PMC:7461420 / 68614-69134 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T268","span":{"begin":382,"end":392},"obj":"Body_part"}],"attributes":[{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma82773"}],"text":"Kumar et al. described furan‐inserted pyrazolone derivatives as dual SARS‐CoV‐1 Mpro and MERS‐CoV Mpro inhibitors (115–118; Figure 29). 182 Compounds 115, 117, and 118 exhibited the best dual inhibitory activities. Compounds 115 and 116 also displayed inhibitory activity against H5N1 neuraminidase (IC50 2.8, 2.9 µM, respectively). 183 Ramajeyam et al. also disclosed a range of pyrimidine derivatives as SARS‐CoV‐1 Mpro inhibitors (119–121). Compound 121 showed high inhibitory potency with an IC50 value 6.1 µM. 181"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T323","span":{"begin":69,"end":73},"obj":"Disease"},{"id":"T324","span":{"begin":408,"end":412},"obj":"Disease"}],"attributes":[{"id":"A323","pred":"mondo_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A324","pred":"mondo_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Kumar et al. described furan‐inserted pyrazolone derivatives as dual SARS‐CoV‐1 Mpro and MERS‐CoV Mpro inhibitors (115–118; Figure 29). 182 Compounds 115, 117, and 118 exhibited the best dual inhibitory activities. Compounds 115 and 116 also displayed inhibitory activity against H5N1 neuraminidase (IC50 2.8, 2.9 µM, respectively). 183 Ramajeyam et al. also disclosed a range of pyrimidine derivatives as SARS‐CoV‐1 Mpro inhibitors (119–121). Compound 121 showed high inhibitory potency with an IC50 value 6.1 µM. 181"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T830","span":{"begin":204,"end":214},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T831","span":{"begin":234,"end":237},"obj":"http://purl.obolibrary.org/obo/CLO_0001046"},{"id":"T832","span":{"begin":264,"end":272},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T833","span":{"begin":371,"end":372},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T834","span":{"begin":440,"end":443},"obj":"http://purl.obolibrary.org/obo/CLO_0001053"},{"id":"T835","span":{"begin":455,"end":458},"obj":"http://purl.obolibrary.org/obo/CLO_0001053"},{"id":"T836","span":{"begin":517,"end":520},"obj":"http://purl.obolibrary.org/obo/CLO_0054057"}],"text":"Kumar et al. described furan‐inserted pyrazolone derivatives as dual SARS‐CoV‐1 Mpro and MERS‐CoV Mpro inhibitors (115–118; Figure 29). 182 Compounds 115, 117, and 118 exhibited the best dual inhibitory activities. Compounds 115 and 116 also displayed inhibitory activity against H5N1 neuraminidase (IC50 2.8, 2.9 µM, respectively). 183 Ramajeyam et al. also disclosed a range of pyrimidine derivatives as SARS‐CoV‐1 Mpro inhibitors (119–121). Compound 121 showed high inhibitory potency with an IC50 value 6.1 µM. 181"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T46132","span":{"begin":23,"end":28},"obj":"Chemical"},{"id":"T10057","span":{"begin":38,"end":48},"obj":"Chemical"},{"id":"T72340","span":{"begin":98,"end":113},"obj":"Chemical"},{"id":"T95181","span":{"begin":103,"end":113},"obj":"Chemical"},{"id":"T23116","span":{"begin":382,"end":392},"obj":"Chemical"},{"id":"T19786","span":{"begin":419,"end":434},"obj":"Chemical"},{"id":"T97108","span":{"begin":424,"end":434},"obj":"Chemical"}],"attributes":[{"id":"A63352","pred":"chebi_id","subj":"T46132","obj":"http://purl.obolibrary.org/obo/CHEBI_35559"},{"id":"A78788","pred":"chebi_id","subj":"T10057","obj":"http://purl.obolibrary.org/obo/CHEBI_83328"},{"id":"A23178","pred":"chebi_id","subj":"T72340","obj":"http://purl.obolibrary.org/obo/CHEBI_147285"},{"id":"A74709","pred":"chebi_id","subj":"T95181","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A54989","pred":"chebi_id","subj":"T23116","obj":"http://purl.obolibrary.org/obo/CHEBI_16898"},{"id":"A24178","pred":"chebi_id","subj":"T19786","obj":"http://purl.obolibrary.org/obo/CHEBI_147285"},{"id":"A98760","pred":"chebi_id","subj":"T97108","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"Kumar