://purl.obolibrary.org/obo/CLO_0001869 denotes BB
T775 72609-72610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T776 72754-72759 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T777 72826-72836 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T778 72841-72844 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T779 72841-72844 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T780 72841-72844 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T781 73002-73003 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T782 73128-73133 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T783 73479-73484 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T784 73600-73601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T785 74027-74028 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T786 74056-74057 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T787 74152-74153 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T788 74292-74293 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T789 74524-74525 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T790 74601-74604 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T791 74730-74731 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T792 74814-74816 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T793 74814-74816 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T794 74977-74985 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T795 75017-75022 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T796 75017-75022 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T797 75189-75191 http://purl.obolibrary.org/obo/CLO_0002860 denotes E2
T798 75212-75214 http://purl.obolibrary.org/obo/CLO_0001562 denotes A2
T799 75227-75237 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T800 75279-75280 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T801 75409-75410 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T802 75686-75687 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T803 75735-75736 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T804 75849-75856 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T805 76291-76295 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T806 76397-76398 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T807 76399-76404 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T808 76423-76432 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T809 76966-76967 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T810 77180-77184 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T811 77250-77254 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T812 77816-77820 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T813 77998-78002 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T814 78113-78122 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes are
T815 78180-78183 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T816 78185-78189 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T817 78529-78538 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T818 78793-78797 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T819 78917-78918 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T820 78956-78958 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T821 79115-79119 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T822 79473-79478 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T823 79570-79575 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T824 79693-79699 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T825 80028-80058 http://purl.obolibrary.org/obo/PR_000030035 denotes G Protein-coupled receptors or
T826 80107-80113 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T827 80114-80122 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T828 80209-80214 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T829 80285-80288 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T830 80285-80288 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T831 80285-80288 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T832 80289-80299 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T833 80477-80482 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T834 80517-80520 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T835 81084-81093 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T836 81319-81329 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T837 81408-81417 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T838 81548-81558 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T839 81803-81804 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T840 81891-81900 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T841 81953-81954 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T842 82154-82157 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T843 82191-82200 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T844 82289-82299 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T845 82303-82304 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T846 82442-82450 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T847 82470-82479 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T848 82649-82652 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T849 82649-82652 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T850 82649-82652 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T851 82653-82656 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T852 82695-82705 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T853 82717-82726 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T854 82754-82764 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T855 82805-82815 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T856 82820-82830 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T857 82970-82974 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T858 83091-83100 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocyte
T859 83244-83253 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T860 83326-83327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T861 83426-83436 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T862 83449-83458 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T863 83496-83505 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T864 83571-83572 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T865 83705-83715 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T866 83724-83733 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T867 83842-83852 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T868 83857-83866 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T869 84046-84056 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T870 84151-84160 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T871 84335-84345 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T872 84376-84385 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T873 84590-84600 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T874 84613-84622 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T875 84742-84752 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T876 84865-84870 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T877 84893-84894 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T878 84935-84939 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T879 84993-84994 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T880 85012-85013 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T881 85044-85045 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T882 85046-85054 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T883 85219-85220 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T884 85350-85351 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T885 85466-85476 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T886 85485-85494 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T887 85517-85518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T888 85586-85594 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T889 85689-85699 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T890 85704-85713 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T891 85827-85837 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T892 85942-85951 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T893 86097-86106 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T894 86247-86249 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T895 86295-86300 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T896 86466-86467 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T897 86468-86469 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T898 86632-86642 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T899 86731-86741 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T900 86766-86767 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T901 86919-86923 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T902 87094-87098 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T903 87146-87150 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T904 87316-87317 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T905 87476-87485 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T906 87498-87502 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T907 87606-87615 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T908 87641-87642 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T909 87734-87747 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate cell
T910 87876-87880 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T911 88220-88224 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T912 88289-88294 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T913 88356-88357 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T914 88600-88601 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T915 88678-88688 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T916 88743-88744 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T917 88756-88757 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T918 88844-88848 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T919 88880-88881 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T920 88882-88883 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T921 89132-89136 http://purl.obolibrary.org/obo/CLO_0001545 denotes a 72
T922 89849-89853 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T923 90277-90286 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T924 90352-90356 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T925 91865-91874 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T926 91932-91933 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T927 92005-92009 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T928 92013-92014 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T929 92015-92016 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T930 92133-92137 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T931 92264-92267 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T932 92483-92487 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T933 92576-92585 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T934 92609-92610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T935 92768-92769 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T936 93034-93042 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T937 93135-93143 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T938 93414-93421 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T939 93433-93438 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T940 93579-93582 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes Pan
T941 93601-93602 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T942 93631-93638 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T943 93708-93711 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T944 93712-93713 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T945 93754-93757 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T946 94247-94248 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T947 94455-94464 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T948 94769-94777 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T949 94887-94888 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T950 95032-95066 http://purl.obolibrary.org/obo/CL_0000842 denotes peripheral blood mononuclear cells
T951 95032-95066 http://purl.obolibrary.org/obo/CL_2000001 denotes peripheral blood mononuclear cells
T952 95234-95247 http://purl.obolibrary.org/obo/PR_000001091 denotes interleukin-1
T953 95363-95373 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T954 95398-95403 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T955 95398-95403 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T956 95509-95518 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T957 95664-95669 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T958 95664-95669 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T959 95883-95890 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T960 95929-95932 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T961 95951-95956 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T962 95982-95988 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T963 96176-96183 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T964 96229-96232 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T965 96229-96232 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T966 96229-96232 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T967 96712-96720 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T968 96744-96745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T969 96746-96751 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T970 96746-96751 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T971 96757-96766 http://purl.obolibrary.org/obo/CL_0000000 denotes cell-type
T972 97054-97057 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T973 97054-97057 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T974 97054-97057 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T975 97113-97114 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T976 97538-97546 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T977 97639-97648 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T978 97729-97730 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T979 98000-98010 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T980 98173-98183 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T981 98502-98505 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T982 98502-98505 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T983 98502-98505 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 1703-1711 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T2 1922-1927 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T3 3076-3080 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T4 3164-3168 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T5 4282-4295 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T6 4788-4797 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T7 4872-4878 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T8 5029-5037 Chemical denotes fentanyl http://purl.obolibrary.org/obo/CHEBI_119915
T9 5136-5144 Chemical denotes fentanyl http://purl.obolibrary.org/obo/CHEBI_119915
T10 5278-5286 Chemical denotes fentanyl http://purl.obolibrary.org/obo/CHEBI_119915
T11 5337-5345 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T13 5423-5428 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T14 5581-5584 Chemical denotes DEA http://purl.obolibrary.org/obo/CHEBI_34478|http://purl.obolibrary.org/obo/CHEBI_85259
T16 5587-5595 Chemical denotes fentanyl http://purl.obolibrary.org/obo/CHEBI_119915
T17 6748-6751 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T18 7428-7430 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T20 7439-7451 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T21 7446-7451 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T23 7546-7550 Chemical denotes heme http://purl.obolibrary.org/obo/CHEBI_26355|http://purl.obolibrary.org/obo/CHEBI_30413
T25 7578-7581 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T27 7592-7599 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T28 7648-7673 Chemical denotes reactive nitrogen species http://purl.obolibrary.org/obo/CHEBI_62764
T29 7657-7665 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T30 7675-7678 Chemical denotes RNS http://purl.obolibrary.org/obo/CHEBI_33697|http://purl.obolibrary.org/obo/CHEBI_62764
T32 7688-7701 Chemical denotes peroxynitrite http://purl.obolibrary.org/obo/CHEBI_25941
T33 7968-7975 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T34 8042-8048 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T35 8322-8329 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T36 8898-8901 Chemical denotes tau http://purl.obolibrary.org/obo/CHEBI_36355
T37 9072-9080 Chemical denotes Glycogen http://purl.obolibrary.org/obo/CHEBI_28087
T38 9633-9639 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T39 9673-9675 Chemical denotes T2 http://purl.obolibrary.org/obo/CHEBI_29298|http://purl.obolibrary.org/obo/CHEBI_75710
T41 9964-9966 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T42 10462-10469 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T43 10495-10503 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T45 10620-10628 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T47 11239-11247 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T49 11495-11502 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T50 12663-12667 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T51 12747-12752 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T52 12897-12902 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T53 13750-13758 Chemical denotes cofactor http://purl.obolibrary.org/obo/CHEBI_23357
T54 14019-14021 Chemical denotes Ho http://purl.obolibrary.org/obo/CHEBI_49648
T55 14476-14479 Chemical denotes Guo http://purl.obolibrary.org/obo/CHEBI_16750
T56 14845-14854 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T57 14866-14874 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T59 14960-14968 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61 15278-15284 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T62 15401-15407 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T63 15947-15952 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T64 17185-17190 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T65 17361-17365 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T66 17470-17474 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T67 17760-17764 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T68 17861-17863 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T69 17940-17949 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T70 18112-18119 Chemical denotes codeine http://purl.obolibrary.org/obo/CHEBI_16714|http://purl.obolibrary.org/obo/CHEBI_57871
T72 18121-18129 Chemical denotes fentanyl http://purl.obolibrary.org/obo/CHEBI_119915
T73 18131-18139 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T75 18237-18243 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T76 18268-18271 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T78 18306-18309 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T81 18570-18577 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T83 18590-18597 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T85 18665-18673 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T86 18775-18781 Chemical denotes Heroin http://purl.obolibrary.org/obo/CHEBI_27808
T87 18789-18796 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T89 18905-18911 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T90 19004-19011 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T92 19024-19031 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T94 19144-19153 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T95 19265-19281 Chemical denotes anticholinergics http://purl.obolibrary.org/obo/CHEBI_48873
T96 19300-19311 Chemical denotes anxiolytics http://purl.obolibrary.org/obo/CHEBI_35474
T97 19316-19331 Chemical denotes anticonvulsants http://purl.obolibrary.org/obo/CHEBI_35623
T98 19398-19405 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T100 19407-19414 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T102 19416-19422 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T103 19549-19556 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T105 19642-19651 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T106 19706-19715 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T107 19822-19826 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T108 19896-19902 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T109 20477-20484 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T111 20486-20493 Chemical denotes alcohol http://purl.obolibrary.org/obo/CHEBI_16236|http://purl.obolibrary.org/obo/CHEBI_30879
T113 21209-21217 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T114 21368-21376 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T115 21602-21610 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T116 21678-21681 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T117 21687-21695 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T119 21853-21861 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T120 22008-22016 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T122 22164-22172 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T124 22290-22298 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T126 22329-22337 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T128 22493-22501 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T130 22606-22614 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T131 22644-22647 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T132 22710-22723 Chemical denotes Sphingomyelin http://purl.obolibrary.org/obo/CHEBI_17636|http://purl.obolibrary.org/obo/CHEBI_62490|http://purl.obolibrary.org/obo/CHEBI_89482|http://purl.obolibrary.org/obo/CHEBI_89483|http://purl.obolibrary.org/obo/CHEBI_89488|http://purl.obolibrary.org/obo/CHEBI_89490|http://purl.obolibrary.org/obo/CHEBI_89491
T139 22728-22736 Chemical denotes Ceramide http://purl.obolibrary.org/obo/CHEBI_17761
T140 22783-22791 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T141 22841-22849 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T143 22873-22876 Chemical denotes Guo http://purl.obolibrary.org/obo/CHEBI_16750
T144 22905-22913 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T145 22981-22983 Chemical denotes BB http://purl.obolibrary.org/obo/CHEBI_53109
T146 22989-22997 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T148 23049-23057 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T150 23178-23186 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T151 23239-23243 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T152 23256-23259 Chemical denotes PFC http://purl.obolibrary.org/obo/CHEBI_134091
T153 23326-23334 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T154 23393-23401 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T155 23428-23435 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T156 23496-23498 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T158 23594-23602 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T159 23755-23766 Chemical denotes metabolites http://purl.obolibrary.org/obo/CHEBI_25212
T160 23783-23791 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T161 23870-23878 Chemical denotes Creatine http://purl.obolibrary.org/obo/CHEBI_16919
T162 23902-23910 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T164 23925-23933 Chemical denotes inositol http://purl.obolibrary.org/obo/CHEBI_24848
T165 24010-24018 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T166 24168-24176 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T167 24301-24309 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T169 24419-24427 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T170 24457-24465 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T171 24513-24515 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T173 24553-24557 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T174 24729-24737 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T175 24751-24759 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T176 24785-24793 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T177 24795-24800 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T178 24818-24821 Chemical denotes GTP http://purl.obolibrary.org/obo/CHEBI_15996|http://purl.obolibrary.org/obo/CHEBI_37565
T180 24861-24864 Chemical denotes PFC http://purl.obolibrary.org/obo/CHEBI_134091
T181 24892-24900 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T183 24972-24980 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T185 25049-25057 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T186 25154-25157 Chemical denotes CPP http://purl.obolibrary.org/obo/CHEBI_34603
T187 25327-25335 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T188 25453-25461 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T189 25491-25499 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T190 25619-25627 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T191 25670-25678 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T192 25829-25838 Chemical denotes Oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T193 26004-26012 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T194 26134-26143 Chemical denotes Oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T195 26258-26266 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T196 26430-26438 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T197 26518-26526 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T199 26569-26577 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T201 26668-26671 Chemical denotes ABC http://purl.obolibrary.org/obo/CHEBI_421707
T202 26672-26675 Chemical denotes 3TC http://purl.obolibrary.org/obo/CHEBI_63577
T203 26676-26684 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T204 26743-26751 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T205 26770-26780 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T206 26794-26802 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T208 26893-26901 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T209 27117-27120 Chemical denotes ABC http://purl.obolibrary.org/obo/CHEBI_421707
T210 27122-27130 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T211 27232-27239 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T212 27294-27297 Chemical denotes CPP http://purl.obolibrary.org/obo/CHEBI_34603
T213 27379-27384 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T214 27404-27407 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T215 27438-27446 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T217 27462-27474 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T218 27551-27558 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T219 27579-27583 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T220 27649-27656 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T222 27673-27681 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T223 27685-27688 Chemical denotes 3TC http://purl.obolibrary.org/obo/CHEBI_63577
T224 27690-27700 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T225 27712-27714 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T226 27747-27749 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T227 27934-27937 Chemical denotes PFC http://purl.obolibrary.org/obo/CHEBI_134091
T228 28026-28029 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T229 28031-28054 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T230 28040-28046 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T231 28153-28163 Chemical denotes zidovudine http://purl.obolibrary.org/obo/CHEBI_10110
T232 29487-29495 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T233 29833-29838 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T234 30262-30266 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T235 30694-30703 Chemical denotes Dynorphin http://purl.obolibrary.org/obo/CHEBI_4727
T236 30706-30713 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T237 30719-30727 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T238 30753-30762 Chemical denotes Dynorphin http://purl.obolibrary.org/obo/CHEBI_4727
T239 30768-30775 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T240 30786-30788 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T242 30800-30807 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T243 30902-30909 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T244 30942-30950 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T245 30954-30962 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T246 30969-30977 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T247 31091-31099 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T248 31227-31235 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T249 31316-31322 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T250 31342-31344 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T252 31480-31488 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T253 31567-31575 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T255 31693-31696 Chemical denotes NPC http://purl.obolibrary.org/obo/CHEBI_80552
T256 31740-31748 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T257 31925-31933 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T258 32117-32125 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T259 32144-32150 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T260 32174-32180 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T261 32240-32248 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T263 32269-32275 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T264 32513-32521 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T265 32561-32569 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T267 32761-32769 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T268 32907-32915 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T269 32941-32949 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T271 32976-32984 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T273 33063-33071 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T274 33091-33093 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T276 33167-33175 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T277 33279-33287 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T278 33300-33302 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T280 33330-33332 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T283 33403-33411 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T285 33470-33477 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T286 33483-33490 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T287 33507-33517 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T288 33521-33528 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T289 33538-33545 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T290 33548-33550 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T293 33607-33615 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T294 33642-33644 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T296 33753-33761 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T297 33799-33802 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T298 33928-33933 Chemical denotes DPDPE http://purl.obolibrary.org/obo/CHEBI_73356
T299 33948-33956 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T300 33962-33970 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T301 34033-34035 Chemical denotes SK http://purl.obolibrary.org/obo/CHEBI_144702
T302 34038-34040 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T304 34121-34129 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T305 34322-34335 Chemical denotes Endomorphin-1 http://purl.obolibrary.org/obo/CHEBI_80156
T306 34338-34351 Chemical denotes Endomorphin-2 http://purl.obolibrary.org/obo/CHEBI_80157
T307 34357-34365 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T308 34423-34436 Chemical denotes Endomorphin-1 http://purl.obolibrary.org/obo/CHEBI_80156
T309 34534-34542 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T310 34619-34626 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T311 34641-34649 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T312 34653-34662 Chemical denotes Dynorphin http://purl.obolibrary.org/obo/CHEBI_4727
T313 34663-34665 Chemical denotes Al http://purl.obolibrary.org/obo/CHEBI_28984
T314 34732-34734 Chemical denotes FL http://purl.obolibrary.org/obo/CHEBI_91150
T315 34828-34830 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T317 34839-34841 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T319 34909-34916 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T320 34922-34930 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T321 34934-34941 Chemical denotes Cocaine http://purl.obolibrary.org/obo/CHEBI_27958
T322 34948-34955 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T323 34978-34989 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T324 34996-35003 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T325 35012-35019 Chemical denotes cocaine http://purl.obolibrary.org/obo/CHEBI_27958|http://purl.obolibrary.org/obo/CHEBI_60056
T327 35144-35151 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T328 35328-35335 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T329 35341-35348 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T330 35373-35380 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T331 35400-35407 Chemical denotes U50,488 http://purl.obolibrary.org/obo/CHEBI_73358
T332 35533-35541 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T333 35582-35584 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T335 35590-35595 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T336 35590-35592 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T337 35686-35694 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T338 35822-35830 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T339 35835-35838 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T340 35840-35842 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T341 35859-35863 Chemical denotes H2O2 http://purl.obolibrary.org/obo/CHEBI_16240
T342 35875-35882 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T343 35955-35964 Chemical denotes Glutamate http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237
T345 35984-35992 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T346 35995-36004 Chemical denotes Glutamate http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237
T348 36023-36030 Chemical denotes cystine http://purl.obolibrary.org/obo/CHEBI_17376
T349 36031-36040 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T351 36147-36155 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T352 36188-36190 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T354 36272-36280 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T355 36299-36301 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T356 36457-36460 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T357 36491-36499 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T358 36552-36560 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T360 36585-36601 Chemical denotes allopregnanolone http://purl.obolibrary.org/obo/CHEBI_50169
T361 36703-36705 Chemical denotes SH http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651
T363 36809-36817 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T364 36851-36859 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T366 37019-37027 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T367 37180-37188 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T368 37274-37276 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T371 37293-37301 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T373 37487-37495 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T374 37520-37528 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T376 37749-37757 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T377 37772-37774 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T379 37953-37961 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T380 38114-38122 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T381 38171-38174 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T382 38222-38230 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T384 38333-38341 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T385 38473-38481 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T387 38656-38664 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T388 38732-38740 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T390 38745-38748 Chemical denotes NPC http://purl.obolibrary.org/obo/CHEBI_80552
T391 38749-38752 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T392 38784-38792 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T394 38797-38800 Chemical denotes NPC http://purl.obolibrary.org/obo/CHEBI_80552
T395 38801-38804 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T396 38836-38844 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T398 38920-38924 Chemical denotes GABA http://purl.obolibrary.org/obo/CHEBI_16865
T399 38957-38960 Chemical denotes ADA http://purl.obolibrary.org/obo/CHEBI_39048
T400 38962-38964 Chemical denotes MN http://purl.obolibrary.org/obo/CHEBI_141442
T401 38989-38997 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T402 39007-39015 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T404 39114-39122 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T406 39249-39257 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T407 39268-39273 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T408 39276-39284 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T409 39337-39345 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T410 39674-39681 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T412 39730-39735 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T413 39755-39758 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T414 39860-39872 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T415 39874-39879 Chemical denotes DPDPE http://purl.obolibrary.org/obo/CHEBI_73356
T416 39913-39926 Chemical denotes emtricitabine http://purl.obolibrary.org/obo/CHEBI_31536
T417 39928-39932 Chemical denotes GABA http://purl.obolibrary.org/obo/CHEBI_16865
T418 39949-39953 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T419 39969-39976 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T421 39993-40001 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T422 40032-40040 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T423 40053-40055 Chemical denotes Cl http://purl.obolibrary.org/obo/CHEBI_23116
T424 40195-40197 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T425 40216-40222 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T426 40321-40324 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T427 40326-40349 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T428 40335-40341 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T429 40402-40411 Chemical denotes tenofovir http://purl.obolibrary.org/obo/CHEBI_134504|http://purl.obolibrary.org/obo/CHEBI_63625|http://purl.obolibrary.org/obo/CHEBI_63716
T432 40458-40462 Chemical denotes dUTP http://purl.obolibrary.org/obo/CHEBI_17625|http://purl.obolibrary.org/obo/CHEBI_61555
T434 40487-40497 Chemical denotes zidovudine http://purl.obolibrary.org/obo/CHEBI_10110
T435 41208-41210 Chemical denotes Ko http://purl.obolibrary.org/obo/CHEBI_59348
T436 41523-41525 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T437 41550-41552 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T438 41893-41895 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T439 41920-41922 Chemical denotes Al http://purl.obolibrary.org/obo/CHEBI_28984
T440 41943-41945 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T441 42033-42040 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T442 42570-42578 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T444 42721-42729 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T446 42863-42871 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T448 43923-43931 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T449 44136-44138 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T451 44561-44569 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T453 44635-44642 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T455 44740-44742 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T458 44773-44780 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T459 44811-44813 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T461 45123-45130 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T462 45401-45409 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T464 45661-45669 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T466 45881-45889 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T468 46103-46111 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T470 47594-47600 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T471 47602-47605 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T472 47611-47619 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T473 47621-47624 Chemical denotes RNS http://purl.obolibrary.org/obo/CHEBI_33697|http://purl.obolibrary.org/obo/CHEBI_62764
T475 47684-47693 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T477 47718-47721 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T479 47805-47814 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T481 47859-47866 Chemical denotes cystine http://purl.obolibrary.org/obo/CHEBI_17376
T482 47867-47876 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T484 48016-48024 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T486 48163-48183 Chemical denotes proteasome inhibitor http://purl.obolibrary.org/obo/CHEBI_52726
T487 48174-48183 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T488 48214-48222 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T490 48282-48284 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T492 48343-48346 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T493 48350-48353 Chemical denotes RNS http://purl.obolibrary.org/obo/CHEBI_33697|http://purl.obolibrary.org/obo/CHEBI_62764
T495 48703-48706 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T496 48762-48770 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T498 48955-48957 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T19918 49539-49547 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T97552 49596-49599 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T32116 49783-49791 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T64562 49954-49956 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T5757 49993-49995 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T9480 50008-50011 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T12334 50219-50227 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T12 50340-50348 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T64066 50391-50394 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T15 50437-50446 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T80163 50514-50522 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T11885 50589-50597 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T19 50639-50641 Chemical denotes Al http://purl.obolibrary.org/obo/CHEBI_28984
T22795 50776-50783 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T56524 50858-50866 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T22 50938-50947 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T54050 50949-50952 Chemical denotes RyR http://purl.obolibrary.org/obo/CHEBI_8925
T24 51041-51050 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T4899 51060-51069 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T26 51074-51082 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T553 51110-51118 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61869 51149-51159 Chemical denotes Nimodipine http://purl.obolibrary.org/obo/CHEBI_7575
T41653 51194-51204 Chemical denotes dantrolene http://purl.obolibrary.org/obo/CHEBI_4317
T31 51273-51282 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T4654 51322-51330 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T47424 51395-51405 Chemical denotes nimodipine http://purl.obolibrary.org/obo/CHEBI_7575
T96207 51407-51417 Chemical denotes dantrolene http://purl.obolibrary.org/obo/CHEBI_4317
T9447 51422-51430 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T14570 51494-51496 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T32988 51498-51500 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T39702 51514-51522 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T69404 51560-51568 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T44 51648-51656 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T46 51719-51724 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T68016 51727-51734 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T48 51737-51743 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T50651 51765-51769 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T52793 51789-51813 Chemical denotes N-methyl-D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_31882
T29928 51791-51797 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T65599 51798-51813 Chemical denotes D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_17364
T6522 51800-51813 Chemical denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T67050 51809-51813 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T85819 51862-51864 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T58 51905-51907 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T79856 51959-51962 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T12888 52012-52014 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T38030 52020-52022 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T87801 52134-52142 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3614 52181-52183 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T82906 52203-52210 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T40213 52267-52276 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T28773 52278-52281 Chemical denotes RyR http://purl.obolibrary.org/obo/CHEBI_8925
T21964 52316-52324 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T33921 52419-52426 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T3867 53118-53133 Chemical denotes methamphetamine http://purl.obolibrary.org/obo/CHEBI_6809
T74 53186-53188 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T37470 53258-53272 Chemical denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T77 53760-53764 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T66460 53816-53824 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T79 53873-53881 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T80 54523-54531 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T11026 54676-54684 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T36538 54727-54735 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T51283 54850-54858 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T26096 54908-54912 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T88 54920-54928 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T30663 54940-54952 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T56470 54985-54993 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T4369 55282-55290 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T5483 55359-55363 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T96748 55374-55382 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T82380 55449-55454 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T97693 55658-55666 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T99 55724-55726 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T101 55802-55810 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T34792 55825-55833 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T104 55944-55952 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T7399 55990-55997 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T80740 56023-56031 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T4988 56182-56190 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T91450 56253-56261 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T19298 56347-56355 Chemical denotes dextrans http://purl.obolibrary.org/obo/CHEBI_52071
T94726 56431-56439 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T77966 56565-56573 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T99250 56641-56645 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T76004 56663-56670 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T118 56710-56718 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T75473 56803-56811 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T72889 56876-56880 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T123 56990-56994 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T54933 57005-57013 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T125 57087-57095 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T127 57252-57258 Chemical denotes tracer http://purl.obolibrary.org/obo/CHEBI_35204
T88715 57388-57396 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T13546 57487-57495 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T66413 57623-57631 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T134 57721-57729 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T136 57779-57787 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T138 57917-57925 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T81225 57942-57950 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T142 57971-57979 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T37279 58239-58252 Chemical denotes Hoechst 33342 http://purl.obolibrary.org/obo/CHEBI_51232
T79767 58275-58281 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T42686 58336-58339 Chemical denotes DIC http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092
