> top > docs > PMC:7461420 > spans > 81454-87311 > annotations

PMC:7461420 / 81454-87311 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T282 54-57 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T283 131-134 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T284 181-186 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T285 246-249 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T286 297-300 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T287 314-317 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T288 424-427 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T289 561-567 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T290 584-588 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T291 616-624 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T292 978-981 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T293 1509-1512 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T294 1523-1526 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T295 1631-1638 Body_part denotes adenine http://purl.org/sig/ont/fma/fma82774
T296 1812-1817 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T297 1994-2001 Body_part denotes adenine http://purl.org/sig/ont/fma/fma82774
T298 2051-2054 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T299 2434-2437 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T300 2509-2512 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T301 2726-2729 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T302 3019-3023 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T303 3343-3347 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T304 3556-3561 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T305 4190-4193 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T306 4656-4659 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T307 4728-4735 Body_part denotes guanine http://purl.org/sig/ont/fma/fma82775
T308 4874-4877 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T26 3343-3347 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T386 515-519 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T387 1261-1269 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T388 1419-1423 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T389 1539-1543 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T390 1549-1582 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T391 1738-1749 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T392 1738-1747 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T393 2127-2131 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T394 2221-2225 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T395 2875-2879 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T396 3014-3017 Disease denotes HAE http://purl.obolibrary.org/obo/MONDO_0019623
T397 3090-3094 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T398 3201-3205 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T399 3258-3262 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T400 3383-3392 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T401 3736-3741 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T402 3754-3770 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T403 3801-3805 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T404 3902-3906 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T405 4286-4302 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T406 4334-4338 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T407 4448-4456 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T408 4544-4553 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T409 5057-5065 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T410 5248-5252 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T411 5560-5568 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T412 5848-5856 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T955 181-186 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T956 203-210 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T957 250-257 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T958 306-307 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T959 428-435 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T960 502-503 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T961 584-588 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T962 1178-1181 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T963 1402-1410 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T964 1609-1610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T965 1812-1817 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T966 1935-1941 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T967 2138-2141 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T968 2181-2184 http://purl.obolibrary.org/obo/CLO_0001195 denotes 219
T969 2320-2321 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T970 2484-2485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T971 2528-2536 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T972 2540-2541 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T973 2730-2737 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T974 2989-2994 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T975 2995-3001 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T976 3002-3012 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T977 3019-3023 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T978 3048-3056 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T979 3121-3122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T980 3241-3242 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T981 3243-3248 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T982 3316-3321 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T983 3343-3347 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T984 3343-3347 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T985 3532-3533 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T986 3656-3657 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T987 3702-3705 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T988 3754-3759 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T989 3881-3882 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T990 3992-3993 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T991 4273-4274 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T992 4345-4348 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T993 4405-4408 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T994 4467-4470 http://purl.obolibrary.org/obo/CLO_0001196 denotes 225
