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PMC:7461420 / 63068-75887 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T264 261-265 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T265 1346-1350 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T266 1786-1791 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T267 5426-5437 Body_part denotes pyrimidines http://purl.org/sig/ont/fma/fma82773
T268 5928-5938 Body_part denotes pyrimidine http://purl.org/sig/ont/fma/fma82773
T269 7121-7126 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T270 11273-11277 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T271 11352-11361 Body_part denotes serotonin http://purl.org/sig/ont/fma/fma67245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T297 145-149 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T298 418-422 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T299 467-471 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T300 477-510 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T301 786-790 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T302 1086-1090 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T303 1526-1530 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T304 1575-1579 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T305 1585-1618 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T306 2139-2143 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T307 2358-2362 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T308 2407-2411 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T309 2417-2450 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T310 2579-2583 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T311 2699-2703 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T312 2828-2832 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T313 3395-3399 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T314 3450-3454 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T315 3542-3546 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T316 4012-4016 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T317 4303-4307 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T318 4697-4700 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T319 4772-4776 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T320 5441-5445 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T321 5490-5494 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T322 5500-5533 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T323 5615-5619 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T324 5954-5958 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T325 6067-6070 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T326 6191-6195 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T327 6398-6402 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T328 6447-6451 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T329 6457-6490 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T330 6550-6554 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T331 6769-6773 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T332 6930-6934 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T333 7093-7097 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T334 7205-7209 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T335 7290-7294 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T336 7300-7333 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T337 7808-7812 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T338 7944-7948 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T339 7993-7997 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T340 8080-8084 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T341 8090-8123 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T342 8769-8773 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T343 9270-9274 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T344 9315-9319 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T345 9325-9358 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T346 9438-9442 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T347 10096-10100 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T348 10192-10196 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T349 10333-10337 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T350 10649-10653 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T351 10706-10710 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T352 10716-10749 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T353 10947-10951 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T354 11047-11050 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T355 11146-11150 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T356 11284-11288 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T357 11476-11480 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T358 11560-11564 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T359 11625-11629 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T360 11714-11717 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549
T361 12437-12441 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T362 12808-12818 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T792 222-230 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T793 249-265 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity in cell
T794 376-378 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T795 401-407 http://purl.obolibrary.org/obo/CLO_0001658 denotes Active
T796 528-529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T797 609-610 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T798 621-627 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T799 774-782 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T800 830-838 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T801 932-934 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T802 1043-1044 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T803 1079-1081 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T804 1240-1248 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T805 1346-1350 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T806 1478-1480 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T807 1786-1791 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T808 1877-1878 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T809 1999-2000 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T810 2112-2115 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T811 2200-2202 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T812 2272-2273 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T813 2780-2786 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T814 3435-3441 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T815 3569-3577 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T816 3826-3832 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T817 4163-4166 http://purl.obolibrary.org/obo/CLO_0001178 denotes 243
T818 4163-4166 http://purl.obolibrary.org/obo/CLO_0052433 denotes 243