T5674 58465-58473 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61069 58917-58922 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T21571 59070-59078 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T2284 59115-59127 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T19714 59136-59144 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T29469 59158-59168 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T20462 59248-59256 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T49655 59372-59380 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T84615 59397-59405 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T26139 59502-59510 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T163 59863-59871 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T58500 60179-60181 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T54779 60208-60216 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T168 60407-60409 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T7125 60430-60438 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T51995 60442-60455 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T172 60635-60643 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T20102 60947-60955 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T81863 60988-60996 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T957 61031-61040 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T7188 61230-61234 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T43871 61245-61253 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T179 61311-61315 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T6618 61834-61846 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T70131 62080-62088 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T182 62280-62287 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37664 62345-62350 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T184 62377-62382 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T31541 63458-63466 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T89434 64227-64233 Chemical denotes toxins http://purl.obolibrary.org/obo/CHEBI_27026
T81711 64545-64550 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T67267 64553-64560 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T72419 64563-64569 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T15567 64591-64595 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T21808 64597-64601 Chemical denotes AMPA http://purl.obolibrary.org/obo/CHEBI_28812
T45000 64603-64627 Chemical denotes N-methyl-D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_31882
T26423 64605-64611 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T62952 64612-64627 Chemical denotes D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_17364
T40246 64614-64627 Chemical denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T198 64623-64627 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T34192 64629-64633 Chemical denotes NMDA http://purl.obolibrary.org/obo/CHEBI_31882|http://purl.obolibrary.org/obo/CHEBI_6121
T34723 65106-65113 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45427 65121-65123 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T57040 65344-65346 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T30274 65476-65485 Chemical denotes oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T80880 65593-65600 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T18397 65660-65667 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T207 65669-65672 Chemical denotes APP http://purl.obolibrary.org/obo/CHEBI_50071
T53241 66669-66677 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T81194 66743-66751 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T45396 67013-67021 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T86193 67181-67189 Chemical denotes naloxone http://purl.obolibrary.org/obo/CHEBI_7459
T71913 67193-67203 Chemical denotes naltrexone http://purl.obolibrary.org/obo/CHEBI_7465
T40596 68068-68071 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T216 68550-68558 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T66011 69368-69370 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T86050 69542-69549 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13220 69650-69652 Chemical denotes BB http://purl.obolibrary.org/obo/CHEBI_53109
T221 70575-70583 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T27653 70613-70621 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T25942 70863-70871 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3391 71000-71008 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T73215 71348-71356 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T48325 72054-72062 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T7311 72178-72188 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T73797 72190-72199 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T91823 72449-72457 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T82694 72595-72597 Chemical denotes BB http://purl.obolibrary.org/obo/CHEBI_53109
T55965 72666-72674 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T58410 74463-74465 Chemical denotes CC http://purl.obolibrary.org/obo/CHEBI_28940
T18687 74814-74816 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T241 74936-74938 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T26700 75175-75191 Chemical denotes prostaglandin E2 http://purl.obolibrary.org/obo/CHEBI_15551|http://purl.obolibrary.org/obo/CHEBI_606564
T67686 75175-75188 Chemical denotes prostaglandin http://purl.obolibrary.org/obo/CHEBI_26333
T87939 75200-75214 Chemical denotes thromboxane A2 http://purl.obolibrary.org/obo/CHEBI_15627|http://purl.obolibrary.org/obo/CHEBI_57445
T85438 75200-75211 Chemical denotes thromboxane http://purl.obolibrary.org/obo/CHEBI_26995
T77864 76092-76100 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T86034 76339-76347 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T48999 76527-76535 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T254 76912-76917 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T32848 77596-77603 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T52018 78082-78086 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T10090 78087-78103 Chemical denotes neurotransmitter http://purl.obolibrary.org/obo/CHEBI_25512
T81858 79161-79165 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T16078 79318-79322 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T80871 79436-79438 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T262 79562-79569 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T37316 79740-79742 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T86315 80030-80037 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T7532 81925-81928 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T266 81945-81950 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T91089 81959-81965 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T50812 82544-82548 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T75121 82970-82972 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T89703 83061-83069 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T17203 83286-83294 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T275 83388-83396 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T17870 83582-83588 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T86945 83603-83612 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T279 83626-83643 Chemical denotes opioid antagonist http://purl.obolibrary.org/obo/CHEBI_60605
T83127 83633-83643 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T281 83645-83655 Chemical denotes naltrexone http://purl.obolibrary.org/obo/CHEBI_7465
T282 83793-83802 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T40802 83872-83880 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T91146 83908-83917 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T3651 83992-84001 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T31316 84073-84081 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T52328 84131-84139 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T291 84436-84444 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T74890 84580-84586 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T5718 84879-84888 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T295 84913-84923 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T15052 84982-84990 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T60468 85109-85116 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T47897 85145-85152 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43994 85189-85195 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T54004 85263-85271 Chemical denotes triazole http://purl.obolibrary.org/obo/CHEBI_38597
T59698 85295-85301 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T303 85361-85366 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T2279 85640-85649 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T26201 85719-85727 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T43395 85773-85782 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T30455 85854-85862 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T96445 85900-85910 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T81282 85971-85979 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T78388 86123-86131 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T13049 86345-86353 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3701 86378-86387 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T318 86389-86392 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T15381 86418-86421 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T24754 86446-86449 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T5763 86452-86462 Chemical denotes naltrexone http://purl.obolibrary.org/obo/CHEBI_7465
T4402 86708-86716 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T35383 86885-86893 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T326 86958-86967 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T78376 87073-87081 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T31893 87356-87364 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T37512 87616-87624 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T67699 87895-87903 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T334 88185-88193 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T85477 88316-88324 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T68690 88517-88525 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T74954 88640-88647 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30670 88900-88908 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T20723 89088-89096 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T15211 89210-89218 Chemical denotes naloxone http://purl.obolibrary.org/obo/CHEBI_7459
T22372 89236-89244 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T96389 89486-89494 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T350 89538-89546 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T37556 89666-89674 Chemical denotes naloxone http://purl.obolibrary.org/obo/CHEBI_7459
T353 89758-89766 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T17637 89982-89984 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T37828 90488-90496 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T7043 90727-90735 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T89089 90951-90959 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T362 91220-91228 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T6684 91336-91344 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61446 91482-91490 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T49943 91592-91600 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T370 92224-92226 Chemical denotes CC http://purl.obolibrary.org/obo/CHEBI_28940
T17030 92351-92359 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3742 93034-93042 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T88543 93089-93094 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T375 93135-93143 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T95008 93414-93421 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T39036 93631-93638 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T378 93640-93650 Chemical denotes nociceptin http://purl.obolibrary.org/obo/CHEBI_80266
T71926 94769-94777 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T56974 94940-94946 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T15446 95250-95252 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T383 95449-95451 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T89997 95804-95814 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T386 95883-95890 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T84666 96176-96183 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T81260 96712-96720 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T389 97136-97140 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T93960 97171-97175 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T19189 97382-97386 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T97969 97489-97492 Chemical denotes HPA http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342
T44514 97538-97546 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T14707 97653-97656 Chemical denotes HPA http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342
T29525 97663-97693 Chemical denotes corticotropin releasing factor http://purl.obolibrary.org/obo/CHEBI_65311
T403 97663-97676 Chemical denotes corticotropin http://purl.obolibrary.org/obo/CHEBI_3892
T13587 97888-97896 Chemical denotes cortisol http://purl.obolibrary.org/obo/CHEBI_17650
T405 97996-97999 Chemical denotes HPA http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342
T18273 98169-98172 Chemical denotes HPA http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342
T40484 98322-98326 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T60355 98327-98336 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T52802 98397-98400 Chemical denotes HPA http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342
T84484 98485-98488 Chemical denotes HPA http://purl.obolibrary.org/obo/CHEBI_29031|http://purl.obolibrary.org/obo/CHEBI_53393|http://purl.obolibrary.org/obo/CHEBI_61431|http://purl.obolibrary.org/obo/CHEBI_64342
T21762 98745-98761 Chemical denotes neurotransmitter http://purl.obolibrary.org/obo/CHEBI_25512
T99163 98896-98902 Chemical denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808
T98849 99043-99060 Chemical denotes neurotransmitters http://purl.obolibrary.org/obo/CHEBI_25512
T88345 99087-99095 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T94074 99122-99130 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T30597 99132-99141 Chemical denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546
T23157 99158-99162 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T53196 99164-99168 Chemical denotes GABA http://purl.obolibrary.org/obo/CHEBI_16865
T93729 99171-99184 Chemical denotes acetylcholine http://purl.obolibrary.org/obo/CHEBI_15355
T22491 99186-99195 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T393 99201-99210 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T66783 99230-99238 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T81259 99437-99445 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T41515 99450-99464 Chemical denotes norepinephrine http://purl.obolibrary.org/obo/CHEBI_18357|http://purl.obolibrary.org/obo/CHEBI_33569
T87195 99552-99558 Chemical denotes Heroin http://purl.obolibrary.org/obo/CHEBI_27808
T2127 99670-99678 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T24088 99846-99854 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T62096 99948-99956 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T44600 99971-99979 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T93735 100085-100093 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T22751 100146-100150 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T14873 100339-100347 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T68259 100349-100358 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T91935 100364-100377 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T40 100540-100547 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T10193 100587-100595 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T91421 100723-100731 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T47036 101210-101218 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T92077 101220-101229 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T1111 101233-101246 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T51088 101676-101680 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T76461 101821-101825 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T96964 102223-102232 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T55392 102245-102252 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T75231 102258-102271 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T1452 102287-102294 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T55931 102307-102317 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T54595 102366-102375 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T51815 102377-102390 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T42352 102896-102903 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T52338 103065-103073 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T42965 103075-103084 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T60 103090-103103 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T67960 103128-103131 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T65348 103203-103211 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T94219 103376-103385 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T10937 103387-103396 Chemical denotes oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T56838 103398-103411 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T19929 103417-103422 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T33804 103604-103609 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T55394 103809-103817 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T93088 104005-104013 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T83042 104251-104259 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T71 104425-104433 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T52460 104577-104585 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T13815 104617-104622 Chemical denotes DAMGO http://purl.obolibrary.org/obo/CHEBI_272
T81707 104626-104634 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T39669 104884-104891 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T86579 104969-104976 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T61999 105005-105012 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77414 105737-105741 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T35911 105742-105746 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T93114 105834-105848 Chemical denotes opioid agonist http://purl.obolibrary.org/obo/CHEBI_60606
T82 105841-105848 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T50219 105850-105863 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T84 105893-105908 Chemical denotes cytochrome P450 http://purl.obolibrary.org/obo/CHEBI_38559
T97276 105893-105903 Chemical denotes cytochrome http://purl.obolibrary.org/obo/CHEBI_4056
T22765 105910-105913 Chemical denotes CYP http://purl.obolibrary.org/obo/CHEBI_38559
T14085 105933-105946 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T55445 105962-105972 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T52742 106014-106017 Chemical denotes UDP http://purl.obolibrary.org/obo/CHEBI_17659|http://purl.obolibrary.org/obo/CHEBI_58223
T91 106203-106221 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T93 106212-106221 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T84290 106235-106245 Chemical denotes atazanavir http://purl.obolibrary.org/obo/CHEBI_37924
T94858 106246-106255 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T64009 106266-106269 Chemical denotes CYP http://purl.obolibrary.org/obo/CHEBI_38559
T31065 106340-106353 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T66339 106520-106533 Chemical denotes buprenorphine http://purl.obolibrary.org/obo/CHEBI_3216
T71773 106579-106589 Chemical denotes atazanavir http://purl.obolibrary.org/obo/CHEBI_37924
T59554 106707-106710 Chemical denotes CYP http://purl.obolibrary.org/obo/CHEBI_38559
T96679 106799-106808 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T13987 106813-106832 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T71378 106822-106832 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T12801 106980-106989 Chemical denotes efavirenz http://purl.obolibrary.org/obo/CHEBI_119486
T21399 106994-107004 Chemical denotes nevirapine http://purl.obolibrary.org/obo/CHEBI_63613
T63149 107012-107015 Chemical denotes CYP http://purl.obolibrary.org/obo/CHEBI_38559
T42314 107071-107080 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T83783 107170-107179 Chemical denotes methadone http://purl.obolibrary.org/obo/CHEBI_6807
T110 107214-107223 Chemical denotes efavirenz http://purl.obolibrary.org/obo/CHEBI_119486
T76240 107227-107237 Chemical denotes nevirapine http://purl.obolibrary.org/obo/CHEBI_63613
T112 107325-107334 Chemical denotes Oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T10495 107362-107381 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T70158 107362-107371 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T42172 107372-107381 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T41667 107394-107403 Chemical denotes oxycodone http://purl.obolibrary.org/obo/CHEBI_7852
T51574 107448-107452 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T68581 107577-107582 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T94849 107686-107690 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T61019 107728-107732 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T121 107777-107781 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T51878 107847-107852 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T55237 108156-108160 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T22828 108161-108171 Chemical denotes amprenavir http://purl.obolibrary.org/obo/CHEBI_40050
T81667 108197-108207 Chemical denotes amprenavir http://purl.obolibrary.org/obo/CHEBI_40050
T37855 108426-108430 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T15495 108764-108768 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T47874 108866-108874 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T35335 108904-108916 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T1635 108918-108928 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T51586 108933-108941 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T133 108965-108973 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T135 109061-109066 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T25577 109150-109162 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T137 109167-109175 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T2314 109220-109224 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T98558 109242-109249 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45522 109280-109288 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T60669 109378-109383 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T25269 109693-109698 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T54061 109824-109834 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T71638 109835-109867 Chemical denotes reverse transcriptase inhibitors http://purl.obolibrary.org/obo/CHEBI_53756|http://purl.obolibrary.org/obo/CHEBI_59897
T38912 109843-109867 Chemical denotes transcriptase inhibitors http://purl.obolibrary.org/obo/CHEBI_37416
T147 109857-109867 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T31350 109884-109894 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T149 109895-109927 Chemical denotes reverse transcriptase inhibitors http://purl.obolibrary.org/obo/CHEBI_53756|http://purl.obolibrary.org/obo/CHEBI_59897
T20701 109903-109927 Chemical denotes transcriptase inhibitors http://purl.obolibrary.org/obo/CHEBI_37416
T94314 109917-109927 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T20334 110033-110038 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T8519 110254-110263 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T1783 110268-110279 Chemical denotes raltegravir http://purl.obolibrary.org/obo/CHEBI_82960
T11420 110476-110488 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T157 110490-110499 Chemical denotes tenofovir http://purl.obolibrary.org/obo/CHEBI_134504|http://purl.obolibrary.org/obo/CHEBI_63625|http://purl.obolibrary.org/obo/CHEBI_63716
T41404 110504-110517 Chemical denotes emtricitabine http://purl.obolibrary.org/obo/CHEBI_31536
T85995 110802-110811 Chemical denotes tenofovir http://purl.obolibrary.org/obo/CHEBI_134504|http://purl.obolibrary.org/obo/CHEBI_63625|http://purl.obolibrary.org/obo/CHEBI_63716
T97760 110888-110896 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T53034 111018-111026 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T72635 111084-111089 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T51837 111149-111154 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T75569 111245-111253 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T74415 111309-111317 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T27245 111607-111615 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T2343 111731-111739 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T65582 111792-111800 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T460 112319-112321 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T80200 112341-112344 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T97440 112549-112551 Chemical denotes MM http://purl.obolibrary.org/obo/CHEBI_53458|http://purl.obolibrary.org/obo/CHEBI_74707
T33787 112572-112574 Chemical denotes SF http://purl.obolibrary.org/obo/CHEBI_71029

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
11 1282-1299 Gene denotes μ-opioid receptor Gene:4988
12 1301-1304 Gene denotes MOR Gene:4988
13 207-235 Species denotes human immunodeficiency virus Tax:12721
14 837-842 Species denotes HIV-1 Tax:11676
15 1239-1244 Species denotes HIV-1 Tax:11676
16 237-240 Species denotes HIV Tax:12721
17 438-441 Species denotes HIV Tax:12721
18 804-807 Species denotes HIV Tax:12721
19 1049-1052 Species denotes HIV Tax:12721
20 1310-1313 Species denotes HIV Tax:12721
21 602-654 Disease denotes neuroHIV and HIV-associated neurocognitive disorders MESH:D020943
24 1846-1870 Gene denotes some efflux transporters
25 1602-1605 Species denotes HIV Tax:12721
40 3260-3264 Gene denotes Nath Gene:80155
41 2088-2094 Species denotes people Tax:9606
42 3044-3049 Species denotes Human Tax:9606
43 3179-3182 Species denotes HIV Tax:12721
44 3343-3346 Species denotes HIV Tax:12721
45 3569-3572 Species denotes HIV Tax:12721
46 1958-1970 Disease denotes Opioid abuse MESH:D009293
47 2466-2471 Disease denotes death MESH:D003643
48 2583-2591 Disease denotes overdose MESH:D062787
49 2600-2606 Disease denotes deaths MESH:D003643
50 2839-2847 Disease denotes overdose MESH:D062787
51 2880-2893 Disease denotes constant rise MESH:D014717
52 2897-2903 Disease denotes deaths MESH:D003643
53 3131-3174 Disease denotes immunodeficiency virus (HIV) and drug abuse MESH:D019966
64 3855-3865 Species denotes SARS-CoV-2 Tax:2697049
65 4282-4295 Chemical denotes buprenorphine MESH:D002047
66 3702-3710 Disease denotes COVID-19 MESH:C000657245
67 3744-3750 Disease denotes Becker MESH:D009224
68 3891-3900 Disease denotes infection MESH:D007239
69 3981-4005 Disease denotes heightening opioid abuse MESH:D009293
70 4021-4043 Disease denotes respiratory depression MESH:D012131
71 4115-4123 Disease denotes overdose MESH:D062787
72 4125-4131 Disease denotes Becker MESH:D009224
73 4365-4373 Disease denotes COVID-19 MESH:C000657245
85 4788-4797 Chemical denotes methadone MESH:D008691
86 4872-4878 Chemical denotes heroin MESH:D003932
87 5029-5037 Chemical denotes fentanyl MESH:D005283
88 5136-5144 Chemical denotes fentanyl MESH:D005283
89 5278-5286 Chemical denotes fentanyl MESH:D005283
90 5337-5345 Chemical denotes morphine MESH:D009020
91 5587-5595 Chemical denotes fentanyl MESH:D005283
92 4702-4717 Disease denotes overdose deaths MESH:D062787
93 4919-4934 Disease denotes overdose deaths MESH:D062787
94 5079-5088 Disease denotes mortality MESH:D003643
95 5459-5469 Disease denotes overdosing MESH:D062787
103 5771-5783 Disease denotes opioid abuse MESH:D009293
104 5996-6006 Disease denotes drowsiness MESH:D006970
105 6012-6030 Disease denotes sleep disturbances MESH:D012893
106 6222-6256 Disease denotes cognitive and psychomotor deficits MESH:D003072
107 6412-6416 Disease denotes pain MESH:D010146
108 6444-6456 Disease denotes hyperalgesia MESH:D006930
109 6500-6513 Disease denotes hyperkatifeia
119 7421-7426 Gene denotes TNF-α Gene:7124
120 7428-7433 Gene denotes IL-1β Gene:3552
121 7964-7967 Species denotes HIV Tax:12721
122 7657-7665 Chemical denotes nitrogen MESH:D009584
123 7675-7678 Chemical denotes RNS MESH:D026361
124 7688-7701 Chemical denotes peroxynitrite MESH:D030421
125 7053-7064 Disease denotes brain edema MESH:D001929
126 7081-7093 Disease denotes astrogliosis
127 7318-7325 Disease denotes gliosis MESH:D005911
143 9107-9115 Gene denotes GSK-3α/β Gene:2931
144 9196-9221 Gene denotes cyclin-dependent kinase-5 Gene:1020
145 9223-9228 Gene denotes Cdk-5 Gene:1020
146 9121-9124 Gene denotes pan Gene:51816
147 8042-8048 Chemical denotes heroin MESH:D003932
148 8049-8063 Disease denotes overdose death MESH:D062787
149 8119-8142 Disease denotes neurovascular disorders MESH:D013901
150 8144-8180 Disease denotes hypoxic ischemic leukoencephalopathy MESH:D056784
151 8202-8209 Disease denotes atrophy MESH:D001284
152 8764-8776 Disease denotes hypothalamus MESH:D007029
153 8814-8833 Disease denotes leukoencephalopathy MESH:D056784
154 8835-8842 Disease denotes atrophy MESH:D001284
155 8963-8975 Disease denotes opiate abuse MESH:D009293
156 9476-9487 Disease denotes Alzheimer’s MESH:D000544
157 9580-9600 Disease denotes cognitive impairment MESH:D003072
161 10054-10057 Species denotes HIV Tax:12721
162 9633-9639 Chemical denotes heroin MESH:D003932
163 9856-9868 Disease denotes inflammation MESH:D007249
175 10768-10771 Gene denotes MOR Gene:4988
176 10777-10780 Gene denotes DOR Gene:58476
177 11281-11301 Gene denotes Toll-like receptor 4 Gene:7099
178 11303-11307 Gene denotes TLR4 Gene:7099
179 11471-11504 Gene denotes myeloid differentiation protein-2 Gene:23643
180 11865-11869 Gene denotes TLR4 Gene:7099
181 11657-11660 Species denotes HIV Tax:12721
182 10495-10503 Chemical denotes morphine MESH:D009020
183 10620-10628 Chemical denotes morphine MESH:D009020
184 11239-11247 Chemical denotes morphine MESH:D009020
185 10595-10619 Disease denotes glial inflammation block MESH:D007249
188 12225-12228 Species denotes HIV Tax:12721
189 12155-12167 Disease denotes opioid abuse MESH:D009293
191 12291-12309 Disease denotes HIV Neuropathology MESH:D015658
228 13918-13921 Gene denotes MOR Gene:4988
229 14049-14052 Gene denotes MOR Gene:4988
230 14090-14094 Gene denotes CCR5 Gene:1234
231 14159-14164 Gene denotes CXCR4 Gene:7852
232 14406-14409 Gene denotes MOR Gene:4988
233 14410-14414 Gene denotes CCR5 Gene:1234
234 14418-14423 Gene denotes CXCR4 Gene:7852
235 14720-14723 Gene denotes Tat Gene:6898
236 14835-14839 Gene denotes CCR5 Gene:12774
237 14947-14950 Gene denotes Tat Gene:234724
238 12718-12722 Gene denotes Nath Gene:80155
240 14099-14103 Gene denotes Hage Gene:55510
241 12441-12447 Species denotes People Tax:9606
242 13124-13130 Species denotes Lemons Tax:2708
243 14978-14982 Species denotes mice Tax:10090
244 12462-12465 Species denotes HIV Tax:12721
245 12713-12716 Species denotes HIV Tax:12721
246 12793-12796 Species denotes HIV Tax:12721
247 13946-13949 Species denotes HIV Tax:12721
248 14057-14060 Species denotes HIV Tax:12721
249 14546-14549 Species denotes HIV Tax:12721
250 14743-14751 Chemical denotes morphine MESH:D009020
251 14845-14854 Chemical denotes maraviroc MESH:D000077592
252 14866-14874 Chemical denotes morphine MESH:D009020
253 14960-14968 Chemical denotes morphine MESH:D009020
254 12448-12456 Disease denotes infected MESH:D007239
255 12826-12830 Disease denotes pain MESH:D010146
256 12852-12875 Disease denotes peripheral neuropathies MESH:D010523
258 13840-13866 Disease denotes immune deficiency syndrome MESH:D007153
259 13868-13872 Disease denotes AIDS MESH:D000163
524 17372-17375 Gene denotes CD4 Gene:920
525 17482-17485 Gene denotes OST Gene:1650
526 17526-17529 Gene denotes p24 Gene:140767
527 17617-17621 Gene denotes CD68 Gene:968
528 17772-17775 Gene denotes OST Gene:1650
529 17868-17872 Gene denotes CD68 Gene:968
530 17974-17978 Gene denotes CD68 Gene:968
531 18033-18037 Gene denotes CD68 Gene:968
532 18163-18168 Gene denotes TNF-α Gene:7124
533 18252-18258 Gene denotes MIP-1α Gene:6348
534 18260-18266 Gene denotes MIP-1β Gene:6351
535 18268-18273 Gene denotes MCP-2 Gene:6355
536 18314-18318 Gene denotes CCR5 Gene:1234
537 18602-18605 Gene denotes OST Gene:1650
538 19168-19171 Gene denotes OST Gene:1650
539 20139-20142 Gene denotes OST Gene:1650
540 20180-20184 Gene denotes PENK Gene:5179
541 20227-20231 Gene denotes PENK Gene:5179
542 20376-20381 Gene denotes OPRM1 Gene:4988
543 20434-20437 Gene denotes MOR Gene:4988
544 20570-20575 Gene denotes OPRM1 Gene:4988
545 20715-20719 Gene denotes CCL2 Gene:6347
546 20727-20731 Gene denotes CCL5 Gene:6352
547 20741-20746 Gene denotes CXCR4 Gene:7852
548 20748-20752 Gene denotes CCR5 Gene:1234
549 20821-20825 Gene denotes OPRK Gene:4986
550 20830-20834 Gene denotes PDYN Gene:5173
551 20866-20870 Gene denotes OPRK Gene:4986
552 20875-20879 Gene denotes PDYN Gene:5173
553 21404-21407 Gene denotes CD4 Gene:713807
554 21663-21666 Gene denotes CD4 Gene:920
555 21917-21920 Gene denotes CD4 Gene:920
556 22096-22099 Gene denotes CD4 Gene:713807
557 22215-22218 Gene denotes CD4 Gene:713807
558 22670-22675 Gene denotes PSD95 Gene:1742
559 22961-22967 Gene denotes PDGF-B Gene:703173
560 23010-23016 Gene denotes PDGF-B Gene:703173
561 23167-23171 Gene denotes Tat1 Gene:72472
562 23436-23441 Gene denotes HSPA5 Gene:14828
563 23450-23455 Gene denotes HSPA5 Gene:14828
564 23999-24003 Gene denotes Tat1 Gene:72472
565 24053-24057 Gene denotes Iba1 Gene:114737
566 24082-24085 Gene denotes Tat Gene:234724
567 24125-24129 Gene denotes Tat1 Gene:72472
568 24204-24208 Gene denotes CCL2 Gene:20296
569 24239-24243 Gene denotes CCR5 Gene:12774
570 24248-24252 Gene denotes CCL2 Gene:20296
571 24280-24284 Gene denotes CCL2 Gene:20296
572 24312-24315 Gene denotes Tat Gene:234724
573 24477-24480 Gene denotes Tat Gene:234724
574 24507-24511 Gene denotes TNFα Gene:21926
575 24513-24517 Gene denotes IL-6 Gene:16193
576 24519-24523 Gene denotes CCL2 Gene:20296
577 24529-24533 Gene denotes TLR2 Gene:24088
578 24535-24539 Gene denotes TLR4 Gene:21898
579 24541-24545 Gene denotes TLR9 Gene:81897
580 24607-24610 Gene denotes MOR Gene:4988
581 24632-24637 Gene denotes gp120 Gene:3700
582 24702-24705 Gene denotes MOR Gene:4988
583 24738-24742 Gene denotes Tat1 Gene:116369
584 24846-24849 Gene denotes CPu Gene:56373
585 24920-24923 Gene denotes Tat Gene:234724
586 25038-25042 Gene denotes Tat1 Gene:72472
587 25223-25227 Gene denotes CCR5 Gene:12774
588 25244-25247 Gene denotes Tat Gene:234724
589 25401-25405 Gene denotes Brd4 Gene:362844
590 25423-25428 Gene denotes gp120 Gene:3700
591 25480-25484 Gene denotes Tat1 Gene:170566
592 25583-25586 Gene denotes Tat Gene:234724
593 25659-25663 Gene denotes Tat1 Gene:72472
594 25763-25766 Gene denotes Tat Gene:234724
595 25818-25822 Gene denotes Tat1 Gene:72472
596 25946-25949 Gene denotes Tat Gene:234724
597 26123-26127 Gene denotes Tat1 Gene:116369
598 26201-26204 Gene denotes Tat Gene:234724
599 26352-26355 Gene denotes Tat Gene:234724
600 26538-26543 Gene denotes CXCR4 Gene:7852
601 26548-26552 Gene denotes CCR5 Gene:1234
602 26826-26829 Gene denotes Tat Gene:234724
603 26882-26886 Gene denotes Tat1 Gene:72472
604 26968-26971 Gene denotes Tat Gene:234724
605 17022-17027 Species denotes human Tax:9606
606 17207-17212 Species denotes Human Tax:9606
607 17310-17315 Species denotes Human Tax:9606
608 17317-17323 Species denotes Lemons Tax:2708
609 17383-17388 Species denotes Human Tax:9606
610 17530-17535 Species denotes Human Tax:9606
611 17669-17674 Species denotes Human Tax:9606
612 17801-17806 Species denotes Human Tax:9606
613 17873-17878 Species denotes Human Tax:9606
614 18038-18043 Species denotes Human Tax:9606
615 18189-18194 Species denotes Human Tax:9606
616 18343-18348 Species denotes Human Tax:9606
617 18470-18475 Species denotes Human Tax:9606
618 18579-18588 Species denotes marijuana Tax:3483
619 18711-18716 Species denotes Human Tax:9606
620 18853-18858 Species denotes Human Tax:9606
621 18953-18958 Species denotes Human Tax:9606
622 19013-19022 Species denotes marijuana Tax:3483
623 19076-19081 Species denotes Human Tax:9606
624 19172-19177 Species denotes Human Tax:9606
625 19332-19337 Species denotes Human Tax:9606
626 19492-19497 Species denotes women Tax:9606
627 19561-19566 Species denotes Human Tax:9606
628 19744-19749 Species denotes Human Tax:9606
629 19831-19836 Species denotes Human Tax:9606
630 19924-19929 Species denotes Human Tax:9606
631 20050-20055 Species denotes Human Tax:9606
632 20151-20156 Species denotes Human Tax:9606
633 20330-20335 Species denotes Human Tax:9606
634 20496-20503 Species denotes tobacco Tax:4097
635 20525-20530 Species denotes Human Tax:9606
636 20631-20636 Species denotes Human Tax:9606
637 20777-20782 Species denotes Human Tax:9606
638 20935-20940 Species denotes Human Tax:9606
639 21066-21071 Species denotes Human Tax:9606
640 21315-21330 Species denotes Rhesus macaques Tax:9544
641 21485-21500 Species denotes Rhesus macaques Tax:9544
642 21702-21717 Species denotes Rhesus macaques Tax:9544
643 22017-22032 Species denotes Rhesus macaques Tax:9544
644 22594-22599 Species denotes HIV-1 Tax:11676
645 22737-22742 Species denotes Mouse Tax:10090
646 22850-22853 Species denotes Rat Tax:10116
647 22855-22860 Species denotes HIV-1 Tax:11676
648 23077-23092 Species denotes Rhesus macaques Tax:9544
649 23232-23237 Species denotes Mouse Tax:10090
650 23472-23487 Species denotes Rhesus macaques Tax:9544
651 23489-23494 Species denotes Human Tax:9606
652 23711-23726 Species denotes Rhesus macaques Tax:9544
653 23945-23960 Species denotes Rhesus macaques Tax:9544
654 24075-24080 Species denotes Mouse Tax:10090
655 24341-24346 Species denotes Mouse Tax:10090
656 24546-24551 Species denotes Mouse Tax:10090
657 24622-24627 Species denotes HIV-1 Tax:11676
658 24661-24665 Species denotes Rats Tax:10116
659 24667-24672 Species denotes HIV-1 Tax:11676
660 24908-24912 Species denotes mice Tax:10090
661 24913-24918 Species denotes Mouse Tax:10090
662 25237-25242 Species denotes Mouse Tax:10090
663 25411-25414 Species denotes Rat Tax:10116
664 25576-25581 Species denotes Mouse Tax:10090
665 25756-25761 Species denotes Mouse Tax:10090
666 25939-25944 Species denotes Mouse Tax:10090
667 26084-26099 Species denotes Rhesus macaques Tax:9544
668 26194-26199 Species denotes Mouse Tax:10090
669 26345-26350 Species denotes Mouse Tax:10090
670 26486-26499 Species denotes S. pneumoniae Tax:1313
671 26578-26583 Species denotes Mouse Tax:10090
672 26600-26613 Species denotes S. pneumoniae Tax:1313
673 26819-26824 Species denotes Mouse Tax:10090
674 26961-26966 Species denotes Mouse Tax:10090
675 16944-16947 Species denotes HIV Tax:12721
676 17029-17032 Species denotes HIV Tax:12721
677 17522-17525 Species denotes HIV Tax:12721
678 17660-17663 Species denotes HIV Tax:12721
679 17826-17829 Species denotes HIV Tax:12721
680 17919-17922 Species denotes HIV Tax:12721
681 17989-17992 Species denotes HIV Tax:12721
682 18378-18381 Species denotes HIV Tax:12721
683 18439-18442 Species denotes HIV Tax:12721
684 18544-18547 Species denotes HIV Tax:12721
685 18688-18691 Species denotes HIV Tax:12721
686 18887-18890 Species denotes HIV Tax:12721
687 18978-18981 Species denotes HIV Tax:12721
688 19446-19449 Species denotes HIV Tax:12721
689 19515-19518 Species denotes HIV Tax:12721
690 19721-19724 Species denotes HIV Tax:12721
691 19781-19784 Species denotes HIV Tax:12721
692 19866-19869 Species denotes HIV Tax:12721
693 19977-19980 Species denotes HIV Tax:12721
694 20096-20099 Species denotes HIV Tax:12721
695 20196-20199 Species denotes HIV Tax:12721
696 20244-20247 Species denotes HIV Tax:12721
697 20259-20262 Species denotes HIV Tax:12721
698 20275-20278 Species denotes HIV Tax:12721
699 20413-20416 Species denotes HIV Tax:12721
700 20553-20556 Species denotes HIV Tax:12721
701 20600-20603 Species denotes HIV Tax:12721
702 20662-20665 Species denotes HIV Tax:12721
703 20849-20852 Species denotes HIV Tax:12721
704 20904-20907 Species denotes HIV Tax:12721
705 21138-21141 Species denotes HIV Tax:12721
706 21196-21200 Species denotes SHIV Tax:57667
707 21539-21542 Species denotes HIV Tax:12721
708 21589-21593 Species denotes SHIV Tax:57667
709 21840-21844 Species denotes SHIV Tax:57667
710 22776-22779 Species denotes HIV Tax:12721
711 22832-22835 Species denotes HIV Tax:12721
712 24392-24395 Species denotes HIV Tax:12721
713 23896-23899 Gene denotes SIV Gene:8114
714 23413-23416 Gene denotes SIV Gene:8114
715 23002-23005 Gene denotes SIV Gene:8114
716 22444-22447 Gene denotes SIV Gene:8114
717 22272-22275 Gene denotes SIV Gene:8114
718 22146-22149 Gene denotes SIV Gene:8114
719 21969-21972 Gene denotes SIV Gene:8114
720 21775-21778 Gene denotes SIV Gene:8114
721 21698-21701 Gene denotes SIV Gene:8114
722 20105-20108 Gene denotes OST Gene:1650
723 19989-19992 Gene denotes OST Gene:1650
724 19875-19878 Gene denotes OST Gene:1650
725 19793-19796 Gene denotes OST Gene:1650
726 19637-19640 Gene denotes OST Gene:1650
727 19139-19142 Gene denotes OST Gene:1650
728 25289-25294 Gene denotes gp120 Gene:3700
729 22588-22593 Gene denotes gp120 Gene:3700
730 22111-22114 Gene denotes nef Gene:6285
732 26660-26663 Gene denotes Tat Gene:6898
733 26423-26426 Gene denotes Tat Gene:6898
734 26251-26254 Gene denotes Tat Gene:6898
735 24904-24907 Gene denotes Tat Gene:6898
736 24396-24399 Gene denotes Tat Gene:6898
737 23444-23447 Gene denotes Tat Gene:6898
738 22898-22901 Gene denotes Tat Gene:6898
739 21989-21992 Gene denotes tat Gene:6898
740 21930-21933 Gene denotes tat Gene:6898
741 24351-24355 Gene denotes Hage Gene:55510
742 18333-18336 Gene denotes CD4 Gene:920
743 22320-22323 Gene denotes CSF Gene:3918
744 21430-21433 Gene denotes CSF Gene:3918
745 21257-21260 Gene denotes CSF Gene:3918
746 25327-25335 Chemical denotes Morphine MESH:D009020
747 25453-25461 Chemical denotes Morphine MESH:D009020
748 25491-25499 Chemical denotes Morphine MESH:D009020
749 26726-26738 Chemical denotes Dolutegravir MESH:C562325
750 26743-26751 Chemical denotes abacavir MESH:C106538
751 26770-26780 Chemical denotes lamivudine MESH:D019259
752 26794-26802 Chemical denotes morphine MESH:D009020
753 26893-26901 Chemical denotes Morphine MESH:D009020
754 17052-17080 Disease denotes ARV adherence HIV cART • SUD MESH:D015658
755 17108-17112 Disease denotes pain MESH:D010146
756 17196-17200 Disease denotes pain MESH:D010146
757 17233-17245 Disease denotes HIV cART OUD MESH:D015658
758 17337-17344 Disease denotes HIV ARV MESH:D015658
759 17413-17462 Disease denotes HIV encephalitis (HIVE) HIV infection CNS HIV ZDV MESH:D015658
760 17595-17614 Disease denotes HIV • ARV • ZDV OUD MESH:D015658
761 17713-17728 Disease denotes HIV • ARV • ZDV MESH:D015658
762 18098-18110 Disease denotes HIV cART OUD MESH:D015658
763 18214-18221 Disease denotes HIV ARV MESH:D015658
764 18306-18309 Disease denotes LPS MESH:C536528
765 18638-18654 Disease denotes hypersensitivity MESH:D004342
766 18740-18759 Disease denotes Learning-memory HIV MESH:D007859
767 18819-18852 Disease denotes Learning slope • ↓ Delayed recall MESH:D008569
768 18920-18952 Disease denotes Recall memory • ↓ Working memory MESH:D008569
769 19202-19247 Disease denotes Cognitive function HIV cART OUD • ↓ Cognitive MESH:D003072
770 19358-19396 Disease denotes Memory Cognitive function HIV cART SUD MESH:D015658
771 19588-19621 Disease denotes Visual and cognitive function HIV MESH:D003072
772 20966-21020 Disease denotes Sensory Neuropathy HIV cART SUD HIV sensory neuropathy MESH:D000699
773 22460-22469 Disease denotes mortality MESH:D003643
774 22544-22559 Disease denotes Neuronal injury MESH:D009410
775 22695-22723 Disease denotes withdrawal • ↑ Sphingomyelin MESH:D013375
776 23504-23517 Disease denotes neuroblastoma MESH:D009447
777 23534-23542 Disease denotes Pendyala
778 23649-23670 Disease denotes demyelinating lesions MESH:D003711
779 24468-24473 Disease denotes death MESH:D003643
780 24493-24502 Disease denotes infection MESH:D007239
781 25278-25288 Disease denotes Neuropathy MESH:D009422
782 25378-25396 Disease denotes Mechanic allodynia MESH:D006930
783 26500-26508 Disease denotes infected MESH:D007239
784 26589-26598 Disease denotes infection MESH:D007239
785 23496-23503 CellLine denotes SH-SY5Y CVCL:0019
786 20429-20433 Mutation denotes C17T rs1799972
787 22405-22409 Mutation denotes R50G p.R50G
789 27012-27019 Gene denotes Clade B
804 27203-27207 Gene denotes Brd4 Gene:23476
805 27209-27241 Gene denotes Bromodomain-containing protein 4 Gene:23476
806 27243-27246 Gene denotes CPu Gene:1361
807 27526-27531 Gene denotes HSPA5 Gene:3309
808 27635-27639 Gene denotes Iba1 Gene:199
809 27641-27683 Gene denotes ionized calcium-binding adapter molecule 1 Gene:199
810 27802-27805 Gene denotes MOR Gene:4988
811 27807-27824 Gene denotes μ-opioid receptor Gene:4988
812 27874-27877 Gene denotes OST Gene:1650
813 27958-27962 Gene denotes PENK Gene:5179
814 27964-27980 Gene denotes preproenkephalin Gene:5179
815 27353-27356 Gene denotes CSF Gene:3918
816 28109-28119 Species denotes transgenic Tax:10090
817 27482-27498 Disease denotes HIV encephalitis MESH:D004660
821 28395-28398 Species denotes HIV Tax:12721
822 28562-28565 Species denotes HIV Tax:12721
823 28677-28680 Species denotes HIV Tax:12721
843 15320-15323 Gene denotes CD4 Gene:920
844 16405-16408 Gene denotes CD4 Gene:920
845 15345-15348 Species denotes HIV Tax:12721
846 16793-16796 Species denotes HIV Tax:12721
847 15278-15284 Chemical denotes heroin MESH:D003932
848 15401-15407 Chemical denotes heroin MESH:D003932
849 15053-15057 Disease denotes AIDS MESH:D000163
850 15167-15179 Disease denotes opiate abuse MESH:D009293
851 15204-15220 Disease denotes HIV encephalitis MESH:D004660
852 15554-15559 Disease denotes death MESH:D003643
853 15565-15569 Disease denotes AIDS MESH:D000163
854 15592-15616 Disease denotes opportunistic infections MESH:D009894
855 15669-15692 Disease denotes HIV-associated dementia MESH:D015526
856 15694-15697 Disease denotes HAD MESH:C535310
857 15724-15763 Disease denotes HIV-associated neurocognitive disorders MESH:D020943
858 16046-16066 Disease denotes cognitive impairment MESH:D003072
859 16488-16497 Disease denotes tauopathy MESH:D024801
860 16523-16535 Disease denotes inflammation MESH:D007249
861 16674-16711 Disease denotes deficits in memory and working memory MESH:D008569
867 29165-29174 Species denotes Churchill Tax:868862
868 29020-29023 Species denotes HIV Tax:12721
869 29160-29163 Species denotes HIV Tax:12721
870 29474-29477 Species denotes HIV Tax:12721
871 29088-29097 Disease denotes infection MESH:D007239
1170 30715-30718 Gene denotes KOR Gene:4986
1171 30764-30767 Gene denotes KOR Gene:4986
1172 30779-30784 Gene denotes TNF-α Gene:7124
1173 30786-30790 Gene denotes IL-6 Gene:3569
1174 30938-30941 Gene denotes KOR Gene:4986
1175 30965-30968 Gene denotes KOR Gene:4986
1176 30980-30985 Gene denotes TNF-α Gene:7124
1177 31007-31010 Gene denotes p24 Gene:140767
1178 31080-31084 Gene denotes Tat1 Gene:72472
1179 31104-31108 Gene denotes CCL5 Gene:20304
1180 31110-31114 Gene denotes CCL2 Gene:20296
1181 31128-31135 Gene denotes Beclin1 Gene:56208
1182 31246-31249 Gene denotes Tat Gene:6898
1183 31277-31281 Gene denotes CCR5 Gene:1234
1184 31342-31346 Gene denotes IL-6 Gene:3569
1185 31351-31355 Gene denotes CCL5 Gene:6352
1186 31444-31447 Gene denotes MOR Gene:18390
1187 31449-31452 Gene denotes DOR Gene:18386
1188 31454-31457 Gene denotes KOR Gene:18387
1189 31469-31473 Gene denotes Tat1 Gene:72472
1190 31501-31504 Gene denotes DOR Gene:18386
1191 31512-31515 Gene denotes KOR Gene:18387
1192 31521-31530 Gene denotes Caspase-3 Gene:12367
1193 31560-31563 Gene denotes Tat Gene:234724
1194 31580-31583 Gene denotes DOR Gene:18386
1195 31585-31588 Gene denotes KOR Gene:18387
1196 31601-31604 Gene denotes Tat Gene:234724
1197 31669-31672 Gene denotes MOR Gene:18390
1198 31729-31733 Gene denotes Tat1 Gene:72472
1199 31751-31754 Gene denotes MOR Gene:18390
1200 31873-31876 Gene denotes MOR Gene:18390
1201 31881-31885 Gene denotes CCR5 Gene:12774
1202 31960-31964 Gene denotes CCR5 Gene:12774
1203 31996-32000 Gene denotes BDNF Gene:12064
1204 32078-32081 Gene denotes MOR Gene:4988
1205 32082-32086 Gene denotes CCR5 Gene:1234
1206 32156-32159 Gene denotes MOR Gene:4988
1207 32160-32164 Gene denotes CCR5 Gene:1234
1208 32251-32254 Gene denotes MOR Gene:4988
1209 32255-32259 Gene denotes CCR5 Gene:1234
1210 32301-32306 Gene denotes gp160 Gene:2028
1211 32311-32315 Gene denotes CCR5 Gene:1234
1212 32316-32319 Gene denotes CD4 Gene:920
1213 32530-32533 Gene denotes p24 Gene:140767
1214 32540-32543 Gene denotes Tat Gene:6898
1215 37974-37998 Gene denotes lular ARV concentrations Gene:6347
1342 30912-30915 Gene denotes U69 Gene:26779
1343 30902-30905 Gene denotes U50 Gene:692088
1344 30706-30709 Gene denotes U50 Gene:692088
1346 34549-34552 Gene denotes p24 Gene:140767
1347 32131-32134 Gene denotes MOR Gene:4988
1354 31386-31390 Gene denotes Hage Gene:55510
1355 30733-30738 Species denotes HIV-1 Tax:11676
1356 30808-30813 Species denotes Human Tax:9606
1357 31011-31016 Species denotes Human Tax:9606
1358 31161-31166 Species denotes Mouse Tax:10090
1359 31240-31245 Species denotes HIV-1 Tax:11676
1360 31356-31361 Species denotes Human Tax:9606
1361 31618-31623 Species denotes Mouse Tax:10090
1362 31823-31828 Species denotes Mouse Tax:10090
1363 32012-32017 Species denotes Mouse Tax:10090
1364 32341-32346 Species denotes Human Tax:9606
1365 32669-32674 Species denotes Human Tax:9606
1366 37999-38004 Species denotes Human Tax:9606
1370 38482-38487 Species denotes Mouse Tax:10090
1405 30589-30592 Species denotes HIV Tax:12721
1406 30670-30673 Species denotes HIV Tax:12721