T995 4580-4581 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T996 4611-4614 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T997 4626-4634 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T998 4643-4644 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T999 4660-4667 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T1000 4770-4776 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T1001 5030-5031 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1002 5526-5529 http://purl.obolibrary.org/obo/CLO_0001195 denotes 219
T1003 5600-5601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T62775 89-98 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T53718 463-467 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T67369 480-489 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T12231 616-624 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T84932 1095-1105 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T49879 1111-1121 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T77345 1148-1157 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T10447 1165-1176 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T7340 1211-1220 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T57667 1367-1377 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T42555 1436-1445 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T67983 1447-1456 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T36809 1462-1472 Chemical denotes sofosbuvir http://purl.obolibrary.org/obo/CHEBI_85083
T84185 1614-1619 Chemical denotes cyano http://purl.obolibrary.org/obo/CHEBI_48819
T47673 1631-1638 Chemical denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708
T55785 1641-1651 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T48934 1659-1666 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T38198 1672-1679 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T36015 1750-1754 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T9292 1755-1765 Chemical denotes sofosbuvir http://purl.obolibrary.org/obo/CHEBI_85083
T28752 1823-1838 Chemical denotes phosphoramidate http://purl.obolibrary.org/obo/CHEBI_29920
T18186 1922-1934 Chemical denotes triphosphate http://purl.obolibrary.org/obo/CHEBI_18036
T4985 1942-1952 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T75536 1964-1976 Chemical denotes triphosphate http://purl.obolibrary.org/obo/CHEBI_18036
T512 1994-2001 Chemical denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708
T2873 2204-2206 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T514 2242-2252 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T49423 2589-2592 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T31141 2790-2799 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T518 2805-2815 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T519 3038-3047 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T19063 3071-3081 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T26868 3283-3293 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T44704 3453-3463 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T523 3486-3495 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T43938 3510-3514 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T14297 3534-3540 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T87614 3592-3601 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T40579 3992-4004 Chemical denotes a nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T51217 4050-4059 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T60616 4118-4129 Chemical denotes amide group http://purl.obolibrary.org/obo/CHEBI_52901
T531 4118-4123 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T533 4124-4129 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T48363 4233-4237 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T6634 4395-4404 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T77728 4508-4522 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T9094 4508-4517 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T538 4518-4522 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T97357 4582-4594 Chemical denotes pyrazinamide http://purl.obolibrary.org/obo/CHEBI_45285
T83092 4728-4735 Chemical denotes guanine http://purl.obolibrary.org/obo/CHEBI_16235
T74794 4777-4787 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T45931 4789-4800 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T20357 4801-4814 Chemical denotes ribofuranosyl http://purl.obolibrary.org/obo/CHEBI_26565
T13775 4818-4830 Chemical denotes triphosphate http://purl.obolibrary.org/obo/CHEBI_18036
T99549 5166-5173 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T42860 5191-5201 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T44765 5363-5373 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T43256 5489-5503 Chemical denotes hydroxyl group http://purl.obolibrary.org/obo/CHEBI_43176
T79445 5489-5497 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191
T18964 5498-5503 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T39781 5511-5519 Chemical denotes cytidine http://purl.obolibrary.org/obo/CHEBI_17562
T96012 5658-5668 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T76 3-7 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T77 212-216 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T78 280-289 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T79 361-378 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycles
T80 539-543 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T81 652-665 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T82 1073-1077 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T83 1430-1434 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T84 1503-1507 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T85 1905-1914 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T86 2011-2015 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T87 2051-2064 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T88 2055-2064 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T89 2232-2236 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T90 2800-2804 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T91 3269-3281 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T92 3605-3609 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T93 4286-4302 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T94 4701-4705 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T95 4881-4885 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T96 5467-5471 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T97 5653-5657 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T20 1738-1747 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2505 3-7 Gene denotes RdRP Gene:43740578
2507 212-216 Gene denotes RdRP Gene:43740578
2510 539-543 Gene denotes RdRP Gene:43740578
2511 515-525 Species denotes SARS‐CoV‐2 Tax:2697049
2519 1073-1077 Gene denotes RdRP Gene:43740578
2520 1270-1278 Species denotes patients Tax:9606
2521 1111-1121 Chemical denotes remdesivir MESH:C000606551
2522 1129-1140 Chemical denotes galidesivir MESH:C517546
2523 1148-1157 Chemical denotes ribavirin MESH:D012254
2524 1165-1176 Chemical denotes favipiravir MESH:C462182
2525 1261-1269 Disease denotes COVID‐19 MESH:C000657245
2534 1503-1507 Gene denotes RdRP Gene:43740578
2535 1430-1434 Gene denotes RdRP Gene:43740578
2536 1419-1429 Species denotes SARS‐CoV‐2 Tax:2697049
2537 1539-1547 Species denotes SARS‐CoV Tax:694009
2538 1367-1377 Chemical denotes Nucleoside MESH:D009705
2539 1436-1445 Chemical denotes adenosine MESH:D000241
2540 1447-1456 Chemical denotes guanosine MESH:D006151
2541 1462-1472 Chemical denotes sofosbuvir MESH:D000069474
2552 1954-1957 Gene denotes RTP Gene:10397
2553 2011-2015 Gene denotes RdRP Gene:43740578
2554 1595-1605 Chemical denotes Remdesivir MESH:C000606551
2555 1611-1651 Chemical denotes 1'‐cyano‐substitued adenine C‐nucleoside
2556 1755-1765 Chemical denotes sofosbuvir MESH:D000069474
2557 1823-1838 Chemical denotes phosphoramidate MESH:C011067
2558 1922-1934 Chemical denotes triphosphate MESH:C005692
2559 1964-1976 Chemical denotes triphosphate MESH:C005692
2560 1994-2001 Chemical denotes adenine MESH:D000225
2561 1738-1749 Disease denotes hepatitis C MESH:D006526
2572 2473-2476 Gene denotes RTP Gene:10397
2573 2800-2804 Gene denotes RdRP Gene:43740578
2574 2232-2236 Gene denotes RdRP Gene:43740578
2575 2127-2137 Species denotes SARS‐CoV‐2 Tax:2697049
2576 2221-2231 Species denotes SARS‐CoV‐2 Tax:2697049
2577 2099-2109 Chemical denotes remdesivir MESH:C000606551
2578 2242-2252 Chemical denotes remdesivir MESH:C000606551
2579 2253-2266 Chemical denotes monophosphate
2580 2268-2271 Chemical denotes RMP
2581 2589-2592 Chemical denotes ATP MESH:D000255
2596 2875-2883 Species denotes SARS‐CoV Tax:694009
2597 2890-2898 Species denotes MERS‐CoV Tax:1335626
2598 2989-2994 Species denotes human Tax:9606
2599 3090-3098 Species denotes SARS‐CoV Tax:694009
2600 3105-3113 Species denotes MERS‐CoV Tax:1335626
2601 3201-3209 Species denotes SARS‐CoV Tax:694009
2602 3227-3235 Species denotes MERS‐CoV Tax:1335626
2603 3243-3248 Species denotes mouse Tax:10090
2604 3258-3266 Species denotes SARS‐CoV Tax:694009
2605 3406-3417 Species denotes respiratory Tax:12814
2606 2829-2839 Chemical denotes Remdesivir MESH:C000606551
2607 3071-3081 Chemical denotes remdesivir MESH:C000606551
2608 3283-3293 Chemical denotes remdesivir MESH:C000606551
2609 3383-3392 Disease denotes infection MESH:D007239
2623 3605-3609 Gene denotes RdRP Gene:43740578
2624 3736-3741 Species denotes Ebola Tax:1570291
2625 3811-3820 Species denotes MERS‐CoVs Tax:1335626
2626 3853-3857 Species denotes CoVs Tax:11118
2627 3902-3912 Species denotes SARS‐CoV‐2 Tax:2697049
2628 3428-3439 Chemical denotes Galidesivir MESH:C517546
2629 3451-3463 Chemical denotes C‐nucleoside
2630 3486-3495 Chemical denotes adenosine MESH:D000241
2631 3534-3540 Chemical denotes ribose MESH:D012266
2632 3552-3561 Chemical denotes aza‐sugar
2633 3592-3601 Chemical denotes adenosine MESH:D000241
2634 3690-3701 Chemical denotes Galidesivir MESH:C517546
2635 3754-3770 Disease denotes virus infections MESH:D001102
2646 4334-4344 Species denotes SARS‐CoV‐2 Tax:2697049
2647 4457-4465 Species denotes patients Tax:9606
2648 3979-3988 Chemical denotes Ribavirin MESH:D012254
2649 3994-4004 Chemical denotes nucleoside MESH:D009705
2650 4050-4059 Chemical denotes guanosine MESH:D006151
2651 4065-4074 Chemical denotes guanosine MESH:D006151
2652 4118-4123 Chemical denotes amide MESH:D000577
2653 4395-4404 Chemical denotes ribavirin MESH:D012254
2654 4286-4302 Disease denotes viral infections MESH:D001102
2655 4448-4456 Disease denotes COVID‐19 MESH:C000657245
2666 4881-4885 Gene denotes RdRP Gene:43740578
2667 4701-4705 Gene denotes RdRP Gene:43740578
2668 4544-4553 Species denotes influenza Tax:11309
2669 4471-4482 Chemical denotes Favipiravir MESH:C462182
2670 4582-4594 Chemical denotes pyrazinamide MESH:D011718
2671 4674-4685 Chemical denotes Favipiravir MESH:C462182
2672 4728-4735 Chemical denotes guanine MESH:D006147
2673 4789-4830 Chemical denotes favipiravir‐ribofuranosyl‐5'‐triphosphate
2674 4942-4952 Chemical denotes remdesivir MESH:C000606551
2675 5057-5065 Disease denotes COVID‐19 MESH:C000657245
2684 5467-5471 Gene denotes RdRP Gene:43740578
2685 5248-5258 Species denotes SARS‐CoV‐2 Tax:2697049
2686 5277-5281 Species denotes CoVs Tax:11118
2687 5569-5577 Species denotes patients Tax:9606
2688 5191-5201 Chemical denotes nucleoside MESH:D009705
2689 5363-5373 Chemical denotes remdesivir MESH:C000606551
2690 5511-5519 Chemical denotes cytidine MESH:D003562
2691 5560-5568 Disease denotes COVID‐19 MESH:C000657245
2695 5653-5657 Gene denotes RdRP Gene:43740578
2696 5622-5632 Chemical denotes Remdesivir MESH:C000606551
2697 5848-5856 Disease denotes COVID‐19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T706 0-26 Sentence denotes 4 RdRP AND ITS INHIBITORS
T707 27-130 Sentence denotes The ability to produce new RNA copies from available template molecules is necessary for life on earth.