T819 4232-4240 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T820 4330-4338 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T821 4418-4424 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T822 4501-4502 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T823 4559-4567 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T824 4852-4855 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T825 4880-4883 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T826 5012-5020 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T827 5131-5133 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T828 5196-5204 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T829 5318-5320 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T830 5750-5760 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T831 5780-5783 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T832 5810-5818 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T833 5917-5918 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T834 5986-5989 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T835 6001-6004 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T836 6063-6066 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T837 6100-6103 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T838 6100-6103 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T839 6100-6103 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T840 6100-6103 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T841 6100-6103 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T842 6100-6103 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T843 6100-6103 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T844 6753-6755 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T845 6949-6950 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T846 6989-6990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T847 7053-7061 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T848 7113-7126 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T849 7245-7247 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T850 7427-7435 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T851 7462-7464 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T852 7559-7567 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T853 7618-7620 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T854 7842-7843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T855 7942-7943 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T856 8148-8156 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T857 8218-8226 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T858 8331-8333 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T859 8390-8392 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T860 8393-8395 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T861 8435-8436 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T862 8468-8469 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T863 8520-8523 http://purl.obolibrary.org/obo/CLO_0054061 denotes 132
T864 8728-8737 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T865 8875-8876 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T866 9032-9033 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T867 9253-9261 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T868 9390-9391 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T869 9533-9539 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T870 9744-9752 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T871 9879-9880 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T872 10080-10081 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T873 10282-10283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T874 10441-10442 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T875 10488-10490 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T876 10632-10634 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T877 10879-10882 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T878 10934-10935 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T879 11157-11165 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T880 11188-11190 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T881 11268-11277 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero cell
T882 11352-11361 http://purl.obolibrary.org/obo/CHEBI_28790 denotes serotonin
T883 11397-11399 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T884 11404-11405 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T885 11459-11467 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T886 11536-11541 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T887 11571-11579 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T888 11650-11652 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T889 11895-11897 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T890 11906-11908 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T891 11909-11911 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T892 12142-12150 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T893 12386-12387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T894 12482-12490 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T895 12543-12545 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T896 12555-12558 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T897 12601-12604 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T898 12605-12606 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T899 12656-12659 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T900 12748-12749 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2987 13-21 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T67003 22-32 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T41984 55-61 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T15863 131-141 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T76768 239-248 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T59369 376-378 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T57087 408-414 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T1438 429-444 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T85249 434-444 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T33732 566-579 Chemical denotes benzotriazole http://purl.obolibrary.org/obo/CHEBI_75331
T245 580-585 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T79350 640-646 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T5859 658-667 Chemical denotes thiophene http://purl.obolibrary.org/obo/CHEBI_30856
T72146 669-674 Chemical denotes furan http://purl.obolibrary.org/obo/CHEBI_35559
T52453 680-686 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T96213 820-829 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T97418 932-934 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T89322 1008-1014 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T24837 1097-1112 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T66246 1102-1112 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T32608 1230-1239 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T94953 1394-1402 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T6907 1503-1509 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T89170 1537-1552 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T17573 1542-1552 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T64398 1647-1653 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T16685 1670-1674 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T97378 1852-1858 Chemical denotes thiols http://purl.obolibrary.org/obo/CHEBI_29256
T11735 1863-1875 Chemical denotes nucleophiles http://purl.obolibrary.org/obo/CHEBI_59740
T77735 1960-1970 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T49664 2001-2006 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T1032 2010-2019 Chemical denotes methylene http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728
T11556 2020-2027 Chemical denotes ketones http://purl.obolibrary.org/obo/CHEBI_17087
T88640 2067-2076 Chemical denotes methylene http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728