1407 30685-30688 Species denotes HIV Tax:12721
1408 31003-31006 Species denotes HIV Tax:12721
1409 32062-32065 Species denotes HIV Tax:12721
1410 32297-32300 Species denotes HIV Tax:12721
1411 32436-32439 Species denotes HIV Tax:12721
1412 32526-32529 Species denotes HIV Tax:12721
1413 32729-32732 Species denotes HIV Tax:12721
1414 34545-34548 Species denotes HIV Tax:12721
1437 30834-30846 Disease denotes HIV-infected MESH:D015658
1438 31551-31556 Disease denotes death MESH:D003643
1439 31802-31822 Disease denotes immature glial death MESH:D003643
1440 32181-32201 Disease denotes blocks HIV infection MESH:D015658
1441 32488-32504 Disease denotes astroglia HIVBaL
1458 32331-32334 CellLine denotes HEK CVCL:M624
1459 32382-32390 CellLine denotes HEK-293T CVCL:0063
1469 39502-39509 Gene denotes Clade B
1482 39809-39812 Gene denotes DOR Gene:58476
1483 39955-39959 Gene denotes Iba1 Gene:199
1484 39961-40003 Gene denotes ionized calcium-binding adapter molecule 1 Gene:199
1485 40005-40010 Gene denotes JAM-1 Gene:50848
1486 40012-40042 Gene denotes junctional adhesion molecule-1 Gene:50848
1487 40044-40048 Gene denotes KCC2 Gene:57468
1488 40050-40072 Gene denotes K+-Cl− cotransporter 2 Gene:57468
1489 40074-40077 Gene denotes KOR Gene:4986
1490 40079-40096 Gene denotes κ-opioid receptor Gene:4986
1491 40170-40173 Gene denotes MOR Gene:4988
1492 40175-40192 Gene denotes μ-opioid receptor Gene:4988
1493 40125-40128 Disease denotes ΔΨm
1497 40723-40726 Species denotes HIV Tax:12721
1498 40853-40856 Species denotes HIV Tax:12721
1499 40968-40971 Species denotes HIV Tax:12721
1501 30119-30122 Species denotes HIV Tax:12721
1503 41068-41071 Species denotes HIV Tax:12721
1514 41758-41761 Gene denotes CD4 Gene:920
1517 41331-41340 Species denotes Churchill Tax:868862
1518 41419-41424 Species denotes human Tax:9606
1519 41688-41697 Species denotes Churchill Tax:868862
1520 41578-41581 Species denotes HIV Tax:12721
1521 41165-41174 Disease denotes infection MESH:D007239
1523 41630-41642 Disease denotes HIV-infected MESH:D015658
1549 42006-42009 Gene denotes MOR Gene:4988
1550 42517-42520 Gene denotes MOR Gene:4988
1551 42612-42615 Gene denotes Tat Gene:6898
1552 42695-42698 Gene denotes MOR Gene:4988
1553 42768-42771 Gene denotes Tat Gene:6898
1554 42830-42833 Gene denotes Tat Gene:6898
1555 42903-42911 Gene denotes Beclin-1 Gene:8678
1556 43285-43288 Gene denotes MOR Gene:4988
1557 42259-42262 Gene denotes MOR Gene:4988
1558 43348-43352 Gene denotes Hage Gene:55510
1559 43209-43213 Gene denotes Hage Gene:55510
1560 42240-42244 Gene denotes Hage Gene:55510
1561 42195-42199 Gene denotes Hage Gene:55510
1562 43141-43146 Species denotes HIV-1 Tax:11676
1563 43106-43109 Species denotes HIV Tax:12721
1564 42570-42578 Chemical denotes morphine MESH:D009020
1565 42721-42729 Chemical denotes morphine MESH:D009020
1566 42863-42871 Chemical denotes morphine MESH:D009020
1567 41996-42004 Disease denotes infected MESH:D007239
1568 42022-42032 Disease denotes HIV or HIV MESH:D015658
1569 42379-42400 Disease denotes HIV neuropathogenesis MESH:D015658
1570 42603-42608 Disease denotes death MESH:D003643
1571 42746-42756 Disease denotes neurotoxic MESH:D020258
1572 43182-43195 Disease denotes neurotoxicity MESH:D020258
1573 43247-43261 Disease denotes neuronal death MESH:D009410
1627 44949-44953 Gene denotes CCL5 Gene:6352
1628 44977-44981 Gene denotes CCL2 Gene:6347
1629 45099-45130 Gene denotes glial fibrillary acidic protein Gene:14580
1630 45132-45136 Gene denotes GFAP Gene:14580
1631 45198-45202 Gene denotes CCR2 Gene:12772
1632 45235-45239 Gene denotes CCL2 Gene:20296
1633 45255-45272 Gene denotes μ-opioid receptor Gene:18390
1634 45274-45277 Gene denotes MOR Gene:18390
1635 45347-45351 Gene denotes CCR2 Gene:729230
1636 45395-45398 Gene denotes Tat Gene:6898
1637 45431-45435 Gene denotes GFAP Gene:2670
1638 45562-45565 Gene denotes Tat Gene:234724
1639 45655-45658 Gene denotes Tat Gene:234724
1640 45722-45726 Gene denotes CCL2 Gene:20296
1641 45830-45834 Gene denotes CCL5 Gene:20304
1642 45872-45875 Gene denotes Tat Gene:234724
1643 45978-45982 Gene denotes CCL5 Gene:20304
1644 46019-46023 Gene denotes CCL2 Gene:20296
1645 46095-46098 Gene denotes Tat Gene:234724
1646 46144-46148 Gene denotes CCL5 Gene:20304
1647 46193-46197 Gene denotes CCL5 Gene:20304
1648 46221-46225 Gene denotes GFAP Gene:14580
1649 46448-46452 Gene denotes CCL5 Gene:6352
1650 46468-46472 Gene denotes CCR5 Gene:1234
1651 46496-46500 Gene denotes CCL2 Gene:6347
1652 47106-47110 Gene denotes BDNF Gene:627
1653 47118-47122 Gene denotes BDNF Gene:627
1654 47124-47129 Gene denotes mBDNF Gene:12064
1655 46281-46284 Gene denotes Tat Gene:234724
1656 47283-47287 Gene denotes Hage Gene:55510
1657 47209-47213 Gene denotes Hage Gene:55510
1658 46354-46358 Gene denotes Hage Gene:55510
1659 46173-46177 Gene denotes Hage Gene:55510
1660 45616-45620 Gene denotes Hage Gene:55510
1661 44894-44899 Species denotes HIV-1 Tax:11676
1662 45176-45180 Species denotes mice Tax:10090
1663 45389-45394 Species denotes HIV-1 Tax:11676
1664 45516-45520 Species denotes mice Tax:10090
1665 45601-45605 Species denotes mice Tax:10090
1666 45649-45653 Species denotes mice Tax:10090
1667 45840-45844 Species denotes mice Tax:10090
1668 45908-45912 Species denotes mice Tax:10090
1669 45962-45966 Species denotes mice Tax:10090
1670 45988-45992 Species denotes mice Tax:10090
1671 46158-46162 Species denotes mice Tax:10090
1672 46333-46337 Species denotes mice Tax:10090
1673 46393-46398 Species denotes HIV-1 Tax:11676
1674 45002-45005 Species denotes HIV Tax:12721
1675 45401-45409 Chemical denotes morphine MESH:D009020
1676 44908-44924 Disease denotes CNS inflammation MESH:D007249
1677 46407-46423 Disease denotes CNS inflammation MESH:D007249
1678 46609-46621 Disease denotes inflammation MESH:D007249
1679 47033-47046 Disease denotes HIV-1 Tat/HIV MESH:D015658
1705 43705-43708 Gene denotes MOR Gene:4988
1706 43710-43713 Gene denotes DOR Gene:58476
1707 43718-43721 Gene denotes KOR Gene:4986
1708 44126-44131 Gene denotes TNF-α Gene:7124
1709 44136-44141 Gene denotes IL-1β Gene:3552
1710 44362-44366 Gene denotes CCL5 Gene:6352
1711 44427-44431 Gene denotes CCL2 Gene:6347
1712 44596-44599 Gene denotes Tat Gene:6898
1713 44740-44749 Gene denotes NF-κB p65 Gene:5970
1714 44751-44755 Gene denotes RelA Gene:5970
1715 44795-44799 Gene denotes CCL2 Gene:6347
1716 44801-44805 Gene denotes CCL5 Gene:6352
1717 44811-44815 Gene denotes IL-6 Gene:3569
1718 44256-44261 Species denotes HIV-1 Tax:11676
1719 43540-43543 Species denotes HIV Tax:12721
1720 44177-44180 Species denotes HIV Tax:12721
1721 44181-44184 Gene denotes Tat Gene:6898
1722 44848-44852 Gene denotes Hage Gene:55510
1723 44684-44688 Gene denotes Hage Gene:55510
1724 44510-44514 Gene denotes Hage Gene:55510
1725 44204-44208 Gene denotes Hage Gene:55510
1726 44561-44569 Chemical denotes morphine MESH:D009020
1727 44635-44642 Chemical denotes calcium MESH:D002118
1728 44659-44663 Chemical denotes Ca2+ MESH:D000069285
1729 44270-44282 Disease denotes inflammation MESH:D007249
1731 47315-47318 Species denotes HIV Tax:12721
1760 47767-47770 Gene denotes Tat Gene:6898
1761 47893-47896 Gene denotes xCT Gene:23657
1762 47995-48000 Gene denotes TNF-α Gene:7124
1763 48045-48048 Gene denotes Tat Gene:6898
1764 48276-48280 Gene denotes TNFα Gene:7124
1765 48282-48286 Gene denotes IL-6 Gene:3569
1766 48292-48296 Gene denotes CCL2 Gene:6347
1767 48528-48531 Gene denotes MOR Gene:4988
1768 48602-48605 Gene denotes MOR Gene:4988
1769 48662-48665 Gene denotes MOR Gene:4988
1770 48955-48960 Gene denotes NF-κB Gene:4790
1771 47387-47390 Species denotes HIV Tax:12721
1772 48649-48652 Species denotes HIV Tax:12721
1773 47585-47600 Chemical denotes reactive oxygen
1774 47602-47605 Chemical denotes ROS
1775 47611-47619 Chemical denotes nitrogen MESH:D009584
1776 47621-47624 Chemical denotes RNS MESH:D026361
1777 47684-47693 Chemical denotes glutamate MESH:D018698
1778 47718-47721 Chemical denotes ATP MESH:D000255
1779 47805-47814 Chemical denotes glutamate MESH:D018698
1780 47859-47866 Chemical denotes cystine MESH:D003553
1781 47867-47876 Chemical denotes glutamate MESH:D018698
1782 48016-48024 Chemical denotes morphine MESH:D009020
1783 48185-48190 Chemical denotes MG115 MESH:C089486
1784 48214-48222 Chemical denotes morphine MESH:D009020
1785 48343-48346 Chemical denotes ROS
1786 48350-48353 Chemical denotes RNS MESH:D026361
1787 48762-48770 Chemical denotes morphine MESH:D009020
1791 49094-49097 Species denotes HIV Tax:12721
1792 49354-49366 Disease denotes inflammation MESH:D007249
1793 49371-49383 Disease denotes cytotoxicity MESH:D064420
1795 49424-49427 Species denotes HIV Tax:12721
1839 50949-50952 Gene denotes RyR Gene:6262
1840 50985-50988 Gene denotes Tat Gene:6898
1841 51552-51555 Gene denotes Tat Gene:6898
1842 51837-51840 Gene denotes MOR Gene:4988
1843 52278-52281 Gene denotes RyR Gene:6262
1844 52345-52348 Gene denotes MOR Gene:4988
1845 52126-52129 Gene denotes Tat Gene:6898
1846 51640-51643 Gene denotes Tat Gene:6898
1847 51502-51505 Gene denotes Tat Gene:6898
1848 51469-51472 Gene denotes Tat Gene:6898
1849 51314-51317 Gene denotes Tat Gene:6898
1850 51102-51105 Gene denotes Tat Gene:6898
1851 50910-50913 Gene denotes Tat Gene:6898
1852 51546-51551 Species denotes HIV-1 Tax:11676
1853 50906-50909 Species denotes HIV Tax:12721
1854 50858-50866 Chemical denotes Morphine MESH:D009020
1855 50928-50932 Chemical denotes Ca2+ MESH:D000069285
1856 50938-50947 Chemical denotes ryanodine MESH:D012433
1857 51011-51015 Chemical denotes Ca2+ MESH:D000069285
1858 51041-51050 Chemical denotes ryanodine MESH:D012433
1859 51060-51069 Chemical denotes ryanodine MESH:D012433
1860 51074-51082 Chemical denotes pyruvate MESH:D019289
1861 51110-51118 Chemical denotes morphine MESH:D009020
1862 51141-51145 Chemical denotes Ca2+ MESH:D000069285
1863 51149-51159 Chemical denotes Nimodipine MESH:D009553
1864 51168-51172 Chemical denotes Ca2+ MESH:D000069285
1865 51194-51204 Chemical denotes dantrolene MESH:D003620
1866 51244-51248 Chemical denotes Ca2+ MESH:D000069285
1867 51273-51282 Chemical denotes ryanodine MESH:D012433
1868 51322-51330 Chemical denotes morphine MESH:D009020
1869 51353-51357 Chemical denotes Ca2+ MESH:D000069285
1870 51395-51405 Chemical denotes nimodipine MESH:D009553
1871 51407-51417 Chemical denotes dantrolene MESH:D003620
1872 51422-51430 Chemical denotes pyruvate MESH:D019289
1873 51514-51522 Chemical denotes Morphine MESH:D009020
1874 51560-51568 Chemical denotes morphine MESH:D009020
1875 52095-52099 Chemical denotes Ca2+ MESH:D000069285
1876 52134-52142 Chemical denotes morphine MESH:D009020
1877 52203-52210 Chemical denotes calcium MESH:D002118
1878 52267-52276 Chemical denotes ryanodine MESH:D012433
1879 52316-52324 Chemical denotes morphine MESH:D009020
1880 52389-52393 Chemical denotes Ca2+ MESH:D000069285
1881 51581-51596 Disease denotes neuronal injury MESH:D009410
1910 49796-49799 Gene denotes Tat Gene:6898
1911 49838-49841 Gene denotes Tat Gene:6898
1912 49894-49897 Gene denotes MOR Gene:4988
1913 50165-50168 Gene denotes MOR Gene:18390
1914 50256-50259 Gene denotes MOR Gene:18390
1915 50290-50294 Gene denotes TLR4 Gene:21898
1916 50361-50364 Gene denotes Tat Gene:234724
1917 50450-50454 Gene denotes RyR2 Gene:6262
1918 50542-50545 Gene denotes MOR Gene:18390
1919 50668-50671 Gene denotes MOR Gene:18390
1920 49577-49580 Gene denotes Tat Gene:6898
1921 50269-50273 Species denotes mice Tax:10090
1922 49482-49485 Species denotes HIV Tax:12721
1923 49573-49576 Species denotes HIV Tax:12721
1924 49539-49547 Chemical denotes morphine MESH:D009020
1925 49783-49791 Chemical denotes morphine MESH:D009020
1926 49970-49974 Chemical denotes Ca2+ MESH:D000069285
1927 50008-50011 Chemical denotes ATP MESH:D000255
1928 50117-50125 Chemical denotes morphine MESH:D009020
1929 50219-50227 Chemical denotes morphine MESH:D009020
1930 50340-50348 Chemical denotes morphine MESH:D009020
1931 50422-50426 Chemical denotes Ca2+ MESH:D000069285
1932 50437-50446 Chemical denotes ryanodine MESH:D012433
1933 50514-50522 Chemical denotes morphine MESH:D009020
1934 50712-50716 Chemical denotes Ca2+ MESH:D000069285
1935 49494-49517 Disease denotes neurotoxicity via glial MESH:D020258
1936 49616-49632 Disease denotes dendritic injury MESH:D007635
1937 49850-49887 Disease denotes focal dendritic varicosities/swelling MESH:D014647
1953 53176-53181 Gene denotes TNF-α Gene:7124
1954 53186-53191 Gene denotes IL-1β Gene:3552
1955 53197-53201 Gene denotes TLR3 Gene:7098
1956 53236-53242 Gene denotes CX3CL1 Gene:6376
1957 53243-53254 Gene denotes fractalkine Gene:6376
1958 53258-53281 Gene denotes glucocorticoid receptor Gene:2908
1959 52792-52795 Species denotes HIV Tax:12721
1960 52974-52977 Species denotes HIV Tax:12721
1961 53008-53011 Species denotes HIV Tax:12721
1962 53118-53133 Chemical denotes methamphetamine MESH:D008694
1963 52523-52538 Disease denotes neuronal injury MESH:D009410
1964 52649-52657 Disease denotes infected MESH:D007239
1965 52719-52734 Disease denotes neuronal damage MESH:D009410
1966 52761-52776 Disease denotes Neuronal injury MESH:D009410
1967 52808-52816 Disease denotes infected MESH:D007239
1969 53384-53387 Species denotes HIV Tax:12721
1983 54938-54952 Gene denotes P-glycoprotein Gene:5243
1984 54954-54958 Gene denotes P-gp Gene:5243
1985 55027-55031 Gene denotes P-gp Gene:5243
1986 55203-55207 Gene denotes P-gp Gene:5243
1987 53493-53496 Species denotes HIV Tax:12721
1988 53538-53541 Species denotes HIV Tax:12721
1989 53788-53791 Species denotes HIV Tax:12721
1990 54676-54684 Chemical denotes morphine MESH:D009020
1991 54727-54735 Chemical denotes morphine MESH:D009020
1992 54850-54858 Chemical denotes morphine MESH:D009020
1993 54985-54993 Chemical denotes morphine MESH:D009020
1994 55282-55290 Chemical denotes morphine MESH:D009020
1995 53812-53824 Disease denotes HIV proteins MESH:D015658
2041 57174-57177 Gene denotes Tat Gene:234724
2042 57285-57288 Gene denotes Tat Gene:234724
2043 57314-57317 Gene denotes Tat Gene:234724
2044 57412-57415 Gene denotes Tat Gene:234724
2045 57680-57683 Gene denotes Tat Gene:234724
2046 57690-57693 Gene denotes Tat Gene:234724
2047 57872-57875 Gene denotes Tat Gene:234724
2048 57892-57895 Gene denotes Tat Gene:234724
2049 57912-57915 Gene denotes Tat Gene:234724
2050 57937-57940 Gene denotes Tat Gene:234724
2051 59056-59059 Gene denotes Tat Gene:234724
2052 59327-59330 Gene denotes Tat Gene:234724
2053 59347-59350 Gene denotes Tat Gene:234724
2054 59367-59370 Gene denotes Tat Gene:234724
2055 59392-59395 Gene denotes Tat Gene:234724
2056 57079-57082 Gene denotes Tat Gene:6898
2057 57352-57355 Gene denotes Tat Gene:234724
2058 57073-57078 Species denotes HIV-1 Tax:11676
2059 57328-57332 Species denotes mice Tax:10090
2060 57358-57363 Species denotes mouse Tax:10090
2061 57426-57430 Species denotes mice Tax:10090
2062 57951-57955 Species denotes mice Tax:10090
2063 57999-58010 Species denotes horseradish Tax:3704
2064 58482-58486 Species denotes mice Tax:10090
2065 58908-58912 Species denotes mice Tax:10090
2066 59406-59410 Species denotes mice Tax:10090
2067 57087-57095 Chemical denotes morphine MESH:D009020
2068 57388-57396 Chemical denotes morphine MESH:D009020
2069 57487-57495 Chemical denotes morphine MESH:D009020
2070 57623-57631 Chemical denotes morphine MESH:D009020
2071 57721-57729 Chemical denotes morphine MESH:D009020
2072 57779-57787 Chemical denotes morphine MESH:D009020
2073 57917-57925 Chemical denotes morphine MESH:D009020
2074 57942-57950 Chemical denotes morphine MESH:D009020
2075 57971-57979 Chemical denotes morphine MESH:D009020
2076 58239-58252 Chemical denotes Hoechst 33342 MESH:C017807
2077 58465-58473 Chemical denotes morphine MESH:D009020
2078 59070-59078 Chemical denotes morphine MESH:D009020
2079 59115-59127 Chemical denotes dolutegravir MESH:C562325
2080 59136-59144 Chemical denotes abacavir MESH:C106538
2081 59158-59168 Chemical denotes lamivudine MESH:D019259
2082 59248-59256 Chemical denotes morphine MESH:D009020
2083 59372-59380 Chemical denotes morphine MESH:D009020
2084 59397-59405 Chemical denotes morphine MESH:D009020
2085 57103-57112 Disease denotes leakiness MESH:C535298
2121 55677-55680 Gene denotes Tat Gene:6898
2122 55714-55719 Gene denotes TNF-α Gene:7124
2123 55724-55728 Gene denotes IL-8 Gene:3576
2124 55814-55817 Gene denotes Tat Gene:6898
2125 55838-55841 Gene denotes Tat Gene:6898
2126 55880-55885 Gene denotes JAM-2 Gene:58494
2127 55913-55917 Gene denotes ZO-1 Gene:7082
2128 55959-55962 Gene denotes Tat Gene:6898
2129 55981-55989 Gene denotes occludin Gene:100506658
2130 56046-56049 Gene denotes Tat Gene:6898
2131 56174-56177 Gene denotes Tat Gene:6898
2132 56286-56289 Gene denotes Tat Gene:6898
2133 56672-56676 Gene denotes P-gp Gene:5243
2134 56904-56908 Gene denotes P-gp Gene:5243
2135 56093-56096 Gene denotes Tat Gene:234724
2136 55498-55503 Species denotes human Tax:9606
2137 55671-55676 Species denotes HIV-1 Tax:11676
2138 56108-56113 Species denotes mouse Tax:10090
2139 56168-56173 Species denotes HIV-1 Tax:11676
2140 56097-56107 Species denotes transgenic Tax:10090
2141 55658-55666 Chemical denotes morphine MESH:D009020
2142 55802-55810 Chemical denotes morphine MESH:D009020
2143 55825-55833 Chemical denotes Morphine MESH:D009020
2144 55944-55952 Chemical denotes morphine MESH:D009020
2145 56023-56031 Chemical denotes morphine MESH:D009020
2146 56182-56190 Chemical denotes morphine MESH:D009020
2147 56253-56261 Chemical denotes morphine MESH:D009020
2148 56347-56355 Chemical denotes dextrans MESH:D003911
2149 56431-56439 Chemical denotes Morphine MESH:D009020
2150 56565-56573 Chemical denotes Morphine MESH:D009020
2151 56710-56718 Chemical denotes morphine MESH:D009020
2152 56803-56811 Chemical denotes morphine MESH:D009020
2153 56963-56971 Chemical denotes morphine MESH:D009020
2154 55761-55770 Disease denotes tightness MESH:C536920
2155 56485-56489 Disease denotes ARVs
2183 59855-59858 Gene denotes Tat Gene:6898
2184 60162-60165 Gene denotes Tat Gene:6898
2185 60200-60203 Gene denotes Tat Gene:6898
2186 60287-60291 Gene denotes CCL2 Gene:6347
2187 60296-60300 Gene denotes CCL5 Gene:6352
2188 60370-60373 Gene denotes MOR Gene:4988
2189 60422-60425 Gene denotes Tat Gene:6898
2190 60520-60524 Gene denotes CCL5 Gene:6352
2191 60651-60654 Gene denotes Tat Gene:234724
2192 60741-60745 Gene denotes TLR2 Gene:24088
2193 60750-60754 Gene denotes TLR4 Gene:21898
2194 60387-60391 Gene denotes Hage Gene:55510
2195 60194-60199 Species denotes HIV-1 Tax:11676
2196 60606-60619 Species denotes S. pneumoniae Tax:1313
2197 60629-60633 Species denotes mice Tax:10090
2198 59485-59488 Species denotes HIV Tax:12721
2199 59850-59853 Species denotes HIV Tax:12721
2200 60158-60161 Species denotes HIV Tax:12721
2201 59863-59871 Chemical denotes morphine MESH:D009020
2202 60208-60216 Chemical denotes morphine MESH:D009020
2203 60430-60438 Chemical denotes morphine MESH:D009020
2204 60442-60455 Chemical denotes buprenorphine MESH:D002047
2205 60635-60643 Chemical denotes morphine MESH:D009020
2206 59490-59510 Disease denotes HIV-1 viral proteins
2207 59679-59687 Disease denotes infected MESH:D007239
2209 60620-60628 Disease denotes infected MESH:D007239
2217 61832-61846 Gene denotes P-glycoprotein Gene:5243
2218 61848-61852 Gene denotes P-gp Gene:5243
2219 62234-62238 Gene denotes P-gp Gene:5243
2220 62255-62287 Gene denotes breast cancer resistance protein Gene:9429
2221 62289-62293 Gene denotes Bcrp Gene:9429
2222 61976-61979 Species denotes HIV Tax:12721
2223 62447-62450 Species denotes HIV Tax:12721
2228 61079-61082 Gene denotes MDM Gene:57152
2229 60809-60812 Species denotes HIV Tax:12721
2230 61136-61144 Disease denotes infected MESH:D007239
2231 61378-61391 Disease denotes HIV infection MESH:D015658
2251 63478-63481 Gene denotes Tat Gene:234724
2252 63483-63488 Gene denotes gp120 Gene:3700
2253 63494-63497 Gene denotes Nef Gene:6285
2254 63751-63754 Gene denotes Tat Gene:6898
2255 63214-63217 Gene denotes SIV Gene:8114
2256 63182-63211 Species denotes simian immunodeficiency virus Tax:11723
2257 63229-63244 Species denotes rhesus macaques Tax:9544
2258 63295-63299 Species denotes mice Tax:10090
2259 63802-63810 Species denotes patients Tax:9606
2260 62516-62519 Species denotes HIV Tax:12721
2261 62530-62549 Disease denotes white matter damage MESH:D056784
2262 62772-62791 Disease denotes white matter damage MESH:D056784
2263 62892-62913 Disease denotes White matter deficits MESH:D056784
2264 62934-62954 Disease denotes cognitive impairment MESH:D003072
2265 63117-63127 Disease denotes depression MESH:D000275
2266 63220-63228 Disease denotes infected MESH:D007239
2267 63272-63284 Disease denotes HIV-infected MESH:D015658
2268 63523-63532 Disease denotes OL injury MESH:C564538
2269 63797-63801 Disease denotes AIDS MESH:D000163
2293 63910-63913 Gene denotes CD4 Gene:920
2294 64491-64494 Gene denotes Tat Gene:6898
2295 64720-64725 Gene denotes Kv1.3 Gene:3738
2296 64958-64961 Gene denotes Tat Gene:6898
2297 64994-64997 Gene denotes Tat Gene:6898
2298 65025-65031 Gene denotes GSK-3β Gene:2931
2299 64236-64240 Gene denotes Nath Gene:80155
2300 64798-64801 Gene denotes Tat Gene:6898
2301 64485-64490 Species denotes HIV-1 Tax:11676
2302 63836-63839 Species denotes HIV Tax:12721
2303 63946-63949 Species denotes HIV Tax:12721
2304 64201-64211 Chemical denotes virotoxins MESH:C026460
2305 64543-64595 Chemical denotes α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid MESH:D018350
2306 64597-64601 Chemical denotes AMPA MESH:D018350
2307 64603-64627 Chemical denotes N-methyl-D-aspartic acid MESH:D016202
2308 64629-64633 Chemical denotes NMDA MESH:D016202
2309 63933-63942 Disease denotes infection MESH:D007239
2310 63964-63969 Disease denotes Esiri
2311 64039-64052 Disease denotes HIV infection MESH:D015658
2312 64096-64115 Disease denotes white matter damage MESH:D056784
2313 64250-64258 Disease denotes infected MESH:D007239
2314 64384-64388 Disease denotes ARVs
2315 64408-64423 Disease denotes OL cytotoxicity MESH:D064420
2327 65580-65600 Gene denotes myelin basic protein Gene:24547
2328 65640-65667 Gene denotes amyloid-β precursor protein Gene:54226
2329 66154-66157 Gene denotes KOR Gene:4986
2330 66137-66140 Gene denotes MOR Gene:4988
2331 65498-65502 Species denotes rats Tax:10116
2332 65476-65485 Chemical denotes oxycodone MESH:D010098
2333 65155-65167 Disease denotes Opioid abuse MESH:D009293
2334 65192-65205 Disease denotes demyelination MESH:D003711
2335 65207-65226 Disease denotes leukoencephalopathy MESH:D056784
2336 65429-65446 Disease denotes opiate dependence MESH:D009293
2337 65515-65527 Disease denotes axonopathies MESH:D016472
2358 67064-67067 Gene denotes Tat Gene:234724
2359 67114-67123 Gene denotes caspase-3 Gene:12367
2360 67265-67268 Gene denotes MOR Gene:4988
2361 67384-67387 Gene denotes MOR Gene:4988
2362 66760-66763 Gene denotes SIV Gene:8114
2363 66628-66643 Species denotes rhesus macaques Tax:9544
2364 67069-67073 Species denotes mice Tax:10090
2365 67424-67427 Species denotes HIV Tax:12721
2366 66669-66677 Chemical denotes morphine MESH:D009020
2367 66743-66751 Chemical denotes morphine MESH:D009020
2368 67013-67021 Chemical denotes Morphine MESH:D009020
2369 67181-67189 Chemical denotes naloxone MESH:D009270
2370 67193-67203 Chemical denotes naltrexone MESH:D009271
2371 66302-66321 Disease denotes white matter damage MESH:D056784
2372 66339-66348 Disease denotes infection MESH:D007239
2373 66586-66599 Disease denotes demyelination MESH:D003711
2374 66615-66627 Disease denotes SIV-infected MESH:D012857
2375 66803-66825 Disease denotes dysmyelinating lesions MESH:C563789
2376 66873-66884 Disease denotes myelin loss MESH:D020279
2377 66933-66940 Disease denotes gliosis MESH:D005911
2379 67468-67471 Species denotes HIV Tax:12721
2388 68464-68469 Species denotes human Tax:9606
2389 68457-68460 Species denotes HIV Tax:12721
2390 68550-68558 Chemical denotes morphine MESH:D009020
2391 67820-67840 Disease denotes harbor HIV infection MESH:D015658
2392 67949-67958 Disease denotes infection MESH:D007239
2393 68151-68163 Disease denotes HIV-infected MESH:D015658
2394 68525-68546 Disease denotes HIVBaL-infected hNPCs MESH:D007239
2395 68620-68636 Disease denotes HIVBaL infection MESH:D007239
2414 68796-68801 Gene denotes gp120 Gene:3700
2415 69292-69297 Gene denotes gp120 Gene:3700
2416 69527-69558 Gene denotes MAPK-activated protein kinase 2 Gene:9261
2417 69563-69569 Gene denotes Cdc25B Gene:994
2418 69675-69679 Gene denotes BDNF Gene:627
2419 70007-70013 Gene denotes ERK1/2 Gene:5595
2420 70023-70026 Gene denotes p53 Gene:7157
2421 70032-70035 Gene denotes p21 Gene:644914
2422 70064-70073 Gene denotes cyclin D1 Gene:595
2423 69346-69350 Gene denotes Tran Gene:7154
2424 68712-68715 Species denotes HIV Tax:12721
2425 68789-68792 Species denotes HIV Tax:12721
2426 69080-69083 Species denotes HIV Tax:12721
2427 69284-69287 Species denotes HIV Tax:12721
2428 69715-69718 Species denotes HIV Tax:12721
2429 69909-69912 Species denotes HIV Tax:12721
2430 70406-70409 Species denotes HIV Tax:12721
2431 69323-69341 Gene denotes chemokine receptor Gene:7852
2467 70635-70639 Gene denotes Tat1 Gene:116369
2468 70679-70682 Gene denotes MOR Gene:4988
2469 70780-70789 Gene denotes caspase-3 Gene:836
2470 70875-70878 Gene denotes Tat Gene:6898
2471 70992-70995 Gene denotes Tat Gene:6898
2472 71123-71126 Gene denotes Tat Gene:6898
2473 71409-71412 Gene denotes Tat Gene:6898
2474 71622-71625 Gene denotes Tat Gene:6898
2475 71671-71675 Gene denotes Sox2 Gene:6657
2476 71681-71686 Gene denotes Olig2 Gene:10215
2477 72366-72370 Gene denotes CCR5 Gene:1234
2478 72462-72465 Gene denotes Tat Gene:6898
2479 72493-72499 Gene denotes ERK1/2 Gene:5595
2480 72523-72526 Gene denotes p53 Gene:7157
2481 72531-72534 Gene denotes p21 Gene:644914
2482 71306-71311 Species denotes human Tax:9606
2483 71548-71553 Species denotes HIV-1 Tax:11676
2484 71823-71828 Species denotes human Tax:9606
2485 72754-72759 Species denotes human Tax:9606
2486 71629-71632 Species denotes HIV Tax:12721
2487 72700-72703 Species denotes HIV Tax:12721
2488 70613-70621 Chemical denotes morphine MESH:D009020
2489 70863-70871 Chemical denotes morphine MESH:D009020
2490 71000-71008 Chemical denotes morphine MESH:D009020
2491 71348-71356 Chemical denotes morphine MESH:D009020
2492 72054-72062 Chemical denotes morphine MESH:D009020
2493 72190-72199 Chemical denotes maraviroc MESH:D000077592
2494 72449-72457 Chemical denotes morphine MESH:D009020
2495 72666-72674 Chemical denotes morphine MESH:D009020
2496 70567-70583 Disease denotes HIV/HIV proteins MESH:D015658
2497 71157-71162 Disease denotes death MESH:D003643
2498 71450-71474 Disease denotes HIV-1SF162-infected MDMs MESH:D015658
2499 71872-71881 Disease denotes infection MESH:D007239
2500 71897-71903 Disease denotes HIVBaL
2501 72281-72304 Disease denotes R5-tropic HIV infection MESH:D015658
2503 72908-72911 Species denotes HIV Tax:12721
2509 73224-73227 Gene denotes Eap Gene:2028
2510 73107-73110 Gene denotes Rao Gene:314
2511 73128-73133 Species denotes human Tax:9606
2512 73085-73088 Species denotes HIV Tax:12721
2513 73521-73524 Species denotes HIV Tax:12721
2515 73539-73544 Species denotes HIV-1 Tax:11676
2540 74732-74735 Gene denotes Tat Gene:6898
2541 74809-74812 Gene denotes Tat Gene:6898
2542 74936-74940 Gene denotes IL-6 Gene:3569
2543 74945-74950 Gene denotes TNF-α Gene:7124
2544 75294-75299 Gene denotes gp120 Gene:3700
2545 75365-75370 Gene denotes gp120 Gene:3700
2546 75043-75046 Gene denotes Rao Gene:237940
2547 74659-74662 Gene denotes Rao Gene:237940
2548 74580-74583 Gene denotes Rao Gene:237940
2549 74393-74396 Gene denotes Rao Gene:237940
2551 73580-73585 Species denotes HIV-1 Tax:11676
2552 74256-74260 Species denotes mice Tax:10090
2553 74268-74272 Species denotes mice Tax:10090
2554 73624-73627 Species denotes HIV Tax:12721
2555 73836-73839 Species denotes HIV Tax:12721
2556 75212-75214 Gene denotes A2 Gene:170589
2557 74441-74444 Gene denotes Tat Gene:6898
2558 75175-75191 Chemical denotes prostaglandin E2 MESH:D015232
2559 74163-74177 Disease denotes C HIV-infected MESH:D015658
2560 74240-74255 Disease denotes immunodeficient MESH:D007153
2561 74262-74266 Disease denotes SCID MESH:D053632
2562 74323-74338 Disease denotes memory deficits MESH:D008569
2563 74359-74391 Disease denotes astrogliosis and neuronal damage MESH:D009410
2571 75622-75625 Gene denotes Tat Gene:6898
2572 75528-75531 Species denotes HIV Tax:12721
2573 75737-75740 Species denotes HIV Tax:12721
2574 75839-75842 Species denotes HIV Tax:12721
2575 75981-75984 Species denotes HIV Tax:12721
2576 75587-75595 Disease denotes toxicity MESH:D064420
2577 75860-75874 Disease denotes HIV-1 infected MESH:D015658
2591 76164-76169 Gene denotes gp120 Gene:3700
2592 76540-76544 Gene denotes Hage Gene:55510
2593 76216-76220 Gene denotes Hage Gene:55510
2594 76376-76381 Species denotes HIV-1 Tax:11676
2595 76399-76404 Species denotes human Tax:9606
2596 76488-76493 Species denotes HIV-1 Tax:11676
2597 76009-76012 Species denotes HIV Tax:12721
2598 76092-76100 Chemical denotes Morphine MESH:D009020
2599 76339-76347 Chemical denotes morphine MESH:D009020
2600 76527-76535 Chemical denotes morphine MESH:D009020
2601 76047-76058 Disease denotes HIV tropism MESH:D015658
2602 76405-76413 Disease denotes hepatoma MESH:D006528
2603 76414-76422 CellLine denotes Huh7.5.1 CVCL:E049
2607 76774-76779 Species denotes HIV-1 Tax:11676
2608 76657-76660 Species denotes HIV Tax:12721
2609 76876-76886 Disease denotes neurotoxic MESH:D020258
2625 77129-77133 Gene denotes CCR5 Gene:1234
2626 77245-77249 Gene denotes CCR5 Gene:1234
2627 77302-77306 Gene denotes CCR5 Gene:1234
2628 77523-77527 Gene denotes CCR5 Gene:1234
2629 77655-77659 Gene denotes CCR2 Gene:729230
2631 77755-77761 Gene denotes CXCL12 Gene:6387
2632 77018-77021 Species denotes HIV Tax:12721
2633 77138-77141 Species denotes HIV Tax:12721
2634 77321-77324 Species denotes HIV Tax:12721
2635 77628-77631 Species denotes HIV Tax:12721
2636 77847-77850 Species denotes HIV Tax:12721
2637 77289-77298 Disease denotes infection MESH:D007239
2638 77415-77424 Disease denotes infection MESH:D007239
2669 78028-78033 Gene denotes OPRM1 Gene:4988
2670 78038-78043 Gene denotes OPRK1 Gene:4986
2671 78067-78071 Gene denotes DRD1 Gene:1812
2672 78076-78080 Gene denotes DRD2 Gene:1813
2673 78180-78183 Gene denotes CD4 Gene:920
2674 78487-78490 Gene denotes MOR Gene:4988
2675 78618-78621 Gene denotes MOR Gene:4988
2676 78694-78697 Gene denotes MOR Gene:4988
2677 78787-78792 Gene denotes OPRM1 Gene:4988
2678 78959-78964 Gene denotes OPRM1 Gene:4988
2679 79356-79361 Gene denotes OPRM1 Gene:4988
2680 79429-79434 Gene denotes TNF-α Gene:7124
2681 79436-79441 Gene denotes IL-10 Gene:3586
2682 79443-79448 Gene denotes IFN-γ Gene:3458
2683 79558-79561 Gene denotes MOR Gene:4988
2684 79577-79582 Gene denotes OPRM1 Gene:4988
2685 78949-78954 Species denotes women Tax:9606
2686 79621-79626 Species denotes HIV-1 Tax:11676
2687 78147-78150 Species denotes HIV Tax:12721
2688 78503-78506 Species denotes HIV Tax:12721
2689 78636-78639 Species denotes HIV Tax:12721
2690 78710-78713 Species denotes HIV Tax:12721
2691 78863-78866 Species denotes HIV Tax:12721
2692 79040-79043 Species denotes HIV Tax:12721
2693 78361-78373 Disease denotes opiate abuse MESH:D009293
2694 78934-78948 Disease denotes HIV-1-infected MESH:D015658
2695 79161-79176 Disease denotes drug metabolism MESH:D065606
2696 79318-79333 Disease denotes drug dependence MESH:D019966
2697 79339-79344 Mutation denotes A118G rs1799971
2708 79647-79652 Gene denotes OPRM1 Gene:4988
2709 79757-79762 Gene denotes OPRM1 Gene:4988
2710 80215-80218 Gene denotes MOR Gene:4988
2711 80383-80388 Gene denotes MOR-1 Gene:18390
2712 79693-79699 Species denotes humans Tax:9606
2713 80209-80214 Species denotes human Tax:9606
2714 80477-80482 Species denotes human Tax:9606
2715 80322-80325 Species denotes HIV Tax:12721
2716 79821-79836 Disease denotes HIV-1 infection MESH:D015658
2717 80559-80579 Disease denotes cognitive impairment MESH:D003072
2722 80608-80611 Gene denotes MOR Gene:4988
2723 80616-80634 Gene denotes Chemokine Receptor Gene:7852
2724 80649-80653 Gene denotes CCR5 Gene:1234
2725 80655-80660 Gene denotes CXCR4 Gene:7852
2763 80864-80867 Gene denotes MOR Gene:4988
2764 80872-80876 Gene denotes CCR5 Gene:1234
2765 80880-80885 Gene denotes CXCR4 Gene:7852
2766 81307-81310 Gene denotes MOR Gene:4988
2767 81315-81318 Gene denotes DOR Gene:58476
2768 81361-81365 Gene denotes CCR5 Gene:1234
2769 81384-81388 Gene denotes CCL3 Gene:6348
2770 81390-81394 Gene denotes CCL4 Gene:6351
2771 81400-81404 Gene denotes CCL5 Gene:6352
2772 81529-81532 Gene denotes MOR Gene:4988
2773 81543-81547 Gene denotes PKCζ Gene:5590
2774 81563-81567 Gene denotes CCR5 Gene:1234
2775 81638-81641 Gene denotes MOR Gene:4988
2776 81668-81672 Gene denotes CCL2 Gene:6347
2777 81677-81681 Gene denotes CCL4 Gene:6351
2778 81758-81763 Gene denotes CCR2b Gene:729230
2779 81765-81769 Gene denotes CCR3 Gene:1232
2780 81775-81779 Gene denotes CCR5 Gene:1234
2781 81857-81861 Gene denotes CCR5 Gene:1234
2782 81866-81871 Gene denotes CXCR4 Gene:7852
2783 81886-81890 Gene denotes CD14 Gene:929
2784 81955-81958 Gene denotes MOR Gene:4988
2785 82075-82080 Gene denotes CXCR4 Gene:7852
2786 82146-82149 Gene denotes MOR Gene:4988
2787 82176-82179 Gene denotes KOR Gene:4986
2788 82276-82279 Gene denotes KOR Gene:4986
2789 82283-82288 Gene denotes CXCR4 Gene:7852
2790 82451-82469 Gene denotes chemokine receptor Gene:7852
2791 82045-82048 Species denotes HIV Tax:12721
2792 82428-82431 Species denotes HIV Tax:12721
2793 82529-82532 Species denotes HIV Tax:12721
2794 81190-81208 Gene denotes chemokine receptor Gene:7852
2795 81915-81923 Chemical denotes N-MePhe4
2796 81925-81943 Chemical denotes Gly-ol]-enkephalin
2797 82186-82190 Chemical denotes Ca2+ MESH:D000069285
2798 80697-80710 Disease denotes HIV infection MESH:D015658
2799 80715-80736 Disease denotes HIV neuropathogenesis MESH:D015658
2825 82626-82630 Gene denotes CCR5 Gene:1234
2826 82816-82819 Gene denotes MOR Gene:4988
2827 82840-82844 Gene denotes CCR5 Gene:1234
2828 82885-82889 Gene denotes CCR3 Gene:1232
2829 82894-82899 Gene denotes CXCR2 Gene:3579
2830 82970-82974 Gene denotes IL-8 Gene:3576
2831 82976-82980 Gene denotes CCL4 Gene:6351
2832 83031-83035 Gene denotes CCR5 Gene:12774
2833 83101-83105 Gene denotes CCL2 Gene:20296
2834 83126-83129 Gene denotes Tat Gene:234724
2835 83212-83216 Gene denotes CCL2 Gene:20296
2836 83257-83261 Gene denotes CCL5 Gene:20304
2837 83365-83369 Gene denotes CCL5 Gene:20304
2838 83380-83383 Gene denotes Tat Gene:234724
2839 83418-83422 Gene denotes CCL2 Gene:20296
2840 83278-83281 Gene denotes Tat Gene:234724
2841 83463-83467 Gene denotes Hage Gene:55510
2842 83150-83154 Gene denotes Hage Gene:55510
2843 82860-82865 Species denotes HIV-1 Tax:11676
2844 82941-82946 Species denotes HIV-1 Tax:11676
2845 83130-83145 Species denotes transgenic mice Tax:10090
2846 83267-83271 Species denotes mice Tax:10090
2847 83061-83069 Chemical denotes morphine MESH:D009020
2848 83286-83294 Chemical denotes morphine MESH:D009020
2849 83388-83396 Chemical denotes morphine MESH:D009020
2881 84904-84908 Gene denotes CCR5 Gene:1234
2882 84909-84912 Gene denotes MOR Gene:4988
2883 85014-85017 Gene denotes MOR Gene:4988
2884 85018-85022 Gene denotes CCR5 Gene:1234
2885 85128-85131 Gene denotes MOR Gene:4988
2886 85164-85168 Gene denotes CCR5 Gene:1234
2887 85396-85399 Gene denotes MOR Gene:4988
2888 85404-85408 Gene denotes CCR5 Gene:1234
2889 85556-85559 Gene denotes Tat Gene:6898
2890 86056-86059 Gene denotes MOR Gene:4988
2891 86064-86068 Gene denotes CCR5 Gene:1234
2892 86590-86594 Gene denotes Hage Gene:55510
2893 86149-86153 Gene denotes Hage Gene:55510
2894 84848-84853 Species denotes HIV-1 Tax:11676
2895 84865-84870 Species denotes human Tax:9606
2896 86319-86324 Species denotes HIV-1 Tax:11676
2897 85814-85817 Species denotes HIV Tax:12721
2898 85923-85926 Species denotes HIV Tax:12721
2899 86112-86115 Species denotes HIV Tax:12721
2900 84982-84990 Chemical denotes morphine MESH:D009020
2901 85263-85271 Chemical denotes triazole MESH:D014230
2902 85719-85727 Chemical denotes morphine MESH:D009020
2903 85773-85782 Chemical denotes maraviroc MESH:D000077592
2904 85854-85862 Chemical denotes morphine MESH:D009020
2905 85971-85979 Chemical denotes morphine MESH:D009020
2906 86123-86131 Chemical denotes morphine MESH:D009020
2907 86345-86353 Chemical denotes morphine MESH:D009020
2908 86452-86462 Chemical denotes naltrexone MESH:D009271
2909 85446-85461 Disease denotes HIV-1 infection MESH:D015658
2910 86257-86266 Disease denotes infection MESH:D007239
2911 86286-86294 Disease denotes infected MESH:D007239
2937 83536-83540 Gene denotes CCR5 Gene:1234
2938 83545-83548 Gene denotes MOR Gene:4988
2939 84220-84223 Gene denotes MOR Gene:4988
2940 84228-84232 Gene denotes CCR5 Gene:1234
2941 84275-84278 Gene denotes MOR Gene:4988
2942 84283-84287 Gene denotes CCR5 Gene:1234
2943 84460-84464 Gene denotes CCR5 Gene:1234
2944 84508-84511 Gene denotes MOR Gene:4988
2945 84678-84681 Gene denotes MOR Gene:4988
2946 84686-84690 Gene denotes CCR5 Gene:1234
2947 84757-84761 Gene denotes Hage Gene:55510
2948 84520-84524 Gene denotes Hage Gene:55510
2949 83738-83742 Gene denotes Hage Gene:55510
2950 83662-83667 Species denotes HIV-1 Tax:11676
2951 84033-84036 Species denotes HIV Tax:12721
2952 84112-84115 Species denotes HIV Tax:12721
2953 84425-84428 Species denotes HIV Tax:12721
2954 84723-84726 Species denotes HIV Tax:12721
2955 83645-83655 Chemical denotes naltrexone MESH:D009271
2956 83781-83790 Chemical denotes maraviroc MESH:D000077592
2957 83872-83880 Chemical denotes morphine MESH:D009020
2958 83908-83917 Chemical denotes maraviroc MESH:D000077592
2959 84073-84081 Chemical denotes morphine MESH:D009020
2960 84131-84139 Chemical denotes morphine MESH:D009020
2961 84436-84444 Chemical denotes morphine MESH:D009020
2985 86627-86631 Gene denotes CCR5 Gene:1234
2986 86727-86730 Gene denotes MOR Gene:4988
2987 86812-86816 Gene denotes CCR5 Gene:1234
2988 86877-86880 Gene denotes Tat Gene:6898
2989 87067-87070 Gene denotes Tat Gene:6898
2990 87129-87133 Gene denotes CCR5 Gene:1234
2991 87155-87158 Gene denotes MOR Gene:4988
2992 87287-87291 Gene denotes CCR5 Gene:1234
2993 87368-87371 Gene denotes Tat Gene:6898
2994 87456-87460 Gene denotes BDNF Gene:627
2995 87250-87253 Gene denotes Tat Gene:6898
2996 86708-86716 Chemical denotes morphine MESH:D009020
2997 86885-86893 Chemical denotes morphine MESH:D009020
2998 86958-86967 Chemical denotes maraviroc MESH:D000077592
2999 87050-87054 Chemical denotes Ca2+ MESH:D000069285
3000 87073-87081 Chemical denotes morphine MESH:D009020
3001 87217-87225 Chemical denotes morphine MESH:D009020
3002 87356-87364 Chemical denotes morphine MESH:D009020
3003 86686-86696 Disease denotes neurotoxic MESH:D020258
3004 86856-86869 Disease denotes neurotoxicity MESH:D020258
3005 86998-87011 Disease denotes neurotoxicity MESH:D020258
3006 87254-87267 Disease denotes neurotoxicity MESH:D020258
3007 87372-87380 Disease denotes toxicity MESH:D064420
3011 87522-87526 Gene denotes BDNF Gene:627
3012 87528-87533 Gene denotes mBDNF Gene:12064
3013 87547-87551 Gene denotes CCR5 Gene:1234
3108 88476-88480 Gene denotes CCR5 Gene:1234
3109 88485-88489 Gene denotes BDNF Gene:627
3110 88616-88647 Gene denotes glial fibrillary acidic protein Gene:2670
3111 88649-88653 Gene denotes GFAP Gene:2670
3112 88718-88735 Gene denotes μ-opioid receptor Gene:4988
3113 88737-88740 Gene denotes MOR Gene:4988
3114 88750-88754 Gene denotes CCR5 Gene:1234
3115 88892-88895 Gene denotes Tat Gene:6898
3116 88942-88946 Gene denotes CCR5 Gene:1234
3117 89007-89010 Gene denotes MSN Gene:4478
3118 89024-89027 Gene denotes Tat Gene:6898
3119 89106-89109 Gene denotes Tat Gene:6898
3120 89186-89189 Gene denotes Tat Gene:6898
3121 89372-89375 Gene denotes Tat Gene:6898
3122 89600-89603 Gene denotes Tat Gene:6898
3123 89783-89786 Gene denotes MOR Gene:4988
3124 90039-90043 Gene denotes CCR5 Gene:1234
3125 90074-90078 Gene denotes CCR5 Gene:1234
3126 90110-90114 Gene denotes CCR5 Gene:1234
3127 90164-90168 Gene denotes BDNF Gene:627
3128 90184-90188 Gene denotes BDNF Gene:627
3129 90237-90241 Gene denotes BDNF Gene:627
3130 90288-90293 Gene denotes mBDNF Gene:12064
3131 90364-90369 Gene denotes mBDNF Gene:12064
3132 90378-90382 Gene denotes BDNF Gene:627
3133 90482-90485 Gene denotes Tat Gene:6898
3134 90529-90533 Gene denotes BDNF Gene:627
3135 90538-90543 Gene denotes mBDNF Gene:12064
3136 90574-90578 Gene denotes BDNF Gene:627
3137 90579-90584 Gene denotes mBDNF Gene:12064
3138 90642-90646 Gene denotes CCR5 Gene:1234
3139 90764-90768 Gene denotes BDNF Gene:627
3140 90861-90865 Gene denotes BDNF Gene:627
3141 90866-90871 Gene denotes mBDNF Gene:12064
3142 90992-90996 Gene denotes BDNF Gene:627
3143 90997-91002 Gene denotes mBDNF Gene:12064
3144 91144-91148 Gene denotes CCR5 Gene:1234
3145 91170-91175 Gene denotes mBDNF Gene:12064
3146 91212-91215 Gene denotes Tat Gene:6898
3147 91267-91270 Gene denotes MSN Gene:4478
3148 91311-91314 Gene denotes Tat Gene:6898
3149 91386-91389 Gene denotes Tat Gene:6898
3150 91428-91431 Gene denotes Tat Gene:6898
3151 91523-91528 Gene denotes mBDNF Gene:12064
3152 91584-91587 Gene denotes Tat Gene:6898
3153 91683-91686 Gene denotes Tat Gene:6898
3154 91769-91773 Gene denotes CCR5 Gene:1234
3155 91883-91886 Gene denotes MOR Gene:4988
3156 91901-91905 Gene denotes CCR5 Gene:1234
3157 91919-91922 Gene denotes MOR Gene:4988
3158 91934-91938 Gene denotes BDNF Gene:627
3159 91301-91306 Gene denotes mBDNF Gene:12064
3160 90201-90206 Gene denotes mBDNF Gene:12064
3161 89615-89618 Gene denotes MSN Gene:4478
3162 91328-91331 Gene denotes Tat Gene:6898
3163 90943-90946 Gene denotes Tat Gene:6898
3164 89690-89693 Gene denotes Tat Gene:6898
3165 88509-88512 Gene denotes Tat Gene:6898
3166 88503-88508 Species denotes HIV-1 Tax:11676
3167 88886-88891 Species denotes HIV-1 Tax:11676
3168 91787-91792 Species denotes HIV-1 Tax:11676
3169 88517-88525 Chemical denotes morphine MESH:D009020
3170 88900-88908 Chemical denotes morphine MESH:D009020
3171 89088-89096 Chemical denotes morphine MESH:D009020
3172 89210-89218 Chemical denotes naloxone MESH:D009270
3173 89224-89232 Chemical denotes Naloxone MESH:D009270
3174 89236-89244 Chemical denotes morphine MESH:D009020
3175 89486-89494 Chemical denotes morphine MESH:D009020
3176 89538-89546 Chemical denotes morphine MESH:D009020
3177 89666-89674 Chemical denotes naloxone MESH:D009270
3178 89758-89766 Chemical denotes morphine MESH:D009020
3179 90488-90496 Chemical denotes morphine MESH:D009020
3180 90727-90735 Chemical denotes morphine MESH:D009020
3181 90951-90959 Chemical denotes morphine MESH:D009020
3182 91220-91228 Chemical denotes morphine MESH:D009020
3183 91336-91344 Chemical denotes morphine MESH:D009020
3184 91482-91490 Chemical denotes morphine MESH:D009020
3185 91592-91600 Chemical denotes morphine MESH:D009020
3186 88546-88558 Disease denotes cytotoxicity MESH:D064420
3187 89031-89041 Disease denotes neurotoxic MESH:D020258
3188 89118-89126 Disease denotes toxicity MESH:D064420
3189 89319-89336 Disease denotes CCR5-deficit glia MESH:D009461
3190 89458-89466 Disease denotes toxicity MESH:D064420
3191 89694-89702 Disease denotes toxicity MESH:D064420
3192 89860-89870 Disease denotes neurotoxic MESH:D020258
3193 89888-89907 Disease denotes CCR5-deficient MSNs MESH:D007153
3194 90357-90362 Disease denotes death MESH:D003643
3195 90443-90468 Disease denotes CCR5-deficient mixed glia MESH:D060085
3196 90772-90791 Disease denotes CCR5-deficient glia MESH:D007153
3197 91054-91069 Disease denotes CCR5 deficiency MESH:D007153
3198 91400-91410 Disease denotes neurotoxic MESH:D020258
3199 91601-91609 Disease denotes toxicity MESH:D064420
3200 91797-91814 Disease denotes opiate neurotoxic MESH:D020258
3201 91838-91853 Disease denotes CCR5 deficiency MESH:D007153
3223 87593-87597 Gene denotes BDNF Gene:627
3224 87599-87604 Gene denotes mBDNF Gene:12064
3225 87644-87648 Gene denotes TrkB Gene:4915
3226 87697-87701 Gene denotes BDNF Gene:627
3227 87707-87711 Gene denotes BDNF Gene:627
3228 87719-87725 Gene denotes p75NTR Gene:4804
3229 87840-87844 Gene denotes BDNF Gene:627
3230 87936-87940 Gene denotes BDNF Gene:627
3231 88033-88038 Gene denotes gp120 Gene:3700
3232 88074-88079 Gene denotes mBDNF Gene:12064
3233 88134-88138 Gene denotes CCR5 Gene:1234
3234 88179-88182 Gene denotes Tat Gene:6898
3235 88308-88311 Gene denotes Tat Gene:6898
3236 88379-88384 Gene denotes mBDNF Gene:12064
3237 88427-88431 Gene denotes CCR5 Gene:1234
3238 88069-88073 Gene denotes BDNF Gene:627
3239 88027-88032 Species denotes HIV-1 Tax:11676
3240 88316-88324 Chemical denotes morphine MESH:D009020
3241 87748-87753 Disease denotes death MESH:D003643
3242 87863-87875 Disease denotes HIV-infected MESH:D015658
3243 88236-88251 Disease denotes CCR5-deficiency MESH:D007153
3256 92345-92348 Gene denotes Tat Gene:6898
3257 92542-92546 Gene denotes CCR5 Gene:1234
3258 92572-92575 Gene denotes MOR Gene:4988
3259 92611-92615 Gene denotes BDNF Gene:627
3260 92712-92715 Gene denotes MOR Gene:4988
3261 92720-92724 Gene denotes CCR5 Gene:1234
3262 92248-92253 Gene denotes mBDNF Gene:12064
3263 92589-92592 Species denotes HIV Tax:12721
3264 92761-92764 Species denotes HIV Tax:12721
3265 92351-92359 Chemical denotes morphine MESH:D009020
3266 92315-92336 Disease denotes glial CCR5 deficiency MESH:D005910
3267 92422-92447 Disease denotes neurodegenerative disease MESH:D019636
3269 92841-92844 Species denotes HIV Tax:12721
3273 92918-92921 Species denotes HIV Tax:12721
3274 92978-92981 Species denotes HIV Tax:12721
3275 93231-93234 Species denotes HIV Tax:12721
3291 93374-93377 Gene denotes MOR Gene:4988
3292 93379-93382 Gene denotes KOR Gene:4986
3293 93388-93391 Gene denotes DOR Gene:58476
3294 93439-93458 Gene denotes proopiomelanocortin Gene:5443
3295 93460-93464 Gene denotes POMC Gene:5443
3296 93467-93479 Gene denotes prodynorphin Gene:5173
3297 93481-93485 Gene denotes PDYN Gene:5173
3298 93492-93505 Gene denotes proenkephalin Gene:5179
3299 93507-93511 Gene denotes PENK Gene:5179
3300 93640-93650 Gene denotes nociceptin Gene:5368
3301 93651-93662 Gene denotes orphanin FQ Gene:5368
3303 93734-93738 Disease denotes pain MESH:D010146
3304 93808-93827 Disease denotes neurologic diseases MESH:D020271
3305 93894-93898 Disease denotes pain MESH:D010146
3325 94080-94085 Gene denotes OPRK1 Gene:18387
3326 94413-94418 Gene denotes OPRK1 Gene:4986
3327 94649-94660 Gene denotes β-endorphin Gene:5443
3328 94874-94885 Gene denotes β-endorphin Gene:5443
3329 94902-94905 Gene denotes MOR Gene:4988
3330 94925-94928 Gene denotes KOR Gene:4986
3331 95006-95017 Gene denotes β-endorphin Gene:5443
3332 95234-95248 Gene denotes interleukin-1β Gene:3553
3333 95250-95255 Gene denotes IL-1β Gene:3552
3334 95326-95339 Gene denotes proenkephalin Gene:5179
3338 94156-94166 Species denotes transgenic Tax:10090
3341 94344-94357 Disease denotes HIV infection MESH:D015658
3342 95131-95143 Disease denotes inflammation MESH:D007249
3343 95159-95177 Disease denotes multiple sclerosis MESH:D009103
3352 95638-95642 Gene denotes PENK Gene:5179
3353 95804-95834 Gene denotes interferon regulatory factor 1 Gene:3659
3354 95836-95840 Gene denotes IRF1 Gene:3659
3355 96089-96093 Gene denotes PENK Gene:5179
3356 95719-95727 Species denotes patients Tax:9606
3357 95951-95956 Species denotes human Tax:9606
3358 95706-95709 Species denotes HIV Tax:12721
3359 95768-95771 Species denotes HIV Tax:12721
3372 96338-96342 Gene denotes PDYN Gene:18610
3373 96417-96420 Gene denotes Tat Gene:234724
3374 96438-96442 Gene denotes POMC Gene:18976
3375 96477-96480 Gene denotes Tat Gene:234724
3376 96511-96515 Gene denotes PENK Gene:18619
3377 96588-96591 Gene denotes Tat Gene:234724
3378 96270-96273 Gene denotes tat Gene:6898
3379 96141-96144 Gene denotes Tat Gene:6898
3380 96432-96436 Species denotes mice Tax:10090
3381 96804-96809 Species denotes HIV-1 Tax:11676
3382 96137-96140 Species denotes HIV Tax:12721
3383 96631-96634 Species denotes HIV Tax:12721
3397 97663-97693 Gene denotes corticotropin releasing factor Gene:1392
3398 97538-97546 Chemical denotes dopamine MESH:D004298
3399 97888-97896 Chemical denotes cortisol MESH:D006854
3400 98327-98336 Chemical denotes methadone MESH:D008691
3401 97457-97487 Disease denotes hypothalamic-pituitary-adrenal MESH:D007029
3402 97489-97492 Disease denotes HPA MESH:D010661
3403 97653-97656 Disease denotes HPA MESH:D010661
3404 97996-97999 Disease denotes HPA MESH:D010661
3405 98169-98172 Disease denotes HPA MESH:D010661
3406 98397-98400 Disease denotes HPA MESH:D010661
3407 98446-98459 Disease denotes HIV infection MESH:D015658
3408 98485-98488 Disease denotes HPA MESH:D010661
3409 98506-98514 Disease denotes toxicity MESH:D064420
3431 99815-99818 Species denotes HIV Tax:12721
3432 99874-99878 Gene denotes Nath Gene:80155
3433 98896-98902 Chemical denotes heroin MESH:D003932
3434 99087-99095 Chemical denotes morphine MESH:D009020
3435 99122-99130 Chemical denotes dopamine MESH:D004298
3436 99132-99141 Chemical denotes serotonin MESH:D012701
3437 99143-99162 Chemical denotes γ-aminobutyric acid MESH:D005680
3438 99164-99168 Chemical denotes GABA MESH:D005680
3439 99171-99184 Chemical denotes acetylcholine MESH:D000109
3440 99186-99195 Chemical denotes aspartate MESH:D001224
3441 99201-99210 Chemical denotes glutamate MESH:D018698
3442 99230-99238 Chemical denotes morphine MESH:D009020
3443 99437-99445 Chemical denotes dopamine MESH:D004298
3444 99450-99464 Chemical denotes norepinephrine MESH:D009638
3445 99552-99558 Chemical denotes Heroin MESH:D003932
3446 99670-99678 Chemical denotes dopamine MESH:D004298
3447 99846-99854 Chemical denotes dopamine MESH:D004298
3448 99948-99956 Chemical denotes dopamine MESH:D004298
3449 99971-99979 Chemical denotes dopamine MESH:D004298
3450 100085-100093 Chemical denotes dopamine MESH:D004298
3451 100118-100141 Disease denotes opioid abuse tendencies MESH:D009293
3464 100391-100394 Gene denotes MOR Gene:4988
3465 100438-100441 Gene denotes MOR Gene:4988
3466 100497-100499 Gene denotes Gα Gene:8802
3467 101127-101130 Gene denotes MOR Gene:4988
3468 100559-100562 Gene denotes RGS Gene:5308
3469 101554-101557 Species denotes HIV Tax:12721
3470 100339-100347 Chemical denotes morphine MESH:D009020
3471 100349-100358 Chemical denotes methadone MESH:D008691
3472 100364-100377 Chemical denotes buprenorphine MESH:D002047
3473 101210-101218 Chemical denotes morphine MESH:D009020
3474 101220-101229 Chemical denotes methadone MESH:D008691
3475 101233-101246 Chemical denotes buprenorphine MESH:D002047
3507 102321-102324 Gene denotes KOR Gene:4986
3508 102544-102547 Gene denotes MOR Gene:4988
3509 102604-102607 Gene denotes MOR Gene:4988
3510 102925-102928 Gene denotes MOR Gene:4988
