PMC:7461420 / 99885-100693
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 0-4 | Body_part | denotes | Shin | http://purl.org/sig/ont/fma/fma24985 |
| T2 | 575-583 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T496 | 540-559 | Disease | denotes | malignant neoplasms | http://purl.obolibrary.org/obo/MONDO_0004992|http://purl.obolibrary.org/obo/MONDO_0006517 |
| T498 | 649-653 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-22 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T2 | 144-145 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T3 | 292-300 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T4 | 419-427 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T5 | 466-467 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T6 | 564-567 | http://purl.obolibrary.org/obo/CLO_0009132 | denotes | Src |
| T7 | 797-807 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T88002 | 74-83 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T9851 | 101-110 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T67871 | 224-238 | Chemical | denotes | antipsychotics | http://purl.obolibrary.org/obo/CHEBI_35476 |
| T12849 | 255-269 | Chemical | denotes | antidepressant | http://purl.obolibrary.org/obo/CHEBI_35469 |
| T13 | 474-482 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T63941 | 483-487 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T81847 | 575-583 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
| T1649 | 787-796 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 3082 | 129-137 | Species | denotes | MERS‐CoV | Tax:1335626 |
| 3083 | 636-640 | Species | denotes | CoVs | Tax:11118 |
| 3084 | 649-657 | Species | denotes | SARS‐CoV | Tax:694009 |
| 3085 | 676-685 | Species | denotes | HCoV‐229E | Tax:11137 |
| 3086 | 706-710 | Species | denotes | FIPV | Tax:11135 |
| 3087 | 410-418 | Species | denotes | MERS‐CoV | Tax:1335626 |
| 3088 | 338-349 | Chemical | denotes | Saracatinib | MESH:C515233 |
| 3089 | 540-559 | Disease | denotes | malignant neoplasms | MESH:D009369 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T883 | 0-138 | Sentence | denotes | Shin et al. analyzed a library of 2334 approved medications and bioactive molecules to find possible antiviral compounds against MERS‐CoV. |
| T884 | 139-337 | Sentence | denotes | 259 A series of hit compounds was identified, categorized as anticancer (189, 190), antipsychotics (191, 192), and antidepressant (193) with inhibition activity between 2.1 and 14.4 µM (Figure 38). |
| T885 | 338-459 | Sentence | denotes | Saracatinib (189) was especially interesting, as it had remarkable anti‐MERS‐CoV activity (EC50 of 2.9 µM, CC50 > 50 µM). |
| T886 | 460-610 | Sentence | denotes | It is a small molecule drug with oral bioavailability used in the management of malignant neoplasms via Src‐family tyrosine kinases (SFKs) inhibition. |
| T887 | 611-753 | Sentence | denotes | It also suppressed other CoVs such as SARS‐CoV‐1 (EC50, 2.4 µM), HCoV‐229E (EC50, 5.1 µM), and FIPV (EC50, 7.0 µM) at nontoxic concentrations. |
| T888 | 754-808 | Sentence | denotes | Drugs 190 to 193 showed moderate antiviral activities. |