T70579 2077-2084 Chemical denotes ketones http://purl.obolibrary.org/obo/CHEBI_17087
T67480 2094-2103 Chemical denotes pyridinyl http://purl.obolibrary.org/obo/CHEBI_51635
T79188 2104-2110 Chemical denotes esters http://purl.obolibrary.org/obo/CHEBI_35701
T68953 2150-2165 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T12741 2155-2165 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T14743 2200-2202 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T94708 2237-2247 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T95032 2327-2331 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T75474 2336-2342 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T285 2369-2384 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T81531 2374-2384 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T5212 2529-2543 Chemical denotes etacrynic acid http://purl.obolibrary.org/obo/CHEBI_4876
T80310 2539-2543 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T60378 2552-2557 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T24346 2566-2571 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T26076 2590-2605 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T62302 2595-2605 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T97944 2644-2655 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T99256 2746-2760 Chemical denotes etacrynic acid http://purl.obolibrary.org/obo/CHEBI_4876
T77207 2756-2760 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T49733 2761-2766 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T50928 2898-2904 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T49983 3012-3020 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T25028 3085-3090 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T9229 3091-3096 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T64536 3117-3131 Chemical denotes carbonyl group http://purl.obolibrary.org/obo/CHEBI_23019
T83383 3126-3131 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T57959 3212-3218 Chemical denotes sulfur http://purl.obolibrary.org/obo/CHEBI_26833
T11376 3232-3238 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T88990 3732-3738 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T308 3800-3809 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T76303 3860-3868 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T73811 3883-3889 Chemical denotes isatin http://purl.obolibrary.org/obo/CHEBI_27539
T84389 3919-3921 Chemical denotes NH http://purl.obolibrary.org/obo/CHEBI_29339|http://purl.obolibrary.org/obo/CHEBI_73424
T93906 4275-4286 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T3495 4477-4488 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T34567 4526-4538 Chemical denotes sulfonamides http://purl.obolibrary.org/obo/CHEBI_35358
T8963 4721-4731 Chemical denotes pyrazolone http://purl.obolibrary.org/obo/CHEBI_83328
T52199 4736-4744 Chemical denotes pyrazole http://purl.obolibrary.org/obo/CHEBI_14973|http://purl.obolibrary.org/obo/CHEBI_17241
T97302 4783-4798 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T83876 4788-4798 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T5399 4910-4920 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T15320 5095-5106 Chemical denotes benzylidene http://purl.obolibrary.org/obo/CHEBI_29857
T78951 5120-5130 Chemical denotes pyrazolone http://purl.obolibrary.org/obo/CHEBI_83328
T73608 5149-5157 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T55153 5291-5297 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T36598 5350-5361 Chemical denotes benzylidene http://purl.obolibrary.org/obo/CHEBI_29857
T28060 5376-5378 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T330 5426-5437 Chemical denotes pyrimidines http://purl.obolibrary.org/obo/CHEBI_39447
T14027 5452-5467 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T68110 5457-5467 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T46132 5569-5574 Chemical denotes furan http://purl.obolibrary.org/obo/CHEBI_35559
T10057 5584-5594 Chemical denotes pyrazolone http://purl.obolibrary.org/obo/CHEBI_83328
T72340 5644-5659 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T95181 5649-5659 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T23116 5928-5938 Chemical denotes pyrimidine http://purl.obolibrary.org/obo/CHEBI_16898
T19786 5965-5980 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T97108 5970-5980 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T42754 6132-6141 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T30698 6318-6328 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T73037 6373-6382 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T42876 6409-6424 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T47808 6414-6424 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T38592 6661-6675 Chemical denotes peptidomimetic http://purl.obolibrary.org/obo/CHEBI_63175
T67139 6676-6686 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T80936 6750-6752 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T81382 7043-7052 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T52596 7226-7228 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T56133 7249-7251 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T56319 7462-7464 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T49271 7503-7512 Chemical denotes imidazole http://purl.obolibrary.org/obo/CHEBI_14434|http://purl.obolibrary.org/obo/CHEBI_16069
T32879 7618-7620 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T49388 7652-7662 Chemical denotes pyridazine http://purl.obolibrary.org/obo/CHEBI_30954
T17367 7673-7681 Chemical denotes pyrazine http://purl.obolibrary.org/obo/CHEBI_30953
T91954 7756-7761 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T60925 7844-7857 Chemical denotes benzotriazole http://purl.obolibrary.org/obo/CHEBI_75331
T359 8004-8019 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T8758 8009-8019 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T361 8035-8048 Chemical denotes benzotriazole http://purl.obolibrary.org/obo/CHEBI_75331
T362 8164-8177 Chemical denotes benzotriazole http://purl.obolibrary.org/obo/CHEBI_75331
T82901 8252-8257 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T364 8265-8271 Chemical denotes phenyl http://purl.obolibrary.org/obo/CHEBI_30396
T44892 8278-8286 Chemical denotes triazole http://purl.obolibrary.org/obo/CHEBI_38597
T366 8379-8388 Chemical denotes acetamide http://purl.obolibrary.org/obo/CHEBI_27856
T73169 8390-8392 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T368 8393-8395 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T369 8417-8426 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T40652 8437-8446 Chemical denotes thiophene http://purl.obolibrary.org/obo/CHEBI_30856
T33623 8481-8487 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T20512 8488-8493 Chemical denotes amide http://purl.obolibrary.org/obo/CHEBI_29337|http://purl.obolibrary.org/obo/CHEBI_32988
T75590 8610-8620 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T56130 8780-8795 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T18706 8785-8795 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T1326 8886-8896 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T64169 8982-8995 Chemical denotes amentoflavone http://purl.obolibrary.org/obo/CHEBI_2631
T59925 9056-9065 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T37429 9203-9210 Chemical denotes Flavone http://purl.obolibrary.org/obo/CHEBI_42491
T50088 9215-9224 Chemical denotes terpenoid http://purl.obolibrary.org/obo/CHEBI_26873