3511 102933-102936 Gene denotes KOR Gene:4986
3512 103163-103166 Gene denotes Tat Gene:6898
3513 102236-102239 Gene denotes MOR Gene:4988
3514 102275-102278 Gene denotes MOR Gene:4988
3515 103327-103331 Gene denotes Hage Gene:55510
3516 103294-103298 Gene denotes Hage Gene:55510
3517 103224-103229 Species denotes HIV-1 Tax:11676
3518 101744-101747 Species denotes HIV Tax:12721
3519 102223-102232 Chemical denotes methadone MESH:D008691
3520 102258-102271 Chemical denotes buprenorphine MESH:D002047
3521 102366-102375 Chemical denotes methadone MESH:D008691
3522 102377-102390 Chemical denotes buprenorphine MESH:D002047
3523 103065-103073 Chemical denotes morphine MESH:D009020
3524 103075-103084 Chemical denotes methadone MESH:D008691
3525 103090-103103 Chemical denotes buprenorphine MESH:D002047
3526 103128-103131 Chemical denotes ROS
3527 103137-103141 Chemical denotes Ca2+ MESH:D000069285
3528 103203-103211 Chemical denotes Morphine MESH:D009020
3529 103376-103385 Chemical denotes methadone MESH:D008691
3530 103387-103396 Chemical denotes oxycodone MESH:D010098
3531 103398-103411 Chemical denotes buprenorphine MESH:D002047
3532 101834-101843 Disease denotes mortality MESH:D003643
3533 101882-101897 Disease denotes opioid overdose MESH:D062787
3534 102454-102458 Disease denotes ARVs
3535 102475-102501 Disease denotes opioid withdrawal symptoms MESH:D013375
3536 102722-102732 Disease denotes neurotoxic MESH:D020258
3544 103633-103636 Gene denotes MOR Gene:4988
3545 103924-103927 Gene denotes MOR Gene:4988
3546 103931-103933 Gene denotes Gα Gene:8802
3547 104001-104004 Gene denotes MOR Gene:4988
3548 104116-104119 Gene denotes MOR Gene:4988
3549 104279-104287 Disease denotes Williams MESH:D018980
3558 104573-104576 Gene denotes MOR Gene:4988
3559 104919-104922 Gene denotes MOR Gene:4988
3560 105045-105057 Gene denotes β-arrestin 2 Gene:409
3561 104659-104664 Species denotes HIV-1 Tax:11676
3562 104535-104538 Species denotes HIV Tax:12721
3563 104594-104607 Chemical denotes endomorphin-1 MESH:C105293
3564 104626-104634 Chemical denotes morphine MESH:D009020
3565 104680-104688 Disease denotes infected MESH:D007239
3595 105893-105926 Gene denotes cytochrome P450 (CYP) 3A4 and 2C8 Gene:1576
3596 106014-106051 Gene denotes UDP-glucuronosyltransferase (UGT) 1A1 Gene:54658
3597 106266-106273 Gene denotes CYP 3A4 Gene:1576
3598 106278-106285 Gene denotes UGT 1A1 Gene:54658
3599 106707-106714 Gene denotes CYP 3A4 Gene:1576
3600 107012-107019 Gene denotes CYP 3A4 Gene:1576
3601 105850-105863 Chemical denotes buprenorphine MESH:D002047
3602 105933-105946 Chemical denotes buprenorphine MESH:D002047
3603 105974-105990 Chemical denotes norbuprenorphine MESH:C043585
3604 106235-106245 Chemical denotes atazanavir MESH:D000069446
3605 106246-106255 Chemical denotes ritonavir MESH:D019438
3606 106340-106353 Chemical denotes buprenorphine MESH:D002047
3607 106358-106374 Chemical denotes norbuprenorphine MESH:C043585
3608 106520-106533 Chemical denotes buprenorphine MESH:D002047
3609 106579-106589 Chemical denotes atazanavir MESH:D000069446
3610 106626-106635 Chemical denotes Methadone MESH:D008691
3611 106799-106808 Chemical denotes methadone MESH:D008691
3612 106980-106989 Chemical denotes efavirenz MESH:C098320
3613 106994-107004 Chemical denotes nevirapine MESH:D019829
3614 107071-107080 Chemical denotes methadone MESH:D008691
3615 107170-107179 Chemical denotes methadone MESH:D008691
3616 107214-107223 Chemical denotes efavirenz MESH:C098320
3617 107227-107237 Chemical denotes nevirapine MESH:D019829
3618 107325-107334 Chemical denotes Oxycodone MESH:D010098
3619 107362-107381 Chemical denotes lopinavir/ritonavir MESH:C558899
3620 107394-107403 Chemical denotes oxycodone MESH:D010098
3621 105780-105784 Disease denotes ARVs
3622 106087-106091 Disease denotes ARVs
3623 107104-107130 Disease denotes opioid withdrawal symptoms MESH:D013375
3635 107902-107906 Gene denotes P-gp Gene:5243
3636 107773-107776 Gene denotes CSF Gene:3918
3637 107909-107912 Gene denotes CSF Gene:3918
3638 108460-108463 Gene denotes CSF Gene:3918
3639 108337-108340 Gene denotes CSF Gene:3918
3640 108211-108214 Gene denotes CSF Gene:3918
3641 108113-108116 Gene denotes CSF Gene:3918
3642 107759-107762 Gene denotes CSF Gene:3918
3643 108161-108171 Chemical denotes amprenavir MESH:C095108
3644 108191-108207 Chemical denotes [14C]-amprenavir
3645 108630-108634 Disease denotes ARVs
3656 109251-109255 Gene denotes P-gp Gene:5243
3657 109304-109308 Gene denotes P-gp Gene:5243
3658 108866-108874 Chemical denotes morphine MESH:D009020
3659 108904-108916 Chemical denotes dolutegravir MESH:C562325
3660 108918-108928 Chemical denotes lamivudine MESH:D019259
3661 108933-108941 Chemical denotes abacavir MESH:C106538
3662 108965-108973 Chemical denotes morphine MESH:D009020
3663 109150-109162 Chemical denotes dolutegravir MESH:C562325
3664 109167-109175 Chemical denotes abacavir MESH:C106538
3665 109280-109288 Chemical denotes Morphine MESH:D009020
3671 109385-109388 Species denotes HIV Tax:12721
3672 110254-110263 Chemical denotes darunavir MESH:D000069454
3673 110268-110279 Chemical denotes raltegravir MESH:D000068898
3674 109523-109531 Disease denotes infected MESH:D007239
3675 109644-109653 Disease denotes infection MESH:D007239
3684 110529-110534 Species denotes human Tax:9606
3685 110476-110488 Chemical denotes dolutegravir MESH:C562325
3686 110490-110499 Chemical denotes tenofovir MESH:D000068698
3687 110504-110517 Chemical denotes emtricitabine MESH:D000068679
3701 111558-111561 Gene denotes CD4 Gene:920
3702 111245-111253 Chemical denotes morphine MESH:D009020
3703 111309-111317 Chemical denotes morphine MESH:D009020
3704 111607-111615 Chemical denotes morphine MESH:D009020
3705 111731-111739 Chemical denotes morphine MESH:D009020
3706 111792-111800 Chemical denotes morphine MESH:D009020
3707 111884-111892 Chemical denotes morphine MESH:D009020
3708 111231-111243 Disease denotes SIV-infected MESH:D012857
3709 111389-111402 Disease denotes SIV infection MESH:D012857

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 98745-98772 http://purl.obolibrary.org/obo/GO_0042133 denotes neurotransmitter metabolism
T2 98762-98772 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T3 98777-98792 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T4 99670-99691 http://purl.obolibrary.org/obo/GO_0042416 denotes dopamine biosynthesis
T5 99679-99691 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T6 99855-99872 http://purl.obolibrary.org/obo/GO_0007268 denotes neurotransmission
T7 99971-99989 http://purl.obolibrary.org/obo/GO_0015872 denotes dopamine transport
T8 99980-99989 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T9 100159-100168 http://purl.obolibrary.org/obo/GO_0007610 denotes behaviors
T10 100317-100329 http://purl.obolibrary.org/obo/GO_0009405 denotes Pathogenesis
T11 100548-100557 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T12 102030-102036 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T13 102030-102036 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T14 102041-102050 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T15 103839-103848 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T16 104186-104204 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T17 104186-104195 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18 104384-104393 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T19 104827-104842 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T20 105893-105903 http://purl.obolibrary.org/obo/GO_0045158 denotes cytochrome
T21 105893-105903 http://purl.obolibrary.org/obo/GO_0045157 denotes cytochrome
T22 105893-105903 http://purl.obolibrary.org/obo/GO_0045156 denotes cytochrome
T23 105893-105903 http://purl.obolibrary.org/obo/GO_0008121 denotes cytochrome
T24 106462-106471 http://purl.obolibrary.org/obo/GO_0050890 denotes cognition
T25 107335-107345 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T26 107863-107869 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T27 107863-107869 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T28 109206-109212 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T29 109206-109212 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T30 109225-109231 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T31 109225-109231 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T32 109232-109241 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T33 109843-109856 http://purl.obolibrary.org/obo/GO_0003968 denotes transcriptase
T34 109843-109856 http://purl.obolibrary.org/obo/GO_0003899 denotes transcriptase
T35 109903-109916 http://purl.obolibrary.org/obo/GO_0003968 denotes transcriptase
T36 109903-109916 http://purl.obolibrary.org/obo/GO_0003899 denotes transcriptase
T37 109956-109984 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T38 109967-109984 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T39 109967-109984 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T40 110077-110102 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T41 110085-110102 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T42 110085-110102 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T96803 1065-1077 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T85650 1675-1684 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T12576 1851-1857 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T35890 1851-1857 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T14073 6012-6017 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T32162 6149-6158 http://purl.obolibrary.org/obo/GO_0050890 denotes cognition
T91677 6748-6763 http://purl.obolibrary.org/obo/GO_0006306 denotes DNA methylation
T65053 6752-6763 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T70233 7309-7325 http://purl.obolibrary.org/obo/GO_0150103 denotes reactive gliosis
T51458 8264-8273 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T8927 9196-9202 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T19813 9856-9868 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T25593 10260-10269 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T77592 10504-10532 http://purl.obolibrary.org/obo/GO_1990708 denotes conditioned place preference
T42576 10601-10613 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T73341 10629-10657 http://purl.obolibrary.org/obo/GO_1990708 denotes conditioned place preference
T36640 12013-12022 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T71218 12777-12789 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T29450 13027-13035 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior
T85138 13815-13827 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T40073 14159-14164 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T73616 14226-14235 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T73908 14418-14423 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T70017 16523-16535 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18180 16686-16692 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T79044 16705-16711 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T60696 18527-18543 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T35984 18638-18654 http://purl.obolibrary.org/obo/GO_0002524 denotes hypersensitivity
T69969 18740-18755 http://purl.obolibrary.org/obo/GO_0007611 denotes Learning-memory
T74458 18740-18748 http://purl.obolibrary.org/obo/GO_0007612 denotes Learning
T70873 18749-18755 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T14119 18807-18815 http://purl.obolibrary.org/obo/GO_0007612 denotes learning
T38670 18819-18827 http://purl.obolibrary.org/obo/GO_0007612 denotes Learning
T338 18927-18933 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T64140 18946-18952 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T84433 19358-19364 http://purl.obolibrary.org/obo/GO_0007613 denotes Memory
T61490 19436-19442 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T75389 20741-20746 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T57833 22816-22831 http://purl.obolibrary.org/obo/GO_0043524 denotes neuron survival
T93715 23020-23035 http://purl.obolibrary.org/obo/GO_0043524 denotes neuron survival
T1026 23145-23166 http://purl.obolibrary.org/obo/GO_0007268 denotes Synaptic transmission
T99406 26390-26413 http://purl.obolibrary.org/obo/GO_0050900 denotes Immune cell trafficking
T43 26538-26543 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T44 26864-26881 http://purl.obolibrary.org/obo/GO_0007623 denotes Circadian rhythms
T45 27299-27327 http://purl.obolibrary.org/obo/GO_1990708 denotes conditioned place preference
T46 28774-28787 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T47 28840-28853 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T48 31151-31160 http://purl.obolibrary.org/obo/GO_0016236 denotes Autophagy
T49 31151-31160 http://purl.obolibrary.org/obo/GO_0006914 denotes Autophagy
T50 31546-31556 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T51 31938-31955 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T52 32644-32668 http://purl.obolibrary.org/obo/GO_0030182 denotes neuronal differentiation
T53 33352-33365 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T54 34064-34076 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T55 34142-34151 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T56 35665-35674 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T57 36238-36249 http://purl.obolibrary.org/obo/GO_0042592 denotes Homeostasis
T58 36780-36797 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T59 36822-36839 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T60 37050-37054 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T61 37088-37094 http://purl.obolibrary.org/obo/GO_0016538 denotes Cyclin
T62 37193-37210 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T63 37215-37232 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T64 38127-38144 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T65 38344-38361 http://purl.obolibrary.org/obo/GO_0043524 denotes Neuronal survival
T66 38749-38762 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T67 38753-38762 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T68 38801-38814 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T69 38805-38814 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T70 42922-42931 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T71 42922-42931 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T72 43247-43261 http://purl.obolibrary.org/obo/GO_0070997 denotes neuronal death
T73 44270-44282 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T74 44816-44829 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T75 44912-44924 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T76 45052-45070 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascades
T77 45052-45061 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T78 46411-46423 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T79 46496-46511 http://purl.obolibrary.org/obo/GO_0071605 denotes CCL2 production
T80 46609-46621 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T81 48727-48746 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T82 48750-48770 http://purl.obolibrary.org/obo/GO_0043278 denotes response to morphine
T83 48895-48906 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T84 49354-49366 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T85 49596-49611 http://purl.obolibrary.org/obo/GO_0050801 denotes ion homeostasis
T86 49600-49611 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T87 49825-49834 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T88 50391-50406 http://purl.obolibrary.org/obo/GO_0050801 denotes ion homeostasis
T89 50395-50406 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T90 52102-52113 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T91 52203-52223 http://purl.obolibrary.org/obo/GO_0051209 denotes calcium mobilization
T92 53258-53292 http://purl.obolibrary.org/obo/GO_0004883 denotes glucocorticoid receptor activation
T93 53258-53292 http://purl.obolibrary.org/obo/GO_0004879 denotes glucocorticoid receptor activation
T94 53685-53696 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T95 53829-53838 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T96 54913-54919 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T97 54913-54919 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T98 54938-54952 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T99 55359-55373 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T100 55364-55373 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T101 56646-56652 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T102 56646-56652 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T103 56653-56662 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T104 56990-57004 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T105 56995-57004 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T106 57999-58027 http://purl.obolibrary.org/obo/GO_0004601 denotes horseradish peroxidase (HRP)
T107 60687-60710 http://purl.obolibrary.org/obo/GO_0050900 denotes immune cell trafficking
T108 60844-60855 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T109 60874-60883 http://purl.obolibrary.org/obo/GO_0009056 denotes Breakdown
T110 61230-61244 http://purl.obolibrary.org/obo/GO_0015893 denotes drug transport
T111 61235-61244 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T112 61803-61809 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T113 61803-61809 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T114 61832-61846 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T115 61861-61869 http://purl.obolibrary.org/obo/GO_0140352 denotes effluxes
T116 61861-61869 http://purl.obolibrary.org/obo/GO_0140115 denotes effluxes
T117 62048-62057 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T118 62193-62199 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T119 62193-62199 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T120 62200-62211 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T121 62980-62986 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T122 64628-64643 http://purl.obolibrary.org/obo/GO_0004972 denotes (NMDA) receptor
T123 65032-65041 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T124 65127-65133 http://purl.obolibrary.org/obo/GO_0004683 denotes CaMKII
T125 65822-65833 http://purl.obolibrary.org/obo/GO_0042552 denotes myelination
T126 66195-66201 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T127 66933-66940 http://purl.obolibrary.org/obo/GO_0150103 denotes gliosis
T128 67428-67440 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T129 68251-68260 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T130 68820-68832 http://purl.obolibrary.org/obo/GO_0022008 denotes neurogenesis
T131 69427-69439 http://purl.obolibrary.org/obo/GO_0022008 denotes neurogenesis
T132 69486-69507 http://purl.obolibrary.org/obo/GO_0000075 denotes cell cycle checkpoint
T133 69486-69496 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T134 69527-69531 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T135 69606-69615 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T136 69636-69642 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T137 69926-69947 http://purl.obolibrary.org/obo/GO_0048699 denotes generation of neurons
T138 70002-70006 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T139 70007-70011 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T140 70064-70070 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T141 70108-70116 http://purl.obolibrary.org/obo/GO_0051318 denotes G1 phase
T142 70124-70134 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T143 71141-71162 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T144 71152-71162 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T145 72493-72497 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T146 74323-74329 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T147 74909-74928 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T148 75954-75966 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T149 76051-76058 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T150 78529-78538 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T151 78816-78824 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T152 78903-78912 http://purl.obolibrary.org/obo/GO_0007610 denotes behaviors
T153 79161-79176 http://purl.obolibrary.org/obo/GO_0017144 denotes drug metabolism
T154 79166-79176 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T155 79373-79383 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T156 79403-79421 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine secretion
T157 79412-79421 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T158 79775-79783 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T159 80655-80660 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T160 80880-80885 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T161 81084-81093 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T162 81568-81583 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T163 81866-81871 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T164 82075-82080 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T165 82191-82200 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T166 82283-82288 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T167 82470-82479 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T168 84206-84216 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T169 86042-86052 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T170 87476-87485 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T171 87743-87753 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T172 89276-89293 http://purl.obolibrary.org/obo/GO_0043524 denotes neuronal survival
T173 90341-90362 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T174 90352-90362 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T175 91865-91874 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T176 91975-91992 http://purl.obolibrary.org/obo/GO_0043524 denotes neuronal survival
T177 92292-92304 http://purl.obolibrary.org/obo/GO_0043066 denotes pro-survival
T178 92576-92585 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T179 93264-93276 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T180 93739-93749 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T181 95131-95143 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T182 97710-97725 http://purl.obolibrary.org/obo/GO_0006694 denotes steroidogenesis
T183 98519-98538 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes Opioid and neuroHIV Comorbidity – Current and Future Perspectives
T2 67-75 Sentence denotes Abstract
T3 76-290 Sentence denotes With the current national opioid crisis, it is critical to examine the mechanisms underlying pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in the central nervous system (CNS).
T4 291-479 Sentence denotes Recent advances in experimental models, methodology, and our understanding of disease processes at the molecular and cellular levels reveal opioid-HIV interactions with increasing clarity.
T5 480-687 Sentence denotes However, despite the substantial new insight, the unique impact of opioids on the severity, progression, and prognosis of neuroHIV and HIV-associated neurocognitive disorders (HAND) are not fully understood.
T6 688-913 Sentence denotes In this review, we explore, in detail, what is currently known about mechanisms underlying opioid interactions with HIV, with emphasis on individual HIV-1-expressed gene products at the molecular, cellular and systems levels.
T7 914-1165 Sentence denotes Furthermore, we review preclinical and clinical studies with a focus on key considerations when addressing questions of whether opioid-HIV interactive pathogenesis results in unique structural or functional deficits not seen with either disease alone.
T8 1166-1368 Sentence denotes These considerations include, understanding the combined consequences of HIV-1 genetic variants, host variants, and μ-opioid receptor (MOR) and HIV chemokine co-receptor interactions on the comorbidity.
T9 1369-1528 Sentence denotes Lastly, we present topics that need to be considered in the future to better understand the unique contributions of opioids to the pathophysiology of neuroHIV.
T10 1529-1596 Sentence denotes Graphical Abstract Blood-brain barrier and the neurovascular unit.
T11 1597-1775 Sentence denotes With HIV and opiate co-exposure (represented below the dotted line), there is breakdown of tight junction proteins and increased leakage of paracellular compounds into the brain.
T12 1776-1928 Sentence denotes Despite this, opiate exposure selectively increases the expression of some efflux transporters, thereby restricting brain penetration of specific drugs.
T13 1930-1938 Sentence denotes Overview
T14 1940-1957 Sentence denotes The Opioid Crisis
T15 1958-2031 Sentence denotes Opioid abuse in the United States (U.S.) has reached catastrophic levels.
T16 2032-2187 Sentence denotes According to the latest World Drug Report, 53.4 million people worldwide used opioids in 2017, which is 56% higher than in the previous year (UNODC 2019a).
T17 2188-2346 Sentence denotes North America remains the region with the highest non-medical use of opioids with a staggering 4% of the population aged 15–64 using opioids (UNODC 2019a, c).
T18 2347-2551 Sentence denotes In 2017, the burden of opioid use in the U.S. had accounted for 42 million healthy years of life lost due to premature death and disability (Institute for Health Metrics and Evaluation 2017; UNODC 2019a).
T19 2552-2709 Sentence denotes During 2017, there were 70,237 overdose related deaths, out of which 47,600 (67.8%) were caused by opioids, which was a 12% increase from 2016 (Scholl et al.
T20 2710-2729 Sentence denotes 2018; UNODC 2019c).
T21 2730-2868 Sentence denotes The Centers of Disease Control and Prevention (CDC) reports that on average 130 Americans die from an opioid overdose each day (CDC 2017).
T22 2869-2931 Sentence denotes Due to the constant rise in deaths involving opioids, the U.S.
T23 2932-3018 Sentence denotes Government declared the opioid crisis/epidemic a public health emergency in 2017 (U.S.
T24 3019-3065 Sentence denotes Department of Health and Human Services 2017).
T25 3066-3271 Sentence denotes Injection drug use increases the likelihood of contracting human immunodeficiency virus (HIV) and drug abuse and HIV have long been described as interrelated epidemics (Swan 1997; Leshner 1998; Nath et al.
T26 3272-3284 Sentence denotes 1999, 2002).
T27 3285-3424 Sentence denotes Despite this understanding, opioid use disorder (OUD) and HIV remain a huge public health concern (Strathdee and Beyrer 2015; Peters et al.
T28 3425-3431 Sentence denotes 2016).
T29 3432-3609 Sentence denotes In fact, the opioid crisis is seen as a major roadblock in several aspects of public health, including thwarting the goal of eliminating HIV within the next decade (Fauci et al.
T30 3610-3639 Sentence denotes 2019; Lerner and Fauci 2019).
T31 3640-3737 Sentence denotes OUD is also likely to exacerbate many negative aspects of the COVID-19 pandemic (Alexander et al.
T32 3738-3794 Sentence denotes 2020; Becker and Fiellin 2020; NIDA 2020; Wakeman et al.
T33 3795-3801 Sentence denotes 2020).
T34 3802-4164 Sentence denotes Not only are individuals with OUD more vulnerable to SARS-CoV-2 and liable to spread the infection, social-distancing practices create isolation, despair, and economic hardships, heightening opioid abuse (with inherent respiratory depression depending on the amount of tolerance developed) and the probability of overdose (Becker and Fiellin 2020; Wakeman et al.
T35 4165-4171 Sentence denotes 2020).
T36 4172-4421 Sentence denotes By virtue of its greater safety profile and decreased likelihood for abuse (Bell and Strang 2020), the use of buprenorphine via telemedicine has become advantageous for managing OUD during the COVID-19 pandemic (Leppla and Gross 2020; Samuels et al.
T37 4422-4482 Sentence denotes 2020) but presents new challenges (Khatri and Perrone 2020).
T38 4483-4593 Sentence denotes The current opioid crisis did not happen quickly; in fact, it has been described as occurring in three phases.
T39 4594-4689 Sentence denotes The first phase began in the late 1990s with an increase in the number of prescription opioids.
T40 4690-4814 Sentence denotes This led to overdose deaths that were attributable to natural and semi-synthetic opioids, such as methadone (Kolodyny et al.
T41 4815-4831 Sentence denotes 2015; CDC 2017).
T42 4832-4935 Sentence denotes The second phase began in 2010 in which heroin took the lead as the principal cause of overdose deaths.
T43 4936-5105 Sentence denotes The most recent, third wave, began in 2013 in which highly potent synthetic opioids, such as fentanyl and its analogs became the main cause of mortality (Kolodyny et al.
T44 5106-5122 Sentence denotes 2015; CDC 2017).
T45 5123-5246 Sentence denotes The entry of fentanyl and its analogs into the clandestine market has changed the dynamics of the opioid market in the U.S.
T46 5247-5470 Sentence denotes The synthetic opioids, such as fentanyl, are several orders of magnitude more potent than morphine, easily smuggled, and frequently and inconsistently mixed with lower quality drugs increasing the probability of overdosing.
T47 5471-5547 Sentence denotes According to the National Forensic Laboratory Information System of the U.S.
T48 5548-5718 Sentence denotes Drug Enforcement Administration (DEA), fentanyl accounted for one-third of the illicit opioids seized in 2017 (UNODC 2019c) and has become a global problem (UNODC 2019b).
T49 5720-5755 Sentence denotes The Pathophysiology of Opioid Abuse
T50 5756-5851 Sentence denotes The effects of opioid abuse on the central nervous system (CNS) have been extensively examined.
T51 5852-6109 Sentence denotes Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004).
T52 6110-6205 Sentence denotes While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al.
T53 6206-6302 Sentence denotes 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al.
T54 6303-6322 Sentence denotes 2000; Dublin et al.
T55 6323-6343 Sentence denotes 2015; Roberts et al.
T56 6344-6364 Sentence denotes 2018; Wollman et al.
T57 6365-6386 Sentence denotes 2019; Serafini et al.
T58 6387-6598 Sentence denotes 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al.
T59 6599-6618 Sentence denotes 2006; Browne et al.
T60 6619-6625 Sentence denotes 2020).
T61 6626-6887 Sentence denotes The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al.
T62 6888-6907 Sentence denotes 2010; Dublin et al.
T63 6908-6976 Sentence denotes 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al.
T64 6977-6983 Sentence denotes 2020).
T65 6984-7158 Sentence denotes Up to 90% of post-mortem tissues sampled from opiate abusers display brain edema (Buttner 2011), astrogliosis and microgliosis especially in the hippocampus (Oehmichen et al.
T66 7159-7232 Sentence denotes 1996), white matter, and subcortical regions at autopsy (Tomlinson et al.
T67 7233-7253 Sentence denotes 1999; Anthony et al.
T68 7254-7274 Sentence denotes 2005; Buttner et al.
T69 7275-7304 Sentence denotes 2006; Buttner and Weis 2006).
T70 7305-7493 Sentence denotes The reactive gliosis is accompanied by increases in proinflammatory cytokines and inflammatory mediators, including TNF-α, IL-1β, and nitric oxide synthase (NOS) (Dyuizen and Lamash 2009).
T71 7494-7764 Sentence denotes Opiates especially drive the enhanced activation of heme-oxygenase, NOS, and cyclic GMP-dependent-protein kinase (Liang and Clark 2004) and production of reactive nitrogen species (RNS) such as peroxynitrite (Salvemini 2009), and resultant nitrosative damage (Zou et al.
T72 7765-7771 Sentence denotes 2011).
T73 7772-7853 Sentence denotes Nitrosative damage is an important endpoint for opiate exposure (Pasternak et al.
T74 7854-8022 Sentence denotes 1995; Liang and Clark 2004; Salvemini 2009) and key site of convergence for the oxidative stress accompanying HIV protein exposure (Hauser and Knapp 2014; McLane et al.
T75 8023-8029 Sentence denotes 2018).
T76 8030-8360 Sentence denotes For delayed heroin overdose death after a survival period of 5 h or more, studies report neurovascular disorders, hypoxic ischemic leukoencephalopathy, and region-specific atrophy with neuronal losses that can include the hippocampal formation, the cerebellar Purkinje cell layer and olivary nucleus (Protass 1971; Ginsberg et al.
T77 8361-8383 Sentence denotes 1976; Gosztonyi et al.
T78 8384-8441 Sentence denotes 1993), as well as other areas (Buttner 2011; Cadet et al.
T79 8442-8448 Sentence denotes 2014).
T80 8449-8646 Sentence denotes Loss of neurons and synaptic connections is supported by postmortem reports of smaller mean relative volumes in various brain regions in individuals with OUD, including cortical areas (Danos et al.
T81 8647-8667 Sentence denotes 1998; Pezawas et al.
T82 8668-8707 Sentence denotes 1998), the basal ganglia (Muller et al.
T83 8708-8752 Sentence denotes 2015, 2019), prefrontal cortex (Cadet et al.
T84 8753-8791 Sentence denotes 2014), and hypothalamus (Muller et al.
T85 8792-8798 Sentence denotes 2018).
T86 8799-8856 Sentence denotes Interestingly, leukoencephalopathy, atrophy (Cadet et al.
T87 8857-9023 Sentence denotes 2014), and increased hyperphosphorylated tau-containing neurofibrillary tangles are reported with chronic opiate abuse compared to age-matched controls (Ramage et al.
T88 9024-9044 Sentence denotes 2005; Anthony et al.
T89 9045-9064 Sentence denotes 2010; Kovacs et al.
T90 9065-9071 Sentence denotes 2015).
T91 9072-9385 Sentence denotes Glycogen synthase kinase 3 α or β (GSK-3α/β; the pan antibody used in this study does not discern α from β isoforms) and/or cyclin-dependent kinase-5 (Cdk-5) are increased in the frontal and temporal cortices, the locus coeruleus, and the hippocampus, respectively, and correlate with microgliosis (Anthony et al.
T92 9386-9392 Sentence denotes 2010).
T93 9393-9528 Sentence denotes Further, more prolonged use increases the risk of accelerated age-related and even Alzheimer’s-like pathological changes (Ramage et al.
T94 9529-9549 Sentence denotes 2005; Anthony et al.
T95 9550-9569 Sentence denotes 2010; Kovacs et al.
T96 9570-9615 Sentence denotes 2015) and cognitive impairment (Gruber et al.
T97 9616-9622 Sentence denotes 2007).
T98 9623-9903 Sentence denotes Moreover, heroin use is associated with symmetric T2 and fluid-attenuated inversion recovery (FLAIR) hyperintense white matter lesions of the CNS using magnetic resonance imaging (MRI), which coincide with increased microgliosis and inflammation at the same sites (Upadhyay et al.
T99 9904-9921 Sentence denotes 2010; Bora et al.
T100 9922-9938 Sentence denotes 2012; Qiu et al.
T101 9939-9957 Sentence denotes 2013; Alaee et al.
T102 9958-9973 Sentence denotes 2014; Li et al.
T103 9974-9992 Sentence denotes 2016; Shrot et al.
T104 9993-9999 Sentence denotes 2017).
T105 10000-10203 Sentence denotes Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.
T106 10204-10344 Sentence denotes Preclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al.
T107 10345-10368 Sentence denotes 2006; Hutchinson et al.
T108 10369-10381 Sentence denotes 2008, 2009).
T109 10382-10547 Sentence denotes Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al.
T110 10548-10554 Sentence denotes 2006).
T111 10555-10716 Sentence denotes Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al.
T112 10717-10740 Sentence denotes 2006; Hutchinson et al.
T113 10741-10757 Sentence denotes 2009; Liu et al.
T114 10758-10912 Sentence denotes 2010). μ (MOR), δ (DOR), and κ (KOR) opioid receptors are expressed by subsets of astrocytes and microglia (Stiene-Martin and Hauser 1991; Eriksson et al.
T115 10913-10939 Sentence denotes 1992; Stiene-Martin et al.
T116 10940-10960 Sentence denotes 1993; Ruzicka et al.
T117 10961-10981 Sentence denotes 1995; Gurwell et al.
T118 10982-11001 Sentence denotes 1993; Hauser et al.
T119 11002-11030 Sentence denotes 1996; Turchan-Cholewo et al.
T120 11031-11050 Sentence denotes 2008; Maduna et al.
T121 11051-11214 Sentence denotes 2018) and are involved in opioid tolerance and dependence to varying degrees (Kieffer and Gaveriaux-Ruff 2002; Berger and Whistler 2010; Morgan and Christie 2011).
T122 11215-11327 Sentence denotes Despite some reports of morphine triggering immune activation via Toll-like receptor 4 (TLR4) (Terashvili et al.
T123 11328-11351 Sentence denotes 2008; Hutchinson et al.
T124 11352-11403 Sentence denotes 2010; Coller and Hutchinson 2012; Hutchinson et al.
T125 11404-11425 Sentence denotes 2012; Theberge et al.
T126 11426-11448 Sentence denotes 2013; Lacagnina et al.
T127 11449-11530 Sentence denotes 2017) by binding to a myeloid differentiation protein-2 intermediary (Wang et al.
T128 11531-11725 Sentence denotes 2012), this is contrary to the typical actions of opiates, which by themselves (and in the absence of a priming event such as HIV co-exposure) tend to suppress immune function (Eisenstein 2019).
T129 11726-11880 Sentence denotes A vast majority of the immune, antinociceptive, and other physiological effects of opioids are mediated by opioid receptors per se and not TLR4 (Hu et al.
T130 11881-11902 Sentence denotes 2011; Fukagawa et al.
T131 11903-11923 Sentence denotes 2013; Stevens et al.
T132 11924-11945 Sentence denotes 2013; Mattioli et al.
T133 11946-11969 Sentence denotes 2014; Eisenstein 2019).
T134 11970-12110 Sentence denotes Overall, the findings indicate that immune signaling plays a critical role in the pathophysiology of OUD and associated physical dependence.
T135 12111-12289 Sentence denotes How opioids effect neuroHIV, as well as how opioid abuse and dependence are altered by neuroHIV or whether opioid-HIV interactions result in a unique disease state are discussed.
T136 12291-12383 Sentence denotes HIV Neuropathology in the Context of Opioid Use Disorder – Clinical and Preclinical Evidence
T137 12385-12440 Sentence denotes Preclinical and Clinical Findings—a Complicated Picture
T138 12441-12555 Sentence denotes People infected with HIV (PWH) with OUD have an increased incidence of neuroHIV and CNS complications (Bell et al.
T139 12556-12573 Sentence denotes 1998; Nath et al.
T140 12574-12607 Sentence denotes 1999, 2000a, 2002; Anthony et al.
T141 12608-12626 Sentence denotes 2008; Meyer et al.
T142 12627-12645 Sentence denotes 2013; Smith et al.
T143 12646-12652 Sentence denotes 2014).
T144 12653-12729 Sentence denotes Injection drug use increases the probability of contracting HIV (Nath et al.
T145 12730-12797 Sentence denotes 1999) and opioid drugs intrinsically alter the pathogenesis of HIV.
T146 12798-12935 Sentence denotes PWH who develop intractable pain syndromes related to peripheral neuropathies often receive opioid drugs for treatment (Mirsattari et al.
T147 12936-12954 Sentence denotes 1999; Denis et al.
T148 12955-12961 Sentence denotes 2019).
T149 12962-13137 Sentence denotes PWH who misuse opioids are more likely to undertake risky sexual behavior and are less likely to adhere to combined antiretroviral (ARV) therapy (cART) regimens (Lemons et al.
T150 13138-13144 Sentence denotes 2019).
T151 13145-13308 Sentence denotes Opioid receptors are widely expressed on immune cells and opioids can modulate immune function (Donahoe and Falek 1988; Plotnikoff 1988; Rouveix 1992; Adler et al.
T152 13309-13347 Sentence denotes 1993; Carr and Serou 1995; Carr et al.
T153 13348-13366 Sentence denotes 1996; Sheng et al.
T154 13367-13388 Sentence denotes 1997; Banerjee et al.
T155 13389-13409 Sentence denotes 2011; Purohit et al.
T156 13410-13493 Sentence denotes 2012), which typically (but not always) result in immune suppression (Wybran et al.
T157 13494-13516 Sentence denotes 1979; McDonough et al.
T158 13517-13567 Sentence denotes 1980, 1981; Donahoe and Falek 1988; Donahoe et al.
T159 13568-13586 Sentence denotes 1991; Falek et al.
T160 13587-13606 Sentence denotes 1991; Novick et al.
T161 13607-13624 Sentence denotes 1991; Chao et al.
T162 13625-13647 Sentence denotes 1996a; Peterson et al.
T163 13648-13692 Sentence denotes 1998; Rogers and Peterson 2003; Stein et al.
T164 13693-13709 Sentence denotes 2003; Roy et al.
T165 13710-13730 Sentence denotes 2006; Rittner et al.
T166 13731-13737 Sentence denotes 2008).
T167 13738-13994 Sentence denotes The “opiate cofactor hypothesis” proposes opioids contribute directly to the pathogenesis of acquired immune deficiency syndrome (AIDS) (Donahoe and Vlahov 1998), in part, because MOR activation can increase HIV replication in immune cells (Peterson et al.
T168 13995-14028 Sentence denotes 1990, 1992, 1993, 1999; Ho et al.
T169 14029-14035 Sentence denotes 2003).
T170 14036-14110 Sentence denotes Furthermore, MOR and HIV co-receptors, including both CCR5 (El-Hage et al.
T171 14111-14128 Sentence denotes 2013; Yuan et al.
T172 14129-14148 Sentence denotes 2013; Arnatt et al.
T173 14149-14180 Sentence denotes 2016) and CXCR4 (Pitcher et al.
T174 14181-14296 Sentence denotes 2014) can interact via convergent downstream signaling and perhaps via direct molecular interactions (Rogers et al.
T175 14297-14342 Sentence denotes 2000; Rogers and Peterson 2003; Steele et al.
T176 14343-14360 Sentence denotes 2003; Chen et al.
T177 14361-14378 Sentence denotes 2004; Song et al.
T178 14379-14398 Sentence denotes 2011; Arnatt et al.
T179 14399-14405 Sentence denotes 2016).
T180 14406-14486 Sentence denotes MOR-CCR5 or CXCR4 interactions are highly contextual and can promote (Guo et al.
T181 14487-14506 Sentence denotes 2002; Steele et al.
T182 14507-14539 Sentence denotes 2003) or inhibit (Strazza et al.
T183 14540-14637 Sentence denotes 2014) HIV expression, depending on the nature and duration of exposure (see Fig. 9; Berman et al.
T184 14638-14678 Sentence denotes 2006) and cell type involved (Kim et al.
T185 14679-14685 Sentence denotes 2018).
T186 14686-14790 Sentence denotes Depending on the outcome measure, Tat expression reduces morphine’s efficacy and potency (Fitting et al.
T187 14791-14814 Sentence denotes 2012, 2016; Hahn et al.
T188 14815-14821 Sentence denotes 2016).
T189 14822-14996 Sentence denotes Antagonizing CCR5 with maraviroc reinstates morphine potency in an antinociceptive assay and restores physical dependence in Tat exposed, morphine-tolerant mice (Gonek et al.
T190 14997-15003 Sentence denotes 2018).
T191 15004-15109 Sentence denotes Epidemiological studies suggest OUD can increase AIDS progression (Donahoe and Vlahov 1998; Dronda et al.
T192 15110-15132 Sentence denotes 2004; Meijerink et al.
T193 15133-15145 Sentence denotes 2014, 2015).
T194 15146-15240 Sentence denotes In the pre-cART era, opiate abuse was found to exacerbate HIV encephalitis (HIVE) (Bell et al.
T195 15241-15253 Sentence denotes 1998, 2002).
T196 15254-15425 Sentence denotes In Indonesian injection heroin abusers who lacked access to cART, CD4 counts (a measure of HIV progression) were reduced compared to PWH not using heroin (Meijerink et al.
T197 15426-15432 Sentence denotes 2014).
T198 15433-15786 Sentence denotes However, with the introduction of cART, the clinical picture has significantly changed with a 50% decline in the rate of death from AIDS, reduced incidence of opportunistic infections and HIVE, and a 40–50% decrease in the incidence of HIV-associated dementia (HAD), the most severe form of HIV-associated neurocognitive disorders (HAND) (Maschke et al.
T199 15787-15808 Sentence denotes 2000; McArthur et al.
T200 15809-15828 Sentence denotes 2010; Saylor et al.
T201 15829-15835 Sentence denotes 2016).
T202 15836-15996 Sentence denotes Nevertheless, chronic opiate exposure (which almost always is confounded by the use of other illicit and legal drugs) in PWH can worsen neuroHIV (Anthony et al.
T203 15997-16014 Sentence denotes 2005; Bell et al.
T204 16015-16035 Sentence denotes 2006; Anthony et al.
T205 16036-16092 Sentence denotes 2008) and cognitive impairment (Rodriguez Salgado et al.
T206 16093-16142 Sentence denotes 2006; Martin-Thormeyer and Paul 2009; Byrd et al.
T207 16143-16161 Sentence denotes 2011; Smith et al.
T208 16162-16181 Sentence denotes 2014; Martin et al.
T209 16182-16200 Sentence denotes 2018; Rubin et al.
T210 16201-16301 Sentence denotes 2018) despite cART, even though some studies fail to show that opioids worsen neuroHIV (Royal et al.
T211 16302-16324 Sentence denotes 1991; Applebaum et al.
T212 16325-16353 Sentence denotes 2010) or HAND (Martin et al.
T213 16354-16360 Sentence denotes 2019).
T214 16361-16444 Sentence denotes Opiate exposure in cART-treated PWH worsens CD4 counts and viral loads (Ryan et al.
T215 16445-16511 Sentence denotes 2004), neuropathology (including increased tauopathy; Smith et al.
T216 16512-16551 Sentence denotes 2014), CNS inflammation (Anthony et al.
T217 16552-16576 Sentence denotes 2005, 2008; Smith et al.
T218 16577-16620 Sentence denotes 2014), and neurocognition (Applebaum et al.
T219 16621-16638 Sentence denotes 2009; Byrd et al.
T220 16639-16657 Sentence denotes 2011; Meyer et al.
T221 16658-16724 Sentence denotes 2013) including deficits in memory and working memory (Byrd et al.
T222 16725-16731 Sentence denotes 2011).
T223 16732-16887 Sentence denotes Table 1 gives an overview on reported interactive effects of HIV and opioids in some of the clinical and preclinical CNS studies referenced in this review.
T224 16888-16929 Sentence denotes Table 1 Clinical and preclinical findings
T225 16930-17002 Sentence denotes Major effects HIV pathogena ARV Opioids Outcome Model system Citation(s)
T226 17003-17028 Sentence denotes Clinical findings (human)
T227 17029-17080 Sentence denotes HIV progression and/or ARV adherence HIV cART • SUD
T228 17081-17136 Sentence denotes • Prescription opioids for pain • ↑ Viral load with SUD
T229 17137-17154 Sentence denotes • ↓ ARV adherence
T230 17155-17226 Sentence denotes • ↑ Frequency of prescription drugs with pain + SUD Human (Denis et al.
T231 17227-17232 Sentence denotes 2019)
T232 17233-17275 Sentence denotes HIV cART OUD • ↓ Lasting viral suppression
T233 17276-17330 Sentence denotes • ↓ Adherence to cART for 3 years Human (Lemons et al.
T234 17331-17336 Sentence denotes 2019)
T235 17337-17406 Sentence denotes HIV ARV naive Injection drug use ↓ CD4 counts Human (Meijerink et al.
T236 17407-17412 Sentence denotes 2014)
T237 17413-17436 Sentence denotes HIV encephalitis (HIVE)
T238 17437-17517 Sentence denotes HIV infection CNS HIV ZDV Former drug use (+ OST) • ↑ Multinucleated giant cells
T239 17518-17566 Sentence denotes • ↑ HIV p24 Human, postmortem brain (Bell et al.
T240 17567-17572 Sentence denotes 1998)
T241 17573-17604 Sentence denotes Microglial activation HIV • ARV
T242 17605-17706 Sentence denotes • ZDV OUD ↑ CD68 microglial activation only in non-OUD HIV+ PWH Human, postmortem brain (Smith et al.
T243 17707-17712 Sentence denotes 2014)
T244 17713-17722 Sentence denotes HIV • ARV
T245 17723-17819 Sentence denotes • ZDV, other monotherapies Injection drug use (+ OST) ↑ Microglial activation Human (Bell et al.
T246 17820-17825 Sentence denotes 2002)
T247 17826-17863 Sentence denotes HIV No info Drug use • ↑ MHC class II
T248 17864-17912 Sentence denotes • ↑ CD68 Human, postmortem brain (Anthony et al.
T249 17913-17918 Sentence denotes 2005)
T250 17919-18010 Sentence denotes HIV No info OUD (44% methadone, 36% other opiates) • ↓ CD68, HLA-D in HIV and HIVE with OUD
T251 18011-18074 Sentence denotes • No effect of IDU on CD68 Human, postmortem brain (Byrd et al.
T252 18075-18080 Sentence denotes 2012)
T253 18081-18207 Sentence denotes Plasma cytokines HIV cART OUD (codeine, fentanyl, morphine) ↑ sTNF-R2, not sCD14, TNF-α, sTNF-R1, in plasma Human (Ryan et al.
T254 18208-18213 Sentence denotes 2004)
T255 18214-18309 Sentence denotes HIV ARV naive Reported heroin use • ↓ MIP-1α, MIP-1β, MCP-2 in blood after stimulation with LPS
T256 18310-18366 Sentence denotes • ↑ CCR5 expression in CD4 cells Human (Meijerink et al.
T257 18367-18372 Sentence denotes 2015)
T258 18373-18434 Sentence denotes HIVE HIV No info OUD • ↑ Parenchymal inflammatory infiltrates
T259 18435-18511 Sentence denotes • ↑ HIV PCR amplification products Human, postmortem brain (Gosztonyi et al.
T260 18512-18517 Sentence denotes 1993)
T261 18518-18682 Sentence denotes Aberrant immune responses HIV No info SUD (opioids, alcohol, marijuana, cocaine) (+ OST) • ↑ Autoantibodies and delayed hypersensitivity to neural antigens OUD only
T262 18683-18733 Sentence denotes • No HIV effect/interaction Human (Jankovic et al.
T263 18734-18739 Sentence denotes 1991)
T264 18740-18833 Sentence denotes Learning-memory HIV 50-70% on cART Heroin, crack/cocaine • ↓ Total learning; ↓ Learning slope
T265 18834-18880 Sentence denotes • ↓ Delayed recall Human, female (Meyer et al.
T266 18881-18886 Sentence denotes 2013)
T267 18887-18933 Sentence denotes HIV cART Reported heroin use • ↓ Recall memory
T268 18934-18971 Sentence denotes • ↓ Working memory Human (Byrd et al.
T269 18972-18977 Sentence denotes 2011)
T270 18978-19056 Sentence denotes HIV No info SUD (opioids, alcohol, marijuana, cocaine) • ↓ Complex figure copy
T271 19057-19096 Sentence denotes • ↓ Delayed recall Human (Concha et al.
T272 19097-19102 Sentence denotes 1997)
T273 19103-19195 Sentence denotes Neuropsychological performance cART OST (methadone) No effect of OST Human (Applebaum et al.
T274 19196-19201 Sentence denotes 2010)
T275 19202-19351 Sentence denotes Cognitive function HIV cART OUD • ↓ Cognitive performance with anticholinergics, but not opioids, anxiolytics, or anticonvulsants Human (Rubin et al.
T276 19352-19357 Sentence denotes 2018)
T277 19358-19364 Sentence denotes Memory
T278 19365-19450 Sentence denotes Cognitive function HIV cART SUD (alcohol, cocaine, heroin) • ↓ Working memory in HIV+
T279 19451-19525 Sentence denotes • ↓ Spatial and verbal response times in women, irrespective of HIV status
T280 19526-19581 Sentence denotes • ↑ Response time with cocaine use Human (Martin et al.
T281 19582-19587 Sentence denotes 2018)
T282 19588-19715 Sentence denotes Visual and cognitive function HIV No info OUD (+ OST, methadone) • ↑ Pattern-shift visual evoked potential delay with methadone
T283 19716-19762 Sentence denotes • No HIV effect/interaction Human (Bauer 1998)
T284 19763-19865 Sentence denotes Transmission risk HIV No info OST ↓ Frequency of injection drug use Human (Kwiatkowski and Booth 2001)
T285 19866-19912 Sentence denotes HIV cART OST • ↓ Frequency of heroin injection
T286 19913-19944 Sentence denotes • ↑ On ARV Human (Pettes et al.