T708 131-211 Sentence denotes RNA polymerases are therefore found in all living cells as well as many viruses.
T709 212-327 Sentence denotes RdRP are essential enzymes to all RNA viruses, as they catalyze the synthesis of new RNA from a given RNA template.
T710 328-514 Sentence denotes 206 Due to their importance for viral life cycles, and their high conservation among different RNA viruses, they have been attractive drug targets for antiviral therapy for a long time.
T711 515-589 Sentence denotes SARS‐CoV‐2 also uses an RdRP to replicate its genome within the host cell.
T712 590-716 Sentence denotes Three nonstructural viral proteins (nsp) form its replication/transcription complex, with nsp12 forming the catalytic subunit.
T713 717-798 Sentence denotes Bound to it are nsp7 and nsp8—accessory factors that facilitate template binding.
T714 799-887 Sentence denotes 207 , 208 , 209 Their individual structures and that of the complex have been solved.
T715 888-1061 Sentence denotes 210 , 211 , 212 , 213 , 214 Interestingly, the only nsp that interacts directly with RNA seems to be nsp12, whereas nsp7 and nsp8 are needed to increase its efficiency.
T716 1062-1072 Sentence denotes 210 , 215
T717 1073-1204 Sentence denotes RdRP is the target of inhibitors like remdesivir (178), galidesivir (179), ribavirin (180), favipiravir (181), and EIDD‐2801 (182).
T718 1205-1279 Sentence denotes These molecules have shown promise for the treatment of COVID‐19 patients.
T719 1280-1355 Sentence denotes 87 , 216 , 217 , 218 (For structures and biological data see Figure 38)
T720 1356-1502 Sentence denotes Figure 38 Nucleoside analogs with inhibition activity against SARS‐CoV‐2 RdRP (adenosine, guanosine, and sofosbuvir are included for comparison).
T721 1503-1667 Sentence denotes RdRP, RNA‐dependent RNA polymerase; SARS‐CoV, severe acute respiratory syndrome coronavirus Remdesivir is a 1'‐cyano‐substitued adenine C‐nucleoside analog prodrug.
T722 1668-1787 Sentence denotes The prodrug strategy used is similar to that of the FDA‐approved anti‐hepatitis C drug sofosbuvir (183; see Figure 38).
T723 1788-1959 Sentence denotes Upon its diffusion into cells, the phosphoramidate undergoes an intracellular conversion process that results in the formation of the triphosphate active metabolite (RTP).
T724 1960-2065 Sentence denotes The triphosphate is recognized as adenine by viral RdRP, which causes heavy disruptions in RNA synthesis.
T725 2066-2180 Sentence denotes The exact molecular mechanism of remdesivir's action against SARS‐CoV‐2 has recently been elucidated by Yin et al.
T726 2181-2311 Sentence denotes 219 who reported cryo‐EM structures of SARS‐CoV‐2 RdRP with remdesivir monophosphate (RMP) covalently bound to the primer strand.
T727 2312-2456 Sentence denotes As only a single RMP was incorporated in each observed primer strand the inhibition mechanism was shown to be nonobligate RNA chain termination.
T728 2457-2626 Sentence denotes The addition of RTP led to a complete inhibition of RNA polymerization activity at a concentration of 1 mM, even in the presence of ATP in high concentrations of 100 mM.