T70109 9402-9412 Chemical denotes terpenoids http://purl.obolibrary.org/obo/CHEBI_26873
T15757 9489-9499 Chemical denotes ferruginol http://purl.obolibrary.org/obo/CHEBI_78274
T36758 9578-9585 Chemical denotes quinone http://purl.obolibrary.org/obo/CHEBI_36141
T94996 9594-9607 Chemical denotes triterpenoids http://purl.obolibrary.org/obo/CHEBI_36615
T73008 9608-9617 Chemical denotes celastrol http://purl.obolibrary.org/obo/CHEBI_63959
T79894 9670-9678 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T67952 9849-9856 Chemical denotes quinone http://purl.obolibrary.org/obo/CHEBI_36141
T30069 9865-9870 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T88567 9975-9985 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T18606 10035-10043 Chemical denotes abietane http://purl.obolibrary.org/obo/CHEBI_35673
T56627 10049-10061 Chemical denotes diterpenoids http://purl.obolibrary.org/obo/CHEBI_23849
T52241 10131-10145 Chemical denotes betulinic acid http://purl.obolibrary.org/obo/CHEBI_3087
T39477 10141-10145 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T42875 10262-10272 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T79585 10304-10306 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T63566 10351-10361 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T7874 10363-10370 Chemical denotes sulfone http://purl.obolibrary.org/obo/CHEBI_35850
T71562 10660-10675 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T25413 10665-10675 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T35111 10958-10973 Chemical denotes Mpro inhibitors http://purl.obolibrary.org/obo/CHEBI_147285
T69746 10963-10973 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T12655 11022-11024 Chemical denotes VS http://purl.obolibrary.org/obo/CHEBI_75021
T45180 11052-11054 Chemical denotes VS http://purl.obolibrary.org/obo/CHEBI_75021
T92281 11092-11101 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T42633 11126-11135 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T57933 11352-11361 Chemical denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546
T63607 11362-11372 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T67742 11373-11383 Chemical denotes cinanserin http://purl.obolibrary.org/obo/CHEBI_145999
T60928 11416-11425 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T76939 11668-11678 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T70812 11768-11773 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T94747 11774-11784 Chemical denotes disulfiram http://purl.obolibrary.org/obo/CHEBI_4659
T26685 11822-11829 Chemical denotes ebselen http://purl.obolibrary.org/obo/CHEBI_77543
T67085 11906-11908 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T96011 11909-11911 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T78112 11940-11947 Chemical denotes ebselen http://purl.obolibrary.org/obo/CHEBI_77543
T14009 11979-11989 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T420 12217-12224 Chemical denotes ebselen http://purl.obolibrary.org/obo/CHEBI_77543
T40554 12229-12238 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T66228 12278-12287 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T35779 12760-12768 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T66 12175-12196 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T67 12183-12196 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1921 36-40 Gene denotes Mpro Gene:8673700
1925 156-160 Gene denotes Mpro Gene:8673700
1926 145-153 Species denotes SARS‐CoV Tax:694009
1927 41-61 Chemical denotes Benzotriazole esters
1933 429-433 Gene denotes Mpro Gene:8673700
1934 446-450 Gene denotes Mpro Gene:8673700
1935 418-426 Species denotes SARS‐CoV Tax:694009
1936 467-475 Species denotes SARS‐CoV Tax:694009
1937 408-414 Chemical denotes esters MESH:D004952
1945 797-801 Gene denotes Mpro Gene:8673700
1946 786-794 Species denotes SARS‐CoV Tax:694009
1947 566-585 Chemical denotes benzotriazole ester
1948 628-646 Chemical denotes halopyridyl esters
1949 658-667 Chemical denotes thiophene MESH:D013876
1950 669-674 Chemical denotes furan MESH:C039281
1951 680-686 Chemical denotes indole MESH:C030374
1958 1097-1101 Gene denotes Mpro Gene:8673700
1959 1423-1427 Gene denotes Mpro Gene:8673700
1960 1319-1323 Gene denotes Mpro Gene:8673700
1961 1086-1094 Species denotes SARS‐CoV Tax:694009
1962 1310-1318 Species denotes MERS‐CoV Tax:1335626
1963 994-1027 Chemical denotes halopyridinyl indole carboxylates
1970 1537-1541 Gene denotes Mpro Gene:8673700
1971 1554-1558 Gene denotes Mpro Gene:8673700
1972 1482-1485 Species denotes SAR Tax:2698737
1973 1526-1534 Species denotes SARS‐CoV Tax:694009
1974 1575-1583 Species denotes SARS‐CoV Tax:694009
1975 1489-1522 Chemical denotes halopyridinyl indole carboxylates
1985 2150-2154 Gene denotes Mpro Gene:8673700
1986 1776-1785 Species denotes mammalian Tax:9606
1987 2139-2147 Species denotes SARS‐CoV Tax:694009
1988 1631-1653 Chemical denotes 5‐Halopyridinyl esters
1989 1852-1858 Chemical denotes thiols MESH:D013438
1990 2010-2027 Chemical denotes methylene ketones
1991 2042-2084 Chemical denotes mono‐ and di‐fluorinated methylene ketones
1992 2094-2110 Chemical denotes pyridinyl esters
1993 1890-1902 Disease denotes cytotoxicity MESH:D064420
2000 2369-2373 Gene denotes Mpro Gene:8673700
2001 2386-2390 Gene denotes Mpro Gene:8673700
2002 2358-2366 Species denotes SARS‐CoV Tax:694009
2003 2407-2415 Species denotes SARS‐CoV Tax:694009
2004 2317-2331 Chemical denotes Etacrynic acid MESH:D004976
2005 2336-2342 Chemical denotes isatin MESH:D007510
2028 2590-2594 Gene denotes Mpro Gene:8673700
2029 2984-2988 Gene denotes Mpro Gene:8673700
2030 2839-2843 Gene denotes Mpro Gene:8673700
2031 2710-2714 Gene denotes Mpro Gene:8673700
2032 2579-2587 Species denotes SARS‐CoV Tax:694009
2033 2699-2707 Species denotes SARS‐CoV Tax:694009
2034 2828-2836 Species denotes SARS‐CoV Tax:694009
2035 2871-2874 Species denotes SAR Tax:2698737
2036 2529-2543 Chemical denotes etacrynic acid MESH:D004976
2037 2552-2557 Chemical denotes amide MESH:D000577
2038 2566-2571 Chemical denotes ester MESH:D004952
2039 2634-2655 Chemical denotes Etacrynic carboxamide
2040 2746-2766 Chemical denotes etacrynic acid ester
2041 2898-2904 Chemical denotes chloro
2042 3012-3020 Chemical denotes hydrogen MESH:D006859
2043 3032-3038 Chemical denotes Gln189
2044 3040-3046 Chemical denotes Glu166
2045 3048-3054 Chemical denotes Thr190
2046 3060-3066 Chemical denotes Gln192
2047 3147-3153 Chemical denotes Gly143
2048 3205-3211 Chemical denotes Cys145
2049 3212-3218 Chemical denotes sulfur MESH:D013455
2069 3553-3557 Gene denotes Mpro Gene:8673700
2070 4023-4027 Gene denotes Mpro Gene:8673700
2071 3461-3465 Gene denotes Mpro Gene:8673700
2072 3406-3410 Gene denotes Mpro Gene:8673700
2073 3294-3304 Species denotes rhinovirus Tax:12059
2074 3368-3378 Species denotes rhinovirus Tax:12059
2075 3395-3403 Species denotes SARS‐CoV Tax:694009
2076 3450-3458 Species denotes SARS‐CoV Tax:694009
2077 3542-3550 Species denotes SARS‐CoV Tax:694009
2078 3612-3615 Species denotes SAR Tax:2698737
2079 4012-4020 Species denotes SARS‐CoV Tax:694009
2080 3232-3238 Chemical denotes isatin MESH:D007510
2081 3240-3255 Chemical denotes 2,3‐dioxoindole
2082 3732-3738 Chemical denotes isatin MESH:D007510
2083 3883-3889 Chemical denotes isatin MESH:D007510
2084 3925-3931 Chemical denotes Gly143
2085 3933-3939 Chemical denotes Ser144
2086 3941-3947 Chemical denotes Cys145
2087 3953-3958 Chemical denotes His41
2095 4314-4318 Gene denotes Mpro Gene:8673700
2096 4208-4211 Species denotes SAR Tax:2698737
2097 4303-4311 Species denotes SARS‐CoV Tax:694009
