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PMC:7461420 / 69571-70195 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T269 618-623 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T330 47-51 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T331 266-270 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T332 427-431 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T333 590-594 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T844 250-252 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T845 446-447 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T846 486-487 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T847 550-558 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T848 610-623 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T38592 158-172 Chemical denotes peptidomimetic http://purl.obolibrary.org/obo/CHEBI_63175
T67139 173-183 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T80936 247-249 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T81382 540-549 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2179 438-442 Gene denotes Mpro Gene:8673700
2180 328-332 Gene denotes Mpro Gene:8673700
2181 277-281 Gene denotes Mpro Gene:8673700
2182 58-62 Gene denotes Mpro Gene:8673700
2183 47-55 Species denotes SARS‐CoV Tax:694009
2184 266-274 Species denotes SARS‐CoV Tax:694009
2185 427-435 Species denotes SARS‐CoV Tax:694009
2186 296-303 Chemical denotes (R)‐123
2187 409-416 Chemical denotes (R)‐123
2188 520-527 Chemical denotes (R)‐123
2189 577-585 Disease denotes infected MESH:D007239
2190 590-614 Disease denotes SARS‐CoV‐1 infected Vero MESH:C000657245
2191 615-617 CellLine denotes E6 CVCL:4582

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T605 197-282 Sentence denotes The compound with an R‐configuration occupied the S3‐S1' subsites of SARS‐CoV‐1 Mpro.
T606 283-624 Sentence denotes Indeed, only (R)‐123 was able to inhibit the Mpro enzyme with an IC50 value of 1.5 µM, while the (S)‐enantiomer was inactive. (R)‐123 inhibited SARS‐CoV‐1 Mpro in a competitive manner (K i, 1.6 µM) with a noncovalent mode of inhibition. (R)‐123 also showed antiviral activity (12.9 µM) in mock infected and SARS‐CoV‐1 infected Vero E6 cells.