> top > docs > PMC:7461420 > spans > 66288-67250 > annotations

PMC:7461420 / 66288-67250 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T313 175-179 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T314 230-234 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T315 322-326 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T316 792-796 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T814 215-221 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T815 349-357 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T816 606-612 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T817 943-946 http://purl.obolibrary.org/obo/CLO_0001178 denotes 243
T818 943-946 http://purl.obolibrary.org/obo/CLO_0052433 denotes 243

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T11376 12-18 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T88990 512-518 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T308 580-589 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T76303 640-648 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T73811 663-669 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T84389 699-701 Chemical denotes NH http://purl.obolibrary.org/obo/CHEBI_29339|http://purl.obolibrary.org/obo/CHEBI_73424

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2069 333-337 Gene denotes Mpro Gene:8673700
2070 803-807 Gene denotes Mpro Gene:8673700
2071 241-245 Gene denotes Mpro Gene:8673700
2072 186-190 Gene denotes Mpro Gene:8673700
2073 74-84 Species denotes rhinovirus Tax:12059
2074 148-158 Species denotes rhinovirus Tax:12059
2075 175-183 Species denotes SARS‐CoV Tax:694009
2076 230-238 Species denotes SARS‐CoV Tax:694009
2077 322-330 Species denotes SARS‐CoV Tax:694009
2078 392-395 Species denotes SAR Tax:2698737
2079 792-800 Species denotes SARS‐CoV Tax:694009
2080 12-18 Chemical denotes isatin MESH:D007510
2081 20-35 Chemical denotes 2,3‐dioxoindole
2082 512-518 Chemical denotes isatin MESH:D007510
2083 663-669 Chemical denotes isatin MESH:D007510
2084 705-711 Chemical denotes Gly143
2085 713-719 Chemical denotes Ser144
2086 721-727 Chemical denotes Cys145
2087 733-738 Chemical denotes His41

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T574 0-97 Sentence denotes Previously, isatin (2,3‐dioxoindole) derivatives were observed to inhibit rhinovirus 3C protease.
T575 98-246 Sentence denotes 176 Due to the structural similarity between the rhinovirus 3C protease and SARS‐CoV‐1 Mpro, these derivatives were tested against SARS‐CoV‐1 Mpro.
T576 247-386 Sentence denotes Among them, 106 (IC50, 0.95 µM) and 107 (IC50, 0.98 µM) exhibited the best SARS‐CoV‐1 Mpro inhibitory activity in the low micromolar range.
T577 387-545 Sentence denotes 176 SAR studies suggested that the inhibition efficiency was mainly reliant on hydrophobic and electronic properties of the isatin core substitution pattern.
T578 546-634 Sentence denotes Docking studies revealed that the molecules fit well in the active site of the protease.
T579 635-739 Sentence denotes Both carbonyl groups of the isatin core engaged in H‐bonds with NH of Gly143, Ser144, Cys145, and His41.
T580 740-962 Sentence denotes Compounds 106 and 107 176 were more selective for SARS‐CoV‐1 Mpro than other proteases like papain (106, 103 µM; 107, 87.24 µM), chymotrypsin (106, ~1 mM; 107, 10.4 µM), and trypsin (106, 362 µM; 107, 243 µM; Figure 28).