PMC:7461420 / 71204-71638 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T856","span":{"begin":12,"end":20},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T857","span":{"begin":82,"end":90},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T858","span":{"begin":195,"end":197},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T859","span":{"begin":254,"end":256},"obj":"http://purl.obolibrary.org/obo/CLO_0008307"},{"id":"T860","span":{"begin":257,"end":259},"obj":"http://purl.obolibrary.org/obo/CLO_0008285"},{"id":"T861","span":{"begin":299,"end":300},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T862","span":{"begin":332,"end":333},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T863","span":{"begin":384,"end":387},"obj":"http://purl.obolibrary.org/obo/CLO_0054061"}],"text":"SAR studies focusing on the benzotriazole moiety of 129 were performed to improve activity. The replacement of this group with 4‐phenyl‐1,2,3‐triazole (as in 130) was somewhat tolerated (IC50 of 11 µM; Figure 32). Further modifications to the acetamide (P2‐P1' region) resulted in molecules bearing a thiophene ring on one side and a branched i‐propyl amide (131) or cyclobutylamide (132) on the other—reaching IC50 values below 5 µM."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T362","span":{"begin":28,"end":41},"obj":"Chemical"},{"id":"T82901","span":{"begin":116,"end":121},"obj":"Chemical"},{"id":"T364","span":{"begin":129,"end":135},"obj":"Chemical"},{"id":"T44892","span":{"begin":142,"end":150},"obj":"Chemical"},{"id":"T366","span":{"begin":243,"end":252},"obj":"Chemical"},{"id":"T73169","span":{"begin":254,"end":256},"obj":"Chemical"},{"id":"T368","span":{"begin":257,"end":259},"obj":"Chemical"},{"id":"T369","span":{"begin":281,"end":290},"obj":"Chemical"},{"id":"T40652","span":{"begin":301,"end":310},"obj":"Chemical"},{"id":"T33623","span":{"begin":345,"end":351},"obj":"Chemical"},{"id":"T20512","span":{"begin":352,"end":357},"obj":"Chemical"}],"attributes":[{"id":"A60694","pred":"chebi_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/CHEBI_75331"},{"id":"A10126","pred":"chebi_id","subj":"T82901","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A75743","pred":"chebi_id","subj":"T364","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A97064","pred":"chebi_id","subj":"T44892","obj":"http://purl.obolibrary.org/obo/CHEBI_38597"},{"id":"A59282","pred":"chebi_id","subj":"T366","obj":"http://purl.obolibrary.org/obo/CHEBI_27856"},{"id":"A97698","pred":"chebi_id","subj":"T73169","obj":"http://purl.obolibrary.org/obo/CHEBI_33472"},{"id":"A6849","pred":"chebi_id","subj":"T368","obj":"http://purl.obolibrary.org/obo/CHEBI_60949"},{"id":"A80654","pred":"chebi_id","subj":"T369","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A80396","pred":"chebi_id","subj":"T40652","obj":"http://purl.obolibrary.org/obo/CHEBI_30856"},{"id":"A32650","pred":"chebi_id","subj":"T33623","obj":"http://purl.obolibrary.org/obo/CHEBI_26308"},{"id":"A88116","pred":"chebi_id","subj":"T20512","obj":"http://purl.obolibrary.org/obo/CHEBI_29337"},{"id":"A4596","pred":"chebi_id","subj":"T20512","obj":"http://purl.obolibrary.org/obo/CHEBI_32988"}],"text":"SAR studies focusing on the benzotriazole moiety of 129 were performed to improve activity. The replacement of this group with 4‐phenyl‐1,2,3‐triazole (as in 130) was somewhat tolerated (IC50 of 11 µM; Figure 32). Further modifications to the acetamide (P2‐P1' region) resulted in molecules bearing a thiophene ring on one side and a branched i‐propyl amide (131) or cyclobutylamide (132) on the other—reaching IC50 values below 5 µM."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2243","span":{"begin":0,"end":3},"obj":"Species"},{"id":"2244","span":{"begin":28,"end":41},"obj":"Chemical"},{"id":"2245","span":{"begin":127,"end":150},"obj":"Chemical"},{"id":"2246","span":{"begin":243,"end":252},"obj":"Chemical"},{"id":"2247","span":{"begin":301,"end":310},"obj":"Chemical"},{"id":"2248","span":{"begin":343,"end":357},"obj":"Chemical"},{"id":"2249","span":{"begin":367,"end":382},"obj":"Chemical"}],"attributes":[{"id":"A2243","pred":"tao:has_database_id","subj":"2243","obj":"Tax:2698737"},{"id":"A2244","pred":"tao:has_database_id","subj":"2244","obj":"MESH:C012771"},{"id":"A2246","pred":"tao:has_database_id","subj":"2246","obj":"MESH:C030686"},{"id":"A2247","pred":"tao:has_database_id","subj":"2247","obj":"MESH:D013876"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"SAR studies focusing on the benzotriazole moiety of 129 were performed to improve activity. The replacement of this group with 4‐phenyl‐1,2,3‐triazole (as in 130) was somewhat tolerated (IC50 of 11 µM; Figure 32). Further modifications to the acetamide (P2‐P1' region) resulted in molecules bearing a thiophene ring on one side and a branched i‐propyl amide (131) or cyclobutylamide (132) on the other—reaching IC50 values below 5 µM."}

{"project":"LitCovid-sentences","denotations":[{"id":"T615","span":{"begin":92,"end":213},"obj":"Sentence"},{"id":"T616","span":{"begin":214,"end":434},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"SAR studies focusing on the benzotriazole moiety of 129 were performed to improve activity. The replacement of this group with 4‐phenyl‐1,2,3‐triazole (as in 130) was somewhat tolerated (IC50 of 11 µM; Figure 32). Further modifications to the acetamide (P2‐P1' region) resulted in molecules bearing a thiophene ring on one side and a branched i‐propyl amide (131) or cyclobutylamide (132) on the other—reaching IC50 values below 5 µM."}