PMC:7461420 / 57361-57695
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T250 | 275-281 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T251 | 285-293 | Body_part | denotes | cysteine | http://purl.org/sig/ont/fma/fma82751 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T724 | 23-24 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T725 | 72-73 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T726 | 124-125 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T727 | 259-265 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T728 | 330-332 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T33650 | 37-43 | Chemical | denotes | ketone | http://purl.obolibrary.org/obo/CHEBI_17087 |
| T37304 | 151-160 | Chemical | denotes | hemiketal | http://purl.obolibrary.org/obo/CHEBI_59772 |
| T45902 | 207-210 | Chemical | denotes | Ser | http://purl.obolibrary.org/obo/CHEBI_17115|http://purl.obolibrary.org/obo/CHEBI_29999 |
| T36506 | 217-220 | Chemical | denotes | Cys | http://purl.obolibrary.org/obo/CHEBI_15356|http://purl.obolibrary.org/obo/CHEBI_17561|http://purl.obolibrary.org/obo/CHEBI_29950 |
| T42212 | 221-223 | Chemical | denotes | SH | http://purl.obolibrary.org/obo/CHEBI_29312|http://purl.obolibrary.org/obo/CHEBI_73651 |
| T45833 | 275-281 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
| T24832 | 285-293 | Chemical | denotes | cysteine | http://purl.obolibrary.org/obo/CHEBI_15356 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1741 | 37-43 | Chemical | denotes | ketone | MESH:D007659 |
| 1742 | 207-213 | Chemical | denotes | Ser‐OH | |
| 1743 | 217-220 | Chemical | denotes | Cys | MESH:D003545 |
| 1744 | 275-281 | Chemical | denotes | serine | MESH:D012694 |
| 1745 | 164-177 | Disease | denotes | hemithioketal |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T501 | 0-334 | Sentence | denotes | It was envisioned that a fluorinated ketone moiety could be utilized as a warhead for targeting proteases, because it forms a thermodynamically stable hemiketal or hemithioketal after nucleophilic attack by Ser‐OH or Cys‐SH residues, which are present in the active sites of serine or cysteine proteases, respectively (see Figure 22). |