T287 19945-19950 Sentence denotes 2010)
T288 19951-20024 Sentence denotes Motor and visual function HIV No info OST • ↓ Digital Finger-Tapping test
T289 20025-20075 Sentence denotes • ↓ Visual motor pursuit Human (Silberstein et al.
T290 20076-20081 Sentence denotes 1993)
T291 20082-20173 Sentence denotes ARV adherence HIV cART OST • ↑ ARV adherence in PWH with OST vs. OUD Human (Mazhnaya et al.
T292 20174-20179 Sentence denotes 2018)
T293 20180-20248 Sentence denotes PENK expression HIV Pre- and post-cART SUD • ↓ PENK in HIVE vs. HIV−
T294 20249-20279 Sentence denotes • ↓ DRD2L HIV+ vs. HIVE & HIV−
T295 20280-20305 Sentence denotes • ↓ DRD2L correlates with
T296 20306-20369 Sentence denotes ↑ cognitive performance Human, post mortem brain (Gelman et al.
T297 20370-20375 Sentence denotes 2012)
T298 20376-20546 Sentence denotes OPRM1 polymorphisms, splice variants HIV No info SUD C17T MOR polymorphism correlates with ↑ risk of cocaine, alcohol & tobacco (but not opiate) use Human (Crystal et al.
T299 20547-20552 Sentence denotes 2012)
T300 20553-20655 Sentence denotes HIV cART No Some OPRM1 polymorphisms may alter HIV severity / response to ARV Human (Proudnikov et al.
T301 20656-20661 Sentence denotes 2012)
T302 20662-20710 Sentence denotes HIV No info MOR-1K expression • ↑ MOR-1K in HIVE
T303 20711-20814 Sentence denotes • ↑ CCL2, CCL6, CCL5, but not CXCR4, CCR5 or CD4 receptor in HIVE Human, postmortem brain (Dever et al.
T304 20815-20820 Sentence denotes 2014)
T305 20821-20959 Sentence denotes OPRK and PDYN polymorphisms HIV cART No Some OPRK and PDYN polymorphisms may alter HIV severity / response to ARV Human (Proudnikov et al.
T306 20960-20965 Sentence denotes 2013)
T307 20966-21093 Sentence denotes Sensory Neuropathy HIV cART SUD HIV sensory neuropathy- regardless of SUD (trends, not significant) Human (Robinson-Papp et al.
T308 21094-21099 Sentence denotes 2010)
T309 21100-21137 Sentence denotes Preclinical in vivo findings (animal)
T310 21138-21271 Sentence denotes HIV entry into the brain Mixture of SIV17-EFr, SHIVKU_1B, SHIV89.6P No Morphine (5 mg/kg i.m., b.i.d., ≤ 56 weeks) • ↑ CSF viral load
T311 21272-21344 Sentence denotes • ↑ Viral migration through BBB for SHIVKU Rhesus macaques (Kumar et al.
T312 21345-21350 Sentence denotes 2006)
T313 21351-21425 Sentence denotes SIVmacR71/17E No Morphine (3 mg/kg i.m., q.i.d.) • ↑ CD4+ and CD8+ T cells
T314 21426-21444 Sentence denotes • ↑ CSF viral load
T315 21445-21516 Sentence denotes • ↑ Infiltration of MDMs into the brain Rhesus macaques (Bokhari et al.
T316 21517-21523 Sentence denotes 2011).
T317 21524-21673 Sentence denotes Viral load and HIV progression Mixture of SIV17-EFr, SHIVKU _1B, SHIV89.6P No Morphine (5 mg/kg, i.m., t.i.d., 20 weeks) • ↑ Viral load; ↓ CD4 counts
T318 21674-21740 Sentence denotes • ↑ ROS with morphine + SIV Rhesus macaques (Perez-Casanova et al.
T319 21741-21768 Sentence denotes 2007; Perez-Casanova et al.
T320 21769-21774 Sentence denotes 2008)
T321 21775-21861 Sentence denotes SIV gene mutation/evolutiontat Mixture of SIV17-EFr, SHIVKU _1B, SHIV89.6P No Morphine
T322 21862-21927 Sentence denotes (5 mg/kg, i.m., t.i.d., 20–56 weeks) • ↑ Viral load; ↓ CD4 counts
T323 21928-21984 Sentence denotes • tat evolution—inverse correlation with SIV progression
T324 21985-22066 Sentence denotes • ↓ tat diversity with morphine Rhesus macaques (Noel and Kumar 2006; Noel et al.
T325 22067-22073 Sentence denotes 2006b)
T326 22074-22106 Sentence denotes nef • ↑ Viral load; ↓ CD4 counts
T327 22107-22185 Sentence denotes • ↓ nef evolution; no correlation with SIV progression ± morphine (Noel et al.
T328 22186-22192 Sentence denotes 2006a)
T329 22193-22225 Sentence denotes env • ↑ Viral load; ↓ CD4 counts
T330 22226-22298 Sentence denotes • ↑ env evolution (V4 region) correlates with SIV progression + morphine
T331 22299-22358 Sentence denotes • ↑ env evolution in CSF with morphine (Rivera-Amill et al.
T332 22359-22371 Sentence denotes 2007, 2010b)
T333 22372-22469 Sentence denotes vpr • ↓ vpr evolution and/or Vpr R50G mutation—inverse correlation with SIV progression/mortality
T334 22470-22537 Sentence denotes • ↓ vpr evolution with morphine (Noel and Kumar 2007; Rivera et al.
T335 22538-22543 Sentence denotes 2013)
T336 22544-22665 Sentence denotes Neuronal injury, survival, oxidative stress gp120 HIV-1LAV No Morphine (25 mg pellet, 5–7 days) • ↑ ROS during withdrawal
T337 22666-22705 Sentence denotes • ↓ PSD95 during chronic and withdrawal
T338 22706-22723 Sentence denotes • ↑ Sphingomyelin
T339 22724-22769 Sentence denotes • ↓ Ceramide Mouse, gp120 tgb (Bandaru et al.
T340 22770-22775 Sentence denotes 2011)
T341 22776-22883 Sentence denotes HIV No Morphine (37.5 mg s.c, 5 days) ↓ neuron survival HIV tg + morphine Rat, HIV-1 tg, female (Guo et al.
T342 22884-22889 Sentence denotes 2012)
T343 22890-22893 Sentence denotes SIV
T344 22894-23005 Sentence denotes HIV Tat No Morphine (3 mg/kg i.m., q.i.d., 3 weeks) • ↑ miR-29b, ↓ PDGF-B mRNA, ↑ PDGF-BB with morphine and SIV
T345 23006-23138 Sentence denotes • ↓ PDGF-B, ↓ neuron survival with CM from morphine-treated astrocytes Rhesus macaques; Ratb, primary neurons, astrocytes (Hu et al.
T346 23139-23144 Sentence denotes 2012)
T347 23145-23297 Sentence denotes Synaptic transmission Tat1–86 No Morphine ex vivo (1 μM) to the bath ↓ mIPSC frequency Mouse, male and female, PFC slices, ex vivo (Xu and Fitting 2016)
T348 23298-23311 Sentence denotes SIVmacR71/17E
T349 23312-23390 Sentence denotes Tat No info • Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., 12 months)
T350 23391-23441 Sentence denotes • Morphine in vitro • SIV ↑ Synaptic protein HSPA5
T351 23442-23488 Sentence denotes • Tat ↑ HSPA5 mRNA (in vitro) Rhesus macaques;
T352 23489-23495 Sentence denotes Human,
T353 23496-23549 Sentence denotes SH-SY5Y neuroblastoma cells in vitro (Pendyala et al.
T354 23550-23555 Sentence denotes 2015)
T355 23556-23670 Sentence denotes White matter effects SIVmacR71/17E No Morphine (3 mg/kg i.m., q.i.d., ≤ 59 weeks) • ↑ Focal, demyelinating lesions
T356 23671-23743 Sentence denotes • ↑ Macrophages in areas of myelin loss Rhesus macaques (Marcario et al.
T357 23744-23750 Sentence denotes 2008),
T358 23751-23865 Sentence denotes CNS metabolites SIVsmm9 No info Morphine (escalating doses of 1–3 mg/kg i.m., q.i.d., ≤ 4 years) • ↑ Survival time
T359 23866-23916 Sentence denotes • ↑ Creatine in white matter (SIV + morphine only)
T360 23917-23974 Sentence denotes • ↑ Myo-inositol in putamen Rhesus macaques (Cloak et al.
T361 23975-23980 Sentence denotes 2011)
T362 23981-24107 Sentence denotes Neuroinflammation Tat1–86 No Morphine (10 mg/kg i.p., b.i.d., 5 days) ↑ Iba1+ 3-NT+ microglia Mouse, Tat tg, males (Zou et al.
T363 24108-24113 Sentence denotes 2011)
T364 24114-24132 Sentence denotes Chemokines Tat1–72
T365 24133-24243 Sentence denotes (25 μg intrastriatal injection) No Morphine (25 mg pellet, 5 days) • ↑ CCL2 in astrocytes is regulated by CCR5
T366 24244-24277 Sentence denotes • ↑ CCL2 in macrophages/microglia
T367 24278-24362 Sentence denotes • CCL2-knockout blocks morphine + Tat-induced glial reactivity Mouse (El-Hage et al.
T368 24363-24369 Sentence denotes 2008a)
T369 24370-24502 Sentence denotes Cytokines, Chemokines HIV Tat (10 μg/kg i.v.) No Morphine (25, 75 mg pellet, 6 days) • Morphine ↑ death in Tat + bacterial infection
T370 24503-24524 Sentence denotes • ↑ TNFα, IL-6, CCL2,
T371 24525-24600 Sentence denotes • ↑ TLR2, TLR4, TLR9 Mouse, male, in vivo; microglia in vitro (Dutta et al.
T372 24601-24606 Sentence denotes 2012)
T373 24607-24695 Sentence denotes MOR expression HIV-1IIIB gp120 (X4) No MOR ↑ MOR mRNA Rats, HIV-1 tg males (Chang et al.
T374 24696-24701 Sentence denotes 2007)
T375 24702-24782 Sentence denotes MOR-coupling efficacy to G proteins Tat1–86 No • Morphine (acute, 10 mg/kg i.p.)
T376 24783-24946 Sentence denotes • Morphine, DAMGO (ex vivo) ↓ [35S]GTPγS binding in NAc Shell, CPu, amygdala, PFC, but not hippocampus, with morphine in Tat mice Mouse, Tat tg, males (Hahn et al.
T377 24947-24952 Sentence denotes 2016)
T378 24953-25149 Sentence denotes Neuroinflammation; morphine tolerance (antinociception), physical withdrawal, reward Tat1–86 No Morphine (75 mg pellet, 5 days) • ↑ Tolerance (↓ anti-nociceptive potency and ↓ withdrawal symptoms)
T379 25150-25195 Sentence denotes • ↑ CPP and cytokines (24 h after withdrawal)
T380 25196-25271 Sentence denotes • Above effects reduced by CCR5 blockade Mouse, Tat tg, males (Gonek et al.
T381 25272-25277 Sentence denotes 2018)
T382 25278-25396 Sentence denotes Neuropathy gp120 (0.2 μg), q.d. intrathecally No Morphine (3 μg, intrathecally, b.i.d., 5 days) • ↑ Mechanic allodynia
T383 25397-25446 Sentence denotes • ↑ Brd4 mRNA Rat, males, gp120 (Takahashi et al.
T384 25447-25452 Sentence denotes 2018)
T385 25453-25612 Sentence denotes Morphine efficacy, potency Tat1–86 No Morphine (acute, 2–8 mg/kg s.c.) ↓ Antinociceptive potency and efficacy (tail flick) Mouse, Tat tg, males (Fitting et al.
T386 25613-25618 Sentence denotes 2012)
T387 25619-25731 Sentence denotes Morphine tolerance, physical dependence Tat1–86 No Morphine (75 mg pellet, 4 days) • ↑ Antinociceptive tolerance
T388 25732-25792 Sentence denotes • ↓ Physical dependence Mouse, Tat tg, males (Fitting et al.
T389 25793-25798 Sentence denotes 2016)
T390 25799-25980 Sentence denotes Locomotor function Tat1–86 No Oxycodone (0–10 mg/kg, i.p., 15 min prior behavioral assay) ↑ Locomotor activity, center entries (open field) Mouse, Tat tg, females (Salahuddin et al.
T391 25981-25986 Sentence denotes 2020)
T392 25987-26116 Sentence denotes SIVmacR71/17E No Morphine (escalating doses of 1–2.5 mg/kg i.m., q.i.d., 59 weeks) ↓ Motor skill Rhesus macaques (Marcario et al.
T393 26117-26122 Sentence denotes 2016)
T394 26123-26230 Sentence denotes Tat1–86 No Oxycodone (acute, 0.1–10 mg/kg, i.p.) ↑ Psychomotor effects Mouse, Tat tg, females (Paris et al.
T395 26231-26236 Sentence denotes 2020)
T396 26237-26383 Sentence denotes BBB integrity Tat No Morphine (25 mg pellet, 5 days) ↑ Dextran extravasation across the blood-brain barrier Mouse, Tat tg females (Leibrand et al.
T397 26384-26389 Sentence denotes 2019)
T398 26390-26526 Sentence denotes Immune cell trafficking into CNS Tat No Morphine • ↑ Infiltration of monocytes and T cells into S. pneumoniae-infected CNS with morphine
T399 26527-26642 Sentence denotes • ↑ T cell CXCR4 and CCR5 expression with morphine Mouse, CNS infection (S. pneumoniae), males (Dutta and Roy 2015)
T400 26643-26667 Sentence denotes ARV accumulation Tat DTG
T401 26668-26671 Sentence denotes ABC
T402 26672-26857 Sentence denotes 3TC Morphine (2 mg/day, s.c.. osmotic pump, 5 days) ↓ Dolutegravir and abacavir, but no change in lamivudine in brains of morphine-treated animals Mouse, Tat tg females (Leibrand et al.
T403 26858-26863 Sentence denotes 2019)
T404 26864-26996 Sentence denotes Circadian rhythms Tat1–86 No Morphine (25 mg pellet, last 5 days) ↓ Total wheel-running activity Mouse, Tat tg, males (Duncan et al.
T405 26997-27002 Sentence denotes 2008)
T406 27003-27116 Sentence denotes aassumed Clade B, unless noted otherwise; b sex not reported; c authors reported a trend that was not significant
T407 27117-28163 Sentence denotes ABC, abacavir; ARV, antiretroviral(s); BBB, blood-brain barrier; b.i.d., twice a day; Brd4, Bromodomain-containing protein 4; CPu, caudate-putamen; CNS, central nervous system; CPP, conditioned place preference; CM, conditioned medium; CSF, cerebrospinal fluid; DAMGO [D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DRD2L, type 2 dopamine receptor; DTG, dolutegravir; HIVE, HIV encephalitis (typically seen pre-cART); HSPA5, heat shock 70-kDa protein A 5; IDU, injection drug use; i.m., intramuscularly; i.p., intraperitoneal; Iba1, ionized calcium-binding adapter molecule 1; 3TC, lamivudine; MHC class II, major histocompatibility class II; mIPSC, miniature inhibitory postsynaptic currents; MOR, μ-opioid receptor; No info, information not provided or uncertain; OST, opioid substitution therapy; OUD, opioid use disorder; PFC, prefrontal cortex; PENK, preproenkephalin; q.d., once a day; q.i.d., four times a day; ROS, reactive oxygen species; s.c., subcutaneous; SUD, substance use disorder; tg, transgenic; t.i.d., three times a day; ZDV, zidovudine
T408 28164-28319 Sentence denotes For practicality, Tables 1 and 2 are limited to key studies in the CNS with emphasis on neuropathological or neuroimmune rather than psychosocial outcomes.
T409 28320-28764 Sentence denotes With deference toward the excellent studies we excluded: (1) on opioid and HIV effects on peripheral blood mononuclear cells (PBMCs), or on isolated lymphocytes and monocytes, not directly related to the central nervous system or BBB; (2) on HIV or opioid and ARV interactions in the peripheral nervous system; and (3) studies not directly examining opioid-HIV interactions (irrespective of whether a positive or negative interaction was found)
T410 28765-28996 Sentence denotes Although translational, “bench-to-bedside”, research is important, reverse-translational approaches and multiple preclinical models are essential to better understand complex disease and improve established therapies (Singer 2019).
T411 28997-29181 Sentence denotes Evidence suggests that HIV compartmentalizes within the CNS early during the course of the infection establishing a separate reservoir harboring “intact proviral” HIV (Churchill et al.
T412 29182-29201 Sentence denotes 2016; Bruner et al.
T413 29202-29262 Sentence denotes 2019) within resident neural cell populations (Bednar et al.
T414 29263-29286 Sentence denotes 2015; Sturdevant et al.
T415 29287-29308 Sentence denotes 2015; Veenhuis et al.
T416 29309-29365 Sentence denotes 2019) and perivascular macrophages (Fischer-Smith et al.
T417 29366-29384 Sentence denotes 2001; Burdo et al.
T418 29385-29418 Sentence denotes 2013; Rappaport and Volsky 2015).
T419 29419-29719 Sentence denotes Preclinical studies assessing opioid interactions with HIV or viral proteins permit mechanistic understanding of how particular CNS cell types, including neurons, astroglia, and microglia are affected and contribute to accentuating effects of opiates on neuroHIV, which are discussed in detail below.
T420 29721-29793 Sentence denotes Cellular and Molecular Interactions in Astroglia, Microglia, and Neurons
T421 29794-29910 Sentence denotes Prior reviews have outlined how opiate drugs likely exacerbate neuroHIV pathology in neurons and glia (Hauser et al.
T422 29911-29950 Sentence denotes 2005; Dutta and Roy 2012; Hauser et al.
T423 29951-29969 Sentence denotes 2012; Reddy et al.
T424 29970-30009 Sentence denotes 2012; Hauser and Knapp 2014; Liu et al.
T425 30010-30030 Sentence denotes 2016a; Murphy et al.
T426 30031-30104 Sentence denotes 2019) including in the enteric nervous system (Galligan 2015; Meng et al.
T427 30105-30111 Sentence denotes 2015).
T428 30112-30401 Sentence denotes Opioid-HIV pathophysiological interactions are complex and differ depending on the timing and duration of co-exposure, the pharmacology of the opioid drug involved, the cell types and brain regions targeted, host and viral genetics, and are highly contextual (Hauser and Knapp 2014, 2018).
T429 30402-30519 Sentence denotes A summary of the cellular and molecular interactions in various CNS cell types is also reviewed in detail in Table 2.
T430 30520-30574 Sentence denotes Table 2 Cellular and molecular interactions (in vitro)
T431 30575-30658 Sentence denotes Major effects HIV pathogena ARV Opioids Outcome Model system (in vitro) Citation(s)
T432 30659-30669 Sentence denotes Mixed-Glia
T433 30670-30703 Sentence denotes HIV expression HIV No • Dynorphin
T434 30704-30713 Sentence denotes • U50,488
T435 30714-30750 Sentence denotes (KOR agonists) • ↑ HIV-1 expression,
T436 30751-30881 Sentence denotes • Dynorphin (KOR agonist) ↑ TNF-α, IL-6 mRNA and protein Human fetal neural cells, HIV-infected promonocyte (U1) line (Chao et al.
T437 30882-30887 Sentence denotes 1995)
T438 30888-30909 Sentence denotes HIVSF162 No • U50,488
T439 30910-30919 Sentence denotes • U69,593
T440 30920-30936 Sentence denotes • Dynorphin1–17;
T441 30937-30951 Sentence denotes (KOR agonists)
T442 30952-31061 Sentence denotes • Morphine • KOR agonists ± TNF-α differentially ↓ HIV p24 Human, primary mixed neurons and glia (Chao et al.
T443 31062-31068 Sentence denotes 1998a)
T444 31069-31114 Sentence denotes Chemokines Tat1–86 No Morphine • ↑ CCL5, CCL2
T445 31115-31146 Sentence denotes • ↑ [Ca2+]i (Beclin1 dependent)
T446 31147-31203 Sentence denotes • ↓ Autophagy Mouse, primary mixed glia (Lapierre et al.
T447 31204-31209 Sentence denotes 2018)
T448 31210-31272 Sentence denotes HIVSF162 (R5) No Morphine • ↑ HIV-1 Tat-induced LTR expression
T449 31273-31337 Sentence denotes • ↑ CCR5 expression (inhibited by bivalent ligand in astrocytes)
T450 31338-31346 Sentence denotes • ↑ IL-6
T451 31347-31397 Sentence denotes • ↑ CCL5 Human, primary mixed glia (El-Hage et al.
T452 31398-31403 Sentence denotes 2013)
T453 31404-31588 Sentence denotes Glial restricted precursors: survival & MOR, DOR, KOR expression Tat1–72 No Morphine (acting via DOR and/or KOR) • ↑ Caspase-3 activation & ↑ cell death by Tat or morphine via DOR, KOR
T454 31589-31662 Sentence denotes • No opioid-Tat interactions Mouse, primary glial precursors (Buch et al.
T455 31663-31668 Sentence denotes 2007)
T456 31669-31692 Sentence denotes MOR expression in NPCs;
T457 31693-31783 Sentence denotes NPC survival and developmental fate Tat1–72 No Morphine • MOR expressed by subsets of NPCs
T458 31784-31866 Sentence denotes • ↑ Astrocyte and immature glial death Mouse, primary mixed glia (Khurdayan et al.
T459 31867-31872 Sentence denotes 2004)
T460 31873-32055 Sentence denotes MOR and CCR5 interactions Tat1–86 (from HIVIIIB) No Morphine • ↓ Neuronal survival via CCR5 activation in glia (rescued by BDNF treatment) Mouse, primary neurons and glia (Kim et al.
T461 32056-32061 Sentence denotes 2018)
T462 32062-32125 Sentence denotes HIV infectivity MOR-CCR5 dimerization HIVSF162 (R5) No Morphine
T463 32126-32248 Sentence denotes CCR5-MOR bivalent ligand 1b • MOR-CCR5 bivalent ligand blocks HIV infection in astroglia, but not microglia, with morphine
T464 32249-32409 Sentence denotes • MOR-CCR5 bivalent ligand blocks the fusion of HIV gp160 and CCR5-CD4-expressing HEK cells Human, primary astrocytes and microglia; HEK-293T cells (Yuan et al.
T465 32410-32429 Sentence denotes 2013; Arnatt et al.
T466 32430-32435 Sentence denotes 2016)
T467 32436-32583 Sentence denotes HIV expression and maturational fate of neurons and astroglia HIVBaL (R5) No Morphine • ↑ HIV p24 and ↑ Tat mRNA levels with morphine after 21 days
T468 32584-32711 Sentence denotes • ↓ Proliferation of neural progenitors; ↑ astroglial and ↑ neuronal differentiation Human, neural progenitors (Balinang et al.
T469 32712-32717 Sentence denotes 2017)
T470 32718-32728 Sentence denotes Astrocytes
T471 32729-32781 Sentence denotes HIV expression HIVSF162 (R5) No Morphine • ↑ HIV p24
T472 32782-32834 Sentence denotes • ↑ CCL2 Human, primary astrocytes (Rodriguez et al.
T473 32835-32840 Sentence denotes 2017)
T474 32841-32895 Sentence denotes Toll-like receptor (TLR) expression/function • Tat1–72
T475 32896-32956 Sentence denotes • gp120 No Morphine • ↑ TLR2 with Tat, Tat + morphine, gp120
T476 32957-33033 Sentence denotes • ↓ TLR9 with Tat, morphine, gp120 Mouse, primary astrocytes (El-Hage et al.
T477 33034-33040 Sentence denotes 2011a)
T478 33041-33086 Sentence denotes Chemokines Tat1–72 No Morphine • ↑ CCL5, CCL2
T479 33087-33095 Sentence denotes • ↑ IL-6
T480 33096-33149 Sentence denotes • ↑ [Ca2+]i Mouse, primary astrocytes (El-Hage et al.
T481 33150-33155 Sentence denotes 2005)
T482 33156-33184 Sentence denotes Tat1–72 No Morphine • ↑ CCL2
T483 33185-33193 Sentence denotes • ↑ CCL5
T484 33194-33260 Sentence denotes • ↑ Microglial migration Mouse, primary astrocytes (El-Hage et al.
T485 33261-33267 Sentence denotes 2006a)
T486 33268-33313 Sentence denotes Tat1–72 No Morphine • ↑ CCL2, ↑ IL-6, ↑ TNF-α
T487 33314-33325 Sentence denotes • ↑ [Ca2+]i
T488 33326-33365 Sentence denotes • ↑ NF-κB trafficking and transcription
T489 33366-33453 Sentence denotes • No interaction / acceleration with morphine Mouse, primary astrocytes (El-Hage et al.
T490 33454-33460 Sentence denotes 2008b)
T491 33461-33491 Sentence denotes Tat No • U50,488 (KOR agonist)
T492 33492-33535 Sentence denotes • Nor-BNI (KOR antagonist) • U50,488 ↓ CCL2
T493 33536-33593 Sentence denotes • U50,488 ↓ NF-κB Human, primary astrocytes (Sheng et al.
T494 33594-33599 Sentence denotes 2003)
T495 33600-33637 Sentence denotes N/A No Morphine • ↑ CCR5, CCR3, CXCR2
T496 33638-33721 Sentence denotes • ↓ IL-8, CCL4 Human, astrocytoma U87 cell line, primary astrocytes (Mahajan et al.
T497 33722-33727 Sentence denotes 2002)
T498 33728-33737 Sentence denotes • Tat1–86
T499 33738-33881 Sentence denotes • gp120IIIB No Morphine Regional differences in cytokine and ROS production —differed for each insult Mouse, primary astrocytes (Fitting et al.
T500 33882-33888 Sentence denotes 2010a)
T501 33889-33933 Sentence denotes Oxidative stress / damage Tat1–72 No • DPDPE
T502 33934-33942 Sentence denotes • SNC-80
T503 33943-34057 Sentence denotes (DOR agonists) DOR agonists ↓ Tat-induced oxidative stress Human derived brain cell line (SK-N-SH) (Wallace et al.
T504 34058-34063 Sentence denotes 2006)
T505 34064-34108 Sentence denotes Inflammation, maturation /plasticity • Tat86
T506 34109-34270 Sentence denotes • Tat101 No Morphine ↓ β-catenin signaling and variably decreases TrkB, BDNF, and NLRP1 mRNA in fetal astrocytes b Human, U87MG and fetal astrocytes (Chen et al.
T507 34271-34276 Sentence denotes 2020)
T508 34277-34286 Sentence denotes Microglia
T509 34287-34335 Sentence denotes HIV replication HIVSF162 (R5) No • Endomorphin-1
T510 34336-34351 Sentence denotes • Endomorphin-2
T511 34352-34420 Sentence denotes (MOR agonists) • ↑ HIV p24 with endomorphin-1, but not endomorphin-2
T512 34421-34510 Sentence denotes • Endomorphin-1 acts via MOR, but not DOR / KOR Human, primary microglia (Peterson et al.
T513 34511-34516 Sentence denotes 1999)
T514 34517-34593 Sentence denotes HIVSF162 (R5) No Morphine ↑ HIV p24 Human, primary microglia (El-Hage et al.
T515 34594-34599 Sentence denotes 2014)
T516 34600-34650 Sentence denotes HIVSF162 (R5) No • U50,488; U69,593 (KOR agonists)
T517 34651-34716 Sentence denotes • Dynorphin Al-13 ↓ HIV p24 Human, primary microglia (Chao et al.
T518 34717-34723 Sentence denotes 1996b)
T519 34724-34739 Sentence denotes • HIVJR-FL (R5)
T520 34740-34781 Sentence denotes • gp120 No β-endorphin • ↑ HIV expression
T521 34782-34817 Sentence denotes • ↑ HIV p24 (14-day post infection)
T522 34818-34881 Sentence denotes • gp120 ↑ IL-1, TNF, IL-6 Human, fetal microglia (Sundar et al.
T523 34882-34887 Sentence denotes 1995)
T524 34888-34931 Sentence denotes HIVSF162 No • 8-CAC, U50,488 (KOR agonists)
T525 34932-34989 Sentence denotes • Cocaine • KOR agonist ↓ p24; blocked by KOR antagonists
T526 34990-35077 Sentence denotes • KOR agonist negates cocaine-induced ↑ HIV Human, fetal brain microglia (Gekker et al.
T527 35078-35083 Sentence denotes 2004)
T528 35084-35111 Sentence denotes HIVSF162 No OPRL1 antisense
T529 35112-35188 Sentence denotes Nociceptin / orphanin FQ (OPRL1 agonist) • OPRL1 antisense (and sense) ↓ p24
T530 35189-35284 Sentence denotes • Nociceptin, no effect on p24 Human, fetal brain microglia and mixed neurons/glia (Chao et al.
T531 35285-35291 Sentence denotes 1998b)
T532 35292-35317 Sentence denotes HIV expression • HIVSF162
T533 35318-35380 Sentence denotes • Tat ZDV U50,488 (KOR agonist) • ↓ p24 on day 14 with U50,488
T534 35381-35408 Sentence denotes • ↓ Neurotoxicity (U50,488)
T535 35409-35490 Sentence denotes • ↓ Quinolinate by microglia Human, fetal microglia and neural cells (Chao et al.
T536 35491-35496 Sentence denotes 2000)
T537 35497-35550 Sentence denotes Chemokines and Cytokines Tat1–72 No Morphine • ↑ CCR5
T538 35551-35568 Sentence denotes • ↑ CD11b, ↑ CD40
T539 35569-35595 Sentence denotes • ↑ TNF-α, ↑ IL-6, ↑ IP-10
T540 35596-35654 Sentence denotes • ↑ iNOS Mouse, BV-2 and primary microglia (Bokhari et al.
T541 35655-35660 Sentence denotes 2009)
T542 35661-35718 Sentence denotes MOR signaling Tat1–72 No Morphine • ↑ MOR (intracellular)
T543 35719-35787 Sentence denotes • ↑ MOR mRNA Mouse, N9 and primary microglia (Turchan-Cholewo et al.
T544 35788-35793 Sentence denotes 2008)
T545 35794-35870 Sentence denotes Oxidative Stress Tat1–72 No Morphine • ↑ ROS [O2− (DHE), ↑ HO2•, H2O2 (DCF)]
T546 35871-35948 Sentence denotes • ↑ Protein carbonyls Mouse, N9 and primary microglia (Turchan-Cholewo et al.
T547 35949-35954 Sentence denotes 2009)
T548 35955-36110 Sentence denotes Glutamate release Tat1–72 No Morphine ↑ Glutamate release via ↑ xc− cystine-glutamate antiporter expression/function Mouse, primary microglia (Gupta et al.
T549 36111-36116 Sentence denotes 2010)
T550 36117-36124 Sentence denotes Neurons
T551 36125-36231 Sentence denotes HIV expression HIV No Morphine ↑ HIV expression Human derived, SH-SY5Y neuroblastoma cells (Squinto et al.
T552 36232-36237 Sentence denotes 1990)
T553 36238-36293 Sentence denotes Homeostasis and Injury Tat1–86 No Morphine • ↑ [Ca2+]i,
T554 36294-36304 Sentence denotes • ↑ [Na+]i
T555 36305-36340 Sentence denotes • ↓ ΔΨm (mitochondrial) instability
T556 36341-36406 Sentence denotes • ↑ Dendritic degeneration Mouse, primary neurons (Fitting et al.
T557 36407-36413 Sentence denotes 2014a)
T558 36414-36479 Sentence denotes Mitochondrial inner membrane potential and ROS • Tat1–86, Tat1–72
T559 36480-36754 Sentence denotes • gp120 No Morphine ↑ ΔΨm instability and oxidative stress ↑ with Tat + morphine, ↑ neuroprotection with allopregnanolone Human, primary neurons ; mouse, striatal medium spiny neurons; mouse, striatal medium spiny neurons, SH-SY5Y neuroblastoma cells (Turchan-Cholewo et al.
T560 36755-36773 Sentence denotes 2006; Paris et al.
T561 36774-36779 Sentence denotes 2020)
T562 36780-36895 Sentence denotes Neuronal survival Tat1–86 No Morphine • ↓ Neuronal survival from Tat + morphine and ↓ glial CX3CL1 rescued by CX3CL
T563 36896-37001 Sentence denotes • CX3CL1 (fractalkine) regulates microglial motility Mouse, primary neurons and mixed glia (Suzuki et al.
T564 37002-37007 Sentence denotes 2011)
T565 37008-37045 Sentence denotes Tat1–86 No Morphine • ↓ Proliferation
T566 37046-37067 Sentence denotes • ↑ ERK1/2 activation
T567 37068-37083 Sentence denotes • ↑ p53 and p21
T568 37084-37153 Sentence denotes • ↓ Cyclin D1 and Akt levels Human, neuronal precursors (Malik et al.
T569 37154-37159 Sentence denotes 2014)
T570 37160-37210 Sentence denotes Tat1–72, Tat1–86 No Morphine • ↓ Neuronal survival
T571 37211-37370 Sentence denotes • ↑ Neuronal survival with ibudilast (AV411) (inhibiting glial NF-κB blocks Tat ± morphine neurotoxicity) Mouse, primary neurons and mixed glia (Gurwell et al.
T572 37371-37391 Sentence denotes 2001; El-Hage et al.
T573 37392-37397 Sentence denotes 2014)
T574 37398-37437 Sentence denotes White matter/oligodendroglial pathology
T575 37438-37563 Sentence denotes Changes in OL survival and morphology Tat1–86 No Morphine (25 mg pellet, 7 days); morphine (in vitro) • ↑ Degeneration of OLs
T576 37564-37584 Sentence denotes • ↑ TUNEL reactivity
T577 37585-37651 Sentence denotes • ↑ Caspase-3 activation Mouse, Tat tg; primary OLs (Hauser et al.
T578 37652-37657 Sentence denotes 2009)
T579 37658-37704 Sentence denotes Blood-brain barrier and the neurovascular unit
T580 37705-37767 Sentence denotes BBB model integrity and function Tat1–86 No Morphine • ↑ TNF-α
T581 37768-37776 Sentence denotes • ↑ IL-8
T582 37777-37784 Sentence denotes • ↓TEER
T583 37785-37805 Sentence denotes • ↑ JAM-2 expression
T584 37806-37909 Sentence denotes • ↑ Monocyte transmigration with CCL5 Human, using primary BMVEC and primary astrocytes (Mahajan et al.
T585 37910-37915 Sentence denotes 2008)
T586 37916-37944 Sentence denotes ARV accumulation Tat1–86 DTG
T587 37945-37948 Sentence denotes FTC
T588 37949-38038 Sentence denotes TFV Morphine • ↓ Intracellular ARV concentrations Human, primary astrocytes (Patel et al.
T589 38039-38044 Sentence denotes 2019)
T590 38045-38069 Sentence denotes HIV-1 strain differences
T591 38070-38166 Sentence denotes Neuronal Survival Tat1–86 (clades B & C) No Morphine • ↓ Neuronal survival via MOR on mixed glia
T592 38167-38188 Sentence denotes • ↑ ROS in astrocytes
T593 38189-38280 Sentence denotes • ↑ Iba1 and 3-NT microglia with morphine Mouse, primary neurons and mixed glia (Zou et al.
T594 38281-38286 Sentence denotes 2011)
T595 38287-38298 Sentence denotes • gp120IIIB
T596 38299-38313 Sentence denotes • gp120MN (X4)
T597 38314-38537 Sentence denotes • gp120ADA (R5) No Morphine ↓ Neuronal survival in presence of glia with gp120MN and transiently with gp120IIIB (X4), not R5-tropic gp120, in combination with morphine Mouse, primary neurons and mixed glia (Podhaizer et al.
T598 38538-38543 Sentence denotes 2012)
T599 38544-38637 Sentence denotes Proliferation and maturational fate of neural progenitors and oligodendroglia • HIVSF162 (R5)
T600 38638-38740 Sentence denotes • HIVIIIB (X4) No Morphine • ↓ Proliferation of immature neural and OL progenitors with Tat + morphine
T601 38741-38792 Sentence denotes • ↓ NPC DNA synthesis with R5-tropic HIV + morphine
T602 38793-38913 Sentence denotes • ↑ NPC DNA synthesis with X4-tropic HIV + morphine Mouse, Tat tg; Mouse, Human, primary neural progenitors (Hahn et al.
T603 38914-38919 Sentence denotes 2012)
T604 38920-38947 Sentence denotes GABA function • HIVBaL (R5)
T605 38948-38975 Sentence denotes • gp120 (ADA, MN, and IIIB)
T606 38976-39038 Sentence denotes • Tat1–86 No Morphine • Tat or morphine ↓ KCC2 levels via CCR5
T607 39039-39168 Sentence denotes • ↑ KCC2 prevents Tat and R5 HIV, gp120, but not X4, gp120 neurotoxicity ± morphine Human, primary neurons, hNPCs (Barbour et al.
T608 39169-39174 Sentence denotes 2020)
T609 39175-39227 Sentence denotes Astroglial CCL5 and neuroprotection • gp120IIIB (X4)
T610 39228-39265 Sentence denotes • gp120BaL (R5) No • Morphine (10 μM)
T611 39266-39334 Sentence denotes • DAMGO • Morphine ↑ astroglial CCL5 blocking gp120BaL neurotoxicity
T612 39335-39486 Sentence denotes • Morphine (or CXCL12) does not block gp120IIIB neurotoxicity Rat, mixed neurons and glia; isolated neurons, astrocytes and microglia (Avdoshina et al.
T613 39487-39492 Sentence denotes 2010)
T614 39493-39586 Sentence denotes aassumed Clade B, unless noted otherwise, b statistical findings for some results are unclear
T615 39587-40497 Sentence denotes ARV, antiretroviral(s); BMVEC, brain vascular endothelial cells; [Ca2+]i intracellular calcium concentration; 8-CAC, 8-carboxamidocyclazocine; DAMGO, D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DCF, dihydro-dichlorofluorescein; DOR, δ-opioid receptor; DHE, dihydroethidium; DTG, dolutegravir; DPDPE, [D-Pen2,D-Pen5]enkephalin; FTC, emtricitabine; GABA, γ-aminobutyric acid; Iba1, ionized calcium-binding adapter molecule 1; JAM-1, junctional adhesion molecule-1; KCC2, K+-Cl− cotransporter 2; KOR, κ-opioid receptor; LTR, long terminal repeat; ΔΨm, mitochondrial inner membrane potential; MOR, μ-opioid receptor; [Na+]i, intracellular sodium concentration; nor-BNI, nor-binaltorphimine; NPCs, neural progenitor cells; OLs, oligodendroglia; ROS, reactive oxygen species; TEER, transendothelial electrical resistance; TFV, tenofovir; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; ZDV, zidovudine
T616 40498-40647 Sentence denotes For practicality, the table is limited to key studies in the CNS with emphasis on neuropathological or neuroimmune rather than psychosocial outcomes.
T617 40648-41055 Sentence denotes With deference toward the excellent studies we excluded: (1) on opioid and HIV effects on PBMCs, or on isolated lymphocytes and monocytes, not directly related to the central nervous system or BBB; (2) on HIV or opioid and ARV interactions in the peripheral nervous system; and (3) studies not directly examining opioid-HIV interactions (irrespective of whether a positive or negative interaction was found)
T618 41057-41106 Sentence denotes Opioid and HIV Interactive Pathology in Astroglia
T619 41107-41201 Sentence denotes Although the extent to which astroglia display productive infection is debated (Russell et al.
T620 41202-41217 Sentence denotes 2017; Ko et al.
T621 41218-41324 Sentence denotes 2019), there is nevertheless considerable evidence of proviral integration in the CNS of PWH (Gorry et al.
T622 41325-41347 Sentence denotes 2003; Churchill et al.
T623 41348-41395 Sentence denotes 2009), infectious animal models (Eugenin et al.
T624 41396-41459 Sentence denotes 2011), and/or cultured human fetal astrocytes (Tornatore et al.
T625 41460-41476 Sentence denotes 1994; Liu et al.
T626 41477-41492 Sentence denotes 2004; Do et al.
T627 41493-41516 Sentence denotes 2014; Narasipura et al.
T628 41517-41532 Sentence denotes 2014; Li et al.
T629 41533-41559 Sentence denotes 2015; Nath 2015; Li et al.
T630 41560-41566 Sentence denotes 2020).
T631 41567-41704 Sentence denotes Integrated HIV sequences have been identified in astrocytes in HIV-infected CNS tissue by laser capture microdissection (Churchill et al.
T632 41705-41711 Sentence denotes 2006).
T633 41712-41870 Sentence denotes Astroglia appear to infect via non-classical, CD4-independent mechanisms, that can have the appearance of virologic synapses, adding to the debate (Liu et al.
T634 41871-41886 Sentence denotes 2004; Do et al.
T635 41887-41902 Sentence denotes 2014; Li et al.
T636 41903-41936 Sentence denotes 2015; Nath 2015; Al-Harthi et al.
T637 41937-41952 Sentence denotes 2019; Li et al.
T638 41953-41959 Sentence denotes 2020).
T639 41960-42206 Sentence denotes Irrespective of whether they become infected, MOR-expressing, HIV or HIV protein-exposed astrocytes release greater amounts of inflammatory cytokines and dysfunction sufficient to harm bystander neurons upon treatment with opiates (El-Hage et al.
T640 42207-42230 Sentence denotes 2005, 2008b; Zou et al.
T641 42231-42251 Sentence denotes 2011; El-Hage et al.
T642 42252-42258 Sentence denotes 2014).
T643 42259-42415 Sentence denotes MOR-expressing subsets of glia, especially microglia and astroglia, are prominent in driving the interactive opioid and HIV neuropathogenesis (Hauser et al.
T644 42416-42461 Sentence denotes 2007, 2012; Hauser and Knapp 2014; Liu et al.
T645 42462-42484 Sentence denotes 2016a; Chilunda et al.
T646 42485-42504 Sentence denotes 2019; Murphy et al.
T647 42505-42511 Sentence denotes 2019).
T648 42512-42672 Sentence denotes When MOR is deleted from glia (astrocytes and microglia), morphine no longer increases the death of Tat-exposed striatal medium spiny neurons (MSNs) (Zou et al.
T649 42673-42679 Sentence denotes 2011).
T650 42680-42791 Sentence denotes Conversely, if MOR is deleted from MSNs, morphine exacerbates the neurotoxic effects of Tat in MSNs (Zou et al.
T651 42792-42798 Sentence denotes 2011).
T652 42799-42957 Sentence denotes The proinflammatory effects of Tat alone or in combination with morphine on glia are mediated through a Beclin-1-dependent autophagy pathway (Rodriguez et al.
T653 42958-42979 Sentence denotes 2017; Lapierre et al.
T654 42980-42986 Sentence denotes 2018).
T655 42987-43220 Sentence denotes Drugs with selective glial anti-inflammatory activity (i.e., ibudilast or AV411) attenuated the deleterious effects of HIV and opiate exposure, including HIV-1 replication, cytokine release, and neurotoxicity in vitro (El-Hage et al.
T656 43221-43227 Sentence denotes 2014).
T657 43228-43316 Sentence denotes Thus, the observed neuronal death is largely mediated by MOR-expressing glia (Zou et al.
T658 43317-43359 Sentence denotes 2011), including astroglia (El-Hage et al.
T659 43360-43410 Sentence denotes 2005, 2008b) and microglia (Turchan-Cholewo et al.
T660 43411-43431 Sentence denotes 2008; Bokhari et al.
T661 43432-43460 Sentence denotes 2009; Turchan-Cholewo et al.
T662 43461-43479 Sentence denotes 2009; Gupta et al.
T663 43480-43486 Sentence denotes 2010).
T664 43487-43622 Sentence denotes The direct contributions of astrocytes to opioid and HIV interactions have been discussed previously (Dutta and Roy 2012; Hauser et al.
T665 43623-43641 Sentence denotes 2012; Reddy et al.
T666 43642-43671 Sentence denotes 2012; Hauser and Knapp 2014).
T667 43672-43769 Sentence denotes Subsets of astroglia can express MOR, DOR and KOR (Stiene-Martin and Hauser 1991; Eriksson et al.
T668 43770-43790 Sentence denotes 1992; Ruzicka et al.
T669 43791-43811 Sentence denotes 1995; Gurwell et al.
T670 43812-43831 Sentence denotes 1996; Hauser et al.
T671 43832-43853 Sentence denotes 1996; Peterson et al.
T672 43854-43880 Sentence denotes 1998; Stiene-Martin et al.
T673 43881-43946 Sentence denotes 1998, 2001), as well as endogenous opioid peptides (Vilijn et al.
T674 43947-43967 Sentence denotes 1988; Shinoda et al.
T675 43968-43987 Sentence denotes 1989; Spruce et al.
T676 43988-44007 Sentence denotes 1990; Hauser et al.
T677 44008-44024 Sentence denotes 1990; Low et al.
T678 44025-44031 Sentence denotes 1992).
T679 44032-44215 Sentence denotes It appears that the ‘early’ events triggering the release of proinflammatory cytokines (i.e., TNF-α and IL-1β) from astroglia can be mediated by HIV Tat exposure alone (El-Hage et al.
T680 44216-44239 Sentence denotes 2005, 2006a, b, 2008a).
T681 44240-44521 Sentence denotes Opioids enhance HIV-1-induced inflammation later during the inflammatory cascade by exacerbating the sustained release of CCL5 from astrocytes, which subsequently triggers the release of CCL2 thereby enhancing the recruitment and activation of macrophages/microglia (El-Hage et al.
T682 44522-44538 Sentence denotes 2008a) (Fig. 1).
T683 44539-44695 Sentence denotes This is caused by the morphine-dependent exacerbation of Tat-induced increases in intracellular calcium concentration ([Ca2+]i) in astroglia (El-Hage et al.
T684 44696-44859 Sentence denotes 2005), which accelerates the trafficking of NF-κB p65 (RelA) subunits to the nucleus and sustained CCL2, CCL5, and IL-6 transcription in astrocytes (El-Hage et al.
T685 44860-44867 Sentence denotes 2008b).
T686 44868-45071 Sentence denotes Fig. 1 Opioids exacerbate HIV-1-induced CNS inflammation, in part, by augmenting CCL5-dependent increases in CCL2—key sites of opioid-HIV convergent interactions in glial inflammatory signaling cascades.
T687 45072-45346 Sentence denotes Subpopulations of striatal glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in wildtype mice normally express CCR2 immunoreactivity (a-b; arrows), CCL2 (c; arrow), or μ-opioid receptor (MOR) (d; arrows) immunoreactivity (scale bars a-b = 25 μm; c-d = 15 μm).
