PMC:7461420 / 78209-78870
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T277 | 218-223 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T278 | 643-647 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T369 | 145-149 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T925 | 133-141 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T926 | 186-194 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T927 | 213-217 | http://purl.obolibrary.org/obo/CLO_0009524 | denotes | Vero |
| T928 | 213-217 | http://purl.obolibrary.org/obo/CLO_0050515 | denotes | Vero |
| T929 | 218-223 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T930 | 272-273 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T931 | 403-404 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T932 | 617-625 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T933 | 643-647 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T23665 | 15-20 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T51563 | 176-185 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T1863 | 377-389 | Chemical | denotes | methyl group | http://purl.obolibrary.org/obo/CHEBI_32875 |
| T25019 | 377-383 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_29309 |
| T26688 | 384-389 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T68003 | 483-489 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
| T37926 | 490-500 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2436 | 145-153 | Species | denotes | SARS‐CoV | Tax:694009 |
| 2437 | 313-318 | Chemical | denotes | PLpro |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T675 | 0-63 | Sentence | denotes | Next, the same group studied the SARs for compound 158 further. |
| T676 | 64-224 | Sentence | denotes | This led to the discovery of compound 165 with high PLpro inhibitory activity of SARS‐CoV‐1 (IC50, 0.32 µM) and antiviral activity (EC50, 9.1 µM) in Vero cells. |
| T677 | 225-319 | Sentence | denotes | 199 The mode of action of 165 was found to be a noncovalent, competitive inhibition of PLpro. |
| T678 | 320-451 | Sentence | denotes | Unlike the previous series, the stereochemistry at the α‐methyl group did not make a significant difference in inhibition of PLpro. |
| T679 | 452-661 | Sentence | denotes | For example, both (S)‐ and (R)‐methyl inhibitors, 165 (IC50, 0.32 µM; EC50, 9.1 µM and 166 (IC50, 0.56 µM; EC50, 9.1 µM), respectively, shared equipotent inhibitory activity in enzymatic and cell‐based assays. |