et al. described furan‐inserted pyrazolone derivatives as dual SARS‐CoV‐1 Mpro and MERS‐CoV Mpro inhibitors (115–118; Figure 29). 182 Compounds 115, 117, and 118 exhibited the best dual inhibitory activities. Compounds 115 and 116 also displayed inhibitory activity against H5N1 neuraminidase (IC50 2.8, 2.9 µM, respectively). 183 Ramajeyam et al. also disclosed a range of pyrimidine derivatives as SARS‐CoV‐1 Mpro inhibitors (119–121). Compound 121 showed high inhibitory potency with an IC50 value 6.1 µM. 181"}

{"project":"LitCovid-PubTator","denotations":[{"id":"2140","span":{"begin":419,"end":423},"obj":"Gene"},{"id":"2141","span":{"begin":98,"end":102},"obj":"Gene"},{"id":"2142","span":{"begin":80,"end":84},"obj":"Gene"},{"id":"2143","span":{"begin":69,"end":77},"obj":"Species"},{"id":"2144","span":{"begin":89,"end":97},"obj":"Species"},{"id":"2145","span":{"begin":408,"end":416},"obj":"Species"},{"id":"2146","span":{"begin":38,"end":48},"obj":"Chemical"},{"id":"2147","span":{"begin":382,"end":392},"obj":"Chemical"}],"attributes":[{"id":"A2140","pred":"tao:has_database_id","subj":"2140","obj":"Gene:8673700"},{"id":"A2141","pred":"tao:has_database_id","subj":"2141","obj":"Gene:8673700"},{"id":"A2142","pred":"tao:has_database_id","subj":"2142","obj":"Gene:8673700"},{"id":"A2143","pred":"tao:has_database_id","subj":"2143","obj":"Tax:694009"},{"id":"A2144","pred":"tao:has_database_id","subj":"2144","obj":"Tax:1335626"},{"id":"A2145","pred":"tao:has_database_id","subj":"2145","obj":"Tax:694009"},{"id":"A2146","pred":"tao:has_database_id","subj":"2146","obj":"MESH:C038362"},{"id":"A2147","pred":"tao:has_database_id","subj":"2147","obj":"MESH:C030986"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Kumar et al. described furan‐inserted pyrazolone derivatives as dual SARS‐CoV‐1 Mpro and MERS‐CoV Mpro inhibitors (115–118; Figure 29). 182 Compounds 115, 117, and 118 exhibited the best dual inhibitory activities. Compounds 115 and 116 also displayed inhibitory activity against H5N1 neuraminidase (IC50 2.8, 2.9 µM, respectively). 183 Ramajeyam et al. also disclosed a range of pyrimidine derivatives as SARS‐CoV‐1 Mpro inhibitors (119–121). Compound 121 showed high inhibitory potency with an IC50 value 6.1 µM. 181"}

{"project":"LitCovid-sentences","denotations":[{"id":"T595","span":{"begin":136,"end":215},"obj":"Sentence"},{"id":"T596","span":{"begin":216,"end":333},"obj":"Sentence"},{"id":"T597","span":{"begin":334,"end":445},"obj":"Sentence"},{"id":"T598","span":{"begin":446,"end":516},"obj":"Sentence"},{"id":"T599","span":{"begin":517,"end":520},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Kumar et al. described furan‐inserted pyrazolone derivatives as dual SARS‐CoV‐1 Mpro and MERS‐CoV Mpro inhibitors (115–118; Figure 29). 182 Compounds 115, 117, and 118 exhibited the best dual inhibitory activities. Compounds 115 and 116 also displayed inhibitory activity against H5N1 neuraminidase (IC50 2.8, 2.9 µM, respectively). 183 Ramajeyam et al. also disclosed a range of pyrimidine derivatives as SARS‐CoV‐1 Mpro inhibitors (119–121). Compound 121 showed high inhibitory potency with an IC50 value 6.1 µM. 181"}