T729 2627-2828 Sentence denotes The authors further highlight the high conservation level of catalytic sites of RdRPs in different RNA viruses, which makes the discovery of future broad‐spectrum antiviral RdRP inhibitors seem likely.
T730 2829-2972 Sentence denotes Remdesivir was previously reported to inhibit SARS‐CoV‐1 and MERS‐CoV replication in multiple in vitro systems, with submicromolar IC50 values.
T731 2973-3237 Sentence denotes 220 In primary human airway epithelial (HAE) cell cultures, the antiviral activity assessment of remdesivir against SARS‐CoV‐1 and MERS‐CoV showed a dose‐dependent reduction in replication with average IC50 values of 0.069 µM (SARS‐CoV‐1) and 0.074 µM (MERS‐CoV).
T732 3238-3427 Sentence denotes In a mouse model of SARS‐CoV‐1 pathogenesis, remdesivir greatly decreased the virus concentration in the lung and mitigated clinical symptoms of infection and restored respiratory function.
T733 3428-3496 Sentence denotes Galidesivir is another C‐nucleoside analog that resembles adenosine.
T734 3497-3562 Sentence denotes However, the base is not linked to a ribose, but to an aza‐sugar.
T735 3563-3689 Sentence denotes Although it is recognized as adenosine by RdRP, its properties are different enough to cause a disruption in chain elongation.
T736 3690-3858 Sentence denotes Galidesivir has been used in the treatment of Ebola and Marburg virus infections, and in vitro studies against SARS‐ and MERS‐CoVs have suggested efficacy against CoVs.
T737 3859-3967 Sentence denotes 221 Therefore, it is a likely future anti SARS‐CoV‐2 agent, and currently being studied in clinical trials.
T738 3968-3978 Sentence denotes 222 , 223
T739 3979-4060 Sentence denotes Ribavirin is a nucleoside analog, which shows structural similarity to guanosine.
T740 4061-4130 Sentence denotes But guanosine's 6‐membered ring is only hinted at by the amide group.
T741 4131-4209 Sentence denotes As such, it is incorporated by viral RdRPs, but interrupts RNA polymerization.
T742 4210-4303 Sentence denotes 224 It is an approved drug in most countries and used against a variety of viral infections.
T743 4304-4466 Sentence denotes Although its efficacy against SARS‐CoV‐2 has not been determined in large clinical trials, ribavirin has shown some promise in the treatment of COVID‐19 patients.
T744 4467-4470 Sentence denotes 225
T745 4471-4573 Sentence denotes Favipiravir (Avigan®) is an approved antiviral drug for the treatment of influenza in Japan and China.
T746 4574-4668 Sentence denotes It is a pyrazinamide derivative that has shown some activity against a variety of RNA viruses.
T747 4669-4736 Sentence denotes 226 Favipiravir inhibits viral RdRP via its similarity to guanine.
T748 4737-4970 Sentence denotes After biotransformation into its active metabolite, favipiravir‐ribofuranosyl‐5'‐triphosphate, it is incorporated into newly synthesized RNA by RdRP, leading to premature chain termination 227 similar to remdesivir's mode of action.
T749 4971-5066 Sentence denotes Favipiravir is currently being studied around the world as a treatment option against COVID‐19.
T750 5067-5096 Sentence denotes Very recently, Sheahan et al.
T751 5097-5184 Sentence denotes 228 reported the discovery of EIDD‐1931 and its orally bioavailable prodrug EIDD‐2801.
T752 5185-5384 Sentence denotes These nucleoside analogs have shown remarkable potency against SARS‐CoV‐2 and other related CoVs in vitro and in vivo, with IC50 values in the low nanomolar range, outperforming remdesivir 3–10‐fold.
T753 5385-5525 Sentence denotes The reason for this increased potency could be additional interactions with viral RdRP involving the N4‐hydroxyl group of the cytidine ring.
T754 5526-5617 Sentence denotes 219 The efficacy of EIDD‐2801 in COVID‐19 patients is being evaluated in a clinical trial.
T755 5618-5621 Sentence denotes 229
T756 5622-5857 Sentence denotes Remdesivir and other potential RdRP inhibitors 230 are currently being studied in clinical trials around the world, but even though preliminary results appear promising, it is too early to assess their clinical value against COVID‐19.