T688 45347-45627 Sentence denotes CCR2 deletion (−/−) significantly reduces HIV-1 Tat ± morphine-induced increases in GFAP+ astroglia (e) and F4/80+ macrophages/microglia (f) compared to wild type (+/+) mice at sites near (300 ± 100 μm) the site of Tat injection (*p < 0.05 vs. wild type mice) (see, El-Hage et al.
T689 45628-45635 Sentence denotes 2006a).
T690 45636-46184 Sentence denotes In wild-type mice, Tat ± morphine administration markedly increases the proportion of CCL2 immunoreactive astrocytes (g) or macrophages/microglia (h) [*p < 0.05 vs. other groups in wild-type or CCL5(−/−) mice; bp < 0.05 vs. vehicle- or Tat plus morphine-treated wild-type mice; #p < 0.05 vs. equivalent treatment in wild-type mice], while in CCL5 null mice, significant increases in CCL2 immunoreactivity were only seen in macrophages/microglia co-exposed to Tat and morphine (§p < 0.05 vs. vehicle injected CCL5 knockout mice) (see, El-Hage et al.
T691 46185-46192 Sentence denotes 2008a).
T692 46193-46365 Sentence denotes CCL5 expression in striatal GFAP-immunoreactive astrocytes (arrows) increases following Tat injections (i, j) compared to wild-type control mice (not shown) (El-Hage et al.
T693 46366-46373 Sentence denotes 2008a).
T694 46374-46626 Sentence denotes Opioids exacerbate HIV-1-induced CNS inflammation, in part, by increasing CCL5 and augmenting CCR5-dependent increases in CCL2 production by astrocytes resulting in the activation and recruitment of microglia/macrophages and spiraling inflammation (k).
T695 46627-46732 Sentence denotes Additional factors likely mediate the proinflammatory cascade, but these are less well substantiated (?).
T696 46733-47148 Sentence denotes Moreover, autocrine and reciprocal paracrine (astroglial ↔ macrophage/microglial) intercellular, feedback amplification mechanisms from macrophages/microglia are likely to be operative (dashed red arrow) (also see, Kang and Hebert 2011) and occur elsewhere within the cascade (not shown); effects of HIV-1 Tat/HIV, red arrows; sites of opioid convergence, blue arrows; pro-BDNF:mature BDNF (mBDNF) ratio (Kim et al.
T697 47149-47302 Sentence denotes 2018). (a-f) Modified and reprinted with permission from El-Hage et al. (2006a). (g-k) Modified and reprinted with permission from El-Hage et al. (2008a)
T698 47304-47353 Sentence denotes Opioid and HIV Interactive Pathology in Microglia
T699 47354-47465 Sentence denotes Unlike in astrocytes, opiate and HIV interactions in microglia tend to be self-limiting (Turchan-Cholewo et al.
T700 47466-47472 Sentence denotes 2009).
T701 47473-47657 Sentence denotes Opiates initially trigger large increases in the production of proinflammatory cytokines (Hauser, unpublished), reactive oxygen (ROS) and nitrogen (RNS) species (Turchan-Cholewo et al.
T702 47658-47707 Sentence denotes 2009), and the release of glutamate (Gupta et al.
T703 47708-47789 Sentence denotes 2010) and ATP (Sorrell and Hauser 2014) extracellularly in Tat-exposed microglia.
T704 47790-47911 Sentence denotes The release of glutamate is mediated by the catalytic subunit of the cystine-glutamate antiporter xc− (xCT) (Gupta et al.
T705 47912-47918 Sentence denotes 2010).
T706 47919-48158 Sentence denotes Interestingly, following acute increases in the release of cytokines (e.g., TNF-α; unpublished), morphine no longer increases Tat-induced cytokine levels at 24 h; instead, their levels are reduced by opiate-dependent proteasome inhibition.
T707 48159-48388 Sentence denotes The proteasome inhibitor, MG115, mimics the effects of morphine in decreasing proteasome activity at 24 h and blocks TNFα, IL-6, and CCL2 release from microglia, but does not increase ROS or RNS production (Turchan-Cholewo et al.
T708 48389-48395 Sentence denotes 2009).
T709 48396-48562 Sentence denotes The ubiquitin proteasome system (UPS) is typically viewed as contributing to opiate tolerance and physical dependence by modulating MOR downregulation (Massaly et al.
T710 48563-48582 Sentence denotes 2014; Caputi et al.
T711 48583-48636 Sentence denotes 2019), rather than MOR activity constraining the UPS.
T712 48637-48984 Sentence denotes Thus, while HIV-exposed, MOR-expressing microglia show a burst of ROS and proinflammatory cytokine production in response to morphine, the cytokine release collapses within 24 h seemingly because sustained opiate exposure inhibits the UPS thereby preventing degradation of the IκB subunit and nuclear translocation of NF-κB (Turchan-Cholewo et al.
T713 48985-48991 Sentence denotes 2009).
T714 48992-49197 Sentence denotes While neither astroglia nor microglia alone mimic the full inflammatory profile seen with opiates and HIV in the CNS; in combination, the neuroimmune signature more accurately mimics that seen in neuroHIV.
T715 49198-49398 Sentence denotes Accordingly, we have proposed that opioids promote positive feedback through separate actions in astroglia and microglia in neuroHIV—resulting in spiraling inflammation and cytotoxicity (Hauser et al.
T716 49399-49411 Sentence denotes 2005, 2007).
T717 49413-49460 Sentence denotes Opioid and HIV Interactive Pathology in Neurons
T718 49461-49765 Sentence denotes Besides accentuating HIV-induced neurotoxicity via glial-mediated mechanisms, morphine appears to converge with HIV Tat to dysregulate ion homeostasis and dendritic injury through potential direct actions on neurons, even though some contributions of glia cannot be excluded in this study (Fitting et al.
T719 49766-49773 Sentence denotes 2014a).
T720 49774-50095 Sentence denotes Combined morphine and Tat exposure accelerates the formation of Tat-induced focal dendritic varicosities/swelling via a MOR-related mechanism that was caused by focal increases in Na+ influx and [Ca2+]i, an overload of Na+/K+-ATPase, ATP depletion, and a collapse in mitochondrial inner membrane potential (Fitting et al.
T721 50096-50103 Sentence denotes 2014a).
T722 50104-50322 Sentence denotes Importantly, morphine’s additive effects were mediated via a MOR-related mechanism, as the exacerbating effects of morphine were absent in neurons from MOR knockout mice, thus excluding TLR4 involvement (Fitting et al.
T723 50323-50330 Sentence denotes 2014a).
T724 50331-50487 Sentence denotes Further, morphine exacerbated Tat-dependent focal losses in ion homeostasis by mobilizing [Ca2+]i through ryanodine-2 (RyR2)-sensitive sites (Fitting et al.
T725 50488-50504 Sentence denotes 2014a) (Fig. 2).
T726 50505-50612 Sentence denotes Although morphine typically acts via MOR in an inhibitory manner by activating Gi/o-proteins (Sharma et al.
T727 50613-50632 Sentence denotes 1977; Moises et al.
T728 50633-50746 Sentence denotes 1994; Al-Hasani and Bruchas 2011), MOR-dependent stimulation of PI3-kinase and Ca2+ mobilization (Leopoldt et al.
T729 50747-50807 Sentence denotes 1998) in neurons via the Gβγ protein subunit (Mathews et al.
T730 50808-50850 Sentence denotes 2008) is presumed operative here (Fig. 2).
T731 50851-51148 Sentence denotes Fig. 2 Morphine exacerbates the excitotoxic effects of HIV Tat by mobilizing Ca2+ from ryanodine (RyR)-sensitive internal stores. (a) Tat-induced increases in [Ca2+]i were not attenuated by ryanodine, whereas ryanodine and pyruvate attenuate combined Tat and morphine-induced increases in [Ca2+]i.
T732 51149-51501 Sentence denotes Nimodipine (L-type Ca2+ channel blocker) and dantrolene did not show any effects. (b) Average [Ca2+]i over 10 min indicated ryanodine significantly blocked combined Tat and morphine-induced increases in [Ca2+]i, whereas no effects were noted for nimodipine, dantrolene, or pyruvate. *p < 0.05 vs. control, #p < 0.05 vs. Tat 50 nM, §p < 0.05 vs. TM, TM:
T733 51502-51630 Sentence denotes Tat 50 nM + Morphine 500 nM. (c) Summary of HIV-1 Tat and morphine interactive neuronal injury in striatal medium spiny neurons.
T734 51631-52076 Sentence denotes Combined Tat and morphine promotes structural and functional defects in dendrites via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR), N-methyl-D-aspartic acid receptors (NMDAR), and MOR, causing influxes of Na+ and/or Ca2+, compensatory increases in Na+/K+-dependent ATPase activity, and a rapid loss in ATP mobilization with an inability to extrude excess Na+ via Na+/K+-ATPase caused by mitochondrial hyperpolarization.
T735 52077-52508 Sentence denotes Dysregulation of [Ca2+]i homeostasis by combined Tat and morphine appears to be mediated downstream of [Na+]i at the level of calcium mobilization, which in turn appears to be regulated via ryanodine (RyR)-sensitive sites, and enhanced by morphine exposure likely via MOR-dependent stimulation of PI3-kinase and Ca2+ mobilization via the Gβγ protein subunit. (a-b) Modified and reprinted with permission from Fitting et al. (2014a)
T736 52509-52561 Sentence denotes Glial-derived neuronal injury is not unidirectional.
T737 52562-52760 Sentence denotes Neuronal damage-associated molecular patterns (DAMPs) and dysfunction can trigger both infected and uninfected glia to become reactive, resulting in further neuronal damage and escalating pathology.
T738 52761-52852 Sentence denotes Neuronal injury can reactivate HIV in latently infected microglia (Alvarez-Carbonell et al.
T739 52853-52859 Sentence denotes 2019).
T740 52860-53318 Sentence denotes While the events underlying the disruption of neuronal-microglial activation that trigger the emergence of latent HIV are unclear, the induction of HIV expression appears to involve the production of DAMPs by injured neurons and can be turned “on”, e.g., by methamphetamine-induced sigma-1 (σ1) receptor activation, TNF-α and IL-1β, and TLR3 activation can be turned “off” by CX3CL1/fractalkine or glucocorticoid receptor activation (Alvarez-Carbonell et al.
T741 53319-53331 Sentence denotes 2017, 2019).
T742 53333-53400 Sentence denotes Neural Systems Selectively Disrupted by Opiate and HIV Interactions
T743 53402-53448 Sentence denotes Blood-Brain Barrier and the Neurovascular Unit
T744 53449-53624 Sentence denotes Despite growing evidence on how opiates and HIV interact to impact the neuropathology of HIV, little is known about their interactive effects on the blood-brain barrier (BBB).
T745 53625-53787 Sentence denotes BBB integrity and function are critical for maintaining CNS homeostasis, and mediating neuroimmune interactions with the periphery and drug delivery into the CNS.
T746 53788-53898 Sentence denotes HIV and many individual HIV proteins can breakdown the BBB disrupting tight junction proteins (Dallasta et al.
T747 53899-53917 Sentence denotes 1999; Boven et al.
T748 53918-53937 Sentence denotes 2000; Andras et al.
T749 53938-53958 Sentence denotes 2003; Mahajan et al.
T750 53959-53980 Sentence denotes 2008; Banerjee et al.
T751 53981-54000 Sentence denotes 2010; Gandhi et al.
T752 54001-54016 Sentence denotes 2010; Xu et al.
T753 54017-54035 Sentence denotes 2012; Patel et al.
T754 54036-54161 Sentence denotes 2017) and decreasing transendothelial electrical resistance (TEER) (an in vitro measure of barrier integrity) (Mahajan et al.
T755 54162-54181 Sentence denotes 2008; Gandhi et al.
T756 54182-54223 Sentence denotes 2010; Mishra and Singh 2014; Patel et al.
T757 54224-54351 Sentence denotes 2017), with resultant paracellular “leakage” of compounds/current between compromised barrier endothelial cells (Mahajan et al.
T758 54352-54371 Sentence denotes 2008; Gandhi et al.
T759 54372-54388 Sentence denotes 2010; Wen et al.
T760 54389-54408 Sentence denotes 2011; McLane et al.
T761 54409-54430 Sentence denotes 2014; Leibrand et al.
T762 54431-54443 Sentence denotes 2017, 2019).
T763 54444-54579 Sentence denotes Although opioids can also impair the BBB through alterations in tight junction proteins and/or increased paracellular flux (Baba et al.
T764 54580-54600 Sentence denotes 1988; Mahajan et al.
T765 54601-54617 Sentence denotes 2008; Wen et al.
T766 54618-54639 Sentence denotes 2011; Leibrand et al.
T767 54640-54800 Sentence denotes 2019), others have found that it is morphine withdrawal, not the continued exposure to morphine, that most greatly disrupts BBB integrity (Sharma and Ali 2006).
T768 54801-54960 Sentence denotes In addition to perturbing paracellular dynamics, morphine may also alter the expression and/or function of drug efflux proteins, such as P-glycoprotein (P-gp).
T769 54961-55076 Sentence denotes Sub-chronic and chronic morphine exposure is reported to increase P-gp expression and/or function (Aquilante et al.
T770 55077-55097 Sentence denotes 2000; Mahajan et al.
T771 55098-55117 Sentence denotes 2008; Yousif et al.
T772 55118-55139 Sentence denotes 2008; Leibrand et al.
T773 55140-55146 Sentence denotes 2019).
T774 55147-55244 Sentence denotes Alternatively, other investigators report no changes in P-gp with chronic exposure (Chaves et al.
T775 55245-55316 Sentence denotes 2016), while some see increases upon morphine withdrawal (Yousif et al.
T776 55317-55336 Sentence denotes 2012; Chaves et al.
T777 55337-55343 Sentence denotes 2016).
T778 55344-55481 Sentence denotes Alterations in drug transport proteins would impact the central accumulation and efficacy of therapeutic drugs that are their substrates.
T779 55482-55824 Sentence denotes Using a primary human brain microvascular endothelial cell (BMEC) and astrocyte co-culture model, Mahajan et al. (2008) were among the first to demonstrate that co-exposure to morphine and HIV-1 Tat resulted in greater increases in TNF-α and IL-8 levels and decreases in barrier tightness (measured by TEER) than either morphine or Tat alone.
T780 55825-56065 Sentence denotes Morphine and Tat co-exposure also additively increased JAM-2, while zonula occludens-1 (ZO-1) levels were decreased by morphine or by Tat individually, and occludin protein levels were decreased by morphine alone but not Tat (Mahajan et al.
T781 56066-56072 Sentence denotes 2008).
T782 56073-56234 Sentence denotes Using the inducible Tat transgenic mouse model, Leibrand et al. (2019), also demonstrated that HIV-1 Tat and morphine act independently to disrupt BBB integrity.
T783 56235-56408 Sentence denotes In these studies, morphine, and to a lesser extent Tat, exposure increased the leakage of fluorescently labeled dextrans from the circulation into the brain (Leibrand et al.
T784 56409-56430 Sentence denotes 2017, 2019) (Fig. 3).
T785 56431-56548 Sentence denotes Morphine exposure decreased the penetration of select ARVs in the brain, in a region-specific manner (Leibrand et al.
T786 56549-56564 Sentence denotes 2019) (Fig. 3).
T787 56565-56768 Sentence denotes Morphine exposure also resulted in increased expression and function of the drug efflux transport protein, P-gp, suggesting a mechanism by which morphine decreased the ARV concentrations (Leibrand et al.
T788 56769-56775 Sentence denotes 2019).
T789 56776-56922 Sentence denotes This finding suggests that morphine exposure could impact the efficient delivery of any therapeutic drug that is a substrate of P-gp into the CNS.
T790 56923-57054 Sentence denotes Future research should also investigate morphine’s impact on other drug transport proteins important for ARV delivery to the brain.
T791 57055-57156 Sentence denotes Fig. 3 Effects of HIV-1 Tat and morphine on BBB leakiness and on antiretroviral brain concentrations.
T792 57157-57447 Sentence denotes After 14 days of Tat induction, there was a significant increase in the 10 kDa (Cascade Blue®) tracer leakage into the brain in Tat + placebo as compared to Tat − placebo mice (*p < 0.05) and in Tat − mouse brains upon exposure to morphine as compared to Tat − placebo mice (*p < 0.05) (a).
T793 57448-57796 Sentence denotes There was a significant main effect of morphine, resulting in reduced integrity of the BBB and increased leakage of the higher molecular weight (40 kDa and 70 kDa) tracers in morphine-exposed groups as compared to the those groups (Tat + and Tat − together) not exposed to morphine (placebo) (#p < 0.05; significant main effect of morphine) (b, c).
T794 57797-57956 Sentence denotes Data represent the fold change in mean fluorescence intensity ± SEM; n = 8 Tat−/placebo, n = 6 Tat+/placebo, n = 9 Tat−/morphine, and n = 7 Tat+/morphine mice.
T795 57957-58132 Sentence denotes Additionally, morphine exposure increased horseradish peroxidase (HRP) extravasation from the vasculature into the perivascular space and/or parenchyma in the striatum (d, e).
T796 58133-58370 Sentence denotes HRP antigenicity was detected by indirect immunofluorescence (red) in tissue sections counterstained with Hoechst 33342 (blue) to reveal cell nuclei and visualized by differential interference contrast (DIC)-enhanced confocal microscopy.
T797 58371-58532 Sentence denotes HRP extravasation into the striatal perivascular space/parenchyma was especially prevalent in morphine-exposed mice (arrowheads; left-hand panels in e versus d).
T798 58533-58803 Sentence denotes The dotted lines (············) indicate the approximate edge of the capillaries/post-capillary venules; while intermittent dotted lines (· · · · · · ·) indicate the approximate edge of a partly sectioned blood vessel that appears partially outside the plane of section.
T799 58804-58871 Sentence denotes The asterisks (*) indicate white matter tracts within the striatum.
T800 58872-58923 Sentence denotes Representative samples from ≥ n = 4 mice per group.
T801 58924-58962 Sentence denotes All images are the same magnification.
T802 58963-58981 Sentence denotes Scale bar = 10 μm.
T803 58982-59039 Sentence denotes Antiretroviral tissue-to-plasma ratios in striatum (f–g).
T804 59040-59258 Sentence denotes Irrespective of Tat exposure, morphine significantly reduced the levels of dolutegravir (f) and abacavir (g), but not lamivudine (h), within the striatum, as compared to placebo. (* p < 0.05; main effect for morphine).
T805 59259-59484 Sentence denotes Data represent the tissue-to-plasma ratios ± SEM sampled from n = 9 Tat−/placebo, n = 9 Tat+/placebo, n = 6 Tat−/morphine, and n = 8 Tat+/morphine mice. (a–h) Modified and reprinted with permission from Leibrand et al. (2019)
T806 59485-59647 Sentence denotes HIV, HIV-1 viral proteins, and opiate-induced barrier dysfunction is associated with increased infiltration of monocyte-derived macrophages (MDMs) into the brain.
T807 59648-59794 Sentence denotes Enhanced influx of peripheral (infected) macrophages into the brain can serve to replenish viral reservoirs and further promote neuroinflammation.
T808 59795-59933 Sentence denotes Several studies have examined the individual impact of HIV, Tat, or morphine on monocyte adhesion or migration into the CNS (Nottet et al.
T809 59934-59949 Sentence denotes 1996; Wu et al.
T810 59950-59976 Sentence denotes 2000; Fischer-Smith et al.
T811 59977-59995 Sentence denotes 2001; Pello et al.
T812 59996-60017 Sentence denotes 2006; Williams et al.
T813 60018-60045 Sentence denotes 2013a, 2014; Strazza et al.
T814 60046-60067 Sentence denotes 2016; Leibrand et al.
T815 60068-60089 Sentence denotes 2017; Chilunda et al.
T816 60090-60096 Sentence denotes 2019).
T817 60097-60178 Sentence denotes However, fewer studies have examined the combined effects of HIV/Tat and opiates.
T818 60179-60337 Sentence denotes Co-exposure of HIV-1 Tat and morphine on astrocytes increases the production of chemoattractants, primarily CCL2 and CCL5, and increases microglial migration.
T819 60338-60398 Sentence denotes These effects were inhibited by MOR blockade (El-Hage et al.
T820 60399-60406 Sentence denotes 2006b).
T821 60407-60561 Sentence denotes Co-exposure of Tat and morphine or buprenorphine to a BBB model increases monocyte transmigration in response to CCL5 and other chemokines (Mahajan et al.
T822 60562-60595 Sentence denotes 2008; Jaureguiberry-Bravo et. al.
T823 60596-60602 Sentence denotes 2016).
T824 60603-60776 Sentence denotes In S. pneumoniae-infected mice, morphine and/or Tat exposure significantly enhances immune cell trafficking into the brain via actions at TLR2 and TLR4 (Dutta and Roy 2015).
T825 60777-60873 Sentence denotes Taken together, BBB damage from HIV and/or opiates can disrupt the homeostasis within the brain.
T826 60874-61201 Sentence denotes Breakdown of paracellular processes, through decreases in tight junction proteins and increased cellular adhesion proteins, increased leakage of circulating molecules into the brain and increased monocyte/MDM adhesion and transmigration into the brain, which if infected, can serve to replenish viral reservoirs within the CNS.
T827 61202-61331 Sentence denotes Furthermore, alterations in drug transport proteins within the brain can decrease ARV efficacy by decreasing drug concentrations.
T828 61332-61438 Sentence denotes Collectively, these changes serve to maintain HIV infection within the brain (see Fig. 4; Tables 1 and 2).
T829 61439-61545 Sentence denotes Fig. 4 Schematic representation of the blood-brain barrier and other components of the neurovascular unit.
T830 61546-61757 Sentence denotes Under normal conditions (represented above the dotted line), tight junctions are intact which restricts the leakage of paracellular, typically small hydrophilic, compounds, across the barrier and into the brain.
T831 61758-61957 Sentence denotes Additionally, there is a basal expression of efflux transporters, such as P-glycoprotein (P-gp), which effluxes substrates out of the brain, serving to restrict overall accumulation within the brain.
T832 61958-62152 Sentence denotes In the setting of HIV and opiate exposure (represented below the dotted line), there is a breakdown of the tight junction proteins and increased leakage of paracellular compounds into the brain.
T833 62153-62474 Sentence denotes Additionally, opiate exposure increases efflux transporter expression, including P-gp and potentially breast cancer resistance protein (Bcrp), thereby restricting overall brain penetration of drugs (like many antiretroviral drugs) which are substrates for these transporters and in response to HIV and/or opioid exposure.
T834 62476-62515 Sentence denotes White Matter/Oligodendroglial Pathology
T835 62516-62567 Sentence denotes HIV can cause white matter damage (Gosztonyi et al.
T836 62568-62589 Sentence denotes 1994; Langford et al.
T837 62590-62607 Sentence denotes 2002; Xuan et al.
T838 62608-62662 Sentence denotes 2013) even with less severe forms of HAND (Chen et al.
T839 62663-62681 Sentence denotes 2009; Leite et al.
T840 62682-62701 Sentence denotes 2013; Correa et al.
T841 62702-62708 Sentence denotes 2015).
T842 62709-62819 Sentence denotes Diffusion tensor magnetic resonance imaging (DTI) demonstrates white matter damage early in HAND (Ragin et al.
T843 62820-62845 Sentence denotes 2004; Stubbe-Drger et al.
T844 62846-62864 Sentence denotes 2012; Leite et al.
T845 62865-62884 Sentence denotes 2013; Correa et al.
T846 62885-62891 Sentence denotes 2015).
T847 62892-63000 Sentence denotes White matter deficits are associated with cognitive impairment, including shortfalls in memory (Ragin et al.
T848 63001-63041 Sentence denotes 2005), executive function (Correa et al.
T849 63042-63071 Sentence denotes 2015), motor speed (Wu et al.
T850 63072-63097 Sentence denotes 2006; Stubbe-Drger et al.
T851 63098-63158 Sentence denotes 2012), and perhaps depression (Schmaal and van Velzen 2019).
T852 63159-63261 Sentence denotes Preclinical studies in simian immunodeficiency virus- (SIV-) infected rhesus macaques (Marcario et al.
T853 63262-63313 Sentence denotes 2008) and HIV-infected humanized mice (Boska et al.
T854 63314-63350 Sentence denotes 2014) support the clinical findings.
T855 63351-63443 Sentence denotes Injury to oligodendrocytes (OLs) can occur very early in the disease (see review, Liu et al.
T856 63444-63451 Sentence denotes 2016b).
T857 63452-63563 Sentence denotes Viral proteins, including Tat, gp120, and Nef, have been implicated in OL injury in vitro (Kimura-Kuroda et al.
T858 63564-63585 Sentence denotes 1994; Bernardo et al.
T859 63586-63604 Sentence denotes 1997; Radja et al.
T860 63605-63626 Sentence denotes 2003; Nukuzuma et al.
T861 63627-63643 Sentence denotes 2012; Zou et al.
T862 63644-63693 Sentence denotes 2015), and in animal models in vivo (Radja et al.
T863 63694-63713 Sentence denotes 2003; Hauser et al.
T864 63714-63730 Sentence denotes 2009; Zou et al.
T865 63731-63737 Sentence denotes 2015).
T866 63738-63828 Sentence denotes Importantly, Tat has been detected in OLs in the brains of AIDS patients (Del Valle et al.
T867 63829-63835 Sentence denotes 2000).
T868 63836-63900 Sentence denotes HIV likely damages OLs through both direct and indirect actions.
T869 63901-63976 Sentence denotes OLs lack CD4, and reports of OL infection by HIV are variable (Esiri et al.
T870 63977-63998 Sentence denotes 1991; Albright et al.
T871 63999-64025 Sentence denotes 1996; Wohlschlaeger et al.
T872 64026-64134 Sentence denotes 2009); thus, HIV infection of OLs is unlikely a major avenue of OL or white matter damage (discussed below).
T873 64135-64322 Sentence denotes Alternatively, bystander damage to OLs through the production of “virotoxins” and “cellular toxins” (Nath 1999) by infected neighboring cells is more likely to be operative (Hauser et al.
T874 64323-64339 Sentence denotes 2009; Zou et al.
T875 64340-64359 Sentence denotes 2015; Jensen et al.
T876 64360-64376 Sentence denotes 2019; Zou et al.
T877 64377-64383 Sentence denotes 2019).
T878 64384-64438 Sentence denotes ARVs also contribute to OL cytotoxicity (Jensen et al.
T879 64439-64457 Sentence denotes 2015; Festa et al.
T880 64458-64477 Sentence denotes 2019; Jensen et al.
T881 64478-64484 Sentence denotes 2019).
T882 64485-64676 Sentence denotes HIV-1 Tat directly induces damage in isolated OLs through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/N-methyl-D-aspartic acid (NMDA) receptor-dependent mechanisms (Zou et al.
T883 64677-64746 Sentence denotes 2015) and is also associated with abnormal Kv1.3 activity (Liu et al.
T884 64747-64753 Sentence denotes 2017).
T885 64754-64850 Sentence denotes Immature OLs are preferentially targeted by Tat compared to differentiated OLs (Khurdayan et al.
T886 64851-64868 Sentence denotes 2004; Hahn et al.
T887 64869-64885 Sentence denotes 2012; Zou et al.
T888 64886-64898 Sentence denotes 2015, 2019).
T889 64899-65147 Sentence denotes While the reasons why immature OLs are more susceptible to Tat are unclear, unlike mature OLs, Tat preferentially upregulates GSK-3β signaling in undifferentiated OLs by inhibiting Ca2+/calmodulin-dependent protein kinase II β (CaMKIIβ) (Zou et al.
T890 65148-65154 Sentence denotes 2019).
T891 65155-65319 Sentence denotes Opioid abuse by itself can result in demyelination, leukoencephalopathy, and lesions in white matter (Offiah and Hall 2008; Eran and Barak 2009; Morales Odia et al.
T892 65320-65337 Sentence denotes 2010; Bora et al.
T893 65338-65353 Sentence denotes 2012; Li et al.
T894 65354-65460 Sentence denotes 2013), and the degree of myelin disruption correlates with the duration of opiate dependence (Ivers et al.
T895 65461-65467 Sentence denotes 2018).
T896 65468-65685 Sentence denotes Chronic oxycodone exposure in rats causes some axonopathies and reduces the size of axonal fascicles, decreases myelin basic protein levels, and causes the accumulation of amyloid-β precursor protein (APP) (Fan et al.
T897 65686-65692 Sentence denotes 2018).
T898 65693-65848 Sentence denotes Most preclinical studies have examined the effects of opioids and opioid receptor blockade on OL maturation and/or the timing of myelination (Hauser et al.
T899 65849-65867 Sentence denotes 1993; Knapp et al.
T900 65868-65894 Sentence denotes 1998; Stiene-Martin et al.
T901 65895-65915 Sentence denotes 2001; Sanchez et al.
T902 65916-65934 Sentence denotes 2008; Knapp et al.
T903 65935-65962 Sentence denotes 2009; Vestal-Laborde et al.
T904 65963-65969 Sentence denotes 2014).
T905 65970-66048 Sentence denotes OLs can transiently express MORs and other opioid receptor types (Knapp et al.
T906 66049-66073 Sentence denotes 1998; Tryoen-Toth et al.
T907 66074-66092 Sentence denotes 2000; Knapp et al.
T908 66093-66119 Sentence denotes 2001; Stiene-Martin et al.
T909 66120-66126 Sentence denotes 2001).
T910 66127-66254 Sentence denotes Selective MOR and possibly KOR activation can directly modulate the growth of OLs in vitro (Knapp and Hauser 1996; Knapp et al.
T911 66255-66267 Sentence denotes 1998, 2001).
T912 66268-66387 Sentence denotes Despite long-standing evidence of white matter damage early during the infection even in asymptomatic PWH (Price et al.
T913 66388-66405 Sentence denotes 1988; Gray et al.
T914 66406-66423 Sentence denotes 1996; Chen et al.
T915 66424-66449 Sentence denotes 2009; Stubbe-Drger et al.
T916 66450-66469 Sentence denotes 2012; Jensen et al.
T917 66470-66575 Sentence denotes 2019), few studies have examined how opiate exposure affects OLs and myelin in neuroHIV (Tables 1 and 2).
T918 66576-66721 Sentence denotes Increased demyelination is reported in SIV-infected rhesus macaques chronically treated with morphine (4× daily, up to 59 weeks) (Marcario et al.
T919 66722-66728 Sentence denotes 2008).
T920 66729-66901 Sentence denotes Specifically, morphine-treated SIV macaques developed more subtle, focal, dysmyelinating lesions, with accumulations of macrophages in areas of myelin loss (Marcario et al.
T921 66902-66957 Sentence denotes 2008), as well as accompanying gliosis (Marcario et al.
T922 66958-66983 Sentence denotes 2008; Rivera-Amill et al.
T923 66984-67005 Sentence denotes 2010a; Bokhari et al.
T924 67006-67012 Sentence denotes 2011).
T925 67013-67232 Sentence denotes Morphine exposure increased degeneration of OLs in Tat+ mice, which was accompanied by elevations in caspase-3 activation and TUNEL reactivity in OLs and reversible by naloxone or naltrexone, respectively (Hauser et al.
T926 67233-67239 Sentence denotes 2009).
T927 67240-67303 Sentence denotes Although OLs can express MOR both in vivo (Stiene-Martin et al.
T928 67304-67337 Sentence denotes 2001) and in vitro (Hauser et al.
T929 67338-67441 Sentence denotes 2009), it remains unclear the extent to which MOR activation in OLs directly mediates HIV pathogenesis.
T930 67443-67504 Sentence denotes Neural Progenitors as an HIV Reservoir and Target for Opioids
T931 67505-67579 Sentence denotes Even though neural progenitors (Krathwohl and Kaiser 2004; Lawrence et al.
T932 67580-67605 Sentence denotes 2004; Rothenaigner et al.
T933 67606-67627 Sentence denotes 2007; Schwartz et al.
T934 67628-67649 Sentence denotes 2007; Balinang et al.
T935 67650-67693 Sentence denotes 2017), neuroblast cell lines (Ensoli et al.
T936 67694-67719 Sentence denotes 1994; Rothenaigner et al.
T937 67720-67767 Sentence denotes 2007), and/or immature astroglia (Atwood et al.
T938 67768-67790 Sentence denotes 1993; Tornatore et al.
T939 67791-67809 Sentence denotes 1994; Barat et al.
T940 67810-67893 Sentence denotes 2018) can harbor HIV infection (reviewed by Hauser and Knapp 2014; Putatunda et al.
T941 67894-68012 Sentence denotes 2019), the degree to which they are a source of active infection or serve as a latent viral reservoir (Blankson et al.
T942 68013-68032 Sentence denotes 2002; Bruner et al.
T943 68033-68121 Sentence denotes 2019) by retaining intact proviral DNA within incipient macroglial progeny is uncertain.
T944 68122-68198 Sentence denotes In fact, spurious reports of HIV-infected adult neurons (Torres-Munoz et al.
T945 68199-68224 Sentence denotes 2001; Canto-Nogues et al.
T946 68225-68382 Sentence denotes 2005) may result from the retention of proviral genes that integrated into pluripotent neural progenitors or neuroblasts at earlier stages during maturation.
T947 68383-68502 Sentence denotes Importantly, prolonged exposure to opioids can increase the production of HIV in human neural progenitor cells (hNPCs).
T948 68503-68668 Sentence denotes Exposure of R5-tropic HIVBaL-infected hNPCs to morphine continuously for 21 d increased viral production compared to HIVBaL infection alone in vitro (Balinang et al.
T949 68669-68675 Sentence denotes 2017).
T950 68676-68783 Sentence denotes Besides being able to infect hNPCs, HIV may also affect their maturation and the fate of neural stem cells.
T951 68784-68848 Sentence denotes That HIV or gp120 can inhibit adult neurogenesis (Okamoto et al.
T952 68849-68865 Sentence denotes 2007; Lee et al.
T953 68866-68888 Sentence denotes 2013; Putatunda et al.
T954 68889-68973 Sentence denotes 2018) has been the topic of past reviews (Schwartz and Major 2006; Venkatesan et al.
T955 68974-68991 Sentence denotes 2007; Peng et al.
T956 68992-69068 Sentence denotes 2008, 2011; Ferrell and Giunta 2014; Hauser and Knapp 2014; Putatunda et al.
T957 69069-69075 Sentence denotes 2019).
T958 69076-69283 Sentence denotes How HIV inhibits the self-renewal, tripotential differentiation, and survival of neural progenitors/stem cells or the genesis of adult neurons in the subgranular zone (SGZ) of the dentate gyrus is uncertain.
T959 69284-69461 Sentence denotes HIV and gp120 [via actions at the same chemokine receptor(s) (Tran and Miller 2005; Li and Ransohoff 2008)] are proposed to modulate the adult neurogenesis via Notch (Fan et al.
T960 69462-69587 Sentence denotes 2016), by obstructing a cell cycle checkpoint via the activation MAPK-activated protein kinase 2 and Cdc25B/C (Okamoto et al.
T961 69588-69665 Sentence denotes 2007), or through signaling by platelet-derived growth factor BB (Chao et al.
T962 69666-69691 Sentence denotes 2014) or BDNF (Lee et al.
T963 69692-69698 Sentence denotes 2013).
T964 69699-69988 Sentence denotes The extent that HIV regulates the genesis of neural progenitors within the subventricular zone of the developing CNS through similar mechanisms as in the adult SGZ of the dentate gyrus is uncertain—even though HIV disrupts the generation of neurons and glia during maturation or in adults.
T965 69989-70158 Sentence denotes For example, MAPK/ERK1/2 enhances p53- and p21-dependent downregulation of cyclin D1 hindering progression through the G1 phase of the cell cycle in hNPCs (Mishra et al.
T966 70159-70177 Sentence denotes 2010; Malik et al.
T967 70178-70184 Sentence denotes 2014).
T968 70185-70357 Sentence denotes Importantly, opioids too can affect the genesis of neurons and glia during maturation or in the adult directly via convergent pathways (Hauser and Knapp 2018; Kibaly et al.
T969 70358-70486 Sentence denotes 2018) suggesting yet another site of opioid and HIV interactions in dysregulating the creation and fate of new neurons and glia.
T970 70487-70584 Sentence denotes Few studies have examined the interplay between opioids, neural progenitors and HIV/HIV proteins.
T971 70585-70818 Sentence denotes Sustained exposure (4 d) to morphine (500 nM) and Tat1–72 (100 nM) decreased the viability of MOR-expressing striatal glial precursors, and to a lesser extent astrocytes, and this coincided with caspase-3 activation (Khurdayan et al.
T972 70819-70825 Sentence denotes 2004).
T973 70826-71040 Sentence denotes By contrast, comparably administered morphine or Tat alone was sufficient to decrease the viability of immature glia/glial progenitors in spinal cord cultures, while Tat and morphine failed to interact (Buch et al.
T974 71041-71047 Sentence denotes 2007).
T975 71048-71277 Sentence denotes Collectively, these findings were the first to indicate that opioid and/or Tat could enhance programmed cell death in subpopulations of glial precursors in a developmentally regulated and region-dependent manner (Khurdayan et al.
T976 71278-71295 Sentence denotes 2004; Buch et al.
T977 71296-71302 Sentence denotes 2007).
T978 71303-71596 Sentence denotes In human glial progenitors, co-administering morphine (500 nM) increased the antiproliferative effects of Tat (12–48 h) or conditioned medium from HIV-1SF162-infected MDMs (12 h), while paradoxically reversing the antiproliferative effects from HIV-1IIIB conditioned medium (12 h) (Hahn et al.
T979 71597-71603 Sentence denotes 2012).
T980 71604-71812 Sentence denotes In these studies, Tat or HIV exposure reduced the proliferation of Sox2+ and Olig2+ undifferentiated glial and oligodendroglial progenitors, respectively, while progenitor viability was unchanged (Hahn et al.
T981 71813-71819 Sentence denotes 2012).
T982 71820-72091 Sentence denotes In human neural progenitor cells (hNPCs), sustained infection with R5-tropic HIVBaL increased the proliferation and premature differentiation of hNPCs into both neurons and astrocytes, and both measures were significantly enhanced by morphine co-exposure (Balinang et al.
T983 72092-72098 Sentence denotes 2017).
T984 72099-72154 Sentence denotes Importantly, immunoneutralizing antibodies (Hahn et al.
T985 72155-72216 Sentence denotes 2012) or the selective antagonist, maraviroc (Balinang et al.
T986 72217-72390 Sentence denotes 2017), were able to significantly attenuate the consequences of R5-tropic HIV infection on hNPC differentiation and fate confirming a direct role of CCR5 in these processes.
T987 72391-72559 Sentence denotes Lastly, decreases in the proliferation of hNPCs seen with morphine and Tat are, in part, regulated by ERK1/2-dependent increases in p53 and p21 expression (Malik et al.
T988 72560-72652 Sentence denotes 2014) and can be modulated by PDGF BB suggesting a possible therapeutic target (Malik et al.
T989 72653-72659 Sentence denotes 2011).
T990 72660-72854 Sentence denotes Thus, morphine can exaggerate R5-tropic HIV-induced alterations in the maturation and fate of human and rodent NPCs, thereby further disrupting the balance of neural cell types and CNS function.
T991 72856-72923 Sentence denotes Matters Needing Further Consideration in Opioid and HIV Comorbidity
T992 72924-73056 Sentence denotes The interplay of complex host and viral genetic differences is likely to play a huge role in determining pathologic outcomes in PWH.
T993 73057-73117 Sentence denotes For example, differences in HIV strains/variants (Rao et al.
T994 73118-73177 Sentence denotes 2013) and human/host genetic variability (Proudnikov et al.
T995 73178-73217 Sentence denotes 2012), pharmacokinetics (Kuhlman et al.
T996 73218-73234 Sentence denotes 1996; Eap et al.
T997 73235-73296 Sentence denotes 2002; Elkader and Sproule 2005; Kharasch 2017; Kringen et al.
T998 73297-73327 Sentence denotes 2017), and sex (Zubieta et al.
T999 73328-73371 Sentence denotes 2002; Taylor and Davies 2010; Venuto et al.
T1000 73372-73392 Sentence denotes 2014; Marinho et al.
T1001 73393-73447 Sentence denotes 2019) all contribute to variability in responsiveness.
T1002 73448-73537 Sentence denotes The following subsections will focus on key factors affecting opioid and HIV comorbidity.
T1003 73539-73553 Sentence denotes HIV-1 Genetics
T1004 73554-73743 Sentence denotes Genetic differences among HIV-1 variants have a significant impact on HIV transmission, disease progression, as well as the response to ARV therapy (see reviews, Geretti 2006; Taylor et al.
T1005 73744-73761 Sentence denotes 2008; Tyor et al.
T1006 73762-73784 Sentence denotes 2013; Tables 1 and 2).
T1007 73785-73890 Sentence denotes Pre-cART studies provide substantial evidence that HIV clade differences can influence HAND (Gupta et al.
T1008 73891-73911 Sentence denotes 2007; Sacktor et al.
T1009 73912-73931 Sentence denotes 2009; Boivin et al.
T1010 73932-73953 Sentence denotes 2010; McArthur et al.
T1011 73954-73970 Sentence denotes 2010; Rao et al.
T1012 73971-74077 Sentence denotes 2013), with HAND severity being highest for clade D and B strains, followed by C and A clades (Tyor et al.
T1013 74078-74084 Sentence denotes 2013).
T1014 74085-74273 Sentence denotes These findings are supported by preclinical studies in which clade B or clade C HIV-infected macrophages were intracranially injected into severe combined immunodeficient mice (SCID) mice.
T1015 74274-74403 Sentence denotes Exposure to clade B isolates induced more severe memory deficits, as well as greater astrogliosis and neuronal damage (Rao et al.
T1016 74404-74416 Sentence denotes 2008, 2013).
T1017 74417-74573 Sentence denotes In another example, the Tat dicysteine motif (CC) at positions 30 and 31, which is commonly found in clade B isolates, appears to worsen HAND (Mishra et al.
T1018 74574-74590 Sentence denotes 2008; Rao et al.
T1019 74591-74652 Sentence denotes 2013) and has been studied extensively in vitro (Ranga et al.
T1020 74653-74669 Sentence denotes 2004; Rao et al.
T1021 74670-74686 Sentence denotes 2008; Zou et al.
T1022 74687-74723 Sentence denotes 2011; Krishnan and Chatterjee 2015).
T1023 74724-74823 Sentence denotes Clade B Tat is more intrinsically cytotoxic to primary neurons in vitro than clade C Tat (Li et al.
T1024 74824-74845 Sentence denotes 2008; Campbell et al.
T1025 74846-74862 Sentence denotes 2011; Zou et al.
T1026 74863-74966 Sentence denotes 2011), resulting in increased proinflammatory cytokine production (e.g., IL-6 and TNF-α) (Gandhi et al.
T1027 74967-75036 Sentence denotes 2009) and monocyte recruitment/migration into the brain (Ranga et al.
T1028 75037-75053 Sentence denotes 2004; Rao et al.
T1029 75054-75111 Sentence denotes 2008), and increased disruption of the BBB (Gandhi et al.
T1030 75112-75118 Sentence denotes 2010).
T1031 75119-75318 Sentence denotes Similarly, the production of the inflammatory mediators prostaglandin E2 and the thromboxane A2 receptor by astrocytes is more significantly increased by clade B than clade C gp120 (Samikkannu et al.
T1032 75319-75325 Sentence denotes 2011).
T1033 75326-75435 Sentence denotes Sequence and structural alterations in gp120 have been demonstrated between clades B and C (Gnanakaran et al.
T1034 75436-75499 Sentence denotes 2007) and potentially contribute to these observed differences.
T1035 75500-75712 Sentence denotes When considering effects of HIV clade variants in the presence of opioids, the overall toxicity in MSNs seen with clade C Tat (30% neuronal losses) was considerably less than with clade B (70% losses) (Zou et al.
T1036 75713-75719 Sentence denotes 2011).
T1037 75720-76000 Sentence denotes Although clade B HIV predominates in Western countries, future clinical longitudinal studies are necessary that employ HIV clade testing in HIV-1 infected opioid users to confirm the hypothesis that opioid interactive effects on HAND pathogenesis depend on the HIV clade assessed.
T1038 76001-76091 Sentence denotes Besides HIV genetic diversity, differences in HIV tropism add another level of complexity.
T1039 76092-76227 Sentence denotes Morphine interactions can differ significantly between X4 and R5-tropic gp120 variants depending on the outcome measure (El-Hage et al.
T1040 76228-76251 Sentence denotes 2011b; Podhaizer et al.
T1041 76252-76273 Sentence denotes 2012; Balinang et al.
T1042 76274-76290 Sentence denotes 2017; Kim et al.
T1043 76291-76297 Sentence denotes 2018).
T1044 76298-76551 Sentence denotes Increased infectivity in the presence of morphine was noted for the R5-tropic HIV-1SF162 strain in a human hepatoma Huh7.5.1 cell line model, whereas the infectivity rate with the X4-tropic HIV-1LAI/IIIB strain was unaffected by morphine (El-Hage et al.
T1045 76552-76559 Sentence denotes 2011b).
T1046 76560-76712 Sentence denotes To date, no clinical studies have assessed whether opioid interactions with R5- or R4-preferring HIV strains differentially impact the severity of HAND.
T1047 76713-76918 Sentence denotes However, the findings from preclinical studies indicate that HIV-1 strain-specific differences are critical determinants in shaping both the timing and pattern of neurotoxic interactions with opioid drugs.
T1048 76920-76933 Sentence denotes Host Genetics
T1049 76934-77110 Sentence denotes Host genetic variability can be a major determinant in individual susceptibility to HIV infectivity and may influence neuroHIV progression in the context of opiate co-exposure.
T1050 77111-77206 Sentence denotes The importance of CCR5 for HIV infectivity and polymorphisms in this gene are well established.
T1051 77207-77469 Sentence denotes Individuals who are homozygous in the CCR5 gene (CCR5Δ32) are highly resistant to infection by CCR5- (R5-) tropic HIV as demonstrated by individuals heterozygous for CCR5Δ32 who display partial resistance to infection and slower disease progression (Huang et al.
T1052 77470-77486 Sentence denotes 1996; Liu et al.
T1053 77487-77507 Sentence denotes 1996; van Rij et al.