2098 4275-4286 Chemical denotes carboxamide
2099 4396-4402 Chemical denotes Cys145
2100 4477-4488 Chemical denotes carboxamide
2101 4526-4538 Chemical denotes sulfonamides MESH:D013449
2111 4783-4787 Gene denotes Mpro Gene:8673700
2112 5313-5317 Gene denotes Mpro Gene:8673700
2113 4772-4780 Species denotes SARS‐CoV Tax:694009
2114 5029-5033 Species denotes CVB3 Tax:12072
2115 4721-4731 Chemical denotes pyrazolone MESH:C038362
2116 4736-4744 Chemical denotes pyrazole MESH:C031280
2117 5095-5106 Chemical denotes benzylidene
2118 5120-5133 Chemical denotes pyrazolone C4
2119 5341-5361 Chemical denotes carboxyl benzylidene
2126 5452-5456 Gene denotes Mpro Gene:8673700
2127 5469-5473 Gene denotes Mpro Gene:8673700
2128 5441-5449 Species denotes SARS‐CoV Tax:694009
2129 5490-5498 Species denotes SARS‐CoV Tax:694009
2130 5412-5421 Chemical denotes Pyrazoles MESH:D011720
2131 5426-5437 Chemical denotes pyrimidines MESH:D011743
2140 5965-5969 Gene denotes Mpro Gene:8673700
2141 5644-5648 Gene denotes Mpro Gene:8673700
2142 5626-5630 Gene denotes Mpro Gene:8673700
2143 5615-5623 Species denotes SARS‐CoV Tax:694009
2144 5635-5643 Species denotes MERS‐CoV Tax:1335626
2145 5954-5962 Species denotes SARS‐CoV Tax:694009
2146 5584-5594 Chemical denotes pyrazolone MESH:C038362
2147 5928-5938 Chemical denotes pyrimidine MESH:C030986
2152 6202-6206 Gene denotes Mpro Gene:8673700
2153 6191-6199 Species denotes SARS‐CoV Tax:694009
2154 6261-6264 Species denotes SAR Tax:2698737
2155 6132-6141 Chemical denotes dipeptide MESH:D004151
2161 6409-6413 Gene denotes Mpro Gene:8673700
2162 6426-6430 Gene denotes Mpro Gene:8673700
2163 6398-6406 Species denotes SARS‐CoV Tax:694009
2164 6447-6455 Species denotes SARS‐CoV Tax:694009
2165 6373-6382 Chemical denotes dipeptide MESH:D004151
2179 6941-6945 Gene denotes Mpro Gene:8673700
2180 6831-6835 Gene denotes Mpro Gene:8673700
2181 6780-6784 Gene denotes Mpro Gene:8673700
2182 6561-6565 Gene denotes Mpro Gene:8673700
2183 6550-6558 Species denotes SARS‐CoV Tax:694009
2184 6769-6777 Species denotes SARS‐CoV Tax:694009
2185 6930-6938 Species denotes SARS‐CoV Tax:694009
2186 6799-6806 Chemical denotes (R)‐123
2187 6912-6919 Chemical denotes (R)‐123
2188 7023-7030 Chemical denotes (R)‐123
2189 7080-7088 Disease denotes infected MESH:D007239
2190 7093-7117 Disease denotes SARS‐CoV‐1 infected Vero MESH:C000657245
2191 7118-7120 CellLine denotes E6 CVCL:4582
2197 7216-7220 Gene denotes Mpro Gene:8673700
2198 7269-7273 Gene denotes Mpro Gene:8673700
2199 7205-7213 Species denotes SARS‐CoV Tax:694009
2200 7290-7298 Species denotes SARS‐CoV Tax:694009
2201 7300-7345 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
2209 7618-7622 Gene denotes P1 3 Gene:440926
2210 7437-7440 Species denotes SAR Tax:2698737
2211 7503-7512 Chemical denotes imidazole MESH:C029899
2212 7523-7536 Chemical denotes 5‐chlorofuran
2213 7571-7579 Chemical denotes lead 123
2214 7652-7662 Chemical denotes pyridazine MESH:C062482
2215 7673-7681 Chemical denotes pyrazine MESH:D011719
2221 7819-7823 Gene denotes Mpro Gene:8673700
2222 7955-7959 Gene denotes Mpro Gene:8673700
2223 7808-7816 Species denotes SARS‐CoV Tax:694009
2224 7944-7952 Species denotes SARS‐CoV Tax:694009
2225 7844-7857 Chemical denotes benzotriazole MESH:C012771
2231 8004-8008 Gene denotes Mpro Gene:8673700
2232 8059-8063 Gene denotes Mpro Gene:8673700
2233 7993-8001 Species denotes SARS‐CoV Tax:694009
2234 8080-8088 Species denotes SARS‐CoV Tax:694009
2235 8035-8048 Chemical denotes benzotriazole MESH:C012771
2243 8136-8139 Species denotes SAR Tax:2698737
2244 8164-8177 Chemical denotes benzotriazole MESH:C012771
2245 8263-8286 Chemical denotes 4‐phenyl‐1,2,3‐triazole
2246 8379-8388 Chemical denotes acetamide MESH:C030686
2247 8437-8446 Chemical denotes thiophene MESH:D013876
2248 8479-8493 Chemical denotes i‐propyl amide
2249 8503-8518 Chemical denotes cyclobutylamide
2257 8780-8784 Gene denotes Mpro Gene:8673700
2258 8769-8777 Species denotes SARS‐CoV Tax:694009
2259 8911-8927 Species denotes Torreya nucifera Tax:50189
2260 8971-8980 Chemical denotes biflavone
2261 8982-8995 Chemical denotes amentoflavone MESH:C011164
2262 9144-9150 Chemical denotes Val186
2263 9155-9161 Chemical denotes Gln192
2269 9297-9313 Gene denotes 3C‐like protease
2270 9270-9278 Species denotes SARS‐CoV Tax:694009
2271 9315-9323 Species denotes SARS‐CoV Tax:694009
2272 9203-9210 Chemical denotes Flavone MESH:C043562
2273 9215-9224 Chemical denotes terpenoid MESH:D013729
2287 9447-9451 Gene denotes Mpro Gene:8673700
2288 9691-9711 Species denotes Tripterygium regelii Tax:123485
2289 9792-9795 Species denotes SAR Tax:2698737
2290 9438-9446 Species denotes SARS‐CoV Tax:694009
2291 9402-9412 Chemical denotes terpenoids MESH:D013729
2292 9489-9499 Chemical denotes ferruginol MESH:C431074
2293 9578-9593 Chemical denotes quinone‐methide MESH:C068040
2294 9594-9607 Chemical denotes triterpenoids MESH:D014315
2295 9608-9617 Chemical denotes celastrol MESH:C050414
2296 9625-9637 Chemical denotes pritimererin
2297 9649-9658 Chemical denotes tingenone MESH:C009492
2298 9670-9678 Chemical denotes methanol MESH:D000432
2299 9849-9856 Chemical denotes quinone MESH:C004532
2307 10203-10207 Gene denotes Mpro Gene:8673700
2308 10107-10111 Gene denotes Mpro Gene:8673700
2309 10192-10200 Species denotes SARS‐CoV Tax:694009
2310 10096-10104 Species denotes SARS‐CoV Tax:694009
2311 10049-10061 Chemical denotes diterpenoids MESH:D004224
2312 10131-10145 Chemical denotes betulinic acid MESH:C002070
2313 10156-10163 Chemical denotes savinin MESH:C425325
2318 10345-10350 Gene denotes CLpro
2319 10333-10341 Species denotes SARS‐CoV Tax:694009
2320 10363-10370 Chemical denotes sulfone MESH:D013450
2321 10379-10395 Chemical denotes dihydroimidazole
2326 10660-10664 Gene denotes Mpro Gene:8673700
2327 10685-10689 Gene denotes Mpro Gene:8673700
2328 10649-10657 Species denotes SARS‐CoV Tax:694009
2329 10706-10714 Species denotes SARS‐CoV Tax:694009
2334 10958-10962 Gene denotes Mpro Gene:8673700
2335 10947-10955 Species denotes SARS‐CoV Tax:694009
2336 11284-11292 Species denotes SARS‐CoV Tax:694009
2337 11146-11154 Species denotes SARS‐CoV Tax:694009
2346 11636-11640 Gene denotes Mpro Gene:8673700
2347 11429-11433 Gene denotes Mpro Gene:8673700
2348 11487-11491 Gene denotes Mpro Gene:8673700
2349 11476-11484 Species denotes SARS‐CoV Tax:694009
2350 11625-11635 Species denotes SARS‐CoV‐2 Tax:2697049
2351 11560-11570 Species denotes SARS‐CoV‐2 Tax:2697049
2352 11352-11361 Chemical denotes serotonin MESH:D012701
2353 11373-11383 Chemical denotes cinanserin MESH:D002928
2356 11682-11686 Gene denotes Mpro Gene:8673700
2357 11688-11692 Gene denotes Mpro Gene:8673700
2363 11774-11784 Chemical denotes disulfiram MESH:D004221
2364 11795-11803 Chemical denotes carmofur MESH:C017367
2365 11822-11829 Chemical denotes ebselen MESH:C042986
2366 11837-11845 Chemical denotes shikonin MESH:C016101
2367 11875-11880 Chemical denotes PX‐12 MESH:C412893
2374 11993-11997 Gene denotes Mpro Gene:8673700
2375 12126-12130 Gene denotes Mpro Gene:8673700
2376 12448-12452 Gene denotes Mpro Gene:8673700
2377 12437-12447 Species denotes SARS‐CoV‐2 Tax:2697049
2378 12025-12031 Chemical denotes Cys145
2379 12297-12304 Chemical denotes Ebselen MESH:C042986
2382 12616-12624 Disease denotes toxicity MESH:D064420
2383 12804-12818 Disease denotes CoV infections MESH:D018352

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T547 0-40 Sentence denotes 3.1.7 Small molecule inhibitors of Mpro
T548 41-161 Sentence denotes Benzotriazole esters (88–91; Figure 26) were discovered as novel nonpeptidic irreversible inhibitors of SARS‐CoV‐1 Mpro.
