PMC:7461420 / 8016-8649 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7461420","sourcedb":"PMC","sourceid":"7461420","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7461420","text":"Upon fusion, the contents of the virus particle are released into the host cell's cytoplasm. The virus's genomic positive‐sense RNA, which comprises two overlapping open reading frames (ORFs), ORF1a and ORF1b, is quickly translated into two polyproteins, pp1a and pp1ab. These proteins are the so‐called replicase‐transcriptase‐complex, because of their role in replication and further transcription. The newly formed polyproteins are immediately autocatalytically proteolyzed into smaller proteins by two viral proteases, 3C‐like protease (3CLpro), otherwise known as main protease (Mpro), and papain‐like protease (PLpro). 21 , 22","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T37","span":{"begin":75,"end":81},"obj":"Body_part"},{"id":"T38","span":{"begin":82,"end":91},"obj":"Body_part"},{"id":"T39","span":{"begin":128,"end":131},"obj":"Body_part"},{"id":"T40","span":{"begin":277,"end":285},"obj":"Body_part"},{"id":"T41","span":{"begin":490,"end":498},"obj":"Body_part"}],"attributes":[{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T90","span":{"begin":33,"end":38},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T91","span":{"begin":75,"end":81},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T92","span":{"begin":97,"end":104},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T93","span":{"begin":631,"end":633},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"}],"attributes":[{"subj":"T90","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T37","span":{"begin":277,"end":285},"obj":"Chemical"},{"id":"T38","span":{"begin":490,"end":498},"obj":"Chemical"}],"attributes":[{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":314,"end":327},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T8","span":{"begin":314,"end":327},"obj":"http://purl.obolibrary.org/obo/GO_0003899"},{"id":"T9","span":{"begin":386,"end":399},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"attributes":[{"subj":"T7","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"312","span":{"begin":255,"end":259},"obj":"Gene"},{"id":"313","span":{"begin":584,"end":588},"obj":"Gene"}],"attributes":[{"id":"A312","pred":"tao:has_database_id","subj":"312","obj":"Gene:5499"},{"id":"A313","pred":"tao:has_database_id","subj":"313","obj":"Gene:8673700"},{"subj":"312","pred":"source","obj":"LitCovid-PubTator"},{"subj":"313","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T98","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T99","span":{"begin":93,"end":270},"obj":"Sentence"},{"id":"T100","span":{"begin":271,"end":400},"obj":"Sentence"},{"id":"T101","span":{"begin":401,"end":624},"obj":"Sentence"},{"id":"T102","span":{"begin":625,"end":633},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T98","pred":"source","obj":"LitCovid-sentences"},{"subj":"T99","pred":"source","obj":"LitCovid-sentences"},{"subj":"T100","pred":"source","obj":"LitCovid-sentences"},{"subj":"T101","pred":"source","obj":"LitCovid-sentences"},{"subj":"T102","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#be93ec","default":true},{"id":"LitCovid-PD-CLO","color":"#93eca4"},{"id":"LitCovid-PD-CHEBI","color":"#ec939b"},{"id":"LitCovid-PD-GO-BP","color":"#93b6ec"},{"id":"LitCovid-PubTator","color":"#d0ec93"},{"id":"LitCovid-sentences","color":"#ec93ea"}]}]}}