T1054 77508-77514 Sentence denotes 1999).
T1055 77515-77673 Sentence denotes Besides CCR5, polymorphisms of other chemokine co-receptors and/or their cognate ligands have been implicated in HIV infectivity, including CCR2 (Smith et al.
T1056 77674-77696 Sentence denotes 1997; Kostrikis et al.
T1057 77697-77720 Sentence denotes 1998), CCL5 (Liu et al.
T1058 77721-77743 Sentence denotes 1999; McDermott et al.
T1059 77744-77777 Sentence denotes 2000), and CXCL12 (Winkler et al.
T1060 77778-77784 Sentence denotes 1998).
T1061 77785-77990 Sentence denotes Authoritative reviews on other gene polymorphisms that modify HIV infectivity and disease progression have been published (Lama and Planelles 2007; Singh and Spector 2009; Chatterjee 2010; Aouizerat et al.
T1062 77991-77997 Sentence denotes 2011).
T1063 77998-78215 Sentence denotes Gene polymorphisms of opioid (OPRM1 and OPRK1) and non-opioid (e.g., DRD1 and DRD2) drug/neurotransmitter receptor genes are associated with altered HIV infectivity, viral loads and CD4+ cell counts (Proudnikov et al.
T1064 78216-78234 Sentence denotes 2012; Regan et al.
T1065 78235-78254 Sentence denotes 2012; Jacobs et al.
T1066 78255-78278 Sentence denotes 2013; Proudnikov et al.
T1067 78279-78297 Sentence denotes 2013; Dever et al.
T1068 78298-78304 Sentence denotes 2014).
T1069 78305-78386 Sentence denotes Not only do MORs mediate the behavioral consequences of opiate abuse (Bond et al.
T1070 78387-78405 Sentence denotes 1998; Szeto et al.
T1071 78406-78424 Sentence denotes 2001; Ikeda et al.
T1072 78425-78443 Sentence denotes 2005; Kreek et al.
T1073 78444-78459 Sentence denotes 2005; Xu et al.
T1074 78460-78671 Sentence denotes 2014b), but the ability of MOR to modulate HIV chemokine co-receptor signaling through cross desensitization or through direct molecular interactions suggest MOR may influence HIV infectivity at multiple levels.
T1075 78672-78913 Sentence denotes The unique ability of MOR to modulate HIV co-receptor function, prompted inquiry regarding whether variants of the OPRM1 gene (polymorphisms or splicing variants) might differentially effect HIV infectivity and/or opiate addictive behaviors.
T1076 78914-79101 Sentence denotes In a sample of 1031 HIV-1-infected women, 18 OPRM1 polymorphisms were significantly associated with decreases or increases in HIV infectivity and responsiveness to cART (Proudnikov et al.
T1077 79102-79108 Sentence denotes 2012).
T1078 79109-79216 Sentence denotes Other gene polymorphisms, such as enzymes affecting drug metabolism (Meyer and Zanger 1997; Benowitz et al.
T1079 79217-79334 Sentence denotes 2006) and other neurochemical systems (Herman and Balogh 2012; Koob and Volkow 2016) can also affect drug dependence.
T1080 79335-79496 Sentence denotes The A118G variant of OPRM1 alters the regulation of proinflammatory cytokine secretion (i.e., TNF-α, IL-10, IFN-γ) from peripheral immune cells (Matsunaga et al.
T1081 79497-79503 Sentence denotes 2009).
T1082 79504-79627 Sentence denotes Overall, these findings suggest that polymorphisms in MOR ligands/genes (OPRM1) can influence the pathophysiology of HIV-1.
T1083 79628-79732 Sentence denotes Nineteen different OPRM1 spliced variants have been described in humans (Pasternak 2004, 2014; Xu et al.
T1084 79733-79749 Sentence denotes 2014a; Lu et al.
T1085 79750-79756 Sentence denotes 2015).
T1086 79757-79850 Sentence denotes OPRM1 alternative splicing may also influence susceptibility to HIV-1 infection (Dever et al.
T1087 79851-79863 Sentence denotes 2012, 2014).
T1088 79864-80140 Sentence denotes Although many variants are thought to be non-functional and fail to traffic from the endoplasmic reticulum, increasing evidence suggests they may oligomerize other G Protein-coupled receptors or bind chaperones to assist in trafficking to the plasma membrane (Samoshkin et al.
T1089 80141-80157 Sentence denotes 2015; Zhu et al.
T1090 80158-80164 Sentence denotes 2019).
T1091 80165-80339 Sentence denotes Quantitative and qualitative differences in human MOR splice variant expression levels have been noted across different CNS cell types following exposure to HIV (Dever et al.
T1092 80340-80352 Sentence denotes 2012, 2014).
T1093 80353-80439 Sentence denotes Interestingly, an excitatory, MOR-1 K splice variant, that couples to GαS (Gris et al.
T1094 80440-80506 Sentence denotes 2010) is preferentially expressed in human astroglia (Dever et al.
T1095 80507-80593 Sentence denotes 2012) and has been shown to correlate with HIVE and cognitive impairment (Dever et al.
T1096 80594-80606 Sentence denotes 2012, 2014).
T1097 80608-80661 Sentence denotes MOR and Chemokine Receptor Interactions (CCR5, CXCR4)
T1098 80662-80926 Sentence denotes The ability of opiates to modulate HIV infection and HIV neuropathogenesis/disease progression may be partly due to the interactive effects seen between the opioid and chemokine receptors, specifically MOR and CCR5 or CXCR4 (Rogers and Peterson 2003; Steele et al.
T1099 80927-80945 Sentence denotes 2003; Szabo et al.
T1100 80946-80975 Sentence denotes 2003; Festa and Meucci 2012).
T1101 80976-81108 Sentence denotes The potential mechanisms for this interaction can include heterologous cross-desensitization via downstream signaling (Rogers et al.
T1102 81109-81128 Sentence denotes 2000; Steele et al.
T1103 81129-81146 Sentence denotes 2002; Song et al.
T1104 81147-81259 Sentence denotes 2011) and/or potentially via direct opioid-chemokine receptor dimeric or heteromeric interactions (Suzuki et al.
T1105 81260-81277 Sentence denotes 2002; Chen et al.
T1106 81278-81306 Sentence denotes 2004; Nash and Meucci 2014).
T1107 81307-81431 Sentence denotes MOR and DOR activation can heterologously desensitize CCR5 responsiveness to CCL3, CCL4, and CCL5 in monocytes (Grimm et al.
T1108 81432-81450 Sentence denotes 1998; Szabo et al.
T1109 81451-81468 Sentence denotes 2003; Chen et al.
T1110 81469-81475 Sentence denotes 2004).
T1111 81476-81615 Sentence denotes The cross-desensitization appears to be regulated by MOR-dependent PKCζ activation and CCR5 phosphorylation and downregulation (Song et al.
T1112 81616-81622 Sentence denotes 2011).
T1113 81623-81795 Sentence denotes Alternatively, MOR-induced downregulation of CCL2 and CCL4 mRNA reciprocally upregulates the expression of their associated receptors, CCR2b, CCR3, and CCR5 (Mahajan et al.
T1114 81796-81802 Sentence denotes 2005).
T1115 81803-82063 Sentence denotes A previous study reported significant upregulation of CCR5 and CXCR4 expression in CD14 monocytes with [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO), a MOR ligand, exposure with enhanced replication of both X4- and R5-tropic viral strains of HIV (Steele et al.
T1116 82064-82070 Sentence denotes 2003).
T1117 82071-82350 Sentence denotes For CXCR4, bidirectional heterologous desensitization is less evident with MOR but has been reported for KOR, with Ca2+ signaling experiments suggesting that cross-desensitization occurs within seconds of KOR or CXCR4 activation in a concentration-dependent manner (Finley et al.
T1118 82351-82357 Sentence denotes 2008).
T1119 82358-82590 Sentence denotes Thus, opiates acting at different opioid receptors in the presence of HIV appear to activate chemokine receptor signaling and can contribute to the synergistic effects of HIV and opioid drug co-exposure seen in neuroHIV progression.
T1120 82591-82742 Sentence denotes The ability of opiates to modulate CCR5 expression in the CNS has been demonstrated to occur in various cell types, including microglia (Bokhari et al.
T1121 82743-82780 Sentence denotes 2009), and astrocytes (Mahajan et al.
T1122 82781-82787 Sentence denotes 2002).
T1123 82788-83011 Sentence denotes Specifically, in astrocytes MOR activation enhanced CCR5 and additional HIV-1 entry co-receptor (CCR3 and CXCR2) expression, whereas local production of HIV-1 protective chemokines (IL-8, CCL4) was inhibited (Mahajan et al.
T1124 83012-83018 Sentence denotes 2002).
T1125 83019-83161 Sentence denotes Deletion of CCR5 significantly attenuates morphine-induced increases in astrocyte CCL2 immunoreactivity in Tat transgenic mice (El-Hage et al.
T1126 83162-83178 Sentence denotes 2008a) (Fig. 1).
T1127 83179-83474 Sentence denotes Interestingly, the proportion of CCL2 immunoreactive macrophages/microglia in CCL5(−/−) mice after Tat and morphine co-administration still showed a significant upregulation, suggesting CCL5 regulates Tat and morphine-induced increases in CCL2 in astrocytes, but not in microglia (El-Hage et al.
T1128 83475-83491 Sentence denotes 2008a) (Fig. 1).
T1129 83492-83749 Sentence denotes The cell type specific interactions between CCR5 and MOR were noted when using a bivalent ligand derivative of maraviroc linked to an opioid antagonist, naltrexone, with HIV-1 entry being significantly blocked in astrocytes but not microglia (El-Hage et al.
T1130 83750-83765 Sentence denotes 2013) (Fig. 5).
T1131 83766-83971 Sentence denotes Interestingly, maraviroc’s antiviral effects are completely negated in both astrocytes and microglia when morphine is present suggesting that maraviroc therapy may not be effective with opiate co-exposure.
T1132 83972-84265 Sentence denotes Importantly, unlike maraviroc, the bivalent compound blocked HIV entry in astrocytes irrespective of morphine treatment, while exacerbating HIV infectivity in morphine co-exposed microglia and revealing fundamental differences in the regulation of MOR and CCR5 expression in these glial types.
T1133 84266-84531 Sentence denotes Whereas, MOR and CCR5 expression appear to be similarly regulated in astrocytes, their expression patterns in microglia appear to be inversely correlated upon HIV and/or morphine exposure, with CCR5 being expressed at much higher levels than MOR (see El-Hage et al.
T1134 84532-84538 Sentence denotes 2013).
T1135 84539-84768 Sentence denotes The differential effects of the bivalent ligand in astrocytes compared to microglia might be due to the fact that the expression levels of MOR and CCR5 are differentially regulated by HIV in each of the cell types (El-Hage et al.
T1136 84769-84786 Sentence denotes 2013; Yuan et al.
T1137 84787-84806 Sentence denotes 2013; Arnatt et al.
T1138 84807-84813 Sentence denotes 2016).
T1139 84814-85098 Sentence denotes Fig. 5 Differential inhibition of HIV-1 entry into human glia by maraviroc and a bivalent CCR5-MOR antagonist (BVL) with cell-specific interactions in combination with morphine. (a) Construction of a MOR-CCR5 heterodimer model in a membrane (gray), and aqueous surrounds (red) system.
T1140 85099-85434 Sentence denotes The green protein represents MOR and the blue protein represents CCR5, while the bivalent ligand is colored in yellow. (b) Different binding pocket (green) for the triazole moiety of the bivalent ligand yellow) at 0 ns and 6.0 ns. (c) Construction of a chemical probe that interacts with both the MOR and CCR5 receptors simultaneously.
T1141 85435-85608 Sentence denotes To monitor HIV-1 infection (d) astrocytes and (e) microglia were transfected with a pBlue3′LTR-luc reporter sensitive to Tat expression and luciferase activity was measured.
T1142 85609-85750 Sentence denotes Data indicate that maraviroc’s antiviral effects are completely negated in both astrocytes and microglia when morphine is present (red bars).
T1143 85751-85873 Sentence denotes Interestingly, unlike maraviroc, the bivalent compound blocked HIV entry in astrocytes irrespective of morphine treatment.
T1144 85874-85991 Sentence denotes By contrast, the bivalent antagonist exacerbated HIV infectivity in microglia in the presence of morphine (red bars).
T1145 85992-86160 Sentence denotes The findings reveal fundamental differences in co-regulation of MOR and CCR5 expression in astroglia and microglia upon HIV and/or morphine exposure (see El-Hage et al.
T1146 86161-86167 Sentence denotes 2013).
T1147 86168-86608 Sentence denotes Values are luminescence intensity ± SEM from 3 to 5 independent experiments at 18 h post-infection (*p < 0.005 vs. un-infected cells; $p < 0.05 vs. R5 HIV-1; #p < 0.05 vs. R5 + morphine (M); ¶p < 0.05 vs. R5 + maraviroc (MVC); §p < 0.05 vs. R5 + M + MVC; ¥p < 0.05 vs. R5 + M + MVC + naltrexone). (a–b) Modified and reprinted with permission from Arnatt et al. (2016). (c–e) Modified and reprinted with permission from El-Hage et al. (2013)
T1148 86609-86918 Sentence denotes The importance of CCR5 activation in glia, but not neurons, in mediating the neurotoxic effects of morphine-dependent MOR activation is further supported in a recent study demonstrating that the loss of CCR5 from glia (but not neurons) eliminated neurotoxicity due to Tat and morphine interactions (Kim et al.
T1149 86919-86925 Sentence denotes 2018).
T1150 86926-87093 Sentence denotes Similarly, short-duration (5 d) maraviroc pre-treatment also eliminated neurotoxicity and attenuated neuronal increases in [Ca2+]i caused by Tat ± morphine (Kim et al.
T1151 87094-87100 Sentence denotes 2018).
T1152 87101-87145 Sentence denotes Selectively deleting either CCR5 (Kim et al.
T1153 87146-87170 Sentence denotes 2018) or MOR (Zou et al.
T1154 87171-87268 Sentence denotes 2011) from glia completely protects MSNs from morphine’s ability to exacerbate Tat neurotoxicity.
T1155 87269-87497 Sentence denotes However, deleting CCR5 from glia only revealed a paradoxical neuroprotective effect of morphine on Tat toxicity that is mediated by opioid receptors and appears to involve alterations in BDNF processing and signaling (Kim et al.
T1156 87498-87504 Sentence denotes 2018).
T1157 87506-87585 Sentence denotes Enhanced Mature BDNF (mBDNF) Produced by CCR5 Deficient Glia is Neuroprotective
T1158 87586-87763 Sentence denotes Mature BDNF (mBDNF) activates tyrosine receptor kinase B (TrkB) and is neuroprotective, while the precursor to BDNF, pro-BDNF, binds p75NTR and can activate cell death pathways.
T1159 87764-87920 Sentence denotes Based on findings of significant, reversible reductions in glially produced BDNF after exposure to HIV-infected cell supernatant ± morphine (Masvekar et al.
T1160 87921-87993 Sentence denotes 2014), altered BDNF processing in lymphocytes from PWH (Avdoshina et al.
T1161 87994-88053 Sentence denotes 2011), and following exposure to HIV-1 gp120 (Bachis et al.
T1162 88054-88219 Sentence denotes 2012), the pro-BDNF:mBDNF ratio was analyzed in supernatants from wild-type vs. CCR5-null striatal glial cultures exposed to Tat ± morphine for 6 or 24 h (Kim et al.
T1163 88220-88235 Sentence denotes 2018) (Fig. 6).
T1164 88236-88460 Sentence denotes CCR5-deficiency reduced this ratio by over 2-fold in cells treated with Tat and morphine after 6 h (Fig. 6), indicating a relative increase in mBDNF that may partially protect neurons in the CCR5-deficient glial environment.
T1165 88461-88599 Sentence denotes Fig. 6 Role of CCR5 and BDNF in mediating HIV-1 Tat and morphine-induced interactive cytotoxicity in striatal medium spiny neurons (MSNs).
T1166 88600-88885 Sentence denotes A proportion of glial fibrillary acidic protein (GFAP)-immunolabeled striatal astrocytes display punctate patterns of μ-opioid receptor (MOR) (a) and CCR5 (b) (43.8 ± 2.4%) immunofluorescence—with some faint immunoreactivity extending into the cell processes; scale bars = 10 μm (a-b).
T1167 88886-88974 Sentence denotes HIV-1 Tat and morphine are no longer toxic to MSNs when CCR5 is deleted from glia (c-f).
T1168 88975-89223 Sentence denotes In C57BL/J wild-type mixed glia-MSN co-cultures, Tat is neurotoxic (*p = 0.001 vs. controls), and co-exposure to morphine enhanced Tat-induced toxicity over a 72-h period (**p < 0.001 vs. controls, p < 0.05 vs. Tat) and antagonized by naloxone (c).
T1169 89224-89298 Sentence denotes Naloxone or morphine by themselves had no effect on neuronal survival (c).
T1170 89299-89523 Sentence denotes In co-cultures with CCR5-deficit glia and wild-type neurons, exposure to Tat by itself is significantly toxic (*p < 0.001 vs. controls); however, the enhanced toxicity seen with combined morphine exposure was eliminated (d).
T1171 89524-89646 Sentence denotes Unexpectedly, morphine co-treatment entirely abolished the toxic effects of Tat, restoring MSN survival to control levels.
T1172 89647-89848 Sentence denotes Pre-treatment with naloxone re-established Tat toxicity, suggesting that the paradoxical protective effects of morphine are mediated by MOR (or perhaps another opioid receptor type) (d) (see Kim et al.
T1173 89849-89855 Sentence denotes 2018).
T1174 89856-89981 Sentence denotes The neurotoxic patterns seen in CCR5-deficient MSNs and wild-type glial co-cultures are similar to wild-type co-cultures (e).
T1175 89982-90109 Sentence denotes Co-cultures in which MSNs and glia are both deficient in CCR5 are similar to those in which CCR5 is only deficient in glia (f).
T1176 90110-90236 Sentence denotes CCR5 deletion alters the expression and processing of BDNF precursor (pro-BDNF) to mature (mBDNF) by mixed-glial cultures (g).
T1177 90237-90551 Sentence denotes BDNF is expressed by both astroglia and microglia; mBDNF is neuroprotective, while pro-BDNF can promote programmed cell death. mBDNF and pro-BDNF levels were analyzed in conditioned media from wild-type or CCR5-deficient mixed glia treated with Tat ± morphine after 6 h or 24 h to assess pro-BDNF and mBDNF levels.
T1178 90552-90717 Sentence denotes The proportion of pro-BDNF/mBDNF levels was significantly higher in wild-type compared to CCR5-null glia at 24 h (lower row; g), suggesting reduced neuronal support.
T1179 90718-90920 Sentence denotes Although morphine significantly decreased pro-BDNF in CCR5-deficient glia at both 6 h and 24 h compared to control levels (not shown), the pro-BDNF/mBDNF ratios were unaltered (upper and lower rows; g).
T1180 90921-91159 Sentence denotes By contrast, combined Tat and morphine significantly decreased the pro-BDNF/mBDNF ratio at 6 h, suggesting transient protection with CCR5 deficiency that was not fully sustained at 24 h (p = 0.17) (*p < 0.05, wild-type vs. CCR5-null) (g).
T1181 91160-91243 Sentence denotes Exogenous mBDNF is neuroprotective against combined Tat and morphine treatment (h).
T1182 91244-91385 Sentence denotes Wild-type, mixed glial-MSN co-cultures were treated with mBDNF and Tat, or combined Tat and morphine (represented by dotted survival curves).
T1183 91386-91506 Sentence denotes Tat alone was neurotoxic (*p < 0.05), and Tat was significantly worsened by co-exposing MSNs to morphine (**p < 0.0001).
T1184 91507-91700 Sentence denotes The addition of mBDNF (50 ng/ml; 72 h) fully protected MSNs against combined Tat and morphine toxicity, but only tended to protect (albeit not significantly) MSNs treated with Tat alone (#)(h).
T1185 91701-92004 Sentence denotes Overall, the results in c-h suggest (1) an important role for glial CCR5 in mediating HIV-1 and opiate neurotoxic interactions, (2) that CCR5 deficiency influences signaling through MOR, and (3) that CCR5 (and perhaps MOR) act via a BDNF intermediary to promote or obstruct neuronal survival (Kim et al.
T1186 92005-92237 Sentence denotes 2018). (a-b) Modified and reprinted with permission from Podhaizer et al. (2012). (c-h) Modified and reprinted from Kim et al. (2018), which is an open access article distributed under the terms of the Creative Commons CC BY license
T1187 92238-92466 Sentence denotes Exogenous mBDNF treatment has been found to mimic the pro-survival effect of glial CCR5 deficiency against Tat ± morphine, and its neuroprotective effects have been supported in other neurodegenerative disease models (Cai et al.
T1188 92467-92482 Sentence denotes 2014; Xu et al.
T1189 92483-92489 Sentence denotes 2018).
T1190 92490-92633 Sentence denotes Collectively, the findings suggest that the loss of CCR5 may fundamentally change MOR signaling in HIV-exposed glia in a BDNF-dependent manner.
T1191 92634-92834 Sentence denotes Thus, overall the interaction of opioid and chemokine receptors, specifically MOR and CCR5, may alter the neuropathogenesis of HIV in a qualitatively unique manner not seen with either disorder alone.
T1192 92836-92880 Sentence denotes Does HIV Alter the Endogenous Opioid System?
T1193 92881-93073 Sentence denotes Little is known about the effects of HIV on the endogenous opioid system and the extent to which HIV might disrupt the expression and function of opioid peptides and receptors, and vice versa.
T1194 93074-93289 Sentence denotes Because opiate drugs act exclusively by mimicking endogenous peptides and engaging opioid receptors, it is likely that endogenous opioids also interact with HIV to some extent to affect the pathogenesis of neuroHIV.
T1195 93290-93545 Sentence denotes The endogenous opioid system comprises three originally described opioid receptors, MOR, KOR, and DOR and endogenous opioid peptide-expressing genes proopiomelanocortin (POMC), prodynorphin (PDYN), and proenkephalin (PENK) (Brownstein 1993; Trescot et al.
T1196 93546-93678 Sentence denotes 2008; Bodnar 2010; Pasternak and Pan 2013), as well as a fourth receptor (OPRN1) and peptide (nociceptin/orphanin FQ) family member.
T1197 93679-93842 Sentence denotes The endogenous opioid system has a fundamental role in pain regulation and has been implicated in the pathophysiology of various neurologic diseases (Nandhu et al.
T1198 93843-93864 Sentence denotes 2010; Sauriyal et al.
T1199 93865-93924 Sentence denotes 2011; Benarroch 2012) and in pain management (Bruehl et al.
T1200 93925-93931 Sentence denotes 2013).
T1201 93932-94037 Sentence denotes Postmortem clinical studies indicate the endogenous opioid system is disrupted in neuroHIV (Gelman et al.
T1202 94038-94058 Sentence denotes 2012; Yuferov et al.
T1203 94059-94065 Sentence denotes 2014).
T1204 94066-94142 Sentence denotes Specifically, OPRK1 mRNA is significantly upregulated in PWH (Yuferov et al.
T1205 94143-94203 Sentence denotes 2014) and in transgenic neuroHIV rodent models (Chang et al.
T1206 94204-94224 Sentence denotes 2007; Fitting et al.
T1207 94225-94373 Sentence denotes 2010b) potentially as a compensatory neuroprotective function in response to inflammatory processes in the presence of HIV infection (Yuferov et al.
T1208 94374-94380 Sentence denotes 2014).
T1209 94381-94564 Sentence denotes The upregulation of mRNA coding OPRK1 is triggered by factors released by activated macrophages and glia and is supported by mechanistic studies in dorsal root ganglia (Puehler et al.
T1210 94565-94588 Sentence denotes 2006; Gabrilovac et al.
T1211 94589-94595 Sentence denotes 2012).
T1212 94596-94814 Sentence denotes Since leukocytes, including macrophages, can express β-endorphin and enkephalins, it is important to consider the potential influence of leukocyte-derived endogenous opioid peptides in neuroinflammation (Rittner et al.
T1213 94815-94821 Sentence denotes 2001).
T1214 94822-94992 Sentence denotes Granulocytes express about 10-fold higher levels of β-endorphin, a preferential MOR and lower affinity KOR endogenous ligand, than lymphocytes (Pallinger and Csaba 2008).
T1215 94993-95089 Sentence denotes Increases in β-endorphin expression by peripheral blood mononuclear cells (PBMCs) (Gironi et al.
T1216 95090-95109 Sentence denotes 2000; Gironi et al.
T1217 95110-95178 Sentence denotes 2003), coincide with inflammation and relapse in multiple sclerosis.
T1218 95179-95529 Sentence denotes Moreover, increases in inflammatory cytokines, such as interleukin-1β (IL-1β), have been demonstrated to differentially increase the expression of proenkephalin transcripts in primary astrocytes cultured from different brain regions (Ruzicka and Akil 1997) and increase IL-10-stimulated β-endorphin expression in cultured primary microglia (Wu et al.
T1219 95530-95536 Sentence denotes 2017).
T1220 95537-95630 Sentence denotes Interestingly, OPRM1 mRNA levels do not differ between HIV+ and HIV− subjects (Yuferov et al.
T1221 95631-95637 Sentence denotes 2014).
T1222 95638-95742 Sentence denotes PENK was downregulated in brain samples from 446 PWH compared to 67 HIV negative patients (Gelman et al.
T1223 95743-95749 Sentence denotes 2012).
T1224 95750-95854 Sentence denotes The subjects with HIV also expressed higher levels of interferon regulatory factor 1 (IRF1) transcripts.
T1225 95855-96036 Sentence denotes The idea that higher opioid peptide expression levels are neuroprotective has been supported in human studies and experimental animal models (Solbrig and Koob 2004; Sarkisyan et al.
T1226 96037-96053 Sentence denotes 2015; Nam et al.
T1227 96054-96121 Sentence denotes 2019) suggesting the reductions in PENK expression are deleterious.
T1228 96122-96310 Sentence denotes The effects of HIV Tat on expression levels of opioid peptide and receptor levels depend on the individual CNS region involved as well as levels of tat transgene expression (Fitting et al.
T1229 96311-96318 Sentence denotes 2010b).
T1230 96319-96616 Sentence denotes For example, while PDYN mRNA levels were significantly reduced in the hippocampus and striatum of Tat-expressing mice, POMC was only significantly reduced by Tat induction in the striatum and PENK mRNA levels in the hippocampus were affected by chronic (but not acute) Tat exposure (Fitting et al.
T1231 96617-96624 Sentence denotes 2010b).
T1232 96625-96783 Sentence denotes Thus, HIV may alter the endogenous opioid system by modifying the expression of opioid peptides and their receptors in a brain- and cell-type specific manner.
T1233 96784-96886 Sentence denotes The consequences of HIV-1-dependent alterations in the endogenous opioid system to HAND are uncertain.
T1234 96888-96927 Sentence denotes Questions Remaining – Future Directions
T1235 96929-96984 Sentence denotes Modeling the Pharmacology of Opioid Self-Administration
T1236 96985-97207 Sentence denotes Opiate self-administration as seen with addiction can have different CNS consequences than “steady-state” (e.g., continuous via a pump or time-release drug implant) exposure to the same drug (Kreek 1987, 2001; Kreek et al.
T1237 97208-97323 Sentence denotes 2002), and we predict the pharmacokinetic differences in opiate exposure will markedly impact neuroHIV progression.
T1238 97324-97579 Sentence denotes Differential effects based on “on-off” and “steady-state” drug administration schedules have been reported for the stress-responsive hypothalamic-pituitary-adrenal (HPA) axis, the endogenous opioid system, and the dopamine system (Kreek 1973; Kreek et al.
T1239 97580-97599 Sentence denotes 2002; George et al.
T1240 97600-97606 Sentence denotes 2012).
T1241 97607-97801 Sentence denotes Acute opiate exposure typically activates the HPA axis, corticotropin releasing factor, and peripheral steroidogenesis in a species-dependent manner (Koob and Kreek 2007; Cleck and Blendy 2008).
T1242 97802-97928 Sentence denotes Alternatively, chronic self-administration of short-acting opiates suppresses diurnal cortisol rhythmicity (Facchinetti et al.
T1243 97929-97947 Sentence denotes 1984; Vuong et al.
T1244 97948-98069 Sentence denotes 2010), while opiate withdrawal typically evokes HPA activation (Culpepper-Morgan and Kreek 1997; Kreek 2007; Paris et al.
T1245 98070-98076 Sentence denotes 2020).
T1246 98077-98267 Sentence denotes The daily, repeated bouts of relative withdrawal seen with opiate addiction cause sustained HPA activation, stress (Koob and Kreek 2007; Koob 2020), and immune suppression (Eisenstein 2019).
T1247 98268-98419 Sentence denotes Importantly, maintenance therapy with the long-acting drug methadone achieves steady-dose opiate levels and normalization of the HPA axis (Kreek 1973).
T1248 98420-98552 Sentence denotes Further, it is known that HIV infection significantly alters the HPA axis, due to CNS toxicity and cytokine production (Costa et al.
T1249 98553-98611 Sentence denotes 2000; George and Bhangoo 2013; Chrousos and Zapanti 2014).
T1250 98612-98793 Sentence denotes Additionally, the nature of opiate exposure in the context of neuroHIV needs to be considered as it may induce different outcomes on neurotransmitter metabolism and gene expression.
T1251 98794-98937 Sentence denotes Specifically, the NAc shell demonstrates molecular and structural changes associated with intravenous heroin self-administration (Jacobs et al.
T1252 98938-98944 Sentence denotes 2005).
T1253 98945-99252 Sentence denotes Moreover, earlier studies have reported differential alterations in the turnover rates of various neurotransmitters for active versus passive morphine administration, including dopamine, serotonin, γ-aminobutyric acid (GABA), acetylcholine, aspartate, and glutamate during exposure to morphine (Smith et al.
T1254 99253-99265 Sentence denotes 1982, 1984).
T1255 99266-99544 Sentence denotes The disruptions were noticed specifically in brain regions involved in reinforcement processes, including the NAc, frontal cortex, and striatum, and encompassed increased dopamine and norepinephrine levels and turnover, which are central in opiate reward processes (Smith et al.
T1256 99545-99551 Sentence denotes 1982).
T1257 99552-99793 Sentence denotes Heroin abuse is known to downregulate dopaminergic activity in the NAc and may reflect a compensatory reduction in of dopamine biosynthesis in response to excessive dopaminergic stimulation resulting from chronic opiate exposure (Kish et al.
T1258 99794-99800 Sentence denotes 2001).
T1259 99801-99885 Sentence denotes Additionally, HIV is known to interfere with dopamine neurotransmission (Nath et al.
T1260 99886-99907 Sentence denotes 2000b; Gaskill et al.
T1261 99908-100018 Sentence denotes 2017) causing reductions in presynaptic dopamine terminals and dopamine transport in the striatum (Wang et al.
T1262 100019-100037 Sentence denotes 2004; Chang et al.
T1263 100038-100056 Sentence denotes 2008; Midde et al.
T1264 100057-100069 Sentence denotes 2012, 2015).
T1265 100070-100232 Sentence denotes The decline in dopamine function may exacerbate opioid abuse tendencies and drug-seeking behaviors as the rewarding effects of opioids are discounted by neuroHIV.
T1266 100234-100329 Sentence denotes Opioid Substitution Therapies and the Role of Selective/Biased Agonism in neuroHIV Pathogenesis
T1267 100330-100631 Sentence denotes Although morphine, methadone, and buprenorphine all activate MOR, each can impart different signals through MOR, related to the nature and timing of their coupling to Gα, Gβγ, β-arrestin and/or regulators of G protein signaling (RGS), since each downstream effector couples into unique cell functions.
T1268 100632-100773 Sentence denotes Functional selectivity occurs at each opioid receptor type, and for most endogenous opioid peptides at all three receptor types (Gomes et al.
T1269 100774-100780 Sentence denotes 2020).
T1270 100781-101005 Sentence denotes Moreover, opioid receptors can be expressed on a subset of virtually every cell type in the CNS—with second messenger coupling to each opioid receptor type potentially being unique, cell-type specific, and context dependent.
T1271 101006-101095 Sentence denotes Thus, the “pluridimensional” (Galandrin and Bouvier 2006; Kenakin 2011; Costa-Neto et al.
T1272 101096-101330 Sentence denotes 2016) actions of any opiate at MOR are sufficiently complicated that it is not possible to predict whether, e.g., morphine, methadone or buprenorphine, would similarly effect any aspect of neuroHIV pathology without empirical testing.
T1273 101331-101572 Sentence denotes Despite their significant use as medication-assisted therapies for treating opioid addiction, few studies have directly compared commonly used opiate substitution therapies (Bell and Strang 2020), especially in relation to HIV (Khalsa et al.
T1274 101573-101590 Sentence denotes 2006; Choi et al.
T1275 101591-101597 Sentence denotes 2020).
T1276 101598-101727 Sentence denotes Opioid substitution therapies significantly reduce the frequency of injection drug use (Kwiatkowski and Booth 2001; Pettes et al.
T1277 101728-101783 Sentence denotes 2010), decrease HIV transmission risk (MacArthur et al.
T1278 101784-101802 Sentence denotes 2012; Platt et al.
T1279 101803-101859 Sentence denotes 2016), and reduce drug-related mortality (Mathers et al.
T1280 101860-101912 Sentence denotes 2013) and the risk of opioid overdose (Volkow et al.
T1281 101913-101919 Sentence denotes 2014).
T1282 101920-102120 Sentence denotes Further, improved ARV outcomes among PWH have been reported with opioid substitution therapies, including the uptake and retention on ARV, medication adherence rates, and viral suppression (Low et al.
T1283 102121-102145 Sentence denotes 2016; Mukandavire et al.
T1284 102146-102152 Sentence denotes 2017).
T1285 102153-102348 Sentence denotes The two main medications used for opioid substitution therapy include methadone, a MOR full agonist, and buprenorphine, a MOR partial agonist and partial antagonist of KOR (Noble and Marie 2018).
T1286 102349-102629 Sentence denotes In comparison to methadone, buprenorphine has been shown to have fewer pharmacodynamic interactions with ARVs and causes less opioid withdrawal symptoms potentially due to its partial agonism on MOR, but also due to its high affinity and long duration of MOR binding (Walsh et al.
T1287 102630-102679 Sentence denotes 1994; McCance-Katz 2005; Whelan and Remski 2012).
T1288 102680-102801 Sentence denotes Further, differential proinflammatory and neurotoxic effects have been noted for various opioid treatments (Boland et al.
T1289 102802-102822 Sentence denotes 2014; Fitting et al.
T1290 102823-102845 Sentence denotes 2014b; Carvallo et al.
T1291 102846-102872 Sentence denotes 2015; Dutta and Roy 2015).
T1292 102873-102977 Sentence denotes In primary astrocytes, agonist-selective actions at MOR and KOR can be clearly demonstrated (Bohn et al.
T1293 102978-102999 Sentence denotes 2000; Belcheva et al.
T1294 103000-103021 Sentence denotes 2003; McLennan et al.
T1295 103022-103039 Sentence denotes 2008; Hahn et al.
T1296 103040-103194 Sentence denotes 2010), and we found that morphine, methadone, and buprenorphine differentially increase ROS and [Ca2+]i alone or following Tat co-exposure (Fitting et al.
T1297 103195-103202 Sentence denotes 2014b).
T1298 103203-103305 Sentence denotes Morphine can enhance HIV-1-induced production of cytokines and specifically chemokines (El-Hage et al.
T1299 103306-103338 Sentence denotes 2008a; Dave 2012; El-Hage et al.
T1300 103339-103504 Sentence denotes 2014), while other opioids including methadone, oxycodone, buprenorphine, and DAMGO can decrease inflammatory function and decrease monocyte migration (Boland et al.
T1301 103505-103526 Sentence denotes 2014; Carvallo et al.
T1302 103527-103559 Sentence denotes 2015; Jaureguiberry-Bravo et al.
T1303 103560-103581 Sentence denotes 2016; Chilunda et al.
T1304 103582-103588 Sentence denotes 2019).
T1305 103589-103891 Sentence denotes As most opiate drugs preferentially act via MOR, a potential explanation for differential interactive effects of opioids in the context of neuroHIV is the phenomenon of selective or “biased agonism”, such that different agonists can trigger distinct signaling events at the same receptor (Hauser et al.
T1306 103892-103898 Sentence denotes 2012).
T1307 103899-104040 Sentence denotes For example, coupling of MOR to Gα, Gβγ, and/or β-arrestin have been noted to differ depending on the MOR agonists involved (McPherson et al.
T1308 104041-104062 Sentence denotes 2010; Thompson et al.
T1309 104063-104084 Sentence denotes 2015; Burgueno et al.
T1310 104085-104091 Sentence denotes 2017).
T1311 104092-104294 Sentence denotes Physiologic outcomes of MOR activation in any cell type are determined by a bias for specific signaling pathways, the initial step of which is activation of G proteins and/or β-arrestin (Williams et al.
T1312 104295-104315 Sentence denotes 2013b; Violin et al.
T1313 104316-104339 Sentence denotes 2014; Suomivuori et al.
T1314 104340-104346 Sentence denotes 2020).
T1315 104347-104516 Sentence denotes The subcellular organization of GPCR signaling transduced by heterotrimeric G proteins and β-arrestin has been recently reviewed in detail (Eichel and von Zastrow 2018).
T1316 104517-104715 Sentence denotes In the context of HIV, it has been shown that selective MOR agonists such as endomorphin-1, but not DAMGO or morphine, significantly increase HIV-1 replication in infected microglia (Peterson et al.
T1317 104716-104722 Sentence denotes 1999).
T1318 104723-104940 Sentence denotes This effect might be due to an apparent bias of endomorphin-1 towards arrestin recruitment and receptor phosphorylation, which was significantly correlated with agonist-induced internalization of MOR (McPherson et al.
T1319 104941-104947 Sentence denotes 2010).
T1320 104948-105188 Sentence denotes It is suggested that ligands that display bias towards G protein-mediated pathways and away from β-arrestin 2 recruitment may have improved therapeutic profiles against the development of tolerance and dependence/addiction (McPherson et al.
T1321 105189-105195 Sentence denotes 2010).
T1322 105197-105268 Sentence denotes Opioid Effects on Antiretroviral Efficacy within the CNS and Vice Versa
T1323 105269-105342 Sentence denotes Opioid misuse has been linked to poor adherence to cART (Jeevanjee et al.
T1324 105343-105349 Sentence denotes 2014).
T1325 105350-105454 Sentence denotes However, adherence to ARV therapy improves after initiation of opioid substitution therapy (Nosyk et al.
T1326 105455-105471 Sentence denotes 2015; Low et al.
T1327 105472-105490 Sentence denotes 2016; Adams et al.
T1328 105491-105497 Sentence denotes 2020).
T1329 105498-105712 Sentence denotes Although better adherence can improve therapeutic outcomes in PWH, little information is currently available on the interaction between opioids or opioid substitution therapies and cART specifically within the CNS.
T1330 105713-105821 Sentence denotes There are several known drug-drug interactions between opioids and ARVs that affect systemic concentrations.
T1331 105822-105927 Sentence denotes The partial opioid agonist, buprenorphine, is metabolized primarily by cytochrome P450 (CYP) 3A4 and 2C8.
T1332 105928-106078 Sentence denotes Both buprenorphine and its active metabolite, norbuprenorphine, are glucuronidated by UDP-glucuronosyltransferase (UGT) 1A1 and then excreted in bile.
T1333 106079-106135 Sentence denotes Several ARVs inhibit or induce these metabolic pathways.
T1334 106136-106190 Sentence denotes However, not all interactions are clinically relevant.
T1335 106191-106492 Sentence denotes The boosted protease inhibitor combination, atazanavir/ritonavir, inhibits CYP 3A4 and UGT 1A1, leading to increases in overall systemic exposure of buprenorphine and norbuprenorphine and also results in symptoms of opioid excess, such as increased sedation and impaired cognition (McCance-Katz et al.
T1336 106493-106499 Sentence denotes 2007).
T1337 106500-106625 Sentence denotes Dose adjustments of buprenorphine are recommended when initiating therapy with atazanavir to avoid symptoms of opioid excess.
T1338 106626-106740 Sentence denotes Methadone is a full opioid substrate with multiple metabolic pathways, including CYP 3A4, 2B6, 2C19, 2C9, and 2D6.
T1339 106741-106833 Sentence denotes Several pharmacokinetic interactions are reported between methadone and protease inhibitors.
T1340 106834-106938 Sentence denotes However, withdrawal symptoms are rare, and therefore, dose adjustments are not recommended (Bruce et al.
T1341 106939-106959 Sentence denotes 2006; Meemken et al.
T1342 106960-106966 Sentence denotes 2015).
T1343 106967-107131 Sentence denotes In contrast, efavirenz and nevirapine induce CYP 3A4, resulting in decreased systemic concentrations of methadone and the development of opioid withdrawal symptoms.
T1344 107132-107276 Sentence denotes To avoid opioid withdrawal, increased methadone dosing is recommended when either efavirenz or nevirapine therapy is initiated (Marzolini et al.
T1345 107277-107296 Sentence denotes 2000; Clarke et al.
T1346 107297-107317 Sentence denotes 2001; Meemken et al.
T1347 107318-107324 Sentence denotes 2015).
T1348 107325-107477 Sentence denotes Oxycodone metabolism is inhibited by lopinavir/ritonavir, increasing oxycodone concentrations as well as the self-reported drug effects (Nieminen et al.
T1349 107478-107495 Sentence denotes 2010; Feng et al.
T1350 107496-107502 Sentence denotes 2017).
T1351 107503-107583 Sentence denotes The pharmacokinetic studies above focused on overall systemic exposure of drugs.
T1352 107584-107670 Sentence denotes Plasma concentrations, however, are not always accurate indicators of tissue exposure.
T1353 107671-107763 Sentence denotes Similarly, CNS drug exposure is often estimated based on drug concentrations within the CSF.
T1354 107764-107837 Sentence denotes However, CSF drug levels may not accurately predict brain concentrations.
T1355 107838-107974 Sentence denotes For many drugs with high efflux activities (e.g., substrates of P-gp), CSF tends to over-predict brain tissue concentrations (Liu et al.
T1356 107975-107994 Sentence denotes 2006; Friden et al.
T1357 107995-108015 Sentence denotes 2009; Kodaira et al.
T1358 108016-108028 Sentence denotes 2011, 2014).
T1359 108029-108133 Sentence denotes This could be due, in part, to differential expression of transporters at the blood-CSF barrier vs. BBB.
T1360 108134-108354 Sentence denotes In a study of the ARV drug amprenavir, concentrations of [14C]-amprenavir in CSF versus brain were 23.3 ± 11.2 and 3.33 ± 0.6 nCi/g, respectively, demonstrating overprediction of brain concentrations by CSF (Polli et al.
T1361 108355-108361 Sentence denotes 1999).
T1362 108362-108488 Sentence denotes These studies illustrate the high likelihood of misinterpreting drug brain penetration when using CSF as the surrogate marker.
T1363 108489-108683 Sentence denotes Therefore, direct measurement of brain tissue concentrations in animal models are likely to be more predictive of the interactive effects of ARVs and opioids on ARV and/or opioid brain exposure.
T1364 108684-108801 Sentence denotes A few studies have investigated the impact of opioids and ARV administration on drug concentrations within the brain.
T1365 108802-109083 Sentence denotes One study investigated the impact of 5 d continuous exposure to morphine on ARV brain concentrations (dolutegravir, lamivudine and abacavir) and demonstrated that morphine exposure resulted in regionally specific decreases in the concentrations of select ARV drugs (Leibrand et al.
T1366 109084-109272 Sentence denotes 2019) and, furthermore, that the decreases in ARV concentrations (dolutegravir and abacavir) were likely due to increased efflux by the drug efflux transport protein, P-gp (Leibrand et al.
T1367 109273-109279 Sentence denotes 2019).
T1368 109280-109384 Sentence denotes Morphine alterations in P-gp within the brain could have wide reaching impact on other CNS active drugs.
T1369 109385-109555 Sentence denotes HIV preferentially infects microglia and perivascular macrophages within the brain, although BMECs, astrocytes, and pericytes can also be infected (Kramer-Hammerle et al.
T1370 109556-109562 Sentence denotes 2005).
T1371 109563-109654 Sentence denotes Achieving optimal intracellular ARV concentrations are essential to suppress the infection.
T1372 109655-109814 Sentence denotes Few studies have examined whether ARV drugs differentially accumulate within different neural cell types and especially within cells of the neurovascular unit.
T1373 109815-110133 Sentence denotes Although nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are efficacious in inhibiting viral replication within monocyte-derived macrophages, only a few drugs within each ARV class can effectively inhibit viral replication within astrocytes (Gray et al.
T1374 110134-110218 Sentence denotes 2013), which could be a result of poor intracellular accumulation within astrocytes.
T1375 110219-110413 Sentence denotes In vitro studies have demonstrated darunavir and raltegravir intracellular concentrations to be approximately 100-fold lower (with higher EC50 values) in microglia than in PBMCs (Asahchop et al.
T1376 110414-110420 Sentence denotes 2017).
T1377 110421-110591 Sentence denotes Another study measured intracellular concentrations of dolutegravir, tenofovir and emtricitabine in primary human astrocytes, microglia, pericytes and BMECs (Patel et al.
T1378 110592-110598 Sentence denotes 2019).
T1379 110599-110712 Sentence denotes Intracellular ARV concentrations were typically significantly higher in BMECs than in the other brain cell types.
T1380 110713-110847 Sentence denotes Dolutegravir achieved the highest relative concentrations within each cell type, whereas tenofovir accumulated the least (Patel et al.
T1381 110848-110854 Sentence denotes 2019).
T1382 110855-111004 Sentence denotes Furthermore, 24 h treatment with morphine significantly decreased intracellular accumulation of composite ARV concentrations, but only in astrocytes.
T1383 111005-111124 Sentence denotes In contrast, morphine exposure significantly increased the net accumulation of drugs within BMECs compared to controls.
T1384 111125-111194 Sentence denotes BMECs may sequester ARV drugs as a protective mechanism (Patel et al.
T1385 111195-111201 Sentence denotes 2019).
T1386 111202-111480 Sentence denotes Using experimental data from SIV-infected, morphine-addicted macaques, mathematical modeling suggests that morphine exposure increases the proportion of cells with high susceptibility to SIV infection, at least in part, because of increased co-receptor expression (Vaidya et al.