T549 162-279 Sentence denotes 168 Among them, 91 exhibited the best enzymatic inhibitory activity, but no antiviral activity in cell‐based assays.
T550 280-389 Sentence denotes The covalent binding mode of 91 was confirmed by electrospray ionization mass spectrometry (ESI‐MS) analyses.
T551 390-445 Sentence denotes Figure 26 Active esters as SARS‐CoV‐1 Mpro inhibitors.
T552 446-715 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus With a slight structural modification from benzotriazole ester, Zhang et al. reported a series of active halopyridyl esters containing thiophene, furan, and indole moieties (92–95; Figure 26).
T553 716-802 Sentence denotes Among them, 93 displayed the highest enzymatic inhibitory activity at SARS‐CoV‐1 Mpro.
T554 803-874 Sentence denotes 169 However, no antiviral activity for this compound was communicated.
T555 875-944 Sentence denotes The irreversible binding mode of 93 was confirmed by ESI‐MS analysis.
T556 945-955 Sentence denotes 170 , 171
T557 956-968 Sentence denotes Ghosh et al.
T558 969-1144 Sentence denotes 172 studied the SARs of halopyridinyl indole carboxylates and identified a series of analogs (96–101; Figure 27) as SARS‐CoV‐1 Mpro inhibitors in the nanomolar potency range.
T559 1145-1264 Sentence denotes The best derivative (100) had high enzymatic inhibitory potency (IC50, 0.030 µM) and antiviral activity (EC50, 6.9 µM).
T560 1265-1383 Sentence denotes Compound 97 was also observed to inhibit the MERS‐CoV Mpro both in enzymatic and cell‐based (EC50, 12.5 µM) bioassays.
T561 1384-1470 Sentence denotes 173 This molecule covalently modified Mpro, which was confirmed by MALDI‐TOF studies.
T562 1471-1553 Sentence denotes Figure 27 SAR of halopyridinyl indole carboxylates as SARS‐CoV‐1 Mpro inhibitors.
T563 1554-1792 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus 5‐Halopyridinyl esters are troublesome drug candidates because of their potential for rapid hydrolysis by various esterases and other enzymes in mammalian cells.
T564 1793-1903 Sentence denotes They can potentially also react nonspecifically with other thiols and nucleophiles, a recipe for cytotoxicity.
T565 1904-1984 Sentence denotes To bypass this problem by developing stable noncovalent inhibitors, Zhang et al.
T566 1985-2166 Sentence denotes 174 reported a group of methylene ketones and analogous mono‐ and di‐fluorinated methylene ketones based on pyridinyl esters (102 and 103; Figure 28) as SARS‐CoV‐1 Mpro inhibitors.
T567 2167-2305 Sentence denotes Enzymatic investigations and ESI‐MS experiments illustrate that those inhibitors bind to their target in a noncovalent, reversible manner.
T568 2306-2385 Sentence denotes Figure 28 Etacrynic acid and isatin derivatives as SARS‐CoV‐1 Mpro inhibitors.
T569 2386-2628 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus An HPLC‐based screening of electrophilic compounds identified the etacrynic acid‐derived amide 106 and ester 107 as SARS‐CoV‐1 Mpro inhibitors with moderate potency.
T570 2629-2870 Sentence denotes 175 Etacrynic carboxamide (105; K i, 35.3 µM) bound more strongly to SARS‐CoV‐1 Mpro than to papain protease, while etacrynic acid ester 104 was more active at papain protease (K i, 3.2 µM) than at SARS‐CoV‐1 Mpro (K i, 45.8 µM; Figure 28).
T571 2871-2957 Sentence denotes SAR studies suggested that chloro substituents were necessary for protease inhibition.
T572 2958-3097 Sentence denotes Docking studies of 105 to Mpro revealed that it forms hydrogen bonds with Gln189, Glu166, Thr190, and Gln192 with its terminal amino group.
T573 3098-3219 Sentence denotes The Michael system carbonyl group interacts with Gly143, and the reactive double bond remained next to the Cys145 sulfur.
T574 3220-3317 Sentence denotes Previously, isatin (2,3‐dioxoindole) derivatives were observed to inhibit rhinovirus 3C protease.
T575 3318-3466 Sentence denotes 176 Due to the structural similarity between the rhinovirus 3C protease and SARS‐CoV‐1 Mpro, these derivatives were tested against SARS‐CoV‐1 Mpro.
T576 3467-3606 Sentence denotes Among them, 106 (IC50, 0.95 µM) and 107 (IC50, 0.98 µM) exhibited the best SARS‐CoV‐1 Mpro inhibitory activity in the low micromolar range.
T577 3607-3765 Sentence denotes 176 SAR studies suggested that the inhibition efficiency was mainly reliant on hydrophobic and electronic properties of the isatin core substitution pattern.
T578 3766-3854 Sentence denotes Docking studies revealed that the molecules fit well in the active site of the protease.
T579 3855-3959 Sentence denotes Both carbonyl groups of the isatin core engaged in H‐bonds with NH of Gly143, Ser144, Cys145, and His41.
T580 3960-4182 Sentence denotes Compounds 106 and 107 176 were more selective for SARS‐CoV‐1 Mpro than other proteases like papain (106, 103 µM; 107, 87.24 µM), chymotrypsin (106, ~1 mM; 107, 10.4 µM), and trypsin (106, 362 µM; 107, 243 µM; Figure 28).