T1387 111481-111487 Sentence denotes 2016).
T1388 111488-111754 Sentence denotes In addition to promoting a higher steady state viral loads and larger CD4 count declines, the model also predicts that morphine exposure results in the need for more efficacious ARV treatment than would be necessary for animals not exposed to morphine (Vaidya et al.
T1389 111755-111761 Sentence denotes 2016).
T1390 111762-111927 Sentence denotes Although the direct impact of morphine on ARV concentrations was not investigated, the study provides evidence supporting morphine’s negative impact on ARV efficacy.
T1391 111929-111945 Sentence denotes Publisher’s Note
T1392 111946-112064 Sentence denotes Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
T1393 112066-112082 Sentence denotes Acknowledgements
T1394 112083-112318 Sentence denotes Portions of this review were initially presented at the Satellite Symposium of the 25th SNIP Scientific Conference entitled, “Unraveling NeuroAIDS in the Presence of Substance Use Disorder” that was sponsored and organized by NIH/NIDA.
T1395 112319-112329 Sentence denotes Co-Chairs:
T1396 112330-112380 Sentence denotes Yu (Woody) Lin and Roger Sorensen (April 10, 2019)
T1397 112382-112389 Sentence denotes Funding
T1398 112390-112576 Sentence denotes This work was supported by the National Institute on Drug Abuse: R01 DA034231 (KFH), R01 DA044855 (KFH), R01 DA045588 (KFH), R01 DA018633 (KFH), R21 DA045630 (MM), and R01 DA045596 (SF).
T1399 112578-112611 Sentence denotes Compliance with Ethical Standards
T1400 112613-112633 Sentence denotes Conflict of Interest
T1401 112634-112693 Sentence denotes The authors declare that they have no conflict of interest.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 213-229 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T2 3131-3147 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T3 4021-4043 Phenotype denotes respiratory depression http://purl.obolibrary.org/obo/HP_0002791
T4 5996-6006 Phenotype denotes drowsiness http://purl.obolibrary.org/obo/HP_0002329
T5 6012-6030 Phenotype denotes sleep disturbances http://purl.obolibrary.org/obo/HP_0002360
T6 6412-6416 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T7 6444-6456 Phenotype denotes hyperalgesia http://purl.obolibrary.org/obo/HP_0031005
T8 6630-6648 Phenotype denotes behavioral changes http://purl.obolibrary.org/obo/HP_0000708
T9 7053-7064 Phenotype denotes brain edema http://purl.obolibrary.org/obo/HP_0002181
T10 7318-7325 Phenotype denotes gliosis http://purl.obolibrary.org/obo/HP_0002171
T11 7934-7950 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T12 8161-8180 Phenotype denotes leukoencephalopathy http://purl.obolibrary.org/obo/HP_0002352
T13 8215-8230 Phenotype denotes neuronal losses http://purl.obolibrary.org/obo/HP_0002529
T14 8814-8833 Phenotype denotes leukoencephalopathy http://purl.obolibrary.org/obo/HP_0002352
T15 8913-8936 Phenotype denotes neurofibrillary tangles http://purl.obolibrary.org/obo/HP_0002185
T16 9580-9600 Phenotype denotes cognitive impairment http://purl.obolibrary.org/obo/HP_0100543
T17 12826-12830 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T18 12852-12875 Phenotype denotes peripheral neuropathies http://purl.obolibrary.org/obo/HP_0009830
T19 13840-13857 Phenotype denotes immune deficiency http://purl.obolibrary.org/obo/HP_0002721
T20 15208-15220 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T21 15592-15616 Phenotype denotes opportunistic infections http://purl.obolibrary.org/obo/HP_0031690
T22 15684-15692 Phenotype denotes dementia http://purl.obolibrary.org/obo/HP_0000726
T23 16046-16066 Phenotype denotes cognitive impairment http://purl.obolibrary.org/obo/HP_0100543
T24 17108-17112 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T25 17196-17200 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T26 17417-17429 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T27 18638-18654 Phenotype denotes hypersensitivity http://purl.obolibrary.org/obo/HP_0041092
T28 20966-20984 Phenotype denotes Sensory Neuropathy http://purl.obolibrary.org/obo/HP_0000763
T29 21002-21020 Phenotype denotes sensory neuropathy http://purl.obolibrary.org/obo/HP_0000763
T30 22571-22587 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T31 23504-23517 Phenotype denotes neuroblastoma http://purl.obolibrary.org/obo/HP_0003006
T32 23649-23662 Phenotype denotes demyelinating http://purl.obolibrary.org/obo/HP_0011096
T33 25278-25288 Phenotype denotes Neuropathy http://purl.obolibrary.org/obo/HP_0009830
T34 25387-25396 Phenotype denotes allodynia http://purl.obolibrary.org/obo/HP_0012533
T35 26489-26499 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T36 26603-26613 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T37 27486-27498 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T38 27538-27543 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T39 33660-33671 Phenotype denotes astrocytoma http://purl.obolibrary.org/obo/HP_0009592
T40 33889-33905 Phenotype denotes Oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T41 33985-34001 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T42 35794-35810 Phenotype denotes Oxidative Stress http://purl.obolibrary.org/obo/HP_0025464
T43 36196-36209 Phenotype denotes neuroblastoma http://purl.obolibrary.org/obo/HP_0003006
T44 36522-36538 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T45 36711-36724 Phenotype denotes neuroblastoma http://purl.obolibrary.org/obo/HP_0003006
T46 58072-58090 Phenotype denotes perivascular space http://purl.obolibrary.org/obo/HP_0012520
T47 58407-58425 Phenotype denotes perivascular space http://purl.obolibrary.org/obo/HP_0012520
T48 60609-60619 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T49 62255-62268 Phenotype denotes breast cancer http://purl.obolibrary.org/obo/HP_0003002
T50 62934-62954 Phenotype denotes cognitive impairment http://purl.obolibrary.org/obo/HP_0100543
T51 63117-63127 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T52 63189-63205 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T53 65192-65205 Phenotype denotes demyelination http://purl.obolibrary.org/obo/HP_0011096
T54 65207-65226 Phenotype denotes leukoencephalopathy http://purl.obolibrary.org/obo/HP_0002352
T55 66586-66599 Phenotype denotes demyelination http://purl.obolibrary.org/obo/HP_0011096
T56 66933-66940 Phenotype denotes gliosis http://purl.obolibrary.org/obo/HP_0002171
T57 74224-74255 Phenotype denotes severe combined immunodeficient http://purl.obolibrary.org/obo/HP_0004430
T58 75631-75646 Phenotype denotes neuronal losses http://purl.obolibrary.org/obo/HP_0002529
T59 78893-78912 Phenotype denotes addictive behaviors http://purl.obolibrary.org/obo/HP_0030858
T60 80559-80579 Phenotype denotes cognitive impairment http://purl.obolibrary.org/obo/HP_0100543
T61 92422-92447 Phenotype denotes neurodegenerative disease http://purl.obolibrary.org/obo/HP_0002180
T62 93734-93738 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T63 93894-93898 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531

2_test

Id Subject Object Predicate Lexical cue
32876803-30605448-62957820 2710-2714 30605448 denotes 2018
32876803-12394784-62957821 3278-3282 12394784 denotes 2002
32876803-26106947-62957822 3405-3409 26106947 denotes 2015
32876803-27468059-62957823 3425-3429 27468059 denotes 2016
32876803-30730529-62957824 3610-3614 30730529 denotes 2019
32876803-31420089-62957825 4264-4268 31420089 denotes 2020
32876803-25581144-62957826 4815-4819 25581144 denotes 2015
32876803-25581144-62957827 5106-5110 25581144 denotes 2015
32876803-9771273-62957828 5944-5948 9771273 denotes 1998
32876803-10937910-62957829 5959-5963 10937910 denotes 2000
32876803-11773191-62957830 5989-5993 11773191 denotes 2002
32876803-11863402-62957831 6051-6055 11863402 denotes 2002
32876803-15023109-62957832 6074-6078 15023109 denotes 2004
32876803-11920548-62957833 6187-6191 11920548 denotes 2002
32876803-15297954-62957834 6206-6210 15297954 denotes 2004
32876803-26289681-62957835 6323-6327 26289681 denotes 2015
32876803-30314567-62957836 6344-6348 30314567 denotes 2018
32876803-30359116-62957837 6365-6369 30359116 denotes 2019
32876803-31806085-62957838 6387-6391 31806085 denotes 2020
32876803-16160707-62957839 6599-6603 16160707 denotes 2006
32876803-31477236-62957840 6619-6623 31477236 denotes 2020
32876803-20558415-62957841 6888-6892 20558415 denotes 2010
32876803-26289681-62957842 6908-6912 26289681 denotes 2015
32876803-26276628-62957843 6933-6937 26276628 denotes 2015
32876803-27475769-62957844 6955-6959 27475769 denotes 2016
32876803-31806085-62957845 6977-6981 31806085 denotes 2020
32876803-20946118-62957846 7074-7078 20946118 denotes 2011
32876803-8781664-62957847 7159-7163 8781664 denotes 1996
32876803-10564526-62957848 7233-7237 10564526 denotes 1999
32876803-15885069-62957849 7254-7258 15885069 denotes 2005
32876803-25868590-62957850 7298-7302 25868590 denotes 2006
32876803-19038328-62957851 7487-7491 19038328 denotes 2009
32876803-15234476-62957852 7624-7628 15234476 denotes 2004
32876803-19017525-62957853 7713-7717 19017525 denotes 2009
32876803-8747755-62957854 7854-7858 8747755 denotes 1995
32876803-15234476-62957855 7876-7880 15234476 denotes 2004
32876803-19017525-62957856 7892-7896 19017525 denotes 2009
32876803-25175867-62957857 8003-8007 25175867 denotes 2014
32876803-29526406-62957858 8023-8027 29526406 denotes 2018
32876803-5559439-62957859 8339-8343 5559439 denotes 1971
32876803-1247396-62957860 8361-8365 1247396 denotes 1976
32876803-8300019-62957861 8384-8388 8300019 denotes 1993
32876803-20946118-62957862 8423-8427 20946118 denotes 2011
32876803-24292887-62957863 8442-8446 24292887 denotes 2014
32876803-9732207-62957864 8647-8651 9732207 denotes 1998
32876803-9849723-62957865 8668-8672 9849723 denotes 1998
32876803-26189034-62957866 8708-8712 26189034 denotes 2015
32876803-30173319-62957867 8714-8718 30173319 denotes 2019
32876803-24292887-62957868 8753-8757 24292887 denotes 2014
32876803-28534187-62957869 8792-8796 28534187 denotes 2018
32876803-24292887-62957870 8857-8861 24292887 denotes 2014
32876803-16008828-62957871 9024-9028 16008828 denotes 2005
32876803-21126996-62957872 9045-9049 21126996 denotes 2010
32876803-26254956-62957873 9065-9069 26254956 denotes 2015
32876803-21126996-62957874 9386-9390 21126996 denotes 2010
32876803-16008828-62957875 9529-9533 16008828 denotes 2005
32876803-21126996-62957876 9550-9554 21126996 denotes 2010
32876803-26254956-62957877 9570-9574 26254956 denotes 2015
32876803-17690984-62957878 9616-9620 17690984 denotes 2007
32876803-20558415-62957879 9904-9908 20558415 denotes 2010
32876803-21070508-62957880 9922-9926 21070508 denotes 2012
32876803-23650554-62957881 9939-9943 23650554 denotes 2013
32876803-25035700-62957882 9958-9962 25035700 denotes 2014
32876803-26794650-62957883 9974-9978 26794650 denotes 2016
32876803-28424016-62957884 9993-9997 28424016 denotes 2017
32876803-16407899-62957885 10345-10349 16407899 denotes 2006
32876803-18706994-62957886 10369-10373 18706994 denotes 2008
32876803-18938237-62957887 10375-10379 18938237 denotes 2009
32876803-16407899-62957888 10548-10552 16407899 denotes 2006
32876803-16407899-62957889 10717-10721 16407899 denotes 2006
32876803-18938237-62957890 10741-10745 18938237 denotes 2009
32876803-20519536-62957891 10758-10762 20519536 denotes 2010
32876803-1665190-62957892 10891-10895 1665190 denotes 1991
32876803-1318509-62957893 10913-10917 1318509 denotes 1992
32876803-8149585-62957894 10940-10944 8149585 denotes 1993
32876803-8930364-62957895 10982-10986 8930364 denotes 1993
32876803-30662412-62957896 11051-11055 30662412 denotes 2018
32876803-12015197-62957897 11156-11160 12015197 denotes 2002
32876803-20437553-62957898 11182-11186 20437553 denotes 2010
32876803-21434879-62957899 11208-11212 21434879 denotes 2011
32876803-18448094-62957900 11328-11332 18448094 denotes 2008
32876803-19679181-62957901 11352-11356 19679181 denotes 2010
32876803-22316499-62957902 11380-11384 22316499 denotes 2012
32876803-22895704-62957903 11404-11408 22895704 denotes 2012
32876803-27402494-62957904 11449-11453 27402494 denotes 2017
32876803-22474354-62957905 11531-11535 22474354 denotes 2012
32876803-31921165-62957906 11719-11723 31921165 denotes 2019
32876803-21850403-62957907 11881-11885 21850403 denotes 2011
32876803-22926420-62957908 11903-11907 22926420 denotes 2013
32876803-23083095-62957909 11924-11928 23083095 denotes 2013
32876803-24824631-62957910 11946-11950 24824631 denotes 2014
32876803-31921165-62957911 11963-11967 31921165 denotes 2019
32876803-9827765-62957912 12556-12560 9827765 denotes 1998
32876803-12394784-62957913 12587-12591 12394784 denotes 2002
32876803-17981630-62957914 12608-12612 17981630 denotes 2008
32876803-23392462-62957915 12627-12631 23392462 denotes 2013
32876803-15613188-62957916 12936-12940 15613188 denotes 1999
32876803-31658202-62957917 12955-12959 31658202 denotes 2019
32876803-30383590-62957918 13138-13142 30383590 denotes 2019
32876803-3041744-62957919 13259-13263 3041744 denotes 1988
32876803-1301643-62957920 13290-13294 1301643 denotes 1992
32876803-8237587-62957921 13309-13313 8237587 denotes 1993
32876803-8655291-62957922 13330-13334 8655291 denotes 1995
32876803-8985308-62957923 13348-13352 8985308 denotes 1996
32876803-22527633-62957924 13410-13414 22527633 denotes 2012
32876803-224107-62957925 13494-13498 224107 denotes 1979
32876803-6253568-62957926 13517-13521 6253568 denotes 1980
32876803-6783926-62957927 13523-13527 6783926 denotes 1981
32876803-3041744-62957928 13547-13551 3041744 denotes 1988
32876803-1950728-62957929 13568-13572 1950728 denotes 1991
32876803-1950730-62957930 13607-13611 1950730 denotes 1991
32876803-9610674-62957932 13648-13652 9610674 denotes 1998
32876803-12615205-62957933 13674-13678 12615205 denotes 2003
32876803-12894165-62957934 13693-13697 12894165 denotes 2003
32876803-18040793-62957935 13710-13714 18040793 denotes 2006
32876803-18397920-62957936 13731-13735 18397920 denotes 2008
32876803-9610676-62957937 13894-13898 9610676 denotes 1998
32876803-2174676-62957938 13995-13999 2174676 denotes 1990
32876803-1460095-62957939 14001-14005 1460095 denotes 1992
32876803-8237594-62957940 14007-14011 8237594 denotes 1993
32876803-10218868-62957941 14013-14017 10218868 denotes 1999
32876803-14560041-62957942 14029-14033 14560041 denotes 2003
32876803-23682308-62957943 14129-14133 23682308 denotes 2013
32876803-27720326-62957944 14149-14153 27720326 denotes 2016
32876803-24401274-62957945 14181-14185 24401274 denotes 2014
32876803-11268344-62957946 14297-14301 11268344 denotes 2000
32876803-12615205-62957947 14323-14327 12615205 denotes 2003
32876803-12726730-62957948 14343-14347 12726730 denotes 2003
32876803-14729105-62957949 14361-14365 14729105 denotes 2004
32876803-21454526-62957950 14379-14383 21454526 denotes 2011
32876803-27720326-62957951 14399-14403 27720326 denotes 2016
32876803-12425430-62957952 14487-14491 12425430 denotes 2002
32876803-12726730-62957953 14507-14511 12726730 denotes 2003
32876803-25338959-62957954 14540-14544 25338959 denotes 2014
32876803-18040811-62957955 14638-14642 18040811 denotes 2006
32876803-9610676-62957956 15090-15094 9610676 denotes 1998
32876803-15577659-62957957 15110-15114 15577659 denotes 2004
32876803-24388495-62957958 15133-15137 24388495 denotes 2014
32876803-25834861-62957959 15139-15143 25834861 denotes 2015
32876803-9827765-62957960 15241-15245 9827765 denotes 1998
32876803-12394781-62957961 15247-15251 12394781 denotes 2002
32876803-24388495-62957962 15426-15430 24388495 denotes 2014
32876803-10945813-62957963 15787-15791 10945813 denotes 2000
32876803-20517932-62957964 15809-15813 20517932 denotes 2010
32876803-26965674-62957965 15829-15833 26965674 denotes 2016
32876803-15885069-62957966 15997-16001 15885069 denotes 2005
32876803-18040783-62957967 16015-16019 18040783 denotes 2006
32876803-17981630-62957968 16036-16040 17981630 denotes 2008
32876803-16783132-62957969 16093-16097 16783132 denotes 2006
32876803-19468837-62957970 16125-16129 19468837 denotes 2009
32876803-21725250-62957971 16143-16147 21725250 denotes 2011
32876803-29781879-62957972 16201-16205 29781879 denotes 2018
32876803-1745346-62957973 16302-16306 1745346 denotes 1991
32876803-19890760-62957974 16325-16329 19890760 denotes 2010
32876803-31259761-62957975 16354-16358 31259761 denotes 2019
32876803-15000697-62957976 16445-16449 15000697 denotes 2004
32876803-15885069-62957977 16552-16556 15885069 denotes 2005
32876803-17981630-62957978 16558-16562 17981630 denotes 2008
32876803-19519229-62957979 16621-16625 19519229 denotes 2009
32876803-21725250-62957980 16639-16643 21725250 denotes 2011
32876803-23392462-62957981 16658-16662 23392462 denotes 2013
32876803-21725250-62957982 16725-16729 21725250 denotes 2011
32876803-30383590-62957984 17331-17335 30383590 denotes 2019
32876803-24388495-62957985 17407-17411 24388495 denotes 2014
32876803-9827765-62957986 17567-17571 9827765 denotes 1998
32876803-12394781-62957987 17820-17824 12394781 denotes 2002
32876803-15885069-62957988 17913-17917 15885069 denotes 2005
32876803-15000697-62957989 18208-18212 15000697 denotes 2004
32876803-25834861-62957990 18367-18371 25834861 denotes 2015
32876803-8300019-62957991 18512-18516 8300019 denotes 1993
32876803-1938173-62957992 18734-18738 1938173 denotes 1991
32876803-23392462-62957993 18881-18885 23392462 denotes 2013
32876803-21725250-62957994 18972-18976 21725250 denotes 2011
32876803-9057169-62957995 19097-19101 9057169 denotes 1997
32876803-19890760-62957996 19196-19200 19890760 denotes 2010
32876803-29781879-62957997 19352-19356 29781879 denotes 2018
32876803-9649966-62957998 19757-19761 9649966 denotes 1998
32876803-11391170-62957999 19860-19864 11391170 denotes 2001
32876803-8112557-62958000 20076-20080 8112557 denotes 1993
32876803-30312275-62958001 20174-20178 30312275 denotes 2018
32876803-22391864-62958002 20370-20374 22391864 denotes 2012
32876803-21070507-62958003 20547-20551 21070507 denotes 2012
32876803-22457278-62958004 20656-20660 22457278 denotes 2012
32876803-23392455-62958005 20960-20964 23392455 denotes 2013
32876803-20851521-62958006 21094-21098 20851521 denotes 2010
32876803-16876224-62958007 21345-21349 16876224 denotes 2006
32876803-21431470-62958008 21517-21521 21431470 denotes 2011
32876803-17725417-62958009 21741-21745 17725417 denotes 2007
32876803-17934700-62958010 21769-21773 17934700 denotes 2008
32876803-17011009-62958013 22359-22363 17011009 denotes 2007
32876803-17064752-62958014 22518-22522 17064752 denotes 2007
32876803-24074576-62958015 22538-22542 24074576 denotes 2013
32876803-21748284-62958016 22770-22774 21748284 denotes 2011
32876803-22591370-62958017 22884-22888 22591370 denotes 2012
32876803-18247128-62958018 23744-23748 18247128 denotes 2008
32876803-20938808-62958019 23975-23979 20938808 denotes 2011
32876803-17553897-62958020 24696-24700 17553897 denotes 2007
32876803-29465625-62958021 25447-25451 29465625 denotes 2018
32876803-27039332-62958022 26117-26121 27039332 denotes 2016
32876803-18784333-62958023 26997-27001 18784333 denotes 2008
32876803-31668223-62958024 28990-28994 31668223 denotes 2019
32876803-26616417-62958025 29182-29186 26616417 denotes 2016
32876803-30700913-62958026 29202-29206 30700913 denotes 2019
32876803-25914150-62958027 29263-29267 25914150 denotes 2015
32876803-25811757-62958028 29287-29291 25811757 denotes 2015
32876803-30734905-62958029 29309-29313 30734905 denotes 2019
32876803-23772617-62958030 29385-29389 23772617 denotes 2013
32876803-16260386-62958031 29911-29915 16260386 denotes 2005
32876803-22591371-62958032 29931-29935 22591371 denotes 2012
32876803-22591368-62958033 29951-29955 22591368 denotes 2012
32876803-22666564-62958034 29970-29974 22666564 denotes 2012
32876803-25175867-62958035 29993-29997 25175867 denotes 2014
32876803-31681322-62958037 30031-30035 31681322 denotes 2019
32876803-25817054-62958038 30087-30091 25817054 denotes 2015
32876803-26167159-62958039 30105-30109 26167159 denotes 2015
32876803-25175867-62958040 30389-30393 25175867 denotes 2014
32876803-29410949-62958041 30395-30399 29410949 denotes 2018
32876803-7668162-62958042 30882-30886 7668162 denotes 1995
32876803-23682308-62958043 32410-32414 23682308 denotes 2013
32876803-27720326-62958044 32430-32434 27720326 denotes 2016
32876803-28099189-62958045 32712-32716 28099189 denotes 2017
32876803-16168488-62958046 34058-34062 16168488 denotes 2006
32876803-10218868-62958047 34511-34515 10218868 denotes 1999
32876803-24732776-62958048 34594-34598 24732776 denotes 2014
32876803-7560019-62958050 34882-34886 7560019 denotes 1995
32876803-14757849-62958051 35078-35082 14757849 denotes 2004
32876803-10665828-62958053 35491-35495 10665828 denotes 2000
32876803-2252636-62958054 36232-36236 2252636 denotes 1990
32876803-16697650-62958055 36755-36759 16697650 denotes 2006
32876803-24469921-62958056 37154-37158 24469921 denotes 2014
32876803-24732776-62958057 37392-37396 24732776 denotes 2014
32876803-18756534-62958058 37652-37656 18756534 denotes 2009
32876803-22101471-62958059 38538-38542 22101471 denotes 2012
32876803-22865725-62958060 38914-38918 22865725 denotes 2012
32876803-20578038-62958061 39487-39491 20578038 denotes 2010
32876803-28178524-62958062 41202-41206 28178524 denotes 2017
32876803-30194646-62958063 41218-41222 30194646 denotes 2019
32876803-15049431-62958064 41325-41329 15049431 denotes 2003
32876803-19743454-62958065 41348-41352 19743454 denotes 2009
32876803-21715610-62958066 41396-41400 21715610 denotes 2011
32876803-8254781-62958067 41460-41464 8254781 denotes 1994
32876803-15047828-62958068 41477-41481 15047828 denotes 2004
32876803-24965444-62958069 41493-41497 24965444 denotes 2014
32876803-24352441-62958070 41517-41521 24352441 denotes 2014
32876803-25985398-62958071 41533-41537 25985398 denotes 2015
32876803-15047828-62958072 41871-41875 15047828 denotes 2004
32876803-24965444-62958073 41887-41891 24965444 denotes 2014
32876803-25985398-62958074 41903-41907 25985398 denotes 2015
32876803-24732776-62958075 42252-42256 24732776 denotes 2014
32876803-17173547-62958076 42416-42420 17173547 denotes 2007
32876803-22591368-62958077 42422-42426 22591368 denotes 2012
32876803-25175867-62958078 42445-42449 25175867 denotes 2014
32876803-31473221-62958080 42485-42489 31473221 denotes 2019
32876803-31681322-62958081 42505-42509 31681322 denotes 2019
32876803-24732776-62958082 43221-43225 24732776 denotes 2014
32876803-22591371-62958083 43603-43607 22591371 denotes 2012
32876803-22591368-62958084 43623-43627 22591368 denotes 2012
32876803-22666564-62958085 43642-43646 22666564 denotes 2012
32876803-25175867-62958086 43665-43669 25175867 denotes 2014
32876803-1665190-62958087 43748-43752 1665190 denotes 1991
32876803-1318509-62958088 43770-43774 1318509 denotes 1992
32876803-8930364-62958089 43812-43816 8930364 denotes 1996
32876803-9610674-62958090 43854-43858 9610674 denotes 1998
32876803-11571786-62958091 43887-43891 11571786 denotes 2001
32876803-3413111-62958092 43947-43951 3413111 denotes 1988
32876803-2569236-62958093 43968-43972 2569236 denotes 1989
32876803-2224534-62958094 44008-44012 2224534 denotes 1990
32876803-1396335-62958095 44025-44029 1396335 denotes 1992
32876803-21234816-62958096 46964-46968 21234816 denotes 2011
32876803-24158495-62958097 47742-47746 24158495 denotes 2014
32876803-25610367-62958098 48563-48567 25610367 denotes 2014
32876803-16260386-62958099 49399-49403 16260386 denotes 2005
32876803-17173547-62958100 49405-49409 17173547 denotes 2007
32876803-269396-62958101 50613-50617 269396 denotes 1977
32876803-7931552-62958102 50633-50637 7931552 denotes 1994
32876803-22020140-62958103 50661-50665 22020140 denotes 2011
32876803-31887215-62958104 52853-52857 31887215 denotes 2019
32876803-28166799-62958105 53319-53323 28166799 denotes 2017
32876803-31887215-62958106 53325-53329 31887215 denotes 2019
32876803-10595922-62958107 53899-53903 10595922 denotes 1999
32876803-10931369-62958108 53918-53922 10931369 denotes 2000
32876803-22197032-62958109 54017-54021 22197032 denotes 2012
32876803-24965120-62958110 54205-54209 24965120 denotes 2014
32876803-21738771-62958111 54389-54393 21738771 denotes 2011
32876803-24629894-62958112 54409-54413 24629894 denotes 2014
32876803-28057474-62958113 54431-54435 28057474 denotes 2017
32876803-2841613-62958114 54580-54584 2841613 denotes 1988
32876803-21738771-62958115 54618-54622 21738771 denotes 2011
32876803-17105918-62958116 54794-54798 17105918 denotes 2006
32876803-10665989-62958117 55077-55081 10665989 denotes 2000
32876803-18761714-62958118 55118-55122 18761714 denotes 2008
32876803-26554626-62958119 55245-55249 26554626 denotes 2016
32876803-22845665-62958120 55317-55321 22845665 denotes 2012
32876803-26554626-62958121 55337-55341 26554626 denotes 2016
32876803-28057474-62958122 56409-56413 28057474 denotes 2017
32876803-8558009-62958123 59934-59938 8558009 denotes 1996
32876803-24862333-62958125 60025-60029 24862333 denotes 2014
32876803-28057474-62958126 60068-60072 28057474 denotes 2017
32876803-31473221-62958127 60090-60094 31473221 denotes 2019
32876803-27009099-62958128 60596-60600 27009099 denotes 2016
32876803-8083694-62958129 62568-62572 8083694 denotes 1994
32876803-11953468-62958130 62590-62594 11953468 denotes 2002
32876803-23876903-62958131 62608-62612 23876903 denotes 2013
32876803-19376246-62958132 62663-62667 19376246 denotes 2009
32876803-23559497-62958133 62682-62686 23559497 denotes 2013
32876803-25604843-62958134 62702-62706 25604843 denotes 2015
32876803-14970017-62958135 62820-62824 14970017 denotes 2004
32876803-22548835-62958136 62846-62850 22548835 denotes 2012
32876803-23559497-62958137 62865-62869 23559497 denotes 2013
32876803-25604843-62958138 62885-62889 25604843 denotes 2015
32876803-25604843-62958139 63042-63046 25604843 denotes 2015
32876803-16552012-62958140 63072-63076 16552012 denotes 2006
32876803-22548835-62958141 63098-63102 22548835 denotes 2012
32876803-31648680-62958142 63152-63156 31648680 denotes 2019
32876803-18247128-62958143 63262-63266 18247128 denotes 2008
32876803-25523827-62958144 63314-63318 25523827 denotes 2014
32876803-7526826-62958145 63564-63568 7526826 denotes 1994
32876803-9452009-62958146 63586-63590 9452009 denotes 1997
32876803-14557659-62958147 63605-63609 14557659 denotes 2003
32876803-14557659-62958148 63694-63698 14557659 denotes 2003
32876803-18756534-62958149 63714-63718 18756534 denotes 2009
32876803-1657038-62958150 63977-63981 1657038 denotes 1991
32876803-8599205-62958151 63999-64003 8599205 denotes 1996
32876803-19185416-62958152 64026-64030 19185416 denotes 2009
32876803-10718533-62958153 64241-64245 10718533 denotes 1999
32876803-18756534-62958154 64323-64327 18756534 denotes 2009
32876803-31442414-62958155 64360-64364 31442414 denotes 2019
32876803-26469251-62958156 64439-64443 26469251 denotes 2015
32876803-31442414-62958157 64478-64482 31442414 denotes 2019
32876803-22865725-62958158 64869-64873 22865725 denotes 2012
32876803-18194689-62958159 65273-65277 18194689 denotes 2008
32876803-19151296-62958160 65294-65298 19151296 denotes 2009
32876803-20440598-62958161 65320-65324 20440598 denotes 2010
32876803-21070508-62958162 65338-65342 21070508 denotes 2012
32876803-23895765-62958163 65354-65358 23895765 denotes 2013
32876803-27739172-62958164 65461-65465 27739172 denotes 2018
32876803-29571287-62958165 65686-65690 29571287 denotes 2018
32876803-8244536-62958166 65849-65853 8244536 denotes 1993
32876803-11571786-62958167 65895-65899 11571786 denotes 2001
32876803-18381654-62958168 65916-65920 18381654 denotes 2008
32876803-25138998-62958169 65963-65967 25138998 denotes 2014
32876803-10723064-62958170 66074-66078 10723064 denotes 2000
32876803-11460271-62958171 66093-66097 11460271 denotes 2001
32876803-11571786-62958172 66120-66124 11571786 denotes 2001
32876803-11460271-62958173 66261-66265 11460271 denotes 2001
32876803-3277272-62958174 66388-66392 3277272 denotes 1988
32876803-8866743-62958175 66406-66410 8866743 denotes 1996
32876803-19376246-62958176 66424-66428 19376246 denotes 2009
32876803-22548835-62958177 66450-66454 22548835 denotes 2012
32876803-31442414-62958178 66470-66474 31442414 denotes 2019
32876803-18247128-62958179 66722-66726 18247128 denotes 2008
32876803-18247128-62958180 66902-66906 18247128 denotes 2008
32876803-18247128-62958181 66958-66962 18247128 denotes 2008
32876803-21431470-62958183 67006-67010 21431470 denotes 2011
32876803-18756534-62958184 67233-67237 18756534 denotes 2009
32876803-11571786-62958185 67304-67308 11571786 denotes 2001
32876803-18756534-62958186 67338-67342 18756534 denotes 2009
32876803-18090275-62958187 67606-67610 18090275 denotes 2007
32876803-28099189-62958188 67650-67654 28099189 denotes 2017
32876803-8178451-62958189 67694-67698 8178451 denotes 1994
32876803-18090275-62958190 67720-67724 18090275 denotes 2007
32876803-8267293-62958191 67768-67772 8267293 denotes 1993
32876803-8254781-62958192 67791-67795 8254781 denotes 1994
32876803-29464785-62958193 67810-67814 29464785 denotes 2018
32876803-25175867-62958194 67871-67875 25175867 denotes 2014
32876803-30899112-62958195 67894-67898 30899112 denotes 2019
32876803-11818490-62958196 68013-68017 11818490 denotes 2002
32876803-30700913-62958197 68033-68037 30700913 denotes 2019
32876803-11556545-62958198 68199-68203 11556545 denotes 2001
32876803-16055948-62958199 68225-68229 16055948 denotes 2005
32876803-28099189-62958200 68669-68673 28099189 denotes 2017
32876803-18371353-62958201 68849-68853 18371353 denotes 2007
32876803-30314515-62958202 68889-68893 30314515 denotes 2018
32876803-16842084-62958203 68950-68954 16842084 denotes 2006
32876803-21637744-62958204 68998-69002 21637744 denotes 2011
32876803-25134912-62958205 69023-69027 25134912 denotes 2014
32876803-25175867-62958206 69046-69050 25175867 denotes 2014
32876803-30899112-62958207 69069-69073 30899112 denotes 2019
32876803-18177992-62958208 69385-69389 18177992 denotes 2008
32876803-27807176-62958209 69462-69466 27807176 denotes 2016
32876803-18371353-62958210 69588-69592 18371353 denotes 2007
32876803-24469921-62958211 70178-70182 24469921 denotes 2014
32876803-29410949-62958212 70338-70342 29410949 denotes 2018
32876803-22865725-62958213 71597-71601 22865725 denotes 2012
32876803-22865725-62958214 71813-71817 22865725 denotes 2012
32876803-28099189-62958215 72092-72096 28099189 denotes 2017
32876803-22865725-62958216 72155-72159 22865725 denotes 2012
32876803-28099189-62958217 72217-72221 28099189 denotes 2017
32876803-24469921-62958218 72560-72564 24469921 denotes 2014
32876803-23758766-62958219 73118-73122 23758766 denotes 2013
32876803-22457278-62958220 73178-73182 22457278 denotes 2012
32876803-8889672-62958221 73218-73222 8889672 denotes 1996
32876803-12405865-62958222 73235-73239 12405865 denotes 2002
32876803-15966752-62958223 73261-73265 15966752 denotes 2005
32876803-28263461-62958224 73276-73280 28263461 denotes 2017
32876803-28723731-62958225 73297-73301 28723731 denotes 2017
32876803-12077205-62958226 73328-73332 12077205 denotes 2002
32876803-20543610-62958227 73352-73356 20543610 denotes 2010
32876803-25159623-62958228 73372-73376 25159623 denotes 2014
32876803-30712401-62958229 73393-73397 30712401 denotes 2019
32876803-16374210-62958230 73724-73728 16374210 denotes 2006
32876803-18403767-62958231 73744-73748 18403767 denotes 2008
32876803-20517932-62958232 73954-73958 20517932 denotes 2010
32876803-23758766-62958233 73971-73975 23758766 denotes 2013
32876803-18829958-62958234 74404-74408 18829958 denotes 2008
32876803-23758766-62958235 74410-74414 23758766 denotes 2013
32876803-18074388-62958236 74574-74578 18074388 denotes 2008
32876803-23758766-62958237 74591-74595 23758766 denotes 2013
32876803-14963162-62958238 74653-74657 14963162 denotes 2004
32876803-18829958-62958239 74670-74674 18829958 denotes 2008
32876803-14963162-62958240 75037-75041 14963162 denotes 2004
32876803-18829958-62958241 75054-75058 18829958 denotes 2008
32876803-17166900-62958242 75436-75440 17166900 denotes 2007
32876803-22101471-62958244 76252-76256 22101471 denotes 2012
32876803-28099189-62958245 76274-76278 28099189 denotes 2017
32876803-8898752-62958247 77470-77474 8898752 denotes 1996
32876803-8756719-62958248 77487-77491 8756719 denotes 1996
32876803-9252328-62958249 77674-77678 9252328 denotes 1997
32876803-9500612-62958250 77697-77701 9500612 denotes 1998
32876803-10200305-62958251 77721-77725 10200305 denotes 1999
32876803-11125885-62958252 77744-77748 11125885 denotes 2000
32876803-9430590-62958253 77778-77782 9430590 denotes 1998
32876803-17651505-62958254 77927-77931 17651505 denotes 2007
32876803-19190524-62958255 77951-77955 19190524 denotes 2009
32876803-20505255-62958256 77968-77972 20505255 denotes 2010
32876803-21221856-62958257 77991-77995 21221856 denotes 2011
32876803-22457278-62958258 78216-78220 22457278 denotes 2012
32876803-22034138-62958259 78235-78239 22034138 denotes 2012
32876803-23392455-62958260 78279-78283 23392455 denotes 2013
32876803-11338173-62958261 78406-78410 11338173 denotes 2001
32876803-15925706-62958262 78425-78429 15925706 denotes 2005
32876803-15734726-62958263 78444-78448 15734726 denotes 2005
32876803-22457278-62958265 79102-79106 22457278 denotes 2012
32876803-9131254-62958266 79195-79199 9131254 denotes 1997
32876803-17112802-62958267 79217-79221 17112802 denotes 2006
32876803-27475769-62958268 79296-79300 27475769 denotes 2016
32876803-15464147-62958269 79711-79715 15464147 denotes 2004
32876803-26011641-62958271 79750-79754 26011641 denotes 2015
32876803-20525224-62958272 80440-80444 20525224 denotes 2010
32876803-12615205-62958273 80907-80911 12615205 denotes 2003
32876803-12726730-62958274 80927-80931 12726730 denotes 2003
32876803-12972507-62958275 80946-80950 12972507 denotes 2003
32876803-22591369-62958276 80969-80973 22591369 denotes 2012
32876803-11268344-62958277 81109-81113 11268344 denotes 2000
32876803-12486875-62958278 81129-81133 12486875 denotes 2002
32876803-21454526-62958279 81147-81151 21454526 denotes 2011
32876803-12413885-62958280 81260-81264 12413885 denotes 2002
32876803-14729105-62958281 81278-81282 14729105 denotes 2004
32876803-9670044-62958282 81432-81436 9670044 denotes 1998
32876803-12972507-62958283 81451-81455 12972507 denotes 2003
32876803-14729105-62958284 81469-81473 14729105 denotes 2004
32876803-21454526-62958285 81616-81620 21454526 denotes 2011
32876803-15893700-62958286 81796-81800 15893700 denotes 2005
32876803-12726730-62958287 82064-82068 12726730 denotes 2003
32876803-23682308-62958288 84787-84791 23682308 denotes 2013
32876803-27720326-62958289 84807-84811 27720326 denotes 2016
32876803-27720326-62958290 86530-86534 27720326 denotes 2016
32876803-24949623-62958291 87921-87925 24949623 denotes 2014
32876803-21422985-62958292 87994-87998 21422985 denotes 2011
32876803-22787033-62958293 88054-88058 22787033 denotes 2012
32876803-22101471-62958294 92080-92084 22101471 denotes 2012
32876803-24818146-62958295 92467-92471 24818146 denotes 2014
32876803-30323150-62958296 92483-92487 30323150 denotes 2018
32876803-8390660-62958297 93525-93529 8390660 denotes 1993
32876803-18443637-62958298 93546-93550 18443637 denotes 2008
32876803-20875476-62958299 93559-93563 20875476 denotes 2010
32876803-24076545-62958300 93583-93587 24076545 denotes 2013
32876803-20734417-62958301 93843-93847 20734417 denotes 2010
32876803-21208657-62958302 93865-93869 21208657 denotes 2011
32876803-22915176-62958303 93881-93885 22915176 denotes 2012
32876803-23374939-62958304 93925-93929 23374939 denotes 2013
32876803-22391864-62958305 94038-94042 22391864 denotes 2012
32876803-24405578-62958306 94059-94063 24405578 denotes 2014
32876803-24405578-62958307 94143-94147 24405578 denotes 2014
32876803-17553897-62958308 94204-94208 17553897 denotes 2007
32876803-24405578-62958309 94374-94378 24405578 denotes 2014
32876803-11506126-62958310 94815-94819 11506126 denotes 2001
32876803-18005034-62958311 94986-94990 18005034 denotes 2008
32876803-29084866-62958312 95530-95534 29084866 denotes 2017
32876803-24405578-62958313 95631-95635 24405578 denotes 2014
32876803-22391864-62958314 95743-95747 22391864 denotes 2012
32876803-15102496-62958315 96014-96018 15102496 denotes 2004
32876803-26029055-62958316 96037-96041 26029055 denotes 2015
32876803-31132785-62958317 96054-96058 31132785 denotes 2019
32876803-3125471-62958318 97183-97187 3125471 denotes 1987
32876803-11458539-62958319 97189-97193 11458539 denotes 2001
32876803-12209151-62958320 97208-97212 12209151 denotes 2002
32876803-4739193-62958321 97561-97565 4739193 denotes 1973
32876803-12209151-62958322 97580-97584 12209151 denotes 2002
32876803-22108506-62958323 97600-97604 22108506 denotes 2012
32876803-17671276-62958324 97772-97776 17671276 denotes 2007
32876803-18246196-62958325 97795-97799 18246196 denotes 2008
32876803-6320568-62958326 97929-97933 6320568 denotes 1984
32876803-19903933-62958327 97948-97952 19903933 denotes 2010
32876803-9030816-62958328 98039-98043 9030816 denotes 1997
32876803-18286797-62958329 98051-98055 18286797 denotes 2007
32876803-17671276-62958330 98208-98212 17671276 denotes 2007
32876803-31400808-62958331 98219-98223 31400808 denotes 2020
32876803-31921165-62958332 98261-98265 31921165 denotes 2019
32876803-4739193-62958333 98413-98417 4739193 denotes 1973
32876803-11085902-62958334 98553-98557 11085902 denotes 2000
32876803-23728720-62958335 98578-98582 23728720 denotes 2013
32876803-15849023-62958336 98938-98942 15849023 denotes 2005
32876803-6123120-62958337 99253-99257 6123120 denotes 1982
32876803-6538688-62958338 99259-99263 6538688 denotes 1984
32876803-6123120-62958339 99545-99549 6123120 denotes 1982
32876803-11282256-62958340 99794-99798 11282256 denotes 2001
32876803-15319273-62958342 100019-100023 15319273 denotes 2004
32876803-18579413-62958343 100038-100042 18579413 denotes 2008
32876803-21030484-62958344 101072-101076 21030484 denotes 2011
32876803-27638872-62958345 101096-101100 27638872 denotes 2016
32876803-31420089-62958346 101521-101525 31420089 denotes 2020
32876803-17109302-62958347 101573-101577 17109302 denotes 2006
32876803-11391170-62958348 101708-101712 11391170 denotes 2001
32876803-23038795-62958349 101784-101788 23038795 denotes 2012
32876803-23554523-62958350 101860-101864 23554523 denotes 2013
32876803-24758595-62958351 101913-101917 24758595 denotes 2014
32876803-27343545-62958352 102121-102125 27343545 denotes 2016
32876803-28323752-62958353 102146-102150 28323752 denotes 2017
32876803-30713510-62958354 102342-102346 30713510 denotes 2018
32876803-8181201-62958355 102630-102634 8181201 denotes 1994
32876803-16265622-62958356 102649-102653 16265622 denotes 2005
32876803-22346191-62958357 102673-102677 22346191 denotes 2012
32876803-24644198-62958358 102802-102806 24644198 denotes 2014
32876803-25716997-62958359 102846-102850 25716997 denotes 2015
32876803-19895666-62958360 103040-103044 19895666 denotes 2010
32876803-22066570-62958361 103318-103322 22066570 denotes 2012
32876803-24732776-62958362 103339-103343 24732776 denotes 2014
32876803-24644198-62958363 103505-103509 24644198 denotes 2014
32876803-25716997-62958364 103527-103531 25716997 denotes 2015
32876803-27009099-62958365 103560-103564 27009099 denotes 2016
32876803-31473221-62958366 103582-103586 31473221 denotes 2019
32876803-22591368-62958367 103892-103896 22591368 denotes 2012
32876803-20647394-62958368 104041-104045 20647394 denotes 2010
32876803-24460711-62958369 104063-104067 24460711 denotes 2015
32876803-24878326-62958370 104316-104320 24878326 denotes 2014
32876803-32079767-62958371 104340-104344 32079767 denotes 2020
32876803-29478570-62958372 104510-104514 29478570 denotes 2018
32876803-10218868-62958373 104716-104720 10218868 denotes 1999
32876803-20647394-62958374 104941-104945 20647394 denotes 2010
32876803-20647394-62958375 105189-105193 20647394 denotes 2010
32876803-24077929-62958376 105343-105347 24077929 denotes 2014
32876803-25915170-62958377 105455-105459 25915170 denotes 2015
32876803-27343545-62958378 105472-105476 27343545 denotes 2016
32876803-31711873-62958379 105491-105495 31711873 denotes 2020
32876803-17643869-62958380 106493-106497 17643869 denotes 2007
32876803-17109308-62958381 106939-106943 17109308 denotes 2006
32876803-25902733-62958382 106960-106964 25902733 denotes 2015
32876803-10894303-62958383 107277-107281 10894303 denotes 2000
32876803-11298066-62958384 107297-107301 11298066 denotes 2001
32876803-25902733-62958385 107318-107322 25902733 denotes 2015
32876803-20697700-62958386 107478-107482 20697700 denotes 2010
32876803-28579821-62958387 107496-107500 28579821 denotes 2017
32876803-16760229-62958388 107975-107979 16760229 denotes 2006
32876803-19764786-62958389 107995-107999 19764786 denotes 2009
32876803-24644297-62958390 108022-108026 24644297 denotes 2014
32876803-10468021-62958391 108355-108359 10468021 denotes 1999
32876803-15885841-62958392 109556-109560 15885841 denotes 2005
32876803-23614033-62958393 110134-110138 23614033 denotes 2013
32876803-29037245-62958394 110414-110418 29037245 denotes 2017
32876803-27668463-62958395 111481-111485 27668463 denotes 2016
32876803-27668463-62958396 111755-111759 27668463 denotes 2016