T581 4183-4253 Sentence denotes Zhou et al. extended the SAR studies for further activity improvement.
T582 4254-4339 Sentence denotes Compound 108 bearing carboxamide showed the best SARS‐CoV‐1 Mpro inhibitory activity.
T583 4340-4430 Sentence denotes However, this derivative did not bind covalently to the Cys145 residue of the active site.
T584 4431-4568 Sentence denotes 177 Further structural investigations at the carboxamide of 108 with a variety of substituted sulfonamides did not improve the activity.
T585 4569-4626 Sentence denotes Compound 109 was the best one of that series (Figure 28).
T586 4627-4630 Sentence denotes 178
T587 4631-4799 Sentence denotes The modification of 110, identified by high‐throughput screening (HTS; Figure 29), led to pyrazolone and pyrazole derivatives 111 and 112 as SARS‐CoV‐1 Mpro inhibitors.
T588 4800-4851 Sentence denotes 179 , 180 Taking these as leads, Ramajeyam et al.
T589 4852-4972 Sentence denotes 181 reported compounds 112–114 to be the best‐performing inhibitors of the series(IC50 5.5, 6.8, 8.4 µM, respectively).
T590 4973-5040 Sentence denotes They also observed moderate inhibitory activity against CVB3 3Cpro.
T591 5041-5205 Sentence denotes Structure‐functionality analyses illustrated that the benzylidene ring next to pyrazolone C4 in addition to electron‐withdrawing groups, favors inhibitory activity.
T592 5206-5400 Sentence denotes Molecular modeling studies of 112 predicted that for its inhibitory function, the N1‐phenyl residue in the Mpro S1 site as well as the carboxyl benzylidene moiety in the S3 pocket are important.
T593 5401-5468 Sentence denotes Figure 29 Pyrazoles and pyrimidines as SARS‐CoV‐1 Mpro inhibitors.
T594 5469-5681 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus Kumar et al. described furan‐inserted pyrazolone derivatives as dual SARS‐CoV‐1 Mpro and MERS‐CoV Mpro inhibitors (115–118; Figure 29).
T595 5682-5761 Sentence denotes 182 Compounds 115, 117, and 118 exhibited the best dual inhibitory activities.
T596 5762-5879 Sentence denotes Compounds 115 and 116 also displayed inhibitory activity against H5N1 neuraminidase (IC50 2.8, 2.9 µM, respectively).
T597 5880-5991 Sentence denotes 183 Ramajeyam et al. also disclosed a range of pyrimidine derivatives as SARS‐CoV‐1 Mpro inhibitors (119–121).
T598 5992-6062 Sentence denotes Compound 121 showed high inhibitory potency with an IC50 value 6.1 µM.
T599 6063-6066 Sentence denotes 181
T600 6067-6248 Sentence denotes HTS of NIH molecular libraries (~293 000 substances) yielded the dipeptide 122 containing 3‐pyridyl as hit compound against SARS‐CoV‐1 Mpro with an IC50 value of 2.2 µM (Figure 30).
T601 6249-6343 Sentence denotes Preliminary SAR studies identified 123 and 124 as the most promising inhibitors of the series.
T602 6344-6354 Sentence denotes 184 , 185
T603 6355-6425 Sentence denotes Figure 30 Simple dipeptide derivatives as SARS‐CoV‐1 Mpro inhibitors.
T604 6426-6699 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus The X‐ray crystal structure of 123 attached to SARS‐CoV‐1 Mpro highlighted the compound's identical orientation in the pocket to that of established covalent peptidomimetic inhibitors (Figure 31).
T605 6700-6785 Sentence denotes The compound with an R‐configuration occupied the S3‐S1' subsites of SARS‐CoV‐1 Mpro.
T606 6786-7127 Sentence denotes Indeed, only (R)‐123 was able to inhibit the Mpro enzyme with an IC50 value of 1.5 µM, while the (S)‐enantiomer was inactive. (R)‐123 inhibited SARS‐CoV‐1 Mpro in a competitive manner (K i, 1.6 µM) with a noncovalent mode of inhibition. (R)‐123 also showed antiviral activity (12.9 µM) in mock infected and SARS‐CoV‐1 infected Vero E6 cells.
T607 7128-7229 Sentence denotes Figure 31 The X‐ray crystal structure of 123 bound to the binding pocket of SARS‐CoV‐1 Mpro (PDB ID:
T608 7230-7236 Sentence denotes 3V3M).
T609 7237-7268 Sentence denotes Pockets S1'–S3 are highlighted.
T610 7269-7592 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus [Color figure can be viewed at wileyonlinelibrary.com] To enhance the inhibitory activity, SAR study efforts around P1' of 123 provided compounds containing imidazole (125) and 5‐chlorofuran (126) with equipotent activity to lead 123 (Figure 30).
T611 7593-7746 Sentence denotes Next, the exploration of P1 3‐pyridyl unit of 123 revealed pyridazine (127) and pyrazine (128) which were only tolerated, albeit without any improvement.
T612 7747-7981 Sentence denotes The same group of researchers discovered potent, noncovalent SARS‐CoV‐1 Mpro blockers based on a benzotriazole scaffold in an MLPCN screening, 186 resulting in hit compound 129 (Figure 32) with a SARS‐CoV‐1 Mpro IC50 value of 6.2 µM.
T613 7982-8058 Sentence denotes Figure 32 SARS‐CoV‐1 Mpro inhibitors containing the benzotriazole scaffold.
T614 8059-8227 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus SAR studies focusing on the benzotriazole moiety of 129 were performed to improve activity.
T615 8228-8349 Sentence denotes The replacement of this group with 4‐phenyl‐1,2,3‐triazole (as in 130) was somewhat tolerated (IC50 of 11 µM; Figure 32).
T616 8350-8570 Sentence denotes Further modifications to the acetamide (P2‐P1' region) resulted in molecules bearing a thiophene ring on one side and a branched i‐propyl amide (131) or cyclobutylamide (132) on the other—reaching IC50 values below 5 µM.
T617 8571-8704 Sentence denotes To cut overall molecular weight of the inhibitors, P3‐truncation was performed, which led to potent derivatives (133–137; Figure 32).
T618 8705-8768 Sentence denotes Compound 137 displayed extremely high inhibition (IC50, 51 nM).
T619 8769-8839 Sentence denotes SARS‐CoV‐1 Mpro inhibitors were also discovered from medicinal plants.
T620 8840-8859 Sentence denotes In 2011, Ryu et al.
T621 8860-8935 Sentence denotes 187 disclosed a range of inhibitors obtained from Torreya nucifera leaves.
T622 8936-9089 Sentence denotes Of all the isolated chemicals, the biflavone, amentoflavone (138; Figure 33), was identified as a potent noncompetitive inhibitor with an IC50 of 8.3 µM.
T623 9090-9191 Sentence denotes Docking studies of 138 identified the interactions of Val186 and Gln192 as major sites at the target.
T624 9192-9288 Sentence denotes Figure 33 Flavone and terpenoid derivatives with inhibitory activity against SARS‐CoV‐1 3CLpro.
T625 9289-9471 Sentence denotes 3CLpro, 3C‐like protease; SARS‐CoV, severe acute respiratory syndrome coronavirus They also isolated a series of terpenoids from T. nucifera as anti‐SARS‐CoV Mpro agents (Figure 33).
T626 9472-9549 Sentence denotes 187 Among them, ferruginol (139; IC50 49.6 µM) was the most active compound.
T627 9550-9791 Sentence denotes Additionally, they isolated quinone‐methide triterpenoids celastrol (140), pritimererin (141), and tingenone (142) from methanol extracts of Tripterygium regelii which exhibited fair inhibition activity (IC50 2.6, 9.9, 5.5 µM, respectively).
T628 9792-9926 Sentence denotes SAR studies indicated that for effective inhibition, the quinone‐methide group in ring A and the more lipophilic ring E were critical.
T629 9927-10009 Sentence denotes All compounds were characterized as competitive inhibitors using kinetic analyses.
T630 10010-10020 Sentence denotes Wen et al.
T631 10021-10119 Sentence denotes 188 reported abietane‐type diterpenoids and lignoids with a powerful anti‐SARS‐CoV‐1 Mpro effect.
T632 10120-10255 Sentence denotes Especially betulinic acid (143) and savinin (144) effectively inhibited SARS‐CoV‐1 Mpro (K i 8.2 µM, 9.1 µM, respectively) (Figure 33).
T633 10256-10303 Sentence denotes These inhibitors acted in a competitive manner.
T634 10304-10492 Sentence denotes Lu et al. discovered two hit SARS‐CoV‐1 3CLpro inhibitors, sulfone 145 and dihydroimidazole 146, by structure‐based virtual screening of a compound library of 58 855 chemicals (Figure 34).
T635 10493-10624 Sentence denotes 189 The central structural elements of the hits, determined in docking experiments, were then used for additional analog searches.
T636 10625-10684 Sentence denotes Figure 34 Structure of SARS‐CoV‐1 Mpro inhibitors 145–149.
T637 10685-10835 Sentence denotes Mpro, main protease; SARS‐CoV, severe acute respiratory syndrome coronavirus Computational similarity screening discovered 21 analogs from these hits.
T638 10836-10933 Sentence denotes Among them, the two best compounds 147 and 148 display IC50 values of 0.3 and 3 µM, respectively.
T639 10934-11051 Sentence denotes A variety of SARS‐CoV‐1 Mpro inhibitors have been identified through virtual screening (VS) as an alternative to HTS.
T640 11052-11166 Sentence denotes VS of 50 240 structurally diverse small molecules allowed to identify 104 molecules with anti‐SARS‐CoV‐1 activity.
T641 11167-11318 Sentence denotes Compound 149 (Figure 34) demonstrated potent enzyme inhibition (IC50, 2.5 μM) and an EC50 of 7 μM in Vero cell‐based SARS‐CoV‐1 plaque reduction assays
T642 11319-11434 Sentence denotes Virtual screening identified the serotonin antagonist cinanserin (150, Figure 35) as a potential inhibitor of Mpro.
T643 11435-11519 Sentence denotes It had previously shown activity against SARS‐CoV‐1 Mpro with an IC50 value of 5 µM.
T644 11520-11642 Sentence denotes 190 Subsequent tests revealed its anti‐SARS‐CoV‐2 activity (EC50, 20.6 µM) and an IC50 value of 125 µM (SARS‐CoV‐2 Mpro).
T645 11643-11687 Sentence denotes Figure 35 Covalent bond inhibitors of Mpro.
T646 11688-11899 Sentence denotes Mpro, main protease Their HTS yielded seven primary hits including the approved drugs disulfiram (151) and carmofur (152), as well as ebselen (153), shikonin (154), tideglusib (155), and PX‐12 (156) (Figure 35).
T647 11900-12054 Sentence denotes Using MS/MS analysis, they deduced that ebselen (153) and 156 are irreversible inhibitors of Mpro by covalently attaching to Cys145 of the catalytic dyad.
T648 12055-12131 Sentence denotes Molecular docking was used to illustrate how 151, 154, and 155 bind to Mpro.
T649 12132-12296 Sentence denotes Antiviral activity assays, using real‐time reverse transcription‐PCR, indicated that ebselen and inhibitor “N3” (40; Figure 12) had the strongest antiviral effects.
T650 12297-12411 Sentence denotes Ebselen displayed an EC50 value of 4.67 µM, and “N3” showed an EC50 value of 16.77 µM in a plaque‐reduction assay.
T651 12412-12477 Sentence denotes Ebselen's IC50 value for SARS‐CoV‐2 Mpro was reported at 0.67 µM.
T652 12478-12546 Sentence denotes The activity data of remaining compounds is summarized in Figure 35.
T653 12547-12625 Sentence denotes Ebselen has been studied for an array of diseases and has a very low toxicity.
T654 12626-12697 Sentence denotes 191 , 192 , 193 Its safety has been demonstrated in clinical trials.
T655 12698-12819 Sentence denotes 191 , 192 , 194 It can therefore be considered a promising molecule for the treatment or prevention of CoV infections.